FlyBase Gene Report: Dmel\Lar

General Information

Symbol

Dmel\Lar

Species

D. melanogaster

Name

Leukocyte-antigen-related-like

Annotation Symbol

CG10443

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000464

Gene Model Status

Current

Stock Availability

38 publicly available

Enzyme Name (EC)

Protein-tyrosine-phosphatase (3.1.3.48)

Gene Snapshot

Leukocyte-antigen-related-like (Lar) encodes a transmembrane receptor tyrosine phosphatase with a extracellular domain that binds to the product of Sdc. It regulates signaling through the product of Abl. While the product of Lar has many functions, it is best known for its roles in embryonic motor axon guidance and in target recognition by axons of R7 photoreceptors. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dlar, bypass

Key Links

Genomic Location

Cytogenetic map

37F2-38A2

Sequence location

2L:19,586,623..19,732,069 [+]

Recombination map

2-54

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES

Protein Family (UniProt)

Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. (P16621)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

protein tyrosine phosphatase activity; SAM domain binding; transmembrane receptor protein tyrosine phosphatase activity

Predictions / Assertions

protein tyrosine phosphatase activity

Catalytic Activity (EC)

Experimental Evidence

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)

Predictions / Assertions

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)

Summaries

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES -: Receptor Protein Tyrosine Phosphatases possess a single transmembrane domain and are localized to the plasma membrane. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).

Protein Function (UniProtKB)

Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325). It controls motor axon guidance (PubMed:8598047). In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674). Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674).

(UniProt, P16621)

Summary (Interactive Fly)

transmembrane - receptor tyrosine kinase functioning to regulate axon guidance

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Lar or the JBrowse view of Dmel\Lar for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 6.03

gene_with_dicistronic_mRNA ; SO:0000722

Gene model reviewed during 5.46

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.44

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.05

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2014)

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Lar-RA

FBtr0081260

NM_078880

7606

2029

Lar-RB

FBtr0112800

NM_165313

8456

2011

Lar-RD

FBtr0305950

NM_001259165

7355

1912

Lar-RF

FBtr0331239

NM_001273665

8424

2032

Lar-RG

FBtr0331240

NM_001273666

8637

1935

Lar-RH

FBtr0331241

NM_001273667

7782

1927

Lar-RI

FBtr0331242

NM_001273668

8494

1941

Additional Transcript Data and Comments

Reported size (kB)

8.2 (northern blot)

(Tian et al., 1991)

7.606 (longest cDNA)

(Streuli et al., 1989)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Lar-PA

FBpp0080801

229.1

2029

7.01

NP_523604

AAF53837

Lar-PB

FBpp0111712

227.4

2011

7.05

NP_724220

AAN11057

Lar-PD

FBpp0297092

216.4

1912

7.14

NP_001246094

AFH03768

Lar-PF

FBpp0303681

229.3

2032

7.01

NP_001260594

AGB93129

Lar-PG

FBpp0303682

218.5

1935

7.09

NP_001260595

AGB93130

Lar-PH

FBpp0303683

217.7

1927

7.04

NP_001260596

AGB93131

Lar-PI

FBpp0303684

219.4

1941

7.01

NP_001260597

AGB93132

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

2029 (aa)

(Streuli et al., 1989)

Comments

External Data

Domain

The extracellular domain (1-1412) is sufficient to inhibit bdl function.

(UniProt, P16621)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lar using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (25 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

protein tyrosine phosphatase activity

inferred from direct assay

(assigned by CACAO )

(Madan et al., 2011)

SAM domain binding

inferred from physical interaction with FLYBASE:ckn; FB:FBgn0033987

(Weng et al., 2011)

inferred from physical interaction with FLYBASE:Liprin-γ; FB:FBgn0034720

(Astigarraga et al., 2010)

transmembrane receptor protein tyrosine phosphatase activity

inferred from direct assay

(Streuli et al., 1989)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

protein tyrosine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000439233

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (18 terms)

Terms Based on Experimental Evidence (17 terms)

CV Term

Evidence

References

axon extension

inferred from mutant phenotype

(Prakash et al., 2009)

axon guidance

inferred from mutant phenotype

(Hofmeyer and Treisman, 2009, Prakash et al., 2009, Berger et al., 2008, Krueger et al., 1996)

axon target recognition

inferred from mutant phenotype

(Astigarraga et al., 2010)

centripetally migrating follicle cell migration

inferred from mutant phenotype

(Barlan et al., 2017)

motor neuron axon guidance

inferred from genetic interaction with FLYBASE:Ptp99A; FB:FBgn0004369, FLYBASE:Ptp10D; FB:FBgn0004370

(Sun et al., 2001)

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Sun et al., 2001)

inferred from mutant phenotype

(Fox and Zinn, 2005, Krueger et al., 1996)

negative regulation of homophilic cell adhesion

inferred from genetic interaction with FLYBASE:bdl; FB:FBgn0028482

(Cameron et al., 2013)

nervous system development

inferred from mutant phenotype

(Krueger et al., 2003)

oogenesis

inferred from mutant phenotype

(Krueger et al., 2003)

peptidyl-tyrosine dephosphorylation

inferred from direct assay

(Streuli et al., 1989)

photoreceptor cell morphogenesis

inferred from mutant phenotype

(Hofmeyer et al., 2006)

positive regulation of filopodium assembly

inferred from mutant phenotype

(Barlan et al., 2017)

positive regulation of plasma membrane bounded cell projection assembly

inferred from mutant phenotype

(Squarr et al., 2016)

