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Gene Dmel\Sap-r

General Information
Symbol	Dmel\Sap-r	Species	D. melanogaster
Name	Saposin-related	Annotation symbol	CG12070
Feature type	protein_coding_gene	FlyBase ID	FBgn0000416
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	P110
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100A6-100A7	Sequence location	3R:26,709,186..26,714,784 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Saposin-related is referred to in FlyBase by the symbol Dmel\Sap-r (CG12070, FBgn0000416). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: dsRNA transport. 11 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Saposin; Saposin B; Saposin type A; Saposin-like; Saposin-like type B, 1; Saposin-like type B, 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640070_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Sap-r. Gene sequence location is 3R:26709186..26714784.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100A6-100A7   Limits computationally determined from genome sequence between P{lacW}l(3)s2500s2500 and P{PZ}Aph-407028&P{PZ}dcorK215
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100A-100B     (Galewsky, 1999.6.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sap-r for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated. Evidence indicates that 3' UTR overlaps 5' UTR of downstream gene CG15547
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sap-r-RA FBtr0085713  NM_079858   3440   953 Sap-r-RB FBtr0085714  NM_170529   3349   876
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sap-r-PA   FBpp0085075   106.0   953   4.59     NP_524597   AAF57097 Sap-r-PB   FBpp0085076   97.6   876   4.53     NP_733408   AAN14261
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Saposin type A (IPR003119) Saposin-like type B, 1 (IPR007856) Saposin-like type B, 2 (IPR008138) Saposin B (IPR008139) Saposin (IPR008373) Saposin-like (IPR011001)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202696   AA246440   AA264558   AA264629   AA264729   AA392367   AA392544   AA439502   AA441429   AA536314   AA536484   AA539553   AA540351   AA567991   AA695310   AA698333   AA698898   AA699145   AA735318   AA736229   AA801776   AA941160   AE014297 AAF57097   AE014297 AAN14261   AF145647 AAD38622   AF162129 AAD45802   AI062324   AI064400   AI107072   AI107687   AI108030   AI109190   AI113873   AI135354   AI135624   AI238697   AI257618   AI257723   AI259405   AI259408   AI259918   AI260523   AI294723   AI294914   AI295255   AI295845   AI296236   AI296936   AI297419   AI386703   AI387118   AI387354   AI388452   AI388845   AI389130   AI402127   AI403116   AI406209   AI467774   AI513367   AI513960   AI520459   AI531003   AI531035   AI531293   AI531835   AI532855   AI533207   AI533297   AI533954   AI533995   AI534001   AI534258   AI535011   AI542574   AI543729   AI544293   AI546560   AI546727   AI945445   BE976852   BF485896   BF488477   BF491486   BF491609   BF493015   BF493628   BF496529   BF497132   BF497429   BF498511   BF498849   BF501201   BF502001   BF502003   BF504414   BF504749   BF504810   BF504935   BF505793   BF506088   BG635802   BG635894   BG638205   BG640097   BG640658   BG641279   BI166277   BI171062   BI173425   BI173921   BI212495   BI215925   BI216485   BI216975   BI227927   BI229441   BI237488   BI238812   BI240072   BI242371   BI242441   BI353108   BI356489   BI356685   BI357089   BI357951   BI361961   BI364680   BI370741   BI371440   BI372681   BI374572   BI482798   BI486151   BI574092   BI574093   BI579374   BI592906   BI593045   BI606665   BI608711   BI610573   BI611305   BI611333   BI617668   BI620468   BI621496   BI625568   BI628397   BI629618   BI631993   BI635920   BI636500   BI636625   BI637055   BI638705   BI639160   BI639340   BI639430   BI641690   BP554438   BP554439   BP557555   BP557556   BT003256 AAO25013   CA803814   CA803926   CA804728   CA806792   CA806871   CA806935   CA807132   CA807257   CA807369   CA807487   CA807557   CA807587   CK131397   CK132082   CK132171   CK132850   CK657434   CK657679   CK657763   CK659541   CK659726   CK660118   CK660167   CK661110   CK661254   CK661594   CK661722   CK662346   CK662506   CO153187   CO153290   CO154766   CO176987   CO179963   CO180556   CO182910   CO189492   CO191147   CO267363   CO267393   CO276170   CO276501   CO278517   CO280788   CO281713   CO282982   CO287024   CO292288   CO296337   CO296867   CO299504   CO302731   CO302782   CO304586   CO304704   CO307153   CO322827   CO323140   CO323216   CO330270   CO330980   CO338741   CZ471567   CZ479100   CZ489518   DQ062780 AAY56653   EC057834   EC058211   EC061147   EC061671   EC062287   EC063193   EC063614   EC065432   EC067455   EC073124   EC077506   EC082904   EC083088   EC199370   EC199703   EC210021   EC213051   EC213168   EC231999   EC234240   EC237397   EC237529   EC237722   EC241557   EC246516   EC246593   EC250859   EC264534   EC265425   EC265617   EC268042   EL873637   EL873638   EL873731   EL873839   EL873840   EL874853   ES690144   ES691439   EV577970   EV583896   EV587921   EV589955   EV592300   EV598927   GH738786   GH739279   GH741333   GH744097   GH747294   GH761733   GH761867   GH762445   GH763029   GH764957   GH767502   GH768197   GH768238   GH769089   GH769713   GH779494   GH779701   GH779851   GO254534
