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General Information
Symbol
Dmel\CycA
Species
D. melanogaster
Name
Cyclin A
Annotation Symbol
CG5940
Feature Type
FlyBase ID
FBgn0000404
Gene Model Status
Stock Availability
Gene Snapshot
Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. [Date last reviewed: 2019-03-07]
Also Known As
Cyc A, DmcycA, dCycA, rsg11
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:11,826,719..11,833,578 [-]
Recombination map
3-37
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the cyclin family. Cyclin AB subfamily. (P14785)
Summaries
Protein Function (UniProtKB)
Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the Cdk1 and Cdk2 protein kinases to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
(UniProt, P14785)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
CycA: Cyclin A
Encodes cyclin, a molecule involved in the cell cycle; the pattern of transcription reflects this. Maternal message uniformly distributed in newly laid egg, but becomes more concentrated in the cortex prior to peripheral nuclear migration. At the time of cellularization of the blastoderm, zygotic message is produced. Cyclin A accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded during metaphase. A functional cyclin A gene is required for continued cell division after exhaustion of maternally provided cyclin A. Message confined to dividing tissues in brain and imaginal disks in larvae.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\CycA or the JBrowse view of Dmel\CycA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076075
2555
491
FBtr0304650
2916
490
Additional Transcript Data and Comments
Reported size (kB)
2.504 (longest cDNA)
3.0, 2.7 (northern blot)
2.5, 2.3 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075807
56.2
491
5.73
FBpp0293192
56.0
490
5.73
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
CycA protein levels increase in eye discs in response to ectopic expression of Rca1.
External Data
Subunit Structure (UniProtKB)
Component of the Frs-CycA-Cdk1 complex composed of CycA, Cdk1 and Z600. Interacts (via C-terminus) with Z600.
(UniProt, P14785)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycA using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (22 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
non-traceable author statement
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
Biological Process (14 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
cell | subset

Comment: interphase cells

western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The cyclins are normally found in the cytoplasm of interphase cells and become nuclear in prophase cells. CycA protein is abruptly degraded and is not detectable in metaphase or anaphase cells. Cells of embryos heat shocked in G2 phase of cycle 14 show very high levels of the cyclins and cyclin degradation is delayed: heat shock causes a disruption in cell cycle progression.
The highest CycA protein concentration is found in the cytoplasm at interphase. CycA protein associates with chromatin during mitosis. It is not completely degraded at the metaphase-anaphase transition in syncytial embryos.
CycA protein is initially distributed uniformly throughout the syncytial embryo. It becomes concentrated in the cortex in a 30-40 micron deep layer as nuclei migrate to the surface.
CycA protein appears to be concentrated over the region of the condensing chromatin in prophase cells. CycA protein accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded within metaphase.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS010407
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS024534
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS052106
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS052118
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS052119
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS054513
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS132916
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS144905
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS144911
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}CycAS144914
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}CycA03946
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CycA in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 45 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 39 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CycA
Transgenic constructs containing regulatory region of CycA
Deletions and Duplications ( 16 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdominal segment 2 & cardioblast
abdominal segment 3 & cardioblast
abdominal segment 4 & cardioblast
abdominal segment 5 & cardioblast
abdominal segment 6 & cardioblast
abdominal segment 7 & cardioblast
anaphase & condensed nuclear chromosome
egg chamber & cell
egg chamber & mitotic cell cycle
metaphase & condensed nuclear chromosome
neuron & peripheral nervous system
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
11 of 15
No
Yes
3 of 15
No
No
 
3 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (7)
11 of 13
Yes
Yes
11 of 13
Yes
Yes
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (44)
7 of 12
Yes
Yes
6 of 12
No
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
11 of 15
Yes
Yes
8 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (13)
9 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (33)
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
6 of 9
No
Yes
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
Yes
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (9)
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
4 of 15
Yes
No
3 of 15
No
No
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
3 of 12
Yes
No
3 of 12
Yes
No
3 of 12
Yes
No
2 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906FE )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508BV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W054V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05VR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G090I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
3 of 10
3 of 10
2 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Component of the Frs-CycA-Cdk1 complex composed of CycA, Cdk1 and Z600. Interacts (via C-terminus) with Z600.
