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Gene Dmel\Cyt-b5-r

General Information
Symbol	Dmel\Cyt-b5-r	Species	D. melanogaster
Name	Cytochrome b5-related	Annotation symbol	CG13279
Feature type	protein_coding_gene	FlyBase ID	FBgn0000406
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Cyt-b5, TU-36B
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36B1-36B1	Sequence location	2L:16,788,774..16,790,721 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cytochrome b5-related is referred to in FlyBase by the symbol Dmel\Cyt-b5-r (CG13279, FBgn0000406). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; fatty acid biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cytochrome b5, heme-binding site; Cytochrome b5-like heme/steroid binding domain; Fatty acid desaturase, type 1; Fatty acid/sphingolipid desaturase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval midgut, larval/adult hindgut, adult Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1632623_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cyt-b5-r. Gene sequence location is 2L:16788774..16790721.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Cyt-b: Cytochrome-b homologue Encodes a cytochrome-b homologue that is expressed specifically in muscles; expression is concordant with that of Mhc.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36B1-36B1   Limits computationally determined from genome sequence between P{lacW}Mhck10423&P{lacW}Cask03902 and P{lacW}Aac11k06710
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36B-36B   (determined by in situ hybridisation)   (Levin et al., 1989)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyt-b5-r for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyt-b5-r-RA FBtr0080932  NM_057806   1465   436 Cyt-b5-r-RB FBtr0331931  NM_001273585   1557   436
Additional Transcript Data & Comments
Reported size (kB)	1.6 (northern blot) (Levin et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyt-b5-r-PA   FBpp0080486   50.4   436   8.25     NP_477154   AAF53567 Cyt-b5-r-PB   FBpp0304264   50.4   436   8.25     NP_001260514   AGB93049
Additional Polypeptide Data & Comments
Reported size (kDa)	414 (aa); 47 (kD) (Levin et al., 1989)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b5, heme-binding site (IPR018506) Cytochrome b5-like heme/steroid binding domain (IPR001199) Fatty acid desaturase, type 1 (IPR005804) Fatty acid/sphingolipid desaturase (IPR012171)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567327   AA567353   AA697354   AA697654   AA698378   AA698562   AA698908   AE014134 AAF53567   AC005119   AC093097   AE014134 AGB93049   AI062964   AI063072   AI063229   AI063261   AI063726   AI063992   AI064450   AI107377   AI107418   AI107466   AI107621   AI107955   AI108290   AI108744   AI108908   AI109561   AI110173   AI113961   AI114194   AI134607   AI135252   AI238580   AI257038   AI292473   AI292494   AI292617   AI293054   AI293239   AI386607   AI386678   AI387284   AI387740   AI387956   AI387982   AI389048   AI389175   AI389270   AI389630   AI402836   AI403622   AI403781   AI403794   AI403798   AI404332   AI404633   AI404818   AI404978   AI406256   AI513763   AI514158   AI514223   AI517078   AI517737   AW940138   AY058287 AAL13516   BI167352   BI168562   BI214124   BI237289   BI238271   BI374379   BI566796   BI567575   BI575119   BI580666   BI580758   BI586602   BI588460   CO269502   CO330722   EC061549   EC063809   EC216346   EC243116   EL871015   EL873955   EL873956   EL874318   EL882288   EV574848   EV575912   EV579774   EV581765   EV598662   GH741394   GH742286   GH743150   GH768318   X15008 CAA33113
UniProtKB/Swiss-Prot	P19967
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) procrystal cell   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 16   embryonic/larval somatic muscle   (Levin et al., 1989) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   embryonic/larval visceral muscle   (Levin et al., 1989) larval stage & adult stage     (Levin et al., 1989) pupal stage | late   skeletal muscle of leg   (Levin et al., 1989) tergosternal muscle   (Levin et al., 1989)
Additional Descriptive Data
	Cyt-b5 transcripts are detected in late embryonic and pupal RNAs on northern blots. They are detected predominantly in muscles by in situ hybridization. Specifically, they are found in somatic and visceral muscles in late embryos and in indirect flight muscles, tergosternal muscles, abdominal ventral muscles, and leg muscles in late pupae. Mhc transcripts are also found in these tissues. (Levin et al., 1989)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) mitochondrion inferred from direct assay (Kula and Rozek, 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval midgut, larval/adult hindgut, adult Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules    654.3 Larval Fat Body    1007.1 Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head    2635.3 Adult Eye    1981.175 Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body    5125.6 Adult Salivary Gland    20.3 Adult Heart    4124.85 Adult VirginFemale Spermatheca    5086.7 Adult InseminatedFemale Spermatheca    4644.7 Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass    4043.