R7 cell development

inferred from mutant phenotype

(Hofmeyer and Treisman, 2009, Nern et al., 2008, Hofmeyer et al., 2006)

regulation of axon extension involved in axon guidance

inferred from mutant phenotype

(Prakash et al., 2009)

retinal ganglion cell axon guidance

inferred from mutant phenotype

(Choe et al., 2006)

spermatogenesis

inferred from mutant phenotype

(Yu et al., 2015)

synaptic growth at neuromuscular junction

inferred from mutant phenotype

(Hofmeyer and Treisman, 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

axon guidance

traceable author statement

(Bateman and Van Vactor, 2001)

motor neuron axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN002709377

(assigned by GO_Central )

(Gaudet et al., 2011)

protein dephosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000439233

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

axon

inferred from direct assay

(Jeon et al., 2008)

basal plasma membrane

inferred from direct assay

(Squarr et al., 2016)

cell leading edge

inferred from direct assay

(Barlan et al., 2017)

focal adhesion

inferred from direct assay

(Weng et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Lar transcripts are detected throughout embryogenesis on northern blots and are most abundant in 9-15hr embryos. Lar transcripts are first detected by in situ hybridization in late stage 11 embryos. They are localized to segmentally repeated clusters of cell bodies in the neuronal layer. After germband retraction, Lar transcripts are more homogeneously distributed. High level expression is observed in a pair of cells or cell clusters located near the midline in each segment with lower level expression in many other cell bodies.

(Tian et al., 1991)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunohistochemistry

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval trachea

(Tian et al., 1991)

embryonic stage 12 -- 17

commissure

(Tian et al., 1991)

longitudinal connective

(Tian et al., 1991)

ventral nerve cord

(Tian et al., 1991)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

central nervous system

• cell surface of axon

(Johnson et al., 2004)

spermatogenesis & adult stage | male

male germline cell

(Srinivasan et al., 2012)

male germline stem cell

• plasma membrane | restricted

(Srinivasan et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Dorus et al., 2006)

Additional Descriptive Data

In male germline stem cells, Lar immunofluorescence is localized to the membrane at the interface between the hub and the germline stem cells. Lar was also detected in two- and four-cell spermatogonial cysts, with only a weak signal in eight-cell spermatogonial cysts, where it localized to the membrane between mitotic sister cells of a germline cyst. Lar signal was below detection in cyst progenitor cells, somatic cyst cells, and in germ cells in later stages of differentiation.

(Srinivasan et al., 2012)

Localized Lar protein is first observed in the axonal layer in stage 12 embryos. By stage 14 uniform expression is seen along the commissures and longitudinal connectives. Weaker staining is seen on peripheral axon tracts near the edges of the CNS. Weak tracheal staining is sometimes observed.

(Tian et al., 1991)

Marker for

axon

(Johnson et al., 2004)

Subcellular Localization

CV Term

Evidence

References

axon

inferred from direct assay

(Jeon et al., 2008)

basal plasma membrane

inferred from direct assay

(Squarr et al., 2016)

cell leading edge

inferred from direct assay

(Barlan et al., 2017)

focal adhesion

inferred from direct assay

(Weng et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Lar in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Lar

View exonic expression by tissue for Dmel\Lar

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000464

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10443-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10443

Flygut - An atlas of the Drosophila adult midgut

FBgn0000464

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 37 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 34 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Lar

Transgenic constructs containing regulatory region of Lar

Deletions and Duplications ( 12 )

Not disrupted in

Df(2L)TW1

(Fitzpatrick et al., 1995)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)Exel6044)

lethal (with Lar^5.5)

Lar^13.2

lethal (with Lar^13.2)

lethal (with Lar⁴⁵¹)

Lar²¹²⁷

lethal (with Lar²¹²⁷)

lethal | heat sensitive, with Scer\GAL4^αTub84B.PL

Lar^{dsRNA.UAS.THFC}

lethal | recessive

partially lethal - majority die | recessive

Lar^bypass

viable, with Scer\GAL4^Mef2.PR

Lar^GD14391

viable, with Scer\GAL4^pnr-MD237

Lar^GD14391

viable, with Scer\GAL4^tin.CΔ4

Lar^GD14391

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Lar^HMS00822

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Lar^HMS02186

female sterile

Lar^unspecified

male semi-sterile, with Scer\GAL4^VP16.bam

Lar^{dsRNA.UAS.THFC}

Other Phenotypes

Allele

behavior defective | recessive

cell migration defective | cell autonomous | oogenesis | somatic clone

Lar^13.2

cell migration defective | cell non-autonomous | oogenesis | somatic clone

Lar^13.2

cell migration defective | oogenesis | oogenesis (with Lar^bola1)

Lar^bola2

cell migration defective | oogenesis | oogenesis (with Lar^bola2)

