FB2025_02 , released April 17, 2025
Gene: Dmel\CycA
Open Close
General Information
Symbol
Dmel\CycA
Species
D. melanogaster
Name
Cyclin A
Annotation Symbol
CG5940
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000404
Gene Model Status
Current
Stock Availability
31 publicly available
Gene Summary
Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Cyc A, DmcycA, dCycA, rsg11

Key Links
Genomic Location
Cytogenetic map
68E1-68E1
Sequence location
Recombination map
3-37
RefSeq locus
NT_037436 REGION:11826719..11833578
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables cyclin-dependent protein serine/threonine kinase regulator activity
inferred from direct assay
(Maldonado-Codina and Glover, 1992)
enables protein binding
inferred from physical interaction with FLYBASE:Z600; FB:FBgn0004052
(Gawlinski et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cyclin-dependent protein serine/threonine kinase regulator activity
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
non-traceable author statement
(Lehner and O'Farrell, 1989)
Biological Process (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in asymmetric neuroblast division
inferred from mutant phenotype
(Bhalerao et al., 2005)
involved_in G1/S transition of mitotic cell cycle
inferred from mutant phenotype
(Kim et al., 2017)
involved_in mitotic cell cycle
inferred from mutant phenotype
(Jacobs et al., 2001)
involved_in mitotic sister chromatid segregation
inferred from mutant phenotype
(Parry and O'Farrell, 2001)
involved_in positive regulation of stem cell differentiation
inferred from mutant phenotype
(Ji et al., 2017)
involved_in regulation of exit from mitosis
inferred from mutant phenotype
(Reber et al., 2006)
involved_in regulation of mitotic cell cycle, embryonic
inferred from mutant phenotype
(Reber et al., 2006)
involved_in regulation of mitotic nuclear division
inferred from expression pattern
(Lehner and O'Farrell, 1989)
involved_in syncytial blastoderm mitotic cell cycle
inferred from genetic interaction with FLYBASE:CycB; FB:FBgn0000405,FLYBASE:CycB3; FB:FBgn0015625
(McCleland and O'Farrell, 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in G1/S transition of mitotic cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Yuan et al., 2012, Avedisov et al., 2000)
inferred from direct assay
(Lehner and O'Farrell, 1989)
located_in cytosol
inferred from direct assay
(Foley et al., 1999)
located_in fusome
inferred from direct assay
(Varadarajan et al., 2016)
located_in male germ cell nucleus
inferred from direct assay
(Varadarajan et al., 2016)
located_in nucleus
inferred from direct assay
(Yuan et al., 2012, Avedisov et al., 2000, Foley et al., 1999)
inferred from direct assay
(Lehner and O'Farrell, 1989)
located_in spectrosome
inferred from direct assay
(Yuan et al., 2012)
located_in synapse
inferred from direct assay
(Afonso et al., 2015)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
part_of cyclin A2-CDK2 complex
inferred from biological aspect of ancestor with PANTHER:PTN000020367
(GO Reference Genome Project, 2011-)
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
is_active_in microtubule organizing center
inferred from biological aspect of ancestor with PANTHER:PTN007424001
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cyclin family. Cyclin AB subfamily. (P14785)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the Cdk1 and Cdk2 protein kinases to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
(UniProt, P14785)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
CycA: Cyclin A
Encodes cyclin, a molecule involved in the cell cycle; the pattern of transcription reflects this. Maternal message uniformly distributed in newly laid egg, but becomes more concentrated in the cortex prior to peripheral nuclear migration. At the time of cellularization of the blastoderm, zygotic message is produced. Cyclin A accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded during metaphase. A functional cyclin A gene is required for continued cell division after exhaustion of maternally provided cyclin A. Message confined to dividing tissues in brain and imaginal disks in larvae.
Summary (Interactive Fly)

a a G2-M phase cyclin - cell cycle regulator - dimerization partner of Cdk1/Cdc2 kinase - during the G2 phase the CycA-Cdk1 prevents premature DNA re-replication - during mitosis and G1, CycA is rapidly degraded resulting in inactivation of Cdk1 protein kinase activity

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CycA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P14785)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CycA-RA
FBtr0076075
NM_079306
2555
491
CycA-RC
FBtr0304650
NM_001259795
2916
490
Additional Transcript Data and Comments
Reported size (kB)

2.504 (longest cDNA)

(Takahisa et al., 1992)

3.0, 2.7 (northern blot)

(Lehner and O'Farrell, 1989)

2.5, 2.3 (northern blot)

(Whitfield et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CycA-PA
FBpp0075807
56.2
491
5.73
P14785
NP_524030
AAF49999
CycA-PC
FBpp0293192
56.0
490
5.73
M9NFR3
NP_001246724
AFH04395
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

491 (aa)

(Takahisa et al., 1992)

60 (kD)

(Whitfield et al., 1990)

491 (aa); 61 (kD)

(Lehner and O'Farrell, 1989)
Comments

CycA protein levels increase in eye discs in response to ectopic expression of Rca1.

(Dong et al., 1997)
External Data
Subunit Structure (UniProtKB)

Component of the Frs-CycA-Cdk1 complex composed of CycA, Cdk1 and Z600 (PubMed:17431409). Interacts (via C-terminus) with Z600 (PubMed:17431409). Interacts with otu and (via C-terminus) with bam; the interaction stabilizes CycA by negatively regulating its ubiquitination (PubMed:28484036).

(UniProt, P14785)
Post Translational Modification

Ubiquitinated (PubMed:28484036). Ubiquitination state is negatively regulated by a deubiquitinase complex made up of bam and otu (PubMed:28484036).

(UniProt, P14785)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycA using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.12

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 2 -- 6
organism | ubiquitous
(Whitfield et al., 1989)
embryonic stage 4
organism
(Lecuyer et al., 2007)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 5
primordial germ cell
(Lecuyer et al., 2007)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal sensory complex primordium
(Fisher et al., 2012)
embryonic ganglion mother cell
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic stage 15
ventral nerve cord
(Magalhaes et al., 2007)
adult stage | male
testis | restricted
(Morris et al., 2009, Perezgasga et al., 2004)
spermatogenesis & adult stage | male
spermatocyte
(Lu et al., 2013)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Lehner and O'Farrell, 1989)
embryonic stage -- adult stage
(Whitfield et al., 1989)
embryonic stage 1 -- 2
(Whitfield et al., 1989)
larval stage
imaginal disc
(Whitfield et al., 1989)
larval brain
(Whitfield et al., 1989)
adult stage | female
ovary
(Dalby and Glover, 1992)
(Dalby and Glover, 1992, Whitfield et al., 1989)
adult stage & oogenesis
germarium
(Dalby and Glover, 1992)
oogenesis stage S9 -- S10 & adult stage | female
nurse cell
(Dalby and Glover, 1992)
Additional Descriptive Data
Marker for
 
testis
(Perezgasga et al., 2004)
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Lehner and O'Farrell, 1989)
larval stage
larval central nervous system
(Whitfield et al., 1990)
imaginal disc
(Lehner and O'Farrell, 1989)
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of adult brain | restricted
(Afonso et al., 2015)
neuron | subset of adult pars lateralis
• synapse
(Afonso et al., 2015)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
cell | subset

Comment: interphase cells

(Foley et al., 1999)
embryonic stage 4
(Maldonado-Codina and Glover, 1992)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
peripheral nervous system
(Lehner and O'Farrell, 1989)
(Whitfield et al., 1990)
embryonic stage 1 -- 12
organism
(Lehner and O'Farrell, 1989)
Additional Descriptive Data

The cyclins are normally found in the cytoplasm of interphase cells and become nuclear in prophase cells. CycA protein is abruptly degraded and is not detectable in metaphase or anaphase cells. Cells of embryos heat shocked in G2 phase of cycle 14 show very high levels of the cyclins and cyclin degradation is delayed: heat shock causes a disruption in cell cycle progression.