    (UniProt, P14785 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-37
    Cytogenetic map
    Sequence location
    3L:11,826,719..11,833,578 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    68E1-68E1
    Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    68E1-68E2
    (determined by in situ hybridisation)
    68D-68E
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (24)
    Genomic Clones (22)
    cDNA Clones (368)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: CycA CG5940
    Source for database merge of
    Source for merge of: CycA anon-WO0140519.128
    Additional comments
    Source for merge of CycA anon-WO0140519.128 was sequence comparison ( date:051113 ).
    Other Comments
    The CycA protein inhibits the premature degradation of mitotic cyclins and stg protein by negatively regulating the rap protein.
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
    CycA is required for entry into mitosis.
    The presence of the N terminal region is not required for CycAs function in mitotic entry.
    CycA degradation facilitates chromosome disjunction.
    Two EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
    Candidate gene for tibia length quantitative trait locus.
    Candidate gene for quantitative trait (QTL) locus determining bristle number.
    CycA regulates the nuclear changes while CycB regulates cytoskeletal changes in syncytial preblastoderm embryos.
    A balance of CycA and CycB proteins seems necessary for proper coordination during the embryonic cycles.
    numb functions downstream of cell division genes (CycA, Rca1 and stg) and progression through the cell cycle is required for asymmetric localisation of numb and thus N mediated specification of the sib fate in the RP2/sib division.
    The loss of CycA, Rca1 or stg leads to a block in the division of GMC-1, however this GMC-1 adopts a RP2 identity.
    Double and triple mutant analyses show that CycB3, CycB and CycA cooperate during mitosis.
    Rca1 positively regulates CycA by modulating CycA protein levels.
    CycA is misexpressed in the PNS of da mutant embryos.
    CycA protein can drive the G1/S transition in embryos, but this function is suppressed by three types of control: destruction of CycA protein, inhibitory phosphorylation of cdc2 and inhibition by rux.
    Ectopic rux converts the mitotic cycle into an endoreplication cycle by down-regulating CycA-associated kinase activity.
    Cloning and sequencing of CycA reveals a sequence identical to DRE (DNA replication-related element) in the region of nucleotide positions -71 to -64 with respect to the transcription initiation site. The role of the DRE in promoter activity is studied and results indicate CycA is under the control of the DRE/Dref system.
    Heterozygosity for CycA is not sufficient for females to produce viable homozygous kni mutant progeny. Double heterozygotes for CycA and CycB increase the efficiency for kni mutant rescue suggesting the cyclins interact synergistically.
    Observations in CycA mutants implicate G2 cyclins in reinitiation of DNA replication during the G2 phase of the mitotic cell cycle.
    Comparison of the fzy mutant phenotype with the phenotype resulting from expression of N-terminal truncated CycA, CycB or CycB3 suggests that fzy is not required for mitotic cyclin degradation alone, because fzy mutations, but not truncated cyclins, block chromosome separation.
    rux acts genetically to negatively regulate CycA.
    During development, changing levels of cell cycle regulators alters the rate limiting step and the mechanism governing progress of the cell cycle.
    Mutation in CycA affects cell division in the neuronal lineage.
    CycA is required for PNS development in the embryo.
    CycA transcripts injected into the syncytial blastoderm do not become incorporated to the pole cells, as CycB transcripts do.
    The CycA product has a mitotic function and acts synergistically with CycB during the G2-M transition.
    As part of an investigation into the effects of 37oC heat shock on G2-phase cycle 14 embryos, the degradation of cyclin A and cyclin B in the resulting synchronised mitotic domains was shown to be delayed.
    CycA gene product is not required for the continued rounds of DNA replication in the ventral cord or in endoreplicating tissues during embryonic development.
    A functional CycA gene is required for continued cell division after exhaustion of maternally provided cyclin A.
    Maternal message uniformly distributed in newly laid egg, but becomes more concentrated in the cortex prior to peripheral nuclear migration. At the time of cellularization of the blastoderm, zygotic message is produced. Cyclin A accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded during metaphase. Message confined to dividing tissues in brain and imaginal discs in larvae.
    CycA and CycB are coexpressed in all proliferating cells throughout development.
    CycA has a role in the G2 to M transition, independent of spindle formation.
