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Gene Dmel\cv-2

General Information
Symbol	Dmel\cv-2	Species	D. melanogaster
Name	crossveinless 2	Annotation symbol	CG15671
Feature type	protein_coding_gene	FlyBase ID	FBgn0000395
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	Cv 2
Genomic Location
Chromosome (arm)	2R	Recombination map	2-96.2
Cytogenetic map	57D12-57E1	Sequence location	2R:17,242,520..17,266,969 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crossveinless 2 is referred to in FlyBase by the symbol Dmel\cv-2 (CG15671, FBgn0000395). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing vein specification; imaginal disc-derived wing morphogenesis. 21 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; wing; crossvein; wing vein; anterior crossvein. It has one annotated transcript and one annotated polypeptide. Protein features are: Uncharacterised domain, cysteine-rich; von Willebrand factor, type C; von Willebrand factor, type D domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1635655_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cv-2. Gene sequence location is 2R:17242520..17266967.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cv-2: crossveinless on chromosome 2 Anterior and posterior crossveins absent. RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms cell surface binding heparan sulfate proteoglycan binding regulation of BMP signaling pathway BMP binding BMP receptor binding Alleles cv-2[KO2] cv-2[Scer\UAS.T:Hsap\MYC] cv-2[Un.Scer\UAS.T:Hsap\MYC.T:SV5\V5,T:Zzzz\His6] cv-2[KO1] cv-2[N.Scer\UAS.T:Avic\GFP-EGFP] cv-2[Scer\UAS.T:Hsap\MYC.T:SV5\V5,T:Zzzz\His6] cv-2[N.Scer\UAS] cv-2[Scer\UAS.cSa] cv-2[Un.Scer\UAS] cv-2[F1-42] Transgenic Constructs P{UAS-cv-2.S} P{UAS-cv2.MYC} P{UAS-cv-2.N} P{UAS-cv-2.MYC.V56His} P{UAS-cv-2.N.EGFP} P{UAS-cv-2.Un.MYC.V56His} P{UAS-cv-2.Un}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57D12-57E1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57E-57E     (Conley, 2000.7.18) 57E-57E     (Conley et al., 1998) 57E-57E   (determined by in situ hybridisation)   (Conley et al., 1997) 57E-57E     (Conley and Blair, 1996)   cv-2 lies at the joint of 57D with 57E.   (Conley et al., 1999)
Experimentally Determined Recombination Data
Location	2-96.2
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cv-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cv-2-RA FBtr0071610  NM_080070   4329   751
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cv-2-PA   FBpp0071536   83.7   751   8.48     NP_524809   AAF46719
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • von Willebrand factor, type C (IPR001007) von Willebrand factor, type D domain (IPR001846) Uncharacterised domain, cysteine-rich (IPR014853)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46719   AF288223   AQ025027   BI212133   BI483724   BI628623   BP545731   BT133425   CO291640   CO294560   CO328191   EC075330   EC212349   EC227743   EC251615
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W2H2 Q9GYX3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435226 2R:17,253,525..17,256,116 evidence=Reporter construct (in vivo) (Weiss et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    10.1 Larval Midgut    14.8 Larval Hindgut    11.7 Larval Malpighian Tubules    22.6 Larval Fat Body    10.8 Larval Salivary Gland    13.5 Larval Trachea    29.85 Larval Carcass    21.55 Adult Head    17.2 Adult Eye    15.85 Adult Brain    13.9 Adult Thoracic-Abdominal Ganglion    31 Adult Crop    11.2 Adult Midgut    18.3 Adult Hindgut    25 Adult Malpighian Tubules    11.3 Adult Fat Body    28.2 Adult Salivary Gland    18.3 Adult Heart    10.95 Adult VirginFemale Spermatheca    10.2 Adult InseminatedFemale Spermatheca    9.7 Adult Ovary    3.2 Adult Testis    2.5 Adult Male Accessory Gland    11.3 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    13.9   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    31   NA  Crop    