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IMH4 Q9Y125 Q86PA4 Q9U9P3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    974.35 Larval Midgut    5262 Larval Hindgut    2969.8 Larval Malpighian Tubules    4489.6 Larval Fat Body    2553.5 Larval Salivary Gland    2453.4 Larval Trachea    1917.125 Larval Carcass    2566.075 Adult Head    2466.6 Adult Eye    3225.95 Adult Brain    1161.5 Adult Thoracic-Abdominal Ganglion    1238.7 Adult Crop    2204.2 Adult Midgut    3458.3 Adult Hindgut    2612.3 Adult Malpighian Tubules    4092.2 Adult Fat Body    4285.8 Adult Salivary Gland    6374.7 Adult Heart    4529.175 Adult VirginFemale Spermatheca    4829.2 Adult InseminatedFemale Spermatheca    4279.2 Adult Ovary    1415.4 Adult Testis    1057.9 Adult Male Accessory Gland    2908.5 Adult Carcass    3174.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (974.35) Larval Midgut  (5262) Larval Hindgut  (2969.8) Larval Malpighian Tubules  (4489.6) Larval Fat Body  (2553.5) Larval Salivary Gland  (2453.4) Larval Trachea  (1917.125) Larval Carcass  (2566.075) Adult Head  (2466.6) Adult Eye  (3225.95) Adult Brain  (1161.5) Adult Thoracic-Abdominal Ganglion  (1238.7) Adult Crop  (2204.2) Adult Midgut  (3458.3) Adult Hindgut  (2612.3) Adult Malpighian Tubules  (4092.2) Adult Fat Body  (4285.8) Adult Salivary Gland  (6374.7) Adult Heart  (4529.175) Adult VirginFemale Spermatheca  (4829.2) Adult InseminatedFemale Spermatheca  (4279.2) Adult Ovary  (1415.4) Adult Testis  (1057.9) Adult Male Accessory Gland  (2908.5) Adult Carcass  (3174.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    974.35 Larval Midgut  (5262) Larval Hindgut  (2969.8) Larval Malpighian Tubules  (4489.6) Larval Fat Body  (2553.5) Larval Salivary Gland  (2453.4) Larval Trachea  (1917.125) Larval Carcass  (2566.075) Adult Head  (2466.6) Adult Eye  (3225.95) Adult Brain  (1161.5) Adult Thoracic-Abdominal Ganglion  (1238.7) Adult Crop  (2204.2) Adult Midgut  (3458.3) Adult Hindgut  (2612.3) Adult Malpighian Tubules  (4092.2) Adult Fat Body  (4285.8) Adult Salivary Gland  (6374.7) Adult Heart  (4529.175) Adult VirginFemale Spermatheca  (4829.2) Adult InseminatedFemale Spermatheca  (4279.2) Adult Ovary  (1415.4) Adult Testis  1057.9 Adult Male Accessory Gland  (2908.5) Adult Carcass  (3174.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    974.35 Larval Midgut    5262 Larval Hindgut    2969.8 Larval Malpighian Tubules    4489.6 Larval Fat Body    2553.5 Larval Salivary Gland    2453.4 Larval Trachea    1917.125 Larval Carcass    2566.075 Adult Head    2466.6 Adult Eye    3225.95 Adult Brain    1161.5 Adult Thoracic-Abdominal Ganglion    1238.7 Adult Crop    2204.2 Adult Midgut    3458.3 Adult Hindgut    2612.3 Adult Malpighian Tubules    4092.2 Adult Fat Body    4285.8 Adult Salivary Gland    6374.7 Adult Heart    4529.175 Adult VirginFemale Spermatheca    4829.2 Adult InseminatedFemale Spermatheca    4279.2 Adult Ovary    1415.4 Adult Testis    1057.9 Adult Male Accessory Gland    2908.5 Adult Carcass    3174.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    974.35 Larval Midgut    5262 Larval Hindgut    2969.8 Larval Malpighian Tubules    4489.6 Larval Fat Body    2553.5 Larval Salivary Gland    2453.4 Larval Trachea    1917.125 Larval Carcass    2566.075 Adult Head    2466.6 Adult Eye    3225.95 Adult Brain    1161.5 Adult Thoracic-Abdominal Ganglion    1238.7 Adult Crop    2204.2 Adult Midgut    3458.3 Adult Hindgut    2612.3 Adult Malpighian Tubules    4092.2 Adult Fat Body    4285.8 Adult Salivary Gland    6374.7 Adult Heart    4529.175 Adult VirginFemale Spermatheca    4829.2 Adult InseminatedFemale Spermatheca    4279.2 Adult Ovary    1415.4 Adult Testis    1057.9 Adult Male Accessory Gland    2908.5 Adult Carcass    3174.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (974.35) Larval Midgut  (5262) Larval Hindgut  (2969.8) Larval Malpighian Tubules  (4489.6) Larval Fat Body  (2553.5) Larval Salivary Gland  (2453.4) Larval Trachea  (1917.125) Larval Carcass  (2566.075) Adult Head  (2466.6) Adult Eye  (3225.95) Adult Brain  (1161.5) Adult Thoracic-Abdominal Ganglion  (1238.7) Adult Crop  (2204.2) Adult Midgut  (3458.3) Adult Hindgut  (2612.3) Adult Malpighian Tubules  (4092.2) Adult Fat Body  (4285.8) Adult Salivary Gland  (6374.7) Adult Heart  (4529.175) Adult VirginFemale Spermatheca  (4829.2) Adult InseminatedFemale Spermatheca  (4279.2) Adult Ovary  (1415.4) Adult Testis  (1057.9) Adult Male Accessory Gland  (2908.5) Adult Carcass  (3174.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    974.35 Larval Midgut  (5262) Larval Hindgut  (2969.8) Larval Malpighian Tubules  (4489.6) Larval Fat Body  (2553.5) Larval Salivary Gland  (2453.4) Larval Trachea  (1917.125) Larval Carcass  (2566.075) Adult Head  (2466.6) Adult Eye  (3225.95) Adult Brain  1161.5 Adult Thoracic-Abdominal Ganglion  1238.7 Adult Crop  (2204.2) Adult Midgut  (3458.3) Adult Hindgut  (2612.3) Adult Malpighian Tubules  (4092.2) Adult Fat Body  (4285.8) Adult Salivary Gland  (6374.7) Adult Heart  (4529.175) Adult VirginFemale Spermatheca  (4829.2) Adult InseminatedFemale Spermatheca  (4279.2) Adult Ovary  1415.4 Adult Testis  1057.9 Adult Male Accessory Gland  (2908.5) Adult Carcass  (3174.1) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    974.35 Larval Midgut    5262 Larval Hindgut    2969.8 Larval Malpighian Tubules    4489.6 Larval Fat Body    2553.5 Larval Salivary Gland    2453.4 Larval Trachea    1917.125 Larval Carcass    2566.075 Adult Head    2466.6 Adult Eye    3225.95 Adult Brain    1161.5 Adult Thoracic-Abdominal Ganglion    1238.7 Adult Crop    2204.2 Adult Midgut    3458.3 Adult Hindgut    2612.3 Adult Malpighian Tubules    4092.2 Adult Fat Body    4285.8 Adult Salivary Gland    6374.7 Adult Heart    4529.175 Adult VirginFemale Spermatheca    4829.2 Adult InseminatedFemale Spermatheca    4279.2 Adult Ovary    1415.4 Adult Testis    1057.9 Adult Male Accessory Gland    2908.5 Adult Carcass    3174.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2466.6   NA  Eye    3225.95   NA  Brain    1161.5   974.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1238.7   NA  Crop    2204.2   5262  Midgut    3458.3   2969.8  Hindgut    2612.3   4489.6  Malpighian Tubules    4092.2   2553.5  Fat Body    4285.8   2453.4  Salivary Gland    6374.7   NA  Heart    4529.175   1917.125  Trachea    NA   NA  VirginFemale Spermatheca    4829.2   NA  InseminatedFemale Spermatheca    4279.2   NA  Ovary    1415.4   NA  Testis    1057.9   NA  Male Accessory Gland    2908.5   2566.075  Carcass    3174.