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Gene Dmel\Cy

General Information
Symbol	Dmel\Cy	Species	D. melanogaster
Name	Curly	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0000403
Gene Model Status	Unannotated	Stock availability	365 publicly available
Genomic Location
Chromosome (arm)		Recombination map	2-6.1
Cytogenetic map	23A4-23B2	Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene Curly is referred to in FlyBase by the symbol Dmel\Cy (FBgn0000403). It is a gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing morphogenesis. 27 alleles are reported. The phenotype of these alleles is annotated with: wing. It has no annotated transcripts. Gene has not been localized to the genome sequence.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Cy: Curly Cy: Curly From L. Ward, 1923, Genetics 8: 276-300. Wings curled upward; rarely overlaps wild type at 25, but frequently overlaps at 19. Curvature caused by the unequal contraction of the upper and lower epithelia during the drying period following emergence from the pupa case (Waddington, 1940, J. Genet. 41: 75-139). Flightless but thoracic innervation normal (Chiarodo, Reing, and Saranchak, 1971, J. Expt. Zool. 178: 325-30). Expression decreased by larval crowding, increased by increased temperature during pupal development (Nozawa, 1956, Jpn. J. Genet. 31: 161-71). Classifiable in single dose in triploids. Usually homozygous lethal but may emerge as dwarf with more extreme wing character. Effective lethal phase late embryo-early larva (Kidwell, 1972, J. Hered. 63: 100). RK1A.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23A4-23B2   Left limit from complementation mapping relative to l(2)23Ab (citation unavailable) Right limit from inclusion within Df(2L)DTD2 (citation unavailable)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-6.1 (Tinderholt, 1961)
Left of (cM)	l(2)23AB7 (Littleton and Bellen, 1994)
Right of (cM)
Notes	Mapped after having been removed from In(2L)Cy. (Tinderholt, 1961)
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{KZ.TRAP}KZ1941 Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   embryonic/larval fat body   (Littleton and Bellen, 1994)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Cy66.5 Cy66.14 Cy67.3 CyD12 CyD13 CyD21 CyD25 CyT16 CyT18 CyT25 CyT31 CyT32 CyT37 CyT38 CyT43 CyT51 CyT61 CyT62 Other Phenotypes Allele wild-type CyRev76 Phenotype manifest in Allele wing Cy1
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of Cy Class Mutagen Stocks Known lesion Cy1 spontaneous 362 -- Cy67.3 1 -- CyK ethyl methanesulfonate 1 -- Cy66.14 0 -- Cy66.5 0 -- CyD12 ethyl methanesulfonate 0 -- CyD13 ethyl methanesulfonate 0 -- CyD21 ethyl methanesulfonate 0 -- CyD25 ethyl methanesulfonate 0 -- Cydrv1 gamma ray 0 -- CyM 0 -- CyRev76 X ray 0 -- Cyrv11 gamma ray 0 -- Cyrv27 gamma ray 0 -- Cyrv67 gamma ray 0 -- CyT16 ethyl methanesulfonate 0 -- CyT18 ethyl methanesulfonate 0 -- CyT25 ethyl methanesulfonate 0 -- CyT31 ethyl methanesulfonate 0 -- CyT32 ethyl methanesulfonate 0 -- CyT37 ethyl methanesulfonate 0 -- CyT38 ethyl methanesulfonate 0 -- CyT43 ethyl methanesulfonate 0 -- CyT51 ethyl methanesulfonate 0 -- CyT61 ethyl methanesulfonate 0 -- CyT62 ethyl methanesulfonate 0 -- Cyunspecified 0 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cy Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Disrupted in	Df(2L)C144 (Stefancsik, 2002.5.22, DiAntonio et al., 1993) Df(2L)DTD2 (Spencer et al., 1982, DiAntonio et al., 1993, Littleton and Bellen, 1994) Df(2L)JS31 (Stefancsik, 2002.5.22)
Not disrupted in	Df(2L)dppd19 (Spencer et al., 1982) Df(2L)dppd21 (Spencer et al., 1982) Df(2L)dpp-H34 (DiAntonio et al., 1993) Df(2L)DTD48 (Spencer et al., 1982) Df(2L)JS17 (Stefancsik, 2002.5.22) Df(2L)N6 (Stefancsik, 2002.5.22) Df(2L)N19 (Littleton and Bellen, 1994) In(2LR)dppd23LDTD21R (Spencer et al., 1982)
Duplicated in	Dp(2;2)dppd13 (Spencer et al., 1982)
Not duplicated in	Dp(2;2)dppd21 (Spencer et al., 1982) Dp(2;2)DTD48 (Spencer et al., 1982)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{KZ.TRAP}KZ1941 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Waddington, 1940)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cy allele Gene References Cy1 Bl (Meyer, 1952) Su(Cy) (Thompson, 1963) unspecified dpy
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000403
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 365 )
Bloomington	26167 CyK/In(2LR)Gla 880 T(2;3)Scar, Scar1/Cy1 832 T(1;2)lt/In(2L)Cy, In(2R)Cy, Cy1 359 nw2/In(2L)Cy, In(2R)NS, Cy1 3548 Df(2L)al, dsal/In(2L)Cy, Cy1 382 ade210/In(2L)Cy, In(2R)Cy, Cy1
Kyoto	101514 In(2L)Cy In(2R)NS, Cy1 / nw2 106869 Df(2L)esc-P2-0/Cy1 amosRoi-1 106870 Df(2L)esc-P3-0/Cy1 amosRoi-1 107090 Df(2L)al, dsal/In(2L)Cy, Cy1 125138 w1118; P{RS5}ttv5-HA-1202 / Cy 105881 ade210/In(2L)Cy, In(2R)Cy, Cy1
	More stocks available...
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43939
Antibody Information
Other Information
Discoverer
	L. Ward, March 1920.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Flies bearing dominant Cy mutations lose the curly wing phenotype when exposed to fluorescent light. There are two sensitive periods for this effect: late embryogenesis and the first half of the pupal stage. Daylight and standard tungsten light do not have the suppressive effect. (Pavelka et al., 1995) In a screen for lethal mutations that fail to complement Df(2L)C144, several mutations were isolated that showed some interaction with existing Cy alleles. (DiAntonio et al., 1993) Phenotypic variation of the genetic components underlying oviposition behaviour is analysed using the complete diallel mating design. (Ruiz-Dubreuil and del Solar, 1993) Cy removed from In(2L)Cy still causes a local reduction in crossing over in the ed-cl region (Sederoff).
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000403 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43939
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Cy (Siegel et al., 2004, Cook, 2008.12.1) l(2)23Bb (Hartenstein et al., 1997, )
Name Synonym	Curly (Siegel et al., 2004)
Secondary FlyBase IDs
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 23 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Book  ( 2 ) Teaching note  ( 1 ) Stock list  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...