(Afonso et al., 2015, Maldonado-Codina et al., 1993)

The highest CycA protein concentration is found in the cytoplasm at interphase. CycA protein associates with chromatin during mitosis. It is not completely degraded at the metaphase-anaphase transition in syncytial embryos.

(Maldonado-Codina and Glover, 1992, Lehner and O'Farrell, 1989)

CycA protein is initially distributed uniformly throughout the syncytial embryo. It becomes concentrated in the cortex in a 30-40 micron deep layer as nuclei migrate to the surface.

(Maldonado-Codina and Glover, 1992)

CycA protein appears to be concentrated over the region of the condensing chromatin in prophase cells. CycA protein accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded within metaphase.

(Whitfield et al., 1990, Lehner and O'Farrell, 1989)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Yuan et al., 2012, Avedisov et al., 2000)
inferred from direct assay
(Lehner and O'Farrell, 1989)
located_in cytosol
inferred from direct assay
(Foley et al., 1999)
located_in fusome
inferred from direct assay
(Varadarajan et al., 2016)
located_in male germ cell nucleus
inferred from direct assay
(Varadarajan et al., 2016)
located_in nucleus
inferred from direct assay
(Yuan et al., 2012, Avedisov et al., 2000, Foley et al., 1999)
inferred from direct assay
(Lehner and O'Farrell, 1989)
located_in spectrosome
inferred from direct assay
(Yuan et al., 2012)
located_in synapse
inferred from direct assay
(Afonso et al., 2015)
Expression Deduced from Reporters
Reporter: P{lacW}CycAS003302a
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval peripheral nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS010407
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
embryonic stage 6 -- 9
mesoderm
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS024534
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS052106
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS052118
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS052119
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS054513
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS132916
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9
neuroblast
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS144905
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS144911
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Salzberg et al., 1997)
Reporter: P{lacW}CycAS144914
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Salzberg et al., 1997)
Reporter: P{PZ}CycA03946
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
imaginal disc
(Meister and Braun, 1995.10)
larval brain
(Meister and Braun, 1995.10)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycA in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 47 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 49 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CycA
Transgenic constructs containing regulatory region of CycA
Aberrations (Deficiencies and Duplications) ( 16 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal (with Df(3L)vin7)
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage, with Scer\GAL4Su(H).GBE
lethal - all die during embryonic stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal, with Scer\GAL4da.G32
partially lethal - majority die
partially lethal - majority die | recessive
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell migration
abnormal meiotic cell cycle, with Scer\GAL4VP16.bam
abnormal mitotic cell cycle
abnormal mitotic cell cycle, with Scer\GAL4prd.RG1
abnormal mitotic cell cycle | embryonic stage
abnormal mitotic cell cycle | embryonic stage (with CycA3)
abnormal mitotic cell cycle | embryonic stage (with CycA5)
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size | adult stage, with Scer\GAL4ey.PU
abnormal size | embryonic stage | somatic clone
abnormal sleep | dominant
decreased cell number | embryonic stage
decreased occurrence of cell division | adult stage, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
decreased occurrence of cell division | embryonic stage
decreased occurrence of cell division | embryonic stage | somatic clone
decreased occurrence of cell division | somatic clone | third instar larval stage
decreased sleep | adult stage, with Scer\GAL4elav.PU
increased cell size | embryonic stage
increased occurrence of cell division, with Scer\GAL4hs.2sev
increased occurrence of cell division | adult stage
increased occurrence of cell division | embryonic stage
increased occurrence of cell division | embryonic stage, with Scer\GAL4prd.RG1
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PF
increased occurrence of cell division | third instar larval stage
short lived, with Scer\GAL4elav.PU
some die during embryonic stage | recessive
some die during immature adult stage | recessive
some die during larval stage | recessive
visible, with Scer\GAL4da.G32
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4ey.PU
visible | recessive
wild-type
Phenotype manifest in
Allele
abdominal neuroblast NB6-4
abdominal segment 2 & cardioblast
abdominal segment 3 & cardioblast
abdominal segment 4 & cardioblast
abdominal segment 5 & cardioblast
abdominal segment 6 & cardioblast
abdominal segment 7 & cardioblast
adult midgut, with Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE
amnioserosa
anaphase & condensed nuclear chromosome
cell cycle
chaeta, with Scer\GAL4da.G32
chaeta, with Scer\GAL4pnr-MD237
chordotonal organ
dorsal vessel wall cell
egg chamber
egg chamber & cell
egg chamber & mitotic cell cycle
embryonic/larval ganglionic tracheal branch
embryonic/larval salivary gland | embryonic stage, with Scer\GAL4F4
embryonic/larval tracheal dorsal trunk (with Df(3L)vin3)
embryonic/larval tracheal transverse connective (with Df(3L)vin3)
embryonic epidermis
embryonic epidermis (with CycA3)
embryonic epidermis (with CycA5)
embryonic epidermis | embryonic cycle 16
embryonic ganglion mother cell
embryonic GW neuron
embryonic pericardial cell
eye
eye, with Scer\GAL4da.G32
eye, with Scer\GAL4ey.PU
eye disc, with Scer\GAL4GMR.PF
eye disc | somatic clone | third instar larval stage
eye disc | third instar larval stage
eye disc morphogenetic furrow
female germline stem cell, with Scer\GAL4VP16.nanos.UTR
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
ganglion mother cell GMC1-1a
ganglion mother cell GMC4-2a
germarium, with Scer\GAL4VP16.nanos.UTR
larval DA1 motor neuron | precursor
larval EL neuron
larval EW neuron
larval glial cell
larval longitudinal connective
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
larval outer optic anlage, with Scer\GAL4c768
larval thoracic perisympathetic organ
larval tracheal system
male germline stem cell, with Scer\GAL4VP16.nanos.UTR
mesonotum, with Scer\GAL4pnr-MD237
metaphase & condensed nuclear chromosome
mitotic cell cycle
mitotic cell cycle, with Scer\GAL4prd.RG1
neuroblast NB7-3
neuron & peripheral nervous system
neuron | embryonic stage
nurse cell fusome
ommatidium, with Scer\GAL4da.G32
pCC neuron
pCC neuron | precursor
presumptive embryonic/larval central nervous system
RP2sib neuron
spermatocyte, with Scer\GAL4VP16.bam
S phase | ectopic
S phase | ectopic, with Scer\GAL4hs.2sev
symmetrical commissure
thoracic neuroblast NB6-4
