FB2020_06, released Dec 22, 2020

Gene: Dmel\cv-2

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General Information
Symbol
Dmel\cv-2
Species
D. melanogaster
Name
crossveinless 2
Annotation Symbol
CG15671
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000395
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Snapshot
crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Cv2, cv 2

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:21,355,015..21,379,464 [-]
Recombination map

2-95

RefSeq locus
NT_033778 REGION:21355015..21379464
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables BMP binding
inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490
(Serpe et al., 2008)
inferred from physical interaction with FLYBASE:gbb; FB:FBgn0024234
(Serpe et al., 2008)
enables BMP receptor binding
inferred from physical interaction with FLYBASE:tkv; FB:FBgn0003716
(Serpe et al., 2008)
enables heparan sulfate proteoglycan binding
inferred from genetic interaction with FLYBASE:botv; FB:FBgn0027535
(Serpe et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Conley et al., 2000)
involved_in positive regulation of BMP signaling pathway
inferred from mutant phenotype
(Serpe et al., 2008, Conley et al., 2000)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from direct assay
(Serpe et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
Positive Regulators of BMP Signaling Pathway -
Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
cv-2: crossveinless on chromosome 2
Anterior and posterior crossveins absent. RK1.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\cv-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cv-2-RA
FBtr0071610
NM_080070
4329
751
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
cv-2-PA
FBpp0071536
83.7
751
8.48
NP_524809
AAF46719
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cv-2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc | restricted
(Conley et al., 2000)
anterior-posterior compartment boundary of the wing disc
(Conley et al., 2000)
anterior-posterior compartment boundary of imaginal disc
(Serpe et al., 2008)
pupal stage P6
crossvein
(Conley et al., 2000)
crossvein | vicinity of
(Conley et al., 2000)
wing vein

Comment: at the tips

(Conley et al., 2000)
anterior crossvein
(Serpe et al., 2008)
posterior crossvein
(Wagner et al., 2010, Serpe et al., 2008)
wing vein | distal
(Serpe et al., 2008)
presumptive wing vein
(Wagner et al., 2010)
longitudinal vein
(Wagner et al., 2010)
embryonic stage 5
organism | dorsal
(Serpe et al., 2008)
Additional Descriptive Data

cv-2 expression is first visible broadly around the crossveins and the end of the longitudinal veins at 21-22 hr APF. It becomes stronger and refines to a narrow stripe at 28-29 hr APF.

(Wagner et al., 2010)

cv-2 transcripts are most prominent near the anterior-posterior compartment boundaries in third instar imaginal discs, in the anterior and posterior crossveins in pupal wings and at the distal edges of longitudinal wing veins. Heightened expression is also observed in the dorsal regions of early embryos.

(Serpe et al., 2008)

Weak general expression is seen at all stages. In late third instar larvae, cv-2 transcripts are observed in three regions of the prospective notum. One contains and lies distal to the posterior notopleural bristle (pNP) and lies posterior to the anterior notopleural bristle (aNP). One lies distal to the trichoid sensillum (tri1). Transcripts are emphasized along the AP boundary of the prospective wing blade. In pupal wings at 19 hrs APF, transcripts are seen in broad regions around the crossveins. These resolve into narrower regions by 28 hr APF. Increased expression is also observed at the tips of the longitudinal veins.