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    225 central nervous system, larvae L3    179 central nervous system, pupae P8    122 head, virgin 1-day female    215 head, virgin 4-day female    277 head, virgin 20-day female    493 head, mated 1-day female    209 head, mated 4-day female    369 head, mated 20-day female    358 head, mated 1-day male    271 head, mated 4-day male    387 head, mated 20-day male    587 salivary gland, larvae L3 wandering    133 salivary gland, white prepupae    2097 digestive system, larvae L3 wandering    2066 digestive system, 1-day adult    409 digestive system, 4-day adult    356 digestive system, 20-day adult    479 fat body, larvae L3 wandering    162 fat body, white prepupae    280 fat body, pupae P8    261 carcass, larvae L3 wandering    481 carcass, 1-day adult    269 carcass, 4-day adult    314 carcass, 20-day adult    380 ovary, virgin 4-day female    254 ovary, mated 4-day female    236 testis, mated 4-day male    139 accessory gland, mated 4-day male    195 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (225) central nervous system, larvae L3  (179) central nervous system, pupae P8  (122) head, virgin 1-day female  (215) head, virgin 4-day female  (277) head, virgin 20-day female  (493) head, mated 1-day female  (209) head, mated 4-day female  (369) head, mated 20-day female  (358) head, mated 1-day male  (271) head, mated 4-day male  (387) head, mated 20-day male  (587) salivary gland, larvae L3 wandering  (133) salivary gland, white prepupae  (2097) digestive system, larvae L3 wandering  (2066) digestive system, 1-day adult  (409) digestive system, 4-day adult  (356) digestive system, 20-day adult  (479) fat body, larvae L3 wandering  (162) fat body, white prepupae  (280) fat body, pupae P8  (261) carcass, larvae L3 wandering  (481) carcass, 1-day adult  (269) carcass, 4-day adult  (314) carcass, 20-day adult  (380) ovary, virgin 4-day female  (254) ovary, mated 4-day female  (236) testis, mated 4-day male  (139) accessory gland, mated 4-day male  (195) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (225) central nervous system, larvae L3  (179) central nervous system, pupae P8  (122) head, virgin 1-day female  (215) head, virgin 4-day female  (277) head, virgin 20-day female  (493) head, mated 1-day female  (209) head, mated 4-day female  (369) head, mated 20-day female  (358) head, mated 1-day male  (271) head, mated 4-day male  (387) head, mated 20-day male  (587) salivary gland, larvae L3 wandering  (133) salivary gland, white prepupae  (2097) digestive system, larvae L3 wandering  (2066) digestive system, 1-day adult  (409) digestive system, 4-day adult  (356) digestive system, 20-day adult  (479) fat body, larvae L3 wandering  (162) fat body, white prepupae  (280) fat body, pupae P8  (261) carcass, larvae L3 wandering  (481) carcass, 1-day adult  (269) carcass, 4-day adult  (314) carcass, 20-day adult  (380) ovary, virgin 4-day female  (254) ovary, mated 4-day female  (236) testis, mated 4-day male  (139) accessory gland, mated 4-day male  (195) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    225 central nervous system, larvae L3    179 central nervous system, pupae P8    122 head, virgin 1-day female    215 head, virgin 4-day female    277 head, virgin 20-day female    493 head, mated 1-day female    209 head, mated 4-day female    369 head, mated 20-day female    358 head, mated 1-day male    271 head, mated 4-day male    387 head, mated 20-day male    587 salivary gland, larvae L3 wandering    133 salivary gland, white prepupae    2097 digestive system, larvae L3 wandering    2066 digestive system, 1-day adult    409 digestive system, 4-day adult    356 digestive system, 20-day adult    479 fat body, larvae L3 wandering    162 fat body, white prepupae    280 fat body, pupae P8    261 carcass, larvae L3 wandering    481 carcass, 1-day adult    269 carcass, 4-day adult    314 carcass, 20-day adult    380 ovary, virgin 4-day female    254 ovary, mated 4-day female    236 testis, mated 4-day male    139 accessory gland, mated 4-day male    195 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    225 central nervous system, larvae L3    179 central nervous system, pupae P8    122 head, virgin 1-day female    215 head, virgin 4-day female    277 head, virgin 20-day female    493 head, mated 1-day female    209 head, mated 4-day female    369 head, mated 20-day female    358 head, mated 1-day male    271 head, mated 4-day male    387 head, mated 20-day male    587 salivary gland, larvae L3 wandering    133 salivary gland, white prepupae    2097 digestive system, larvae L3 wandering    2066 digestive system, 1-day adult    409 digestive system, 4-day adult    356 digestive system, 20-day adult    479 fat body, larvae L3 wandering    162 fat body, white prepupae    280 fat body, pupae P8    261 carcass, larvae L3 wandering    481 carcass, 1-day adult    269 carcass, 4-day adult    314 carcass, 20-day adult    380 ovary, virgin 4-day female    254 ovary, mated 4-day female    236 testis, mated 4-day male    139 accessory gland, mated 4-day male    195 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (225) central nervous system, larvae L3  (179) central nervous system, pupae P8  (122) head, virgin 1-day female  (215) head, virgin 4-day female  (277) head, virgin 20-day female  (493) head, mated 1-day female  (209) head, mated 4-day female  (369) head, mated 20-day female  (358) head, mated 1-day male  (271) head, mated 4-day male  (387) head, mated 20-day male  (587) salivary gland, larvae L3 wandering  (133) salivary gland, white prepupae  (2097) digestive system, larvae L3 wandering  (2066) digestive system, 1-day adult  (409) digestive system, 4-day adult  (356) digestive system, 20-day adult  (479) fat body, larvae L3 wandering  (162) fat body, white prepupae  (280) fat body, pupae P8  (261) carcass, larvae L3 wandering  (481) carcass, 1-day adult  (269) carcass, 4-day adult  (314) carcass, 20-day adult  (380) ovary, virgin 4-day female  (254) ovary, mated 4-day female  (236) testis, mated 4-day male  (139) accessory gland, mated 4-day male  (195) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (225) central nervous system, larvae L3  (179) central nervous system, pupae P8  122 head, virgin 1-day female  (215) head, virgin 4-day female  (277) head, virgin 20-day female  (493) head, mated 1-day