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Gene Dmel\DNaseII

General Information
Symbol	Dmel\DNaseII	Species	D. melanogaster
Name	Deoxyribonuclease II	Annotation symbol	CG7780
Feature type	protein_coding_gene	FlyBase ID	FBgn0000477
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	dDNase II
Genomic Location
Chromosome (arm)	3R	Recombination map	3-61.8
Cytogenetic map	90E1-90E1	Sequence location	3R:13,845,097..13,846,883 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Deoxyribonuclease II is referred to in FlyBase by the symbol Dmel\DNaseII (CG7780, FBgn0000477). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: deoxyribonuclease II activity. There is experimental evidence that it is involved in the biological process: nurse cell apoptotic process. 11 alleles are reported. The phenotype of these alleles is annotated with: ovary. It has one annotated transcript and one annotated polypeptide. Protein features are: Deoxyribonuclease II. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1640898_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of DNaseII. Gene sequence location is 3R:13845097..13846883.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	DNase-1: Deoxyribonuclease-1 The structural gene for DNase 1, one of an estimated 7 or more DNase species (Boyd, 1964, Biophys. Biochem. Acta 171: 103-12). Active on native DNA at acid pH (optimum = 4.8) and in the presence of EDTA. Heterozygotes for electrophoretic alleles show two bands on gels indicating monomeric nature of enzyme. Activity of paternally inherited allele demonstrable in 0- to 1-hr embryos. Activity fluctuates during embryogenesis, is low during larval stages, rises precipitously just before pupation, and falls after eclosion (Detwiler and MacIntyre, 1978). DNase-1 activity isolated with lysosomal fraction of embryo homogenates (Detwiler and MacIntyre, 1980, Insect Biochem. 10: 255-63). Flies homozygous for hypomorphic allele are small with reduced viability; maturation of ovaries delayed for several days after eclosion; recombination normal (Grell, 1976). Homozygotes for the hypomorphic allele DNase1lmn accumulate low-molecular-weight, low-thermal-stability DNA, especially in the ovaries; Feulgen-positive vesicles visible in maturing oocytes near chorionic appendages (Stone, Dower, Hauseman, Cseko and Sederoff, 1983, Can. J. Genet. Cytol. 25: 129-38).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90E1-90E1   Limits computationally determined from genome sequence between P{EP}cpoEP3679 and P{EP}Dlc90FEP3634
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-61.8
Left of (cM)	sr
Right of (cM)	Ubx
Notes	Mapping based on 83 bx-sr recombinants.
Gene Model & Products
Please see the GBrowse view of Dmel\DNaseII for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) DNaseII-RA FBtr0083538  NM_142415   1228   366
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein DNaseII-PA   FBpp0082962   41.3   366   6.51     NP_650672   AAF55486
Additional Polypeptide Data & Comments
Reported size (kDa)	32 (kD) (Gaszner and Udvardy, 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Deoxyribonuclease II (IPR004947)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141153   AA942128   AE014297 AAF55486   AI114173   AI261021   AI402235   AI516922   AY075328 AAL68195   BI228415   BI231323   BI232630   BI364577   BI371166   BI373533   CK657064   CK658979   CK660274   CK660886   CK661217   CO178314   CO273494   CO297198   EC081460   EC198038   EC201858   EC230520
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VED8 Q7JYM9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval fat body   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	DNaseII protein was determined to be lysosomal on the basis of its acid pH optimum and the presence of mannose-6-phosphate residues in the sugar side chains. (Gaszner and Udvardy, 1991)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body    1334.7 Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head    527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body    778.9 Adult Salivary Gland    11159 Adult Heart    542.425 Adult VirginFemale Spermatheca    1354.8 Adult InseminatedFemale Spermatheca    927.1 Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass    531.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body  (1334.7) Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head  527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body  (778.9) Adult Salivary Gland  (11159) Adult Heart  (542.425) Adult VirginFemale Spermatheca  (1354.8) Adult InseminatedFemale Spermatheca  (927.1) Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass  531.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body  (1334.7) Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head    527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body    778.9 Adult Salivary Gland  (11159) Adult Heart    542.425 Adult VirginFemale Spermatheca  (1354.8) Adult InseminatedFemale Spermatheca    927.1 Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass    531.