FlyBase Gene Report: Dmel\cv-2

General Information

Symbol

Dmel\cv-2

Species

D. melanogaster

Name

crossveinless 2

Annotation Symbol

CG15671

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000395

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Summary

crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Red Book
Interactive Fly

Also Known As

cv 2, Cv2

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:21,355,015..21,379,464 [-]

Recombination map

2-95

RefSeq locus

NT_033778 REGION:21355015..21379464

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables BMP binding

inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490

(Serpe et al., 2008)

inferred from physical interaction with FLYBASE:gbb; FB:FBgn0024234

(Serpe et al., 2008)

enables BMP receptor binding

inferred from physical interaction with FLYBASE:tkv; FB:FBgn0003716

(Serpe et al., 2008)

enables heparan sulfate proteoglycan binding

inferred from genetic interaction with FLYBASE:botv; FB:FBgn0027535

(Serpe et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables BMP binding

inferred from biological aspect of ancestor with PANTHER:PTN005316910

(assigned by GO_Central )

(Gaudet et al., 2011)

enables BMP receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN005316910

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Dworkin and Gibson, 2006)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Conley et al., 2000)

involved_in positive regulation of BMP signaling pathway

inferred from mutant phenotype

(Serpe et al., 2008, Conley et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in positive regulation of BMP signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN005316910

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Serpe et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN005316910

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Pathway (FlyBase)

Positive Regulators of BMP Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

Positive Regulators of BMP Signaling Pathway -: Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

cv-2: crossveinless on chromosome 2

Anterior and posterior crossveins absent. RK1.

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cv-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W2H2)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cv-2-RA

FBtr0071610

NM_080070

4329

751

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

cv-2-PA

FBpp0071536

83.7

751

8.48

Q9W2H2

NP_524809

AAF46719

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cv-2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cv-2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

organism | dorsal

(Serpe et al., 2008)

third instar larval stage

wing disc | restricted

(Conley et al., 2000)

anterior-posterior compartment boundary of the wing disc

(Conley et al., 2000)

anterior-posterior compartment boundary of imaginal disc

(Serpe et al., 2008)

pupal stage P6

crossvein

(Conley et al., 2000)

crossvein | vicinity of

(Conley et al., 2000)

wing vein

Comment: at the tips

(Conley et al., 2000)

anterior crossvein

(Serpe et al., 2008)

posterior crossvein

(Wagner et al., 2010, Serpe et al., 2008)

wing vein | distal

(Serpe et al., 2008)

presumptive wing vein

(Wagner et al., 2010)

longitudinal vein

(Wagner et al., 2010)

Additional Descriptive Data

cv-2 expression is first visible broadly around the crossveins and the end of the longitudinal veins at 21-22 hr APF. It becomes stronger and refines to a narrow stripe at 28-29 hr APF.

(Wagner et al., 2010)

cv-2 transcripts are most prominent near the anterior-posterior compartment boundaries in third instar imaginal discs, in the anterior and posterior crossveins in pupal wings and at the distal edges of longitudinal wing veins. Heightened expression is also observed in the dorsal regions of early embryos.

(Serpe et al., 2008)

Weak general expression is seen at all stages. In late third instar larvae, cv-2 transcripts are observed in three regions of the prospective notum. One contains and lies distal to the posterior notopleural bristle (pNP) and lies posterior to the anterior notopleural bristle (aNP). One lies distal to the trichoid sensillum (tri1). Transcripts are emphasized along the AP boundary of the prospective wing blade. In pupal wings at 19 hrs APF, transcripts are seen in broad regions around the crossveins. These resolve into narrower regions by 28 hr APF. Increased expression is also observed at the tips of the longitudinal veins.

(Conley et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Serpe et al., 2008)

Expression Deduced from Reporters

Reporter: P{lacW}cv-2^225-3

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

anterior-posterior compartment boundary of the wing disc

(Conley et al., 2000)

wing disc | ubiquitous

Comment: weak

(Conley et al., 2000)

pupal stage

anterior-posterior compartment boundary of the wing disc

(Conley et al., 2000)

Reporter: P{lacW}cv-2^k03511

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6

crossvein

(Conley et al., 2000)

crossvein | vicinity of

(Conley et al., 2000)

wing vein

Comment: at the ends

(Conley et al., 2000)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cv-2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cv-2

View exonic expression by tissue for Dmel\cv-2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45280/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000395

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000395

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000395

Flygut - An atlas of the Drosophila adult midgut

FBgn0000395

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 23 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cv-2

Transgenic constructs containing regulatory region of cv-2

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel6074

(Ryder, 2004.4.26)

