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Gene Dmel\CycA

General Information
Symbol	Dmel\CycA	Species	D. melanogaster
Name	Cyclin A	Annotation symbol	CG5940
Feature type	protein_coding_gene	FlyBase ID	FBgn0000404
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	DmcycA
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	68E1-68E1	Sequence location	3L:11,819,818..11,826,695 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclin A is referred to in FlyBase by the symbol Dmel\CycA (CG5940, FBgn0000404). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; cyclin-dependent protein kinase regulator activity. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; cell cycle; cellular component organization or biogenesis; anatomical structure development; multicellular organismal process; regulation of biological process; cell fate commitment; cell cycle process; cell-cell signaling; nuclear division. 100 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; embryonic/larval neuron; nervous system; ventral nerve cord primordium; germarium; cell cycle; external compound sense organ; female germline cyst; primordium. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cyclin A, G2/mitotic-specific; Cyclin A/B/D/E; Cyclin, C-terminal; Cyclin, N-terminal; Cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639195_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CycA. Gene sequence location is 3L:11819818..11826695.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	CycA: Cyclin A Encodes cyclin, a molecule involved in the cell cycle; the pattern of transcription reflects this. Maternal message uniformly distributed in newly laid egg, but becomes more concentrated in the cortex prior to peripheral nuclear migration. At the time of cellularization of the blastoderm, zygotic message is produced. Cyclin A accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded during metaphase. A functional cyclin A gene is required for continued cell division after exhaustion of maternally provided cyclin A. Message confined to dividing tissues in brain and imaginal disks in larvae.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Monk et al., 2010, Cell Stem Cell 6(4): 348--360 Gilbert et al., 2011, Dev. Cell 20(5): 700--712 Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Sequence features HFA11123 HFA09132 BKN21599
FB2011_10	References Yin et al., 2008, BMC Bioinformatics 9: 264 Controlled Vocabulary Terms regulation of chromatin binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68E1-68E1   Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map Notes References 68E1-68E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 68E-68E   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 68E-68E   (determined by in situ hybridisation)   (Salzberg et al., 1997) 68E-68E   (determined by in situ hybridisation)   (Deak et al., 1997) 68E1-68E2   68E1--3   (BDGP Project Members, 1994-1999) 68D-68E   (determined by in situ hybridisation)   (Berg and Spradling, 1991) 68E-68E   (determined by in situ hybridisation)   (Whitfield et al., 1990) 68E-68E   (determined by in situ hybridisation)   (Whitfield et al., 1989) 68D-68E   (determined by in situ hybridisation)   (Lehner and O'Farrell, 1989) 68D-68E   (determined by in situ hybridisation)   (Cooley et al., 1988)
Experimentally Determined Recombination Data
Location	3-37.6-39 (Salzberg et al., 1994) 3-37 (Dong et al., 1997)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CycA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CycA-RA FBtr0076075  NM_079306   2572   491 CycA-RB FBtr0076076  NM_168483   1938   345 CycA-RC FBtr0304650     2934   490 CycA-RD FBtr0304651     2268   345
Additional Transcript Data & Comments
Reported size (kB)	3.0, 2.7 (northern blot) (Lehner and O'Farrell, 1989) 2.504 (longest cDNA) (Takahisa et al., 1992) 2.5, 2.3 (northern blot) (Whitfield et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CycA-PA   FBpp0075807   56.2   491   5.73     NP_524030   AAF49999 CycA-PB   FBpp0075808   40.3   345   5.32     NP_729756   AAF50000 CycA-PC   FBpp0293192   56.0   490   5.73       CycA-PD   FBpp0293193   40.3   345   5.32
Additional Polypeptide Data & Comments
Reported size (kDa)	491 (aa); 61 (kD) (Lehner and O'Farrell, 1989) 491 (aa) (Takahisa et al., 1992) 60 (kD) (Whitfield et al., 1990)
Comments	CycA protein levels increase in eye discs in response to ectopic expression of Rca1. (Dong et al., 1997)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, C-terminal (IPR004367) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763) Cyclin A/B/D/E (IPR014400) Cyclin A, G2/mitotic-specific (IPR015453)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201423   AA201829   AA201907   AA202452   AA202850   AA202951   AA246290   AA246554   AA246701   AA263269   AA263325   AA263500   AA263857   AA263919   AA263995   AA264576   AA390661   AA391765   AA391796   AA392228   AA438992   AA439203   AA439794   AA439948   AA439972   AA440387   AA441635   AA541023   AA541235   AA567063   AA696233   AA802097   AA816670   AA816683   AA816857   AA816860   AA948868   AA949820   AA950772   AA951442   AA951876   AA952052   AA952102   AE014296 AAF49999   AE014296 AAF50000   AI239241   AI293739   AI455077   AI456048   AI456171   AI456319   AI511718   AI511912   AI512131   AI512171   AI512541   AI514447   AI514838   AI515329   AI515368   AI515493   AI515703   AI515708   AI516129   AI516372   AI516611   AI518484   AI518646   AI518883   AI519186   AI532887   AI533302   AI533314   AI533324   AI534475   AI542620   AI542747   AI546124   AI546149   AI546154   AW943723   AX154779   AY058712 AAL13941   BE978080   BF501197   BF502524   BG633796   BG634927   BG638666   BG638909   BI163139   BI163217   BI163348   BI163373   BI163552   BI163570   BI163672   BI165047   BI165473   BI165475   BI165488   BI166249   BI166423   BI166441   BI166838   BI167244   BI167310   BI167509   BI167803   BI168386   BI169579   BI169768   BI170059   BI170372   BI170975   BI171023   BI172649   BI172715   BI172764   BI173575   BI212923   BI213042   BI213698   BI213750   BI214495   BI216866   BI227449   BI228443   BI228538   BI228540   BI231117   BI233235   BI233265   BI235444   BI235619   BI236461   BI236795   BI237830   BI238450   BI238557   BI239084   BI239672   BI239803   BI240257   BI240638   BI241019   BI241562   BI241691   BI242390   BI243093   BI357434   BI358025   BI358597   BI361336   BI361839   BI363018   BI363290   BI364072   BI364520   BI365288   BI365294   BI365299   BI366219   BI368011   BI368212   BI368598   BI368776   BI369804   BI370041   BI371207   BI371660   BI374765   BI375254   BI481769   BI482949   BI483167   BI483656   BI483975   BI484098   BI484249   BI484434   BI485194   BI485572   BI486249   BI486963   BI487196   BI577135   BI577138   BI577806   BI578119   BI578299   BI579075   BI579289   BI580179   BI635956   BI636010   BP550258   BQ103626   BT001635 AAN71390   BT126325   BT126364   CK605039   CK605040   CK657785   CL868508   CO189471   CO269847   CO276217   CO277122   CO277703   CO290216   CO294395   CO294758   CO304133   CO305018   CO305956   CO306218   CO307086   CO311427   CO313800   CO315743   CO316980   CO317716   CO322765   CO330685   CO331891   CO332426   CO340752   CZ470816   CZ470904   D10856 BAA01628   D10857 BAA01628   D10858 BAA01629   EC051797   EC065978   EC066642   EC070340   EC076264   EC076297   EC076527   EC076676   EC077440   EC077507   EC079200   EC082926   EC203914   EC204093   EC206794   EC211945   EC213637   EC226171   EC227933   EC232241   EC249802   EC251136   EC259306   EV574840   EV575245   EV576645   EV582157   EV582488   EV582776   EV590345   EV592523   EV593871   EV595184   EV595637   EV598620   EV599814   G00572   G00718   G01162   GH750266   GH751326   GH751526   GH755016   GH755958   GH756305   GH756964   GH760754   GH770363   GH772439   GH776232   GH776906   GH782915   GH783977   GH784055   GH784652   GH785807   GH788277   GH789996   GH792549   GH793372   GH793793   GH796048   GH801941   GH804223   GH804438   GH807423   GH808610   GH808686   GH808787   GH810113   GH813265   GH814230   GH814250   GH816721   GH817854   GH819551   GH823194   GH824310   GH824483   GH825190   GH828189   GH830729   GH831988   GH832965   GH833325   GH834138   GH834229   GH834687   GH836140   GH837165   GH837221   GH840438   GH841387   GH843130   GH844978   GH846315   GH847465   GH848259   GH848358   GH851679   GH852418   GH854123   GH858071   GH863021   GH863379   GH868247   GH871078   GH871239   GH873139   GH876568   GH877707   GH878602   GH879404   GH879998   GH881601   GH884606   GH885118   GH886787   GH889894   GH890043   GH890539   GH893075   GH896258   GH897064   GH898000   GH898648   GH898714   GH899459   GH899542   GH902722   GH905618   GH907675   GH912102   GH913101   GH915169   GH915258   GH915854   GH916716   GH922020   GH922577   GH924684   GH925303   GH925423   GH925529   GH927586   GH928524   GH929143   GH929251   GH931930   GH933403   GH934563   GH937898   M24841 AAA28435
