Cyp302a1, cytochrome P450
Gene model reviewed during 5.44
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dib using the Feature Mapper tool.
dib transcripts are first observed at the early syncytial blastoderm stage where they are enriched in the anterior half of the embryo. As cellularization proceeds, posterior stripes appear and by germ band extension, dib is expressed in most epidermal cells. Expression then fades and by stage 12 is only observed in a small number of unidentified cells per segment. During dorsal closure, precursors of the ring gland express dib in the prothoracic region. Expression remains strong in the prothoracic portion of the ring gland through to stage 17. In wandering third instar larvae, expression is again observed in the prothoracic portion of the ring gland and the expression fades in prepupae. In adult females, expression is observed in follicle cells at stage 8 of oogenesis and is greatly diminished by stage 11.
GBrowse - Visual display of RNA-Seq signalsView Dmel\dib in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dib encodes a 22-hydroxylase that catalyses the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone in S2 cells.
Mutant embryos produce little or no cuticle and show severe defects in many late morphogenetic processes such as head involution, dorsal closure and gut development.
Four EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.