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules  (654.3) Larval Fat Body  (1007.1) Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head  (2635.3) Adult Eye  (1981.175) Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body  (5125.6) Adult Salivary Gland    20.3 Adult Heart  (4124.85) Adult VirginFemale Spermatheca  (5086.7) Adult InseminatedFemale Spermatheca  (4644.7) Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass  (4043.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules    654.3 Larval Fat Body  1007.1 Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head  (2635.3) Adult Eye  (1981.175) Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body  (5125.6) Adult Salivary Gland    20.3 Adult Heart  (4124.85) Adult VirginFemale Spermatheca  (5086.7) Adult InseminatedFemale Spermatheca  (4644.7) Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass  (4043.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules    654.3 Larval Fat Body    1007.1 Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head    2635.3 Adult Eye    1981.175 Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body    5125.6 Adult Salivary Gland    20.3 Adult Heart    4124.85 Adult VirginFemale Spermatheca    5086.7 Adult InseminatedFemale Spermatheca    4644.7 Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass    4043.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules    654.3 Larval Fat Body    1007.1 Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head    2635.3 Adult Eye    1981.175 Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body    5125.6 Adult Salivary Gland    20.3 Adult Heart    4124.85 Adult VirginFemale Spermatheca    5086.7 Adult InseminatedFemale Spermatheca    4644.7 Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass    4043.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules  654.3 Larval Fat Body  (1007.1) Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head  (2635.3) Adult Eye  (1981.175) Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body  (5125.6) Adult Salivary Gland    20.3 Adult Heart  (4124.85) Adult VirginFemale Spermatheca  (5086.7) Adult InseminatedFemale Spermatheca  (4644.7) Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass  (4043.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules    654.3 Larval Fat Body  1007.1 Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head  (2635.3) Adult Eye  (1981.175) Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body  (5125.6) Adult Salivary Gland    20.3 Adult Heart  (4124.85) Adult VirginFemale Spermatheca  (5086.7) Adult InseminatedFemale Spermatheca  (4644.7) Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass  (4043.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.125 Larval Midgut    406.2 Larval Hindgut    172.1 Larval Malpighian Tubules    654.3 Larval Fat Body    1007.1 Larval Salivary Gland    31.6 Larval Trachea    49.825 Larval Carcass    24 Adult Head    2635.3 Adult Eye    1981.175 Adult Brain    146 Adult Thoracic-Abdominal Ganglion    123.3 Adult Crop    64.2 Adult Midgut    41.8 Adult Hindgut    441.3 Adult Malpighian Tubules    242.7 Adult Fat Body    5125.6 Adult Salivary Gland    20.3 Adult Heart    4124.85 Adult VirginFemale Spermatheca    5086.7 Adult InseminatedFemale Spermatheca    4644.7 Adult Ovary    4.1 Adult Testis    7.1 Adult Male Accessory Gland    3.2 Adult Carcass    4043.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2635.3   NA  Eye    1981.175   NA  Brain    146   1.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    123.3   NA  Crop    64.2   406.2  Midgut    41.8   172.1  Hindgut    441.3   654.3  Malpighian Tubules    242.7   1007.1  Fat Body    5125.6   31.6  Salivary Gland    no informative data   NA  Heart    4124.85   49.825  Trachea    NA   NA  VirginFemale Spermatheca    5086.7   NA  InseminatedFemale Spermatheca    4644.7   NA  Ovary    4.1   NA  Testis    7.1   NA  Male Accessory Gland    3.2   no informative data  Carcass    4043.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    223 head, virgin 4-day female    313 head, virgin 20-day female    729 head, mated 1-day female    162 head, mated 4-day female    282 head, mated 20-day female    460 head, mated 1-day male    194 head, mated 4-day male    302 head, mated 20-day male    589 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    128 fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    153 carcass, 4-day adult    198 carcass, 20-day adult    326 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (223) head, virgin 4-day female  (313) head, virgin 20-day female  (729) head, mated 1-day female  (162) head, mated 4-day female  (282) head, mated 20-day female  (460) head, mated 1-day male  (194) head, mated 4-day male  (302) head, mated 20-day male  (589) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering  (128) fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult  (153) carcass, 4-day adult  (198) carcass, 20-day adult  (326) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (223) head, virgin 4-day female  (313) head, virgin 20-day female  (729) head, mated 1-day female  (162) head, mated 4-day female  (282) head, mated 20-day female  (460) head, mated 1-day male  (194) head, mated 4-day male  (302) head, mated 20-day male  (589) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering  (128) fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult  (153) carcass, 4-day adult  (198) carcass, 20-day adult  (326) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    223 head, virgin 4-day female    313 head, virgin 20-day female    729 head, mated 