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body    1334.7 Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head    527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body    778.9 Adult Salivary Gland    11159 Adult Heart    542.425 Adult VirginFemale Spermatheca    1354.8 Adult InseminatedFemale Spermatheca    927.1 Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass    531.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body    1334.7 Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head    527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body    778.9 Adult Salivary Gland    11159 Adult Heart    542.425 Adult VirginFemale Spermatheca    1354.8 Adult InseminatedFemale Spermatheca    927.1 Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass    531.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body  (1334.7) Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head  527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body  778.9 Adult Salivary Gland  (11159) Adult Heart  542.425 Adult VirginFemale Spermatheca  (1354.8) Adult InseminatedFemale Spermatheca  (927.1) Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass  531.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body  1334.7 Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head    527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body    778.9 Adult Salivary Gland  (11159) Adult Heart    542.425 Adult VirginFemale Spermatheca  1354.8 Adult InseminatedFemale Spermatheca    927.1 Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass    531.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    67.5 Larval Midgut    82 Larval Hindgut    106.9 Larval Malpighian Tubules    45.4 Larval Fat Body    1334.7 Larval Salivary Gland    28 Larval Trachea    16.825 Larval Carcass    9.1 Adult Head    527 Adult Eye    175.025 Adult Brain    147.4 Adult Thoracic-Abdominal Ganglion    225.8 Adult Crop    93.8 Adult Midgut    48.3 Adult Hindgut    210.6 Adult Malpighian Tubules    85.8 Adult Fat Body    778.9 Adult Salivary Gland    11159 Adult Heart    542.425 Adult VirginFemale Spermatheca    1354.8 Adult InseminatedFemale Spermatheca    927.1 Adult Ovary    1.3 Adult Testis    5.5 Adult Male Accessory Gland    8.6 Adult Carcass    531.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    527   NA  Eye    175.025   NA  Brain    147.4   67.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    225.8   NA  Crop    93.8   82  Midgut    48.3   106.9  Hindgut    210.6   45.4  Malpighian Tubules    85.8   1334.7  Fat Body    778.9   28  Salivary Gland    11159   NA  Heart    542.425   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    1354.8   NA  InseminatedFemale Spermatheca    927.1   NA  Ovary    1.3   NA  Testis    5.5   NA  Male Accessory Gland    8.6   9.1  Carcass    531.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    26 central nervous system, pupae P8    7 head, virgin 1-day female    44 head, virgin 4-day female    59 head, virgin 20-day female    111 head, mated 1-day female    36 head, mated 4-day female    76 head, mated 20-day female    94 head, mated 1-day male    44 head, mated 4-day male    54 head, mated 20-day male    114 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    141 digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering    162 fat body, white prepupae    33 fat body, pupae P8    105 carcass, larvae L3 wandering    8 carcass, 1-day adult    53 carcass, 4-day adult    51 carcass, 20-day adult    84 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3  26 central nervous system, pupae P8    7 head, virgin 1-day female  (44) head, virgin 4-day female  (59) head, virgin 20-day female  (111) head, mated 1-day female  (36) head, mated 4-day female  (76) head, mated 20-day female  (94) head, mated 1-day male  (44) head, mated 4-day male  (54) head, mated 20-day male  (114) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (141) digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering  (162) fat body, white prepupae  (33) fat body, pupae P8  (105) carcass, larvae L3 wandering    8 carcass, 1-day adult  (53) carcass, 4-day adult  (51) carcass, 20-day adult  (84) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    26 central nervous system, pupae P8    7 head, virgin 1-day female    44 head, virgin 4-day female    59 head, virgin 20-day female  (111) head, mated 1-day female    36 head, mated 4-day female    76 head, mated 20-day female    94 head, mated 1-day male    44 head, mated 4-day male    54 head, mated 20-day male  (114) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (141) digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering  (162) fat body, white prepupae    33 fat body, pupae P8  105 carcass, larvae L3 wandering    8 carcass, 1-day adult    53 carcass, 4-day adult    51 carcass, 20-day adult    84 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    26 central nervous system, pupae P8    7 head, virgin 1-day female    44 head, virgin 4-day female    59 head, virgin 20-day female    111 head, mated 1-day female    36 head, mated 4-day female    76 head, mated 20-day female    94 head, mated 1-day male    44 head, mated 4-day male    54 head, mated 20-day male    114 