(Conley et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular region
inferred from direct assay
(Serpe et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cv-2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cv-2
Transgenic constructs containing regulatory region of cv-2
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4da.Switch.PT
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal - majority die | cold sensitive
viable
viable, with Scer\GAL4- :
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
visible
visible, with Scer\GAL4A9
visible, with Scer\GAL4en-e16E
visible | adult stage
visible | dominant
visible | recessive
Phenotype manifest in
Allele
anterior crossvein
anterior crossvein (with Df(2R)Pu-D17)
anterior crossvein | ectopic, with Scer\GAL4ap-md52
crossvein
posterior crossvein
posterior crossvein, with Scer\GAL4A9
posterior crossvein, with Scer\GAL4ap-md52
posterior crossvein, with Scer\GAL4en-e16E
wing
wing, with Scer\GAL4en-e16E
wing | posterior
wing vein
wing vein, with Scer\GAL4ap-md52
wing vein (with Df(2R)Pu-D17)
wing vein | ectopic, with Scer\GAL4A9
wing vein | ectopic, with Scer\GAL4ap-md52
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (25)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BMPER
12 of 15
Yes
Yes
Hsap\KCP
4 of 15
No
Yes
Hsap\FCGBP
3 of 15
No
No
Hsap\VWC2
3 of 15
No
Yes
Hsap\VWC2L
3 of 15
No
Yes
Hsap\MUC5AC
2 of 15
No
No
Hsap\MUC5B
2 of 15
No
No
Hsap\MUC6
2 of 15
No
No
Hsap\OTOG
2 of 15
No
No
Hsap\OTOGL
2 of 15
No
No
Hsap\TECTA
2 of 15
No
No
Hsap\VWCE
2 of 15
No
Yes
Hsap\ZAN
2 of 15
No
No
Hsap\CHRD
1 of 15
No
No
Hsap\CHRDL1
1 of 15
No
Yes
Hsap\CHRDL2
1 of 15
No
Yes
Hsap\COCH
1 of 15
No
Yes
Hsap\CRIM1
1 of 15
No
No
Hsap\FRAS1
1 of 15
No
No
Hsap\MUC2
1 of 15
No
No
Hsap\NDP
1 of 15
No
Yes
Hsap\NEFM
1 of 15
No
Yes
Hsap\SSPO
1 of 15
No
No
Hsap\VIT
1 of 15
No
Yes
Hsap\VWF
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (26)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Bmper
12 of 15
Yes
Yes
Mmus\Fcgbp
3 of 15
No
Yes
Mmus\Kcp
3 of 15
No
Yes
Mmus\Vwc2l
3 of 15
No
Yes
Mmus\Vwc2
3 of 15
No
Yes
Mmus\9530053A07Rik
2 of 15
No
No
Mmus\Muc5b
2 of 15
No
No
Mmus\Muc6
2 of 15
No
No
Mmus\Otogl
2 of 15
No
No
Mmus\Otog
2 of 15
No
No
Mmus\Sspo
2 of 15
No
No
Mmus\Tecta
2 of 15
No
No
Mmus\Vwce
2 of 15
No
Yes
Mmus\Zan
2 of 15
No
No
Mmus\Chrdl1
1 of 15
No
Yes
Mmus\Chrdl2
1 of 15
No
Yes
Mmus\Chrd
1 of 15
No
No
Mmus\Coch
1 of 15
No
Yes
Mmus\Crim1
1 of 15
No
No
Mmus\Fras1
1 of 15
No
No
Mmus\Muc2
1 of 15
No
No
Mmus\Muc5ac
1 of 15
No
No
Mmus\Ndp
1 of 15
No
Yes
Mmus\Nefm
1 of 15
No
Yes
Mmus\Vit
1 of 15
No
Yes
Mmus\Vwf
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
Rnor\Bmper
11 of 13
Yes
Yes
Rnor\Kcp
3 of 13
No
Yes
Rnor\Fcgbpl1
2 of 13
No
No
Rnor\Fcgbp
2 of 13
No
No
Rnor\Muc5b
2 of 13
No
No
Rnor\Otogl
2 of 13
No
No
Rnor\Otog
2 of 13
No
No
Rnor\Sspo
2 of 13
No
No
Rnor\Tecta
2 of 13
No
No
Rnor\Vwc2l
2 of 13
No
Yes
Rnor\Chrdl1
1 of 13
No
Yes
Rnor\Chrdl2
1 of 13
No
Yes
Rnor\Chrd
1 of 13
No
No
Rnor\Coch
1 of 13
No
Yes
Rnor\Crim1
1 of 13
No
No
Rnor\Fras1
1 of 13
No
Yes
Rnor\LOC100909913
1 of 13
No
Yes
Rnor\Ndp
1 of 13
No
Yes
Rnor\Vit
1 of 13
No
Yes
Rnor\Vwc2
1 of 13
No
Yes
Rnor\Vwf
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\bmper
7 of 12
Yes
Yes
Xtro\kcp
3 of 12
No
Yes
Xtro\fras1
2 of 12
No
Yes
Xtro\LOC100485197
2 of 12
No
No
Xtro\LOC100492852
2 of 12
No
No
Xtro\LOC100497909
2 of 12
No
No
Xtro\muc6
2 of 12
No
No
Xtro\otogl
2 of 12
No
No
Xtro\tecta.1
2 of 12
No
No
Xtro\vwc2l.2
2 of 12
No
Yes
Xtro\vwc2
2 of 12
No
Yes
Xtro\zan
2 of 12
No
No
Xtro\chrdl1
1 of 12
No
Yes
Xtro\coch
1 of 12
No
Yes
Xtro\crim1
1 of 12
No
No
Xtro\LOC101734551
1 of 12
No
Yes
Xtro\LOC108647325
1 of 12
No
Yes
Xtro\LOC108647384
1 of 12
No
Yes
Xtro\nefm
1 of 12
No
Yes
Xtro\vit
1 of 12
No
Yes
Xtro\vwf
1 of 12
No
No
Danio rerio (Zebrafish) (31)
Drer\bmper
8 of 15
Yes
Yes
Drer\si:dkey-266m15.6
4 of 15
No
Yes
Drer\si:dkey-283b1.7
3 of 15
No
Yes
Drer\vwc2
3 of 15
No
Yes
Drer\vwc2l
3 of 15
No
Yes
Drer\fras1
2 of 15
No
Yes
Drer\LOC100147849
2 of 15
No
No
Drer\muc5.1
2 of 15
No
No
Drer\muc5.2
2 of 15
No
No
Drer\muc5f
2 of 15
No
No
Drer\otogl
2 of 15
No
No
Drer\scospondin
2 of 15
No
No
Drer\si:ch211-39f2.3
2 of 15
No
No
Drer\si:dkey-65b12.6
2 of 15
No
No
Drer\tecta
2 of 15
No
No
Drer\zgc:113531
2 of 15
No
Yes
Drer\chrdl2
1 of 15
No
Yes
Drer\crim1
1 of 15
No
No
Drer\LOC100329651
1 of 15
No
No
Drer\LOC100536599
1 of 15
No
Yes
Drer\LOC101882112
1 of 15
No
Yes
Drer\LOC103911950
1 of 15
No
Yes
Drer\muc2.1
1 of 15
No
No
Drer\ndp
1 of 15
No
Yes
Drer\otog
1 of 15
No
No
Drer\si:ch73-329n5.6
1 of 15
No
Yes
Drer\si:ch211-182p11.1
1 of 15
No
Yes
Drer\si:ch1073-291c23.1
1 of 15
No
Yes
Drer\vwf
1 of 15
No
No
Drer\zanl
1 of 15
No
No
Drer\zgc:112964
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (20)
Cele\T01D3.6
3 of 15
Yes
Yes
Cele\B0507.1
1 of 15
No
Yes
Cele\C12D12.1
1 of 15
No
Yes
Cele\C16E9.1
1 of 15
No
Yes
Cele\C18H7.1
1 of 15
No
No
Cele\clec-199
1 of 15
No
Yes
Cele\crm-1
1 of 15
No
No
Cele\cutl-23
1 of 15
No
No
Cele\dct-17
1 of 15
No
Yes
Cele\dur-1
1 of 15
No
Yes
Cele\F19C6.3
1 of 15
No
No
Cele\F25E2.2
1 of 15
No
Yes
Cele\F32D8.3
1 of 15
No
No
Cele\F55D12.5
1 of 15
No
Yes
Cele\H13N06.2
1 of 15
No
Yes
Cele\irg-5
1 of 15
No
Yes
Cele\pals-39
1 of 15
No
Yes
Cele\R11G1.1
1 of 15
No
Yes
Cele\T09D3.3
1 of 15
No
Yes
Cele\Y8A9A.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CSS1
1 of 15
Yes
No
Scer\HPF1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902M2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002228
Drosophila simulans
Dsim\GD25201
Drosophila sechellia
Dsec\GM15724
Drosophila erecta
Dere\GG20779
Drosophila yakuba
Dyak\GE13717
Drosophila ananassae
Dana\GF12098
Drosophila pseudoobscura pseudoobscura
Dpse\GA13885
Drosophila persimilis
Dper\GL11845
Drosophila willistoni
Dwil\GK20745
Drosophila virilis
Dvir\GJ22320
Drosophila mojavensis
Dmoj\GI20470
Drosophila grimshawi
Dgri\GH21183
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502SH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012566
Glossina morsitans
Tsetse fly
Gmor\GMOY010943
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11362
Mayetiola destructor
Hessian fly
Mdes\Mdes004205
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018236