Lar^bola1

neuroanatomy defective

neuroanatomy defective, with Scer\GAL4^elav.PLu

Lar^UAS.cKa

neuroanatomy defective, with Scer\GAL4^elav-C155

Lar^UAS.cKa

neuroanatomy defective (with Lar^5.5)

Lar^13.2

neuroanatomy defective (with Lar^13.2)

Lar^5.5

neuroanatomy defective (with Lar²¹²⁷)

neuroanatomy defective (with Lar^bypass)

Lar²¹²⁷

neuroanatomy defective (with Lar^C12)

Lar²¹²⁷

neuroanatomy defective | adult stage, with Scer\GAL4^Pdf.PU

Lar^UAS.cKa

neuroanatomy defective | adult stage | somatic clone

Lar²¹²⁷

neuroanatomy defective | cell autonomous | pupal stage | somatic clone

neuroanatomy defective | embryonic stage

Lar^5.5

neuroanatomy defective | larval stage, with Scer\GAL4^how-24B, Scer\GAL4^sca.PU

Lar^UAS.cKa

neuroanatomy defective | larval stage (with Lar^5.5)

Lar^13.2

neuroanatomy defective | larval stage (with Lar^13.2)

Lar^5.5

neuroanatomy defective | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Lar^cyto.UAS

neuroanatomy defective | somatic clone

neuroanatomy defective | third instar larval stage (with Lar²¹²⁷)

Lar^C12

neuroanatomy defective | third instar larval stage (with Lar^C12)

Lar²¹²⁷

neuroanatomy defective | third instar larval stage (with Lar^CRISPR.3)

neuroanatomy defective | third instar larval stage (with Lar^CRISPR.13)

Lar^CRISPR.3

neuroanatomy defective | third instar larval stage (with Lar^{MI03443-TG4.1})

Lar^CRISPR.3

neurophysiology defective

optomotor response defective | somatic clone

oxidative stress response defective

Lar^MB03324

size defective | adult stage, with Scer\GAL4^Pdf.PU

Lar^UAS.cKa

visual behavior defective | somatic clone

wild-type

Lar^{GMR.Tag:SS(wg),Tag:HA}

Phenotype manifest in

Allele

abdominal segmental nerve

abdominal segmental nerve, with Scer\GAL4^elav-C155

Lar^UAS.cKa

actin-based cell projection | oogenesis | somatic clone (with Lar^5.5)

Lar^13.2

actin-based cell projection | oogenesis | somatic clone (with Lar^13.2)

Lar^5.5

actin filament & follicle cell | somatic clone | cell non-autonomous

Lar^5.5

anterior fascicle & axon | ectopic

Lar^bypass

anterior fascicle & axon | ectopic (with Lar^5.5)

Lar^13.2

anterior fascicle & axon | ectopic (with Lar^13.2)

Lar^5.5

axon (with Lar²¹²⁷)

Lar^C12

axon (with Lar^C12)

Lar²¹²⁷

axon | adult stage, with Scer\GAL4^Pdf.PU

Lar^UAS.cKa

bouton

bouton | supernumerary, with Scer\GAL4^elav.PLu

Lar^UAS.cKa

bouton | supernumerary, with Scer\GAL4^elav-C155

Lar^UAS.cKa

bouton | supernumerary | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Lar^cyto.UAS

centripetally migrating follicle cell | somatic clone (with Lar^5.5)

Lar^13.2

centripetally migrating follicle cell | somatic clone (with Lar^13.2)

Lar^5.5

class IV dendritic arborizing neuron | third instar larval stage (with Lar^CRISPR.3)

class IV dendritic arborizing neuron | third instar larval stage (with Lar^CRISPR.13)

Lar^CRISPR.3

class IV dendritic arborizing neuron | third instar larval stage (with Lar^{MI03443-TG4.1})

Lar^CRISPR.3

dendritic tree | third instar larval stage (with Lar^CRISPR.3)

dendritic tree | third instar larval stage (with Lar^CRISPR.13)

Lar^CRISPR.3

dendritic tree | third instar larval stage (with Lar^{MI03443-TG4.1})

Lar^CRISPR.3

distal dendrite | third instar larval stage (with Lar^CRISPR.3)

Lar^CRISPR.13

distal dendrite | third instar larval stage (with Lar^CRISPR.13)

Lar^CRISPR.3

dorsal appendage (with Lar^5.5)

Lar^13.2

dorsal appendage (with Lar^13.2)

Lar^5.5

egg

egg | maternal effect (with Lar^5.5)

Lar^13.2

egg | maternal effect (with Lar^13.2)

Lar^5.5

egg chamber

elongation stage spermatid, with Scer\GAL4^VP16.bam

Lar^{dsRNA.UAS.THFC}

eye disc | third instar larval stage (with Lar²¹²⁷)

Lar^C12

eye disc | third instar larval stage (with Lar^C12)

Lar²¹²⁷

follicle cell

follicle cell | cell non-autonomous | somatic clone

Lar^5.5

germarium

Lar^bola2

germarium region 2b

Lar^bola2

germarium region 3

Lar^bola2

intersegmental nerve

intersegmental nerve, with Lar^5.5/Lar^13.2, Scer\GAL4^elav-C155

Lar^C1929S.UAS

intersegmental nerve (with Lar^5.5)