UniProtKB/Swiss-Prot	P14785
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism   • yolk plasma | posterior (Lecuyer et al., 2007) embryonic stage 5   pole cell   (Lecuyer et al., 2007) adult stage | male   testis | restricted   (Perezgasga et al., 2004) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Whitfield et al., 1989) organism   (Whitfield et al., 1989) embryonic stage     (Lehner and O'Farrell, 1989) embryonic stage -- adult stage     (Whitfield et al., 1989) larval stage   imaginal disc   (Whitfield et al., 1989) embryonic/larval brain   (Whitfield et al., 1989) adult stage | female   ovary   (Dalby and Glover, 1992)   (Whitfield et al., 1989, Dalby and Glover, 1992) adult stage & oogenesis   germarium   (Dalby and Glover, 1992) oogenesis stage S9 -- S10 & adult stage | female   nurse cell   (Dalby and Glover, 1992)
Additional Descriptive Data
Marker for
	testis
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Lehner and O'Farrell, 1989) larval stage   embryonic/larval central nervous system   (Whitfield et al., 1990) imaginal disc   (Lehner and O'Farrell, 1989) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   cell | subset   • cytoplasm (Foley et al., 1999) Comment:interphase cells embryonic stage 4     (Maldonado-Codina and Glover, 1992) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   peripheral nervous system   (Lehner and O'Farrell, 1989)   (Whitfield et al., 1990) embryonic stage | early     (Lehner and O'Farrell, 1989)
Additional Descriptive Data
	CycA protein is undetectable in unfertilized eggs and is present at low levels prior to cellularization of the syncytial embryo. The level rises in 3-4hr embryos, stays at a high level until 8hr, and then drops. Following cellularization, CycA protein levels are regulated during the cell cycle. CycA protein accumulates in cells prior to entry into M-phase, reaches peak levels in prophase, and is degraded as the chromosomes are becoming aligned on the metaphase plate. Similar cycling is observed in the larval CNS. (Maldonado-Codina et al., 1993, Whitfield et al., 1990) CycA protein is detected in embryonic extracts from different stages and is most prevalent in early embryos. After embryonic cycle 16, CycA protein is present exclusively in dividing cells including those of the embryonic CNS and PNS and larval imaginal discs. (Maldonado-Codina and Glover, 1992, Lehner and O'Farrell, 1989) CycA protein appears to be concentrated over the region of the condensing chromatin in prophase cells. CycA protein accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded within metaphase. (Maldonado-Codina and Glover, 1992, Lehner and O'Farrell, 1989)
Marker for
Subcellular Localization
CV Term	mitotic cycle (Maldonado-Codina et al., 1993) cytoplasm interphase mitotic cycle chromatin (Maldonado-Codina and Glover, 1992) cytoplasm nucleus mitotic cycle (Lehner and O'Farrell, 1989)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000404    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000404 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000404 expression level Developmental Stage   Expression Level embryo 00-02hr    49028 embryo 02-04hr    36693 embryo 04-06hr    37551 embryo 06-08hr    32055 embryo 08-10hr    25230 embryo 10-12hr    12085 embryo 12-14hr    8562 embryo 14-16hr    5035 embryo 16-18hr    3962 embryo 18-20hr    1761 embryo 20-22hr    5939 embryo 22-24hr    5581 larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6    2104 larva L3 puffstage 7-9    2793 white prepupae new    2922 white prepupae 12hr    3383 white prepupae 24hr    3589 pupae 2d postWPP    1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day    1550 adult male 30day    1407 adult female 01day    13222 adult female 05day    31241 adult female 30day    31447 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (49028) embryo 02-04hr  (36693) embryo 04-06hr  (37551) embryo 06-08hr  (32055) embryo 08-10hr  (25230) embryo 10-12hr  (12085) embryo 12-14hr  (8562) embryo 14-16hr  (5035) embryo 16-18hr  (3962) embryo 18-20hr  (1761) embryo 20-22hr  (5939) embryo 22-24hr  (5581) larva L1  (525) larva L2  (720) larva L3 12hr old  (571) larva L3 puffstage 1-2  (1252) larva L3 puffstage 3-6  (2104) larva L3 puffstage 7-9  (2793) white prepupae new  (2922) white prepupae 12hr  (3383) white prepupae 24hr  (3589) pupae 2d postWPP  (1608) pupae 3d postWPP  (950) pupae 4d postWPP  (1033) adult male 01day  (1050) adult male 05day  (1550) adult male 30day  (1407) adult female 01day  (13222) adult female 05day  (31241) adult female 30day  (31447) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (49028) embryo 02-04hr  (36693) embryo 04-06hr  (37551) embryo 06-08hr  (32055) embryo 08-10hr  (25230) embryo 10-12hr  (12085) embryo 12-14hr  (8562) embryo 14-16hr  (5035) embryo 16-18hr  (3962) embryo 18-20hr  (1761) embryo 20-22hr  (5939) embryo 22-24hr  (5581) larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6  (2104) larva L3 puffstage 7-9  (2793) white prepupae new  (2922) white prepupae 12hr  (3383) white prepupae 24hr  (3589) pupae 2d postWPP  (1608) pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day  (1550) adult male 30day  1407 adult female 01day  (13222) adult female 05day  (31241) adult female 30day  (31447) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (49028) embryo 02-04hr  (36693) embryo 04-06hr  (37551) embryo 06-08hr  (32055) embryo 08-10hr  (25230) embryo 10-12hr  (12085) embryo 12-14hr    8562 embryo 14-16hr    5035 embryo 16-18hr    3962 embryo 18-20hr    1761 embryo 20-22hr    5939 embryo 22-24hr    5581 larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6    2104 larva L3 puffstage 7-9    2793 white prepupae new    2922 white prepupae 12hr    3383 white prepupae 24hr    3589 pupae 2d postWPP    1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day    1550 adult male 30day    1407 adult female 01day  (13222) adult female 05day  (31241) adult female 30day  (31447) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    49028 embryo 02-04hr    36693 embryo 04-06hr    37551 embryo 06-08hr    32055 embryo 08-10hr    25230 embryo 10-12hr    12085 embryo 12-14hr    8562 embryo 14-16hr    5035 embryo 16-18hr    3962 embryo 18-20hr    1761 embryo 20-22hr    5939 embryo 22-24hr    5581 larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6    2104 larva L3 puffstage 7-9    2793 white prepupae new    2922 white prepupae 12hr    3383 white prepupae 24hr    3589 pupae 2d postWPP    1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day    1550 adult male 30day    1407 adult female 01day    13222 adult female 05day    31241 adult female 30day    31447 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000404 expression level Developmental Stage   Expression Level embryo 00-02hr    49028 embryo 02-04hr    36693 embryo 04-06hr    37551 embryo 06-08hr    32055 embryo 08-10hr    25230 embryo 10-12hr    12085 embryo 12-14hr    8562 embryo 14-16hr    5035 embryo 16-18hr    3962 embryo 18-20hr    1761 embryo 20-22hr    5939 embryo 22-24hr    5581 larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6    2104 larva L3 puffstage 7-9    2793 white prepupae new    2922 white prepupae 12hr    3383 white prepupae 24hr    3589 pupae 2d postWPP    1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day    1550 adult male 30day    1407 adult female 01day    13222 adult female 05day    31241 adult female 30day    31447 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (49028) embryo 02-04hr  (36693) embryo 04-06hr  (37551) embryo 06-08hr  (32055) embryo 08-10hr  (25230) embryo 10-12hr  (12085) embryo 12-14hr  (8562) embryo 14-16hr  (5035) embryo 16-18hr  (3962) embryo 18-20hr  (1761) embryo 20-22hr  (5939) embryo 22-24hr  (5581) larva L1  (525) larva L2  (720) larva L3 12hr old  (571) larva L3 puffstage 1-2  (1252) larva L3 puffstage 3-6  (2104) larva L3 puffstage 7-9  (2793) white prepupae new  (2922) white prepupae 12hr  (3383) white prepupae 24hr  (3589) pupae 2d postWPP  (1608) pupae 3d postWPP  (950) pupae 4d postWPP  (1033) adult male 01day  (1050) adult male 05day  (1550) adult male 30day  (1407) adult female 01day  (13222) adult