FlyBase Gene Report: Dmel\Dl

embryonic/larval anterior midgut

mesectoderm

(Vaessin et al., 1987)

neuroblast

(Vaessin et al., 1987)

proctodeum

(Vaessin et al., 1987)

adult optic lobe

(Vaessin et al., 1987)

(Vaessin et al., 1987)

embryonic/larval hindgut

(Vaessin et al., 1987)

peripheral nervous system

(Vaessin et al., 1987)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

procephalic neurogenic region

(Haenlin et al., 1990)

embryonic stomatogastric nervous system

(Haenlin et al., 1990)

embryonic stage 9 -- 11

(Haenlin et al., 1990)

photoreceptor cell R3

(Parks et al., 1995)

photoreceptor cell R6

(Parks et al., 1995)

morphogenetic furrow

(Parks et al., 1995)

photoreceptor cell R7

(Parks et al., 1995)

photoreceptor cell R1

(Parks et al., 1995)

(Parks et al., 1995)

photoreceptor cell R4

(Parks et al., 1995)

embryonic stage 13 -- 17

organism | pair rule expression pattern

(Haenlin et al., 1990)

embryonic stage 7

(Haenlin et al., 1990)

embryonic stage 8 -- 11

ventral neurectoderm

(Haenlin et al., 1990)

embryonic stage 5 -- 6

organism | 60-90% egg length

Comment: 65-85% egg length

(Haenlin et al., 1990)

organism | 40-70% egg length

Comment: 40-65% egg length

(Haenlin et al., 1990)

organism | 20-40% egg length

Comment: 20-35% egg length

(Haenlin et al., 1990)

organism | 0-20% egg length

Comment: 5-15% egg length

(Haenlin et al., 1990)

embryonic stage 11 -- 17

presumptive embryonic/larval peripheral nervous system

(Haenlin et al., 1990)

embryonic stage 4 -- 13

inclusive hindgut primordium

(Haenlin et al., 1990)

embryonic stage 10 -- 17

ventral midline | precursor

(Haenlin et al., 1990)

embryonic stage 11 -- 12

anterior midgut primordium

(Haenlin et al., 1990)

neuroblast

(Haenlin et al., 1990)

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

embryonic central brain glial cell

(Fisher et al., 2012)

embryonic ganglion mother cell

(Fisher et al., 2012)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

lateral cord glial cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

longitudinal visceral muscle primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

procephalic neuroblast

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

presumptive embryonic/larval central nervous system

(Vaessin et al., 1987)

stomatogastric nervous system

(Vaessin et al., 1987)

sense organ

(Vaessin et al., 1987)

(Vaessin et al., 1987)

stomodeal ganglion

(Vaessin et al., 1987)

trachea

(Vaessin et al., 1987)

ventral neurectoderm

(Vaessin et al., 1987)

embryonic stage 7 -- 8

cell

• cytoplasm

(Kopczynski and Muskavitch, 1992)

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

embryonic stage 15

segment border muscle

(Figeac et al., 2010)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

organism

(Kopczynski et al., 1988)

Additional Descriptive Data

Excised Dl introns accumulate in two foci in the nucleus.

(Kopczynski and Muskavitch, 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

(Vaessin et al., 1987)

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

cell body rind of medulla

(Choi et al., 2008)

(Morante et al., 2011)

pupal stage

larval outer optic anlage | restricted

(Morante et al., 2011)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

photoreceptor cell R2

(Parks et al., 1995)

photoreceptor cell R8

(Parks et al., 1995)

(Kooh et al., 1993)

photoreceptor cell R5

(Parks et al., 1995)

photoreceptor cell R7

(Parks et al., 1995)

photoreceptor cell R1

(Parks et al., 1995)

morphogenetic furrow

(Parks et al., 1995, Kooh et al., 1993)

peripodial epithelium

(Kooh et al., 1993)

photoreceptor cell R6

(Parks et al., 1995)

morphogenetic furrow | anterior to

(Parks et al., 1995, Kooh et al., 1993)

photoreceptor cell R4

(Parks et al., 1995)

photoreceptor cell R3

(Parks et al., 1995)

(Kooh et al., 1993)

ommatidial precursor cluster

• intracellular

(Overstreet et al., 2003)

antennal disc

(Kooh et al., 1993)

eye disc posterior to the morphogenetic furrow

(Kooh et al., 1993)

lamina anlage | faint

(Wang et al., 2011)

larval outer optic anlage | restricted

(Morante et al., 2011)

larval stage

macrochaeta | precursor

(Kooh et al., 1993)

ventral midline

(Kooh et al., 1993)

wing hair | presumptive

(Kooh et al., 1993)

glial cell

(Kooh et al., 1993)

cone cell

(Kooh et al., 1993)

photoreceptor cell

(Kooh et al., 1993)

scutum | presumptive

(Kooh et al., 1993)

larval inner optic anlage | precursor

(Kooh et al., 1993)

larval outer optic anlage | precursor

(Kooh et al., 1993)

sensory mother cell of wing disc

(Kooh et al., 1993)

larval stage & pupal stage

(Kooh et al., 1993)

adult stage & oogenesis

nurse cell

(Bender et al., 1993)

follicle cell

(Bender et al., 1993)

germarium region 3

(Bender et al., 1993)

oocyte

(Bender et al., 1993)

germarium region 2

(Bender et al., 1993)

germarium region 1

(Bender et al., 1993)

embryonic/larval anterior midgut

(Kooh et al., 1993)

mesectoderm

(Kooh et al., 1993)

embryonic/larval pharynx

(Kooh et al., 1993)

embryonic/larval dorsal trunk

(Kooh et al., 1993)

precursor cell of the stomatogastric nervous system

(Kooh et al., 1993)

embryonic/larval proventriculus

(Kooh et al., 1993)

(Kooh et al., 1993)

ventral neurectoderm

(Kooh et al., 1993)

amnioproctodeal invagination

(Kooh et al., 1993)

embryonic/larval lateral trunk

(Kooh et al., 1993)

embryonic/larval hindgut

(Kooh et al., 1993)

embryonic optic lobe primordium

(Kooh et al., 1993)

neurogenic region

(Kooh et al., 1993)

embryonic/larval labral segment sense organ | precursor

(Kooh et al., 1993)

anterior midgut primordium

(Kooh et al., 1993)

procephalic neurogenic region

(Kooh et al., 1993)

ventral nerve cord

(Kooh et al., 1993)

antenno-maxillary complex

(Kooh et al., 1993)

prepupal stage

microchaeta

(Parks et al., 1997)

macrochaeta

(Kooh et al., 1993)

sensory mother cell of microchaeta

(Parks et al., 1997)

proneural cluster of microchaeta

(Parks et al., 1997)

pre-blastoderm stage

(Kooh et al., 1993)

second instar larval stage

visceral mesoderm | surrounding

(Kooh et al., 1993)

wing disc

(Milan et al., 2004)

embryonic stage 11

(Stute et al., 2004)

fusion competent cell | surrounding

(Stute et al., 2004)

first instar larval stage

adult stage & oogenesis stage S11

(Kooh et al., 1993)

centripetally migrating follicle cell

(Bender et al., 1993)

pupal stage P6

myoblast

(Gildor et al., 2012)

myotube

(Gildor et al., 2012)

anterior crossvein

Comment: 23-26 hr APF

(Conley et al., 2000)

posterior crossvein

Comment: 23-26 hr APF

(Conley et al., 2000)

first instar larval stage -- third instar larval stage

adult midgut progenitor cell

(Mathur et al., 2010)

second instar larval stage -- third instar larval stage

midgut imaginal island

(Mathur et al., 2010)

prepupal stage P3

wing vein | precursor

(Kooh et al., 1993)

wing hair

(Kooh et al., 1993)

wing vein L3 | precursor

(Kooh et al., 1993)

sensillum campaniformium of wing vein L3 | precursor

(Kooh et al., 1993)

second instar larval stage -- late third instar larval stage

optic lobe neuroepithelial cell of larval inner optic anlage

(Wang et al., 2011)

optic lobe neuroepithelial cell of larval outer optic anlage

(Wang et al., 2011)

late third instar larval stage

adult optic lobe neuron of medulla

Comment: newly generated, not mature, neurons

(Wang et al., 2011)

medulla

(Wang et al., 2011)

intestinal stem cell of posterior adult midgut epithelium

(Ohlstein and Spradling, 2007)

embryonic/larval ileum | ventral

(Ma et al., 2013)

prepupal stage P3 -- pupal stage P6

wing vein

(Conley et al., 2000)

embryonic stage 16

(Soplop et al., 2012)

embryonic stage 13

embryonic hindgut | ventral

(Nakamura et al., 2013)

embryonic stage 12 -- 14

embryonic cardioblast

(Grigorian et al., 2011)

adult stage | female & oogenesis

egg chamber | ubiquitous

(Wang et al., 2007)

Additional Descriptive Data

Dl protein is present on myogenic cell membranes.