Df(2R)Exel6075

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cv-2^GD1411

lethal, with Scer\GAL4^da.Switch.PT

cv-2^GX6589

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cv-2^GD1411

partially lethal - majority die | cold sensitive

viable

viable, with Scer\GAL4^- :

cv-2^EP1103

viable, with Scer\GAL4^Mef2.PR

cv-2^GD1411

viable, with Scer\GAL4^pnr-MD237

cv-2^GD1411

viable, with Scer\GAL4^tin.CΔ4

cv-2^GD1411

Other Phenotypes

Allele

visible

cv-2¹

visible, with Scer\GAL4^A9

visible, with Scer\GAL4^en-e16E

visible | adult stage

visible | dominant

cv-2^225-3

visible | recessive

cv-2^M1

Phenotype manifest in

Allele

anterior crossvein

anterior crossvein (with Df(2R)Pu-D17)

anterior crossvein | ectopic, with Scer\GAL4^ap-md52

cv-2^EP1103

crossvein

cv-2¹

posterior crossvein

posterior crossvein, with Scer\GAL4^A9

cv-2^UAS.cSa

posterior crossvein, with Scer\GAL4^ap-md52

cv-2^EP1103

posterior crossvein, with Scer\GAL4^en-e16E

wing

wing, with Scer\GAL4^en-e16E

cv-2^UAS.cBa

wing | posterior

cv-2^225-3

wing vein

wing vein, with Scer\GAL4^ap-md52

cv-2^EP1103

wing vein (with Df(2R)Pu-D17)

cv-2¹

wing vein | ectopic, with Scer\GAL4^A9

wing vein | ectopic, with Scer\GAL4^ap-md52

cv-2^EP1103

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BMPER

12 of 15

Yes

Hsap\KCP

4 of 15

Yes

Hsap\FCGBP

3 of 15

Hsap\VWC2

3 of 15

Yes

Hsap\VWC2L

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\ZAN

2 of 15

Hsap\CHRD

1 of 15

Hsap\CHRDL1

1 of 15

Yes

Hsap\CHRDL2

1 of 15

Yes

Hsap\COCH

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\NEFM

1 of 15

Yes

Hsap\SSPO

1 of 15

Hsap\VIT

1 of 15

Yes

Hsap\VWF

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Bmper

12 of 15

Yes

Mmus\Fcgbp

3 of 15

Yes

Mmus\Kcp

3 of 15

Yes

Mmus\Vwc2l

3 of 15

Yes

Mmus\Vwc2

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Mmus\Zan

2 of 15

Mmus\Chrdl1

1 of 15

Yes

Mmus\Chrdl2

1 of 15

Yes

Mmus\Chrd

1 of 15

Mmus\Coch

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Nefm

1 of 15

Yes

Mmus\Vit

1 of 15

Yes

Mmus\Vwf

1 of 15

Rattus norvegicus (Norway rat) (21)

Rnor\Bmper

11 of 13

Yes

Rnor\Kcp

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Chrdl1

1 of 13

Yes

Rnor\Chrdl2

1 of 13

Yes

Rnor\Chrd

1 of 13

Rnor\Coch

1 of 13

Yes

Rnor\Crim1

1 of 13

Rnor\Fras1

1 of 13

Yes

Rnor\LOC100909913

1 of 13

Yes

Rnor\Ndp

1 of 13

Yes

Rnor\Vit

1 of 13

Yes

Rnor\Vwc2

1 of 13

Yes

Rnor\Vwf

1 of 13

Xenopus tropicalis (Western clawed frog) (21)

Xtro\bmper

7 of 12

Yes

Xtro\kcp

3 of 12

Yes

Xtro\fras1

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\vwc2

2 of 12

Yes

Xtro\zan

2 of 12

Xtro\chrdl1

1 of 12

Yes

Xtro\coch

1 of 12

Yes

Xtro\crim1

1 of 12

Xtro\LOC101734551

1 of 12

Yes

Xtro\LOC108647325

1 of 12

Yes

Xtro\LOC108647384

1 of 12

Yes

Xtro\nefm

1 of 12

Yes

Xtro\vit

1 of 12

Yes

Xtro\vwf

1 of 12

Danio rerio (Zebrafish) (31)