female  (209) head, mated 4-day female  (369) head, mated 20-day female  (358) head, mated 1-day male  (271) head, mated 4-day male  (387) head, mated 20-day male  (587) salivary gland, larvae L3 wandering  133 salivary gland, white prepupae  (2097) digestive system, larvae L3 wandering  (2066) digestive system, 1-day adult  (409) digestive system, 4-day adult  (356) digestive system, 20-day adult  (479) fat body, larvae L3 wandering  (162) fat body, white prepupae  (280) fat body, pupae P8  (261) carcass, larvae L3 wandering  (481) carcass, 1-day adult  (269) carcass, 4-day adult  (314) carcass, 20-day adult  (380) ovary, virgin 4-day female  (254) ovary, mated 4-day female  (236) testis, mated 4-day male  139 accessory gland, mated 4-day male  (195) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    225 central nervous system, larvae L3    179 central nervous system, pupae P8    122 head, virgin 1-day female    215 head, virgin 4-day female    277 head, virgin 20-day female    493 head, mated 1-day female    209 head, mated 4-day female    369 head, mated 20-day female    358 head, mated 1-day male    271 head, mated 4-day male    387 head, mated 20-day male    587 salivary gland, larvae L3 wandering    133 salivary gland, white prepupae    2097 digestive system, larvae L3 wandering    2066 digestive system, 1-day adult    409 digestive system, 4-day adult    356 digestive system, 20-day adult    479 fat body, larvae L3 wandering    162 fat body, white prepupae    280 fat body, pupae P8    261 carcass, larvae L3 wandering    481 carcass, 1-day adult    269 carcass, 4-day adult    314 carcass, 20-day adult    380 ovary, virgin 4-day female    254 ovary, mated 4-day female    236 testis, mated 4-day male    139 accessory gland, mated 4-day male    195 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    226 embryo 02-04hr    306 embryo 04-06hr    353 embryo 06-08hr    251 embryo 08-10hr    256 embryo 10-12hr    172 embryo 12-14hr    217 embryo 14-16hr    182 embryo 16-18hr    148 embryo 18-20hr    111 embryo 20-22hr    78 embryo 22-24hr    100 larva L1    70 larva L2    93 larva L3 12hr old    129 larva L3 puffstage 1-2    352 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    1065 white prepupae new    1315 white prepupae 12hr    560 white prepupae 24hr    389 pupae 2d postWPP    267 pupae 3d postWPP    266 pupae 4d postWPP    168 adult male 01day    361 adult male 05day    306 adult male 30day    261 adult female 01day    349 adult female 05day    328 adult female 30day    295 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (226) embryo 02-04hr  (306) embryo 04-06hr  (353) embryo 06-08hr  (251) embryo 08-10hr  (256) embryo 10-12hr  (172) embryo 12-14hr  (217) embryo 14-16hr  (182) embryo 16-18hr  (148) embryo 18-20hr  (111) embryo 20-22hr  (78) embryo 22-24hr  (100) larva L1  (70) larva L2  (93) larva L3 12hr old  (129) larva L3 puffstage 1-2  (352) larva L3 puffstage 3-6  (709) larva L3 puffstage 7-9  (1065) white prepupae new  (1315) white prepupae 12hr  (560) white prepupae 24hr  (389) pupae 2d postWPP  (267) pupae 3d postWPP  (266) pupae 4d postWPP  (168) adult male 01day  (361) adult male 05day  (306) adult male 30day  (261) adult female 01day  (349) adult female 05day  (328) adult female 30day  (295) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (226) embryo 02-04hr  (306) embryo 04-06hr  (353) embryo 06-08hr  (251) embryo 08-10hr  (256) embryo 10-12hr  (172) embryo 12-14hr  (217) embryo 14-16hr  (182) embryo 16-18hr  (148) embryo 18-20hr  (111) embryo 20-22hr    78 embryo 22-24hr    100 larva L1    70 larva L2    93 larva L3 12hr old  (129) larva L3 puffstage 1-2  (352) larva L3 puffstage 3-6  (709) larva L3 puffstage 7-9  (1065) white prepupae new  (1315) white prepupae 12hr  (560) white prepupae 24hr  (389) pupae 2d postWPP  (267) pupae 3d postWPP  (266) pupae 4d postWPP  (168) adult male 01day  (361) adult male 05day  (306) adult male 30day  (261) adult female 01day  (349) adult female 05day  (328) adult female 30day  (295) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    226 embryo 02-04hr    306 embryo 04-06hr    353 embryo 06-08hr    251 embryo 08-10hr    256 embryo 10-12hr    172 embryo 12-14hr    217 embryo 14-16hr    182 embryo 16-18hr    148 embryo 18-20hr    111 embryo 20-22hr    78 embryo 22-24hr    100 larva L1    70 larva L2    93 larva L3 12hr old    129 larva L3 puffstage 1-2    352 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    1065 white prepupae new    1315 white prepupae 12hr    560 white prepupae 24hr    389 pupae 2d postWPP    267 pupae 3d postWPP    266 pupae 4d postWPP    168 adult male 01day    361 adult male 05day    306 adult male 30day    261 adult female 01day    349 adult female 05day    328 adult female 30day    295 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    226 embryo 02-04hr    306 embryo 04-06hr    353 embryo 06-08hr    251 embryo 08-10hr    256 embryo 10-12hr    172 embryo 12-14hr    217 embryo 14-16hr    182 embryo 16-18hr    148 embryo 18-20hr    111 embryo 20-22hr    78 embryo 22-24hr    100 larva L1    70 larva L2    93 larva L3 12hr old    129 larva L3 puffstage 1-2    352 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    1065 white prepupae new    1315 white prepupae 12hr    560 white prepupae 24hr    389 pupae 2d postWPP    267 pupae 3d postWPP    266 pupae 4d postWPP    168 adult male 01day    361 adult male 05day    306 adult male 30day    261 adult female 01day    349 adult female 05day    328 adult female 30day    295 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (226) embryo 02-04hr  (306) embryo 04-06hr  (353) embryo 06-08hr  (251) embryo 08-10hr  (256) embryo 10-12hr  (172) embryo 12-14hr  (217) embryo 14-16hr  (182) embryo 16-18hr  (148) embryo 18-20hr  (111) embryo 20-22hr  (78) embryo 22-24hr  (100) larva L1  (70) larva L2  (93) larva L3 12hr old  (129) larva L3 puffstage 1-2  (352) larva L3 puffstage 3-6  (709) larva L3 puffstage 7-9  (1065) white prepupae new  (1315) white prepupae 12hr  (560) white prepupae 24hr  (389) pupae 2d postWPP  (267) pupae 3d postWPP  (266) pupae 4d postWPP  (168) adult male 01day  (361) adult male 05day  (306) adult male 30day  (261) adult female 01day  (349) adult female 05day  (328) adult female 30day  (295) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (226) embryo 02-04hr  (306) embryo 04-06hr  (353) embryo 06-08hr  (251) embryo 08-10hr  (256) embryo 10-12hr  (172) embryo 12-14hr  (217) embryo 14-16hr  (182) embryo 16-18hr  (148) embryo 18-20hr  111 embryo 20-22hr    78 embryo 22-24hr    100 larva L1    70 larva L2    93 larva L3 12hr old  129 larva L3 puffstage 1-2  (352) larva L3 puffstage 3-6  (709) larva L3 puffstage 7-9  (1065) white prepupae new  (1315) white prepupae 12hr  (560) white prepupae 24hr  (389) pupae 2d postWPP  (267) pupae 3d postWPP  (266) pupae 4d postWPP  (168) adult male 01day  (361) adult male 05day  (306) adult male 30day  (261) adult female 01day  (349) adult female 05day  (328) adult female 30day  (295) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    226 embryo 02-04hr    306 embryo 04-06hr    353 embryo 06-08hr    251 embryo 08-10hr    256 embryo 10-12hr    172 embryo 12-14hr    217 embryo 14-16hr    182 embryo 16-18hr    148 embryo 18-20hr    111 embryo 20-22hr    78 embryo 22-24hr    100 larva L1    70 larva L2    93 larva L3 12hr old    129 larva L3 puffstage 1-2    352 larva L3 puffstage 3-6    709 larva L3 puffstage 7-9    1065 white prepupae new    1315 white prepupae 12hr    560 white prepupae 24hr    389 pupae 2d postWPP    267 pupae 3d postWPP    266 pupae 4d postWPP    168 adult male 01day    361 adult male 05day    306 adult male 30day    261 adult female 01day    349 adult female 05day    328 adult female 30day    295 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    670 Schneider line 2 Sg4    264 embryonic 1182-4H    682 embryonic GM2    305 embryonic Kc167    297 embryonic S1    684 embryonic S3    299 leg disc CME L1    398 wing disc CME-W2    481 wing disc ML-DmD8    398 wing disc ML-DmD9    747 wing disc ML-DmD16-c3    421 wing disc ML-DmD21    143 wing disc ML-DmD32    328 haltere disc ML-DmD17-c3    387 eye-antennal disc ML-DmD11    425 antennal disc ML-DmD20-c5    503 mixed discs ML-DmD4-c1    592 CNS ML-DmBG1-c1    478 CNS ML-DmBG2-c2    691 tumorous blood cells mbn2    1044 ovary fGS/OSS    420 ovary OSC    239 ovary OSS    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (670) Schneider line 2 Sg4  (264) embryonic 1182-4H  (682) embryonic GM2  (305) embryonic Kc167  (297) embryonic S1  (684) embryonic S3  (299) leg disc CME L1  (398) wing disc CME-W2  (481) wing disc ML-DmD8  (398) wing disc ML-DmD9  (747) wing disc ML-DmD16-c3  (421) wing disc ML-DmD21  (143) wing disc ML-DmD32  (328) haltere disc ML-DmD17-c3  (387) eye-antennal disc ML-DmD11  (425) antennal disc ML-DmD20-c5  (503) mixed discs ML-DmD4-c1  (592) CNS ML-DmBG1-c1  (478) CNS ML-DmBG2-c2  (691) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (420) ovary OSC  (239) ovary OSS  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (670) Schneider line 2 Sg4  (264) embryonic 1182-4H  (682) embryonic GM2  (305) embryonic Kc167  (297) embryonic S1  (684) embryonic S3  (299) leg disc CME L1  (398) wing disc CME-W2  (481) wing disc ML-DmD8  (398) wing disc ML-DmD9  (747) wing disc ML-DmD16-c3  (421) wing disc ML-DmD21  (143) wing disc ML-DmD32  (328) haltere disc ML-DmD17-c3  (387) eye-antennal disc ML-DmD11  (425) antennal disc ML-DmD20-c5  (503) mixed discs ML-DmD4-c1  (592) CNS ML-DmBG1-c1  (478) CNS ML-DmBG2-c2  (691) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (420) ovary OSC  (239) ovary OSS  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    670 Schneider line 2 Sg4    264 embryonic 1182-4H    682 embryonic GM2    305 embryonic Kc167    297 embryonic S1    684 embryonic S3    299 leg disc CME L1    398 wing disc CME-W2    481 wing disc ML-DmD8    398 wing disc ML-DmD9    747 wing disc ML-DmD16-c3    421 wing disc ML-DmD21    143 wing disc ML-DmD32    328 haltere disc ML-DmD17-c3    387 eye-antennal disc ML-DmD11    425 antennal disc ML-DmD20-c5    503 mixed discs ML-DmD4-c1    592 CNS ML-DmBG1-c1    478 CNS ML-DmBG2-c2    691 tumorous blood cells mbn2    1044 ovary fGS/OSS    420 ovary OSC    239 ovary OSS    129 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    670 Schneider line 2 Sg4    264 embryonic 1182-4H    682 embryonic GM2    305 embryonic Kc167    297 embryonic S1    684 embryonic S3    299 leg disc CME L1    398 wing disc CME-W2    481 wing disc ML-DmD8    398 wing disc ML-DmD9    747 wing disc ML-DmD16-c3    421 wing disc ML-DmD21    143 wing disc ML-DmD32    328 haltere disc ML-DmD17-c3    387 eye-antennal disc ML-DmD11    425 antennal disc ML-DmD20-c5    503 mixed discs ML-DmD4-c1    592 CNS ML-DmBG1-c1    478 CNS ML-DmBG2-c2    691 tumorous blood cells mbn2    1044 ovary fGS/OSS    420 ovary OSC    239 ovary OSS    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (670) Schneider line 2 Sg4  (264) embryonic 1182-4H  (682) embryonic GM2  (305) embryonic Kc167  (297) embryonic S1  (684) embryonic S3  (299) leg disc CME L1  (398) wing disc CME-W2  (481) wing disc ML-DmD8  (398) wing disc ML-DmD9  (747) wing disc ML-DmD16-c3  (421) wing disc ML-DmD21  (143) wing disc ML-DmD32  (328) haltere disc ML-DmD17-c3  (387) eye-antennal disc ML-DmD11  (425) antennal disc ML-DmD20-c5  (503) mixed discs ML-DmD4-c1  (592) CNS ML-DmBG1-c1  (478) CNS ML-DmBG2-c2  (691) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (420) ovary OSC  (239) ovary OSS  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (670) Schneider line 2 Sg4  (264) embryonic 1182-4H  (682) embryonic GM2  (305) embryonic Kc167  (297) embryonic S1  (684) embryonic S3  (299) leg disc CME L1  (398) wing disc CME-W2  (481) wing disc ML-DmD8  (398) wing disc ML-DmD9  (747) wing disc ML-DmD16-c3  (421) wing disc ML-DmD21  143 wing disc ML-DmD32  (328) haltere disc ML-DmD17-c3  (387) eye-antennal disc ML-DmD11  (425) antennal disc ML-DmD20-c5  (503) mixed discs ML-DmD4-c1  (592) CNS ML-DmBG1-c1  (478) CNS ML-DmBG2-c2  (691) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (420) ovary