(Gildor et al., 2012)

Expression of Dl is widespread in the mesoderm at embryonic stage 12. By the end of the period, it becomes restricted to cardioblasts. Based on cell size and shape and the expression levels of Dl, dorsal and ventral subdomains within the cardiogenic mesoderm of stage 12 embryos can be distinguished. Cells of the ventral domain are small and express moderate levels of Dl and tin. Dorsally, larger cells expressing higher levels of tin are observed. Dl expression is highly dynamic in the dorsal domain. At most timepoints during stage 12, anterior and posterior clusters of strongly Dl-positive cells are seen, flanking a central cluster with lower Dl levels. The central cluster expresses eve. eve expression defines a dorso-central cluster from which the pair of eve-positive pericardial cells is specified. The later eve-positive/low-Dl dorso-central cluster gives rise to a dorsal muscle. The anterior and posterior, high-Dl clusters form the definitive cardiogenic mesoderm. They will give rise to the cardioblasts of the dorsal vessel and the odd-positive blood progenitors and pericardial nephrocytes. The ventral domain showing low levels of tin and Dl contribute to the dorsal musculature. Individual lineages derived from the cardiogenic mesoderm segregate from each other and begin to differentiate during the second half of stage 12. The anterior and posterior high-Dl cluster of each segment move closer together, while the central, low-Dl cluster moves out of the way, migrating laterally and ventrally. Dl expression becomes restricted to the cardioblasts. In the thoracic segments, each of the high-Dl clusters forms two cardioblasts while in the abdominal segments, three cardioblasts arise per cluster. However, only two cells of each abdominal cluster maintain a high level of Dl and tin. The third cell down-regulates these genes and expresses svp. A pattern of alternating sets of four tin/Dl-positive and two svp-positive cardioblasts characteristic of the abdominal dorsal vessel is generated.

(Grigorian et al., 2011)

The expression of ey, ap, and Dll were compared in outer optic lobes (OPC) starting in late third instar larvae. At this stage they were expressed as three distinct cell populations. In anterior sections, the three genes are expressed a three parallele stripes of cells that represent rows of neurons that emerge from the OPC. They correspond to progeny from the youngest to oldest neuroblasts. In middle sections, Dll-positive cells are generated in the progeny of the oldest neuroblasts, with ey-positive and ap-positive cells often placed below Dll-positive (in cells that had emerged earlier from the these neuroblasts). By the beginning of pupation, the number of cells origination from the OPC increased. A major reorganization of optic lobe structure occurs around P20 such that the three stripes are no longer distinguishable and the three cell populations are extensively interspersed within the adult medulla cortex.

(Morante et al., 2011)

Dl protein is strongly expressed in neuroepithelial cells of the inner and outer optic anlagen (IPC, OPC) from late second to late third instar larval stages. In the OPC, Dl immunoreactivity is stronger in the medial neuroepithelial cells that border the medulla neuroblasts. Dl protein expression is detected at a lower level in medulla neuroblasts, but is higher in newly generated medulla neurons; however it is not detected in mature medulla neurons or their axons. Dl protein is weakly expressed in the lamina anlage, and in anterior cells in the lamina; it is more strongly expressed as punctate dots in posterior lamina cells.

(Wang et al., 2011)

Dl protein is observed primarily in intracellular vesicles in eye discs though some cytoplasmic staining is seen in cells within the morphogenetic furrow.

(Mathur et al., 2010, Parks et al., 1995)

Dl protein is localized to the segment boundaries of all leg segments in leg discs.

(Greenberg and Hatini, 2009)

Dl protein is used as a marker for the embryonic ventral large intestine.

(Maeda et al., 2007)

Dl protein is expressed in presumptive wing veins in the wing disc.

(Mohit et al., 2006)

Dl protein is expressed in the invaginating ectodermal cells of the keyhole structure of the developing embryonic proventriculus. Dl protein is downregulated in the anterior- and posterior-most cell rows of the keyhole structure after embryonic stage 15.

(Fuss et al., 2004)

Dl is expressed along the ventral side of the DV boundary and along the longitudinal veins in the ventral compartment. Dl is not expressed in dorsal cells.

(Milan et al., 2004)

At embryonic stage 11, Dl protein expression is observed in cells surrounding the cells of visceral mesoderm, in particular in the cells surrounding the fusion-competent myoblasts.

(Stute et al., 2004)

Dl protein is rapidly internalized and is detected intracellularly in developing eye discs of third instar larvae.

(Overstreet et al., 2003, Tsuda et al., 2002)

Well defined staining of crossveins is observed by 23-26 hr APF.

(Conley et al., 2000)

Dl protein is expressed in all microchaeta proneural cells and microchaeta sensory organ precursors (SOPs) and is expressed dynamically in SOP progeny. Dl expression in microchaeta proneural cells is detected before ac expression.

(Parks et al., 1997)

Dl protein is first detected in cells in the morphogenetic furrow. It is primarily accumulated in vesicles located apically within each cell though some cytoplasmic staining is seen. After cells emerge from the furrow, Dl protein is localized exclusively to vesicles that are primarilly localized apically. In earlier rows, Dl protein accumulates in vesicles in R8, R2 and R5. Subsequently, Dl protein disappears from those cells and is seen only in R3 and R4 by row 5. Between rows 6 and 8, vesicles are also observed in R1 and R6 and three rows later, vesicles are apparent in R3, R4, R1, R6, and R7. Dl protein ceases to accumulate in R3, R1, and R6, but continues to be found in R4 and R7 until at least row 14.

(Parks et al., 1995)

Dl protein can be detected throughout oogenesis. It is first detected in the germarium where diffuse cytoplasmic staining and small bright vesicular staining is observed. In stages 1-3, diffuse cytoplasmic staining is again seen. Dl protein accumulates in vesicular features associated with the membranes of nurse cells and oocytes starting in stages 4-5. In stages 5-6, intense staining is observed at the junction between the follicle cells and the nurse cells and oocyte. Dl protein is also apparent in the membranes surrounding the ring canals. By stages 7-8, Dl protein levels fall to background at the membranes at the junction of the oocyte and follicle cells but remain high at the junctions of nurse cells and follicle cells. uring stages 9 and 10A, Dl protein accumulation becomes reduced in the follicle cell, nurse cell, and oocyte membranes and becomes more pronounced in vesicles. Starting in stage 10B-11, Dl protein appears to be transferred to the oocyte from the nurse cells. It is also expressed in a subset of centripetally migrating follicle cells. From stage 11 on, it is expressed at background levels throughout the follicle except at the nurse cell-oocyte border. N protein and Dl protein localization were compared during oogenesis. In the germarium, cytoplasmic N and Dl protein staining are observed. In contrast to Dl protein, more intense N staining is seen in the membranes of follicle cells in regions 2 and 3 of the germarium. Diffuse cytoplasmic staining of N and Dl proteins is bserved in stages 1-6. In contrast to Dl protein, follicle cell membrane staining of N protein is observed during this whole period. In stages 4-5, N and Dl protein accumulation is apically polarized within the membranes of all follicle cells but some N protein is also present in the basal membranes. N and Dl protein staining is also observed in nurse cell membranes and cytoplasm but the membrane staining is stronger for Dl protein than N protein. By stages 7-8, in contrast to Dl protein, N protein is still present in the membranes between oocytes and follicle cells. N protein is expressed in the membranes of all follicle cells that surround the egg chamber in stages 7-9. From stage 9, N protein accumulation decreases in follicle cell membranes but persists in urse cell membranes. N protein also accumulates in two specialized groups of follicle cells situated dorsolaterally at the nurse cell chamber-oocyte junction which eventually form the chorionic appendages. No Dl accumulation is seen in these cells. While Dl protein appears to be transferred from nurse cells to the oocyte during stage 11, N protein is not transferred.

(Bender et al., 1993)

Dl protein is first detected in the cortical membrane of precellular blastoderm embryos. Just before gastrulation, the level of Dl protein decreases in the presumptive mesoderm region of the embryo and profuse vesicular subcellular staining is observed. These vesicles are associated with endocytosis from the membrane. Dl protein is expressed in the ectodermal cells within the neurogenic region and in mesectodermal cells through the waves of neuroblast segregation. Dl protein is not apparent in the segregated neuroblasts but continues to be expressed in the developing epidermis. It is expressed transiently in the mesoderm at the end of neuroblast segregation and is also detected in the procephalic neurogenic region and withinndodermal derivatives including the anterior and posterior midgut invaginations and part of the hindgut. By stage 11, expression is mainly restricted to the developing epidermis and the posterior midgut. During germ band retraction, Dl protein is expressed in a number of tissues including what appears to be the primordia of the optic lobes, the stomatogastric nervous system or antennomaxillary complex, and the epiphysis. It is also expressed in the tracheal trunks, proventriculus, hindgut, pharynx, proesophageal ganglion, and anterior and posterior midguts. It\'s expression in the ventral nerve cord appears to be restricted to dividing cells both in the midline and in the CNS. In larvae, Dl expression is observed in a number of tissues. Dl protein is expressed in CNS neuroblasts andtheir progeny in all three larval instars and within the developing proliferation centers. It is also expressed in cells along the ventral midline that may be glial. In eye discs, Dl protein expression is first seen on the surfaces of unpatterned cells ahead of the morphogenetic furrow. It is then observed in clusters of cells in the morphogenetic furrow and extending behind the furrow. Expression appears to be restricted to apical vescicles (thought to be multivesicular bodies) near the center of each developing ommatidium. The Dl-expressing cells appear to include the photoreceptor cells. Later Dl protein is expressed in cone cells and in the peripodial membrane. Dl expression is also observed in the antennal portion of the eye-antennal disc. A complex pattern of Dl protein epression is described in the wing disc. Dl expression is observed in nearly all cells of the wing disc but at an elevated level in some areas. These include two bands of cells flanking the anterior wing margin that give rise to sensory organ precursors. Two bands of cells flanking the posterior wing margin also express elevated levels of dl protein and may give rise to non-innervated epidermal hairs. In the notum regions, cells that express elevated Dl protein levels appear to correspond to macrochaeta proneural groups. Six hours after puparium formation, Dl protein is expressed in regions where developing bristles are forming along the anterior wing margin, where epidermal hairs are forming along the posterior wing margin, and within the presumptive wing veins. Two groups of intnsely staining cells in the third longitudinal vein correspond to the developing campaniform sensilla. Finally Dl and N expression are compared in the larval CNS, wing discs, and eye-antennal discs.