1-day female    162 head, mated 4-day female    282 head, mated 20-day female    460 head, mated 1-day male    194 head, mated 4-day male    302 head, mated 20-day male    589 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    128 fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    153 carcass, 4-day adult    198 carcass, 20-day adult    326 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    223 head, virgin 4-day female    313 head, virgin 20-day female    729 head, mated 1-day female    162 head, mated 4-day female    282 head, mated 20-day female    460 head, mated 1-day male    194 head, mated 4-day male    302 head, mated 20-day male    589 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    128 fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    153 carcass, 4-day adult    198 carcass, 20-day adult    326 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (223) head, virgin 4-day female  (313) head, virgin 20-day female  (729) head, mated 1-day female  (162) head, mated 4-day female  (282) head, mated 20-day female  (460) head, mated 1-day male  (194) head, mated 4-day male  (302) head, mated 20-day male  (589) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering  (128) fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult  (153) carcass, 4-day adult  (198) carcass, 20-day adult  (326) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (223) head, virgin 4-day female  (313) head, virgin 20-day female  (729) head, mated 1-day female  (162) head, mated 4-day female  (282) head, mated 20-day female  (460) head, mated 1-day male  (194) head, mated 4-day male  (302) head, mated 20-day male  (589) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering  128 fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult  (153) carcass, 4-day adult  (198) carcass, 20-day adult  (326) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    223 head, virgin 4-day female    313 head, virgin 20-day female    729 head, mated 1-day female    162 head, mated 4-day female    282 head, mated 20-day female    460 head, mated 1-day male    194 head, mated 4-day male    302 head, mated 20-day male    589 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    15 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    128 fat body, white prepupae    19 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    153 carcass, 4-day adult    198 carcass, 20-day adult    326 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr    41 embryo 06-08hr    94 embryo 08-10hr    81 embryo 10-12hr    28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    48 embryo 20-22hr    73 embryo 22-24hr    120 larva L1    519 larva L2    497 larva L3 12hr old    769 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    18 white prepupae new    30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day    277 adult male 05day    169 adult male 30day    131 adult female 01day    137 adult female 05day    94 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr  (41) embryo 06-08hr  (94) embryo 08-10hr  (81) embryo 10-12hr  (28) embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr  (44) embryo 18-20hr  (48) embryo 20-22hr  (73) embryo 22-24hr  (120) larva L1  (519) larva L2  (497) larva L3 12hr old  (769) larva L3 puffstage 1-2  (165) larva L3 puffstage 3-6  (56) larva L3 puffstage 7-9    18 white prepupae new  (30) white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day  (277) adult male 05day  (169) adult male 30day  (131) adult female 01day  (137) adult female 05day  (94) adult female 30day  (85) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr    41 embryo 06-08hr    94 embryo 08-10hr    81 embryo 10-12hr    28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    48 embryo 20-22hr    73 embryo 22-24hr  (120) larva L1  (519) larva L2  (497) larva L3 12hr old  (769) larva L3 puffstage 1-2  (165) larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    18 white prepupae new    30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day  (277) adult male 05day  (169) adult male 30day  (131) adult female 01day  (137) adult female 05day    94 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr    41 embryo 06-08hr    94 embryo 08-10hr    81 embryo 10-12hr    28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    48 embryo 20-22hr    73 embryo 22-24hr    120 larva L1    519 larva L2    497 larva L3 12hr old    769 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    18 white prepupae new    30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day    277 adult male 05day    169 adult male 30day    131 adult female 01day    137 adult female 05day    94 adult female 30day    85 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr    41 embryo 06-08hr    94 embryo 08-10hr    81 embryo 10-12hr    28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    48 embryo 20-22hr    73 embryo 22-24hr    120 larva L1    519 larva L2    497 larva L3 12hr old    769 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    18 white prepupae new    30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day    277 adult male 05day    169 adult male 30day    131 adult female 01day    137 adult female 05day    94 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr  (41) embryo 06-08hr  (94) embryo 08-10hr  (81) embryo 10-12hr  28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr  (44) embryo 18-20hr  (48) embryo 