OSC  (239) ovary OSS  129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    670 Schneider line 2 Sg4    264 embryonic 1182-4H    682 embryonic GM2    305 embryonic Kc167    297 embryonic S1    684 embryonic S3    299 leg disc CME L1    398 wing disc CME-W2    481 wing disc ML-DmD8    398 wing disc ML-DmD9    747 wing disc ML-DmD16-c3    421 wing disc ML-DmD21    143 wing disc ML-DmD32    328 haltere disc ML-DmD17-c3    387 eye-antennal disc ML-DmD11    425 antennal disc ML-DmD20-c5    503 mixed discs ML-DmD4-c1    592 CNS ML-DmBG1-c1    478 CNS ML-DmBG2-c2    691 tumorous blood cells mbn2    1044 ovary fGS/OSS    420 ovary OSC    239 ovary OSS    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    325 cold shock, 4-day adult    315 heat shock, 4-day adult    243 Cadmium 50 mM 6 hrs, larvae L3    210 Cadmium 50 mM 12 hrs, larvae L3    483 Cadmium 50 mM 48 hrs, 4-day adult    227 Cadmium 100 mM 48 hrs, 4-day adult    189 Copper 0.5 mM 12 hrs, larvae L3    143 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    171 Zinc 4.5 mM 48 hrs, 4-day adult    231 Ethanol 2.5% 3 hrs, larvae L3    282 Ethanol 5% 3 hrs, larvae L3    280 Ethanol 10% 3 hrs, larvae L3    222 Caffeine 1.5 mg/ml 4 hrs, larvae L3    511 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    256 Caffeine 25 mg/ml 48 hrs, 4-day adult    202 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    356 Rotenone 2 μg 12 hrs, larvae L3    287 Rotenone 8 μg 12 hrs, larvae L3    154 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (325) cold shock, 4-day adult  (315) heat shock, 4-day adult  (243) Cadmium 50 mM 6 hrs, larvae L3  (210) Cadmium 50 mM 12 hrs, larvae L3  (483) Cadmium 50 mM 48 hrs, 4-day adult  (227) Cadmium 100 mM 48 hrs, 4-day adult  (189) Copper 0.5 mM 12 hrs, larvae L3  (143) Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3  (171) Zinc 4.5 mM 48 hrs, 4-day adult  (231) Ethanol 2.5% 3 hrs, larvae L3  (282) Ethanol 5% 3 hrs, larvae L3  (280) Ethanol 10% 3 hrs, larvae L3  (222) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (511) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (256) Caffeine 25 mg/ml 48 hrs, 4-day adult  (202) Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (356) Rotenone 2 μg 12 hrs, larvae L3  (287) Rotenone 8 μg 12 hrs, larvae L3  (154) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (325) cold shock, 4-day adult  (315) heat shock, 4-day adult  (243) Cadmium 50 mM 6 hrs, larvae L3  (210) Cadmium 50 mM 12 hrs, larvae L3  (483) Cadmium 50 mM 48 hrs, 4-day adult  (227) Cadmium 100 mM 48 hrs, 4-day adult  (189) Copper 0.5 mM 12 hrs, larvae L3  (143) Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3  (171) Zinc 4.5 mM 48 hrs, 4-day adult  (231) Ethanol 2.5% 3 hrs, larvae L3  (282) Ethanol 5% 3 hrs, larvae L3  (280) Ethanol 10% 3 hrs, larvae L3  (222) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (511) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (256) Caffeine 25 mg/ml 48 hrs, 4-day adult  (202) Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (356) Rotenone 2 μg 12 hrs, larvae L3  (287) Rotenone 8 μg 12 hrs, larvae L3  (154) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    325 cold shock, 4-day adult    315 heat shock, 4-day adult    243 Cadmium 50 mM 6 hrs, larvae L3    210 Cadmium 50 mM 12 hrs, larvae L3    483 Cadmium 50 mM 48 hrs, 4-day adult    227 Cadmium 100 mM 48 hrs, 4-day adult    189 Copper 0.5 mM 12 hrs, larvae L3    143 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    171 Zinc 4.5 mM 48 hrs, 4-day adult    231 Ethanol 2.5% 3 hrs, larvae L3    282 Ethanol 5% 3 hrs, larvae L3    280 Ethanol 10% 3 hrs, larvae L3    222 Caffeine 1.5 mg/ml 4 hrs, larvae L3    511 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    256 Caffeine 25 mg/ml 48 hrs, 4-day adult    202 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    356 Rotenone 2 μg 12 hrs, larvae L3    287 Rotenone 8 μg 12 hrs, larvae L3    154 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    325 cold shock, 4-day adult    315 heat shock, 4-day adult    243 Cadmium 50 mM 6 hrs, larvae L3    210 Cadmium 50 mM 12 hrs, larvae L3    483 Cadmium 50 mM 48 hrs, 4-day adult    227 Cadmium 100 mM 48 hrs, 4-day adult    189 Copper 0.5 mM 12 hrs, larvae L3    143 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    171 Zinc 4.5 mM 48 hrs, 4-day adult    231 Ethanol 2.5% 3 hrs, larvae L3    282 Ethanol 5% 3 hrs, larvae L3    280 Ethanol 10% 3 hrs, larvae L3    222 Caffeine 1.5 mg/ml 4 hrs, larvae L3    511 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    256 Caffeine 25 mg/ml 48 hrs, 4-day adult    202 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    356 Rotenone 2 μg 12 hrs, larvae L3    287 Rotenone 8 μg 12 hrs, larvae L3    154 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (325) cold shock, 4-day adult  (315) heat shock, 4-day adult  (243) Cadmium 50 mM 6 hrs, larvae L3  (210) Cadmium 50 mM 12 hrs, larvae L3  (483) Cadmium 50 mM 48 hrs, 4-day adult  (227) Cadmium 100 mM 48 hrs, 4-day adult  (189) Copper 0.5 mM 12 hrs, larvae L3  (143) Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3  (171) Zinc 4.5 mM 48 hrs, 4-day adult  (231) Ethanol 2.5% 3 hrs, larvae L3  (282) Ethanol 5% 3 hrs, larvae L3  (280) Ethanol 10% 3 hrs, larvae L3  (222) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (511) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (256) Caffeine 25 mg/ml 48 hrs, 4-day adult  (202) Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (356) Rotenone 2 μg 12 hrs, larvae L3  (287) Rotenone 8 μg 12 hrs, larvae L3  (154) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (325) cold shock, 4-day adult  (315) heat shock, 4-day adult  (243) Cadmium 50 mM 6 hrs, larvae L3  (210) Cadmium 50 mM 12 hrs, larvae L3  (483) Cadmium 50 mM 48 hrs, 4-day adult  (227) Cadmium 100 mM 48 hrs, 4-day adult  (189) Copper 0.5 mM 12 hrs, larvae L3  143 Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3  (171) Zinc 4.5 mM 48 hrs, 4-day adult  (231) Ethanol 2.5% 3 hrs, larvae L3  (282) Ethanol 5% 3 hrs, larvae L3  (280) Ethanol 10% 3 