Open Close
General Information
Symbol
Dmel\csw
Species
D. melanogaster
Name
corkscrew
Annotation Symbol
CG3954
Feature Type
FlyBase ID
FBgn0000382
Gene Model Status
Stock Availability
Enzyme Name (EC)
Protein-tyrosine-phosphatase (3.1.3.48)
Gene Snapshot
corkscrew (csw) encodes a non receptor tyrosine phosphatase acting downstream of receptor tyrosine kinases (RTKs) such as Egfr, tor and FGF RTKs. The product of csw contributes to growth regulation, cell survival and developmental patterning. [Date last reviewed: 2018-09-06]
Also Known As
E(sev)1A, EG:BACN25G24 .2, l(1)csw, l(1)2Db, l(1)G0170
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:2,094,234..2,115,701 [+]
Recombination map
1-0.6
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. (P29349)
Catalytic Activity (EC)
Experimental Evidence
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)
Predictions / Assertions
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)
Summaries
Gene Group (FlyBase)
CYTOSOLIC PROTEIN TYROSINE PHOSPHATASES -
Cytosolic Protein Tyrosine Phosphatases are non-receptor tyrosine phosphatases. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).
Pathway (FlyBase)
Torso Signaling Pathway Core Components -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
Sevenless Signaling Pathway Core Components -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Fibroblast Growth Factor Receptor Signaling Pathway Core Components -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Protein Function (UniProtKB)
Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw. Dephosphorylates drpr isoform A which is required for the inhibition by drpr isoform A of glial cell engulfment of axonal debris produced following axonal injury (PubMed:22426252).
(UniProt, P29349)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
csw: corkscrew
Hemizygotes die at the larval-pupal transition; dissected third-instar larvae display small imaginal disks. Larval neuroblast cells show low mitotic index, but chromosome morphology appears normal. Homozygous germ-line clones produce inviable embryos with U-shaped or twisted phenotypes, which are unaffected by paternal genotype or developmental temperature. csw6 is viable and fertile with rough eyes.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\csw or the JBrowse view of Dmel\csw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070378
4560
841
FBtr0070379
7664
945
FBtr0070380
4106
682
FBtr0333260
7119
894
Additional Transcript Data and Comments
Reported size (kB)
7.2, 6.0, 4.7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070362
92.4
841
8.46
FBpp0070363
103.8
945
9.47
FBpp0070364
74.5
682
8.66
FBpp0305458
98.3
894
8.16
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
841 (aa); 92.4 (kD)
Comments
One of a couple of products generated by alternative splicing.
External Data
Subunit Structure (UniProtKB)
Interacts with drpr isoform A.
(UniProt, P29349)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\csw using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (24 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
(assigned by UniProt )
Biological Process (19 terms)
Terms Based on Experimental Evidence (19 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
(assigned by UniProt )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\csw in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 32 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 33 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of csw
Transgenic constructs containing regulatory region of csw
Deletions and Duplications ( 22 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
chromosome & larval neuroblast
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
 
12 of 15
Yes
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
11 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
11 of 13
Yes
Yes
8 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
9 of 12
Yes
Yes
6 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
10 of 15
Yes
Yes
10 of 15
Yes
Yes
8 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (19)
10 of 15
Yes
Yes
3 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
3 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904PU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504A3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0M01 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0M82 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0VZ3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 5 )
 
FlyBase curator comment: The mutation in cswT468M.Scer\UAS.P\T is equivalent to the loss-of-function T468M mutation in the human ortholog Hsap\PTPN11, which is associated with LEOPARD syndrome in humans. Although the mutant protein had no phosphatase activity it resulted in gain-of-function ectopic wing vein phenotype in Drosophila; it is not clear how this relates to phenotypes observed in LEOPARD syndrome.
FlyBase curator comment: The mutation in cswY279C.Scer\UAS.P\T is equivalent to the loss-of-function Y279C mutation in the human ortholog Hsap\PTPN11, which is associated with LEOPARD syndrome in humans. Although the mutant protein had no phosphatase activity it resulted in gain-of-function ectopic wing vein and rough eye phenotypes; it is not clear how these relate to phenotypes observed in LEOPARD syndrome.
FlyBase curator comment: The mutation in cswA72S.Scer\UAS.P\T is associated with Noonan's syndrome in humans but although it results in various gain of function effects in transgenic flies it's not clear how these relate to the Noonan's syndrome phenotype.
FlyBase curator comment: The mutation in cswE76K.Scer\UAS.P\T is associated with Noonan's syndrome in humans but although it results in various gain of function effects in transgenic flies it's not clear how these relate to the Noonan's syndrome phenotype.
FlyBase curator comment: The mutation in cswN308D.Scer\UAS.P\T is associated with Noonan's syndrome in humans but although it results in various gain of function effects in transgenic flies it's not clear how these relate to the Noonan's syndrome phenotype.
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
External Data
Subunit Structure (UniProtKB)
Interacts with drpr isoform A.