female 05day  (31241) adult female 30day  (31447) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (49028) embryo 02-04hr  (36693) embryo 04-06hr  (37551) embryo 06-08hr  (32055) embryo 08-10hr  (25230) embryo 10-12hr  (12085) embryo 12-14hr  (8562) embryo 14-16hr  (5035) embryo 16-18hr  (3962) embryo 18-20hr  1761 embryo 20-22hr  (5939) embryo 22-24hr  (5581) larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6  2104 larva L3 puffstage 7-9  (2793) white prepupae new  (2922) white prepupae 12hr  (3383) white prepupae 24hr  (3589) pupae 2d postWPP  1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day  1550 adult male 30day  1407 adult female 01day  (13222) adult female 05day  (31241) adult female 30day  (31447) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (49028) embryo 02-04hr  (36693) embryo 04-06hr  (37551) embryo 06-08hr  (32055) embryo 08-10hr  (25230) embryo 10-12hr  12085 embryo 12-14hr    8562 embryo 14-16hr    5035 embryo 16-18hr    3962 embryo 18-20hr    1761 embryo 20-22hr    5939 embryo 22-24hr    5581 larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6    2104 larva L3 puffstage 7-9    2793 white prepupae new    2922 white prepupae 12hr    3383 white prepupae 24hr    3589 pupae 2d postWPP    1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day    1550 adult male 30day    1407 adult female 01day  13222 adult female 05day  (31241) adult female 30day  (31447) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    49028 embryo 02-04hr    36693 embryo 04-06hr    37551 embryo 06-08hr    32055 embryo 08-10hr    25230 embryo 10-12hr    12085 embryo 12-14hr    8562 embryo 14-16hr    5035 embryo 16-18hr    3962 embryo 18-20hr    1761 embryo 20-22hr    5939 embryo 22-24hr    5581 larva L1    525 larva L2    720 larva L3 12hr old    571 larva L3 puffstage 1-2    1252 larva L3 puffstage 3-6    2104 larva L3 puffstage 7-9    2793 white prepupae new    2922 white prepupae 12hr    3383 white prepupae 24hr    3589 pupae 2d postWPP    1608 pupae 3d postWPP    950 pupae 4d postWPP    1033 adult male 01day    1050 adult male 05day    1550 adult male 30day    1407 adult female 01day    13222 adult female 05day    31241 adult female 30day    31447 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000404    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000404 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000404 expression level Tissue   Expression Level Larval Central Nervous System    748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary    2641.7 Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (748.725) Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary  (2641.7) Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary  (2641.7) Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary    2641.7 Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000404 expression level Tissue   Expression Level Larval Central Nervous System    748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary    2641.7 Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary  (2641.7) Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary  (2641.7) Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    748.725 Larval Midgut    51.2 Larval Hindgut    88.5 Larval Malpighian Tubules    19.2 Larval Fat Body    101.2 Larval Salivary Gland    75.4 Larval Trachea    188 Larval Carcass    85.45 Adult Head    17.4 Adult Eye no informative data Adult Brain    13.7 Adult Thoracic-Abdominal Ganglion    19.5 Adult Crop    20.6 Adult Midgut    35.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    34.5 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    35.8 Adult InseminatedFemale Spermatheca    20.7 Adult Ovary    2641.7 Adult Testis    261.3 Adult Male Accessory Gland no informative data Adult Carcass    87.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    17.4   NA  Eye    no informative data   NA  Brain    13.7   748.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    19.5   NA  Crop    20.6   51.2  Midgut    35.4   88.5  Hindgut    no informative data   19.2  Malpighian Tubules    no informative data   101.2  Fat Body    34.5   75.4  Salivary Gland    no informative data   NA  Heart    no informative data   188  Trachea    NA   NA  VirginFemale Spermatheca    35.8   NA  InseminatedFemale Spermatheca    20.7   NA  Ovary    2641.7   NA  Testis    261.3   NA  Male Accessory Gland    no informative data   85.45  Carcass    87.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5940-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CycA Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CycAGD8653 lethal (with Df(3L)vin7) CycAS004623 CycAS010407 CycAS024534 CycAS052106 CycAS054513 CycAS144905 lethal | adult stage | recessive CycAS004024 CycAS004623 lethal | embryonic stage | recessive CycAS003302a CycAS010407 CycAS024534 CycAS052106 CycAS052118 CycAS052119 CycAS144905 CycAS144911 CycAS144914 lethal | larval stage | recessive CycAS054513 CycAS132916 lethal | recessive CycA3 CycA5 CycA01545 CycA01558 CycA02461 CycA03946 CycAH170 CycAj1E5 CycAj3C8 CycAL90 CycAry40 CycAS003302a CycAS004024 CycAS004623 CycAS010407 CycAS024534 CycAS052106 CycAS054513 CycAS132916 CycAS144905 semi-lethal CycA03946 semi-lethal | recessive CycA03946 CycAS004024 CycAS004623 viable, with Scer\GAL4pnr-MD237 CycAGD8653 viable | reduced, with Scer\GAL4da.G32 CycAScer\UAS.T:Ivir\HA1 Other Phenotypes Allele mitotic cell cycle defective CycA3 CycAC8LR1 CycAhs.PK mitotic cell cycle defective, with Scer\GAL4hs.2sev CycAScer\UAS.T:Ivir\HA1,T:Hsap\nes3 CycAScer\UAS.T:Ivir\HA1,T:SV40\nls2 CycAScer\UAS.T:Ivir\HA1 mitotic cell cycle defective, with Scer\GAL4prd.RG1 CycAδ1-13,32-53.Scer\UAS CycAδ1-31,39-44.Scer\UAS CycAδ1-31,46-54.Scer\UAS CycAδ1-38.Scer\UAS CycAδ1-53.Scer\UAS CycAδ1-83.Scer\UAS CycAδ1-109.Scer\UAS CycAδ1-131.Scer\UAS CycAδ17-53.Scer\UAS CycAδ32-53.Scer\UAS mitotic cell cycle defective | embryonic stage CycA5 CycAC8LR1 CycAΔ.T:Ivir\HA1 mitotic cell cycle defective | embryonic stage (with CycA3) CycA5 mitotic cell cycle defective | embryonic stage (with CycA5) CycA3 neuroanatomy defective CycA3 neuroanatomy defective | embryonic stage CycAC8LR1 neuroanatomy defective | larval stage, with Scer\GAL41407 CycAGD8653 visible, with Scer\GAL4da.G32 CycAScer\UAS.T:Ivir\HA1 visible, with Scer\GAL4pnr-MD237 CycAGD8653 visible | recessive CycAhari wild-type CycA+t13 CycAhs.PK Phenotype manifest in Allele abdominal segment 2 & cardioblast CycAC8LR1 abdominal segment 3 & cardioblast CycAC8LR1 abdominal segment 4 & cardioblast CycAC8LR1 abdominal segment 5 & cardioblast CycAC8LR1 abdominal segment 6 & cardioblast CycAC8LR1 abdominal segment 7 & cardioblast CycAC8LR1 aCC neuron | precursor CycA04335 amnioserosa CycAhs.PK anaphase & condensed nuclear chromosome CycAΔ55.T:Ivir\HA1 CycAS.hs cardioblast CycAC8LR1 cell cycle CycAΔ55.T:Ivir\HA1 CycAK13A.Δ40-86.T:Ivir\HA1 CycAS.hs chaeta, with Scer\GAL4da.G32 CycAScer\UAS.T:Ivir\HA1 chaeta, with Scer\GAL4pnr-MD237 CycAGD8653 chordotonal organ CycAH170 CycAL90 commissure CycAunspecified dorsal neurohemal organ CycA3 egg chamber CycAhs.PK egg chamber & cell CycAΔ.T:Ivir\HA1 CycAhs.PK egg chamber & mitotic cell cycle CycAΔ.T:Ivir\HA1 CycAhs.PK EL neuron CycA5 embryonic/larval dorsal trunk (with Df(3L)vin3) CycA5 embryonic/larval glial cell CycAC8LR1 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CycAGD8653 embryonic/larval salivary gland | embryonic stage, with Scer\GAL4F4 CycAScer\UAS.cWa embryonic/larval transverse connective (with Df(3L)vin3) CycA5 embryonic epidermis CycA3 CycA5 CycAC8LR1 embryonic epidermis (with CycA3) CycA5 embryonic epidermis (with CycA5) CycA3 embryonic epidermis | embryonic cycle 16 CycAC8LR1 embryonic ganglion mother cell CycAC8LR1 embryonic pericardial cell CycAC8LR1 EW neuron CycA3 eye CycAhs.PK eye, with Scer\GAL4da.G32 CycAScer\UAS.T:Ivir\HA1 eye disc, with Scer\GAL4GMR.PF CycAScer\UAS.cWa female germline stem cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 CycAΔ.Scer\UAS.P\T ganglion mother cell | larval stage, with Scer\GAL41407 CycAGD8653 ganglion mother cell GMC1-1a CycA5 ganglion mother cell GMC4-2a CycA04335 CycA5 CycAC8LR1 germarium, with Scer\GAL4nos.UTR.T:Hsim\VP16 CycAΔ.Scer\UAS.P\T GW neuron CycA3 longitudinal connective CycAunspecified mesothoracic tergum, with Scer\GAL4pnr-MD237 CycAGD8653 metaphase & condensed nuclear chromosome CycAS.hs mitotic cell cycle CycAΔ55.T:Ivir\HA1 CycA3 CycAC8LR1 CycAK13A.Δ40-86.T:Ivir\HA1 CycAhs.PK mitotic cell cycle, with Scer\GAL4prd.RG1 CycAδ1-53.Scer\UAS CycAScer\UAS.Δ170 mitotic cell cycle & epidermis & embryo CycAS.hs CycAhs.PK mitotic cell cycle & eye CycAhs.sev neuroblast NB6-4 of abdomen CycA3 neuroblast NB6-4 of thorax CycA3 neuroblast NB7-3 CycA3 neuron & peripheral nervous system CycAH170 CycAL90 neuron | embryonic stage CycAS003302a CycAS004024 CycAS004623 CycAS010407 CycAS024534 CycAS052106 CycAS052118 CycAS052119 CycAS054513 CycAS132916 CycAS144905 CycAS144911 CycAS144914 nurse cell fusome CycAΔ.T:Ivir\HA1 ommatidium, with Scer\GAL4da.G32 CycAScer\UAS.T:Ivir\HA1 pCC neuron CycA04335 pCC neuron | precursor CycA04335 pole cell CycAhs.PK presumptive embryonic/larval central nervous system CycAunspecified RP2sib neuron CycA04335 CycAC8LR1 S phase | ectopic CycAC8LR1 CycAhs.PK S phase | ectopic, with Scer\GAL4hs.2sev CycAScer\UAS.T:Ivir\HA1 CycAScer\UAS.T:Ivir\HA1,T:Hsap\nes3 CycAScer\UAS.T:Ivir\HA1,T:SV40\nls2 U neuron CycA04335
