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Gene Dmel\Dip-B

General Information
Symbol	Dmel\Dip-B	Species	D. melanogaster
Name	Dipeptidase B	Annotation symbol	CG9285
Feature type	protein_coding_gene	FlyBase ID	FBgn0000454
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	DipB
Genomic Location
Chromosome (arm)	3R	Recombination map	3-53.6
Cytogenetic map	87F13-87F13	Sequence location	3R:9,608,012..9,611,401 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dipeptidase B is referred to in FlyBase by the symbol Dmel\Dip-B (CG9285, FBgn0000454). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tripeptidyl-peptidase activity; dipeptidyl-peptidase activity. There is experimental evidence that it is involved in the biological process: proteolysis. 7 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Leucine aminopeptidase/peptidase B; Peptidase M17, leucyl aminopeptidase, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, adult fat body, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635449_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Dip-B. Gene sequence location is 3R:9608012..9611401.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Dip-B: Dipeptidase B Structural gene for dipeptidase B [DIP-B(EC 3.4.14.?.)], which is virtually monomorphic in natural populations but which differs in electrophoretic mobility from dipeptidase-B variants in D. simulans. Substrate specificities determined by Laurie-Ahlberg (1982, Biochem. Genet. 20: 407-24).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87F13-87F13   Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-53.6 (Laurie-Ahlberg, 1982)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dip-B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dip-B-RA FBtr0082831  NM_142061   2035   508 Dip-B-RB FBtr0082833  NM_169557   1941   508 Dip-B-RC FBtr0082832  NM_169558   2048   508
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dip-B-PA   FBpp0082299   55.5   508   6.74     NP_650318   AAF54991 Dip-B-PB   FBpp0082301   55.5   508   6.74     NP_731863   AAN13593 Dip-B-PC   FBpp0082300   55.5   508   6.74     NP_731864   AAN13594
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M17, leucyl aminopeptidase, C-terminal (IPR000819) Leucine aminopeptidase/peptidase B (IPR011356)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246925   AA390686   AA735566   AA803435   AA817514   AA820781   AA941796   AA978443   AE014297 AAF54991   AE014297 AAN13593   AE014297 AAN13594   AI063047   AI107535   AI108373   AI257311   AI257909   AI258439   AI258501   AI259131   AI259963   AI293137   AI295982   AI296254   AI296720   AI386782   AI386883   AI387150   AI387654   AI390038   AI456913   AI456916   AI514526   AI514656   AI534783   AY051926 AAK93350   BF494243   BF498677   BF503868   BG637843   BI163050   BI166611   BI166888   BI229100   BI354948   BI372654   BI565003   BI566018   BI570232   BI579788   BI580444   BI590594   BI607513   BI610299   BI616726   BI621879   BI624210   BI636283   BQ103408   CK657282   CK659340   CK661716   CL705860   CO155110   CO182053   CO183969   CO193612   CO264830   CO280422   CO286591   CO294975   CO313992   CO320183   CO330854   CO331151   CZ475158   EC051185   EC052733   EC053219   EC053696   EC055861   EC072454   EC073294   EC078625   EC200554   EC237299   EC250823   EV578274   EV579319   EV579377   EV579686   EV581168   EV583556   EV584065   EV584289   EV586345   EV587765   EV590141   EV591161   EV591307   EV593223   EV598931   EV600758   GH941368   GH941379   GH941710   GH941857   GH941897   GH942112   GH943159   GH943580   GH943675   GH943788   GH943822   GH944116   GH944177   GH944984   GH945730   GH946048   GH946213   GH946351   GH946708   GH947473   GH947997   GH948344   GH948387   GH948698   GH948792   GH948850   GH949020   GH950046   GH950801   GH951195   GH952458   GH952841   GH953414   GH953641   GH953896   GH953916   GH954980   GH956850   GH957042   GH957728   GH957732   GH957867   GH959089   GH960670   GH961124   GH961335   GH961454   GH962644   GH962664   GH964296   GH965170   GH966655   GH967094   GH967856   GH967857   GH968802   GH969521   GH969950   GH970418   GH971042   GH971122   GH973126   GH974017   GH974637   GH975040   GH975346   GH975371   GH976897   GH977974   GH979297   GH979706   GH979923   GH980560   GH982230   GH982699   GH982957   GH982997   GH983521   GH983797   GH984938
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFQ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Dip-B is present atfairly uniform specific activities throughout development. Specificactivity is highest in pupae and lowest in feeding stages. Dip-Bspecific activity was also found to be fairly uniform in all tissuesstudied except in gut and Malphigian tubules where it is higher thanaverage and adult thorax where it is low.