Lar^13.2

intersegmental nerve (with Lar^5.5), with Lar^C1929S.UAS, Scer\GAL4^elav-C155

Lar^13.2

intersegmental nerve (with Lar^13.2)

Lar^5.5

intersegmental nerve (with Lar^13.2), with Lar^C1929S.UAS, Scer\GAL4^elav-C155

Lar^5.5

intersegmental nerve branch ISNb of A1-7 | embryonic stage

Lar^5.5

longitudinal connective

medulla

Lar^unspecified

neuromuscular junction

neuromuscular junction, with Scer\GAL4^elav.PLu

Lar^UAS.cKa

neuromuscular junction, with Scer\GAL4^elav-C155

Lar^UAS.cKa

neuromuscular junction | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Lar^cyto.UAS

NMJ bouton | larval stage, with Scer\GAL4^how-24B, Scer\GAL4^sca.PU

Lar^UAS.cKa

NMJ bouton | larval stage (with Lar^5.5)

Lar^13.2

NMJ bouton | larval stage (with Lar^13.2)

Lar^5.5

NMJ bouton | third instar larval stage (with Lar²¹²⁷)

Lar^C12

NMJ bouton | third instar larval stage (with Lar^C12)

Lar²¹²⁷

oocyte, with Lar^5.5/Lar^13.2, Scer\GAL4^T155

oocyte (with Lar^5.5)

Lar^13.2

oocyte (with Lar^5.5), with Lar^ΔFn2-9.UAS, Scer\GAL4^T155

Lar^13.2

oocyte (with Lar^5.5), with Lar^ΔFn123.UAS, Scer\GAL4^T155

Lar^13.2

oocyte (with Lar^5.5), with Lar^ΔFn456.UAS, Scer\GAL4^T155

Lar^13.2

oocyte (with Lar^13.2)

Lar^5.5

oocyte (with Lar^13.2), with Lar^ΔFn2-9.UAS, Scer\GAL4^T155

Lar^5.5

oocyte (with Lar^13.2), with Lar^ΔFn123.UAS, Scer\GAL4^T155

Lar^5.5

oocyte (with Lar^13.2), with Lar^ΔFn456.UAS, Scer\GAL4^T155

Lar^5.5

oocyte | oogenesis stage S14 (with Lar^5.5)

Lar^13.2

oocyte | oogenesis stage S14 (with Lar^13.2)

Lar^5.5

oocyte associated follicular epithelium (with Lar^bola1)

Lar^bola2

oocyte associated follicular epithelium (with Lar^bola2)

Lar^bola1

oocyte associated follicular epithelium | cell autonomous | somatic clone

Lar^13.2

optic cartridge

Lar²¹²⁷

photoreceptor cell & growth cone | somatic clone

Lar⁴⁵¹

photoreceptor cell | cell autonomous | pupal stage | somatic clone

photoreceptor cell R2 & axon | somatic clone

Lar⁴⁵¹

photoreceptor cell R3 & axon | somatic clone

Lar⁴⁵¹

photoreceptor cell R4 & axon | somatic clone

Lar⁴⁵¹

photoreceptor cell R4 | pupal stage | somatic clone

Lar²¹²⁷

photoreceptor cell R5 & axon | somatic clone

Lar⁴⁵¹

photoreceptor cell R7

photoreceptor cell R7 (with Lar²¹²⁷)

photoreceptor cell R7 (with Lar^bypass)

Lar²¹²⁷

photoreceptor cell R7 (with Lar^C12)

Lar²¹²⁷

photoreceptor cell R7 & axon (with Lar^5.5)

Lar²¹²⁷

photoreceptor cell R7 & axon (with Lar²¹²⁷)

photoreceptor cell R7 & axon (with Lar^C12)

Lar²¹²⁷

photoreceptor cell R7 & axon | somatic clone

photoreceptor cell R7 & growth cone (with Lar^5.5)

Lar²¹²⁷

photoreceptor cell R7 & growth cone (with Lar²¹²⁷)

Lar^5.5

photoreceptor cell R7 & growth cone | somatic clone

Lar²¹²⁷

photoreceptor cell R7 | somatic clone

photoreceptor cell R7 | third instar larval stage (with Lar²¹²⁷)

Lar^C12

photoreceptor cell R7 | third instar larval stage (with Lar^C12)

Lar²¹²⁷

polar follicle cell

polar follicle cell | ectopic

pre-elongation spermatid, with Scer\GAL4^VP16.bam

Lar^{dsRNA.UAS.THFC}

rhabdomere R7 (with Lar²¹²⁷)

Lar^C12

rhabdomere R7 (with Lar^C12)

Lar²¹²⁷

RP1 motor neuron (with Lar^5.5)

Lar^13.2

RP1 motor neuron (with Lar^13.2)

Lar^5.5

RP3 motor neuron (with Lar^5.5)

Lar^13.2

RP3 motor neuron (with Lar^13.2)

Lar^5.5

RP4 motor neuron (with Lar^5.5)

Lar^13.2

RP4 motor neuron (with Lar^13.2)

Lar^5.5

RP5 motor neuron (with Lar^5.5)

Lar^13.2

RP5 motor neuron (with Lar^13.2)