Classical Alleles ( 42 )
For All Classical Alleles Show
Allele of CycA Class Mutagen Stocks Known lesion CycA03946 P-element activity 2 -- CycAc05304 piggyBac transposase 2 -- CycAC8LR1 amorphic allele - genetic evidence 1 -- CycA5-HA-1817 1 -- CycAc06568 piggyBac transposase 1 -- CycACB-5550-3 1 -- CycAEY11746 P-element activity 1 -- CycAG9446 P-element activity 1 -- CycAH170 ethyl methanesulfonate 1 -- CycANP1609 1 -- CycA3 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes CycAhari amorphic allele - genetic evidence P-element activity 0 Yes CycA01545 P-element activity 0 -- CycA01558 P-element activity 0 -- CycA02461 P-element activity 0 -- CycA04335 P-element activity 0 -- CycA1 ethyl methanesulfonate 0 -- CycA2 ethyl methanesulfonate 0 -- CycA4 ethyl methanesulfonate 0 -- CycA5 P-element activity PM hybrid dysgenesis 0 Yes CycAc06664 piggyBac transposase 0 -- CycAH116 P-element activity 0 Yes CycAj1E5 P-element activity 0 Yes CycAj3C8 P-element activity 0 Yes CycAL90 ethyl methanesulfonate 0 -- CycArO545 P-element activity 0 -- CycAry40 P-element activity 0 -- CycAS(rux)3B ethyl methanesulfonate X ray 0 -- CycAS003302a Delta2-3 P-element activity 0 -- CycAS004024 Delta2-3 P-element activity 0 -- CycAS004623 Delta2-3 P-element activity 0 -- CycAS010407 Delta2-3 P-element activity 0 -- CycAS024534 Delta2-3 P-element activity 0 -- CycAS052106 Delta2-3 P-element activity 0 -- CycAS052118 P-element activity 0 -- CycAS052119 P-element activity 0 -- CycAS054513 Delta2-3 P-element activity 0 -- CycAS132916 Delta2-3 P-element activity 0 -- CycAS144905 Delta2-3 P-element activity 0 -- CycAS144911 P-element activity 0 -- CycAS144914 P-element activity 0 -- CycAunspecified 0 --
Alleles Carried on Transgenic Constructs ( 58 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CycA Class Mutagen Stocks Known lesion CycAGD8653 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycAGLV21059 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycAHM04073 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycAJF02472 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycAKK101548 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CycAScer\UAS.cWa in vitro construct - regulatory fusion 1 Yes CycA+t13 in vitro construct - genomic fragment 0 Yes CycA1-170.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAA1 in vitro construct 0 Yes CycAdbs1m.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes CycAdsRNA.cHa in vitro construct - RNAi 0 Yes CycAhs.PK in vitro construct - regulatory fusion 0 Yes CycAhs.sev in vitro construct - regulatory fusion 0 Yes CycAK13A.Δ22-55.T:Ivir\HA1 in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes CycAK13A.Δ40-86.T:Ivir\HA1 in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes CycAK13A.Δ42-55.Δ158-171.T:Ivir\HA1 in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes CycAK13A.Δ55-70.T:Ivir\HA1 in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes CycAK13A.Δ55-86.T:Ivir\HA1 in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes CycAMtnA.PA in vitro construct - regulatory fusion 0 Yes CycAMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycAS.hs in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes CycAScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes CycAScer\UAS.P\T.cCa in vitro construct - regulatory fusion 0 Yes CycAScer\UAS.T:Ivir\HA1,T:Hsap\nes3 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycAScer\UAS.T:Ivir\HA1,T:SV40\nls2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycAScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CycAScer\UAS.Δ170 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes CycAT:Ivir\HA1 in vitro construct 0 Yes CycAΔ.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes CycAΔ.T:Ivir\HA1 in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-109.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-13,32-53.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-131.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-31,39-44.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-31,46-54.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-38.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-53.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδ1-83.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAΔ158-171.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAδ17-53.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAΔ170.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ22-55.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ25.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ30.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAδ32-53.Scer\UAS in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAΔ40-70.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ40-86.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ42-55.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ42-55.Δ158-171.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ42.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ50.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ55-70.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ55-86.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ55.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ70.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAΔ80.T:Ivir\HA1 in vitro construct - deletion 0 Yes CycAδdbs2-1m.Scer\UAS.T:Hsap\MYC in vitro construct - deletion in vitro construct - coding region fusion 0 Yes CycAδdbs2.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC676 (Christensen et al., 2008.12.28) Df(3L)BSC727 (Christensen et al., 2008.12.28) Df(3L)Exel6115 (Ryder, 2004.4.26) Df(3L)P20 (Hoogwerf et al., 1988) Df(3L)vin3 (Hoogwerf et al., 1988, Lehner and O'Farrell, 1989, Ueda et al., 1992) Df(3L)vin4 (Hoogwerf et al., 1988) Df(3L)vin5 (Szeged Stock Center, 1998-, Spradling et al., 1999, Hoogwerf et al., 1988) Df(3L)vin6 (Hoogwerf et al., 1988) Df(3L)vin7 (Szeged Stock Center, 1998-, Spradling et al., 1999, Hoogwerf et al., 1988, Smith et al., 1993, BDGP Project Members, 1994-1999, Deak et al., 1997) Df(3L)vin8 (Hoogwerf et al., 1988) Df(3L)vin9 (Hoogwerf et al., 1988)
Not disrupted in	Df(3L)vin2 (Hoogwerf et al., 1988, Lehner and O'Farrell, 1989) Df(3L)vin10 (Hoogwerf et al., 1988) Df(3L)vin11 (Hoogwerf et al., 1988) Df(3L)vin66 (Hoogwerf et al., 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8653} NA P{KK101548} NA P{TRiP.GLV21059} NA P{TRiP.HM04073} NA P{TRiP.JF02472} NA P{UAS-CycA.dbs1m} NA P{UAS-CycA.H} NA P{UAS-CycA.HA-NES} NA P{UAS-CycA.HA-NLS} NA P{UAS-CycA.W} NA P{UAS-CycA.δ1-13,32-53} NA P{UAS-CycA.δ1-31,39-44} NA P{UAS-CycA.δ1-31,46-54} NA P{UAS-CycA.δ1-38} NA P{UAS-CycA.δ1-53} NA P{UAS-CycA.δ1-83} NA P{UAS-CycA.δ1-109} NA P{UAS-CycA.δ1-131} NA P{UAS-CycA.δ17-53} NA P{UAS-CycA.δ32-53} NA P{UAS-CycA.δdbs2-1m} NA P{UAS-CycA.δdbs2} NA P{UAS-CycA-Δ170} NA P{UASp-CycA.C} NA P{UASp-CycA.Δ} NA heat-shock construct P{CycAhs.sev} NA P{hs-CycA} NA P{HS-CycAS} NA reporter construct P{CycA.AZB-1} No P{CycA.AZB-2} No characterization construct P{CycA+} NA P{Hs-ΔcyclinA} NA P{UAS-CycA.HA} NA P{UAS-tor-HA-CycA} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}CycAj1E5 No P{lacW}CycAj3C8 No P{lacW}CycAS003302a No P{lacW}CycAS004024 No P{lacW}CycAS004623 No P{lacW}CycAS010407 No P{lacW}CycAS024534 No P{lacW}CycAS052106 No P{lacW}CycAS052118 No P{lacW}CycAS052119 No P{lacW}CycAS054513 No P{lacW}CycAS132916 No P{lacW}CycAS144905 No P{lacW}CycAS144911 No P{lacW}CycAS144914 No P{lacW}l(3)SH052SH052 No P{PZ}CycA01545 No P{PZ}CycA01558 No P{PZ}CycA02461 No P{PZ}CycA03946 No P{PZ}CycA04335 No P{PZ}CycArO545 No insertion of mobile activating element P{EP}CycAG9446 NA P{EPgy2}CycAEY11746 NA miscellaneous insertions P{}CycAH116 NA P{BmΔ-w}CycAhari NA P{hsneo}CycA5 NA P{RS3}CycACB-5550-3 NA P{RS5}CycA5-HA-1817 NA P{ry11}CycAry40 NA PBac{PB}CycAc05304 NA PBac{PB}CycAc06568 NA PBac{PB}CycAc06664 NA insertion of enhancer trap binary system P{GawB}CycANP1609 No