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, adult fat body, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut    1761.7 Larval Hindgut    1024.7 Larval Malpighian Tubules    2800.3 Larval Fat Body    1411 Larval Salivary Gland    641.6 Larval Trachea    664.975 Larval Carcass    648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain    714.4 Adult Thoracic-Abdominal Ganglion    828.2 Adult Crop    251.4 Adult Midgut    1212.9 Adult Hindgut    557.8 Adult Malpighian Tubules    3175.4 Adult Fat Body    468.1 Adult Salivary Gland    623.6 Adult Heart    1214.725 Adult VirginFemale Spermatheca    717.2 Adult InseminatedFemale Spermatheca    591.6 Adult Ovary    1103.1 Adult Testis    610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut  (1761.7) Larval Hindgut  (1024.7) Larval Malpighian Tubules  (2800.3) Larval Fat Body  (1411) Larval Salivary Gland  (641.6) Larval Trachea  (664.975) Larval Carcass  (648.875) Adult Head    488.9 Adult Eye    239.675 Adult Brain  (714.4) Adult Thoracic-Abdominal Ganglion  (828.2) Adult Crop    251.4 Adult Midgut  (1212.9) Adult Hindgut  (557.8) Adult Malpighian Tubules  (3175.4) Adult Fat Body    468.1 Adult Salivary Gland  (623.6) Adult Heart  (1214.725) Adult VirginFemale Spermatheca  (717.2) Adult InseminatedFemale Spermatheca  (591.6) Adult Ovary  (1103.1) Adult Testis  (610.6) Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut  (1761.7) Larval Hindgut  1024.7 Larval Malpighian Tubules  (2800.3) Larval Fat Body  (1411) Larval Salivary Gland    641.6 Larval Trachea    664.975 Larval Carcass    648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain    714.4 Adult Thoracic-Abdominal Ganglion    828.2 Adult Crop    251.4 Adult Midgut  (1212.9) Adult Hindgut    557.8 Adult Malpighian Tubules  (3175.4) Adult Fat Body    468.1 Adult Salivary Gland    623.6 Adult Heart  (1214.725) Adult VirginFemale Spermatheca    717.2 Adult InseminatedFemale Spermatheca    591.6 Adult Ovary  (1103.1) Adult Testis    610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut    1761.7 Larval Hindgut    1024.7 Larval Malpighian Tubules    2800.3 Larval Fat Body    1411 Larval Salivary Gland    641.6 Larval Trachea    664.975 Larval Carcass    648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain    714.4 Adult Thoracic-Abdominal Ganglion    828.2 Adult Crop    251.4 Adult Midgut    1212.9 Adult Hindgut    557.8 Adult Malpighian Tubules    3175.4 Adult Fat Body    468.1 Adult Salivary Gland    623.6 Adult Heart    1214.725 Adult VirginFemale Spermatheca    717.2 Adult InseminatedFemale Spermatheca    591.6 Adult Ovary    1103.1 Adult Testis    610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut    1761.7 Larval Hindgut    1024.7 Larval Malpighian Tubules    2800.3 Larval Fat Body    1411 Larval Salivary Gland    641.6 Larval Trachea    664.975 Larval Carcass    648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain    714.4 Adult Thoracic-Abdominal Ganglion    828.2 Adult Crop    251.4 Adult Midgut    1212.9 Adult Hindgut    557.8 Adult Malpighian Tubules    3175.4 Adult Fat Body    468.1 Adult Salivary Gland    623.6 Adult Heart    1214.725 Adult VirginFemale Spermatheca    717.2 Adult InseminatedFemale Spermatheca    591.6 Adult Ovary    1103.1 Adult Testis    610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut  (1761.7) Larval Hindgut  (1024.7) Larval Malpighian Tubules  (2800.3) Larval Fat Body  (1411) Larval Salivary Gland  641.6 Larval Trachea  664.975 Larval Carcass  648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain  714.4 Adult Thoracic-Abdominal Ganglion  (828.2) Adult Crop    251.4 Adult Midgut  (1212.9) Adult Hindgut  557.8 Adult Malpighian Tubules  (3175.4) Adult Fat Body    468.1 Adult Salivary Gland  623.6 Adult Heart  (1214.725) Adult VirginFemale Spermatheca  717.2 Adult InseminatedFemale Spermatheca  591.6 Adult Ovary  (1103.1) Adult Testis  610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut  (1761.7) Larval Hindgut  1024.7 Larval Malpighian Tubules  (2800.3) Larval Fat Body  1411 Larval Salivary Gland    641.6 Larval Trachea    664.975 Larval Carcass    648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain    714.4 Adult Thoracic-Abdominal Ganglion    828.2 Adult Crop    251.4 Adult Midgut  1212.9 Adult Hindgut    557.8 Adult Malpighian Tubules  (3175.4) Adult Fat Body    468.1 Adult Salivary Gland    623.6 Adult Heart  1214.725 Adult VirginFemale Spermatheca    717.2 Adult InseminatedFemale Spermatheca    591.6 Adult Ovary  1103.1 Adult Testis    610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    436.225 Larval Midgut    1761.7 Larval Hindgut    1024.7 Larval Malpighian Tubules    2800.3 Larval Fat Body    1411 Larval Salivary Gland    641.6 Larval Trachea    664.975 Larval Carcass    648.875 Adult Head    488.9 Adult Eye    239.675 Adult Brain    714.4 Adult Thoracic-Abdominal Ganglion    828.2 Adult Crop    251.4 Adult Midgut    1212.9 Adult Hindgut    557.8 Adult Malpighian Tubules    3175.4 Adult Fat Body    468.1 Adult Salivary Gland    623.6 Adult Heart    1214.725 Adult VirginFemale Spermatheca    717.2 Adult InseminatedFemale Spermatheca    591.6 Adult Ovary    1103.1 Adult Testis    610.6 Adult Male Accessory Gland    331.1 Adult Carcass    381 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    488.9   NA  Eye    239.675   NA  Brain    714.4   436.