no informative data   no informative data  Midgut    no informative data   11.7  Hindgut    25   22.6  Malpighian Tubules    no informative data   no informative data  Fat Body    28.2   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   29.85  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    9.7   NA  Ovary    3.2   NA  Testis    2.5   NA  Male Accessory Gland    no informative data   21.55  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    6 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    8 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    3 digestive system, 4-day adult    6 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    14 embryo 04-06hr    25 embryo 06-08hr    10 embryo 08-10hr    9 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    10 embryo 16-18hr    15 embryo 18-20hr    17 embryo 20-22hr    12 embryo 22-24hr    13 larva L1    7 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    9 white prepupae 12hr    11 white prepupae 24hr    21 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    12 adult male 01day    7 adult male 05day    6 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H    36 embryonic GM2    29 embryonic Kc167    153 embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    37 ovary fGS/OSS    6 ovary OSC    30 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H  (36) embryonic GM2  (29) embryonic Kc167  (153) embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (37) ovary fGS/OSS    6 ovary OSC  (30) ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H    36 embryonic GM2    29 embryonic Kc167  (153) embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    37 ovary fGS/OSS    6 ovary OSC    30 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H    36 embryonic GM2    29 embryonic Kc167    153 embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    37 ovary fGS/OSS    6 ovary OSC    30 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H    36 embryonic GM2    29 embryonic Kc167    153 embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    37 ovary fGS/OSS    6 ovary OSC    30 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H  (36) embryonic GM2  29 embryonic Kc167  (153) embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (37) ovary fGS/OSS    6 ovary OSC  30 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H    36 embryonic GM2    29 embryonic Kc167  (153) embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    37 ovary fGS/OSS    6 ovary OSC    30 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    14 embryonic 1182-4H    36 embryonic GM2    29 embryonic Kc167    153 embryonic S1    12 embryonic S3    1 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    23 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    37 ovary fGS/OSS    6 ovary OSC    30 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000395 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15671-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4da.Switch.PT cv-2GX6589 partially lethal - majority die | cold sensitive cv-2F1-42 cv-2KO1 cv-2KO2 viable cv-2F1-42 cv-2KO1 cv-2KO2 viable, with Scer\GAL4[-]: cv-2EP1103 viable, with Scer\GAL4pnr-MD237 cv-2GD1411 Other Phenotypes Allele visible cv-21 visible, with Scer\GAL4A9 cv-2Scer\UAS.cSa cv-2Un.Scer\UAS visible, with Scer\GAL4en-e16E cv-2Scer\UAS.cBa cv-2Scer\UAS.cSa visible | adult stage cv-2F1-42 cv-2KO1 cv-2KO2 visible | dominant cv-2225-3 visible | recessive cv-2M1 Phenotype manifest in Allele anterior crossvein cv-21 cv-2M1 cv-2F1-42 cv-2KO2 cv-2KO1 anterior crossvein (with Df(2R)Pu-D17) cv-21 cv-2k03511 anterior crossvein | ectopic, with Scer\GAL4ap-md52 cv-2EP1103 crossvein cv-21 posterior crossvein cv-21 cv-2225-3 cv-2M1 cv-2F1-42 cv-2KO2 cv-2KO1 posterior crossvein, with Scer\GAL4A9 cv-2Scer\UAS.cSa posterior crossvein, with Scer\GAL4ap-md52 cv-2EP1103 posterior crossvein, with Scer\GAL4en-e16E cv-2Scer\UAS.cBa cv-2Scer\UAS.cSa wing cv-2F1-42 cv-2KO2 cv-2KO1 wing, with Scer\GAL4en-e16E cv-2Scer\UAS.cBa wing | posterior cv-2225-3 wing vein cv-2F1-42 cv-2KO2 cv-2KO1 wing vein, with Scer\GAL4ap-md52 cv-2EP1103 wing vein (with Df(2R)Pu-D17) cv-21 wing vein | ectopic, with Scer\GAL4A9 cv-2Scer\UAS.cSa cv-2Un.Scer\UAS wing vein | ectopic, with Scer\GAL4ap-md52 cv-2EP1103