hrs, larvae L3  (222) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (511) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (256) Caffeine 25 mg/ml 48 hrs, 4-day adult  (202) Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (356) Rotenone 2 μg 12 hrs, larvae L3  (287) Rotenone 8 μg 12 hrs, larvae L3  (154) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    325 cold shock, 4-day adult    315 heat shock, 4-day adult    243 Cadmium 50 mM 6 hrs, larvae L3    210 Cadmium 50 mM 12 hrs, larvae L3    483 Cadmium 50 mM 48 hrs, 4-day adult    227 Cadmium 100 mM 48 hrs, 4-day adult    189 Copper 0.5 mM 12 hrs, larvae L3    143 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    171 Zinc 4.5 mM 48 hrs, 4-day adult    231 Ethanol 2.5% 3 hrs, larvae L3    282 Ethanol 5% 3 hrs, larvae L3    280 Ethanol 10% 3 hrs, larvae L3    222 Caffeine 1.5 mg/ml 4 hrs, larvae L3    511 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    256 Caffeine 25 mg/ml 48 hrs, 4-day adult    202 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    356 Rotenone 2 μg 12 hrs, larvae L3    287 Rotenone 8 μg 12 hrs, larvae L3    154 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH08312 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000416 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12070-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Sap-r32 Sap-rCA07241 Sap-re01294 Sterility Allele fertile Sap-re01294 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Sap-r Class Mutagen Stocks Known lesion Sap-re01294 piggyBac transposase 2 -- Sap-r32 1 Yes Sap-rd00213 1 -- Sap-rd00389 P-element activity 1 -- Sap-rf05699 1 -- Sap-rMB07508 1 -- Sap-rNP7456 1 -- Sap-rCA07241 P-element activity 0 Yes Sap-rf06790 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sap-r Class Mutagen Stocks Known lesion Sap-rGD3133 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Sap-rNIG.12070R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3133} NA P{NIG.12070R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GA}Sap-rCA07241 NA P{UASp-YFP.Rab4}Sap-r32 NA PBac{RB}Sap-re01294 NA PBac{WH}Sap-rf05699 NA PBac{WH}Sap-rf06790 NA insertion of enhancer trap binary system Mi{ET1}Sap-rMB07508 No P{GawB}Sap-rNP7456 No insertion of mobile activating element P{XP}Sap-rd00213 NA P{XP}Sap-rd00389 NA P{XP}Sap-rd06073 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dsRNA transport inferred from mutant phenotype (Saleh et al., 2006)
Cellular Component
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
sphingolipid metabolic process inferred from electronic annotation with InterPro:IPR008373 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
lysosome inferred from electronic annotation with InterPro:IPR008373 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sap-r allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68512 DroID - A comprehensive database of gene and protein interactions. • FBgn0000416 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43662
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG698VK4 Dipteran inclusive ortholog search EOG6FFD8T Insect inclusive ortholog search EOG60P32Q Arthropod inclusive ortholog search EOG6B2RC3 Metazoa inclusive ortholog search EOG6M0SVH
Orthologs in Drosophila Species (EOG698VK4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sap-r     Drosophila simulans   Dsim\Sap-r Y   Drosophila sechellia   Dsec\GM12122 Y   Drosophila erecta   Dere\GG11904 Y   Drosophila yakuba   Dyak\GE23352 Y   Drosophila ananassae   Dana\GF23306 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11373 Y   Drosophila persimilis   Dper\GL13982 Y   Drosophila willistoni   Dwil\GK13103 Y   Drosophila virilis   Dvir\GJ22975 Y   Drosophila mojavensis   Dmoj\GI10623 Y   Drosophila grimshawi   Dgri\GH14090 Y
Orthologs in non-Drosophila Dipterans (EOG6FFD8T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003046   Anopheles gambiae Malaria mosquito  Agam\AGAP001082   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014133
Orthologs in non-Dipteran Insects (EOG60P32Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50421   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010253   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14373   Atta cephalotes Leafcutter ant  Acep\ACEP26235   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19883   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23536   Linepithema humile Argentine ant  Lhum\LH13675   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16930   Solenopsis invicta Red fire ant  Sinv\SINV14066   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001569   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009721   Bombyx mori Silkmoth  Bmor\BGIBMGA014221   Bombyx mori Silkmoth  Bmor\BGIBMGA010419   Pediculus humanus Human body louse  Phum\PHUM424520   Tribolium castaneum Red flour beetle  Tcas\TC000449
Orthologs in non-Insect Arthropods (EOG6B2RC3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_302384   Ixodes scapularis Deer tick  Isca\ISCW011597
Orthologs in non-Arthropod Metazoa (EOG6M0SVH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\spp-8   Caenorhabditis elegans Nematode  Cele\spp-10   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016273gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013454gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008303gn   Danio rerio Zebrafish  Drer\si:ch211-283h6.6   Danio rerio Zebrafish  Drer\psap   Danio rerio Zebrafish  Drer\si:ch73-340n8.2   Xenopus tropicalis Western clawed frog  Xtro\psap   Gallus gallus Domestic chicken  Ggal\PSAP   Mus musculus House mouse  Mmus\ENSMUSG00000043430   Mus musculus House mouse  Mmus\Psap   Rattus norvegicus Norway rat  Rnor\Psap   Homo sapiens Human  Hsap\PSAPL1   Homo sapiens Human  Hsap\PSAP
Human Orthologs (2)
Gene OMIM HGNC Hsap\PSAPL1     Hsap\PSAP
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Sap-r Drosophila sechellia Dsec\GM12122 Drosophila erecta Dere\GG11904 Drosophila yakuba Dyak\GE23352 Drosophila ananassae Dana\GF23306 Drosophila pseudoobscura pseudoobscura Dpse\GA11373 Drosophila persimilis Dper\GL13982 Drosophila willistoni Dwil\GK13103 Drosophila virilis Dvir\GJ22975 Drosophila mojavensis Dmoj\GI10623 Drosophila grimshawi Dgri\GH14090