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    828.2   NA  Crop    251.4   1761.7  Midgut    1212.9   1024.7  Hindgut    557.8   2800.3  Malpighian Tubules    3175.4   1411  Fat Body    468.1   641.6  Salivary Gland    623.6   NA  Heart    1214.725   664.975  Trachea    NA   NA  VirginFemale Spermatheca    717.2   NA  InseminatedFemale Spermatheca    591.6   NA  Ovary    1103.1   NA  Testis    610.6   NA  Male Accessory Gland    331.1   648.875  Carcass    381 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    84 digestive system, 4-day adult    57 digestive system, 20-day adult    61 fat body, larvae L3 wandering    26 fat body, white prepupae    106 fat body, pupae P8    218 carcass, larvae L3 wandering    37 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female    106 ovary, mated 4-day female    91 testis, mated 4-day male    54 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering  (56) digestive system, 1-day adult  (84) digestive system, 4-day adult  (57) digestive system, 20-day adult  (61) fat body, larvae L3 wandering  26 fat body, white prepupae  (106) fat body, pupae P8  (218) carcass, larvae L3 wandering  (37) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female  (106) ovary, mated 4-day female  (91) testis, mated 4-day male  (54) accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    84 digestive system, 4-day adult    57 digestive system, 20-day adult    61 fat body, larvae L3 wandering    26 fat body, white prepupae  106 fat body, pupae P8  (218) carcass, larvae L3 wandering    37 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female  106 ovary, mated 4-day female    91 testis, mated 4-day male    54 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    84 digestive system, 4-day adult    57 digestive system, 20-day adult    61 fat body, larvae L3 wandering    26 fat body, white prepupae    106 fat body, pupae P8    218 carcass, larvae L3 wandering    37 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female    106 ovary, mated 4-day female    91 testis, mated 4-day male    54 accessory gland, mated 4-day male    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    84 digestive system, 4-day adult    57 digestive system, 20-day adult    61 fat body, larvae L3 wandering    26 fat body, white prepupae    106 fat body, pupae P8    218 carcass, larvae L3 wandering    37 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female    106 ovary, mated 4-day female    91 testis, mated 4-day male    54 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering  (56) digestive system, 1-day adult  (84) digestive system, 4-day adult  (57) digestive system, 20-day adult  (61) fat body, larvae L3 wandering  26 fat body, white prepupae  (106) fat body, pupae P8  (218) carcass, larvae L3 wandering  (37) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female  (106) ovary, mated 4-day female  (91) testis, mated 4-day male  (54) accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    84 digestive system, 4-day adult    57 digestive system, 20-day adult    61 fat body, larvae L3 wandering    26 fat body, white prepupae  106 fat body, pupae P8  (218) carcass, larvae L3 wandering    37 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female  106 ovary, mated 4-day female    91 testis, mated 4-day male    54 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    22 central nervous system, pupae P8    17 head, virgin 1-day female    17 head, virgin 4-day female    18 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    13 head, mated 20-day female    17 head, mated 1-day male    19 head, mated 4-day male    20 head, mated 20-day male    21 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    84 digestive system, 4-day adult    57 digestive system, 20-day adult    61 fat body, larvae L3 wandering    26 fat body, white prepupae    106 fat body, pupae P8    218 carcass, larvae L3 wandering    37 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    18 ovary, virgin 4-day female    106 ovary, mated 4-day female    91 testis, mated 4-day male    54 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    166 embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr    48 embryo 16-18hr    75 embryo 18-20hr    72 embryo 20-22hr    64 embryo 22-24hr    56 larva L1    77 larva L2    147 larva L3 12hr old    120 larva L3 puffstage 1-2    101 