• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\cta

General Information
Symbol	Dmel\cta	Species	D. melanogaster
Name	concertina	Annotation symbol	CG17678
Feature type	protein_coding_gene	FlyBase ID	FBgn0000384
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	CG40010, conc
Genomic Location
Chromosome (arm)	2L	Recombination map	2-54.8
Cytogenetic map		Sequence location	2L:22,874,548..22,885,683 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene concertina is referred to in FlyBase by the symbol Dmel\cta (CG17678, FBgn0000384). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. There is experimental evidence that it is involved in the biological process: regulation of embryonic cell shape; gastrulation involving germ band extension. 25 alleles are reported. The phenotypes of these alleles are annotated with: amnioproctodeal invagination; gonad; nurse cell ring canal; egg chamber; ventral furrow. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: G protein alpha subunit, helical insertion; G-protein alpha subunit, group 12; Guanine nucleotide binding protein (G-protein), alpha subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval midgut, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632931_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cta. Gene sequence location is 2L:22874548..22885683.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cta: concertina (T. Schupbach) Maternal-effect lethal, female sterile: Embryos from homozygous mothers gastrulate abnormally; no posterior midgut formed; the germ band does not advance to the dorsal side of the embryo, but as it expands, it is thrown into a series of folds at the ventral side of the embryo. Anterior midgut appears to develop normally. The phenotype is reminiscent of the zygotic embryonic lethal mutation folded gastrulation (fog). At final differentiation, the embryos from cta mothers have a fairly normal array of thoracic and abdominal segments with morphologically normal denticle belts. Defective head skeleton seen in larvae.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms Rho protein signal transduction brush border membrane extrinsic to internal side of plasma membrane D5 dopamine receptor binding adenylate cyclase-modulating G-protein coupled receptor signaling pathway
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References 40A-40B   h35   (Drosophila Heterochromatin Genome Project, 2004) 40-40   (determined by in situ hybridisation)   (Parks and Wieschaus, 1991)
Experimentally Determined Recombination Data
Location	2-54.8 (Schupbach and Wieschaus, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cta for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cta-RA FBtr0111126  NM_001042956   2156   457 cta-RB FBtr0334157  NM_001273767   2764   457
Additional Transcript Data & Comments
Reported size (kB)	2.8, 2.2 (northern blot) (Parks and Wieschaus, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cta-PA   FBpp0110418   52.8   457   8.69     NP_001036421   EAA46036 cta-PB   FBpp0306274   52.8   457   8.69     NP_001260696   AGB93231
Additional Polypeptide Data & Comments
Reported size (kDa)	457 (aa); 53 (kD) (Parks and Wieschaus, 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G-protein alpha subunit, group 12 (IPR000469) Guanine nucleotide binding protein (G-protein), alpha subunit (IPR001019) G protein alpha subunit, helical insertion (IPR011025) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141966   AA201560   AA202062   AA391178   AA392280   AA392724   AA438685   AA439130   AA439822   AA820920   AA941609   AA942581   AA949502   AA952205   AABU01002768 EAA46036   AF211849 AAF17622   AE014134 AGB93231   AI514580   AW941550   AY089534 AAL90272   AY231854   AY232211   BI162929   BI166168   BI166386   BI167765   BI169303   BI236205   BI236677   BI357044   BI363197   BI363203   BI369387   BI372700   BI372778   BI372779   BI374113   BI483584   BI486529   BI577519   BI577749   BQ103421   CO179000   CO187247   CO188517   CO190679   CO262397   CO264061   CO264234   CO274027   CO281861   CO286766   CO288019   CO291325   CO291926   CO293857   CO297387   CO297726   CO297750   CO300944   CO306179   CO308276   CO312700   CO316503   CO321572   CO322791   CO322930   CO329285   CO329898   CO330335   CO332540   CO332943   CO333182   CO333661   CO333868   CO333873   AE014134 EAA46036   EC056855   EC057755   EC058356   EC059014   EC059719   EC062324   EC062974   EC066231   EC067596   EC067924   EC071198   EC073970   EC078335   EC079399   EC083401   EC083471   EC088673   EC090783   EC195040   EC196164   EC198448   EC200643   EC201062   EC204813   EC211950   EC212596   EC215632   EC217100   EC219327   EC223104   EC227829   EC228251   EC229741   EC234592   EC235471   EC236394   EC236609   EC237976   EC238503   EC249942   EC251161   EC251291   EC251507   M94285