Lar^5.5

s-LNv neuron | adult stage, with Scer\GAL4^Pdf.PU

Lar^UAS.cKa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PTPRD

14 of 15

Yes

Hsap\PTPRF

13 of 15

Yes

Hsap\PTPRS

12 of 15

Yes

Hsap\PTPRC

2 of 15

Hsap\PTPRZ1

2 of 15

Hsap\CSF3R

1 of 15

Yes

Hsap\IL6ST

1 of 15

Yes

Hsap\IL12RB2

1 of 15

Yes

Hsap\IL31RA

1 of 15

Yes

Hsap\LIFR

1 of 15

Yes

Hsap\OSMR

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ptprd

13 of 15

Yes

Mmus\Ptprf

13 of 15

Yes

Mmus\Ptprs

11 of 15

Yes

Mmus\Ptprc

2 of 15

Mmus\Ptprz1

2 of 15

Mmus\Csf3r

1 of 15

Yes

Mmus\Il6st

1 of 15

Yes

Mmus\Il12rb2

1 of 15

Yes

Mmus\Il27ra

1 of 15

Yes

Mmus\Il31ra

1 of 15

Yes

Mmus\Lifr

1 of 15

Yes

Mmus\Osmr

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Ptprt

1 of 15

Mmus\Ptpru

1 of 15

Rattus norvegicus (Norway rat) (15)

Rnor\Ptprf

12 of 13

Yes

Rnor\Ptprs

8 of 13

Yes

Rnor\Ptprd

5 of 13

Yes

Rnor\Ptprc

2 of 13

Rnor\Csf3r

1 of 13

Yes

Rnor\Il31ra

1 of 13

Yes

Rnor\Lifr

1 of 13

Yes

Rnor\Osmr

1 of 13

Yes

Rnor\Ptpra

1 of 13

Rnor\Ptpre

1 of 13

Rnor\Ptprk

1 of 13

Yes

Rnor\Ptprm

1 of 13

Rnor\Ptprt

1 of 13

Yes

Rnor\Ptpru

1 of 13

Rnor\Ptprz1

1 of 13

Xenopus tropicalis (Western clawed frog) (9)

Xtro\ptprd

7 of 12

Yes

Xtro\ptprf

7 of 12

Yes

Xtro\ptprs

6 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (25)

Drer\ptprfb

13 of 15

Yes

Drer\ptprdb

10 of 15

Yes

Drer\ptprfa

8 of 15

Yes

Drer\ptprsa

7 of 15

Yes

Drer\ptprd

6 of 15

Yes

Drer\ptprc

2 of 15

Drer\csf3r

1 of 15

Yes

Drer\il6st

1 of 15

Yes

Drer\il12rb2

1 of 15

Yes

Drer\il12rb2l

1 of 15

Drer\lifrb

1 of 15

Yes

Drer\LOC101884960

1 of 15

Yes

Drer\LOC103911449

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\ptprz1b

1 of 15

Drer\si:ch1073-391i24.1

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\ptp-3

13 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\F55H12.5

1 of 15

Yes

Cele\H06I04.5

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\Y41D4A.5

1 of 15

Cele\Y71G12B.31

1 of 15

Yes

Cele\ZK616.65

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PTP1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\pyp2

1 of 12

Yes

Spom\pyp3

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919006U )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Lar

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA28096

Drosophila persimilis

Dper\GL26255

Drosophila willistoni

Dwil\GK14922

Drosophila virilis

Dvir\GJ13567

Drosophila mojavensis

Dmoj\GI20182

Drosophila grimshawi

Dgri\GH13826

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500DS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17027191

Glossina morsitans

Tsetse fly

Gmor\GMOY006687

Glossina morsitans

Tsetse fly

Gmor\GMOY006735

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13982

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13984

Mayetiola destructor

Hessian fly

Mdes\Mdes010604

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005284

Anopheles darlingi

American malaria mosquito

Adar\ADAC002342

Anopheles gambiae

Malaria mosquito

Agam\AGAP010090

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013413

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013410

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00B2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012049

Danaus plexippus

Monarch butterfly

Dple\DPOGS214816-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS214815-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005707

Heliconius melpomene

Postman butterfly

Hmel\HMEL006336

Apis florea

Little honeybee

Aflo\2147490273

Apis florea

Little honeybee

Aflo\2147565603

Apis mellifera

Western honey bee

Amel\GB41645

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12076

Bombus terrestris

Buff-tailed bumblebee

Bter\15201961

Bombus terrestris

Buff-tailed bumblebee

Bter\15207538

Linepithema humile

Argentine ant

Lhum\LH25880

Linepithema humile

Argentine ant

Lhum\LH20500

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00110c

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004224

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03781

Tribolium castaneum

Red flour beetle

Tcas\TC003342

Pediculus humanus

Human body louse

Phum\PHUM010640

Rhodnius prolixus

Kissing bug

Rpro\RPRC013935

Cimex lectularius

Bed bug

Clec\CLEC005334

Cimex lectularius

Bed bug

Clec\CLEC005333

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002085

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI062519

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10873

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04GF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013125

Strigamia maritima

European centipede

Smar\SMAR013720

Strigamia maritima

European centipede

Smar\SMAR013420

Ixodes scapularis

Black-legged tick

Isca\ISCW020666

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66888.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72534.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66889.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62076.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00770

