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Gene Dmel\cv

General Information
Symbol	Dmel\cv	Species	D. melanogaster
Name	crossveinless	Annotation symbol	CG12410
Feature type	protein_coding_gene	FlyBase ID	FBgn0000394
Gene Model Status	Current	Stock availability	139 publicly available
Also Known As	tsg2
Genomic Location
Chromosome (arm)	X	Recombination map	1-13.7
Cytogenetic map	5A13-5A13	Sequence location	X:5,584,035..5,587,117 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crossveinless is referred to in FlyBase by the symbol Dmel\cv (CG12410, FBgn0000394). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: jump response; positive regulation of muscle organ development. 26 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic extracoxal depressor muscle 66; wing vein L4; wing vein L3; posterior crossvein; mesothoracic tergum; eye; crossvein; wing vein; anterior crossvein; thoracic adult muscle precursor cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Twisted gastrulation (Tsg) protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, adult heart, larval/adult fat body, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625532_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cv. Gene sequence location is X:5584035..5587117.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cv: crossveinless cv: crossveinless From Weinstein, A., 1920, Proc. Nat. Acad. Sci. USA 6: 625-39. Crossveins absent or traces only present. Veins L3 and L4 slightly delta at tips. Classifiable in unexpanded wings. Wing effects due to excessive contraction in the pupal period, obliterating the cavity which should normally remain between the epithelia to form the vein (Waddington, 1940, J. Genet. 41: 75-139). RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 5A13-5A13   Limits computationally determined from genome sequence between P{EP}Tre1EP496 and P{EP}cvEP1349&P{EP}CG32758EP1368
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-13.7 (Buzzati-Traverso, 1947)
Left of (cM)	sn P{EP}cvEP1349 P{EP}CG32758EP1368 P{EP}EP1405 P{EP}EP404 P{EP}CG42699EP390 P{EP}Act5CEP1604 P{EP}EP1457EP1457 P{EP}CG5928EP1083 P{EP}EP442 P{EP}EP1402 P{EP}EP912EP912 P{EP}α-Man-IEP556 P{EP}EP1321EP1321 P{EP}EP1461 P{EP}IntS6EP371 (Marcus, 2003) l(1)adl4 l(1)adl8 rex l(1)adl9 l(1)adl13 l(1)adl7 l(1)adl16 l(1)adl1 l(1)adl15 l(1)adl6 l(1)adl10 l(1)adl12 l(1)adl14 l(1)adl11 l(1)adl5 sesE drd (Homyk et al., 1986) l(1)CP7 l(1)CP8 (Perez-Chiesa et al., 1987)
Right of (cM)	y P{EP}ActnEP1193 P{EP}dncEP1395 P{EP}CG44774EP425 P{EP}spoonEP1400 P{EP}Tre1EP496 P{EP}CG2982EP1316 P{EP}Fas2EP1462 P{EP}EP365 (Marcus, 2003) l(1)CP9 (Perez-Chiesa et al., 1987) l(1)adl2 l(1)adl3 (Homyk et al., 1986)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cv for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cv-RA FBtr0070804  NM_080525   1893   257 cv-RB FBtr0340464     1308   257 cv-RC FBtr0340465     1742   257
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cv-PA   FBpp0070770   28.9   257   4.36     NP_536786   AAF46063 cv-PB   FBpp0309406   28.9   257   4.36       cv-PC   FBpp0309407   28.9   257   4.36
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Twisted gastrulation (Tsg) protein (IPR006761)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46063   AB210899 BAD95485   AI294417   AY122270 AAM52782   BI216788   BI239733   BI361844   BI372941   BI577141   BI632110   BI633056   CL527896   CO155242   CO155409   CO280907   CO281644   CO283153   CO306606   CO324231   CO327173   CO327576   CO330054   CO330618   CO330740   CZ474304   CZ475221   EC078916   EC090348   EC199657   EC212051   EC216362   EC233824   EC245314   EC246559   EC248872   EC249994   EC255736   GH945600   GH958286   GH965149
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W494
