disabled
adaptor protein that is a core component of the Abl tyrosine kinase signaling pathway - interacts with Abl to regulate axon guidance - associates with transmembrane receptors including N and Appl - involved in axon patterning, embryo morphogenesis and trafficking in endocytosis, exocytosis and Golgi organization discoidindomainrec.htm
Please see the JBrowse view of Dmel\Dab for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
8-8.5 (northern blot)
None of the polypeptides share 100% sequence identity.
2411, 2198 (aa); 250, 220 (kD)
Binds the SH3 domains of drk via the Pro-rich domain. When phosphorylated, can interact with the SH2 domains of drk. Binds sev via the phosphotyrosine interaction domain (PID).
Probably phosphorylated by the Abl tyrosine kinase. Phosphorylated on tyrosine residues in response to sevenless activation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dab using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
During gastrulation, Dab protein is broadly distributed. During germ band retraction, higher levels are seen in the mesoderm and in the central nervous system. Later in development, the message is concentrated in axon bundles. Dab protein is also detected in PNS cell clusters and in the body wall musculature.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dab in JBrowse3-44
3-39.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
A PID, phosphotyrosine interaction domain, has been found in the Dab protein. PID is a protein protein interaction motif that binds to the Asn-Pro-X-Tyr(P) motif found in many tyrosine phosphorylated proteins.
All five mutations originally thought to be lesions in the Dab gene (see FBrf0049327, FBrf0058531 and FBrf0084025) are actually lesions in the Nrt gene, the alleles are: NrtM2, NrtM29, NrtM54, NrtM100 and NrtM221.
FlyBase curator comment: in FBrf0058531, the NrtM2 allele is stated to be due to a lesion in the Dab gene, since four copies of a rescue construct containing Dab sequences (P{Dab.G}) rescue the lethality of NrtM2 Df(3L)st-j7/Abl1 animals. However this has subsequently been shown to be an error (see FBrf0162067) - the NrtM2 allele is actually due to a lesion in the Nrt gene.
The original gene name "Disabled" (Dab) was changed to "Dab adaptor protein" (Dab) to reflect its homology to the human gene and eliminate its potentially offensive association with human disability.