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of cv-2 Class Mutagen Stocks Known lesion cv-21 spontaneous 3 -- cv-2225-3 P-element activity 1 Yes cv-2DP00071 1 -- cv-2MI01107 1 -- cv-2NP0294 1 -- cv-2NP5302 1 -- cv-2NP7367 1 -- cv-2d08665 0 -- cv-2DG25710 0 -- cv-2EP1103 P-element activity 0 Yes cv-2EP2634 0 -- cv-2F1-42 ends-in gene targeting FLPase SCEI endonuclease 0 Yes cv-2GS9538 0 Yes cv-2GX6589 Delta2-3 0 -- cv-2k03511 P-element activity 0 Yes cv-2KO1 ends-in gene targeting FLPase SCEI endonuclease I-CreI endonuclease 0 Yes cv-2KO2 ends-in gene targeting FLPase SCEI endonuclease I-CreI endonuclease 0 Yes cv-2M1 0 -- cv-2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cv-2 Class Mutagen Stocks Known lesion cv-2GD1411 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-2HMS01656 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cv-2KK109295 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cv-2N.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-2N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-2Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes cv-2Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes cv-2Scer\UAS.cVa in vitro construct - regulatory fusion 0 Yes cv-2Scer\UAS.T:Hsap\MYC.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-2Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cv-2Un.Scer\UAS.T:Hsap\MYC.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes cv-2Un.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6074 (Ryder, 2004.4.26) Df(2R)Exel6075 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1411} NA P{KK109295} NA P{TRiP.HMS01656} NA P{UAS-cv-2.B} NA P{UAS-cv-2.MYC.V56His} NA P{UAS-cv2.MYC} NA P{UAS-cv-2.N.EGFP} NA P{UAS-cv-2.N} NA P{UAS-cv-2.S} NA P{UAS-cv-2.Un.MYC.V56His} NA P{UAS-cv-2.Un} NA P{UAS-cv-2.V} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cv-2EP1103 NA P{EP}cv-2EP2634 NA P{EP}cv-2GX6589 NA P{GSV6}cv-2GS9538 NA P{Mae-UAS.6.11}cv-2DP00071 NA P{XP}cv-2d08665 NA insertion of enhancer trap binary system P{GawB}cv-2NP0294 No P{GawB}cv-2NP5302 No P{GawB}cv-2NP7367 No insertion of enhancer trap P{lacW}cv-2225-3 No P{lacW}cv-2k03511 No miscellaneous insertions Mi{MIC}cv-2MI01107 NA P{wHy}cv-2DG25710 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
BMP binding inferred from physical interaction with dpp (Serpe et al., 2008) inferred from physical interaction with gbb (Serpe et al., 2008) BMP receptor binding inferred from physical interaction with tkv (Serpe et al., 2008) cell surface binding inferred from direct assay (Serpe et al., 2008) heparan sulfate proteoglycan binding inferred from genetic interaction with botv (Serpe et al., 2008)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) imaginal disc-derived wing vein specification inferred from mutant phenotype (Conley et al., 2000) regulation of BMP signaling pathway inferred from genetic interaction with sog (Serpe et al., 2008) inferred from physical interaction with dpp (Serpe et al., 2008) inferred from physical interaction with gbb (Serpe et al., 2008) inferred from physical interaction with tkv (Serpe et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cv-2 allele Gene References cv-2225-3 gbb (Conley et al., 2000) cv-2EP1103 sog (Ralston and Blair, 2005) cv-2k03511 dpp (Conley et al., 2000) gbb (Conley et al., 2000) unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69559 DroID - A comprehensive database of gene and protein interactions. • FBgn0000395 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45280