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    141 digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering    162 fat body, white prepupae    33 fat body, pupae P8    105 carcass, larvae L3 wandering    8 carcass, 1-day adult    53 carcass, 4-day adult    51 carcass, 20-day adult    84 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    26 central nervous system, pupae P8    7 head, virgin 1-day female    44 head, virgin 4-day female    59 head, virgin 20-day female    111 head, mated 1-day female    36 head, mated 4-day female    76 head, mated 20-day female    94 head, mated 1-day male    44 head, mated 4-day male    54 head, mated 20-day male    114 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    141 digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering    162 fat body, white prepupae    33 fat body, pupae P8    105 carcass, larvae L3 wandering    8 carcass, 1-day adult    53 carcass, 4-day adult    51 carcass, 20-day adult    84 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3  26 central nervous system, pupae P8    7 head, virgin 1-day female  (44) head, virgin 4-day female  (59) head, virgin 20-day female  (111) head, mated 1-day female  (36) head, mated 4-day female  (76) head, mated 20-day female  (94) head, mated 1-day male  (44) head, mated 4-day male  (54) head, mated 20-day male  (114) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (141) digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering  (162) fat body, white prepupae  (33) fat body, pupae P8  (105) carcass, larvae L3 wandering    8 carcass, 1-day adult  (53) carcass, 4-day adult  (51) carcass, 20-day adult  (84) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    26 central nervous system, pupae P8    7 head, virgin 1-day female    44 head, virgin 4-day female    59 head, virgin 20-day female  111 head, mated 1-day female    36 head, mated 4-day female    76 head, mated 20-day female    94 head, mated 1-day male    44 head, mated 4-day male    54 head, mated 20-day male  114 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  141 digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering  (162) fat body, white prepupae    33 fat body, pupae P8  105 carcass, larvae L3 wandering    8 carcass, 1-day adult    53 carcass, 4-day adult    51 carcass, 20-day adult    84 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    26 central nervous system, pupae P8    7 head, virgin 1-day female    44 head, virgin 4-day female    59 head, virgin 20-day female    111 head, mated 1-day female    36 head, mated 4-day female    76 head, mated 20-day female    94 head, mated 1-day male    44 head, mated 4-day male    54 head, mated 20-day male    114 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    141 digestive system, 1-day adult    19 digestive system, 4-day adult    12 digestive system, 20-day adult    13 fat body, larvae L3 wandering    162 fat body, white prepupae    33 fat body, pupae P8    105 carcass, larvae L3 wandering    8 carcass, 1-day adult    53 carcass, 4-day adult    51 carcass, 20-day adult    84 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr    79 embryo 06-08hr    106 embryo 08-10hr    65 embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr    31 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    54 larva L2    63 larva L3 12hr old    89 larva L3 puffstage 1-2    97 larva L3 puffstage 3-6    60 larva L3 puffstage 7-9    58 white prepupae new    81 white prepupae 12hr    51 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    81 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr  (79) embryo 06-08hr  (106) embryo 08-10hr  (65) embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr  (31) embryo 18-20hr  (53) embryo 20-22hr  (50) embryo 22-24hr  (47) larva L1  (54) larva L2  (63) larva L3 12hr old  (89) larva L3 puffstage 1-2  (97) larva L3 puffstage 3-6  (60) larva L3 puffstage 7-9  (58) white prepupae new  (81) white prepupae 12hr  (51) white prepupae 24hr  (41) pupae 2d postWPP  (44) pupae 3d postWPP  (81) pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr    79 embryo 06-08hr  106 embryo 08-10hr    65 embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr    31 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    54 larva L2    63 larva L3 12hr old    89 larva L3 puffstage 1-2    97 larva L3 puffstage 3-6    60 larva L3 puffstage 7-9    58 white prepupae new    81 white prepupae 12hr    51 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    81 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr    79 embryo 06-08hr    106 embryo 08-10hr    65 embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr    31 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    54 larva L2    63 larva L3 12hr old    89 larva L3 puffstage 1-2    97 larva L3 puffstage 3-6    60 larva L3 puffstage 7-9    58 white prepupae new    81 white prepupae 12hr    51 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    81 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr    79 embryo 06-08hr    106 embryo 08-10hr    65 embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr    31 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    54 larva