Gene Ontology: Function, Process & Cellular Component ( 24 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein kinase regulator activity inferred from direct assay (Maldonado-Codina and Glover, 1992) protein binding inferred from physical interaction with Z600 (Gawlinski et al., 2007)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from mutant phenotype (Bhalerao et al., 2005) cellular process inferred from mutant phenotype (Boutros et al., 2004) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) mitosis inferred from mutant phenotype (Jacobs et al., 2001) mitotic sister chromatid segregation inferred from mutant phenotype (Parry and O'Farrell, 2001) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of chromatin binding inferred from genetic interaction with Orc2 (Baldinger and Gossen, 2009) regulation of exit from mitosis inferred from mutant phenotype (Reber et al., 2006) regulation of mitosis inferred from expression pattern (assigned by UniProtKB) (Lehner and O'Farrell, 1989) regulation of mitotic cell cycle, embryonic inferred from mutant phenotype (Reber et al., 2006) syncytial blastoderm mitotic cell cycle inferred from genetic interaction with CycB3, CycB (McCleland and O'Farrell, 2008)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Avedisov et al., 2000) inferred from direct assay (assigned by UniProtKB) (Lehner and O'Farrell, 1989) nucleus inferred from direct assay (Avedisov et al., 2000) inferred from direct assay (assigned by UniProtKB) (Lehner and O'Farrell, 1989)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein kinase regulator activity inferred from sequence or structural similarity with UniProtKB:P04962 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) non-traceable author statement (assigned by UniProtKB) (Lehner and O'Farrell, 1989) protein kinase binding inferred from electronic annotation with InterPro:IPR014400, InterPro:IPR015453 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
G2/M transition of mitotic cell cycle non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) mitosis traceable author statement (Su, 2001) negative regulation of mitotic metaphase/anaphase transition traceable author statement (Su, 2001) peripheral nervous system development traceable author statement (Salzberg et al., 1994) regulation of cyclin-dependent protein kinase activity inferred from electronic annotation with InterPro:IPR014400, InterPro:IPR015453 (FlyBase Curators et al., 2004-) regulation of G2/M transition of mitotic cell cycle inferred from electronic annotation with InterPro:IPR015453 (FlyBase Curators et al., 2004-) regulation of mitotic cell cycle, embryonic traceable author statement (Lee and Orr-Weaver, 2003)
Cellular Component
CV term Evidence References
fusome traceable author statement (Deng and Lin, 2001) nuclear cyclin-dependent protein kinase holoenzyme complex non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) spectrosome traceable author statement (Deng and Lin, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CycA allele Gene References CycA3 arm (Greaves et al., 1999) CycB (Knoblich and Lehner, 1993) dally (Nakato et al., 2002) rux (Thomas et al., 1994) CycA5 CycB (Ji et al., 2002) CycE (Secombe et al., 1998) dally (Nakato et al., 2002) rux (Gonczy et al., 1994, Thomas et al., 1994) wts (Tao et al., 1999) CycA01545 eff (Lilly et al., 2000) CycA03946 Tsc1 (Tapon et al., 2001) CycA04335 numb (Wai et al., 1999) CycAC8LR1 CycB (Ji et al., 2002) CycB3 (Jacobs et al., 1998) Rca1 (Grosskortenhaus and Sprenger, 2002) CycAhs.PK cdc2 (Sprenger et al., 1997) rux (Sprenger et al., 1997) CycAS.hs cdc2 (Sprenger et al., 1997, Parry and O'Farrell, 2001) CycAS(rux)3B rux (Dong et al., 1997) CycAScer\UAS.cHa cdc2 (Hayashi and Yamaguchi, 1999) CycAScer\UAS.T:Ivir\HA1 Rca1 (Grosskortenhaus and Sprenger, 2002) CycAScer\UAS.Δ170 rux (Foley and Sprenger, 2001) CycAunspecified mei-41 (Sibon et al., 1999) twin (Morris et al., 2005) CycAΔ.T:Ivir\HA1 bam (Lilly et al., 2000) unspecified CycB (Ruden and Jaeckle, 1995) gig (Tapon et al., 2001) os (Mukherjee et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64701 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000404 DroID - A comprehensive database of gene and protein interactions. • FBgn0000404 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39340
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24509 Dere\GG13881 Dgri\GH16723 Dmoj\GI13452 Dpse\GA19247 Dsec\GM24703 Dsim\GD12771 Dvir\GJ11813 Dwil\GK13671 Dyak\GE20173
Curated drosophilid orthologs	Dmau\CycA (Zeng et al., 2000) Dpse\GA19247   Dsim\CycA (Zeng et al., 2000)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000672-PA Aedes aegypti (mosquito) AGAP012413-PA Anopheles gambiae (mosquito) XP_623507.2 Apis mellifera (honey bee) XP_001942828.1 Acyrthosiphon pisum (pea aphid) At1g80370.1 Arabidopsis thaliana (wall cress) 15932 Batrachochytrium dendrobatidis (chytrid fungus) 69715 Branchiostoma floridae (lancelet) BGIBMGA001142-PA Bombyx mori (silk worm) ENSBTAP00000006503 Bos taurus (bovine) ENSBTAP00000009579 Bos taurus (bovine) CAL0004596 Candida albicans (a form of yeast) CN03476 Caenorhabditis brenneri (small nematode) CBP28013 Caenorhabditis briggsae (nematode) CE03820 Caenorhabditis elegans (worm) ENSCAFP00000006129 Canis familiaris (dog) CAGL0J08822g Candida glabrata (haploid yeast) ENSCINP00000017285 Ciona intestinalis (sea squirt) JA11648 Caenorhabditis japonica (nematode) CMI227C Cyanidioschyzon merolae (red alga) CPIJ013567 Culex pipens (mosquito) ENSCPOP00000009318 Cavia porcellus (guinea pig) 102457 Chlamidomonas reinhardtii (green alga) RP03239 Caenorhabditis remanei (nematode) RP14557 Caenorhabditis remanei (nematode) 176768 Capitella spl (polychaete worm) DEHA2E11198g Debaryomyces Hansenii (yeast) 216737 Daphnia pulex (daphnia) ENSDARP00000020968 Danio rerio (zebra fish) ENSECAP00000021863 Equus caballus (horse) XP_648667 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022010 Gymnopilus aculeatus (mushroom) ENSGALP00000027497 Gallus gallus (chicken) 116074 Hypsipyla robusta (cedar shoot borer) ENSP00000255465 Homo sapiens (human) 225111 Lottia gigantea (owl limpet) LmjF25.1470 Leishmania major (virus) ENSMODP00000012510 Monodelphis domestica (gray opossum) ENSMMUP00000001569 Macaca mulatta (rhesus monkey) ENSMUSP00000029270 Mus musculus (house mouse) 188880 Nematostella vectensis (starlet anemone) XP_001600970.1 Nasonia vitripennis (wasp) ENSOANP00000023802 Ornithorynchus anatinus (platypus) ENSORLP00000024918 Oryzias latipes (japanese killifish) LOC_Os12g31810.1 Oryza sativa (asian rice) PP04013 Pristionchus pacificus (nematode) 80110 Physcomitrella patens (moss) ENSPPYP00000006017 Pongo pygmaeus (orangutan) 548650 Populus trichocarpa (black cottonwood) ENSPTRP00000009850 Pan troglodytes (chimpanzee) ENSRNOP00000021156 Rattus norvegicus (norway rat) 4020570 Sorghum bicolor (sorghum) NP_999646.1 Strongylocentrotus purpuratus (purple sea urchin) 24944 Trichoplax adhaerens (metazoa) XP_972623.1 Tribolium castaneum (red flour beetle) Tc00.1047053506711.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509455.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016027 Tetraodon nigroviridis (green spotted pufferfish) 33883 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017356 Takifugu rubripes (pufferfish Takifugu) 16.m00500 Tetrahymena thermophila (ciliate protozoa) 96423.m00227 Trichomonas vaginalis (parasitic flagellated protozoan) 97121.m00175 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002219 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14248 LH16242 FBgn0237495 FBgn0215812 FBgn0215679 FBgn0199067 FBgn0184498 FBgn0179566 JGI_V11_216737 FBgn0079244 FBgn0158409 FBgn0158410 FBgn0136208 FBgn0124194 FBgn0106144 FBgn0101503 CPIJ013566 CPIJ013567 CPIJ005226 BGIBMGA001142 ACYPI002255 GB14847 AGAP012413 AAEL000672 PB20153 PHUM005940 GLEAN_07193
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	6633 w*; P{UAS-CycA.W}II.2 29313 y1 v1; P{TRiP.JF02472}attP2 31761 y1 v1; P{TRiP.HM04073}attP2 27983 y1 w*; P{EP}CycAG9446 6627 w*; CycAC8LR1/TM3, Sb1 P{35UZ}2 35694 y1 sc* v1; P{TRiP.GLV21059}attP2
Harvard	- PBac{PB}CycAc05304 - PBac{PB}CycAc06568
Kyoto	123684 w1118; P{RS3}CycACB-5550-3 125411 w1118; P{RS5}CycA5-HA-1817
VDRC	v103595 P{KK101548}VIE-260B v32421 w1118; P{GD8653}v32421
	More stocks available...