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, adult heart, larval/adult fat body, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea    575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop    1040.8 Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea  (575.2) Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop  (1040.8) Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea    575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop  1040.8 Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea    575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop    1040.8 Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea    575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop    1040.8 Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea  575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop  (1040.8) Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea    575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop  1040.8 Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    109.575 Larval Midgut    42.4 Larval Hindgut    315.7 Larval Malpighian Tubules    49.4 Larval Fat Body    100.6 Larval Salivary Gland    51.5 Larval Trachea    575.2 Larval Carcass    215.775 Adult Head    315.6 Adult Eye    271.875 Adult Brain    91.8 Adult Thoracic-Abdominal Ganglion    117.3 Adult Crop    1040.8 Adult Midgut    48.5 Adult Hindgut    463.6 Adult Malpighian Tubules    69.3 Adult Fat Body    170.1 Adult Salivary Gland    63.8 Adult Heart    132.725 Adult VirginFemale Spermatheca    102.2 Adult InseminatedFemale Spermatheca    120.2 Adult Ovary    150.9 Adult Testis    33.9 Adult Male Accessory Gland    142 Adult Carcass    233.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    315.6   NA  Eye    271.875   NA  Brain    91.8   109.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    117.3   NA  Crop    1040.8   42.4  Midgut    48.5   315.7  Hindgut    463.6   49.4  Malpighian Tubules    69.3   100.6  Fat Body    170.1   51.5  Salivary Gland    63.8   NA  Heart    132.725   575.2  Trachea    NA   NA  VirginFemale Spermatheca    102.2   NA  InseminatedFemale Spermatheca    120.2   NA  Ovary    150.9   NA  Testis    33.9   NA  Male Accessory Gland    142   215.775  Carcass    233.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female    28 head, virgin 4-day female    20 head, virgin 20-day female    26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male    29 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female  (28) head, virgin 4-day female    20 head, virgin 20-day female  26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male  (29) head, mated 4-day male  (27) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8  (27) carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female    28 head, virgin 4-day female    20 head, virgin 20-day female    26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male    29 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female    28 head, virgin 4-day female    20 head, virgin 20-day female    26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male    29 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female    28 head, virgin 4-day female    20 head, virgin 20-day female    26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male    29 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female  28 head, virgin 4-day female    20 head, virgin 20-day female  26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male  29 head, mated 4-day male  27 head, mated 20-day male  (34) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8  27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female    28 head, virgin 4-day female    20 head, virgin 20-day female    26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male    29 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    8 central nervous system, pupae P8    8 head, virgin 1-day female    28 head, virgin 4-day female    20 head, virgin 20-day female    26 head, mated 1-day female    19 head, mated 4-day female    20 head, mated 20-day female    20 head, mated 1-day male    29 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    27 carcass, larvae L3 wandering    14 carcass, 1-day adult    18 carcass, 4-day adult    18 carcass, 20-day adult    20 ovary, virgin 4-day female    11 ovary, mated 4-day female    8 testis, mated 4-day male    7 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    37 embryo 08-10hr    35 embryo 10-12hr    39 embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr  (29) embryo 06-08hr  (37) embryo 08-10hr  (35) embryo 10-12hr  (39) embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr  (30) pupae 2d postWPP  (28) pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    37 embryo 08-10hr    35 embryo 10-12hr    39 embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    37 embryo 08-10hr    35 embryo 10-12hr    39 embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    37 embryo 08-10hr    35 embryo 10-12hr    39 embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr  29 embryo 06-08hr  (37) embryo 08-10hr  (35) embryo 10-12hr  (39) embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr  30 pupae 2d postWPP  28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    37 embryo 08-10hr    35 embryo 10-12hr    39 embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    12 embryo 04-06hr    29 embryo 06-08hr    37 embryo 08-10hr    35 embryo 10-12hr    39 embryo 12-14hr    23 embryo 14-16hr    18 embryo 16-18hr    16 embryo 18-20hr    18 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    14 larva L2    11 larva L3 12hr old    13 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    12 white prepupae new    13 white prepupae 12hr    24 white prepupae 24hr    30 pupae 2d postWPP    28 pupae 3d postWPP    21 pupae 4d postWPP    16 adult male 01day    16 adult male 05day    13 adult male 30day    12 adult female 01day    16 adult female 05day    13 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    36 embryonic 1182-4H    33 embryonic GM2    26 embryonic Kc167    13 embryonic S1    35 embryonic S3    21 leg disc CME L1    28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (52) Schneider line 2 Sg4  (36) embryonic 1182-4H  (33) embryonic GM2  26 embryonic Kc167    13 embryonic S1  (35) embryonic S3    21 leg disc CME L1  (28) wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3  (31) wing disc ML-DmD21  (29) wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (30) mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2  (32) tumorous blood cells mbn2  (28) ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    36 embryonic 1182-4H    33 embryonic GM2    26 embryonic Kc167    13 embryonic S1    35 embryonic S3    21 leg disc CME L1    28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    36 embryonic 1182-4H    33 embryonic GM2    26 embryonic Kc167    13 embryonic S1    35 embryonic S3    21 leg disc CME L1    28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    36 embryonic 1182-4H    33 embryonic GM2    26 embryonic Kc167    13 embryonic S1    35 embryonic S3    21 leg disc CME L1    28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (52) Schneider line 2 Sg4  (36) embryonic 1182-4H  (33) embryonic GM2  26 embryonic Kc167    13 embryonic S1  (35) embryonic S3    21 leg disc CME L1  28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3  31 wing disc ML-DmD21  29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2  32 tumorous blood cells mbn2  28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    36 embryonic 1182-4H    33 embryonic GM2    26 embryonic Kc167    13 embryonic S1    35 embryonic S3    21 leg disc CME L1    28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    36 embryonic 1182-4H    33 embryonic GM2    26 embryonic Kc167    13 embryonic S1    35 embryonic S3    21 leg disc CME L1    28 wing disc CME-W2    14 wing disc ML-DmD8    24 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    29 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    30 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    28 ovary fGS/OSS    16 ovary OSC    8 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • SD27025 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000394 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12410-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die cv34 cv51 viable cv70 cvEY06384 viable, with Scer\GAL4[-]: cvEP1349 viable, with Scer\GAL4pnr-MD237 cvGD3972 Sterility Allele fertile cvEY06384 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 cvGD3972 jumping defective | partially | recessive cv43 visible cv1 cv43 cv68 visible, with cv43 cvScer\UAS.cVa visible, with cvScer\UAS.cVa cv43 visible, with Scer\GAL4ey.PH cvEP1349 visible | recessive cv1 cv18 cv43 cvM1 Phenotype manifest in Allele anterior crossvein cv1 cv18 cv34 cv43 cv51 cvM1 crossvein cv1 cv43 cv68 cv70 eye, with Scer\GAL4ey.PH cvEP1349 mesothoracic extracoxal depressor muscle 66 cv1 cv43 mesothoracic extracoxal depressor muscle 66 (with cv1) cv43 mesothoracic extracoxal depressor muscle 66 (with cv43) cv1 mesothoracic extracoxal depressor muscle 66 (with Df(1)C149) cv1 mesothoracic tergum, with Scer\GAL4pnr-MD237 cvGD3972 posterior crossvein cv1 cv18 cv34 cv43 cv51 cvM1 posterior crossvein, with cv43 cvScer\UAS.cVa posterior crossvein, with cvScer\UAS.cVa cv43 thoracic adult muscle precursor cell cv43 wing vein cv1 cv70 wing vein, with Scer\GAL4A9 cvScer\UAS.cVa wing vein L3 cv1 wing vein L4 cv1