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    135 white prepupae new    263 white prepupae 12hr    392 white prepupae 24hr    285 pupae 2d postWPP    233 pupae 3d postWPP    84 pupae 4d postWPP    90 adult male 01day    84 adult male 05day    84 adult male 30day    87 adult female 01day    196 adult female 05day    227 adult female 30day    240 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (166) embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr  (48) embryo 16-18hr  (75) embryo 18-20hr  (72) embryo 20-22hr  (64) embryo 22-24hr  (56) larva L1  (77) larva L2  (147) larva L3 12hr old  (120) larva L3 puffstage 1-2  (101) larva L3 puffstage 3-6  (102) larva L3 puffstage 7-9  (135) white prepupae new  (263) white prepupae 12hr  (392) white prepupae 24hr  (285) pupae 2d postWPP  (233) pupae 3d postWPP  (84) pupae 4d postWPP  (90) adult male 01day  (84) adult male 05day  (84) adult male 30day  (87) adult female 01day  (196) adult female 05day  (227) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (166) embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr    48 embryo 16-18hr    75 embryo 18-20hr    72 embryo 20-22hr    64 embryo 22-24hr    56 larva L1    77 larva L2  (147) larva L3 12hr old  (120) larva L3 puffstage 1-2  101 larva L3 puffstage 3-6  102 larva L3 puffstage 7-9  (135) white prepupae new  (263) white prepupae 12hr  (392) white prepupae 24hr  (285) pupae 2d postWPP  (233) pupae 3d postWPP    84 pupae 4d postWPP    90 adult male 01day    84 adult male 05day    84 adult male 30day    87 adult female 01day  (196) adult female 05day  (227) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    166 embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr    48 embryo 16-18hr    75 embryo 18-20hr    72 embryo 20-22hr    64 embryo 22-24hr    56 larva L1    77 larva L2    147 larva L3 12hr old    120 larva L3 puffstage 1-2    101 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    135 white prepupae new    263 white prepupae 12hr    392 white prepupae 24hr    285 pupae 2d postWPP    233 pupae 3d postWPP    84 pupae 4d postWPP    90 adult male 01day    84 adult male 05day    84 adult male 30day    87 adult female 01day    196 adult female 05day    227 adult female 30day    240 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    166 embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr    48 embryo 16-18hr    75 embryo 18-20hr    72 embryo 20-22hr    64 embryo 22-24hr    56 larva L1    77 larva L2    147 larva L3 12hr old    120 larva L3 puffstage 1-2    101 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    135 white prepupae new    263 white prepupae 12hr    392 white prepupae 24hr    285 pupae 2d postWPP    233 pupae 3d postWPP    84 pupae 4d postWPP    90 adult male 01day    84 adult male 05day    84 adult male 30day    87 adult female 01day    196 adult female 05day    227 adult female 30day    240 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (166) embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr  (48) embryo 16-18hr  (75) embryo 18-20hr  (72) embryo 20-22hr  (64) embryo 22-24hr  (56) larva L1  (77) larva L2  (147) larva L3 12hr old  (120) larva L3 puffstage 1-2  (101) larva L3 puffstage 3-6  (102) larva L3 puffstage 7-9  (135) white prepupae new  (263) white prepupae 12hr  (392) white prepupae 24hr  (285) pupae 2d postWPP  (233) pupae 3d postWPP  (84) pupae 4d postWPP  (90) adult male 01day  (84) adult male 05day  (84) adult male 30day  (87) adult female 01day  (196) adult female 05day  (227) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (166) embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr    48 embryo 16-18hr    75 embryo 18-20hr    72 embryo 20-22hr    64 embryo 22-24hr    56 larva L1    77 larva L2  (147) larva L3 12hr old  120 larva L3 puffstage 1-2  101 larva L3 puffstage 3-6  102 larva L3 puffstage 7-9  135 white prepupae new  (263) white prepupae 12hr  (392) white prepupae 24hr  (285) pupae 2d postWPP  (233) pupae 3d postWPP    84 pupae 4d postWPP    90 adult male 01day    84 adult male 05day    84 adult male 30day    87 adult female 01day  (196) adult female 05day  (227) adult female 30day  (240) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    166 embryo 02-04hr    16 embryo 04-06hr    6 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    19 embryo 12-14hr    18 embryo 14-16hr    48 embryo 16-18hr    75 embryo 18-20hr    72 embryo 20-22hr    64 embryo 22-24hr    56 larva L1    77 larva L2    147 larva L3 12hr old    120 larva L3 puffstage 1-2    101 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    135 white prepupae new    263 white prepupae 12hr    392 white prepupae 24hr    285 pupae 2d postWPP    233 pupae 3d postWPP    84 pupae 4d postWPP    90 adult male 01day    84 adult male 05day    84 adult male 30day    87 adult female 01day    196 adult female 05day    227 adult female 30day    240 