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Gene Dmel\Pka-C3

General Information
Symbol	Dmel\Pka-C3	Species	D. melanogaster
Name	cAMP-dependent protein kinase 3	Annotation symbol	CG6117
Feature type	protein_coding_gene	FlyBase ID	FBgn0000489
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	PKA, DC2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	72B1-72B2	Sequence location	3L:15,918,904..15,947,897 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cAMP-dependent protein kinase 3 is referred to in FlyBase by the symbol Dmel\Pka-C3 (CG6117, FBgn0000489). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; cAMP-dependent protein kinase activity. There is experimental evidence that it is involved in the biological process: protein phosphorylation; imaginal disc-derived wing morphogenesis. 12 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult hindgut, larval Malpighian tubules, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult brain, larval hindgut, adult Malpighian tubules, adult heart, inseminated spermatheca, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635928_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Pka-C3. Gene sequence location is 3L:15918904..15947897.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72B1-72B2   Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
Experimentally Determined Cytological Location
Cytogenetic map Notes References 72A-72A   (determined by in situ hybridisation)   (Melendez et al., 1992) 72A-72A   (determined by in situ hybridisation)   (Kalderon and Rubin, 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pka-C3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pka-C3-RA FBtr0075529  NM_079373   2882   500 Pka-C3-RB FBtr0075528  NM_168638   2003   583
Additional Transcript Data & Comments
Reported size (kB)	3.0, 2.4 (northern blot) (Kalderon and Rubin, 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pka-C3-PA   FBpp0075284   56.7   500   4.57     NP_524097   AAF49568 Pka-C3-PB   FBpp0075283   65.4   583   4.79     NP_730083   AAN11771
Additional Polypeptide Data & Comments
Reported size (kDa)	502 (aa) (Kalderon and Rubin, 1988) 67 (kD) (Melendez et al., 1995)
Comments	Pka-C3 protein expressed in vitro has significant kinase activity that is increased slightly upon addition of cAMP. The activity was similar in a derivative protein lacking amino acids 59-120. Addition of purified Pka-R1 protein inhibits the kinase activity and this can be completely reversed by addition of cAMP. (Melendez et al., 1995)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140932   AA141121   AA141124   AA141127   AA141143   AA141196   AA141199   AA141201   AA141234   AA141323   AA141354   AA141371   AA141408   AA141422   AA141464   AA141478   AA141489   AA141497   AA141560   AA141562   AA141607   AA141609   AA141611   AA141655   AA141676   AA141689   AA141707   AA141711   AA141735   AA141736   AA141743   AA141801   AA141834   AA141881   AA142178   AA440163   AE014296 AAF49568   AE014296 AAN11771   AI124308   AI135746   AI296338   AI387761   AI531290   AI546631   AY118681 AAM50541   BF486022   BF490035   BF494138   BF496685   BF505175   BG635159   BG640306   BI142244   BI165760   BI170191   BI352942   BI564851   BI565487   BI571886   BI574131   BI575214   BI576026   BI577030   BI582454   BI583280   BI583851   BI583993   BI586861   BI588375   BI588406   BI588459   BI588663   BI588766   BI588884   BI589090   BI589239   BI589243   BI590672   BI590731   BI592794   BI593032   BI604445   BI605511   BI606547   BI607294   BI607877   BI607977   BI608784   BI608982   BI610522   BI610661   BI611018   BI611097   BI611159   BI611230   BI611710   BI612977   BI613020   BI613394   BI613754   BI615370   BI615509   BI616145   BI616581   BI616610   BI616906   BI617028   BI617090   BI617439   BI617684   BI618824   BI619653   BI620053   BI620538   BI620781   BI621147   BI621284   BI622500   BI622740   BI623088   BI623093   BI623319   BI623627   BI624745   BI625317   BI625766   BI625785   BI625802   BI626350   BI626426   BI626450   BI626871   BI627441   BI627518   BI628367   BI628419   BI628426   BI628436   BI628544   BI629001   BI629190   BI629211   BI629381   BI630149   BI630924   BI631188   BI631763   BI631785   BI631828   BI631848   BI631900   BI631995   BI634197   BI634339   BI634950   BI635165   BI636622   BI641728   BT029277   CA806411   CL705781   CO153056   CO153494   CO177555   CO179042   CO179169   CO179305   CO187196   CO187484   CO187678   CO187710   CO187913   CO189129   CO190350   CO190469   CO190773   CO190982   CO195863   CO261955   CO262568   CO263244   CO263592   CO264634   CO266208   CO266621   CO267454   CO267553   CO268027   CO268650   CO269696   CO271850   CO271971   CO274206   CO274786   CO275125   CO275338   CO275570   CO275968   CO276551   CO278383   CO278479   CO279082   CO280443   CO281966   CO282275   CO282855   CO284008   CO284265   CO284404   CO286623   CO290009   CO290180   CO290679   CO290759   CO291316   CO291587   CO291788   CO291860   CO292855   CO293512   CO293581   CO293878   CO294202   CO294380   CO294405   CO294540   CO295238   CO297010   CO297363   CO298080   CO298853   CO300381   CO300478   CO302049   CO302309   CO302349   CO302681   CO303318   CO303356   CO303980   CO304026   CO304946   CO307131   CO308453   CO309390   CO309805   CO310496   CO311647   CO311693   CO311933   CO312111   CO312182   CO315455   CO315577   CO316352   CO316667   CO317096   CO317213   CO317355   CO318300   CO319487   CO319523   CO320976   CO320977   CO321140   CO322033   CO324658   CO324776   CO325062   CO326836   CO326862   CO327048   CO327604   CO328187   CO328257   CO328314   CO328871   CO329111   CO330975   CO331792   CO332493   CO332733   CO337673   CO338920   CO339169   CO339604   CO340021   CO340197   CO340225   CO340355   CO340387   CO340748   CO340851   CO340882   CO340913   CO340947   CO341122   CO341778   CO341986   CO342406   CO343368   CO343580   CO343721   CO344264   CO344379   CO344766   CO344971   CZ483160   CZ483161   CZ489490   DN154356   EC056331   EC063798   EC068603   EC068659   EC076828   EC201576   EC203887   EC224917   EC225167   EC234138   EC240557   X16961 CAA34835
UniProtKB/Swiss-Prot	P16912