Anopheles darlingi
American malaria mosquito
Adar\ADAC003160
Anopheles gambiae
Malaria mosquito
Agam\AGAP006168
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017208
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F06 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006913
Danaus plexippus
Monarch butterfly
Dple\DPOGS213004-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213005-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012298
Apis florea
Little honeybee
Aflo\4257228564
Apis florea
Little honeybee
Aflo\2147488545
Apis mellifera
Western honey bee
Amel\GB43095
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22836
Bombus terrestris
Buff-tailed bumblebee
Bter\15210493
Linepithema humile
Argentine ant
Lhum\LH10999
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0028bf
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017398
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG027265
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014122
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009091
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02892
Tribolium castaneum
Red flour beetle
Tcas\cv-2
Pediculus humanus
Human body louse
Phum\PHUM222490
Rhodnius prolixus
Kissing bug
Rpro\cv-2
Cimex lectularius
Bed bug
Clec\CLEC003675
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006390
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI070321
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01811
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04Y2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002832
Ixodes scapularis
Black-legged tick
Isca\ISCW005085
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75470.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81699.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g03220
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_64092
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0O1O )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ecm/VWC/Vwd
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ecm/Tspn/Vwc/Vwd
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Vwd/Vwc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Vwdf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Vwdf_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000882
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016623
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000255
Gallus gallus
Domestic chicken
Ggal\BMPER
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (10)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Hml
2 of 10
Burs
1 of 10
CG13252
1 of 10
CG14692
1 of 10
Cpn
1 of 10
Muc14A
1 of 10
Rcd2
1 of 10
shot
1 of 10
sls
1 of 10
tnc
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BMPER; BMP binding endothelial regulator
    12 of 15
    608699
      KCP; kielin cysteine rich BMP regulator
      4 of 15
      609344
          FCGBP; Fc fragment of IgG binding protein
          3 of 15
          617553
              VWC2; von Willebrand factor C domain containing 2
              3 of 15
              611108
                  VWC2L; von Willebrand factor C domain containing 2 like
                  3 of 15
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      esyN Network Diagram
                      Show neighbor-neighbor interactions:
                      Select Layout:
                      Legend:
                      Protein
                      RNA
                      Selected Interactor(s)
                      Interactions Browser
                      View in Interactions Browser
                      Please see the Physical Interaction reports below for full details
                      protein-protein
                      Physical Interaction
                      Assay
                      References
                      cv-2 - dally
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Serpe et al., 2008)
                      cv-2 - dpp
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Serpe et al., 2008)
                      cv-2 - gbb
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Serpe et al., 2008)
                      cv-2 - tkv
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Serpe et al., 2008)
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      esyN Network Key:
                      Suppression
                      Enhancement
                      View in Interactions Browser
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      cv-2
                      suppressible
                      ash2
                      (Amoros et al., 2002)
                      cv-2
                      enhanceable
                      dpp
                      (Conley et al., 2000)
                      cv-2
                      enhanceable
                      gbb
                      (Conley et al., 2000)
                      cv-2
                      suppressible
                      ltl
                      (Szuperák et al., 2011)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      dpp
                      suppressible
                      cv-2
                      (Serpe et al., 2008)
                      gbb
                      suppressible
                      cv-2
                      (Serpe et al., 2008)
                      Gyc76C
                      suppressible
                      cv-2|cv|sog
                      (Schleede and Blair, 2015)
                      pbl
                      suppressible
                      cv-2
                      (Gregory et al., 2007)
                      sog
                      suppressible
                      cv-2
                      (Serpe et al., 2008, Ralston and Blair, 2005)
                      External Data
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Signaling Pathways (FlyBase)
                      Positive Regulators of BMP Signaling Pathway -
                      Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
                      Metabolic Pathways
                      External Data
                      Linkouts
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2R
                      Recombination map