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    96 embryonic 1182-4H    37 embryonic GM2    106 embryonic Kc167    89 embryonic S1    64 embryonic S3    62 leg disc CME L1    75 wing disc CME-W2    78 wing disc ML-DmD8    40 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    68 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    34 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4  (96) embryonic 1182-4H  (37) embryonic GM2  (106) embryonic Kc167  (89) embryonic S1  (64) embryonic S3  (62) leg disc CME L1  (75) wing disc CME-W2  (78) wing disc ML-DmD8  (40) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (78) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (72) eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (83) mixed discs ML-DmD4-c1  (68) CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2  (50) tumorous blood cells mbn2  (34) ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    96 embryonic 1182-4H    37 embryonic GM2  106 embryonic Kc167    89 embryonic S1    64 embryonic S3    62 leg disc CME L1    75 wing disc CME-W2    78 wing disc ML-DmD8    40 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    68 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    34 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    96 embryonic 1182-4H    37 embryonic GM2    106 embryonic Kc167    89 embryonic S1    64 embryonic S3    62 leg disc CME L1    75 wing disc CME-W2    78 wing disc ML-DmD8    40 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    68 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    34 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    96 embryonic 1182-4H    37 embryonic GM2    106 embryonic Kc167    89 embryonic S1    64 embryonic S3    62 leg disc CME L1    75 wing disc CME-W2    78 wing disc ML-DmD8    40 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    68 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    34 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4  (96) embryonic 1182-4H  (37) embryonic GM2  (106) embryonic Kc167  (89) embryonic S1  (64) embryonic S3  (62) leg disc CME L1  (75) wing disc CME-W2  (78) wing disc ML-DmD8  (40) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (78) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (72) eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (83) mixed discs ML-DmD4-c1  (68) CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2  (50) tumorous blood cells mbn2  (34) ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    96 embryonic 1182-4H    37 embryonic GM2  106 embryonic Kc167    89 embryonic S1    64 embryonic S3    62 leg disc CME L1    75 wing disc CME-W2    78 wing disc ML-DmD8    40 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    68 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    34 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    96 embryonic 1182-4H    37 embryonic GM2    106 embryonic Kc167    89 embryonic S1    64 embryonic S3    62 leg disc CME L1    75 wing disc CME-W2    78 wing disc ML-DmD8    40 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    78 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    68 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    34 ovary fGS/OSS    10 ovary OSC    15 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    17 heat shock, 4-day adult    66 Cadmium 50 mM 6 hrs, larvae L3    108 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    63 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    94 Ethanol 5% 3 hrs, larvae L3    92 Ethanol 10% 3 hrs, larvae L3    78 Caffeine 1.5 mg/ml 4 hrs, larvae L3    91 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    67 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    113 Rotenone 8 μg 12 hrs, larvae L3    137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (40) cold shock, 4-day adult    17 heat shock, 4-day adult  (66) Cadmium 50 mM 6 hrs, larvae L3  (108) Cadmium 50 mM 12 hrs, larvae L3  (73) Cadmium 50 mM 48 hrs, 4-day adult  (81) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3  (63) Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3  (28) Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3  (94) Ethanol 5% 3 hrs, larvae L3  (92) Ethanol 10% 3 hrs, larvae L3  (78) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (91) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (86) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (67) Paraquat 10 mM 48 hrs, 4-day adult  (96) Rotenone 2 μg 12 hrs, larvae L3  (113) Rotenone 8 μg 12 hrs, larvae L3  (137) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    17 heat shock, 4-day adult    66 Cadmium 50 mM 6 hrs, larvae L3  (108) Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    63 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    94 Ethanol 5% 3 hrs, larvae L3    92 Ethanol 10% 3 hrs, larvae L3    78 Caffeine 1.5 