U neuron
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (27)
Hsap\CCNA2
12 of 14
Yes
Yes
Hsap\CCNA1
11 of 14
No
Yes
Hsap\CCNB1
7 of 14
No
No
1  
Hsap\CCNB2
6 of 14
No
No
1  
Hsap\CCNB3
4 of 14
No
No
Hsap\CCNE2
4 of 14
No
No
1  
Hsap\CCNE1
3 of 14
No
No
1  
Hsap\CCNF
3 of 14
No
Yes
Hsap\CCNG1
3 of 14
No
No
Hsap\CCNG2
3 of 14
No
No
1  
Hsap\CCNI2
3 of 14
No
Yes
Hsap\CCNJ
3 of 14
No
No
1  
Hsap\CCNJL
3 of 14
No
No
Hsap\CCND1
2 of 14
No
No
Hsap\CCND3
2 of 14
No
No
1  
Hsap\CCNI
2 of 14
No
No
1  
Hsap\CCNO
2 of 14
No
No
Hsap\CCNP
2 of 14
No
No
Hsap\CCNC
1 of 14
No
No
1  
Hsap\CCND2
1 of 14
No
No
1  
Hsap\CCNH
1 of 14
No
No
1  
Hsap\CCNK
1 of 14
No
No
Hsap\CCNL1
1 of 14
No
No
1  
Hsap\CCNL2
1 of 14
No
No
Hsap\CCNQ
1 of 14
No
No
Hsap\CCNT1
1 of 14
No
No
Hsap\CCNT2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Ccna2
12 of 14
Yes
Yes
Rnor\Ccna1
11 of 14
No
Yes
Rnor\Ccnb1
6 of 14
No
No
Rnor\Ccnb3
4 of 14
No
No
Rnor\Ccne2
4 of 14
No
No
Rnor\Ccne1
3 of 14
No
No
Rnor\Ccnf
3 of 14
No
Yes
Rnor\Ccng1
3 of 14
No
No
Rnor\Ccng2
3 of 14
No
No
Rnor\Ccnjl
3 of 14
No
No
Rnor\Ccnj
3 of 14
No
No
Rnor\Ccnd1
2 of 14
No
No
Rnor\Ccnd3
2 of 14
No
No
Rnor\Ccni
2 of 14
No
No
Rnor\Ccno
2 of 14
No
No
Rnor\Ccnb2
1 of 14
No
Yes
Rnor\Ccnd2
1 of 14
No
No
Rnor\LOC100364016
1 of 14
No
Yes
Mus musculus (laboratory mouse) (17)
Mmus\Ccna1
11 of 14
Yes
Yes
Mmus\Ccna2
11 of 14
Yes
Yes
Mmus\Ccnb1
7 of 14
No
No
Mmus\Ccnb2
6 of 14
No
No
Mmus\Ccnb3
4 of 14
No
No
Mmus\Ccne2
4 of 14
No
No
Mmus\Ccne1
3 of 14
No
No
Mmus\Ccnf
3 of 14
No
Yes
Mmus\Ccng1
3 of 14
No
No
Mmus\Ccng2
3 of 14
No
No
Mmus\Ccnjl
3 of 14
No
No
Mmus\Ccnj
3 of 14
No
No
Mmus\Ccnd1
2 of 14
No
No
1  
Mmus\Ccnd3
2 of 14
No
No
Mmus\Ccni
2 of 14
No
No
Mmus\Ccno
2 of 14
No
No
Mmus\Ccnd2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (40)
Xtro\ccna2
7 of 13
Yes
Yes
Xtro\ap3b2
6 of 13
No
No
Xtro\ccna1
6 of 13
No
Yes
Xtro\rsad1
5 of 13
No
Yes
Xtro\ccnb1
4 of 13
No
No
Xtro\ccnb2
4 of 13
No
No
Xtro\LOC394448
4 of 13
No
No
Xtro\ccnb1.2
3 of 13
No
No
Xtro\ccnb3
3 of 13
No
No
Xtro\ccne1
2 of 13
No
No
Xtro\ccne2
2 of 13
No
No
Xtro\ccnf
2 of 13
No
Yes
Xtro\ripply2.1
2 of 13
No
No
Xtro\anxa1.2
1 of 13
No
Yes
Xtro\anxa13
1 of 13
No
No
Xtro\arl14ep
1 of 13
No
No
Xtro\ccnc
1 of 13
No
No
Xtro\ccndx
1 of 13
No
No
Xtro\ccng1
1 of 13
No
No
Xtro\ccng2
1 of 13
No
No
Xtro\ccnh
1 of 13
No
No
Xtro\ccni2
1 of 13
No
Yes
Xtro\ccni
1 of 13
No
No
Xtro\ccnj
1 of 13
No
No
Xtro\ccnl2
1 of 13
No
No
Xtro\elk3
1 of 13
No
Yes
Xtro\foxred1
1 of 13
No
No
Xtro\frem1l
1 of 13
No
Yes
Xtro\LOC100487999
1 of 13
No
No
Xtro\LOC100493210
1 of 13
No
Yes
Xtro\LOC101730848
1 of 13
No
No
Xtro\LOC105946681
1 of 13
No
No
Xtro\LOC105948063
1 of 13
No
Yes
Xtro\LOC116406785
1 of 13
No
No
Xtro\rbpms2
1 of 13
No
No
Xtro\rnf151
1 of 13
No
No
Xtro\tm4sf4
1 of 13
No
Yes
Xtro\XB940382
1 of 13
No
Yes
Xtro\XB997834
1 of 13
No
No
Xtro\zmpste24
1 of 13
No
No
Danio rerio (Zebrafish) (21)
Drer\ccna2
12 of 14
Yes
Yes
Drer\ccna1
11 of 14
No
Yes
Drer\ccnb1
7 of 14
No
No
Drer\ccnb2
6 of 14
No
No
Drer\ccnb3
4 of 14
No
No
Drer\ccne2
3 of 14
No
No
Drer\ccng1
3 of 14
No
No
Drer\ccng2
3 of 14
No
No
Drer\ccni2
3 of 14
No
Yes
Drer\ccnj
3 of 14
No
No
Drer\ccnd1
2 of 14
No
No
Drer\ccndx
2 of 14
No
No
Drer\ccne1
2 of 14
No
No
Drer\ccnf
2 of 14
No
Yes
Drer\ccni
2 of 14
No
No
Drer\ccnjl
2 of 14
No
No
Drer\ccnp
2 of 14
No
No
Drer\ccnd2a
1 of 14
No
No
Drer\ccnd2b
1 of 14
No
No
Drer\ccnd3
1 of 14
No
No
Drer\ccno
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (23)
Cele\cya-1
9 of 14
Yes
Yes
Cele\cyb-1
7 of 14
No
No
Cele\cyb-2.1
7 of 14
No
No
Cele\cyb-2.2
7 of 14
No
No
Cele\cya-2
3 of 14
No
Yes
Cele\cyb-3
3 of 14
No
No
Cele\F08F1.9
3 of 14
No
Yes
Cele\T24A6.1
3 of 14
No
Yes
Cele\cye-1
2 of 14
No
No
Cele\T07F10.5
2 of 14
No
Yes
Cele\T12C9.7
2 of 14
No
Yes
Cele\W05G11.2
2 of 14
No
Yes
Cele\ZK678.3
2 of 14
No
Yes
Cele\C02B8.1
1 of 14
No
Yes
Cele\C03B8.2
1 of 14
No
Yes
Cele\C04C3.4
1 of 14
No
Yes
Cele\ccnk-1
1 of 14
No
No
Cele\cic-1
1 of 14
No
No
Cele\cit-1.1
1 of 14
No
No
Cele\cit-1.2
1 of 14
No
No
Cele\cyd-1
1 of 14
No
No
Cele\cyl-1
1 of 14
No
No
Cele\R02F2.1
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (15)
Agam\AgaP_AGAP012413
12 of 12
Yes
Yes
Agam\AgaP_AGAP004962
5 of 12
No
No
Agam\AgaP_AGAP004963
5 of 12
No
No
Agam\AgaP_AGAP002478
4 of 12
No
No
Agam\AgaP_AGAP002532
3 of 12
No
No
Agam\AgaP_AGAP001730
2 of 12
No
No
Agam\AgaP_AGAP008191
2 of 12
No
No
Agam\AgaP_AGAP001677
1 of 12
No
No
Agam\AgaP_AGAP005056
1 of 12
No
No
Agam\AgaP_AGAP006678
1 of 12
No
No
Agam\AgaP_AGAP008002
1 of 12
No
No
Agam\AgaP_AGAP008417
1 of 12
No
No
Agam\AgaP_AGAP012299
1 of 12
No
No
Agam\AgaP_AGAP012763
1 of 12
No
No
Agam\CCNC_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (42)
Atha\CYCA2;3
11 of 13
Yes
Yes
Atha\CYCA2;4
11 of 13
Yes
Yes
Atha\CYC3B
10 of 13
No
Yes
Atha\CYCA1;1
10 of 13
No
Yes
Atha\CYCA1;2
10 of 13
No
Yes
Atha\CYCA2;1
10 of 13
No
Yes
Atha\CYCA3;1
10 of 13
No
Yes
Atha\CYCA3;2
10 of 13
No
Yes
Atha\CYCA3;3
10 of 13
No
Yes
Atha\CYCA3;4
10 of 13
No
Yes
Atha\CYC1BAT
7 of 13
No
No
Atha\CYCB1;1
7 of 13
No
No
Atha\CYCB1;3
7 of 13
No
No
Atha\CYCB2;3
7 of 13
No
No
Atha\CYCB2;4
7 of 13
No
No
Atha\CYCB3;1
7 of 13
No
No
Atha\AT1G20590
6 of 13
No
Yes
Atha\CYCB1;4
6 of 13
No
No
Atha\CYCB1;5
6 of 13
No
No
Atha\CYCB2;1
6 of 13
No
No
Atha\CYCB2;2
6 of 13
No
No
Atha\SDS
3 of 13
No
Yes
Atha\CYCD1;1
2 of 13
No
No
Atha\CYCD2;1
2 of 13
No
No
Atha\CYCD3;1
2 of 13
No
No
Atha\CYCD3;2
2 of 13
No
No
Atha\CYCD3;3
2 of 13
No
No
Atha\CYCD4;1
2 of 13
No
No
Atha\CYCD4;2
2 of 13
No
No
Atha\CYCD5;1
2 of 13
No
No
Atha\CYCD6;1
2 of 13
No
No
Atha\CYCD7;1
2 of 13
No
No
Atha\AT2G01310
1 of 13
No
Yes
Atha\AT5G45190
1 of 13
No
No
Atha\AT5G48630
1 of 13
No
No
Atha\AT5G48640
1 of 13
No
No
Atha\CYCJ18
1 of 13
No
Yes
Atha\CYCT1;1
1 of 13
No
No
Atha\CYCT1;2
1 of 13
No
No
Atha\CYCT1;3
1 of 13
No
No
Atha\CYCT1;4
1 of 13
No
No
Atha\RCY1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\CLB1
7 of 13
Yes
No
Scer\CLB2
7 of 13
Yes
No
Scer\CLB5
7 of 13
Yes
Yes
Scer\CLB3
6 of 13
No
No
Scer\CLB4
6 of 13
No
No
Scer\CLB6
6 of 13
No
No
Scer\CLN1
4 of 13
No
Yes
Scer\CLN2
4 of 13
No
Yes
Scer\CLN3
3 of 13
No
Yes
Scer\CTK2
1 of 13
No
No
Scer\SSN8
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\cdc13
7 of 12
Yes
No
Spom\cig2
7 of 12
Yes
No
Spom\cig1
6 of 12
No
No
Spom\rem1
4 of 12
No
Yes
Spom\puc1
3 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CycA. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (12)
CycB
8 of 13
CycB3
6 of 13
CycE
5 of 13
CycJ
4 of 13
CycD
3 of 13
CycG
2 of 13
CG16903
1 of 13
CycC
1 of 13
CycH
1 of 13
CycK
1 of 13
CycT
1 of 13
koko
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Allele
    Disease
    Interaction
    References
    CycA03946
    exacerbates  tuberous sclerosis
    modeled by Tsc1UAS.cTa, gigUAS.cTa
    (Tapon et al., 2001)
    CycAUAS.cWa
    exacerbates  tauopathy
    modeled by dapUAS.cdNa, Hsap\MAPTR406W.UAS
    (Khurana et al., 2006)
    CycAJF02472
    exacerbates  cancer
    modeled by RbfHMS03004
    (Parkhitko et al., 2021)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CCNA2; cyclin A2
    12 of 14
    123835
        CCNA1; cyclin A1
        11 of 14
        604036
            CCNB1; cyclin B1
            7 of 14
            123836
                 