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NGH66 Dipteran inclusive ortholog search EOG6CJVR8 Insect inclusive ortholog search EOG60VTJK Arthropod inclusive ortholog search EOG6BCC31 Metazoa inclusive ortholog search EOG6TTV9W
Orthologs in Drosophila Species (EOG6NGH66)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cv-2     Drosophila simulans   Dsim\GD25201 Y   Drosophila sechellia   Dsec\GM15724 Y   Drosophila erecta   Dere\GG20779 Y   Drosophila yakuba   Dyak\GE13717 Y   Drosophila ananassae   Dana\GF12098 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13885 Y   Drosophila persimilis   Dper\GL11845 Y   Drosophila willistoni   Dwil\GK20745 Y   Drosophila virilis   Dvir\GJ22320 Y   Drosophila mojavensis   Dmoj\GI20470 Y   Drosophila grimshawi   Dgri\GH21183 Y
Orthologs in non-Drosophila Dipterans (EOG6CJVR8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001450   Anopheles gambiae Malaria mosquito  Agam\AGAP006168   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017208
Orthologs in non-Dipteran Insects (EOG60VTJK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43095   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027265   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017398   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014122   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009091   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10292   Atta cephalotes Leafcutter ant  Acep\ACEP20877   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18994   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22390   Linepithema humile Argentine ant  Lhum\LH10999   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17943   Solenopsis invicta Red fire ant  Sinv\SINV25494   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006390   Acyrthosiphon pisum Pea aphid  Apim\ACYPI070321   Bombyx mori Silkmoth  Bmor\BGIBMGA006913   Pediculus humanus Human body louse  Phum\PHUM222490   Tribolium castaneum Red flour beetle  Tcas\cv-2
Orthologs in non-Insect Arthropods (EOG6BCC31)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\SAMSN1   Ixodes scapularis Deer tick  Isca\ISCW005085
Orthologs in non-Arthropod Metazoa (EOG6TTV9W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004940gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000782gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020181gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000957gn   Danio rerio Zebrafish  Drer\si:dkey-266m15.6   Danio rerio Zebrafish  Drer\bmper   Xenopus tropicalis Western clawed frog  Xtro\bmper   Xenopus tropicalis Western clawed frog  Xtro\kcp   Gallus gallus Domestic chicken  Ggal\BMPER   Mus musculus House mouse  Mmus\Bmper   Mus musculus House mouse  Mmus\Kcp   Rattus norvegicus Norway rat  Rnor\Kcp   Rattus norvegicus Norway rat  Rnor\Bmper   Homo sapiens Human  Hsap\BMPER
Human Orthologs (1)
Gene OMIM HGNC Hsap\BMPER
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25201 Drosophila sechellia Dsec\GM15724 Drosophila erecta Dere\GG20779 Drosophila yakuba Dyak\GE13717 Drosophila ananassae Dana\GF12098 Drosophila pseudoobscura pseudoobscura Dpse\GA13885 Drosophila persimilis Dper\GL11845 Drosophila willistoni Dwil\GK20745 Drosophila virilis Dvir\GJ22320 Drosophila mojavensis Dmoj\GI20470 Drosophila grimshawi Dgri\GH21183
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	6302 cv-21 6521 l(2)57Cb1 cv-21/SM1 6524 l(2)57Ce1 cv-21/SM1 6342 y1 w*; P{lacW}cv-2225-3 34148 y1 w*; Mi{MIC}cv-2MI01107/SM6a 37514 y1 sc* v1; P{TRiP.HMS01656}attP40 21793 y1 w67c23; P{Mae-UAS.6.11}cv-2DP00071/CyO
Kyoto	113667 w*; P{GawB}cv-2NP5302 / CyO, P{UAS-lacZ.UW14}UW14 105438 y* w*; P{GawB}cv-2NP7367 / CyO, P{UAS-lacZ.UW14}UW14 112129 y* w*; P{GawB}cv-2NP0294 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v2938 w1118; P{GD1411}v2938
Genomic Clones ( 1 )
	BACR48K03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	FI20152
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE17156 RE66648 RH57123