UniProtKB/Swiss-Prot	P25157
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   nurse cell   (Parks and Wieschaus, 1991) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   mesoderm   (Parks and Wieschaus, 1991) embryonic stage 1 -- 3   organism | intense & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) adult stage & oogenesis   oocyte   (Parks and Wieschaus, 1991) RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Boto et al., 2010) third segment of antenna   (Boto et al., 2010) maxillary palpus   (Boto et al., 2010)
Additional Descriptive Data
	RT-PCR analysis shows that cta transcript is expressed in the adult head, third segment of the antenna and maxillary palps. (Boto et al., 2010)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval midgut, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary  (764) Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary  764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    257.225 Larval Midgut    149.1 Larval Hindgut    131.1 Larval Malpighian Tubules    114.2 Larval Fat Body    163.6 Larval Salivary Gland    202.5 Larval Trachea    135.4 Larval Carcass    138.125 Adult Head    76.4 Adult Eye    79.65 Adult Brain    105.6 Adult Thoracic-Abdominal Ganglion    94 Adult Crop    104.1 Adult Midgut    95.4 Adult Hindgut    73 Adult Malpighian Tubules    51.7 Adult Fat Body    110.7 Adult Salivary Gland    122.5 Adult Heart    57.95 Adult VirginFemale Spermatheca    76.3 Adult InseminatedFemale Spermatheca    78.4 Adult Ovary    764 Adult Testis    63.5 Adult Male Accessory Gland    214.3 Adult Carcass    72.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    76.4   NA  Eye    79.65   NA  Brain    105.6   257.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    94   NA  Crop    104.1   149.1  Midgut    95.4   131.1  Hindgut    73   114.2  Malpighian Tubules    51.7   163.6  Fat Body    110.7   202.5  Salivary Gland    122.5   NA  Heart    57.95   135.4  Trachea    NA   NA  VirginFemale Spermatheca    76.3   NA  InseminatedFemale Spermatheca    78.4   NA  Ovary    764   NA  Testis    63.5   NA  Male Accessory Gland    214.3   138.125  Carcass    72.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    54 ovary, mated 4-day female    35 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female  (54) ovary, mated 4-day female  (35) testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    54 ovary, mated 4-day female    35 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    54 ovary, mated 4-day female    35 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    54 ovary, mated 4-day female    35 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female  (54) ovary, mated 4-day female  (35) testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    54 ovary, mated 4-day female    35 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    14 central nervous system, pupae P8    19 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    5 head, mated 1-day female    3 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    8 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    6 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    54 ovary, mated 4-day female    35 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr  26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr  26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    26 embryo 04-06hr    15 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    10 embryo 16-18hr    12 embryo 18-20hr    6 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    8 adult female 05day    18 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167    37 embryonic S1    26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2    30 wing disc ML-DmD8    38 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    59 ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (51) Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167  (37) embryonic S1  26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2  (30) wing disc ML-DmD8  (38) wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2  (28) tumorous blood cells mbn2  (59) ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167    