    CycA is required for cell cycle progression.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 81 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (34)
    Reported As
    Symbol Synonym
    CycA
    (Liao et al., 2019, Rivera et al., 2019, Rotelli et al., 2019, Eusebio et al., 2018, Flora et al., 2018, Gene Disruption Project members, 2018-, Hakes et al., 2018, Hao et al., 2018, Otsuki and Brand, 2018, Swevers et al., 2018, Wu et al., 2018, Hara et al., 2017, Housden et al., 2017, Ji et al., 2017, Liu et al., 2017, Martins et al., 2017, Neto et al., 2017, Neuert et al., 2017, Recasens-Alvarez et al., 2017, Siddall and Hime, 2017, Tomita et al., 2017, Transgenic RNAi Project members, 2017-, Weber and Mlodzik, 2017, Chandra et al., 2016, Gomez et al., 2016, Meghini et al., 2016, Qi and Calvi, 2016, Varadarajan et al., 2016, Afonso et al., 2015, Afonso et al., 2015, Bergman et al., 2015, Di Cara et al., 2015, Doggett et al., 2015, Gene Disruption Project members, 2015-, Matsuda et al., 2015, Wang and Baker, 2015, Ashwal-Fluss et al., 2014, Butí et al., 2014, Eliazer et al., 2014, Frost et al., 2014, Günesdogan et al., 2014, Hassel et al., 2014, Parsons et al., 2014, Singh et al., 2014, Bandura et al., 2013, Bonke et al., 2013, Chang et al., 2013, Lehner, 2013.1.1, Lu et al., 2013, Mishra et al., 2013, Neumüller et al., 2013, Noatynska et al., 2013, Saunders et al., 2013, Schertel et al., 2013, Yin et al., 2013, Zhou and Luo, 2013, Farrell et al., 2012, Ito et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ruggiero et al., 2012, Sallé et al., 2012, Tokusumi et al., 2012, van der Harst et al., 2012, Xu et al., 2012, Xu et al., 2012, Yuan et al., 2012, Bangi et al., 2011, Chen et al., 2011, Gilbert et al., 2011, Lindquist et al., 2011, Noyes et al., 2011, Poulton et al., 2011, Richter et al., 2011, Beam and Moberg, 2010, Beck et al., 2010, Biehs et al., 2010, Fox et al., 2010, Li et al., 2010, Monk et al., 2010, Swaminathan et al., 2010, Tastan et al., 2010, zur Lage and Jarman, 2010, Althoff et al., 2009, McCleland et al., 2009, Peng and Karpen, 2009, Shyu et al., 2009, Southall and Brand, 2009, Bakal et al., 2008, Benoit et al., 2008, Bowman et al., 2008, Caussinus et al., 2008, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Lee et al., 2008, O'Farrell and Kylsten, 2008, Sato et al., 2008, Shimizu et al., 2008, Ambrus et al., 2007, Beltran et al., 2007, Escudero and Freeman, 2007, Franklin-Dumont et al., 2007, Gawlinski et al., 2007, Gawlinski et al., 2007, Griffiths et al., 2007, Großhans et al., 2007, Johnson et al., 2007, Kankel et al., 2007, Kugler and Nagel, 2007, LaRocque et al., 2007, LaRocque et al., 2007, Lecuyer et al., 2007, Link et al., 2007, Magalhaes et al., 2007, Minakhina et al., 2007, Pfleger et al., 2007, Ramachandran et al., 2007, Sandmann et al., 2007, Sun and Deng, 2007, Swan and Schupbach, 2007, Tanaka-Matakatsu et al., 2007, Tanaka-Matakatsu et al., 2007, Friedman and Perrimon, 2006, Jones et al., 2006, Jordan et al., 2006, Khurana et al., 2006, Morris et al., 2006, Mukherjee et al., 2006, Sugimura and Lilly, 2006, Vrailas and Moses, 2006, Zielke et al., 2006, Baonza and Freeman, 2005, Greene et al., 2005, Stanyon et al., 2004, Heriche et al., 2003, Leismann and Lehner, 2003, Huang and Raff, 2002)
    anon-WO0140519.128
    hari
    l(3)03946
    l(3)68Ea
    l(3)j3C8
    l(3)neo114
    l(3)rsg11
    Name Synonyms
    Suppressor of rux 3B
    rose-gespleten region interval 11
    Secondary FlyBase IDs
    • FBgn0010826
    • FBgn0011353
    • FBgn0044754
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (588)