(Kooh et al., 1993)

Marker for

embryonic large intestine

(Maeda et al., 2007)

intestinal stem cell of posterior adult midgut epithelium

(Ma et al., 2013, Bardin et al., 2010, Choi et al., 2008)

(Chen et al., 2016)

presumptive wing vein

(Cook et al., 2004)

wing vein

(Conley et al., 2000)

Subcellular Localization

CV Term

Evidence

References

apical cortex

inferred from direct assay

(Le Borgne et al., 2005)

cell surface

inferred from direct assay

(Kim et al., 2010, Rawlins et al., 2003)

cytoplasmic vesicle

inferred from direct assay

(Commisso and Boulianne, 2007)

colocalizes_with cytoplasmic vesicle

inferred from direct assay

(Jafar-Nejad et al., 2005)

early endosome

inferred from direct assay

(Rawlins et al., 2003)

endocytic vesicle

inferred from direct assay

(Parks et al., 2006)

endosome

inferred from direct assay

(Coumailleau et al., 2009)

integral component of membrane

inferred from direct assay

(Ahimou et al., 2004)

plasma membrane

inferred from direct assay

(Commisso and Boulianne, 2007, Bernard et al., 2006, De Renzis et al., 2006, Overstreet et al., 2003, Fehon et al., 1990)

Expression Deduced from Reporters

Reporter: Mi{PT-GFSTF.1}Dl^{MI04868-GFSTF.1}

Stage

Tissue/Position (including subcellular localization)

Reference

(Nagarkar-Jaiswal et al., 2015)

Reporter: P{GawB}Dl^05151-G

Stage

Tissue/Position (including subcellular localization)

Reference

adult midgut progenitor cell

(Zhai et al., 2015, Buchon et al., 2010, Zeng et al., 2010)

larval stage

(Zeng et al., 2010)

Reporter: P{GawB}Dl^NP0677

Stage

Tissue/Position (including subcellular localization)

Reference

mushroom body dorsal paired medial cell

(Flybrain Neuron Database et al., 2018.6.28, Tanaka et al., 2008)

mushroom body alpha-lobe

(Tanaka et al., 2008)

mushroom body beta-lobe

(Tanaka et al., 2008)

pedunculus of adult mushroom body

(Tanaka et al., 2008)

adult mushroom body gamma-lobe

(Tanaka et al., 2008)

adult mushroom body beta'-lobe

(Tanaka et al., 2008)

adult mushroom body alpha'-lobe

(Tanaka et al., 2008)

intestinal stem cell of posterior adult midgut epithelium

(Foronda et al., 2014)

larval central brain

(Olson et al., 2019)

mesothoracic tergum primordium

(Olson et al., 2019)

eye-antennal disc

(Olson et al., 2019)

antennal disc

(Olson et al., 2019)

(Olson et al., 2019)

wing hinge primordium

(Olson et al., 2019)

wing pouch | restricted

(Olson et al., 2019)

compartment boundary of wing disc

Comment: described as "A/P or D/V boundary" by authors

(Olson et al., 2019)

Reporter: P{GMR24H06-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

(Guo et al., 2013)

adult midgut region R3a

(Guo et al., 2013)

adult midgut region R3b

(Guo et al., 2013)

Reporter: P{lacW}1282

Stage

Tissue/Position (including subcellular localization)

Reference

photoreceptor cell | precursor

(Fanto et al., 2000)

wing vein | presumptive

(Vervoort et al., 1999)

eye disc posterior to the morphogenetic furrow

(Vervoort et al., 1999)

(Fanto et al., 2000)

Reporter: P{lacW}Dl^S049520

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval heart

(Salzberg et al., 1997)

ventral nerve cord | medial

(Salzberg et al., 1997)

(Salzberg et al., 1997)

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S092611b

Stage

Tissue/Position (including subcellular localization)

Reference

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S105314

Stage

Tissue/Position (including subcellular localization)

Reference

presumptive embryonic/larval peripheral nervous system

embryonic/larval heart

(Salzberg et al., 1997)

(Salzberg et al., 1997)

(Salzberg et al., 1997)

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S111909

Stage

Tissue/Position (including subcellular localization)

Reference

presumptive embryonic/larval peripheral nervous system

(Salzberg et al., 1997)

(Salzberg et al., 1997)

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S130403

Stage

Tissue/Position (including subcellular localization)

Reference

presumptive embryonic/larval nervous system

embryonic/larval heart

(Salzberg et al., 1997)

(Salzberg et al., 1997)

(Salzberg et al., 1997)

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S142311

Stage

Tissue/Position (including subcellular localization)

Reference

organism | ubiquitous

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S144011

Stage

Tissue/Position (including subcellular localization)

Reference

organism | ubiquitous

(Salzberg et al., 1997)

Reporter: P{lacW}Dl^S148011b

Stage

Tissue/Position (including subcellular localization)

Reference

presumptive embryonic/larval central nervous system

(Salzberg et al., 1997)

embryonic head

(Salzberg et al., 1997)

Reporter: P{lArB}Dl^A326.2F3

Stage

Tissue/Position (including subcellular localization)

Reference

wing disc

(Klein and Martinez Arias, 1998)

(de Celis et al., 1997)

ventral thoracic disc

(Bishop et al., 1999)

pupal stage

wing vein

(de Celis et al., 1997)

second instar larval stage

(de Celis et al., 1997)

wing disc

(Klein and Martinez Arias, 1998)

pupal stage -- adult stage

leg

(Bishop et al., 1999)

Reporter: P{PZ}Dl⁰⁵¹⁵¹

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

(Poernbacher et al., 2012)

adult brain | restricted

(Vosshall, 1998.8.10)

adult central complex

(Vosshall, 1998.8.10)

imaginal disc

(Meister and Braun, 1995.10)

embryonic/larval trachea

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dl

View exonic expression by tissue for Dmel\Dl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000463

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000463

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3619-RB;CG3619-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3619

Flygut - An atlas of the Drosophila adult midgut

FBgn0000463

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dl

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 350 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 80 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dl

Transgenic constructs containing regulatory region of Dl

Deletions and Duplications ( 26 )

Duplicated in

Dp(3;1)O5

(Hu et al., 1995)

Dp(3;3)bxd¹¹⁰

(Hukriede et al., 1997, de Celis et al., 1993)

Dp(3;3)MKRS-D2

(de la Concha et al., 1988)

Dp(3;3)P47

(Craymer, 1984)

Disrupted in

Df(3R)BSC475

(Christensen et al., 2008.4.15)

Df(3R)BSC850

(Christensen et al., 2009.7.22)

Df(3R)bxd110

(Alton et al., 1988, Tearle and Nusslein-Volhard, 1987, Jurgens et al., 1984)

Df(3R)Cha9

(Alton et al., 1988)

Df(3R)Dl12

(Kopczynski and Muskavitch, 1992, Alton et al., 1988)

Df(3R)Dl-A143

(Vassin and Campos-Ortega, 1987)

Df(3R)Dl-BX12

(Pepple et al., 2007, Spradling et al., 1999, Szeged Stock Center, 1998-, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Alton et al., 1988)

Df(3R)Dl-FX3

(Campos-Ortega and Haenlin, 1992, Cabrera, 1990, Vassin and Campos-Ortega, 1987)

Df(3R)Dl-HD28

(Alton et al., 1988)

Df(3R)Dl-M2

(Alton et al., 1988)

Df(3R)Dl-X43

(Verheyen et al., 1996, Tearle and Nusslein-Volhard, 1987, Vassin and Campos-Ortega, 1987)

Df(3R)H^KX2

(Maier et al., 1992)

Df(3R)MRS

(Muller et al., 1999)

Df(3R)S485

(Muller et al., 1999)

In(3LR)Dl-KX12

(Vassin and Campos-Ortega, 1987)

In(3R)Dl^B

(Vassin and Campos-Ortega, 1987)

In(3R)Dl^KX15

(Vassin and Campos-Ortega, 1987)

In(3R)Dl^Sp

(Vassin and Campos-Ortega, 1987)

Tp(3;3)Dl^II13

(Vassin and Campos-Ortega, 1987)

Not disrupted in

Df(3R)Cha1a

(Alton et al., 1988)

Df(3R)Cha7

(Alton et al., 1988)

Not duplicated in

Dp(3;3)bxd¹⁰⁰

(de la Concha et al., 1988)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

Dl^9P

lethal

lethal (with Df(3R)Dl-BX12)

Dl^S144011

lethal | heat sensitive

lethal | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

lethal | neurogenic phenotype | recessive

lethal | non-rescuable maternal effect | recessive | heat sensitive

Dl^RF

lethal | recessive | heat sensitive

lethal - all die before end of embryonic stage | neurogenic phenotype

Dl^6B

lethal - all die before end of embryonic stage | neurogenic phenotype | recessive | heat sensitive

Dl^6B

lethal - all die before end of embryonic stage | recessive

lethal - all die before end of P-stage, with Scer\GAL4^klu-G410

Dl^UAS.cDa

lethal - all die before end of P-stage, with Scer\GAL4^ptc-559.1

Dl^UAS.cHa

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Dl^GD14459

partially lethal

Dl^sup4

partially lethal - majority die, with Scer\GAL4^bap.3

Dl^UAS.cDa

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Dl^GD146

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

female sterile | heat sensitive

Dl^6B

female sterile | recessive

Dl^BX8

female sterile | recessive | heat sensitive

Dl^RF

Other Phenotypes

Allele

body color defective

Dl¹

body color defective | dominant

cell shape defective | somatic clone | third instar larval stage

Dl^RevF10

decreased cell number, with Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

Dl^GD2642

decreased cell number | adult stage, with Scer\GAL4^ple.PU

Dl^UAS.cUa

decreased cell number | third instar larval stage, with Scer\GAL4^c768

Dl^UAS.cUa

decreased cell number | third instar larval stage, with Scer\GAL4^C855a

Dl^UAS.cUa

decreased occurrence of cell division | oogenesis | oogenesis, with Scer\GAL4^{VP16.mat.αTub67C}