Genomic Clones ( 2 )
	BACR15K18 BACR48G03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 369 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32414 LD34144 LD44443 RE38818
Other clones	DPiM_LD44443
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16456 AT18381 AT29724 AT31333 GM01051 GM03849 GM05343 GM13787 LD03181 LD03236 LD03287 LD03363 LD03739 LD03989 LD04491 LD05252 LD06515 LD06948 LD07410 LD08277 LD09632 LD11035 LD11564 LD11694 LD13407 LD14456 LD14970 LD16633 LD20037 LD21085 LD27540 LD29082 LD29157 LD29850 LD30887 LD31903 LD32418 LD32735 LD35708 LD35872 LD36035 LD36236 LD38014 LD38271 LD38677 LD38692 LD40955 LD41259 LD41348 LD41355 LD42225 LD42535 LD43211 LD43481 LD43864 LD43920 LD46210 LD46241 LD46249 LD47092 LD47161 LD47349 LP06942 LP24353 RE02560 RE02727 RE03004 RE04851 RE05404 RE06565 RE07062 RE08273 RE10794 RE11038 RE11406 RE12674 RE15374 RE18192 RE19155 RE20320 RE24496 RE32519 RE32914 RE35480 RE36233 RE43926 RE45504 RE49116 RE54812 RE56108 RE56410 RE58054 RE63014 RE64370 RE65759 RE66959 RE67323 RE67536 RE68933 RE69652 RE70454 RE70715 RE70778 RE70781 RE71557 RE71929 RE73048 RE74324 SD04533 SD05064 SD05076 SD05088 SD07321 SD09039 SD09201 SD17505 SD17568
Other clones	1879 63236 102336 102879 105675 107827 124646 146555 147197 148267 159074 160800 162783 163922 193050 214351.48 274325 276732 bs73e12 CK01.54C.E10 CK01.94A.F12 CK01.146A.F9 Dmel_dig_001373_0647_2311 Dmel_dig_002535_0613_3621 Dmel_dig_003478_0641_0408 Dmel_dig_013018_0672_2785 Dmel_dig_014942_0594_2689 Dmel_dig_020142_0650_3499 Dmel_neb_007491_0925_0410 Dmel_neb_008640_0689_1595 Dmel_neb_010056_0450_1007 Dmel_neb_010795_0944_1885 Dmel_neb_012695_0631_0832 Dmel_neb_013009_0663_1005 Dmel_neb_015340_0672_0457 EC051797 EK044349 EK073354 EK096107 EK120021 EK123051 EK125917 EK188833 EK206828 EK207614 EK224531 EK234114 EK243931 EK247050 EK249863 EK250540 EK253512 EK262347 EK266510 EK268849 EK295914 EK301938 EK303419 EP11259 FGM206B07 LD02179 LD05494 LD05619 LD06357 LD06560 LD07164 LD13696 LD14666 LD15035 LD17431 LD20040 LD20795 LD41886 RE02469 RE02754 RE02975 RE03131 RE05381 RE05384 RE06313 RE06542 RE07580 RE07664 RE07908 RE09106 RE11784 RE12615 RE15184 RE15436 RE16523 RE18348 RE19243 RE19311 RE24148 RE25988 RE26104 RE26106 RE29531 RE29565 RE31286 RE31514 RE34141 RE34922 RE35046 RE36390 RE36958 RE37523 RE37985 RE38661 RE39701 RE40647 RE44681 RE45424 RE46217 RE47725 RE48053 RE49661 RE50549 RE50556 RE50562 RE51715 RE53911 RE54141 RE54594 RE58588 RE62438 RE66016 RE66575 RE67132 RE68481 RE72150 RE73292 RP003001101 RP003003146 RP003006409 RP003010775 RP003019116 RP003041664 RP003044124 RP003045595 RP003045751 RP003056135 RP003062885 RP003068787 RP003068949 RP003077920 RP003080017 RP003088327 RP003096877 RP003099534 RP003112630 RP003120370 RP003130841 RP003136718 RP003147832 RP003149813 RP003176128 RP003176832 RP003178019 RP003179705 RP003187993 RP003197957 RP003202665 RP003210455 RP003210957 RP003221671 RP003229105 RP003231874 RP003235748 RP003244127 RP003244867 RP003244912 RP003247966 RP003260747 RP003262241 RP003262646 RP003273914 RP003273934 RP003280824 RP003285540 RP003291298 RP003297872 RP003301354 RP003320708 RP003325638 RP003328365 RP003334382 RP003342440 RP003355636 RP003355896 RP003358644 RP003360654 RP003362354 RP003363790 RP003367533 RP003368198 RP003378198 RP003390955 RP003397524 RP003398778 RP003398948 RP003408147 RP003412092 RP003420322 RP003423750 RP003423883 RP003434733 RP003437188 RP003437586 RP003439742 RP003450458 RP003455218 RP003469623 RP003472291 RP003473991 RP003476673 RP003483503 RP003483509 RP003495204 RP003508522 RP003518653 RP003522022 RP003528338 RP003532806 RP003535388 RP003540067 RP003548782 RP003557174 RP003559424 RP003562454 RP003563004 RP003564814 RP003568570 RP003570827 RP003585773 RP003610216 RP003619362 RP003644796 RP003646037 RP003649354 RP003658158 RP003659496 RP003659912 RP003672366 RP003678547 UT01636 UUGC1034
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000404 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39340
Antibody Information
	polyclonal (Whitfield et al., 1990, Lehner and O'Farrell, 1989)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CycA CG5940 (Zhang, 1999.11)
Source for database merge of	Source for merge of: CycA anon-WO0140519.128 (FlyBase, 1996-)
Additional comments	Source for merge of CycA anon-WO0140519.128 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	The CycA protein inhibits the premature degradation of mitotic cyclins and stg protein by negatively regulating the rap protein. (Reber et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) CycA is required for entry into mitosis. (Jacobs et al., 2001) The presence of the N terminal region is not required for CycAs function in mitotic entry. (Jacobs et al., 2001) CycA degradation facilitates chromosome disjunction. (Parry and O'Farrell, 2001) Two EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Candidate gene for tibia length quantitative trait locus. (Macdonald and Goldstein, 1999) Candidate gene for quantitative trait (QTL) locus determining bristle number. (Nuzhdin et al., 1999) CycA regulates the nuclear changes while CycB regulates cytoskeletal changes in syncytial preblastoderm embryos. (Stiffler et al., 1999) A balance of CycA and CycB proteins seems necessary for proper coordination during the embryonic cycles. (Stiffler et al., 1999) numb functions downstream of cell division genes (CycA, Rca1 and stg) and progression through the cell cycle is required for asymmetric localisation of numb and thus N mediated specification of the sib fate in the RP2/sib division. (Wai et al., 1999) The loss of CycA, Rca1 or stg leads to a block in the division of GMC-1, however this GMC-1 adopts a RP2 identity. (Wai et al., 1999) Double and triple mutant analyses show that CycB3, CycB and CycA cooperate during mitosis. (Jacobs et al., 1998) Rca1 positively regulates CycA by modulating CycA protein levels. (Dong et al., 1997) CycA is misexpressed in the PNS of da mutant embryos. (Hassan and Vaessin, 1997) CycA protein can drive the G1/S transition in embryos, but this function is suppressed by three types of control: destruction of CycA protein, inhibitory phosphorylation of cdc2 and inhibition by rux. (Sprenger et al., 1997) Ectopic rux converts the mitotic cycle into an endoreplication cycle by down-regulating CycA-associated kinase activity. (Thomas et al., 1997) Cloning and sequencing of CycA reveals a sequence identical to DRE (DNA replication-related element) in the region of nucleotide positions -71 to -64 with respect to the transcription initiation site. The role of the DRE in promoter activity is studied and results indicate CycA is under the control of the DRE/Dref system. (Ohno et al., 1996) Heterozygosity for CycA is not sufficient for females to produce viable homozygous kni mutant progeny. Double heterozygotes for CycA and CycB increase the efficiency for kni mutant rescue suggesting the cyclins interact synergistically. (Ruden and Jaeckle, 1995) Observations in CycA mutants implicate G2 cyclins in reinitiation of DNA replication during the G2 phase of the mitotic cell cycle. (Sauer et al., 1995) Comparison of the fzy mutant