mg/ml 4 hrs, larvae L3    91 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    67 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3  (113) Rotenone 8 μg 12 hrs, larvae L3  (137) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    17 heat shock, 4-day adult    66 Cadmium 50 mM 6 hrs, larvae L3    108 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    63 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    94 Ethanol 5% 3 hrs, larvae L3    92 Ethanol 10% 3 hrs, larvae L3    78 Caffeine 1.5 mg/ml 4 hrs, larvae L3    91 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    67 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    113 Rotenone 8 μg 12 hrs, larvae L3    137 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    17 heat shock, 4-day adult    66 Cadmium 50 mM 6 hrs, larvae L3    108 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    63 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    94 Ethanol 5% 3 hrs, larvae L3    92 Ethanol 10% 3 hrs, larvae L3    78 Caffeine 1.5 mg/ml 4 hrs, larvae L3    91 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    67 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    113 Rotenone 8 μg 12 hrs, larvae L3    137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (40) cold shock, 4-day adult    17 heat shock, 4-day adult  (66) Cadmium 50 mM 6 hrs, larvae L3  (108) Cadmium 50 mM 12 hrs, larvae L3  (73) Cadmium 50 mM 48 hrs, 4-day adult  (81) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3  (63) Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3  28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3  (94) Ethanol 5% 3 hrs, larvae L3  (92) Ethanol 10% 3 hrs, larvae L3  (78) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (91) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (86) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (67) Paraquat 10 mM 48 hrs, 4-day adult  (96) Rotenone 2 μg 12 hrs, larvae L3  (113) Rotenone 8 μg 12 hrs, larvae L3  (137) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    17 heat shock, 4-day adult    66 Cadmium 50 mM 6 hrs, larvae L3  108 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    63 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    94 Ethanol 5% 3 hrs, larvae L3    92 Ethanol 10% 3 hrs, larvae L3    78 Caffeine 1.5 mg/ml 4 hrs, larvae L3    91 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    67 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3  113 Rotenone 8 μg 12 hrs, larvae L3  137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    40 cold shock, 4-day adult    17 heat shock, 4-day adult    66 Cadmium 50 mM 6 hrs, larvae L3    108 Cadmium 50 mM 12 hrs, larvae L3    73 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    63 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    94 Ethanol 5% 3 hrs, larvae L3    92 Ethanol 10% 3 hrs, larvae L3    78 Caffeine 1.5 mg/ml 4 hrs, larvae L3    91 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    67 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    113 Rotenone 8 μg 12 hrs, larvae L3    137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD41062 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000454 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9285-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Dip-BEY00740 viable, with Scer\GAL4pnr-MD237 Dip-BGD1317 Sterility Allele fertile Dip-BEY00740 Other Phenotypes Allele electrophoretic variant Dip-B4 Dip-B6 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Dip-B Class Mutagen Stocks Known lesion Dip-Bd06483 P-element activity 1 -- Dip-BEY00740 P-element activity 1 -- Dip-B4 natural population 0 -- Dip-B6 natural population 0 -- Dip-BloNC25 loss of function allele natural population 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dip-B Class Mutagen Stocks Known lesion Dip-BGD1317 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dip-BNIG.9285R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)293γ5 (Jarman and Collett, 1998) Df(3R)Exel6170 (Ryder, 2004.4.26) Df(3R)red3l (Jarman and Collett, 1998) Df(3R)urd (Jarman and Collett, 1998)
Not disrupted in	Df(3R)293γ7 (Jarman and Collett, 1998) Df(3R)l26c (Jarman and Collett, 1998) Df(3R)M36 (Jarman and Collett, 1998) Df(3R)M49 (Jarman and Collett, 1998) Df(3R)red-P1 (Jarman and Collett, 1998) Df(3R)red-P52 (Jarman and Collett, 1998) Df(3R)su(Hw)7 (Jarman and Collett, 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1317} NA P{NIG.9285R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Dip-BEY00740 NA P{XP}Dip-Bd06483 NA miscellaneous insertions P{SUPor-P}KG05128 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
dipeptidyl-peptidase activity inferred from direct assay (Laurie-Ahlberg, 1982) tripeptidyl-peptidase activity inferred from direct assay (Laurie-Ahlberg, 1982)
Biological Process
CV term Evidence References