Dl^UASp.cJa

flight defective, with Scer\GAL4^Mef2.PR

Dl^GD2642

hyperplasia | adult stage, with Scer\GAL4^ey.PH

Dl^UAS.cDa

hyperplasia | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

increased cell number | adult stage, with Scer\GAL4^ple.PU

Dl^GD2642

increased cell number | adult stage | somatic clone

Dl^RevF10

increased cell number | embryonic stage

increased cell number | third instar larval stage, with Scer\GAL4^ey.PH

Dl^UAS.cDa

increased occurrence of cell division | larval stage, with Scer\GAL4^ptc-559.1

Dl^UAS.cJa

increased occurrence of cell division | larval stage, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4^Bx-MS1096

Dl^UAS.cJa

increased occurrence of cell division | third instar larval stage, with Scer\GAL4^ey.PH

Dl^UAS.cDa

locomotor behavior defective, with Scer\GAL4^ple.PU

Dl^GD2642

long lived, with Scer\GAL4^ple.PU

Dl^GD2642

mitotic cell cycle defective | somatic clone

Dl^RevF10

neuroanatomy defective

Dl^TRiP.cUa

neuroanatomy defective, with Scer\GAL4^elav.PLu

Dl^Stu.UAS

neuroanatomy defective, with Scer\GAL4^sca-537.4

Dl^{M619S.K620R.H2N.UAS}

neuroanatomy defective | adult stage, with Scer\GAL4^ato.3.6

Dl^D.UAS

neuroanatomy defective | adult stage, with Scer\GAL4^ple.PU

neuroanatomy defective | embryonic stage

Dl^unspecified

neuroanatomy defective | embryonic stage | heat sensitive

Dl^RF

neuroanatomy defective | larval stage (with Dl^6B)

Dl^RF

neuroanatomy defective | larval stage (with Dl^RF)

Dl^6B

neuroanatomy defective | neurogenic phenotype, with Scer\GAL4^- :

Dl^EP3816.A

neuroanatomy defective | somatic clone

Dl^9P

pain response defective | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dl^GD2642

planar polarity defective, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

planar polarity defective, with Scer\GAL4^ey.PH

Dl^UAS.cDa

planar polarity defective, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

planar polarity defective | somatic clone

Dl^RevF10

short lived, with Scer\GAL4^ple.PU

Dl^UAS.cUa

size defective | adult stage, with Scer\GAL4^ey.PH

Dl^UAS.cDa

size defective | adult stage, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

size defective | dominant

Dl^RevF10

size defective | larval stage, with Scer\GAL4^ptc-559.1

Dl^UAS.cJa

size defective | somatic clone, with Scer\GAL4^Tub.PU

Dl^UAS.cUa

size defective | third instar larval stage, with Scer\GAL4^ey.PH

Dl^UAS.cDa

some die during embryonic stage | neurogenic phenotype

Dl^6B

some die during embryonic stage | recessive | heat sensitive

Dl^6B

some die during pharate adult stage, with Scer\GAL4^klu-G410

Dl^UAS.cDa

some die during pharate adult stage, with Scer\GAL4^ptc-559.1

Dl^UAS.cHa

some die during pupal stage

Dl^9K

tumorigenic | adult stage, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

tumorigenic | adult stage | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

tumorigenic | adult stage | somatic clone, with Scer\GAL4^Ubx.PdC

Dl^UAS.cJa

tumorigenic | larval stage, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

visible

visible, with Scer\GAL4^A9

Dl^{S.UAS.Tag:MYC}

visible, with Scer\GAL4^Act5C.PI

visible, with Scer\GAL4^bs-1348

visible, with Scer\GAL4^dpp.blk1

visible, with Scer\GAL4^Eq1

Dl^UAS.cDa

visible, with Scer\GAL4^ey.PH

Dl^UAS.cDa

visible, with Scer\GAL4^ey.PU

Dl^UAS.cDa

visible, with Scer\GAL4^GMR.PF

Dl^UAS.cUa

visible, with Scer\GAL4^hs.2sev

Dl^{S.UAS.Tag:MYC}

visible, with Scer\GAL4^kni.L2

Dl^UAS.cUa

visible, with Scer\GAL4^{l(3)31-1-31-1}

visible, with Scer\GAL4^lz-gal4

Dl^UAS.cUa

visible, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^ptc-559.1

Dl^UAS.cHa

visible, with Scer\GAL4^sca-109-68

visible, with Scer\GAL4^sca-537.4

Dl^UAS.cDa

visible, with Scer\GAL4^sca-C253

Dl^D.UAS

visible, with Scer\GAL4^T113

Dl^{S.UAS.Tag:MYC}

visible, with Scer\GAL4^Ubx.PdC

visible, with Scer\GAL4^vg.int2.1

Dl^{S.UAS.Tag:MYC}

visible (with Dl^9P)

Dl^RF

visible (with Dl^RF)

Dl^9P

visible | adult stage

visible | adult stage, with Scer\GAL4^dpp.PU

Dl^UAS.cUa

visible | adult stage | dominant, with Scer\GAL4^- :

Dl^EP3816.A

visible | dominant | heat sensitive

Dl^55k

visible | homeotic, with Scer\GAL4^ey.PB

Dl^D.UAS

visible | recessive

visible | recessive | heat sensitive

visible | recessive | somatic clone

Dl^M1

visible | somatic clone

visible | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

wild-type

Phenotype manifest in

Allele

abdominal tergite marginal bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

aCC neuron

Dl³

adult heart | heat sensitive, with Scer\GAL4^tin.CΔ4, Scer\GAL80^ts.αTub84B

Dl^D.UAS

adult midgut

Dl^RevF10

adult posterior midgut epithelium | somatic clone

Dl^RevF10

adult thoracic sensillum

Dl^9P

antenna | ectopic, with Scer\GAL4^ey.PB

Dl^D.UAS

anterior notopleural bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

anterior postalar bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

anterior scutellar bristle

Dl^RevF10

anterior scutellar bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

anterior supraalar bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

basal cylinder

Dl^FE32

basal cylinder, with Scer\GAL4^ap-md544

Dl^UAS.cDa

basal cylinder (with Dl^bl5)

Dl^blX59

basal cylinder (with Dl^blX59)

Dl^bl5

border follicle cell, with Scer\GAL4^slbo.2.6

Dl^D.UAS

border follicle cell | heat sensitive (with Dl^6B)

Dl^RF

border follicle cell | heat sensitive (with Dl^RF)

Dl^6B

cell-cell adherens junction & dorsal mesothoracic disc, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

chaeta, with Scer\GAL4^pnr-MD237

chaeta | supernumerary, with Scer\GAL4^pnr-MD237

chemosensory ventral triple row bristle

Dl^RevF10

cone cell

Dl^TM.sev

cone cell | heat sensitive

cone cell | pupal stage, with Scer\GAL4^GMR.PF

Dl^UAS.cJa

cone cell | supernumerary

Dl^UAS.cHa

crossvein

crystal cell | larval stage | heat sensitive, with Scer\GAL4^hs.PB

Dl^UAS.cDa

denticle belt

dMP2 neuron

Dl³

dMP2 neuron | ectopic | germline clone

dMP2 neuron | somatic clone

Dl^9P

dopaminergic PPL1 neuron | adult stage, with Scer\GAL4^ple.PU

Dl^UAS.cUa

dopaminergic PPL1 neuron | adult stage | supernumerary, with Scer\GAL4^ple.PU

Dl^GD2642

dopaminergic PPM1 neuron | adult stage, with Scer\GAL4^ple.PU

Dl^UAS.cUa

dopaminergic PPM1 neuron | adult stage | supernumerary, with Scer\GAL4^ple.PU

Dl^GD2642

dopaminergic PPM2 neuron | adult stage, with Scer\GAL4^ple.PU

Dl^UAS.cUa

dopaminergic PPM2 neuron | adult stage | supernumerary, with Scer\GAL4^ple.PU

Dl^GD2642

dopaminergic PPM3 neuron | adult stage, with Scer\GAL4^ple.PU

Dl^UAS.cUa

dopaminergic PPM3 neuron | adult stage | supernumerary, with Scer\GAL4^ple.PU

Dl^GD2642

dorsal acute muscle | ectopic

Dl^X

dorsal acute muscle | ectopic | precursor

Dl^X

dorsal cluster neuron, with Scer\GAL4^ato.3.6

Dl^D.UAS

dorsal hair | embryonic stage

dorsal triple row

Dl^RevF10

dorsal-ventral compartment boundary of the wing disc

Dl^RevF10

dorsal-ventral compartment boundary of the wing disc, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

embryonic/first instar larval cuticle | ventral

egg chamber

Dl^BX8

egg chamber, with Scer\GAL4^upd1-E132

Dl^UAS.cHa

egg chamber, with Scer\GAL4^{VP16.mat.αTub67C}

Dl^UASp.cJa

egg chamber | cell non-autonomous | germline clone

Dl^M1

egg chamber | germline clone

egg chamber | somatic clone

Dl^M1

embryo

Dl^unspecified

embryonic/larval anterior midgut | embryonic stage

Dl^I79

embryonic/larval central nervous system | germline clone

Dl^RevF10

Dl^RevF10

embryonic/larval corpus cardiacum

Dl^unspecified

embryonic/larval corpus cardiacum | heat sensitive

Dl^RF

embryonic/larval dorsal branch

Dl^6B

embryonic/larval dorsal branch & tracheal tip cell

Dl^6B

embryonic/larval dorsal trunk, with Scer\GAL4^btl.PS

Dl^UAS.cDa

embryonic/larval dorsal trunk & tracheal tip cell, with Scer\GAL4^btl.PS

Dl^UAS.cDa

embryonic/larval dorsal vessel | precursor

Dl^RevF10

embryonic/larval lymph gland | larval stage | heat sensitive, with Scer\GAL4^hs.PB