(UniProt, P29349 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Torso Signaling Pathway Core Components -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
Sevenless Signaling Pathway Core Components -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Fibroblast Growth Factor Receptor Signaling Pathway Core Components -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-0.6
Cytogenetic map
Sequence location
X:2,094,234..2,115,701 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
2D1-2D2
Limits computationally determined from genome sequence between P{EP}ActnEP1193&P{EP}CG4322EP1631 and P{EP}EP1460&P{EP}CG2924EP1596
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
2D1-2D2
(determined by in situ hybridisation) 2C7--D2 (determined by in situ hybridisation)
2D1-2D1
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
cswEsev1A-eOP maps 1 map unit from the telomere of the X chromosome.
Stocks and Reagents
Stocks (24)
Genomic Clones (8)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (116)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: csw CG3954
    Source for merge of: csw l(1)G0170
    Source for merge of: EG:BACN25G24 .2 CG3954
    Source for merge of: csw anon-WO03040301.207 anon-WO03040301.209 anon-WO03040301.219
    Additional comments
    Source for merge of EG:BACN25G24 .2 CG3954 was sequence comparison ( date:000425 ).
    Source for merge of csw anon-WO03040301.207 anon-WO03040301.209 anon-WO03040301.219 was sequence comparison ( date:051113 ).
    Other Comments
    One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
    Expression of a gain-of-function csw construct (P{UAS-csw.src90}) phenocopies gain-of-function mutations and constructs in positive signaling genes in the Egfr pathway.
    csw has a positive role in embryonic mesoderm development.
    Phosphorylation of residues 801 and 854 of dos is required for the recruitment of csw.
    csw SH2 domain function is essential for csw function, but either SH2 domain can fulfill this requirement. csw protein-tyrosine phosphatase activity is required for full csw function, but a catalytically inactive csw protein is capable of providing partial function. Deletion of either the csw protein-tyrosine phosphatase insert of the entire carboxyl terminus does not abolish csw function. csw and activated sev proteins are associated in vivo in a manner that does not require either csw SH2 domain function or tyrosine phosphorylation of sev protein. In contrast, the interaction between csw and dos proteins is dependent on csw SH2 domain function.
    The csw SH2-containing tyrosine phosphatase is required during signalling by sev, Ras85D and phl. Expression of a membrane targeted form of csw can drive R7 photoreceptor development in the absence of sev function.
    Abnormal eye development caused by ectopic expression of an activated form of Src64B is alleviated by dominant-negative mutations of csw or drk.
    The protein encoded by dos is a csw substrate and may also be a direct or indirect target for the tyrosine kinase activity of sev. Mutations that inactivate dos dominantly enhance the effects of reduced csw activity and suppress the effects of either excessive sev or csw activity. Results indicate that dos is a crucial component of the sev signalling pathway and strongly suggest that dephosphorylation of dos by csw promotes R7 photoreceptor differentiation.
    csw is required for terminal embryonic development, for the development of adult structures and during oogenesis for follicle cell development. csw has a role in embryonic ventral cell fate development, in embryonic CNS development and in embryonic tracheal development.
    csw is essential for photoreceptor cell development.
    Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.
    During late embryogenesis csw is required for tracheal morphogenesis as well as determination of ventral ectodermal fates. Embryos that lack csw develop tracheal precursor cells which fail to migrate into their final positions and markers specific for ventral ectodermal cells are missing. csw is also required during imaginal and adult stages.
    On the basis of map position and failure to complement csw mutations are likely to be alleles of csw.
    Mutants of csw display a very strong, highly penetrant suppression of tor mutant embryos, embryos display 4 to 6 abdominal denticle belts.
    Sequence similarity between human src homology protein-tyrosine-phosphatase 2 (SH-PTP2) and csw and their similar patterns of expression suggest that SH-PTP2 is the human homolog of csw.
    Synonym given as "l(1)2Db" on p129 and "l(1)2Dd" on p311.
    csw and phl act in concert to regulate tll expression. csw functions downstream of tor.
    csw is required for photoreceptor development, acts in the developing R7 cell to attenuate the signalling by the sev gene product and is a suppressor of the Egfr phenotype to restore the eye to a nearly normal appearance.
    Hemizygotes die at the larval-pupal transition; dissected third instar larvae display small imaginal discs. Larval neuroblast cells show low mitotic index, but chromosome morphology appears normal. Homozygous germ-line clones produce inviable embryos with U-shaped or twisted phenotypes, which are unaffected by paternal genotype or developmental temperature.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 160 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (23)
    Reported As
    Symbol Synonym
    anon-WO03040301.207
    anon-WO03040301.209
    anon-WO03040301.219
    csw/SHP-2
    l(1)GA114
    Secondary FlyBase IDs
    • FBgn0004637
    • FBgn0026663
    • FBgn0029599
    • FBgn0066824
    • FBgn0066826
    • FBgn0066827
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (244)