37 embryonic S1    26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2    30 wing disc ML-DmD8    38 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    59 ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167    37 embryonic S1    26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2    30 wing disc ML-DmD8    38 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    59 ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167    37 embryonic S1    26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2    30 wing disc ML-DmD8    38 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    59 ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (51) Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167  (37) embryonic S1  26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2  30 wing disc ML-DmD8  (38) wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2  28 tumorous blood cells mbn2  (59) ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167    37 embryonic S1    26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2    30 wing disc ML-DmD8    38 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    59 ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    51 Schneider line 2 Sg4    17 embryonic 1182-4H    13 embryonic GM2    22 embryonic Kc167    37 embryonic S1    26 embryonic S3    23 leg disc CME L1    10 wing disc CME-W2    30 wing disc ML-DmD8    38 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    14 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    59 ovary fGS/OSS    14 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult  (27) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (27) Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult  27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • LD04530 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000384 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17678-RA;CG40005-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage cta5 lethal | embryonic stage | maternal effect | recessive cta1 cta2 cta3 cta4 cta5 Sterility Allele female sterile cta5 ctaVB25 ctaVB37 ctaVT85 ctaVU51 ctaZ2-3945 ctaZ2-4670 female sterile | maternal effect cta1 female sterile | recessive cta1 cta2 cta3 cta4 cta5 Other Phenotypes Allele cell shape defective ctaR277H.MtnA.T:Hsap\MYC wild-type ctaGerm.Q303R ctaGerm.R277C ctaGerm.R277H Phenotype manifest in Allele amnioproctodeal invagination cta5 ctaGerm.Q303R ctaGerm.R277C ctaGerm.R277H cephalopharyngeal skeleton | maternal effect cta1 cta2 cta3 cta4 cta5 egg chamber cta5 embryo | lateral ctaGerm.Q303R ctaGerm.R277C ctaGerm.R277H embryonic/first instar larval cuticle | anterior cta1 embryonic/first instar larval cuticle | maternal effect cta1 cta2 cta3 cta4 cta5 embryonic/first instar larval cuticle | posterior cta1 embryonic epidermis | ventral cta5 extended germ band embryo | maternal effect cta1 cta2 cta3 cta4 cta5 gonad cta5 nurse cell ring canal cta5 posterior endoderm | maternal effect cta1 cta2 cta3 cta4 cta5 posterior midgut primordium | maternal effect cta1 cta2 cta3 cta4 cta5 ventral furrow cta5 ctaGerm.Q303R ctaGerm.R277C ctaGerm.R277H ventral furrow | maternal effect (with Df(2L)C') cta5
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of cta Class Mutagen Stocks Known lesion cta1 ethyl methanesulfonate 0 -- cta2 ethyl methanesulfonate 0 -- cta3 ethyl methanesulfonate 0 -- cta4 ethyl methanesulfonate 0 -- cta5 loss of function allele ethyl methanesulfonate 0 -- ctaR10 0 -- ctaR277H.Scer\UAS.T:Hsap\MYC 0 Yes ctaunspecified 0 -- ctaVB25 P-element activity 0 Yes ctaVB37 P-element activity 0 Yes ctaVT85 P-element activity 0 Yes ctaVU51 P-element activity 0 Yes ctaZ2-3945 ethyl methanesulfonate 0 -- ctaZ2-4670 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cta Class Mutagen Stocks Known lesion ctaHMS02361 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctaJF01607 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctaGerm.Q303R in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes ctaGerm.R277C in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes ctaGerm.R277H in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes ctaGL01049 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ctaMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ctaR277H.