L2    63 larva L3 12hr old    89 larva L3 puffstage 1-2    97 larva L3 puffstage 3-6    60 larva L3 puffstage 7-9    58 white prepupae new    81 white prepupae 12hr    51 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    81 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr  (79) embryo 06-08hr  (106) embryo 08-10hr  (65) embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr  31 embryo 18-20hr  (53) embryo 20-22hr  (50) embryo 22-24hr  (47) larva L1  (54) larva L2  (63) larva L3 12hr old  (89) larva L3 puffstage 1-2  (97) larva L3 puffstage 3-6  (60) larva L3 puffstage 7-9  (58) white prepupae new  (81) white prepupae 12hr  (51) white prepupae 24hr  (41) pupae 2d postWPP  (44) pupae 3d postWPP  (81) pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr    79 embryo 06-08hr  106 embryo 08-10hr    65 embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr    31 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    54 larva L2    63 larva L3 12hr old    89 larva L3 puffstage 1-2    97 larva L3 puffstage 3-6    60 larva L3 puffstage 7-9    58 white prepupae new    81 white prepupae 12hr    51 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    81 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    19 embryo 04-06hr    79 embryo 06-08hr    106 embryo 08-10hr    65 embryo 10-12hr    23 embryo 12-14hr    9 embryo 14-16hr    17 embryo 16-18hr    31 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    54 larva L2    63 larva L3 12hr old    89 larva L3 puffstage 1-2    97 larva L3 puffstage 3-6    60 larva L3 puffstage 7-9    58 white prepupae new    81 white prepupae 12hr    51 white prepupae 24hr    41 pupae 2d postWPP    44 pupae 3d postWPP    81 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    18 adult male 30day    15 adult female 01day    18 adult female 05day    18 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    93 leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3  (93) leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    93 leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    93 leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    93 leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3  (93) leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    93 leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    8 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    93 leg disc CME L1    5 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    66 Ethanol 10% 3 hrs, larvae L3    49 Caffeine 1.5 mg/ml 4 hrs, larvae L3    55 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3  (67) Cadmium 50 mM 12 hrs, larvae L3  (45) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3  (37) Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3  (31) Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3  (66) Ethanol 10% 3 hrs, larvae L3  (49) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (55) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3  (63) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    66 Ethanol 10% 3 hrs, larvae L3    49 Caffeine 1.5 mg/ml 4 hrs, larvae L3    55 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    66 Ethanol 10% 3 hrs, larvae L3    49 Caffeine 1.5 mg/ml 4 hrs, larvae L3    55 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    66 Ethanol 10% 3 hrs, larvae L3    49 Caffeine 1.5 mg/ml 4 hrs, larvae L3    55 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3  (67) Cadmium 50 mM 12 hrs, larvae L3  (45) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3  (37) Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3  31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3  (66) Ethanol 10% 3 hrs, larvae L3  (49) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (55) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3  (63) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    66 Ethanol 10% 3 hrs, larvae L3    49 Caffeine 1.5 mg/ml 4 hrs, larvae L3    55 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    66 Ethanol 10% 3 hrs, larvae L3    49 Caffeine 1.5 mg/ml 4 hrs, larvae L3    55 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    63 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH10876 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000477 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7780-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for DNaseII Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable DNaseIIlo Sterility Allele semi-fertile DNaseIIlo Other Phenotypes Allele cell death defective DNaseIIlo cell death defective | conditional DNaseIIlo cell death defective | germline clone | oogenesis stage S14 DNaseIIlo cell death defective | oogenesis stage S14 DNaseIIlo cell death defective | oogenesis stage S14 (with Df(3R)sr16) DNaseIIlo electrophoretic variant DNaseIIF DNaseIII DNaseIIS increased cell death | embryonic stage DNaseIIlo Phenotype manifest in Allele egg chamber | conditional DNaseIIlo egg chamber | germline clone | oogenesis stage S14 DNaseIIlo egg chamber | oogenesis stage S14 DNaseIIlo egg chamber | oogenesis stage S14 (with Df(3R)sr16) DNaseIIlo nucleus | germline clone | oogenesis stage S14 DNaseIIlo nucleus | oogenesis stage S14 DNaseIIlo nurse cell | conditional DNaseIIlo nurse cell | germline clone | oogenesis stage S14 DNaseIIlo nurse cell | oogenesis stage S14 DNaseIIlo nurse cell | oogenesis stage S14 (with Df(3R)sr16) DNaseIIlo ovary DNaseIIlo