                CCNB2; cyclin B2
                6 of 14
                602755
                     
                    CCNB3; cyclin B3
                    4 of 14
                    300456
                        CCNE2; cyclin E2
                        4 of 14
                        603775
                             
                            CCNE1; cyclin E1
                            3 of 14
                            123837
                                 
                                CCNF; cyclin F
                                3 of 14
                                600227
                                  CCNG1; cyclin G1
                                  3 of 14
                                  601578
                                      CCNG2; cyclin G2
                                      3 of 14
                                      603203
                                           
                                          CCNI2; cyclin I family member 2
                                          3 of 14
                                          620419
                                              CCNJ; cyclin J
                                              3 of 14
                                              620395
                                                   
                                                  CCNJL; cyclin J like
                                                  3 of 14
                                                      Functional Complementation Data
                                                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                      Interactions
                                                      Summary of Physical Interactions
                                                      esyN Network Diagram
                                                      Show neighbor-neighbor interactions:
                                                      Show/hide secondary interactors 
                                                      (data from AllianceMine provided by esyN)
                                                      Select Layout:
                                                      Legend:
                                                      Protein
                                                      RNA
                                                      Selected Interactor(s)
                                                      Other Interaction Browsers
                                                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                      Please see the Physical Interaction reports below for full details
                                                      protein-protein
                                                      Physical Interaction
                                                      Assay
                                                      References
                                                      CycA - Cdk1
                                                      experimental knowledge based, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, two hybrid
                                                      (Darnat et al., 2022, Ayeni et al., 2014, Guruharsha et al., 2011, Gawlinski et al., 2007, Avedisov et al., 2000, Lane et al., 1996, Sauer et al., 1996, Knoblich et al., 1994)
                                                      CycA - Cdk2
                                                      two hybrid
                                                      (Avedisov et al., 2000, Sauer et al., 1996)
                                                      CycA - Cks30A
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - Cks85A
                                                      anti tag coimmunoprecipitation, western blot, experimental knowledge based
                                                      (Guruharsha et al., 2011, Swan et al., 2005)
                                                      CycA - CycB
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - CycB3
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - Gcn5
                                                      anti tag coimmunoprecipitation, anti tag western blot
                                                      (Liu et al., 2017)
                                                      CycA - Hsp23
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - Hsp26
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - Myb
                                                      anti tag coimmunoprecipitation, western blot
                                                      (Rotelli et al., 2019)
                                                      CycA - Skp2
                                                      anti tag coimmunoprecipitation, western blot, pull down, anti tag western blot
                                                      (Vasavan et al., 2024)
                                                      CycA - Synd
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - Z600
                                                      anti bait coimmunoprecipitation, western blot, pull down, autoradiography, surface plasmon resonance
                                                      (Gawlinski et al., 2007)
                                                      CycA - bam
                                                      anti tag coimmunoprecipitation, anti tag western blot, western blot
                                                      (Ji et al., 2017)
                                                      CycA - cort
                                                      pull down, anti tag western blot
                                                      (Whitfield et al., 2013)
                                                      CycA - dsh
                                                      anti tag coimmunoprecipitation, anti tag western blot
                                                      (Darnat et al., 2022)
                                                      CycA - fz
                                                      proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, anti tag western blot
                                                      (Darnat et al., 2022)
                                                      CycA - fzr
                                                      anti tag coimmunoprecipitation, peptide massfingerprinting
                                                      (Meghini et al., 2016)
                                                      CycA - fzy
                                                      pull down, anti tag western blot, anti tag coimmunoprecipitation, experimental knowledge based
                                                      (Whitfield et al., 2013, Guruharsha et al., 2011, Chen et al., 2009)
                                                      CycA - otu
                                                      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot
                                                      (Ji et al., 2017)
                                                      CycA - r-l
                                                      experimental knowledge based
                                                      (Guruharsha et al., 2011)
                                                      CycA - rux
                                                      anti tag coimmunoprecipitation, anti tag western blot, two hybrid, anti bait coimmunoprecipitation, western blot, experimental knowledge based
                                                      (Guruharsha et al., 2011, Avedisov et al., 2000, Foley et al., 1999)
                                                      CycA - tara
                                                      anti tag coimmunoprecipitation, western blot
                                                      (Afonso et al., 2015)
                                                      RNA-protein
                                                      Physical Interaction
                                                      Assay
                                                      References
                                                      CycA - Dcr-2
                                                      anti tag coimmunoprecipitation, quantitative reverse transcription pcr
                                                      (Nadimpalli et al., 2022)
                                                      CycA - Marf1
                                                      anti tag coimmunoprecipitation, quantitative reverse transcription pcr
                                                      (Zhu et al., 2018)
                                                      CycA - aub
                                                      iclip, partial RNA sequence identification
                                                      (Barckmann et al., 2015)
                                                      Summary of Genetic Interactions
                                                      esyN Network Diagram
                                                      Show/hide secondary interactors 
                                                      (data from AllianceMine provided by esyN)
                                                      esyN Network Key:
                                                      Suppression
                                                      Enhancement
                                                      Other Interaction Browsers
                                                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                      Please look at the allele data for full details of the genetic interactions
                                                      Starting gene(s)
                                                      Interaction type
                                                      Interacting gene(s)
                                                      Reference
                                                      CycA
                                                      suppressible
                                                      bam
                                                      (Lilly et al., 2000)
                                                      CycA
                                                      enhanceable
                                                      Cdk1
                                                      (Parry and O'Farrell, 2001)
                                                      CycA
                                                      suppressible
                                                      CycB
                                                      (Dienemann and Sprenger, 2004, Knoblich and Lehner, 1993)
                                                      CycA
                                                      enhanceable
                                                      CycB
                                                      (Han and Bodmer, 2003)
                                                      CycA
                                                      suppressible
                                                      CycE
                                                      (Reber et al., 2006)
                                                      Cdk1|CycA
                                                      suppressible
                                                      E2f1
                                                      (Hayashi and Yamaguchi, 1999)
                                                      CycA
                                                      suppressible
                                                      fzr
                                                      (Martins et al., 2017)
                                                      CycA
                                                      enhanceable
                                                      pim
                                                      (Leismann and Lehner, 2003)
                                                      CycA
                                                      enhanceable
                                                      Rca1
                                                      (Grosskortenhaus and Sprenger, 2002)
                                                      CycA|Cdk1
                                                      suppressible
                                                      rux