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of cv Class Mutagen Stocks Known lesion cv1 spontaneous 130 Yes cv18 Delta2-3 1 Yes cv43 loss of function allele Delta2-3 1 Yes cvd05070 P-element activity 1 -- cvd06580 P-element activity 1 -- cvEP1349 P-element activity 1 -- cvEY06384 P-element activity 1 -- cv+ 0 -- cv12 Delta2-3 0 Yes cv34 Delta2-3 0 Yes cv45j natural population 0 -- cv51 Delta2-3 0 Yes cv52 Delta2-3 0 Yes cv60 P-element activity 0 Yes cv68 ethyl methanesulfonate 0 -- cv70 P-element activity 0 Yes cvGG01706 0 -- cvM1 0 -- cvunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cv Class Mutagen Stocks Known lesion cvGD3972 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cvKK108780 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cvMtnA.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cvScer\UAS.cVa in vitro construct - regulatory fusion 0 Yes cvScer\UAS.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cvtsg.PV in vitro construct - regulatory fusion 0 Yes cvtsg.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(1)172 (Patterson, 1932) Df(1)231c (Patterson, 1932) Df(1)235 (Patterson, 1932) Df(1)247a (Patterson, 1932) Df(1)247g (Patterson, 1932) Df(1)262 (Patterson, 1932) Df(1)267 (Patterson, 1932) Df(1)271 (Patterson, 1932) Df(1)303 (Patterson, 1932) Df(1)bi-DL3 (Oliver et al., 1988) Df(1)bi-DL5 (Oliver et al., 1988) Df(1)ct268-37 (Demerec, 1940) Df(1)GA56 (Oliver et al., 1988) Df(1)GA102 (Oliver et al., 1988) Df(1)HC244 (Oliver et al., 1988) Df(1)HF366 (Oliver et al., 1988) Df(1)JC70 (Schalet, 1986, Oliver et al., 1988) Df(1)N73 (Jaramillo et al., 2009, Craymer and Roy, 1980, Oliver et al., 1988) Df(1)ovo6 (Oliver et al., 1988) Df(1)ovo7 (Oliver et al., 1988) Df(1)rb1 (Oliver et al., 1988) Df(1)rb13 (Oliver et al., 1988) Df(1)rb30 (Oliver et al., 1988) Df(1)rb33 (Oliver et al., 1988) Df(1)rb46 (Oliver et al., 1988) Df(1)rb47 (Oliver et al., 1988) Df(1)RC40 (Oliver et al., 1988) Df(1)Sp(rb) (Schalet, 1986) T(1;4)231b (Patterson, 1932)
Disrupted in	Df(1)C149 (Jaramillo et al., 2009, Craymer and Roy, 1980, Oliver et al., 1988) Df(1)Exel6236 (Ryder, 2004.4.26) Df(1)M30 (Schultz, 1929)
Duplicated in	Dp(1;1)105 (Dobzhansky, 1932) Dp(1;3)SFV-70k   Dp(1;Y)BSC91 (Cook et al., 2010) Dp(1;Y)BSC92 (Cook et al., 2010) Dp(1;Y)BSC93 (Cook et al., 2010) Dp(1;Y)BSC94 (Cook et al., 2010) Dp(1;Y)BSC95 (Cook et al., 2010) Dp(1;Y)BSC96 (Cook et al., 2010) Dp(1;Y)BSC97 (Cook et al., 2010) Dp(1;Y)BSC98 (Cook et al., 2010) Dp(1;Y)BSC99 (Cook et al., 2010) Dp(1;Y)dx+1 (Jaramillo et al., 2009, Florence, 1999.7.22) Dp(1;Y)dx+3 (Florence, 1999.7.22) Dp(1;Y)dx+4 (Florence, 1999.7.22) Dp(1;Y)dx+5 (Florence, 1999.7.22) Dp(1;Y)dx+6 (Florence, 1999.7.22) Dp(1;Y)dx+7 (Florence, 1999.7.22)
Not duplicated in	Dp(1;1)100 (Dobzhansky, 1932) Dp(1;1)112 (Dobzhansky, 1932) Dp(1;2)w-ec (Schalet, 1986) Dp(1;3)sn13a1 (Schalet, 1986) Dp(1;f)102 (Dobzhansky, 1932) Dp(1;f)106 (Dobzhansky, 1932) Dp(1;f)107 (Dobzhansky, 1932) Dp(1;f)118 (Dobzhansky, 1932) Dp(1;f)136 (Dobzhansky, 1932) Dp(1;f)137 (Dobzhansky, 1932) Dp(1;f)sc7.2
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3972} NA P{KK108780} NA P{UAS-cv} NA characterization construct P{cv-tsg.PV} NA P{tsg-cv.His} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cvEP1349 NA P{EPgy2}cvEY06384 NA P{Mae-UAS.6.11}cvGG01706 NA P{XP}cvd05070 NA P{XP}cvd06580 NA miscellaneous insertions 412{}cv1 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