Dl^UAS.cDa

embryonic/larval neuron, with Scer\GAL4^- :

Dl^EP3816.A

embryonic/larval peripheral nervous system

Dl^RevF10

embryonic/larval peripheral nervous system | germline clone

Dl^RevF10

embryonic/larval somatic muscle

embryonic/larval somatic muscle | germline clone

embryonic cardioblast

Dl^9P

embryonic epidermis

embryonic epidermis | ventral

embryonic hindgut

Dl^B2

embryonic hindgut, with Scer\GAL4^byn-Gal4

embryonic pericardial cell

Dl^9P

embryonic proventriculus

Dl^9P

embryonic proventriculus, with Scer\GAL4^fkh.14-3

Dl^UAS.cJa

exit glial cell

Dl^9Q

external sensory organ precursor cell | embryonic stage

external sensory organ precursor cell IIa | heat sensitive

Dl^RF

external sensory organ precursor cell IIb | ectopic | heat sensitive

Dl^RF

eye, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

eye, with Scer\GAL4^ey.PB

Dl^D.UAS

eye, with Scer\GAL4^ey.PH

eye, with Scer\GAL4^ey.PU

Dl^UAS.cDa

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^hs.2sev

Dl^{S.UAS.Tag:MYC}

eye, with Scer\GAL4^T113

Dl^{S.UAS.Tag:MYC}

eye | heat sensitive

eye | somatic clone

eye | somatic clone, with Scer\GAL4^Tub.PU

Dl^UAS.cUa

eye | somatic clone | heat sensitive

Dl^6B

eye-antennal disc | heat sensitive

Dl^RF

eye disc & neuron

Dl^RevF10

eye disc | dorsal, with Scer\GAL4^bi-omb-Gal4

Dl^D.UAS

eye disc | somatic clone

Dl^RevF10

eye disc | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

eye disc | third instar larval stage, with Scer\GAL4^ey.PH

Dl^UAS.cDa

eye disc | ventral, with Scer\GAL4^bi-omb-Gal4

Dl^D.UAS

eye photoreceptor cell, with Scer\GAL4^hs.2sev

Dl^UAS.cDa

eye photoreceptor cell & eye disc | posterior, with Scer\GAL4^sca-537.4

Dl^{M619S.K620R.H2N.UAS}

eye photoreceptor cell & ommatidium | ectopic

Dl^DN.ro

eye photoreceptor cell | heat sensitive

eye photoreceptor cell | somatic clone

Dl^RevF10

eye photoreceptor cell | somatic clone | heat sensitive

Dl^6B

female germline stem cell, with Scer\GAL4^C587

Dl^ΔICD.UAS

female germline stem cell | germline clone

Dl^RevF10

female germline stem cell | supernumerary, with Scer\GAL4^nos.PG

Dl^UASp.cJa

femur & joint, with Scer\GAL4^klu-G410

Dl^UAS.cDa

filamentous actin & dorsal mesothoracic disc, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

filzkorper

five-cell ommatidial precursor cluster | heat sensitive

Dl^RF

follicle cell

Dl^M

follicle cell, with Scer\GAL4^{VP16.mat.αTub67C}

Dl^UASp.cJa

follicle cell & mitotic cell cycle | germ-line clone | cell non-autonomous

Dl^M1

follicle cell | cell non-autonomous | germline clone

Dl^RevF10

follicle cell | heat sensitive

Dl^RF

follicle cell | somatic clone

fusion competent cell & visceral mesoderm

Dl^B2

genitalia | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

germarium cap cell, with Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

Dl^GD2642

germarium cap cell, with Scer\GAL4^C587

Dl^ΔICD.UAS

germarium cap cell | ectopic | heat sensitive, with Scer\GAL4^hs.PB

Dl^UAS.cDa

germarium cap cell | supernumerary, with Scer\GAL4^nos.PG

Dl^UASp.cJa

germarium cap cell | supernumerary | heat sensitive, with Scer\GAL4^hs.PB

Dl^UAS.cDa

germline cyst | germline clone

Dl^M

germline stem cell, with Scer\GAL4^bab1-Gal4, Scer\GAL80^ts.αTub84B

Dl^GD2642

head | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

hub cell | first instar larval stage

Dl^RF

hub cell | first instar larval stage, with Scer\GAL4^drm.7.1

Dl^JF02867

hub cell | first instar larval stage | supernumerary, with Scer\GAL4^48Y

Dl^UAS.cJa

hub cell | first instar larval stage | supernumerary, with Scer\GAL4^twi.PG

Dl^UAS.cJa

interfollicle cell

Dl^M3

interfollicle cell, with Scer\GAL4^hs.PB

Dl^UAS.cDa

interfollicle cell, with Scer\GAL4^upd1-E132

Dl^UAS.cHa

interfollicle cell | anterior

Dl^M

interfollicle cell | cell non-autonomous | somatic clone

Dl^M3

interfollicle cell | heat sensitive

Dl^RF

interommatidial bristle

interommatidial bristle, with Scer\GAL4^hs.2sev

Dl^{S.UAS.Tag:MYC}

interommatidial bristle, with Scer\GAL4^lz-gal4

Dl^UAS.cUa

interommatidial bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

interommatidial bristle | heat sensitive

interommatidial bristle | somatic clone | heat sensitive

Dl^6B

interommatidial bristle | supernumerary, with Scer\GAL4^GMR.PF

intersegmental nerve | heat sensitive (with Dl^6B)

Dl^vi1

intersegmental nerve | heat sensitive (with Dl^vi1)

Dl^6B

joint

Dl^RevF10

joint, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

joint, with Scer\GAL4^ap-md544

Dl^UAS.cDa

keyhole structure

Dl^9P

lamina anlage (with Dl^6B)

Dl^RF

lamina anlage (with Dl^RF)

Dl^6B

larval outer optic anlage, with Scer\GAL4^c768

Dl^UAS.cUa

larval outer optic anlage, with Scer\GAL4^C855a

Dl^UAS.cUa

larval outer optic anlage (with Dl^6B)

Dl^RF

larval outer optic anlage (with Dl^RF)

Dl^6B

larval outer optic anlage | somatic clone

Dl^RevF10

leg

leg, with Scer\GAL4^Act5C.PI

Dl^UAS.cDa

leg | distal, with Scer\GAL4^ap-md544

Dl^UAS.cDa

leg | distal, with Scer\GAL4^Dll-md23

Dl^UAS.cDa

leg | heat sensitive

Dl^6B

leg | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

leg sensillum | ectopic, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

lens, with Scer\GAL4^GMR.PF

macrochaeta

macrochaeta & scutum

Dl^sup4

macrochaeta | ectopic

Dl^RevF10

macrochaeta | heat sensitive

macrochaeta | somatic clone | heat sensitive

Dl^6B

mechanosensory ventral triple row bristle

Dl^RevF10

medial triple row

Dl^RevF10

medulla, with Scer\GAL4^ato.3.6

Dl^D.UAS

medulla anlage, with Scer\GAL4^c768

Dl^UAS.cUa

medulla anlage, with Scer\GAL4^C855a

Dl^UAS.cUa

medulla anlage (with Dl^6B)

Dl^RF

medulla anlage (with Dl^RF)

Dl^6B

mesothoracic leg sensillum & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

mesothoracic tergum & macrochaeta, with Scer\GAL4^sca-C253

Dl^D.UAS

mesothoracic tergum & sensory organ cell | ectopic, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

metatarsus

Dl^bl5

metatarsus, with Scer\GAL4^dpp.blk1

Dl^UAS.cDa

metatarsus (with Dl⁰⁵¹⁵¹)

Dl^blX59

metatarsus (with Dl^bl5)