Other clones	70330 75193 190221 214341.60 EK197857 EK207210 EP08727 FGC032H08
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000395 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45280
Antibody Information
Other Information
Discoverer
	Nicoletti, Oct. 1962.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cv-2 CG15671 (Blair, 2000.8.24, FlyBase, 1996-)
Additional comments	cv-2 is not allelic to Acox57D-d or Acox57D-p. (Conley et al., 1999) Source for merge of cv-2 CG15671 was sequence comparison (date:000915). (FlyBase, 1996-)
Other Comments
	cv-2 may act extracellularly or in the secretory pathway to directly potentiate dpp or gbb signalling in the crossvein. (Conley et al., 2000) Mutations in cv-2 remove transverse veins or crossveins: crossvein specific. Shows additive interactions with vn, ve, ci, cg, shv, ast, H, Vno, vvl, ri, tg, tt and ab. (Diaz-Benjumea and Garcia-Bellido, 1990) ri, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and have small lanceolate wings. Genes are involved in whole vein region-specification rather than vein differentiation. (Diaz-Benjumea et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080070 RefSeq (Proteins) • NP_524809 DDBJ / EMBL / GenBank • AAF46719 AAG01337 AF288223 AQ025027 Entrez Gene - A searchable database of RefSeq genes. • 45280 UniProtKB/TrEMBL • Q9GYX3 Q9W2H2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • von Willebrand factor, type C (IPR001007) von Willebrand factor, type D domain (IPR001846) Uncharacterised domain, cysteine-rich (IPR014853)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69559 DroID - A comprehensive database of gene and protein interactions. • FBgn0000395 DRSC - Results from RNAi screens. • FBgn0000395 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000395 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15671-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000395 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45280 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/crosvan1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45280 modMine - Data generated by the modENCODE project. • FBgn0000395
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BMPER (Krejcí et al., 2009) CG15671 (Ni et al., 2011.7.19, Keleman et al., 2009.8.5) CT35855 (Hynes and Zhao, 2000) Cv2 (Whitman, 2005) Cv 2 (Ralston and Blair, 2002) cv 2 (Ralston et al., 2002, Olson and Blair, 2002) cv-2 (Dworkin and Gibson., 2006, Biemar et al., 2006, Dworkin and Gibson, 2006, Szuperák et al., 2011, Devineni et al., 2011, Layalle et al., 2011, Serpe et al., 2008, Parrish et al., 2007, Krejcí et al., 2009, Verdier et al., 2006, Jaramillo et al., 2009, Wagner et al., 2010, Beltran et al., 2007, Pilgram et al., 2011, Weiss et al., 2010, Paik et al., 2012) Cv-2 (Karim et al., 2012)
Name Synonym	crossveinless 2   crossveinless-2 (Biemar et al., 2006, Gregory et al., 2007, Dworkin and Gibson, 2006, Jaramillo et al., 2009, Wagner et al., 2010, Weiss et al., 2010) Crossveinless 2 (Serpe et al., 2008)
Secondary FlyBase IDs
	FBgn0034625
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 6 )
	Karim et al., 2012, J. R. Soc. Interface 9(70): 1073--1083 Secreted, receptor-associated bone morphogenetic protein regulators reduce stochastic noise intrinsic to many extracellular morphogen distributions. [FBrf0217860] Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245 Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389] Devineni et al., 2011, Fly 5(3): 191--199 The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. [FBrf0214716] Layalle et al., 2011, Development 138(11): 2315--2323 Engrailed homeoprotein acts as a signaling molecule in the developing fly. [FBrf0213689] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Szuperák et al., 2011, Development 138(4): 715--724 Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida. [FBrf0212881] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...