                                                      (Foley et al., 1999)
                                                      CycA
                                                      enhanceable
                                                      rux
                                                      (Foley and Sprenger, 2001)
                                                      CycA
                                                      suppressible
                                                      rux
                                                      (Foley and Sprenger, 2001)
                                                      CycA
                                                      suppressible
                                                      rux|Cdk1
                                                      (Foley et al., 1999)
                                                      Starting gene(s)
                                                      Interaction type
                                                      Interacting gene(s)
                                                      Reference
                                                      arm
                                                      enhanceable
                                                      CycA
                                                      (Greaves et al., 1999)
                                                      babo
                                                      suppressible
                                                      CycA
                                                      (Zhu et al., 2008)
                                                      cato
                                                      suppressible
                                                      CycA
                                                      (zur Lage and Jarman, 2010)
                                                      Cdk1
                                                      suppressible
                                                      CycA
                                                      (Hayashi and Yamaguchi, 1999)
                                                      Cks30A
                                                      suppressible
                                                      CycA
                                                      (Swan et al., 2005)
                                                      CycB
                                                      suppressible
                                                      CycA
                                                      (Ji et al., 2002)
                                                      CycE
                                                      enhanceable
                                                      CycA
                                                      (Secombe et al., 1998)
                                                      dally
                                                      suppressible
                                                      CycA
                                                      (Nakato et al., 2002)
                                                      dome
                                                      suppressible
                                                      CycA
                                                      (Recasens-Alvarez et al., 2017)
                                                      E2f1
                                                      suppressible
                                                      CycA
                                                      (Ji et al., 2012)
                                                      eff
                                                      suppressible
                                                      CycA
                                                      (Lilly et al., 2000)
                                                      eff
                                                      enhanceable
                                                      CycA
                                                      (Chen et al., 2009)
                                                      fzr
                                                      suppressible
                                                      CycA
                                                      (Reber et al., 2006)
                                                      mei-41
                                                      suppressible
                                                      CycB|CycA
                                                      (Sibon et al., 1999)
                                                      mei-41
                                                      suppressible
                                                      CycA
                                                      (Sibon et al., 1999)
                                                      Myt1
                                                      suppressible
                                                      CycA
                                                      (Willms et al., 2020, Varadarajan et al., 2016)
                                                      numb
                                                      enhanceable
                                                      CycA
                                                      (Wai et al., 1999)
                                                      png
                                                      enhanceable
                                                      CycA
                                                      (Lee et al., 2001)
                                                      PolA1|mei-41
                                                      suppressible
                                                      CycA
                                                      (LaRocque et al., 2007)
                                                      Ras85D
                                                      suppressible
                                                      CycA
                                                      (Zhang et al., 2024)
                                                      Rca1
                                                      suppressible
                                                      CycA
                                                      (Grosskortenhaus and Sprenger, 2002)
                                                      Rca1
                                                      enhanceable
                                                      CycA
                                                      (Grosskortenhaus and Sprenger, 2002)
                                                      Ret
                                                      enhanceable
                                                      CycA
                                                      (Read et al., 2005)
                                                      rux
                                                      suppressible
                                                      CycA
                                                      (Dong et al., 1997, Gonczy et al., 1994, Thomas et al., 1994)
                                                      shtd
                                                      suppressible
                                                      CycA
                                                      (Tanaka-Matakatsu et al., 2007)
                                                      tara
                                                      enhanceable
                                                      CycA
                                                      (Afonso et al., 2015)
                                                      twin
                                                      suppressible
                                                      CycA
                                                      (Morris et al., 2005)
                                                      upd1
                                                      enhanceable
                                                      CycA
                                                      (Mukherjee et al., 2006)
                                                      wg
                                                      suppressible
                                                      CycA
                                                      (Ewen-Campen and Perrimon, 2024, McClure and Schubiger, 2008)
                                                      wts
                                                      suppressible
                                                      CycA
                                                      (Tao et al., 1999)
                                                      External Data
                                                      Subunit Structure (UniProtKB)
                                                      Component of the Frs-CycA-Cdk1 complex composed of CycA, Cdk1 and Z600 (PubMed:17431409). Interacts (via C-terminus) with Z600 (PubMed:17431409). Interacts with otu and (via C-terminus) with bam; the interaction stabilizes CycA by negatively regulating its ubiquitination (PubMed:28484036).
                                                      (UniProt, P14785 )
                                                      Linkouts
                                                      BioGRID - A database of protein and genetic interactions.
                                                      DroID - A comprehensive database of gene and protein interactions.
                                                      MIST (genetic) - An integrated Molecular Interaction Database
                                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                                      Pathways
                                                      Class of Gene
                                                      Genomic Location and Detailed Mapping Data
                                                      Chromosome (arm)
                                                      3L
                                                      Recombination map
                                                      3-37
                                                      Cytogenetic map
                                                      68E1-68E1
                                                      Sequence location
                                                      FlyBase Computed Cytological Location
                                                      Cytogenetic map
                                                      Evidence for location
                                                      68E1-68E1
                                                      Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
                                                      Experimentally Determined Cytological Location
                                                      Cytogenetic map
                                                      Notes
                                                      References
                                                      68E1-68E2
                                                      (determined by in situ hybridisation)
                                                      (Spradling et al., 1999)
                                                      68E-68E
                                                      (determined by in situ hybridisation)
                                                      (Szeged Stock Center, 1998-, Deak et al., 1997, Salzberg et al., 1997, Whitfield et al., 1990, Whitfield et al., 1989)
                                                      68E1-68E2
                                                      68E1--3
                                                      (BDGP Project Members, 1994-1999)
                                                      68D-68E
                                                      (determined by in situ hybridisation)
                                                      (Berg and Spradling, 1991, Lehner and O'Farrell, 1989, Cooley et al., 1988)
                                                      Experimentally Determined Recombination Data
                                                      Location