Dl^blX59

metatarsus (with Dl^blX59)

metathoracic leg sensillum & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

microchaeta & adult thorax

Dl¹

microchaeta | cell non-autonomous | somatic clone

Dl^9P

microchaeta | ectopic, with Scer\GAL4^Eq1

Dl^UAS.cDa

microchaeta | ectopic | somatic clone

Dl^9P

microchaeta | heat sensitive

microtubule & oocyte

mitotic cell cycle | somatic clone, with Scer\GAL4^unspecified

Dl^UAS.cJa

morphogenetic furrow, with Scer\GAL4^dpp.blk1

Dl^D.UAS

morphogenetic furrow | somatic clone

Dl^RevF10

morphogenetic furrow | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

muscle founder cell & visceral mesoderm

Dl^B2

neuroblast

Dl³

neuroblast NB5-2

Dl^RevF10

neuroblast NB5-2 | germline clone

Dl^RevF10

neuroblast NB7-4

Dl^RevF10

neuroblast NB7-4 | germline clone

Dl^RevF10

neuron & peripheral nervous system

neurosecretory neuron | embryonic stage

Dl^unspecified

nurse cell | heat sensitive

Dl^RF

ocellus

ommatidial precursor cluster | heat sensitive

ommatidium

ommatidium, with Scer\GAL4^hs.2sev

ommatidium, with Scer\GAL4^lz-gal4

Dl^UAS.cUa

ommatidium, with Scer\GAL4^T113

Dl^{S.UAS.Tag:MYC}

ommatidium | somatic clone

ommatidium | somatic clone | heat sensitive

Dl^6B

oocyte

Dl^M

oocyte & pericentriolar material, with Scer\GAL4^hs.PB

Dl^UAS.cDa

oocyte nucleus, with Scer\GAL4¹⁰⁹

Dl^UAS.cDa

oocyte nucleus | germline clone

Dl^M1

ovary

Dl⁹

pCC neuron

Dl³

pericardial cell | ectopic

Dl^X

pericardial cell | ectopic | precursor

Dl^X

peripheral glial cell, with Scer\GAL4^elav.PLu

Dl^Stu.UAS

photoreceptor cell

Dl^sev.PS

photoreceptor cell | supernumerary, with Scer\GAL4^GMR.PF

photoreceptor cell R1

Dl^UAS.cHa

photoreceptor cell R1, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

photoreceptor cell R2, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

photoreceptor cell R2 | somatic clone

Dl^RevF10

photoreceptor cell R3

Dl^RevF10

photoreceptor cell R3, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

photoreceptor cell R4, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

photoreceptor cell R4 | somatic clone

Dl^RevF10

photoreceptor cell R5, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

photoreceptor cell R5 | somatic clone

Dl^RevF10

photoreceptor cell R6

Dl^UAS.cHa

photoreceptor cell R6, with Scer\GAL4^hs.2sev

Dl^UAS.cHa

photoreceptor cell R7

Dl^UAS.cHa

photoreceptor cell R7 | supernumerary | third instar larval stage, with Scer\GAL4^GMR.PF

Dl^UAS.cJa

photoreceptor cell R8

photoreceptor cell R8 | somatic clone

Dl^RevF10

pigment cell

Dl^{S.GMR.Tag:MYC}

pigment cell, with Scer\GAL4^hs.2sev

Dl^{S.UAS.Tag:MYC}

pigment cell, with Scer\GAL4^sv.PJ

Dl^UAS.cUa

pigment cell | somatic clone | heat sensitive

Dl^6B

pigment cell | supernumerary, with Scer\GAL4^GMR.PF

polar follicle cell

Dl^M

polar follicle cell | supernumerary, with Scer\GAL4^neur-P72

Dl^UAS.cHa

posterior crossvein

posterior dorsocentral bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

posterior notopleural bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

posterior postalar bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

posterior scutellar bristle

Dl^RevF10

posterior scutellar bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

posterior supraalar bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cHa

postnotum | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

presumptive embryonic/larval central nervous system

presumptive embryonic/larval peripheral nervous system

presutural bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

pretarsus, with Scer\GAL4^ap-md544

Dl^UAS.cDa

primary pigment cell | heat sensitive

primary pigment cell | supernumerary

Dl^UAS.cHa

principal midgut epithelial cell

Dl^unspecified

pronotum | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

prothoracic leg sensillum & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

proventriculus inner layer primordium

Dl^9P

proventriculus inner layer primordium, with Scer\GAL4^fkh.14-3

Dl^UAS.cJa

proventriculus intermediate layer primordium

Dl^9P

proventriculus intermediate layer primordium, with Scer\GAL4^fkh.14-3

Dl^UAS.cJa

proventriculus outer layer primordium

Dl^9P

rhabdomere

rhabdomere | heat sensitive

RP2 motor neuron

Dl³

RP2 motor neuron | ectopic | germline clone

RP2 motor neuron | somatic clone

Dl^9P

RP2sib neuron

Dl³

RP2sib neuron | germline clone

RP2sib neuron | somatic clone

Dl^9P

scutellar bristle | supernumerary

scutellar bristle | supernumerary, with Scer\GAL4^sca-109-68

Dl^D.UAS

scutum & macrochaeta & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

scutum & macrochaeta | somatic clone

Dl^RevF10

scutum | cell non-autonomous | somatic clone

Dl^9P

scutum | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

secondary neuroblast

Dl^TRiP.cUa

secondary pigment cell | heat sensitive

segment | germline clone

Dl^RevF10

segment border muscle | precursor

Dl^RevF10

sense organ, with Scer\GAL4^sca-109-68

Dl^UAS.cDa

sense organ, with Scer\GAL4^sca-537.4

Dl^UAS.cDa

sensory mother cell

Dl^RevF10

sensory mother cell & filopodium

Dl^RF

sensory mother cell & filopodium, with Scer\GAL4^neur-P72

Dl^UAS.cHa

sensory mother cell | ectopic | somatic clone | third instar larval stage

Dl^RevF10

sensory mother cell | ectopic | somatic clone | third instar larval stage, with Scer\GAL4^{VP16.mat.αTub67C}

Dl^UAS.cLa

sex comb

Dl¹

sex comb (with Dl^blX59)

Dl^FE32

sex comb (with Dl^FE32)

Dl^blX59

sex comb & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

sex comb | ectopic (with Dl^bl5)

Dl^blX59

sex comb | ectopic (with Dl^blX59)

Dl^bl5

stomatogastric nervous system primordium

Dl^9P

tarsal segment

tarsal segment 2

Dl^bl5

tarsal segment 2, with Scer\GAL4^dpp.blk1

Dl^UAS.cDa

tarsal segment 2 (with Dl⁰⁵¹⁵¹)

Dl^blX59

tarsal segment 2 (with Dl^bl5)

Dl^blX59

tarsal segment 2 (with Dl^blX59)

tarsal segment 3

tarsal segment 3 (with Dl⁰⁵¹⁵¹)

Dl^blX59

tarsal segment 3 (with Dl^bl5)

Dl^blX59

tarsal segment 3 (with Dl^blX59)

tarsal segment 4

tarsal segment 4, with Scer\GAL4^ap-md544

Dl^UAS.cDa

tarsal segment 4 (with Dl⁰⁵¹⁵¹)

Dl^blX59

tarsal segment 4 (with Dl^bl5)

Dl^blX59

tarsal segment 4 (with Dl^blX59)

tarsal segment, with Scer\GAL4^ap-md544

Dl^UAS.cDa

tarsal segment, with Scer\GAL4^dpp.blk1

Dl^UAS.cDa

tarsal segment, with Scer\GAL4^klu-G410

Dl^UAS.cDa

tarsal segment & joint, with Scer\GAL4^klu-G410

Dl^UAS.cDa

tarsal segment | heat sensitive

Dl^6B

tarsal segment | somatic clone

Dl^M1

tendon cell

Dl^unspecified

tertiary pigment cell | heat sensitive

thorax & macrochaeta

tibia & joint, with Scer\GAL4^klu-G410

Dl^UAS.cDa

tormogen cell (with Dl^9P)

Dl^RF

tormogen cell (with Dl^RF)

Dl^9P

tracheal branch primordium, with Scer\GAL4^btl.PS

Dl^UAS.cDa

trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

trichogen cell | ectopic (with Dl^9P)

Dl^RF

trichogen cell | ectopic (with Dl^RF)

Dl^9P

trichome of the posterior wing margin

Dl^RevF10

U neuron

Dl³

U neuron | ectopic | germline clone

Usib neuron

Dl³

Usib neuron | germline clone

ventral nervous system

Dl^unspecified

ventral thoracic disc, with Scer\GAL4^ptc-559.1

Dl^UAS.cHa

ventral triple row

Dl^RevF10

vMP2 neuron

Dl³

vMP2 neuron | ectopic | germline clone

vMP2 neuron | somatic clone

Dl^9P

wing, with Scer\GAL4^A9

wing, with Scer\GAL4^dpp.blk1

Dl^UAS.cJa

wing, with Scer\GAL4^ptc-559.1

Dl^UAS.cHa

wing, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

wing, with Scer\GAL4^vg.int2.1

wing | adult stage, with Scer\GAL4^dpp.PU

Dl^UAS.cUa

wing | dorsal, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

wing | dorsal, with Scer\GAL4^Ubx.PdC

Dl^UAS.cDa

wing | heat sensitive, with Scer\GAL4^ptc-559.1

Dl^UAS.cDa

wing | somatic clone

wing blade, with Scer\GAL4^dpp.blk1

Dl^ΔICD.UAS

wing blade dorsal compartment, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

wing blade dorsal compartment | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

wing blade dorsal compartment | somatic clone, with Scer\GAL4^Ubx.PdC

Dl^UAS.cJa

wing blade ventral compartment | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

wing disc, with Scer\GAL4^dpp.blk1

Dl^UAS.cDa

wing disc, with Scer\GAL4^ptc-559.1

wing disc | dorsal, with Scer\GAL4^dpp.blk1

Dl^UAS.cDa

wing disc dorsal compartment, with Scer\GAL4^ptc-559.1

Dl^UAS.cJa

wing disc dorsal compartment, with Scer\GAL4^Ser.PGF

Dl^UAS.cJa

wing disc dorsal compartment | larval stage | somatic clone, with Scer\GAL4^Bx-MS1096

Dl^UAS.cJa

wing disc ventral compartment, with Scer\GAL4^ptc-559.1

Dl^UAS.cJa

wing disc ventral compartment | larval stage, with Scer\GAL4^ptc-559.1

Dl^UAS.cJa

wing margin, with Scer\GAL4^bbg-C96

Dl^D.UAS

wing margin | ectopic, with Scer\GAL4^dpp.blk1

Dl^UAS.cJa

wing margin | ectopic, with Scer\GAL4^ptc-559.1

Dl^UAS.cHa

wing margin bristle & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

wing sensillum & trichogen cell, with Scer\GAL4^{l(3)31-1-31-1}

Dl^UAS.cJa

wing vein, with Scer\GAL4^- :