phenotype with the phenotype resulting from expression of N-terminal truncated CycA, CycB or CycB3 suggests that fzy is not required for mitotic cyclin degradation alone, because fzy mutations, but not truncated cyclins, block chromosome separation. (Sigrist et al., 1995) rux acts genetically to negatively regulate CycA. (Thomas et al., 1995) During development, changing levels of cell cycle regulators alters the rate limiting step and the mechanism governing progress of the cell cycle. (Edgar et al., 1994) Mutation in CycA affects cell division in the neuronal lineage. (Salzberg et al., 1994) CycA is required for PNS development in the embryo. (Salzberg et al., 1994) CycA transcripts injected into the syncytial blastoderm do not become incorporated to the pole cells, as CycB transcripts do. (Dalby and Glover, 1993) The CycA product has a mitotic function and acts synergistically with CycB during the G2-M transition. (Knoblich and Lehner, 1993) As part of an investigation into the effects of 37oC heat shock on G2-phase cycle 14 embryos, the degradation of cyclin A and cyclin B in the resulting synchronised mitotic domains was shown to be delayed. (Maldonado-Codina et al., 1993) CycA gene product is not required for the continued rounds of DNA replication in the ventral cord or in endoreplicating tissues during embryonic development. (Smith et al., 1993) A functional CycA gene is required for continued cell division after exhaustion of maternally provided cyclin A. (Lindsley and Zimm, 1992) Maternal message uniformly distributed in newly laid egg, but becomes more concentrated in the cortex prior to peripheral nuclear migration. At the time of cellularization of the blastoderm, zygotic message is produced. Cyclin A accumulates in the interphase cytoplasm of cellularized embryos, but relocates to the nuclear region early in prophase and is completely degraded during metaphase. Message confined to dividing tissues in brain and imaginal discs in larvae. (Lindsley and Zimm, 1992) CycA and CycB are coexpressed in all proliferating cells throughout development. (Lehner and O'Farrell, 1990) CycA has a role in the G2 to M transition, independent of spindle formation. (Whitfield et al., 1990) CycA is required for cell cycle progression. (Lehner and O'Farrell, 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079306 NM_168483 RefSeq (Proteins) • NP_524030 NP_729756 DDBJ / EMBL / GenBank • AAA28435 AAF49999 AAF50000 AAL13941 AAN71390 AI512541 AW943723 AX154779 AY058712 BAA01628 BAA01629 BI241691 BT001635 CL868508 CZ470816 CZ470904 D10856 D10857 D10858 G00572 G00718 G01162 M24841 Entrez Gene - A searchable database of RefSeq genes. • 39340 UniProtKB/Swiss-Prot • P14785
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclin, C-terminal (IPR004367) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763) Cyclin A/B/D/E (IPR014400) Cyclin A, G2/mitotic-specific (IPR015453)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64701 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000404 DroID - A comprehensive database of gene and protein interactions. • FBgn0000404 DRSC - Results from RNAi screens. • FBgn0000404 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5940-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000404 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39340 InParanoid A subset of ortholog calls from InParanoid. • AAEL000672-PA Aedes aegypti (mosquito) AGAP012413-PA Anopheles gambiae (mosquito) XP_623507.2 Apis mellifera (honey bee) XP_001942828.1 Acyrthosiphon pisum (pea aphid) At1g80370.1 Arabidopsis thaliana (wall cress) 15932 Batrachochytrium dendrobatidis (chytrid fungus) 69715 Branchiostoma floridae (lancelet) BGIBMGA001142-PA Bombyx mori (silk worm) ENSBTAP00000006503 Bos taurus (bovine) ENSBTAP00000009579 Bos taurus (bovine) CAL0004596 Candida albicans (a form of yeast) CN03476 Caenorhabditis brenneri (small nematode) CBP28013 Caenorhabditis briggsae (nematode) CE03820 Caenorhabditis elegans (worm) ENSCAFP00000006129 Canis familiaris (dog) CAGL0J08822g Candida glabrata (haploid yeast) ENSCINP00000017285 Ciona intestinalis (sea squirt) JA11648 Caenorhabditis japonica (nematode) CMI227C Cyanidioschyzon merolae (red alga) CPIJ013567 Culex pipens (mosquito) ENSCPOP00000009318 Cavia porcellus (guinea pig) 102457 Chlamidomonas reinhardtii (green alga) RP03239 Caenorhabditis remanei (nematode) RP14557 Caenorhabditis remanei (nematode) 176768 Capitella spl (polychaete worm) DEHA2E11198g Debaryomyces Hansenii (yeast) 216737 Daphnia pulex (daphnia) ENSDARP00000020968 Danio rerio (zebra fish) ENSECAP00000021863 Equus caballus (horse) XP_648667 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022010 Gymnopilus aculeatus (mushroom) ENSGALP00000027497 Gallus gallus (chicken) 116074 Hypsipyla robusta (cedar shoot borer) ENSP00000255465 Homo sapiens (human) 225111 Lottia gigantea (owl limpet) LmjF25.1470 Leishmania major (virus) ENSMODP00000012510 Monodelphis domestica (gray opossum) ENSMMUP00000001569 Macaca mulatta (rhesus monkey) ENSMUSP00000029270 Mus musculus (house mouse) 188880 Nematostella vectensis (starlet anemone) XP_001600970.1 Nasonia vitripennis (wasp) ENSOANP00000023802 Ornithorynchus anatinus (platypus) ENSORLP00000024918 Oryzias latipes (japanese killifish) LOC_Os12g31810.1 Oryza sativa (asian rice) PP04013 Pristionchus pacificus (nematode) 80110 Physcomitrella patens (moss) ENSPPYP00000006017 Pongo pygmaeus (orangutan) 548650 Populus trichocarpa (black cottonwood) ENSPTRP00000009850 Pan troglodytes (chimpanzee) ENSRNOP00000021156 Rattus norvegicus (norway rat) 4020570 Sorghum bicolor (sorghum) NP_999646.1 Strongylocentrotus purpuratus (purple sea urchin) 24944 Trichoplax adhaerens (metazoa) XP_972623.1 Tribolium castaneum (red flour beetle) Tc00.1047053506711.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509455.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016027 Tetraodon nigroviridis (green spotted pufferfish) 33883 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017356 Takifugu rubripes (pufferfish Takifugu) 16.m00500 Tetrahymena thermophila (ciliate protozoa) 96423.m00227 Trichomonas vaginalis (parasitic flagellated protozoan) 97121.m00175 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002219 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/cyclina1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39340 modMine - Data generated by the modENCODE project. • FBgn0000404 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14248 LH16242 FBgn0237495 FBgn0215812 FBgn0215679 FBgn0199067 FBgn0184498 FBgn0179566 JGI_V11_216737 FBgn0079244 FBgn0158409 FBgn0158410 FBgn0136208 FBgn0124194 FBgn0106144 FBgn0101503 CPIJ013566 CPIJ013567 CPIJ005226 BGIBMGA001142 ACYPI002255 GB14847 AGAP012413 AAEL000672 PB20153 PHUM005940 GLEAN_07193
Synonyms & Secondary IDs ( 32 )
Reported As