                                                      3-37

                                                      (FlyBase, 2016, Dong et al., 1997)

                                                      3-30.3

                                                      (Comeron et al., 2012)

                                                      3-37.6--39

                                                      (Salzberg et al., 1994)
                                                      Left of (cM)
                                                      Right of (cM)
                                                      Notes
                                                      Stocks and Reagents
                                                      Stocks (31)
                                                      Genomic Clones (22)
                                                      cDNA Clones (341)
                                                       

                                                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                      cDNA clones, fully sequenced
                                                      BDGP DGC clones
                                                      Other clones
                                                      Drosophila Genomics Resource Center cDNA clones

                                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                      cDNA Clones, End Sequenced (ESTs)
                                                      BDGP DGC clones
                                                      Other clones
                                                      RNAi and Array Information
                                                      Linkouts
                                                      DRSC - Results frm RNAi screens
                                                      Antibody Information
                                                      Laboratory Generated Antibodies
                                                       

                                                      polyclonal

                                                      (Whitfield et al., 1990, Lehner and O'Farrell, 1989)
                                                      Commercially Available Antibodies
                                                       
                                                      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                                                      Cell Line Information
                                                      Publicly Available Cell Lines
                                                       
                                                        Other Stable Cell Lines
                                                         
                                                          Other Comments

                                                          The CycA protein inhibits the premature degradation of mitotic cyclins and stg protein by negatively regulating the rap protein.

                                                          (Reber et al., 2006)

                                                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                                                          (Boutros et al., 2004)

                                                          CycA is required for entry into mitosis.

                                                          (Jacobs et al., 2001)

                                                          The presence of the N terminal region is not required for CycAs function in mitotic entry.

                                                          (Jacobs et al., 2001)

                                                          CycA degradation facilitates chromosome disjunction.

                                                          (Parry and O'Farrell, 2001)

                                                          Two EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.

                                                          (Hummel et al., 1999)

                                                          Candidate gene for tibia length quantitative trait locus.

                                                          (Macdonald and Goldstein, 1999)

                                                          Candidate gene for quantitative trait (QTL) locus determining bristle number.

                                                          (Nuzhdin et al., 1999)

                                                          CycA regulates the nuclear changes while CycB regulates cytoskeletal changes in syncytial preblastoderm embryos.

                                                          (Stiffler et al., 1999)

                                                          A balance of CycA and CycB proteins seems necessary for proper coordination during the embryonic cycles.

                                                          (Stiffler et al., 1999)

                                                          numb functions downstream of cell division genes (CycA, Rca1 and stg) and progression through the cell cycle is required for asymmetric localisation of numb and thus N mediated specification of the sib fate in the RP2/sib division.

                                                          (Wai et al., 1999)

                                                          The loss of CycA, Rca1 or stg leads to a block in the division of GMC-1, however this GMC-1 adopts a RP2 identity.

                                                          (Wai et al., 1999)

                                                          Double and triple mutant analyses show that CycB3, CycB and CycA cooperate during mitosis.

                                                          (Jacobs et al., 1998)

                                                          Rca1 positively regulates CycA by modulating CycA protein levels.

                                                          (Dong et al., 1997)

                                                          CycA is misexpressed in the PNS of da mutant embryos.

                                                          (Hassan and Vaessin, 1997)

                                                          CycA protein can drive the G1/S transition in embryos, but this function is suppressed by three types of control: destruction of CycA protein, inhibitory phosphorylation of cdc2 and inhibition by rux.

                                                          (Sprenger et al., 1997)

                                                          Ectopic rux converts the mitotic cycle into an endoreplication cycle by down-regulating CycA-associated kinase activity.

                                                          (Thomas et al., 1997)

                                                          Cloning and sequencing of CycA reveals a sequence identical to DRE (DNA replication-related element) in the region of nucleotide positions -71 to -64 with respect to the transcription initiation site. The role of the DRE in promoter activity is studied and results indicate CycA is under the control of the DRE/Dref system.

                                                          (Ohno et al., 1996)

                                                          Heterozygosity for CycA is not sufficient for females to produce viable homozygous kni mutant progeny. Double heterozygotes for CycA and CycB increase the efficiency for kni mutant rescue suggesting the cyclins interact synergistically.

                                                          (Ruden and Jäckle, 1995)

                                                          Observations in CycA mutants implicate G2 cyclins in reinitiation of DNA replication during the G2 phase of the mitotic cell cycle.

                                                          (Sauer et al., 1995)

                                                          Comparison of the fzy mutant phenotype with the phenotype resulting from expression of N-terminal truncated CycA, CycB or CycB3 suggests that fzy is not required for mitotic cyclin degradation alone, because fzy mutations, but not truncated cyclins, block chromosome separation.

                                                          (Sigrist et al., 1995)

                                                          rux acts genetically to negatively regulate CycA.

                                                          (Thomas et al., 1995)

                                                          During development, changing levels of cell cycle regulators alters the rate limiting step and the mechanism governing progress of the cell cycle.

                                                          (Edgar et al., 1994)

                                                          Mutation in CycA affects cell division in the neuronal lineage.

                                                          (Salzberg et al., 1994)

                                                          CycA is required for PNS development in the embryo.

                                                          (Salzberg et al., 1994)

                                                          CycA transcripts injected into the syncytial blastoderm do not become incorporated to the pole cells, as CycB transcripts do.

                                                          (Dalby and Glover, 1993)

                                                          The CycA product has a mitotic function and acts synergistically with CycB during the G2-M transition.

                                                          (Knoblich and Lehner, 1993)

                                                          As part of an investigation into the effects of 37oC heat shock on G2-phase cycle 14 embryos, the degradation of cyclin A and cyclin B in the resulting synchronised mitotic domains was shown to be delayed.

                                                          (Maldonado-Codina et al., 1993)

                                                          CycA gene product is not required for the continued rounds of DNA replication in the ventral cord or in endoreplicating tissues during embryonic development.

                                                          (Smith et al., 1993)

                                                          A functional CycA gene is required for continued cell division after exhaustion of maternally provided cyclin A.

                                                          (Lindsley and Zimm, 1992)

                                                          Maternal message uniformly distributed in newly laid egg, but becomes more concentrated in the cortex prior to peripheral nuclear migration. At the time of cellularization of the blastoderm, zygotic message is produced. Cyclin A accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded during metaphase. Message confined to dividing tissues in brain and imaginal discs in larvae.

                                                          (Lindsley and Zimm, 1992)

                                                          CycA and CycB are coexpressed in all proliferating cells throughout development.

                                                          (Lehner and O'Farrell, 1990)

                                                          CycA has a role in the G2 to M transition, independent of spindle formation.

                                                          (Whitfield et al., 1990)

                                                          CycA is required for cell cycle progression.