Dl^EP3816.A

wing vein, with Scer\GAL4^34B

Dl^D.UAS

wing vein, with Scer\GAL4^A9

wing vein, with Scer\GAL4^bs-1348

wing vein, with Scer\GAL4^Ubx.PdC

Dl^UAS.cDa

wing vein | adult stage

wing vein | distal

Dl^M1

wing vein | ectopic

wing vein | somatic clone

Dl^RevF10

wing vein L2

wing vein L2, with Scer\GAL4^bs-1348

Dl^UAS.cJa

wing vein L2, with Scer\GAL4^kni.L2

Dl^UAS.cUa

wing vein L2 | distal

Dl³

wing vein L2 | ectopic

Dl^M1

wing vein L2 | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

wing vein L3

wing vein L3, with Scer\GAL4^dpp.blk1

Dl^ΔICD.UAS

wing vein L4

wing vein L4, with Scer\GAL4^bs-1348

Dl^UAS.cJa

wing vein L4 | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

wing vein L5

wing vein L5, with Scer\GAL4^bs-1348

Dl^UAS.cJa

wing vein L5 | distal

Dl³

wing vein L5 | ectopic

Dl^M1

wing vein L5 | somatic clone, with Scer\GAL4^Act5C.PI

Dl^UAS.cJa

Orthologs

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Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DLL1

13 of 15

Yes

Hsap\DLL4

11 of 15

Yes

Hsap\DLL3

2 of 15

Yes

Hsap\JAG1

2 of 15

Hsap\DLK2

1 of 15

Yes

Hsap\JAG2

1 of 15

Hsap\NOTCH4

1 of 15

Hsap\SNED1

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dll1

13 of 15

Yes

Mmus\Dll4

11 of 15

Yes

Mmus\Dll3

2 of 15

Yes

Mmus\Jag1

2 of 15

Mmus\Dlk2

1 of 15

Yes

Mmus\Jag2

1 of 15

Rattus norvegicus (Norway rat) (8)

Rnor\Dll4

10 of 13

Yes

Rnor\Dll1

8 of 13

Yes

Rnor\Dll3

2 of 13

Yes

Rnor\Jag1

2 of 13

Rnor\Dlk2

1 of 13

Yes

Rnor\Jag2

1 of 13

Rnor\Notch4

1 of 13

Rnor\Sned1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\dll1

12 of 12

Yes

Xtro\dlc

6 of 12

Yes

Xtro\dll4

6 of 12

Yes

Xtro\jag1

2 of 12

Xtro\dlk2

1 of 12

Yes

Xtro\jag2

1 of 12

Xtro\sned1

1 of 12

Yes

Danio rerio (Zebrafish) (12)

Drer\dld

13 of 15

Yes

Drer\dll4

11 of 15

Yes

Drer\dla

10 of 15

Yes

Drer\dlb

10 of 15

Yes

Drer\dlc

10 of 15

Yes

Drer\dlk2

1 of 15

Yes

Drer\eys

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\apx-1

3 of 15

Yes

Cele\dsl-4

3 of 15

Yes

Cele\arg-1

2 of 15

Yes

Cele\eat-20

1 of 15

Yes

Cele\F55H12.3

1 of 15

Yes

Cele\lag-2

1 of 15

Yes

Cele\R08E3.1

1 of 15

Yes

Cele\sdz-23

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902GI )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17563

Drosophila persimilis

Dper\GL11971

Drosophila willistoni

Dwil\GK13480

Drosophila virilis

Dvir\GJ24543

Drosophila mojavensis

Dmoj\GI24477

Drosophila grimshawi

Dgri\GH22392

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501JF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17012945

Glossina morsitans

Tsetse fly

Gmor\GMOY010548

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02256

Mayetiola destructor

Hessian fly

Mdes\Mdes009323

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011396

Anopheles gambiae

Malaria mosquito

Agam\AGAP010265

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W033O )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010195

Danaus plexippus

Monarch butterfly

Dple\DPOGS212048-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL013610

Apis florea

Little honeybee

Aflo\2147512451

Apis mellifera

Western honey bee

Amel\GB45005

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21895

Bombus terrestris

Buff-tailed bumblebee

Bter\15211578

Linepithema humile

Argentine ant

Lhum\LH26251

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0003d0

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG001325

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06648

Tribolium castaneum

Red flour beetle

Tcas\TC004114

Pediculus humanus

Human body louse

Phum\PHUM290740

Rhodnius prolixus

Kissing bug

Rpro\RPRC012997

Cimex lectularius

Bed bug

Clec\CLEC025063

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001981

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16259

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02EX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003071

Ixodes scapularis

Black-legged tick

Isca\ISCW013622

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63832.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63294.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g02000

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_63051

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07YQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Delta

Ciona intestinalis

Vase tunicate

Cint\delta

Gallus gallus

Domestic chicken

Ggal\DLL4

Gallus gallus

Domestic chicken

Ggal\DLL1

Paralogs

Downloads

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Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

DLL1; delta like canonical Notch ligand 1

3 of 10

C901

2 of 10

wry

2 of 10

crb

1 of 10

cue

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Dl^D.UAS

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

Dl^UAS.cDa

model of cancer

CEA with lola^GS88A8, psq^GS88A8

(Bossuyt et al., 2009, Ferres-Marco et al., 2006)

CEA with ato^{ERD.UAS.Tag:MYC}

(Bossuyt et al., 2009)

CEA with bsk^DN.UAS

(Bossuyt et al., 2009)

CEA with ato^dsRNA.UAS.J

(Bossuyt et al., 2009)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

Dl^HMS01309

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

Dl^9P

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

Dl^D.UAS

DOES NOT ameliorate cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

Dl^RevF10

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^UAS.cHa, Ser^RX82

(Zhan et al., 2013)

Dl^S049520

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

Dl^UAS.cDa

model of cancer

is exacerbated by Not3^KK102144

(De Keersmaecker et al., 2013)

is exacerbated by Not3^KG10496

(De Keersmaecker et al., 2013)

is exacerbated by Not3^GD4068

(De Keersmaecker et al., 2013)

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 15

606582

NEURODEVELOPMENTAL DISORDER WITH NONSPECIFIC BRAIN ABNORMALITIES AND WITH OR WITHOUT SEIZURES; NEDBAS

DLL4; delta like canonical Notch ligand 4

11 of 15

605185

ADAMS-OLIVER SYNDROME 6; AOS6

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Dl - mir-1

immunohistochemistry, luminiscence technology

(Kwon et al., 2005)

protein-protein

Physical Interaction

Assay

References

bead aggregation assay, fluorescence microscopy, inferred by author, atomic force microscopy

(Parks et al., 2006, Ahimou et al., 2004)

Dl - O-fut1

anti tag coimmunoprecipitation, anti tag western blot

(Okajima et al., 2005)

Dl - kuz

protease assay, western blot, inferred by author

(Qi et al., 1999)

Dl - mib1

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study

(Daskalaki et al., 2011, Lai et al., 2005)

Dl - neur

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, enzymatic study

(Liu et al., 2012, Daskalaki et al., 2011, Fontana and Posakony, 2009, Commisso and Boulianne, 2007, Skwarek et al., 2007)

Dl - sca

coimmunoprecipitation, western blot, affinity technology, fluorescence microscopy, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation

(Petruccelli et al., 2018, Mok et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Amun

(Shalaby et al., 2009)

enhanceable

Amun

(Shalaby et al., 2009)

suppressible

aos

(Culi et al., 2001)

enhanceable

aos

(Carmena et al., 2002)

enhanceable

ara

(Barrios et al., 2015)

enhanceable

Atg4b

(Thumm and Kadowaki, 2001)

suppressible

(Bossuyt et al., 2009)

enhanceable

(Bossuyt et al., 2009)

enhanceable

(Bossuyt et al., 2009)

enhanceable

bib

(Doherty et al., 1997)

Dl|mir-7

suppressible

boi

(Da Ros et al., 2013)

enhanceable

boi

(Da Ros et al., 2013)

enhanceable

Bre1

(Bray et al., 2005)

enhanceable

brm

(Armstrong et al., 2005)

enhanceable

(Roch et al., 1998, Klein and Campos-Ortega, 1992)

enhanceable

bsk

(Bossuyt et al., 2009)

enhanceable

(Milan and Cohen, 2000)

enhanceable

caup

(Barrios et al., 2015)

suppressible

CG9650

(Shalaby et al., 2009)

enhanceable

CG9650

(Shalaby et al., 2009)

Dl|mir-7

suppressible

(Da Ros et al., 2013)

enhanceable

(Da Ros et al., 2013)

enhanceable

cic

(Klein and Campos-Ortega, 1992)

enhanceable

CoRest

(Domanitskaya and Schüpbach, 2012)

suppressible

crb

(Richardson and Pichaud, 2010)

enhanceable

CRMP

(Jauffred et al., 2013)

suppressible

Csp

(Shalaby et al., 2009)

enhanceable

(Zhai et al., 2012)

enhanceable

(Zhai et al., 2012)

enhanceable

CycG

(Nagel et al., 2016)

suppressible

Dad

(Ward et al., 2006)

suppressible

dap

(Bossuyt et al., 2009)

suppressible

DCTN1-p150

(Iyadurai et al., 2008)

enhanceable

E(Dl)9P39.3

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)9P39.8

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)D72

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)D165

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)F10

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)F14

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)F25

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)F42

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)F167

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)KP254

(Klein and Campos-Ortega, 1992)

enhanceable

E(Dl)KP420

(Klein and Campos-Ortega, 1992)

enhanceable

E(nd)195

(Hing and Artavanis-Tsakonas, 1995)

suppressible

E(z)