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_314862

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G11WG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rptpd_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PtprD/F/S

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_026193gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_17

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PtrpfL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Igf_21

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-R/Ptp/Di

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000023098

Ciona intestinalis

Vase tunicate

Cint\LOC100178651

Ciona intestinalis

Vase tunicate

Cint\LOC100177989

Ciona intestinalis

Vase tunicate

Cint\LOC100177056

Ciona intestinalis

Vase tunicate

Cint\LOC100182659

Gallus gallus

Domestic chicken

Ggal\PTPRS

Gallus gallus

Domestic chicken

Ggal\PTPRF

Gallus gallus

Domestic chicken

Ggal\PTPRD

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (9)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Lar^{dsRNA.UAS.THFC}

model of azoospermia

CEA

(Yu et al., 2015)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PTPRD; protein tyrosine phosphatase receptor type D

14 of 15

601598

PTPRF; protein tyrosine phosphatase receptor type F

13 of 15

179590

BREASTS AND/OR NIPPLES, APLASIA OR HYPOPLASIA OF, 2; BNAH2

PTPRS; protein tyrosine phosphatase receptor type S

12 of 15

601576

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Lar

anti tag coimmunoprecipitation, anti tag western blot

(Hofmeyer and Treisman, 2009)

Lar - Abi

pull down, western blot

(Squarr et al., 2016)

Lar - Abl

enzymatic study, autoradiography, pull down, western blot, surface plasmon resonance

(Madan et al., 2011, Wills et al., 1999)

Lar - CadN

anti tag coimmunoprecipitation, western blot

(Prakash et al., 2009)

Lar - InR

enzymatic study, surface plasmon resonance

(Madan et al., 2011)

Lar - Liprin-α

anti tag coimmunoprecipitation, anti tag western blot

(Astigarraga et al., 2010)

Lar - Liprin-γ

anti tag coimmunoprecipitation, anti tag western blot

(Astigarraga et al., 2010)

Lar - Sdc

pull down, enzyme linked immunosorbent assay, affinity technology, inferred by author, tag visualisation

(Johnson et al., 2006, Fox and Zinn, 2005)

Lar - ckn

pull down, anti tag western blot, two hybrid

(Weng et al., 2011)

Lar - dlp

affinity technology, inferred by author, tag visualisation, pull down, enzyme linked immunosorbent assay

(Johnson et al., 2006)

Lar - ena

pull down, western blot, anti tag coimmunoprecipitation, enzymatic study, autoradiography

(Johnson et al., 2006, Wills et al., 1999)

Lar - mys

enzymatic study, surface plasmon resonance

(Madan et al., 2011)

Lar - nerfin-2

enzymatic study, surface plasmon resonance

(Madan et al., 2011)

RNA-RNA

Physical Interaction

Assay

References

Lar - mir-289

luminiscence technology

(Nesler et al., 2013)

Lar - mir-8

luminiscence technology

(Nesler et al., 2013, Hyun et al., 2009)

Lar - mir-958

luminiscence technology

(Nesler et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lar

enhanceable

Abi

(Squarr et al., 2016)

Lar

suppressible

Abl

(Wills et al., 1999)

Lar

suppressible

bdl

(Cameron et al., 2013)

Lar

enhanceable

CadN

(Prakash et al., 2009)

Lar

enhanceable

ckn

(Weng et al., 2011)

Lar

suppressible

ena

(Maurel-Zaffran et al., 2001)

Lar

enhanceable

ena

(Maurel-Zaffran et al., 2001)

Lar

suppressible

Lar::Ptp69D

(Maurel-Zaffran et al., 2001)

Lar

suppressible

Liprin-α

(Hofmeyer et al., 2006, Kaufmann et al., 2002)

Lar

enhanceable

Liprin-α

(Prakash et al., 2009, Hofmeyer et al., 2006)

Lar

enhanceable

mys

(Bateman et al., 2001)

enhanceable

(Poe et al., 2017)

enhanceable

(Kaufmann et al., 1998)

Lar

suppressible

RhoGAP100F

(Holbrook et al., 2012)

Lar

enhanceable

Sdc

(Fox and Zinn, 2005)

Lar

enhanceable

trio

(Maurel-Zaffran et al., 2001, Bateman et al., 2000)

Lar

suppressible

trio

(Holbrook et al., 2012, Maurel-Zaffran et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Abl

suppressible

Lar

(Wills et al., 2002)

bdl

suppressible

Lar

(Cameron et al., 2013)

Liprin-α

enhanceable

Lar

(Hofmeyer et al., 2006)

Liprin-α

suppressible

Lar

(Prakash et al., 2009)

Ptp52F

suppressible

Lar

(Schindelholz et al., 2001)

Ptp69D

suppressible

Lar

(Maurel-Zaffran et al., 2001)

Sara|Sdc

enhanceable

Lar

(Johnson et al., 2006)

Sdc

suppressible

Lar

(Fox and Zinn, 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61235

DroID - A comprehensive database of gene and protein interactions.