Drer\bmper

8 of 15

Yes

Drer\si:dkey-266m15.6

4 of 15

Yes

Drer\si:dkey-283b1.7

3 of 15

Yes

Drer\vwc2

3 of 15

Yes

Drer\vwc2l

3 of 15

Yes

Drer\fras1

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\chrdl2

1 of 15

Yes

Drer\crim1

1 of 15

Drer\LOC100329651

1 of 15

Drer\LOC100536599

1 of 15

Yes

Drer\LOC101882112

1 of 15

Yes

Drer\LOC103911950

1 of 15

Yes

Drer\muc2.1

1 of 15

Drer\ndp

1 of 15

Yes

Drer\otog

1 of 15

Drer\si:ch73-329n5.6

1 of 15

Yes

Drer\si:ch211-182p11.1

1 of 15

Yes

Drer\si:ch1073-291c23.1

1 of 15

Yes

Drer\vwf

1 of 15

Drer\zanl

1 of 15

Drer\zgc:112964

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\T01D3.6

3 of 15

Yes

Cele\B0507.1

1 of 15

Yes

Cele\C12D12.1

1 of 15

Yes

Cele\C16E9.1

1 of 15

Yes

Cele\C18H7.1

1 of 15

Cele\clec-199

1 of 15

Yes

Cele\crm-1

1 of 15

Cele\cutl-23

1 of 15

Cele\dct-17

1 of 15

Yes

Cele\dur-1

1 of 15

Yes

Cele\F19C6.3

1 of 15

Cele\F25E2.2

1 of 15

Yes

Cele\F32D8.3

1 of 15

Cele\F55D12.5

1 of 15

Yes

Cele\H13N06.2

1 of 15

Yes

Cele\irg-5

1 of 15

Yes

Cele\pals-39

1 of 15

Yes

Cele\R11G1.1

1 of 15

Yes

Cele\T09D3.3

1 of 15

Yes

Cele\Y8A9A.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CSS1

1 of 15

Yes

Scer\HPF1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

Hml

2 of 10

Burs

1 of 10

CG13252

1 of 10

CG14692

1 of 10

Cpn

1 of 10

Muc14A

1 of 10

Rcd2

1 of 10

shot

1 of 10

sls

1 of 10

tnc

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BMPER; BMP binding endothelial regulator

12 of 15

608699

DIAPHANOSPONDYLODYSOSTOSIS

KCP; kielin cysteine rich BMP regulator

4 of 15

609344

FCGBP; Fc gamma binding protein

3 of 15

617553

VWC2; von Willebrand factor C domain containing 2

3 of 15

611108

VWC2L; von Willebrand factor C domain containing 2 like

3 of 15

619794

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cv-2 - dally

anti tag coimmunoprecipitation, anti tag western blot

(Serpe et al., 2008)

cv-2 - dpp

anti tag coimmunoprecipitation, anti tag western blot

(Serpe et al., 2008)

cv-2 - gbb

anti tag coimmunoprecipitation, anti tag western blot

(Serpe et al., 2008)

cv-2 - tkv

anti tag coimmunoprecipitation, anti tag western blot

(Serpe et al., 2008)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cv-2

suppressible

ash2

(Amoros et al., 2002)

cv-2

enhanceable

dpp

(Conley et al., 2000)

cv-2

enhanceable

gbb

(Conley et al., 2000)

cv-2

suppressible

ltl

(Szuperák et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dpp

suppressible

cv-2

(Serpe et al., 2008)

gbb

suppressible

cv-2

(Serpe et al., 2008)

Gyc76C

suppressible

cv-2|cv|sog

(Schleede and Blair, 2015)

pbl

suppressible

cv-2

(Gregory et al., 2007)

sog

suppressible

cv-2

(Serpe et al., 2008, Ralston and Blair, 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69559

DroID - A comprehensive database of gene and protein interactions.

FBgn0000395

MIST (genetic) - An integrated Molecular Interaction Database

cv-2

MIST (protein-protein) - An integrated Molecular Interaction Database

cv-2

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of BMP Signaling Pathway -: Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-95

Cytogenetic map

57D12-57E1

Sequence location

2R:21,355,015..21,379,464 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57D12-57E1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

57E-57E

(Conley, 2000.7.18, Conley et al., 1998, Conley and Blair, 1996)

57E-57E

(determined by in situ hybridisation)

(Conley et al., 1997)

cv-2 lies at the joint of 57D with 57E.

(Conley et al., 1999)

Experimentally Determined Recombination Data

Location

2-95

(FlyBase, 2016)

2-101.3

(Comeron et al., 2012)

2-96.2

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

6302

6521

6524

63073

y¹ w^*; P{UAS-cv-2.R}8.3/CyO

6342

y¹ w^*; P{lacW}cv-2^225-3

54541

y¹ w^*; Mi{MIC}cv-2^MI10363

78332

w^*; cv-2^KO2/CyO, P{en1}wg^en11

34148

y¹ w^*; Mi{MIC}cv-2^MI01107/SM6a

63072

w^*; cv-2^K185 pr¹ cn¹/CyO

Kyoto

113667

w^*; P{GawB}cv-2^NP5302 / CyO, P{UAS-lacZ.UW14}UW14

VDRC

v109915

P{KK109295}VIE-260B

v2938

w¹¹¹⁸; P{GD1411}v2938

More stocks available...

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI20152

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000395

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000395

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

45280

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: cv-2 CG15671

(Blair, 2000.8.24, FlyBase, 1996-)

Additional comments

cv-2 is not allelic to Acox57D-d or Acox57D-p.

(Conley et al., 1999)

Source for merge of cv-2 CG15671 was sequence comparison ( date:000915 ).

(FlyBase, 1996-)

Other Comments

cv-2 may act extracellularly or in the secretory pathway to directly potentiate dpp or gbb signalling in the crossvein.

(Conley et al., 2000)

Mutations in cv-2 remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab.

(Diaz-Benjumea and Garcia-Bellido, 1990)

ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation.

(Diaz-Benjumea et al., 1989)

Origin and Etymology

Discoverer

Nicoletti, Oct. 1962.

Etymology

Identification

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45280

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W2H2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.