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ctatCH321-03L03 in vitro construct - genomic fragment 0 Yes ctatCH321-04I17 in vitro construct - genomic fragment 0 Yes ctatCH321-05E14 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)C (Schupbach and Wieschaus, 1991) Df(2L)C' (Schupbach and Wieschaus, 1989, Dimitri, 1991, Russell and Kaiser, 1994) Df(2L)D1 (Chaouki and Salz, 2006) Df(2L)lt1 (Dimitri, 1991, Russell and Kaiser, 1994) Df(2L)lt5 (Dimitri, 1991, Russell and Kaiser, 1994) Df(2L)lt8 (Dimitri, 1991, Russell and Kaiser, 1994) Df(2L)lt10 (Weiler and Wakimoto, 1998, Wakimoto and Hearn, 1990) Df(2L)lt28 (Wakimoto and Hearn, 1990) Df(2L)lt45 (Wakimoto, 2008.11.19) Df(2L)lt64 (Wakimoto and Hearn, 1990) Df(2L)lt105 (Wakimoto and Hearn, 1990, Russell and Kaiser, 1994) Df(2L)lt109 (Wakimoto, 2008.11.19) Df(2L)lt120 (Wakimoto and Hearn, 1990) Df(2L)lt121 (Wakimoto, 2008.11.19)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL01049} NA P{TRiP.HMS02361} NA P{TRiP.JF01607} NA characterization construct P{ctaQ303R} NA P{ctaR277C} NA P{ctaR277H} NA PBac{CH321-03L03} NA PBac{CH321-04I17} NA PBac{CH321-05E14} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}ctaVB25 NA P{}ctaVB37 NA P{}ctaVT85 NA P{}ctaVU51 NA
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
gastrulation involving germ band extension inferred from mutant phenotype (Parks and Wieschaus, 1991) regulation of embryonic cell shape inferred from mutant phenotype (Parks and Wieschaus, 1991)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 19 terms )
Molecular Function
CV term Evidence References
D5 dopamine receptor binding inferred from biological aspect of ancestor with PANTHER:PTN000026689 (assigned by RefGenome) (Gaudet et al., 2010) G-protein beta/gamma-subunit complex binding inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) GTPase activity inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with mouse Gna13 (FlyBase, 1992-) GTP binding inferred from electronic annotation with InterPro:IPR000469 (FlyBase Curators et al., 2004-) guanyl nucleotide binding non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) signal transducer activity inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010)
Biological Process
CV term Evidence References
adenylate cyclase-modulating G-protein coupled receptor signaling pathway inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) cell surface receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) gastrulation non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) traceable author statement (Leptin, 1999) G-protein coupled receptor signaling pathway inferred from sequence or structural similarity with mouse Gna13 (FlyBase, 1992-) GTP catabolic process inferred from electronic annotation with InterPro:IPR000469 (FlyBase Curators et al., 2004-) posterior midgut invagination non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) regulation of cell shape non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) regulation of embryonic cell shape non-traceable author statement (Leptin, 1999) Rho protein signal transduction inferred from biological aspect of ancestor with PANTHER:PTN000026689 (assigned by RefGenome) (Gaudet et al., 2010) ventral furrow formation non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Cellular Component
CV term Evidence References
brush border membrane inferred from biological aspect of ancestor with PANTHER:PTN000026689 (assigned by RefGenome) (Gaudet et al., 2010) extrinsic to internal side of plasma membrane inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) heterotrimeric G-protein complex inferred from biological aspect of ancestor with PANTHER:PTN000026392 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with mouse Gna13 (FlyBase, 1992-) non-traceable author statement (Leptin, 1999, Swiss-Prot Project Members, 1992.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cta - CG14854 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) cta - Gαs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cta - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cta allele Gene References cta4 Rho1 (Magie et al., 1999) cta5 Rho1 (Magie et al., 1999) RhoGEF2 (Nikolaidou and Barrett, 2004) ctaR277H.MtnA.T:Hsap\MYC RhoGEF2 (Rogers et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 78256 DroID - A comprehensive database of gene and protein interactions. • FBgn0000384 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355131
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RNBV6 Dipteran inclusive ortholog search EOG6JWVP0 Insect inclusive ortholog search EOG6PG4WJ Arthropod inclusive ortholog search EOG69GHZ5 Metazoa inclusive ortholog search EOG68DCP3