                      2-95

                      Cytogenetic map
                      57D12-57E1
                      Sequence location
                      2R:21,355,015..21,379,464 [-]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      57D12-57E1
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      57E-57E
                      (determined by in situ hybridisation)
                      (Conley et al., 1997)
                      57E-57E
                      (Conley, 2000.7.18, Conley et al., 1998, Conley and Blair, 1996)
                      cv-2 lies at the joint of 57D with 57E.
                      (Conley et al., 1999)
                      Experimentally Determined Recombination Data
                      Location

                      2-95

                      (FlyBase, 2016)

                      2-101.3

                      (Comeron et al., 2012)

                      2-96.2

                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (20)
                      Genomic Clones (31)
                      cDNA Clones (11)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                        Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        DRSC - Results frm RNAi screens
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        Antibody Information
                        Laboratory Generated Antibodies
                         
                        Commercially Available Antibodies
                         
                        Other Information
                        Relationship to Other Genes
                        Source for database identify of
                        Source for database merge of

                        Source for merge of: cv-2 CG15671

                        (Blair, 2000.8.24, FlyBase, 1996-)
                        Additional comments

                        cv-2 is not allelic to Acox57D-d or Acox57D-p.

                        (Conley et al., 1999)

                        Source for merge of cv-2 CG15671 was sequence comparison ( date:000915 ).

                        (FlyBase, 1996-)
                        Other Comments

                        cv-2 may act extracellularly or in the secretory pathway to directly potentiate dpp or gbb signalling in the crossvein.

                        (Conley et al., 2000)

                        Mutations in cv-2 remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab.

                        (Diaz-Benjumea and Garcia-Bellido, 1990)

                        ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation.

                        (Diaz-Benjumea et al., 1989)
                        Origin and Etymology
                        Discoverer

                        Nicoletti, Oct. 1962.

                        Etymology
                        Identification
                        External Crossreferences and Linkouts ( 29 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        Flygut - An atlas of the Drosophila adult midgut
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        modMine - A data warehouse for the modENCODE project
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        FlyMine - An integrated database for Drosophila genomics
                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Synonyms and Secondary IDs (12)
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        References (105)