                                                          (Lehner and O'Farrell, 1989)
                                                          Relationship to Other Genes
                                                          Source for database merge of

                                                          Source for merge of: CycA anon-WO0140519.128

                                                          (FlyBase, 1996-)
                                                          Additional comments

                                                          Source for merge of CycA anon-WO0140519.128 was sequence comparison ( date:051113 ).

                                                          (FlyBase, 1996-)
                                                          Nomenclature History
                                                          Source for database identify of

                                                          Source for identity of: CycA CG5940

                                                          (Zhang, 1999.11)
                                                          Nomenclature comments
                                                          Etymology
                                                          Synonyms and Secondary IDs (35)
                                                          Reported As
                                                          Symbol Synonym
                                                          0033/02
                                                          (Deak et al., 1997)
                                                          0040/24
                                                          (Deak et al., 1997)
                                                          0046/23
                                                          (Deak et al., 1997)
                                                          0104/07
                                                          (Deak et al., 1997)
                                                          0245/34
                                                          (Deak et al., 1997)
                                                          0521/06
                                                          (Deak et al., 1997)
                                                          0545/13
                                                          (Deak et al., 1997)
                                                          1329/16
                                                          (Deak et al., 1997)
                                                          1449/05
                                                          (Deak et al., 1997)
                                                          CG5940
                                                          (Ibaraki et al., 2021, Neuert et al., 2017, Hosono et al., 2015, Zeng et al., 2015, Fukuoh et al., 2014, Cui et al., 2013, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Haussmann et al., 2008, Ni et al., 2008, Wheeler et al., 2004)
                                                          CLD3
                                                          (Erhardt et al., 2008)
                                                          CYCA
                                                          (Dattoli et al., 2020, Iovino et al., 2013, Erhardt et al., 2008)
                                                          CYCLIN A
                                                          (Carty and Dunleavy, 2020)
                                                          Cyc A
                                                          (Zurita and Murillo-Maldonado, 2020, Dequéant et al., 2015, McCleland and O'Farrell, 2008, Wheeler et al., 2004)
                                                          CycA
                                                          (Bourouh et al., 2024, Goins et al., 2024, Isaacson et al., 2024, Matthew et al., 2024, Trujillo et al., 2024, Vasavan et al., 2024, Vesala et al., 2024, Avellino et al., 2023, Neophytou et al., 2023, Olivares et al., 2023, Riemondy et al., 2023, Zhang et al., 2023, Almeida Machado Costa et al., 2022, Darnat et al., 2022, Diegmiller et al., 2022, Eickelberg et al., 2022, Nadimpalli et al., 2022, Bailey et al., 2021, Ferguson et al., 2021, Ibaraki et al., 2021, Parkhitko et al., 2021, Zhang et al., 2021, Cho et al., 2020, Hur et al., 2020, Kordyukova et al., 2020, Mishra et al., 2020, Shi et al., 2020, Vaccaro et al., 2020, Willms et al., 2020, Zhao et al., 2020, Archambault, 2019.12.8, Blake-Hedges and Megraw, 2019, Greenblatt et al., 2019, Harding and White, 2019, Kondo and Hayashi, 2019, Liao et al., 2019, Parker et al., 2019, Rivera et al., 2019, Rotelli et al., 2019, Eusebio et al., 2018, Flora et al., 2018, García Del Arco et al., 2018, Gene Disruption Project members, 2018-, Hakes et al., 2018, Hao et al., 2018, Otsuki and Brand, 2018, Swevers et al., 2018, Wu et al., 2018, Hara et al., 2017, Heseding et al., 2017, Housden et al., 2017, Ji et al., 2017, Liu et al., 2017, Martins et al., 2017, Neto et al., 2017, Neuert et al., 2017, Recasens-Alvarez et al., 2017, Siddall and Hime, 2017, Tomita et al., 2017, Transgenic RNAi Project members, 2017-, Weber and Mlodzik, 2017, Bourouh et al., 2016, Chandra et al., 2016, Gomez et al., 2016, Meghini et al., 2016, Qi and Calvi, 2016, Ricolo et al., 2016, Varadarajan et al., 2016, Afonso et al., 2015, Afonso et al., 2015, Bergman et al., 2015, Di Cara et al., 2015, Doggett et al., 2015, Gene Disruption Project members, 2015-, Matsuda et al., 2015, Wang and Baker, 2015, Ashwal-Fluss et al., 2014, Butí et al., 2014, Eliazer et al., 2014, Frost et al., 2014, Günesdogan et al., 2014, Hassel et al., 2014, Parsons et al., 2014, Singh et al., 2014, Bandura et al., 2013, Bonke et al., 2013, Chang et al., 2013, Kondo and Hayashi, 2013, Lehner, 2013.1.1, Lu et al., 2013, Mishra et al., 2013, Neumüller et al., 2013, Noatynska et al., 2013, Organista and De Celis, 2013, Saunders et al., 2013, Schertel et al., 2013, Yin et al., 2013, Zhou and Luo, 2013, Farrell et al., 2012, Ito et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ruggiero et al., 2012, Sallé et al., 2012, Tokusumi et al., 2012, van der Harst et al., 2012, Xu et al., 2012, Xu et al., 2012, Yuan et al., 2012, Bangi et al., 2011, Chen et al., 2011, Gilbert et al., 2011, Lindquist et al., 2011, Noyes et al., 2011, Poulton et al., 2011, Richter et al., 2011, Beam and Moberg, 2010, Beck et al., 2010, Biehs et al., 2010, Fox et al., 2010, Li et al., 2010, Monk et al., 2010, Swaminathan et al., 2010, Tastan et al., 2010, zur Lage and Jarman, 2010, Althoff et al., 2009, McCleland et al., 2009, Peng and Karpen, 2009, Shyu et al., 2009, Southall and Brand, 2009, Bakal et al., 2008, Benoit et al., 2008, Bowman et al., 2008, Caussinus et al., 2008, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Lee et al., 2008, O'Farrell and Kylsten, 2008, Sato et al., 2008, Shimizu et al., 2008, Ambrus et al., 2007, Beltran et al., 2007, Escudero and Freeman, 2007, Franklin-Dumont et al., 2007, Gawlinski et al., 2007, Gawlinski et al., 2007, Griffiths et al., 2007, Großhans et al., 2007, Johnson et al., 2007, Kankel et al., 2007, Kugler and Nagel, 2007, LaRocque et al., 2007, LaRocque et al., 2007, Lecuyer et al., 2007, Link et al., 2007, Magalhaes et al., 2007, Minakhina et al., 2007, Pfleger et al., 2007, Ramachandran et al., 2007, Sandmann et al., 2007, Sun and Deng, 2007, Swan and Schupbach, 2007, Tanaka-Matakatsu et al., 2007, Tanaka-Matakatsu et al., 2007, Friedman and Perrimon, 2006, Jones et al., 2006, Jordan et al., 2006, Khurana et al., 2006, Morris et al., 2006, Mukherjee et al., 2006, Sugimura and Lilly, 2006, Vrailas and Moses, 2006, Zielke et al., 2006, Baonza and Freeman, 2005, Greene et al., 2005, Stanyon et al., 2004, Heriche et al., 2003, Leismann and Lehner, 2003, Huang and Raff, 2002)
                                                          Cyclin A
                                                          (Hara et al., 2018, Kohzaki et al., 2018, Zhu et al., 2018)
                                                          CyclinA
                                                          (Jin et al., 2020)
                                                          DmcycA
                                                          (Horb and Horb, 2010, Zraly et al., 2004)
                                                          S(rux)3B
                                                          (Dong et al., 1997)
                                                          anon-WO0140519.128
                                                          cycA