Orthologs in Drosophila Species (EOG6RNBV6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG40005     Drosophila melanogaster fruit fly  Dmel\cta     Drosophila simulans   Dsim\GD17672   Y Drosophila sechellia   Dsec\GM26691   Y Drosophila erecta   Dere\GG21411   Y Drosophila yakuba   Dyak\cta   Y Drosophila ananassae   Dana\GF15917   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28748   Y Drosophila persimilis   Dper\GL21168   Y Drosophila willistoni   Dwil\GK14779   Y Drosophila virilis   Dvir\GJ18016   Y Drosophila mojavensis   Dmoj\GI10235   Y Drosophila grimshawi   Dgri\GH13505   Y
Orthologs in non-Drosophila Dipterans (EOG6JWVP0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008630 Y Anopheles gambiae Malaria mosquito  Agam\AGAP009457 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001150 Y
Orthologs in non-Dipteran Insects (EOG6PG4WJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410906 Y Apis mellifera Western honey bee  Amel\GB54613 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021283 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14658 Y Atta cephalotes Leafcutter ant  Acep\ACEP24051 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14917 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18042 Y Linepithema humile Argentine ant  Lhum\LH20805 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24541 Y Solenopsis invicta Red fire ant  Sinv\SINV15231 Y Solenopsis invicta Red fire ant  Sinv\SINV16177 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006142 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006712 Y Pediculus humanus Human body louse  Phum\PHUM222390 Y
Orthologs in non-Insect Arthropods (EOG69GHZ5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RAG-2 Y Ixodes scapularis Deer tick  Isca\ISCW017207 Y Ixodes scapularis Deer tick  Isca\ISCW000156 Y
Orthologs in non-Arthropod Metazoa (EOG68DCP3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gpa-12 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010946gn Y Danio rerio Zebrafish  Drer\gna13a Y Danio rerio Zebrafish  Drer\gna13b Y Danio rerio Zebrafish  Drer\gna12 Y Xenopus tropicalis Western clawed frog  Xtro\gna13 Y Gallus gallus Domestic chicken  Ggal\GNA13 Y Gallus gallus Domestic chicken  Ggal\GNA12 Y Mus musculus House mouse  Mmus\Gna12 Y Mus musculus House mouse  Mmus\Gna13 Y Rattus norvegicus Norway rat  Rnor\Gna12 Y Rattus norvegicus Norway rat  Rnor\Gna13 Y Homo sapiens Human  Hsap\GNA13 Y Homo sapiens Human  Hsap\GNA12 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\GNA13     Hsap\GNA12
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	31132 y1 v1; P{TRiP.JF01607}attP2 41964 y1 sc* v1; P{TRiP.HMS02361}attP2
Genomic Clones ( 1 )
	BACR07M22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 110 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD04530
Other clones	yak-em_cta
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	10987 12106 29761 51560 54734 56796 57132 61156 63294 63442 70502 70975 74008 83111 99390 124729 147284 153797 161405 163601 167348 172806 191305 194475 214277.12 277180 280305 281358 282127 282249 282269 CK01.1C.A8 CK01.31D.F8 CK01.47A.D8 CK01.51A.G4 CK01.73D.D2 CK01.85B.B8 CK01.101A.B4 CK01.115C.G7 CK01.122D.G3 CK01.124A.E4 CK00059 EK027456 EK040658 EK049108 EK058145 EK063808 EK067540 EK077638 EK085238 EK112927 EK137304 EK138219 EK158942 EK170422 EK170454 EK179738 EK185942 EK188914 EK189232 EK198815 EK205004 EK216849 EK229703 EK250439 EK257336 EK265112 EK292436 EK294125 EK295009 EK303821 EK305214 EK306132 EK307559 EK308217 EK308225 LD03669 LD09265 LD11124 LD11839 LD13012 LD13608 LD14493 LD24861 LD25834 LD26890 LD29293 LD29532 LD41137 RE02209 RE06210 RE06503 RE08222 RE10440 RE32235 RE32769 RE43386 RE47954 RE47962 RE55554 RE59743 RE59942 RE59943 RE61633 RE66501 RE69971 RE71212 RE71480
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000384 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355131
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cta CG40010 (FlyBase, 1996-)
Additional comments	Source for merge of cta CG40010 was sequence comparison (date:030301). (FlyBase, 1996-)