jump response inferred from mutant phenotype (Jaramillo et al., 2009) positive regulation of muscle organ development inferred from mutant phenotype (Jaramillo et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cv - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - CG4210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - Cg25C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - RpS27A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - gish anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - mor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cv - snama anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cv allele Gene References cv1 Snr1 (Marenda et al., 2004) cvScer\UAS.cVa gbb (Vilmos et al., 2005) sog (Vilmos et al., 2005) unspecified tsg (Vilmos et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69095 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000394 DroID - A comprehensive database of gene and protein interactions. • FBgn0000394 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44510
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TXCC2 Dipteran inclusive ortholog search EOG63V04C Insect inclusive ortholog search EOG6J6QN8 Arthropod inclusive ortholog search EOG69KD6V Metazoa inclusive ortholog search EOG6PS5KH
Orthologs in Drosophila Species (EOG6TXCC2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cv     Drosophila simulans   Dsim\GD16744 Y   Drosophila sechellia   Dsec\GM12427 Y   Drosophila erecta   Dere\GG18776 Y   Drosophila yakuba   Dyak\GE16419 Y   Drosophila ananassae   Dana\GF21369 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11617 Y   Drosophila persimilis   Dper\GL18239 Y   Drosophila willistoni   Dwil\GK19972 Y   Drosophila virilis   Dvir\GJ16717 Y   Drosophila mojavensis   Dmoj\GI16252 Y   Drosophila grimshawi   Dgri\GH12675 Y
Orthologs in non-Drosophila Dipterans (EOG63V04C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009538   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010213   Anopheles gambiae Malaria mosquito  Agam\AGAP000304   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002575
Orthologs in non-Dipteran Insects (EOG6J6QN8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\cv Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015082 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002309 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036108 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11217 Y Atta cephalotes Leafcutter ant  Acep\ACEP18230 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17936 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14975 Y Linepithema humile Argentine ant  Lhum\LH18505 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13887 Y Solenopsis invicta Red fire ant  Sinv\SINV15819 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005929 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005475 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001945 Y Pediculus humanus Human body louse  Phum\PHUM538020 Y Tribolium castaneum Red flour beetle  Tcas\TC003620 Y
Orthologs in non-Insect Arthropods (EOG69KD6V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI Y Ixodes scapularis Deer tick  Isca\ISCW014862 Y
Orthologs in non-Arthropod Metazoa (EOG6PS5KH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009756gn Y Danio rerio Zebrafish  Drer\ENSDARG00000074831 Y Danio rerio Zebrafish  Drer\twsg1a Y Xenopus tropicalis Western clawed frog  Xtro\twsg2 Y Xenopus tropicalis Western clawed frog  Xtro\twsg1 Y Gallus gallus Domestic chicken  Ggal\TWSG1 Y Mus musculus House mouse  Mmus\Twsg1 Y Rattus norvegicus Norway rat  Rnor\Twsg1 Y Homo sapiens Human  Hsap\TWSG1 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\TWSG1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16744 Drosophila sechellia Dsec\GM12427 Drosophila erecta Dere\GG18776 Drosophila yakuba Dyak\GE16419 Drosophila ananassae Dana\GF21369 Drosophila pseudoobscura pseudoobscura Dpse\GA11617 Drosophila persimilis Dper\GL18239 Drosophila willistoni Dwil\GK19972 Drosophila virilis Dvir\GJ16717 Drosophila mojavensis Dmoj\GI16252 Drosophila grimshawi Dgri\GH12675
Stocks & Reagents
Stocks Listed in FlyBase ( 139 )
Bloomington	4182 y1 cv1 8693 w1118 cv18 8694 w1118 cv43 11237 w1118 P{EP}cvEP1349 4497 cv1 v1 run29/FM6
Harvard	- P{XP}cvd05070 - P{XP}cvd06580
Kyoto	107616 y1 cv1 101197 w1 cv1 sn3
VDRC	v106311 P{KK108780}VIE-260B v9727 w1118; P{GD3972}v9727 v9729 w1118; P{GD3972}v9729
	More stocks available...