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of DNaseII Class Mutagen Stocks Known lesion DNaseIIlo hypomorphic allele - genetic evidence ethyl methanesulfonate 3 Yes DNaseIIB571 1 -- DNaseIIF natural population 1 -- DNaseIII natural population 1 -- DNaseIIlmh hypomorphic allele - genetic evidence 0 -- DNaseIIn324 loss of function allele 0 -- DNaseIIS natural population 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of DNaseII Class Mutagen Stocks Known lesion DNaseIIKK102934 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DNaseIIGD6196 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DNaseIINIG.7780R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DNaseIIScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;3)cpo3.20 (Schmidt et al., 2008)
Disrupted in	Df(3R)cpo3.42 (Schmidt et al., 2008) Df(3R)P14 (Evans et al., 2002, Mukae et al., 2002, Detwiler and MacIntyre, 1978)
Not disrupted in	T(2;3)apXa (Evans et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6196} NA P{KK102934} NA P{NIG.7780R} NA P{UAS-DNaseII.wt} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{5HPw+}DNaseIIB571 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
nurse cell apoptotic process inferred from mutant phenotype (Bass et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
deoxyribonuclease II activity inferred from sequence or structural similarity with mouse Dnase2 (FlyBase, 1992-) non-traceable author statement (Vernooy et al., 2000) traceable author statement (Evans and Aguilera, 2003)
Biological Process
CV term Evidence References
DNA catabolic process traceable author statement (Evans and Aguilera, 2003) DNA metabolic process inferred from electronic annotation with InterPro:IPR004947 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
DNaseII - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - CG5045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - GstO3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) DNaseII - awd anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) DNaseII - regucalcin anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) DNaseII - sqh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions DNaseII allele Gene References DNaseIIlo Drep-1 (Mukae et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71231 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000477 DroID - A comprehensive database of gene and protein interactions. • FBgn0000477 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48228
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SBFJ2 Dipteran inclusive ortholog search EOG6XPQQR Insect inclusive ortholog search EOG6MPGKX Arthropod inclusive ortholog search EOG6N8PMJ Metazoa inclusive ortholog search EOG6CRZSV
Orthologs in Drosophila Species (EOG6SBFJ2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\DNaseII     Drosophila simulans   Dsim\GD19194 Y   Drosophila sechellia   Dsec\GM15271 Y   Drosophila erecta   Dere\GG22593 Y   Drosophila yakuba   Dyak\GE25505 Y   Drosophila ananassae   Dana\GF16750 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20583 Y   Drosophila persimilis   Dper\GL12583 Y   Drosophila willistoni   Dwil\GK11236 Y   Drosophila virilis   Dvir\GJ23268 Y   Drosophila mojavensis   Dmoj\GI23709 Y   Drosophila grimshawi   Dgri\GH15034 Y
Orthologs in non-Drosophila Dipterans (EOG6XPQQR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012418   Anopheles gambiae Malaria mosquito  Agam\AGAP003295   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015966
Orthologs in non-Dipteran Insects (EOG6MPGKX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\DNaseII   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004014   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20292   Atta cephalotes Leafcutter ant  Acep\ACEP23808   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23057   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17645   Linepithema humile Argentine ant  Lhum\LH13729   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18554   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003079   Bombyx mori Silkmoth  Bmor\BGIBMGA008338   Pediculus humanus Human body louse  Phum\PHUM105720
Orthologs in non-Insect Arthropods (EOG6N8PMJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\SsRbeta   Ixodes scapularis Deer tick  Isca\ISCW009895   Ixodes scapularis Deer tick  Isca\ISCW007322   Ixodes scapularis Deer tick  Isca\ISCW016235
Orthologs in non-Arthropod Metazoa (EOG6CRZSV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K04H4.6   Caenorhabditis elegans Nematode  Cele\nuc-1   Caenorhabditis elegans Nematode  Cele\crn-7   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000005gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000231gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027703gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005915gn   Danio rerio Zebrafish  Drer\dnase2   Danio rerio Zebrafish  Drer\dnase2   Danio rerio Zebrafish  Drer\ENSDARG00000077918   Xenopus tropicalis Western clawed frog  Xtro\LOC733868   Xenopus tropicalis Western clawed frog  Xtro\dnase2b   Gallus gallus Domestic chicken  Ggal\DNASE2B   Mus musculus House mouse  Mmus\Dnase2b   Mus musculus House mouse  Mmus\Dnase2a   Rattus norvegicus Norway rat  Rnor\Dnase2b   Rattus norvegicus Norway rat  Rnor\Dnase2   Homo sapiens Human  Hsap\DNASE2B   Homo sapiens Human  Hsap\DNASE2