FBgn0000464

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35259

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

37F2-38A2

Sequence location

2L:19,586,623..19,732,069 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

37F2-38A2

Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi⁰¹⁰⁶⁸ and P{lacW}l(2)k10239^k10239

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

38A-38A

(determined by in situ hybridisation)

(Krueger et al., 1996, Fitzpatrick et al., 1995)

38A1-38A1

(Saito, 1995.6.23)

36C3-36D2

(determined by in situ hybridisation)

(Streuli et al., 1989)

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-53.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (38)

Bloomington

9149

w^*; P{UAS-Lar.K}P4B

8560

w^*; P{UAS-Lar.cyto}3

63122

w^*; P{UAS-Lar.PPLL}46

8774

w^*; Lar^13.2/CyO

8593

y¹ w^*; P{UAS-Lar.CSX2}28

24058

w¹¹¹⁸; Mi{ET1}Lar^MB03324

25503

w¹¹¹⁸; Mi{ET1}Lar^MB06400

c00471

f06635

v107996

v36270

w¹¹¹⁸ P{GD14391}v36270

v36269

w¹¹¹⁸; P{GD14391}v36269

More stocks available...

Genomic Clones (47)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (299)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

LD45391

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000464

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000464

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35259

Antibody Information

Laboratory Generated Antibodies

polyclonal, monoclonal

(Krueger et al., 2003)

monoclonal

(Sun et al., 2001, Tian et al., 1991)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

9D82B3

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

One or more of the processed

(FlyBase Genome Annotators, 2014)

transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping

(FlyBase Genome Annotators, 2014)

ORFs are represented by Lar (FBgn0000464), CG46244 (FBgn0267964).

(FlyBase Genome Annotators, 2014)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R⁺ cells: cells become round and detached. Kc167 cells are unaffected.

(Kiger et al., 2003)

All detectable in vitro PTPase catalytic activity resides in the membrane-proximal of the two PTPase domains of Lar, PTPase D1. However, function of this domain is not required in transgenes to rescue lethal Lar mutants to viability. One important function of PTPase D2 may be to regulate the PTPase activity of PTPase D1. Both the Ig-like domains and FnIII domains of Lar serve important non-redundant functions. The Ig like domains are required for embryonic neural development and the FnIII domains are essential during oogenesis.

(Krueger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

Lar cooperates with integrins to coordinate actin filaments at the basal surface to the follicular epithelium.

(Bateman et al., 2001)

Lar is required for photoreceptor cell target specificity in the optic lobe.

(Clandinin et al., 2001)

Lar is required in posterior follicle cells to maintain osk localisation in the oocyte. In addition Lar plays an important role in aligning follicle cells actin relative to the polar cells to promote egg elongation along the anterior-posterior axis. lar may interact closely with the extracellular matrix to facilitate the planar polarisation of epithelial layers.

(Frydman and Spradling, 2001)

In Lar mutants, R7 cells initially project to their correct layer, but then retract to the R8 target layer in the optic lobe. This defect can be fully rescued by expression of Lar in R7 and partially rescued by expression of Lar in R8.

(Maurel-Zaffran et al., 2001)

Lar is required for the correct targeting of R7 cell axons. It can act autonomously in R7 and nonautonomously in R8. The phosphatase domains of Lar are required for its activity in R7, but not in R8. This suggests that Lar can act both as a receptor in R7 and as a ligand provided by R8.

(Maurel-Zaffran et al., 2001)

Requirements of Lar, Ptp69D and Ptp99A in growth cone guidance decisions along the ISN and SNb motor pathways demonstrates relationships among the tyrosine phosphatases are complex and dependent on cellular context. At growth cone choice points along one nerve, two phosphatases cooperate, while along another nerve these same phosphatases can act in opposition to one another. Lar is central to ISN guidance, Ptp69D and Ptp99A are not essential but do participate in guidance processes involving Lar.

(Desai et al., 1997)

scw is located between exons 4 and 5 of Lar.

(Krueger et al., 1996)

The product of the Lar gene plays a key role during motoneuron growth cone guidance. Lar controls the ability of certain motor axons to navigate specific choice points in the developing nervous system.

(Krueger et al., 1996)

Spatial and temporal transcript accumulation pattern in ovaries is determined by in situ hybridisation.

(Fitzpatrick et al., 1995)

Receptor linked PTPases may be involved in axon outgrowth and guidance during embryonic development.

(Tian et al., 1991)

Lar is a member of a family of receptor linked protein tyrosine phosphatases.

(Streuli et al., 1989)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 86 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35259

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P16621

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000464

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10443

Flygut - An atlas of the Drosophila adult midgut

FBgn0000464

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35259

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003342

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10443

modMine - A data warehouse for the modENCODE project

FBgn0000464

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

13853-LarKG04810

BioGRID - A database of protein and genetic interactions.

61235

DroID - A comprehensive database of gene and protein interactions.