proteolysis inferred from direct assay (Laurie-Ahlberg, 1982)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
aminopeptidase activity inferred from sequence or structural similarity with EMBL:AF061738 (FlyBase, 1992-) manganese ion binding inferred from electronic annotation with InterPro:IPR011356 (FlyBase Curators et al., 2004-) metalloexopeptidase activity inferred from electronic annotation with InterPro:IPR011356 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR011356 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dip-B - AnxB9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dip-B - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dip-B - CG18518 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Dip-B - CG5445 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Dip-B - DhpD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dip-B - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dip-B - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dip-B - Sec22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dip-B - Tgt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dip-B allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71397 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000454 DroID - A comprehensive database of gene and protein interactions. • FBgn0000454 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48450
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69ZZ7V Dipteran inclusive ortholog search EOG6MPHZD Insect inclusive ortholog search EOG690657 Arthropod inclusive ortholog search EOG64TMQ3 Metazoa inclusive ortholog search EOG6K6TXF
Orthologs in Drosophila Species (EOG69ZZ7V)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dip-B     Drosophila simulans   Dsim\GD18934 Y   Drosophila sechellia   Dsec\GM24136 Y   Drosophila erecta   Dere\GG19841 Y   Drosophila yakuba   Dyak\GE26302 Y   Drosophila ananassae   Dana\GF18621 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21669 Y   Drosophila persimilis   Dper\GL23475 Y   Drosophila willistoni   Dwil\GK14202 Y   Drosophila virilis   Dvir\GJ14485 Y   Drosophila mojavensis   Dmoj\GI23169 Y   Drosophila grimshawi   Dgri\GH14277 Y
Orthologs in non-Drosophila Dipterans (EOG6MPHZD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002978   Anopheles gambiae Malaria mosquito  Agam\AGAP003475   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009825
Orthologs in non-Dipteran Insects (EOG690657)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50527   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005714   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12221   Atta cephalotes Leafcutter ant  Acep\ACEP20318   Atta cephalotes Leafcutter ant  Acep\ACEP25003   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14511   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13338   Linepithema humile Argentine ant  Lhum\LH21189   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25764   Solenopsis invicta Red fire ant  Sinv\SINV10196   Bombyx mori Silkmoth  Bmor\BGIBMGA001803   Pediculus humanus Human body louse  Phum\PHUM432710   Tribolium castaneum Red flour beetle  Tcas\TC012824
Orthologs in non-Insect Arthropods (EOG64TMQ3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_301437   Ixodes scapularis Deer tick  Isca\ISCW003100
Orthologs in non-Arthropod Metazoa (EOG6K6TXF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\W07G4.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022944gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011369gn   Danio rerio Zebrafish  Drer\zgc:152830
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18934 Drosophila sechellia Dsec\GM24136 Drosophila erecta Dere\GG19841 Drosophila yakuba Dyak\GE26302 Drosophila ananassae Dana\GF18621 Drosophila pseudoobscura pseudoobscura Dpse\GA21669 Drosophila persimilis Dper\GL23475 Drosophila willistoni Dwil\GK14202 Drosophila virilis Dvir\GJ14485 Drosophila mojavensis Dmoj\GI23169 Drosophila grimshawi Dgri\GH14277
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20098 y1 w67c23; P{EPgy2}Dip-BEY00740
Harvard	- P{XP}Dip-Bd06483
VDRC	v6296 w1118; P{GD1317}v6296 v6297 w1118; P{GD1317}v6297/TM3
Genomic Clones ( 1 )
	BACR30G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 176 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD41062
Other clones	DPiM_LD41062
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02684 AT05087 AT13129 GH02467 GH05261 GH07193 GH16241 GH16995 GH17248 GH17593 GH18236 GH21488 GM13168 GM29012 LD09787 LD21530 LD23167 LD24663 LD25995 LD30588 LD37079 LD37082 LD46403 LP01641 LP01714 LP02474 LP03501 LP05629 LP06409 LP09761 LP10109 LP10742 LP17045 LP21382 LP23462 RE02348 RE06795 RE07130 RE26814 RE59668 RE73869 RE74640 RH02519 RH04236 RH15427 RH35110 RH46782 RH53417 RH62620 RH63732 RH74592 SD07793 SD17918