Human Orthologs (2)
Gene OMIM HGNC Hsap\DNASE2B     Hsap\DNASE2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19194 Drosophila sechellia Dsec\GM15271 Drosophila erecta Dere\GG22593 Drosophila yakuba Dyak\GE25505 Drosophila ananassae Dana\GF16750 Drosophila pseudoobscura pseudoobscura Dpse\GA20583 Drosophila persimilis Dper\GL12583 Drosophila willistoni Dwil\GK11236 Drosophila virilis Dvir\GJ23268 Drosophila mojavensis Dmoj\GI23709 Drosophila grimshawi Dgri\GH15034
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	1042 DNaseIIlo 16246 y1 w1118; PBac{5HPw+}DNaseIIB571 1034 DNase2n1 in1 kniri-1 pp cu1 DNaseIIlo es/TM3, Sb1
Kyoto	101629 DNaseIII 101754 ss1 Su(ss)3 gl1 DNaseIIF 106178 DNase2n1 in1 kniri-1 pp cu1 DNaseIIlo es/TM3, Sb1
VDRC	v100014 P{KK102934}VIE-260B
Genomic Clones ( 2 )
	BACR01C15 BACR35E22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10876
Other clones	DPiM_GH10876
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH27526 LD26176 LP05083 LP16349 LP18712 LP19834 LP20466 LP23049 RE20774 RE25955 RE28729 RE49732 RE58006 RE60849
Other clones	11093 82557 CK01.83A.D1 CK01.83D.D4 CK01269 EK056403 EK111147 EK216349
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000477 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48228
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: DNaseII CG7780 (Evans et al., 2002)
Additional comments	two unnamed hypomorphic alleles discovered by J. Stone seven unnamed null alleles discovered by Detwiler
Other Comments
	Hyperploidy for 30F-35BC and 67C-70C as well as 88C-91B caused greater than 50% increase in acid deoxyribonuclease activity (MacIntyre, 1974).   The structural gene for DNase 1, one of an estimated 7 or more DNase species (Boyd, 1969). Active on native DNA at acid pH (optimum = 4.8) and in the presence of EDTA. Heterozygotes for electrophoretic alleles show two bands on gels indicating monomeric nature of enzyme. Activity of paternally inherited allele demonstrable in 0- to 1-hr embryos. Activity fluctuates during embryogenesis, is low during larval stages, rises precipitously just before pupation, and falls after eclosion (Detwiler and MacIntyre, 1978). DNase-1 activity isolated with lysosomal fraction of embryo homogenates (Detwiler and MacIntyre, 1980). Flies homozygous for hypomorphic allele are small with reduced viability; maturation of ovaries delayed for several days after eclosion; recombination normal (Grell, 1976). Homozygotes for the hypomorphic allele DNaseIIlmh accumulate low-molecular-weight, low-thermal-stability DNA, especially in the ovaries; Feulgen-positive vesicles visible in maturing oocytes near chorionic appendages (Stone, Dower, Hauseman, Cseko and Sederoff, 1983).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142415 RefSeq (Proteins) • NP_650672 DDBJ / EMBL / GenBank • AAF55486 AAL68195 AI114173 AI402235 AY075328 Entrez Gene - A searchable database of RefSeq genes. • 48228 UniProtKB/TrEMBL • Q7JYM9 Q9VED8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Deoxyribonuclease II (IPR004947) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10876
Linkouts
	BioGRID - A database of protein and genetic interactions • 71231 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000477 DroID - A comprehensive database of gene and protein interactions. • FBgn0000477 DRSC - Results from RNAi screens. • FBgn0000477 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000477 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7780-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000477 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48228 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48228 modMine - Data generated by the modENCODE project. • FBgn0000477
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG7780 (Vierstraete et al., 2003, Stathopoulos et al., 2002, Evans et al., 2002, Vernooy et al., 2000, Keleman et al., 2009.8.5) dDNase II (Mukae et al., 2002, Evans et al., 2002) DNase (Evans and Aguilera, 2003) DNase-1 (Mukae et al., 2002) DNase 1 (Evans et al., 2002) DNase1 (Gaszner and Udvardy, 1991, ) DNaseII (Brun et al., 2006, McCall et al., 2008, Bass et al., 2009, Kupsco et al., 2006, Japanese National Institute of Genetics, 2012.5.21, Liu et al., 2012)
Name Synonym	acid DNase (Burnell et al., 1991) Deoxyribonuclease 1   Deoxyribonuclease II
Secondary FlyBase IDs
	FBgn0038563
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 1 )
	Liu et al., 2012, PLoS ONE 7(8): e42725 Drosophila EYA Regulates the Immune Response against DNA through an Evolutionarily Conserved Threonine Phosphatase Motif. [FBrf0219297] Show all research papers ...
Recent reviews (0)
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