Genomic Clones ( 2 )
	BACR27C07 BACR27J18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD27025
Other clones	DPiM_SD27025
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP07783 RE24058 RE36308 RE46225 RE60141 RE70784 SD25709
Other clones	40212 42677 46004 63742 64765 120049 164622 191976 192645 193298 214255.52 EK155426 EK157758 EK162358 EK193029 EK251551 EK294435 EK295740 EK296058 EN05707 EN06010 EP06401 EP07557 RP004037863 RP004228638 RP004495121
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000394 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44510
Antibody Information
Other Information
Discoverer
	Bridges, 12th Dec. 1919.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tsg2 CG12410 (Marsh, 2001.4.10)
Source for database merge of	Source for merge of: cv tsg2 (Marsh, 2001.4.24)
Additional comments	The CG11582 gene may have been derived from the cv gene by retroposition. (Dai et al., 2006)
Other Comments
	cv preferentially binds to a dpp/gbb heterodimer, rather than to each protein on its own. Overall orientation not stated: CG3160- cv+ CG3149- (Shimmi et al., 2005) Mutations in cv remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab. (Diaz-Benjumea and Garcia-Bellido, 1990) ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation. (Diaz-Benjumea et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080525 RefSeq (Proteins) • NP_536786 DDBJ / EMBL / GenBank • AAF46063 AAM52782 AB210899 AY122270 BAD95485 BI633056 CL527896 CZ474304 CZ475221 Entrez Gene - A searchable database of RefSeq genes. • 44510 UniProtKB/TrEMBL • Q9W494
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Twisted gastrulation (Tsg) protein (IPR006761) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD27025
Linkouts
	BioGRID - A database of protein and genetic interactions • 69095 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000394 DroID - A comprehensive database of gene and protein interactions. • FBgn0000394 DRSC - Results from RNAi screens. • FBgn0000394 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000394 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12410-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000394 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44510 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/crossveinless.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44510 modMine - Data generated by the modENCODE project. • FBgn0000394
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG12410 (Shimmi et al., 2005, Tseng and Hariharan, 2002, Dai et al., 2006, Keleman et al., 2009.8.5) cv (Ramos et al., 2006, Serpe et al., 2008, Verdier et al., 2006, Jaramillo et al., 2009, Ma et al., 2008, Fritsch et al., 2010, Bonds et al., 2007, Cook et al., 2010) Cv (Serpe et al., 2008) cv-1 (Garcia Abreu et al., 2002) tsg2 (O'Connor et al., 2006, Shimmi et al., 2005, Shimmi and O'Connor, 2002, Marsh, 2001.4.10, Ross et al., 2001, Serpe et al., 2006, ) Tsg2 (Garcia Abreu et al., 2002)
Name Synonym	crossvein (Verdier et al., 2006) crossveinless (Santos et al., 2005, Jaramillo et al., 2009, Costello et al., 2009) Crossveinless (Bonds et al., 2007) twisted gastrulation 2 (Ross et al., 2001)
Secondary FlyBase IDs
	FBgn0029790
References ( 97 )
Generate a list of	All references relating to this gene ( 97 )
List References by type	Research paper  ( 60 ) Supplementary material  ( 5 ) Review  ( 9 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Book  ( 2 ) Letter  ( 1 ) Curated genome annotation  ( 1 ) Stock list  ( 1 ) Conference report  ( 1 )
Recent research papers ( 2 )
	Bianciardi et al., 2012, Genetics 191(3): 703--723 Ribosomal DNA Organization Before and After Magnification in Drosophila melanogaster. [FBrf0218934] Matsuda and Shimmi, 2012, Dev. Biol. 366(2): 153--162 Directional transport and active retention of Dpp/BMP create wing vein patterns in Drosophila. [FBrf0218354] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...