Other clones	31253 40003 62238 108325 177774 192843 Dmel_dig_004053_0658_2198 Dmel_dig_008062_0658_1133 Dmel_dig_008476_0702_0532 Dmel_dig_008808_0603_1093 Dmel_dig_012776_0704_1446 Dmel_dig_014256_0584_3224 Dmel_dig_017354_0595_3155 Dmel_dig_017854_0583_2039 Dmel_neb_012216_0916_1974 Dmel_neb_012781_0605_0700 Dmel_neb_013262_0077_2859 Dmel_neb_013680_0116_2309 Dmel_neb_013694_0877_2753 Dmel_neb_013775_0377_1018 Dmel_neb_014707_0449_1177 Dmel_neb_014730_0447_1577 EC22037 EC26806 EC36490 EC051185 EC052733 EC053219 EC053696 EC055861 EK063309 EK140428 EK154023 EK208105 EK234619 EK282640 EK296319 EK298645 EN05406 LD05966 RP004013412 RP004048458 RP004052112 RP004052193 RP004067311 RP004070562 RP004105606 RP004122187 RP004122400 RP004126070 RP004130633 RP004138660 RP004144342 RP004163731 RP004166773 RP004177795 RP004191513 RP004192745 RP004194129 RP004194572 RP004196067 RP004196492 RP004202775 RP004207048 RP004208182 RP004208666 RP004214193 RP004215836 RP004217216 RP004218110 RP004221360 RP004223287 RP004223460 RP004224129 RP004227270 RP004233979 RP004239698 RP004243591 RP004246815 RP004246861 RP004247149 RP004247320 RP004247426 RP004249112 RP004249228 RP004251762 RP004251824 RP004259304 RP004261717 RP004261778 RP004262952 RP004265757 RP004268467 RP004269267 RP004307549 RP004344405 RP004344582 RP004351262 RP004359744 RP004371963 RP004386689 RP004416272 RP004418730 RP004427627 RP004434693 RP004440523 RP004450316 RP004462399 RP004462412 RP004472270 RP004477573 RP004488147 RP004495888 RP004505401 RP004522304 RP004523587 RP004535327 RP004536052 RP004538321 RP004542634 UUGC0813
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000454 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48450
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dip-B CG9285 (Collett, 2002.4.9)
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and increased expression in ClkJrk background. (Claridge-Chang et al., 2001) A screen to identify modifiers for the dipeptidase locates them on the X, second and third chromosomes. (Hiraizumi et al., 1993) Larvae of genetically different lines were reared under varying levels of osmotic stress to study the genetic basis of the correlation of peptidase activities in response to environmental challenge. (Hiraizumi et al., 1992) The developmental variation and tissue locations of Dip-A and Dip-B are determined. (Hall, 1988) Examination of D.melanogaster lines revealed genetic variation of Dip-A and Dip-B within sets of lines that only differed in the second or third chromosome. Experiments were undertaken to identify the types of activity modifiers that may be polymorphic in natural populations and to characterize the genetic organization of the modifiers. (Hiraizumi and Laurie, 1988) Dip-B activity is high in postembryonic stages, the activity in the adult is proportional to gene dosage. (Hall, 1986) Structural gene for dipeptidase B (DIP-B), which is virtually monomorphic in natural populations but which differs in electrophoretic mobility from dipeptidase-B variants in D.simulans. Substrate specificities determined (Laurie-Ahlberg, 1982).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142061 NM_169557 NM_169558 RefSeq (Proteins) • NP_650318 NP_731863 NP_731864 DDBJ / EMBL / GenBank • AAF54991 AAK93350 AAN13593 AAN13594 AI514526 AY051926 CL705860 CZ475158 Entrez Gene - A searchable database of RefSeq genes. • 48450 UniProtKB/TrEMBL • Q9VFQ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M17, leucyl aminopeptidase, C-terminal (IPR000819) Leucine aminopeptidase/peptidase B (IPR011356) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD41062
Linkouts
	BioGRID - A database of protein and genetic interactions • 71397 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000454 DroID - A comprehensive database of gene and protein interactions. • FBgn0000454 DRSC - Results from RNAi screens. • FBgn0000454 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000454 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9285-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000454 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48450 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48450 modMine - Data generated by the modENCODE project. • FBgn0000454
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG9285 (Pile et al., 2003, Claridge-Chang et al., 2001, Savard et al., 2006, Riedl et al., 2005, Cammarato et al., 2011) DipB (Hall, 1986, Galindo et al., 2007) Dip-B (Laurie-Ahlberg, 1982, Deng et al., 2009, Martin et al., 2007, Wasbrough et al., 2010, Riedl et al., 2005, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Dipeptidase B (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0038184
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 1 )
	Sebald et al., 2012, PLoS ONE 7(8): e43144 CHD1 Contributes to Intestinal Resistance against Infection by P. aeruginosa in Drosophila melanogaster. [FBrf0219215] Show all research papers ...