FBgn0000464

DRSC - Results frm RNAi screens

FBgn0000464

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

9D82B3

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000464

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10443-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0000464

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35259

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG10443

(Guven-Ozkan et al., 2016, Ni et al., 2011.7.19, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Berger et al., 2008, Hughes et al., 2008, Rogers et al., 2003, Morrison et al., 2000)

DLAR

(Nose, 2012, Madan et al., 2011, Tong et al., 2011, Prakash et al., 2009, Madan and Gopal, 2008, Raghava et al., 2008, Shinza-Kameda et al., 2006, Ensslen-Craig and Brady-Kalnay, 2004, Rogers et al., 2003, Rogers et al., 2003, Patel and Van Vactor, 2002, Schindelholz et al., 2001, Stoker, 2001, Suzuki et al., 2001, Chisholm and Tessier-Lavigne, 1999, den Hertog, 1999, Garrity, 1999, Bateman et al., 1998, Chiba and Rose, 1998, Halaby and Mornon, 1998, Kaufmann et al., 1998, Stoker and Dutta, 1998, Van Vactor, 1998, Wills et al., 1998, deLapeyriere and Henderson, 1997, Desai et al., 1997, Desai et al., 1997, Desai et al., 1997, Neel and Tonks, 1997, Sun et al., 1997, Wills et al., 1997, Chiba and Keshishian, 1996, Harsum and Tannahill, 1996, Nieto, 1996, Roush, 1996, Stoker, 1996, Tonks and Neel, 1996, Fitzpatrick et al., 1995, Sells and Chernoff, 1995, Kuma et al., 1993, Oon et al., 1993, Tian et al., 1991, Tian et al., 1991)

DLar

(Petrovic and Hummel, 2008, Muda et al., 2002)

Dlar

(Shearin et al., 2018, Kamimura and Maeda, 2017, Squarr et al., 2016, Biersmith et al., 2011, Williamson et al., 2010, Prakash et al., 2009, Jeon et al., 2008, Nern et al., 2008, Pawson et al., 2008, Conder et al., 2007, Hiesinger et al., 2006, Johnson et al., 2006, Conder et al., 2005, Fox and Zinn, 2005, Govek et al., 2005, Mehta et al., 2005, Johnson et al., 2004, Kuzin et al., 2004, Krueger et al., 2003, Lundquist, 2003, Baran and Jin, 2002, Jin, 2002, Kaufmann et al., 2002, Renfranz and Beckerle, 2002, Schmid et al., 2002, Wills et al., 2002, Baas and Luo, 2001, Bateman and Van Vactor, 2001, Bateman et al., 2001, Chase, 2001, Desai, 2001, Frydman and Spradling, 2001, Lee et al., 2001, Maurel-Zaffran et al., 2001, Reinhard et al., 2001, Schindelholz et al., 2001, Sun et al., 2001, Bateman et al., 2000, Lin and Greenberg, 2000, Luo, 2000, Sun et al., 2000, Andersen, 1999, Bateman and van Vactor, 1999, Frydman and Spradling, 1999, Gallo and Letourneau, 1999, Kunes, 1999, Landgraf et al., 1999, Tear, 1999, Van Etten, 1999, Wills et al., 1999, Frydman and Spradling, 1998, Kaufmann et al., 1998, Van Vactor et al., 1998, Wills et al., 1998, Goodman, 1997, Goodman et al., 1997, Chien, 1996, Krueger et al., 1996, Saito, 1995.9.21, Streuli et al., 1989)

Lar

(Stedden et al., 2019, Lee et al., 2018, Barlan et al., 2017, Hakeda-Suzuki et al., 2017, Liu et al., 2017, Poe et al., 2017, Agrawal and Hardin, 2016, Gene Disruption Project members, 2016-, Guven-Ozkan et al., 2016, Zhang et al., 2016, Hatzihristidis et al., 2015, Hsu et al., 2015, Kavi et al., 2015, Morozova et al., 2015, Yu et al., 2015, Ashwal-Fluss et al., 2014, FlyBase Genome Annotators, 2014, Rudrapatna et al., 2014, Shulman et al., 2014, Sopko et al., 2014, Vernes, 2014, Chen et al., 2013, Harbison et al., 2013, Lee et al., 2013, Ozkan et al., 2013, Gates, 2012, Jordan et al., 2012, Matunis et al., 2012, Rodriguez et al., 2012, Bellen et al., 2011, Gontang et al., 2011, Hadjieconomou et al., 2011, Weng et al., 2011, Astigarraga et al., 2010, Wright et al., 2010, Hofmeyer and Treisman, 2009, Hyun et al., 2009, Viktorinová et al., 2009, Jeon et al., 2008, Kurusu and Zinn, 2008, Petrovic and Hummel, 2008, Dorus et al., 2006, Tsuda et al., 2006, Sun et al., 2001)

PTP38A

(Fitzpatrick, 1995.4.27)

Ptp38A

(Fisher et al., 2008)

dlar

(Ackley and Jin, 2004, Broadie and Richmond, 2002, Arora et al., 1994)

lar

(Nesler et al., 2013, Gontang et al., 2011)

Name Synonyms

LAR receptor tyrosine phosphatase

(Banyai and Patthy, 2004)

Leukocyte-Antigen-Related-Like

(Rudrapatna et al., 2014)

Leukocyte-antigen-related-like

(Harbison et al., 2013, Gates, 2012, Matunis et al., 2012, Khanna et al., 2010)

bypass

(Goodman, 1995, van Vactor et al., 1995)

leukocyte- antigen-related-like

(Yu et al., 2015)

leukocyte-antigen-related-like

(Petrovic and Hummel, 2008)

Secondary FlyBase IDs

FBgn0010057

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Study focus (0)

Experimental Role

Project

Project Type

Title

References (254)

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