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	17937 w1118; PBac{RB}Sap-re01294 9767 y1 w*; P{UASp-YFP.Rab4}Sap-r32 25555 w1118; Mi{ET1}Sap-rMB07508 CG15547MB07508
Harvard	- P{XP}Sap-rd00213 - P{XP}Sap-rd00389 - PBac{RB}Sap-re01294 - PBac{WH}Sap-rf05699
Kyoto	105467 y* w*; P{GawB}Sap-rNP7456 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v51129 w1118 P{GD3133}v51129 v51130 w1118 P{GD3133}v51130
Genomic Clones ( 1 )
	BACR03C06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 274 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08312 LD25144
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01383 AT01942 AT05768 AT06621 AT06840 AT07077 AT08174 AT08470 AT10291 AT11224 AT11594 AT13406 AT16462 AT17605 AT17607 AT19972 AT23763 AT28235 AT28393 GH01484 GH04808 GH05503 GH05955 GH06364 GH10364 GH13050 GH13445 GH14789 GH16870 GH17558 GH17860 GH19374 GH19877 GH20224 GH22486 GH26434 GH26547 GH26988 GM02577 GM12975 GM22241 HL02092 HL04291 HL05904 HL08195 LD03182 LD05311 LD08245 LD08333 LD11287 LD11451 LD17114 LD17738 LD21104 LD40633 LP01764 LP02812 LP02816 LP03442 LP04423 LP06032 LP06177 LP08161 LP08402 LP08837 LP09604 LP10084 LP11059 LP11715 LP13327 LP13485 LP17367 LP17686 LP18392 LP18484 LP20266 LP21195 LP21389 LP22474 LP22780 LP23730 LP24171 LP24316 RE06349 RE12733 RE16340 RE17067 RE17593 RE22702 RE23628 RE24479 RE25318 RE27220 RE33723 RE36719 RE39676 RE41872 RE42656 RE42877 RE43445 RE44595 RE46401 RE49847 RE58330 RE59716 RE62201 RE69532 RH10722 RH10924 RH13378 RH16079 RH17491 RH17530 RH48070 RH51624 RH52846 RH56775 RH58515 RH61688 RH66023 RH73279 SD01353 SD01838 SD01895 SD02268 SD03113 SD04489 SD04955 SD05058 SD06315 SD06347 SD06411 SD06419 SD07025 SD08963 SD10616 SD10691 SD10792 SD11045 SD11789 SD12591 SD13285 SD13407 SD17458 SD18192 SD18367 SD18951 SD21063 SD21636 SD21903 SD22004 SD25236
Other clones	797 17646 17794 37459 37792 41459 47283 51027 63089 64229 64354 71623 80525 82040 117447 119557 123037 148248 192067 193447 522144 522253 524099 572922 AT12933 bs13a01 bs56g07 CK01.54D.C3 CK01.64A.C12 CK01.145D.E2 CK01.145D.E4 Dmel_dig_006900_0708_2549 Dmel_dig_020264_0674_1465 Dmel_neb_011939_0921_2864 Dmel_neb_012129_0150_0652 Dmel_neb_015120_0321_2078 Dmel_neb_015369_0599_2865 EC00645 EC02045 EC24269 EC30209 EK044410 EK052044 EK064643 EK119850 EK121164 EK130245 EK149552 EK150021 EK154853 EK158625 EK161929 EK175642 EK184807 EK184905 EK189017 EK189815 EK189954 EK199726 EK213416 EK215327 EK245221 EK245820 EK253745 EK294844 EK296760 EN01440 EN01650 EN04749 EN17522 ESG015a.E21_B12 ESG015b.E21_F11 ESG015c.E21.1_F09 ESG016b.E21_G01 ESG017a.E21_E09 ESG017c.E21.1_F01 ESG018a.E21_H04 ESG018c.E21_A11 ESG018c.E21.1_E08 ESG0110d.E21_A05 ESG0111b.B21_C04 ESG0115a.B21_A09 FGM229H05 FGM309H12 HL07792 IP13726 IP13826 IP13926 IP14929 LD08684 LD14088 LD16359 LD16858 LD19813 LP20587 RC0-DA0006-130700-012-A04 RE39766 RE57472 RE65559 RE73395 RH09487 RP01021 RP01592 RP001012283 RP001012329 RP001014118 RP001014815 RP001017824 RP001018264 RP001020415 RP001021694 RP001022330 RP001023868 RP001025398 RP001035420 RP001040504 RP001046661 RP001048637 RP001050536 RP001052468
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000416 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43662
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Sap-r anon-EST:ParkEST270 (Bayraktaroglu, 2000.11.2) Source for merge of: Sap-r BcDNA:GH08312 (FlyBase, 1996-)
Additional comments	Source for merge of Sap-r BcDNA:GH08312 was sequence comparison (date:000202). (FlyBase, 1996-)
Other Comments
	Contra FBrf0066300 this gene does not encode a product mediating cell adhesion. (Noll, 1996.8.17) Homozygotes for deficiencies removing Sap-r are fertile and viable and show no obvious phenotype. (Noll, 1996.8.17)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079858 NM_170529 RefSeq (Proteins) • NP_524597 NP_733408 DDBJ / EMBL / GenBank • AA941160 AAD38622 AAD45802 AAF57097 AAN14261 AAO25013 AAY56653 AF145647 AF162129 AI108030 AI109190 AI402127 AI467774 AI945445 BT003256 CZ471567 CZ479100 CZ489518 DQ062780 Entrez Gene - A searchable database of RefSeq genes. • 43662 UniProtKB/TrEMBL • Q8IMH4 Q9U9P3 Q9Y125 Q86PA4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Saposin type A (IPR003119) Saposin-like type B, 1 (IPR007856) Saposin-like type B, 2 (IPR008138) Saposin B (IPR008139) Saposin (IPR008373) Saposin-like (IPR011001) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH08312
Linkouts
	BioGRID - A database of protein and genetic interactions • 68512 DroID - A comprehensive database of gene and protein interactions. • FBgn0000416 DRSC - Results from RNAi screens. • FBgn0000416 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000416 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12070-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000416 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43662 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43662 modMine - Data generated by the modENCODE project. • FBgn0000416
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	anon-EST:ParkEST270   Apa   BcDNA:GH08312   CG12070 (Jagadeeshan and Singh, 2005, Saleh et al., 2006, Cammarato et al., 2011) DAPA (Frigerio et al., 1990, ) Ov9 (Jagadeeshan and Singh, 2005) P110 (Galewsky et al., 2000, Galewsky, 1999.6.23, ) sap-r (Freeman et al., 2003, Kuronen et al., 2009) Sapr (Hochstrasser et al., 1993) Sap-r (Buszczak et al., 2007, Hazelett et al., 2012, Zhang et al., 2007, Jagadeeshan and Singh, 2005, Lighthouse et al., 2008, Rehwinkel et al., 2004, Kuronen et al., 2009, Japanese National Institute of Genetics, 2012.5.21) Sap-R (Leatherbarrow and Halfon, 2009)
Name Synonym	110kD protein   Aggregation promoting activity   Drosophila Aggregation promoting activity   Saposin-r (Saleh et al., 2006) Saposin-related (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0026286 FBgn0027566
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...