(Ferres-Marco et al., 2006)

enhanceable

ebi

(Tsuda et al., 2002)

enhanceable

(Ahmed et al., 2003, Escudero et al., 2003)

suppressible

Egfr

(Diaz-Benjumea and Garcia-Bellido, 1990)

suppressible

emc

(Mari-Beffa et al., 1991)

suppressible

eyg

(Reynolds-Kenneally and Mlodzik, 2005)

enhanceable

Fkbp14

(van de Hoef et al., 2013)

suppressible

fng

(Jacobsen et al., 1998)

enhanceable

fng

(Pitsouli and Delidakis, 2005)

suppressible

(Smylla et al., 2016, Sun and Artavanis-Tsakonas, 1996, Dietrich and Campos-Ortega, 1984, Ives, 1959)

Dl|RpS3

suppressible

(Schultz, 1929)

enhanceable

(Jacobsen et al., 1998)

suppressible

HDAC1

(Ferres-Marco et al., 2006)

suppressible

HERC2

(Imai et al., 2015)

enhanceable

(Da Ros et al., 2013)

Dl|mir-7

suppressible

(Da Ros et al., 2013)

enhanceable

Hipk

(Lee et al., 2009)

suppressible

hop

(Reynolds-Kenneally and Mlodzik, 2005)

enhanceable

Hr38

(Shalaby et al., 2009)

enhanceable

Hs3st-B

(Kamimura et al., 2004)

enhanceable

ihog

(Da Ros et al., 2013)

suppressible

Ilp8

(Garelli et al., 2012)

enhanceable

(Calpena et al., 2018)

suppressible

(Calpena et al., 2018)

suppressible

Jra

(Bossuyt et al., 2009)

enhanceable

Kap-α3

(Sachan et al., 2013)

enhanceable

kst

(Shalaby et al., 2009)

enhanceable

lqf

(Tian et al., 2004)

suppressible

Lrrk

(Imai et al., 2015)

enhanceable

Lrrk

(Imai et al., 2015)

enhanceable

M285

(Go and Artavanis-Tsakonas, 1998)

enhanceable

mib1

(Pitsouli and Delidakis, 2005)

enhanceable

mir-7

(Da Ros et al., 2013)

suppressible

mir-8

(Vallejo et al., 2011)

enhanceable

mirr

(Barrios et al., 2015)

enhanceable

mirr

(Barrios et al., 2015)

enhanceable

Mo25

(He et al., 2005)

suppressible

(Mishra et al., 2001, de Celis and Bray, 2000, Lawrence et al., 2000, Jacobsen et al., 1998, Doherty et al., 1996)

enhanceable

net

(Klein and Campos-Ortega, 1992)

suppressible

neur

(Imai et al., 2015)

enhanceable

neur

(Pitsouli and Delidakis, 2005, Lai and Rubin, 2001)

enhanceable

Neurl4

(Imai et al., 2015)

suppressible

Neurl4

(Imai et al., 2015)

enhanceable

Ni-K

(Klein and Campos-Ortega, 1992)

enhanceable

nmo

(Verheyen et al., 2001)

enhanceable

Not3

(De Keersmaecker et al., 2013)

enhanceable

nvy

(Wildonger and Mann, 2005)

Dl|ct

suppressible

Pi3K92E

(Zhai et al., 2012)

enhanceable

Plexate

(Klein and Campos-Ortega, 1992)

enhanceable

Psn

(van de Hoef et al., 2013, Guo et al., 1999)

enhanceable

(Klein and Campos-Ortega, 1992, Wessendorf et al., 1992)

suppressible

Rbf

(Ferres-Marco et al., 2006)

enhanceable

Rbf

(Ferres-Marco et al., 2006)

Dl|Utx

suppressible

Rbf

(Herz et al., 2010)

enhanceable

RpL9

(Schmidt et al., 1996)

enhanceable

RpL19

(Klein and Campos-Ortega, 1992)

enhanceable

RpS3

(Dietrich and Campos-Ortega, 1984)

enhanceable

rumi

(Acar et al., 2008)

suppressible

(Klein and Campos-Ortega, 1992, Schultz, 1929)

enhanceable

(Pitsouli and Delidakis, 2005)

suppressible

(Pitsouli and Delidakis, 2005)

enhanceable

Sirt1

(Horvath et al., 2016)

enhanceable

smo

(Da Ros et al., 2013)

suppressible

sno

(Coyle-Thompson and Banerjee, 1993)

enhanceable

Snr1

(Marenda et al., 2004)

suppressible

Su(Dl)D107

(Klein and Campos-Ortega, 1992)

suppressible

Su(Dl)F116

(Klein and Campos-Ortega, 1992)

enhanceable

Su(dx)

(Cornell et al., 1999)

suppressible

Su(dx)

(Fostier et al., 1998)

enhanceable

su(f)

(Sinclair et al., 1984)

suppressible

Su(H)

(Jacobsen et al., 1998)

enhanceable

Su(H)

(Fortini and Artavanis-Tsakonas, 1994)

suppressible

Su(var)3-9

(Ferres-Marco et al., 2006)

enhanceable

tsh

(Singh et al., 2004)

enhanceable

uif

(Xie et al., 2012)

suppressible

upd1

(Reynolds-Kenneally and Mlodzik, 2005)

enhanceable

Utx

(Herz et al., 2010)

suppressible

Vha68-2

(Shalaby et al., 2009)

suppressible

Xxylt

(Pandey et al., 2018)

enhanceable

γTub23C

(Mahoney et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

amos

enhanceable

(Villa-Cuesta et al., 2003)

aos

enhanceable

(Carmena et al., 2002)

AP-1μ

suppressible

Dl|Ser

(Benhra et al., 2011)

AP-2α

suppressible

(Song and Lu, 2012)

suppressible

(Klein and Martinez Arias, 1998)

enhanceable

(White and Jarman, 2000)

bib

enhanceable

(Doherty et al., 1997)

Brd

enhanceable

(Leviten and Posakony, 1996)

Bre1

enhanceable

(Bray et al., 2005)

brm

enhanceable

(Armstrong et al., 2005)

Caf1-105

enhanceable

(Yu et al., 2013)

csw

enhanceable

(Oishi et al., 2006)

Dcp-1

enhanceable

(Kim et al., 2010)

Dcr-2|Eogt

suppressible

(Müller et al., 2013)

suppressible

(Christoforou et al., 2008)

enhanceable

(Kucherenko et al., 2008)

dgo

enhanceable

(Weber et al., 2012)

dom

enhanceable

(Kwon et al., 2013)

Dp|E2f1

enhanceable

(Baonza and Freeman, 2005)

dsh

enhanceable

(Fanto and Mlodzik, 1999)

enhanceable

(Fuwa et al., 2006)

Dys

suppressible

(Kucherenko et al., 2008)

E(spl)m8-HLH|N

suppressible

(Shepard et al., 1989)

ebi

enhanceable

(Tsuda et al., 2002)

ebi

suppressible

(Tsuda et al., 2002)

enhanceable

(Ahmed et al., 2003, Escudero et al., 2003)

Egfr

suppressible

(Carmena et al., 2002, Diaz-Benjumea and Garcia-Bellido, 1990)

emc

enhanceable

(Baonza et al., 2000)

emc

suppressible

(Mari-Beffa et al., 1991)

fng

enhanceable

(Dominguez et al., 2004)

enhanceable

(Fanto and Mlodzik, 1999)

Gp150

enhanceable

(Fetchko et al., 2002)

Hipk

enhanceable

(Lee et al., 2009)

l(1)sc

enhanceable

(Rottgen et al., 1998)

lqf

enhanceable

(Tian et al., 2004)

mam

enhanceable

(Alexander et al., 2006, Helms et al., 1999)

mam

suppressible

(Helms et al., 1999)

mys

enhanceable

(Prout et al., 1997)

Myt1

enhanceable

(Price et al., 2002)

enhanceable

(Kuzina et al., 2011, Li et al., 2003, Matsuno et al., 1997, Verheyen et al., 1996)

suppressible

(Lieber et al., 2002, de Celis and Bray, 2000, Lieber et al., 1992, Xu et al., 1990, Siren and Portin, 1989)

nerfin-1

suppressible

(Xu et al., 2017)

neur

enhanceable

(Pitsouli and Delidakis, 2005)

nmo

suppressible

(Verheyen et al., 2001)

Nsf2

suppressible

(Stewart et al., 2001)

Nsf2

enhanceable

(Stewart et al., 2001)

enhanceable

peb

suppressible

(Pickup et al., 2009, Wilk et al., 2004)

peb

enhanceable

(Wilk et al., 2004)

Psn

enhanceable

(Mahoney et al., 2006)

pyd

enhanceable

(Chen et al., 1996)

Rala

enhanceable

(Cho and Fischer, 2011)

Ras85D|sev

suppressible

Dl|tws

(Maixner et al., 1998)

Rbf|rno

enhanceable

(Steele et al., 2009)

Rbf|rno

suppressible

(Steele et al., 2009)

Ret

suppressible

(Read et al., 2005)

enhanceable

(Shamloula et al., 2002)

rno

enhanceable

(Steele et al., 2009)

enhanceable

(Chanut et al., 2000)

rst

enhanceable

(Gorski et al., 2000, Tanenbaum et al., 2000)

rumi

enhanceable

(Acar et al., 2008)

sca

enhanceable

(Hu et al., 1995)

sens

enhanceable

(Pepple et al., 2007)

sens

suppressible

(Pepple et al., 2007)