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of cta in the hh signalling pathway. (Lum, 2003) Activation of the fog/cta pathway results in ectopic cell shape changes in the gastrula. (Morize et al., 1998) Uniform fog expression rescues the gastrulation defects of fog null embryos but not cta mutant embryos, arguing that cta acts downstream of fog. (Morize et al., 1998) cta protein is required for cell shape changes induced by ectopic fog expression and thus may operate downstream of fog signalling in wild-type embryos. (Morize et al., 1998) Variegation of lt and cta is manifest at phenotypic and gene expression levels in the adult eye, and the larval salivary glands and Malpighian tubules. The relative severity of the effect correlates with the chromosomal rearrangement. Larval imaginal discs do not display variegation, but show uniform reduction of transcription, which correlates in magnitude with the degree of variegation. (Weiler and Wakimoto, 1998) The cta locus displays reduced variation, the HKA test demonstrates that background selection is not the sole force for reducing variation. Reduction of variation does not extend to the ref(2)P locus. (Wayne and Kreitman, 1995) Sequence analysis suggests that cta encodes an alpha subunit of a G protein. cta has a role in cell-cell communication as a mediator of signals between membrane bound receptors and intracellular effectors during gastrulation. (Parks and Wieschaus, 1991) Mutations in cta block the transition from the first slow stochastic phase of gastrulation to the second rapid phase of constriction in the ventral furrow and the posterior midgut invaginations. (Sweeton et al., 1991) Maternal effect gene required for gastrulation. (Wakimoto and Hearn, 1990) Mutations in cta result in a maternal effect phenotype with defects during the early stages of gastrulation and defects in the anteroposterior axis. (Schupbach and Wieschaus, 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001042956 NM_001273767 RefSeq (Proteins) • NP_001036421 NP_001260696 DDBJ / EMBL / GenBank • AA201560 AAA82939 AABU01002768 AAF17622 AAL90272 AF211849 AGB93231 AW941550 AY089534 EAA46036 M94285 Entrez Gene - A searchable database of RefSeq genes. • 3355131 UniProtKB/Swiss-Prot • P25157
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G-protein alpha subunit, group 12 (IPR000469) Guanine nucleotide binding protein (G-protein), alpha subunit (IPR001019) G protein alpha subunit, helical insertion (IPR011025) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD04530
Linkouts
	BioGRID - A database of protein and genetic interactions • 78256 DroID - A comprehensive database of gene and protein interactions. • FBgn0000384 DRSC - Results from RNAi screens. • FBgn0000384 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000384 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17678-RA;CG40005-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000384 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355131 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355131 modMine - Data generated by the modENCODE project. • FBgn0000384
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG17678 (Boto et al., 2010, Ni et al., 2011.7.19, Brandt, 2006, Ni et al., 2008, Ni et al., 2010.12.1) CG40010 (Giot et al., 2003, Boto et al., 2010, Colicelli, 2004) conc (Schaefer et al., 2001, Hampoelz et al., 2005) Cta (Lum, 2003) cta (Kolsch et al., 2007, Fox and Peifer, 2007, Dimitri et al., 2003, Harris et al., 2008, Koelsch and Leptin, 2008, de Wit et al., 2007, Yasuhara and Wakimoto, 2008, Boto et al., 2010, Wakimoto, 2008.11.19, Kunwar et al., 2008, Ratnaparkhi and Zinn, 2007, Lu et al., 2009, Brandt, 2006, Venken et al., 2009, Levine et al., 2007, Zhang et al., 2011, Brodland et al., 2010, Conte et al., 2012, Mathew et al., 2011) mat(2)cta (Dimitri, 1991) mat(2)fog
Name Synonym	concertina (van Steensel, 1999.12.3, Rossi et al., 2007, Yao and Carlson, 2010, Dimitri et al., 2003, Bakal et al., 2007, Chaouki and Salz, 2006, de Wit et al., 2007, Yasuhara and Wakimoto, 2008, Boto et al., 2010, Kunwar et al., 2008, Dimitri et al., 2003, Lu et al., 2009, Yasuhara et al., 2003, Levine et al., 2007, Huang et al., 2010, Brodland et al., 2010) Concertina (Bakal et al., 2007, Koelsch and Leptin, 2008)
Secondary FlyBase IDs
	FBan0017678 FBgn0058010
References ( 120 )
Generate a list of	All references relating to this gene ( 120 )
List References by type	Research paper  ( 57 ) Supplementary material  ( 8 ) Review  ( 21 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 15 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 3 )
	Conte et al., 2012, PLoS ONE 7(4): e34473 A biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo. [FBrf0218026] Mathew et al., 2011, Mol. Cell. Biol. 31(24): 4978--4993 Role for traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. [FBrf0216703] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...