20-22hr  (73) embryo 22-24hr  (120) larva L1  (519) larva L2  (497) larva L3 12hr old  (769) larva L3 puffstage 1-2  (165) larva L3 puffstage 3-6  (56) larva L3 puffstage 7-9    18 white prepupae new  30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day  (277) adult male 05day  (169) adult male 30day  (131) adult female 01day  (137) adult female 05day  (94) adult female 30day  (85) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr    41 embryo 06-08hr    94 embryo 08-10hr    81 embryo 10-12hr    28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    48 embryo 20-22hr    73 embryo 22-24hr  120 larva L1  (519) larva L2  (497) larva L3 12hr old  (769) larva L3 puffstage 1-2  (165) larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    18 white prepupae new    30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day  (277) adult male 05day  (169) adult male 30day  131 adult female 01day  137 adult female 05day    94 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    8 embryo 04-06hr    41 embryo 06-08hr    94 embryo 08-10hr    81 embryo 10-12hr    28 embryo 12-14hr    13 embryo 14-16hr    20 embryo 16-18hr    44 embryo 18-20hr    48 embryo 20-22hr    73 embryo 22-24hr    120 larva L1    519 larva L2    497 larva L3 12hr old    769 larva L3 puffstage 1-2    165 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    18 white prepupae new    30 white prepupae 12hr    3 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    18 adult male 01day    277 adult male 05day    169 adult male 30day    131 adult female 01day    137 adult female 05day    94 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    11 embryonic Kc167    16 embryonic S1    0 embryonic S3    2 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    88 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    79 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    392 Ethanol 10% 3 hrs, larvae L3    276 Caffeine 1.5 mg/ml 4 hrs, larvae L3    178 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    141 Rotenone 8 μg 12 hrs, larvae L3    185 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult  (119) Cadmium 50 mM 6 hrs, larvae L3  (88) Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (79) Ethanol 2.5% 3 hrs, larvae L3  (56) Ethanol 5% 3 hrs, larvae L3  (392) Ethanol 10% 3 hrs, larvae L3  (276) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (178) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (105) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (78) Paraquat 10 mM 48 hrs, 4-day adult  (51) Rotenone 2 μg 12 hrs, larvae L3  (141) Rotenone 8 μg 12 hrs, larvae L3  (185) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult  (119) Cadmium 50 mM 6 hrs, larvae L3    88 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    79 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3  (392) Ethanol 10% 3 hrs, larvae L3  (276) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (178) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  105 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3  (141) Rotenone 8 μg 12 hrs, larvae L3  (185) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    88 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    79 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    392 Ethanol 10% 3 hrs, larvae L3    276 Caffeine 1.5 mg/ml 4 hrs, larvae L3    178 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    141 Rotenone 8 μg 12 hrs, larvae L3    185 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    88 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    79 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    392 Ethanol 10% 3 hrs, larvae L3    276 Caffeine 1.5 mg/ml 4 hrs, larvae L3    178 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    141 Rotenone 8 μg 12 hrs, larvae L3    185 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult  (119) Cadmium 50 mM 6 hrs, larvae L3  (88) Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (79) Ethanol 2.5% 3 hrs, larvae L3  (56) Ethanol 5% 3 hrs, larvae L3  (392) Ethanol 10% 3 hrs, larvae L3  (276) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (178) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (105) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (78) Paraquat 10 mM 48 hrs, 4-day adult  (51) Rotenone 2 μg 12 hrs, larvae L3  (141) Rotenone 8 μg 12 hrs, larvae L3  (185) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult  119 Cadmium 50 mM 6 hrs, larvae L3    88 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (188) Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    79 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3  (392) Ethanol 10% 3 hrs, larvae L3  (276) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (178) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  105 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3  141 Rotenone 8 μg 12 hrs, larvae L3  (185) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    11 heat shock, 4-day adult    119 Cadmium 50 mM 6 hrs, larvae L3    88 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    188 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    79 Ethanol 2.5% 3 hrs, larvae L3    56 Ethanol 5% 3 hrs, larvae L3    392 Ethanol 10% 3 hrs, larvae L3    276 Caffeine 1.5 mg/ml 4 hrs, larvae L3    178 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    105 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    