                                                          (Kim et al., 2021, Keane et al., 2020, Liaw and Chiang, 2019, Ray et al., 2019, Kim et al., 2018, Lefebvre and Lécuyer, 2018, Ji et al., 2017, Jahanshahi et al., 2016, Kotov et al., 2016, Barckmann et al., 2015, Flores et al., 2015, Lu and Fuller, 2015, Kuang et al., 2014, Buster et al., 2013, Sun and Spradling, 2013, Ruggiero et al., 2012, Sun and Spradling, 2012, Zhai et al., 2012, Vincent et al., 2011, Silies and Klämbt, 2010, Chen et al., 2009, Kwon et al., 2009, McClure and Schubiger, 2008, Scaria et al., 2008, Orian et al., 2007, Szabó et al., 2007, McEllin et al., 2006, Chen et al., 2005, Morris et al., 2005, Ayyar et al., 2003, Heriche et al., 2003, Park et al., 2003, Grosskortenhaus and Sprenger, 2002, Ji et al., 2002, Nakato et al., 2002, Akiyama-Oda et al., 2000, Beitel and Krasnow, 2000, Li and Vaessin, 2000, Myster and Duronio, 2000, Greaves et al., 1999, Lear et al., 1999, Truong et al., 1999, Wai et al., 1999, Dong et al., 1997, Salzberg et al., 1997, Sweeney et al., 1997, Hassan and Vassin, 1996, Salzberg and Bellen, 1996, Sauer et al., 1995, Edgar et al., 1994, Salzberg et al., 1994, Thomas et al., 1994, Foe et al., 1993)
                                                          cyclin A
                                                          (Lim et al., 2018)
                                                          dCycA
                                                          (Ito et al., 2012, Ji et al., 2012)
                                                          hari
                                                          l(3)03946
                                                          l(3)183
                                                          (Huang and Fischer-Vize, 1996)
                                                          l(3)68Ea
                                                          l(3)j3C8
                                                          l(3)neo114
                                                          l(3)rsg11
                                                          rsg11
                                                          (Hoogwerf et al., 1988)
                                                          Name Synonyms
                                                          Cyclin A
                                                          (Bhattacharya et al., 2024, Rangone et al., 2024, Bakshi et al., 2023, Tzortzopoulos et al., 2019, Ly et al., 2018, Tomita et al., 2017, Cruz-Becerra et al., 2016, Kotov et al., 2016, Dequéant et al., 2015, Ayeni et al., 2014, Günesdogan et al., 2014, Hassel et al., 2014, Khadilkar et al., 2014, Kuang et al., 2014, Bandura et al., 2013, Lu et al., 2013, Potdar and Sheeba, 2013, Whitfield et al., 2013, Zhou and Luo, 2013, Kanakousaki and Gibson, 2012, Kelsom and Lu, 2012, Ruggiero et al., 2012, Gilbert et al., 2011, O'Keefe et al., 2011, Poulton et al., 2011, Beam and Moberg, 2010, Fox et al., 2010, Li et al., 2010, Monk et al., 2010, Papoulas et al., 2010, Swaminathan et al., 2010, zur Lage and Jarman, 2010, Althoff et al., 2009, Merkle et al., 2009, Morris et al., 2009, Benoit et al., 2008, Caussinus et al., 2008, Narbonne-Reveau et al., 2008, Scaria et al., 2008, Sukhanova and Du, 2008, Zhu et al., 2008, Zielke et al., 2008, Escudero and Freeman, 2007, Franklin-Dumont et al., 2007, Franklin-Dumont et al., 2007, Garcia et al., 2007, Kankel et al., 2007, Kaplow et al., 2007, Kugler and Nagel, 2007, Pesin and Orr-Weaver, 2007, Pfleger et al., 2007, Ramachandran et al., 2007, Rickmyre et al., 2007, Sun and Deng, 2007, Swan and Schupbach, 2007, Takada et al., 2007, Khurana et al., 2006, Pines, 2006, Reber et al., 2006, Silva et al., 2006, Vrailas and Moses, 2006, Vrailas et al., 2006, Zielke et al., 2006, Baonza and Freeman, 2005, Mandal et al., 2005, Thomas, 2005, Loop et al., 2004, Wheeler et al., 2004, Furukawa et al., 2003)
                                                          CyclinA
                                                          (Pinot and Le Borgne, 2024, Gomez et al., 2016, Parsons et al., 2014, Bonke et al., 2013, Iovino et al., 2013, Beck et al., 2010, Bowman et al., 2008, Choksi et al., 2006, Mukherjee et al., 2006, Skeath and Thor, 2003)
                                                          Suppressor of rux 3B
                                                          (Dong et al., 1997)
                                                          cyclin A
                                                          (Funato, 2020, Otsuki and Brand, 2020, Liao et al., 2019, Liu and Grosshans, 2017, Khadilkar et al., 2014, Temme et al., 2014, Cui et al., 2013, Noatynska et al., 2013, Robertson and Keene, 2013, Zhan et al., 2013, Matunis et al., 2012, Andersen et al., 2010, Horb and Horb, 2010, Oliveira et al., 2010, Anderson et al., 2009, Baldinger and Gossen, 2009, Benoit et al., 2009, Chen et al., 2009, Shyu et al., 2009, Vardy et al., 2009, Chia et al., 2008, Erhardt et al., 2008, González et al., 2008, Kotadia et al., 2008, Lee et al., 2008, McCleland and O'Farrell, 2008, McClure and Schubiger, 2008, Shimizu et al., 2008, Brunk et al., 2007, Huang et al., 2007, Huang et al., 2007, Kaplow et al., 2007, Link et al., 2007, Pal et al., 2007, Ringrose and Paro, 2007, Sakaguchi and Steward, 2007, Tadros et al., 2007, Tanaka-Matakatsu et al., 2007, Maurange et al., 2006, Muller and Kassis, 2006, Wodarz and Gonzalez, 2006, Baonza and Freeman, 2005, Chen et al., 2005, Findlay et al., 2005, Frolov et al., 2005, Hyun et al., 2005, Lopes et al., 2005, Wheeler et al., 2004, Douglas and Haddad, 2003, Lee and Orr-Weaver, 2003, Purdy and Su, 2003, Fung et al., 2002, Huang and Raff, 2002, Mihaylov et al., 2002, Nagao and Yanagida, 2002, Nieduszynski et al., 2002, Deng and Lin, 2001, Mahowald, 2001, O'Farrell, 2001, Jaklevic et al., 2000, Lilly et al., 2000, Harper and Elledge, 1998, de Cuevas et al., 1997, Su and O'Farrell, 1997, Sigrist et al., 1995)
                                                          cyclin-A
                                                          (Neto et al., 2017)
                                                          cyclinA
                                                          (Nagy et al., 2012, Vincent et al., 2011, Silies and Klämbt, 2010, Somma et al., 2008)
                                                          rose-gespleten region interval 11
                                                          (Hoogwerf et al., 1988)
                                                          Secondary FlyBase IDs
                                                          • FBgn0010826
                                                          • FBgn0011353
                                                          • FBgn0044754
                                                          Datasets (0)
                                                          Study focus (0)
                                                          Experimental Role
                                                          Project
                                                          Project Type
                                                          Title
                                                          Study result (0)
                                                          Result
                                                          Result Type
                                                          Title
                                                          External Crossreferences and Linkouts ( 78 )
                                                          Sequence Crossreferences
                                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                          Other crossreferences
                                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                          FlyMine - An integrated database for Drosophila genomics
                                                          InterPro - A database of protein families, domains and functional sites
                                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                                          Linkouts
                                                          BioGRID - A database of protein and genetic interactions.
                                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                          DroID - A comprehensive database of gene and protein interactions.
                                                          DRSC - Results frm RNAi screens
                                                          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                          Flygut - An atlas of the Drosophila adult midgut
                                                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                          MIST (genetic) - An integrated Molecular Interaction Database
                                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                          References (662)