Symbol Synonym	0033/02 (Deak et al., 1997) 0040/24 (Deak et al., 1997) 0046/23 (Deak et al., 1997) 0104/07 (Deak et al., 1997) 0245/34 (Deak et al., 1997) 0521/06 (Deak et al., 1997) 0545/13 (Deak et al., 1997) 1329/16 (Deak et al., 1997) 1449/05 (Deak et al., 1997) anon-WO0140519.128   CG5940 (Keleman et al., 2009.8.5, Haussmann et al., 2008, Perkins et al., 2009, Ni et al., 2008, Ni et al., 2011.7.19) CLD3 (Erhardt et al., 2008) cycA (Morris et al., 2005, Ayyar et al., 2003, Nakato et al., 2002, Grosskortenhaus and Sprenger, 2002, Ji et al., 2002, Beitel and Krasnow, 2000, Akiyama-Oda et al., 2000, Myster and Duronio, 2000, Li and Vaessin, 2000, Greaves et al., 1999, Lear et al., 1999, Wai et al., 1999, Truong et al., 1999, Salzberg et al., 1997, Sweeney et al., 1997, Dong et al., 1997, Salzberg and Bellen, 1996, Hassan and Vassin, 1996, Salzberg et al., 1994, Sauer et al., 1995, Thomas et al., 1994, Edgar et al., 1994, Foe et al., 1993, McEllin et al., 2006, Park et al., 2003, Chen et al., 2005, McClure and Schubiger, 2008, Orian et al., 2007, Kwon et al., 2009, Chen et al., 2009, Heriche et al., 2003, Scaria et al., 2008, Silies and Klämbt, 2010) CycA (Jones et al., 2006, Tanaka-Matakatsu et al., 2007, Sanchez-Elsner et al., 2006, Mukherjee et al., 2006, Richter et al., 2011, Großhans et al., 2007, Friedman and Perrimon, 2006, Sandmann et al., 2007, LaRocque et al., 2007, Pfleger et al., 2007, Shimizu et al., 2008, Jordan et al., 2006, Huang and Raff, 2002, Swan and Schupbach, 2007, LaRocque et al., 2007, Vrailas and Moses, 2006, Sugimura and Lilly, 2006, Lecuyer et al., 2007, Kugler and Nagel, 2007, Minakhina et al., 2007, Franklin-Dumont et al., 2007, Kankel et al., 2007, Johnson et al., 2007, Bakal et al., 2008, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Sun and Deng, 2007, Bowman et al., 2008, Lee et al., 2008, Sato et al., 2008, Caussinus et al., 2008, McCleland et al., 2009, Escudero and Freeman, 2007, Peng and Karpen, 2009, Benoit et al., 2008, Zielke et al., 2006, Gawlinski et al., 2007, O'Farrell and Kylsten, 2008, Althoff et al., 2009, Leismann and Lehner, 2003, Greene et al., 2005, Tanaka-Matakatsu et al., 2007, Shyu et al., 2009, Baonza and Freeman, 2005, Khurana et al., 2006, Morris et al., 2006, Magalhaes et al., 2007, Gawlinski et al., 2007, Beck et al., 2010, Li et al., 2010, Beam and Moberg, 2010, zur Lage and Jarman, 2010, Beltran et al., 2007, Tastan et al., 2010, Poulton et al., 2011, Gilbert et al., 2011, Monk et al., 2010) CYCA (Erhardt et al., 2008) Cyc A (McCleland and O'Farrell, 2008) DmcycA (Zraly et al., 2004, Horb and Horb, 2010) hari   l(3)68Ea   l(3)183 (Huang and Fischer-Vize, 1996) l(3)03946   l(3)j3C8   l(3)neo114   l(3)rsg11   rsg11 (Hoogwerf et al., 1988, ) S(rux)3B (Dong et al., 1997)
Name Synonym	cyclin A (Findlay et al., 2005, Lee and Orr-Weaver, 2003, Nagao and Yanagida, 2002, O'Farrell, 2001, Douglas and Haddad, 2003, Purdy and Su, 2003, Fung et al., 2002, Deng and Lin, 2001, Mahowald, 2001, Jaklevic et al., 2000, Harper and Elledge, 1998, de Cuevas et al., 1997, Su and O'Farrell, 1997, Sigrist et al., 1995, Lilly et al., 2000, Wodarz and Gonzalez, 2006, Kaplow et al., 2007, Huang et al., 2007, Maurange et al., 2006, Sakaguchi and Steward, 2007, Shimizu et al., 2008, Huang and Raff, 2002, Muller and Kassis, 2006, Mihaylov et al., 2002, Chen et al., 2005, McClure and Schubiger, 2008, Ringrose and Paro, 2007, Chia et al., 2008, Frolov et al., 2005, Hyun et al., 2005, Tadros et al., 2007, Erhardt et al., 2008, Lee et al., 2008, Lopes et al., 2005, González et al., 2008, Huang et al., 2007, Pal et al., 2007, Benoit et al., 2009, Vardy et al., 2009, Baldinger and Gossen, 2009, McCleland and O'Farrell, 2008, Chen et al., 2009, Anderson et al., 2009, Tanaka-Matakatsu et al., 2007, Shyu et al., 2009, Brunk et al., 2007, Baonza and Freeman, 2005, Oliveira et al., 2010, Horb and Horb, 2010, Kotadia et al., 2008, Nieduszynski et al., 2002, Andersen et al., 2010) CyclinA (Skeath and Thor, 2003, Mukherjee et al., 2006, Bowman et al., 2008, Choksi et al., 2006, Beck et al., 2010) Cyclin A (Pines, 2006, Franklin-Dumont et al., 2007, Vrailas et al., 2006, Reber et al., 2006, Thomas, 2005, Furukawa et al., 2003, Pfleger et al., 2007, Garcia et al., 2007, Silva et al., 2006, Mandal et al., 2005, Takada et al., 2007, O'Keefe et al., 2011, Swan and Schupbach, 2007, Vrailas and Moses, 2006, Kugler and Nagel, 2007, Zhu et al., 2008, Pesin and Orr-Weaver, 2007, Franklin-Dumont et al., 2007, Kankel et al., 2007, Sun and Deng, 2007, Narbonne-Reveau et al., 2008, Benoit et al., 2008, Zielke et al., 2008, Caussinus et al., 2008, Rickmyre et al., 2007, Escudero and Freeman, 2007, Sukhanova and Du, 2008, Zielke et al., 2006, Althoff et al., 2009, Merkle et al., 2009, Scaria et al., 2008, Baonza and Freeman, 2005, Khurana et al., 2006, Li et al., 2010, zur Lage and Jarman, 2010, Beam and Moberg, 2010, Papoulas et al., 2010, Poulton et al., 2011, Gilbert et al., 2011, Monk et al., 2010) cyclinA (Somma et al., 2008, Silies and Klämbt, 2010) rose-gespleten region interval 11 (Hoogwerf et al., 1988) Suppressor of rux 3B (Dong et al., 1997)
Secondary FlyBase IDs
	FBgn0010826 FBgn0011353 FBgn0044754
References ( 428 )
Generate a list of	All references relating to this gene ( 428 )
List References by type	Research paper  ( 274 ) Supplementary material  ( 7 ) Review  ( 55 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 62 ) FlyBase analysis  ( 3 ) Conference report  ( 2 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Computer file  ( 5 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 17 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Chen et al., 2011, Development 138(12): 2441--2450 Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. [FBrf0213772] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] O'Keefe et al., 2011, Mech. Dev. 128(1-2): 59--70 EndoGI modulates Notch signaling and axon guidance in Drosophila. [FBrf0213012] Poulton et al., 2011, Development 138(9): 1737--1745 The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. [FBrf0213494] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. [FBrf0211794] Beam and Moberg, 2010, Fly 4(2): 104--116 The gang of four gene regulates growth and patterning of the developing Drosophila eye. [FBrf0211089] Beck et al., 2010, Dev. Biol. 339(2): 320--328 Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint. [FBrf0210114] Horb and Horb, 2010, Dev. Biol. 345(2): 156--169 BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. [FBrf0211643] Li et al., 2010, Genes Dev. 24(9): 933--946 Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. [FBrf0210675] Monk et al., 2010, Cell Stem Cell 6(4): 348--360 HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions. [FBrf0210446] Oliveira et al., 2010, Nat. Cell Biol. 12(2): 185--192 Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. [FBrf0209876] Papoulas et al., 2010, Development 137(24): 4201--4209 dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. [FBrf0212321] Silies and Klämbt, 2010, Nat. Neurosci. 13(11): 1357--1364 APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. [FBrf0212144] Tastan et al., 2010, Development 137(19): 3167--3176 Drosophila Ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts. [FBrf0211752] zur Lage and Jarman, 2010, BMC Dev. Biol. 10: 34 The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. [FBrf0210540] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...