141 Rotenone 8 μg 12 hrs, larvae L3    185 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • GH03691 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000406 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13279-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cyt-b5-r Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Cyt-b5-rGD408 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Cyt-b5-r Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyt-b5-r Class Mutagen Stocks Known lesion Cyt-b5-rGD408 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cyt-b5-rKK104600 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyt-b5-rNIG.13279R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6039 (Ryder, 2004.4.26) Df(2L)Exel7067 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD408} NA P{KK104600} NA P{NIG.13279R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH1156SH1156 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) mitochondrion inferred from direct assay (Kula and Rozek, 2000)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
electron carrier activity non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) heme binding inferred from electronic annotation with InterPro:IPR001199, InterPro:IPR012171, InterPro:IPR018506 (FlyBase Curators et al., 2004-) iron ion binding inferred from electronic annotation with InterPro:IPR012171 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water inferred from electronic annotation with InterPro:IPR012171 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
fatty acid biosynthetic process inferred from electronic annotation with InterPro:IPR012171 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR012171 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cyt-b5-r - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - CG13010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - CG14715 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - CG15522 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Cyt-b5-r - CG18081 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - CG4325 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - capt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cyt-b5-r - sun experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyt-b5-r allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61015 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000406 DroID - A comprehensive database of gene and protein interactions. • FBgn0000406 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35008
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65DX87 Dipteran inclusive ortholog search EOG6K6GCN Insect inclusive ortholog search EOG64J1DT Arthropod inclusive ortholog search EOG61C5C0 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG65DX87)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cyt-b5-r     Drosophila simulans   Dsim\GD21896 Y   Drosophila sechellia   Dsec\GM17157 Y   Drosophila erecta   Dere\GG20107 Y   Drosophila yakuba   Dyak\GE13163 Y   Drosophila ananassae   Dana\GF14544 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12166 Y   Drosophila persimilis   Dper\GL19332 Y   Drosophila willistoni   Dwil\GK18156 Y   Drosophila virilis   Dvir\Cyt-b5-r Y   Drosophila mojavensis   Dmoj\GI14919 Y   Drosophila grimshawi   Dgri\GH10203 Y
Orthologs in non-Drosophila Dipterans (EOG6K6GCN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005737 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004278 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010150 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010149 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000854 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000855 Y
Orthologs in non-Dipteran Insects (EOG64J1DT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45951 Y Apis mellifera Western honey bee  Amel\Ame.17490 Y Apis mellifera Western honey bee  Amel\Y-b Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG033442 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003939 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003940 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13625 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12825 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13624 Y Atta cephalotes Leafcutter ant  Acep\ACEP16867 Y Atta cephalotes Leafcutter ant  Acep\ACEP22023 Y Atta cephalotes Leafcutter ant  Acep\ACEP14039 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22445 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22379 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22446 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20965 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13909 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15431 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13910 Y Linepithema humile Argentine ant  Lhum\LH18894 Y Linepithema humile Argentine ant  Lhum\LH18462 Y Linepithema humile Argentine ant  Lhum\LH26191 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16370 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11871 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11872 Y Solenopsis invicta Red fire ant  Sinv\SINV22954 Y Solenopsis invicta Red fire ant  Sinv\SINV22945 Y Solenopsis invicta Red fire ant  Sinv\SINV13064 Y Solenopsis invicta Red fire ant  Sinv\SINV22952 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007414 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003061 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006825 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005012 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI088353 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012486 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012487 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014224 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000418 Y Pediculus humanus Human body louse  Phum\PHUM322310 Y Pediculus humanus Human body louse  Phum\PHUM392460 Y Tribolium castaneum Red flour beetle  Tcas\TC006232 Y Tribolium castaneum Red flour beetle  Tcas\TC016299 Y Tribolium castaneum Red flour beetle  Tcas\TC005480 Y Tribolium castaneum Red flour beetle  Tcas\TC006231 Y
Orthologs in non-Insect Arthropods (EOG61C5C0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_3229 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21896 Drosophila sechellia Dsec\GM17157 Drosophila erecta Dere\GG20107 Drosophila yakuba Dyak\GE13163 Drosophila ananassae Dana\GF14544 Drosophila pseudoobscura pseudoobscura Dpse\GA12166 Drosophila persimilis Dper\GL19332 Drosophila willistoni Dwil\GK18156 Drosophila virilis Dvir\Cyt-b5-r Drosophila mojavensis Dmoj\GI14919 Drosophila grimshawi Dgri\GH10203
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v100507 P{KK104600}VIE-260B v42472 w1118 P{GD408}v42472 v42474 w1118; P{GD408}v42474/TM3
Genomic Clones ( 1 )
	BACR26O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 93 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03691
Other clones	DPiM_GH03691
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02356 GH02507 GH02787 GH02836 GH04189 GH04234 GH04592 GH04881 GH05162 GH05401 GH05861 GH07094 GH07974 GH08225 GH08787 GH09674 GH10513 GH10917 GH12119 GH12921 GH14651 GH15385 GH15414 GH15560 GH16132 GH16375 GH16742 GH16840 GH17772 GH18379 GH18667 GH18705 GH20128 GH20283 GH20404 GH20853 GH22140 GH23103 GH23289 GH23307 GH23311 GH23988 GH24419 GH24656 GH24866 GH26492 GH26842 GH27230 GH27307 GH27710 GH28791 HL01023 HL01051 HL02304 HL02937 HL04370 HL04932 HL05925 LP05271 RE07719 RE09346 RE19836 RE33490 RE34678 RE61950 RE74884 RE74986 RH26673 RH27987 RH29691 RH36543 RH38103
Other clones	35353 74236 193056 CK01.124C.H10 Dmel_dig_007475_0591_1911 Dmel_dig_012727_0711_0993 Dmel_dig_020097_0674_3011 Dmel_dig_020288_0593_3306 Dmel_neb_014573_0908_2879 EK094761 EK296024 IP03152 IP12067 IP14038 IP14342 RP001002217 RP001013516 RP001021551 RP001028080
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000406 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35008
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Transcription of Cyt-b5-r influences the polyadenylation pattern of the convergently transcribed and coexpressed Mhc gene. (Kula and Rozek, 1992) Cyt-b5-r is located 3' to Mhc and is expressed in the same muscle tissues as Mhc. Overall orientation not stated: Cyt-b5-r? Mhc- (Levin et al., 1989) Encodes a cytochrome-b homologue that is expressed specifically in muscles; expression is concordant with that of Mhc.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057806 NM_001273585 RefSeq (Proteins) • NP_477154 NP_001260514 DDBJ / EMBL / GenBank • AAF53567 AAF53567.1 AAL13516 AC005119 AC093097 AGB93049 AI063726 AW940138 AY058287 CAA33113 X15008 Entrez Gene - A searchable database of RefSeq genes. • 35008 UniProtKB/Swiss-Prot • P19967
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b5, heme-binding site (IPR018506) Cytochrome b5-like heme/steroid binding domain (IPR001199) Fatty acid desaturase, type 1 (IPR005804) Fatty acid/sphingolipid desaturase (IPR012171) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH03691
Linkouts
	BioGRID - A database of protein and genetic interactions • 61015 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000406 DroID - A comprehensive database of gene and protein interactions. • FBgn0000406 DRSC - Results from RNAi screens. • FBgn0000406 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000406 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13279-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000406 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35008 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35008 modMine - Data generated by the modENCODE project. • FBgn0000406
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG13279 (Keleman et al., 2009.8.5, Wittkopp et al., 2008, Cammarato et al., 2011) Cyt-b (Kula and Rozek, 2000, ) Cytb (Maroni, 1994) Cyt-b5 (Dunn et al., 2001, Kliman and Eyre-Walker, 1998, Moriyama and Powell, 1997, ) Cytb5   Cyt-b5-r (Beller et al., 2006, Lemos et al., 2008, Gallach et al., 2010, Wittkopp et al., 2008, Japanese National Institute of Genetics, 2012.5.21) Cytb5r (Zhao et al., 2012) TU-36B (Rozek, 1989.6.5, Kula and Rozek, 1992, Levin et al., 1989) TU36B
Name Synonym	Cytochrome b5-related (Sun et al., 2006, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 10 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 2 )
	Vesala et al., 2012, Insect Mol. Biol. 21(1): 107--118 Cold tolerance and cold-induced modulation of gene expression in two Drosophila virilis group species with different distributions. [FBrf0217233] Zhao et al., 2012, J. Clin. Invest. 122(7): 2417--2427 Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. [FBrf0218723] Show all research papers ...