UniProtKB/TrEMBL	Q194S5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | ventral   (Melendez et al., 1995) embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi foregut anlage in statu nascendi   (Fisher et al., 2012) head mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | pair rule expression pattern   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) trunk mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi yolk nucleus   (Fisher et al., 2012) embryonic stage 5   head mesoderm   (Melendez et al., 1995) organism | pair rule expression pattern   (Melendez et al., 1995) organism | ventral   (Melendez et al., 1995) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 9 -- 10   head mesoderm   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Kalderon and Rubin, 1988) pupal stage & adult stage     (Kalderon and Rubin, 1988)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{DC2-lacZ} Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9   head mesoderm   (Melendez et al., 1995) mesoderm   (Melendez et al., 1995) larval stage   ventral thoracic disc | restricted   (Melendez et al., 1995) embryonic/larval optic stalk | surrounding   (Melendez et al., 1995) embryonic/larval optic lobe   (Melendez et al., 1995) wing disc | restricted   (Melendez et al., 1995)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult hindgut, larval Malpighian tubules, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult brain, larval hindgut, adult Malpighian tubules, adult heart, inseminated spermatheca, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules    818.7 Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass    651.7 Adult Head    278.2 Adult Eye    1164.95 Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop    774.8 Adult Midgut    59.7 Adult Hindgut    988.4 Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis    544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules  (818.7) Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass  (651.7) Adult Head    278.2 Adult Eye  (1164.95) Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop  (774.8) Adult Midgut    59.7 Adult Hindgut  (988.4) Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis  (544.2) Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules    818.7 Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass    651.7 Adult Head    278.2 Adult Eye  (1164.95) Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop    774.8 Adult Midgut    59.7 Adult Hindgut    988.4 Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis    544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules    818.7 Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass    651.7 Adult Head    278.2 Adult Eye    1164.95 Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop    774.8 Adult Midgut    59.7 Adult Hindgut    988.4 Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis    544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules    818.7 Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass    651.7 Adult Head    278.2 Adult Eye    1164.95 Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop    774.8 Adult Midgut    59.7 Adult Hindgut    988.4 Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis    544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules  (818.7) Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass  651.7 Adult Head    278.2 Adult Eye  (1164.95) Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop  774.8 Adult Midgut    59.7 Adult Hindgut  (988.4) Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis  544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules    818.7 Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass    651.7 Adult Head    278.2 Adult Eye  1164.95 Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop    774.8 Adult Midgut    59.7 Adult Hindgut    988.4 Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis    544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    25.35 Larval Midgut    67 Larval Hindgut    137.1 Larval Malpighian Tubules    818.7 Larval Fat Body    56.8 Larval Salivary Gland    7.4 Larval Trachea    72.925 Larval Carcass    651.7 Adult Head    278.2 Adult Eye    1164.95 Adult Brain    276.9 Adult Thoracic-Abdominal Ganglion    40.8 Adult Crop    774.8 Adult Midgut    59.7 Adult Hindgut    988.4 Adult Malpighian Tubules    473.7 Adult Fat Body    34.8 Adult Salivary Gland    11.5 Adult Heart    378.225 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    140.3 Adult Ovary    63.2 Adult Testis    544.2 Adult Male Accessory Gland    184.5 Adult Carcass    352.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    278.2   NA  Eye    1164.95   NA  Brain    276.9   25.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    40.8   NA  Crop    774.8   67  Midgut    59.7   137.1  Hindgut    988.4   818.7  Malpighian Tubules    473.7   no informative data  Fat Body    34.8   7.4  Salivary Gland    no informative data   NA  Heart    378.225   72.925  Trachea    NA   NA  VirginFemale Spermatheca    89.2   NA  InseminatedFemale Spermatheca    140.3   NA  Ovary    63.2   NA  Testis    544.2   NA  Male Accessory Gland    184.5   651.7  Carcass    352.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    28 head, virgin 20-day female    18 head, mated 1-day female    32 head, mated 4-day female    29 head, mated 20-day female    15 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering    39 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    36 ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male    50 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female  (27) head, virgin 4-day female  (28) head, virgin 20-day female    18 head, mated 1-day female  (32) head, mated 4-day female  (29) head, mated 20-day female    15 head, mated 1-day male  (43) head, mated 4-day male  (40) head, mated 20-day male  (33) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  (27) digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering  (39) carcass, 1-day adult  (34) carcass, 4-day adult  (47) carcass, 20-day adult  (36) ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male  (50) accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    28 head, virgin 20-day female    18 head, mated 1-day female    32 head, mated 4-day female    29 head, mated 20-day female    15 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering    39 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    36 ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male    50 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    28 head, virgin 20-day female    18 head, mated 1-day female    32 head, mated 4-day female    29 head, mated 20-day female    15 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering    39 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    36 ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male    50 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    28 head, virgin 20-day female    18 head, mated 1-day female    32 head, mated 4-day female    29 head, mated 20-day female    15 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering    39 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    36 ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male    50 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female  27 head, virgin 4-day female  28 head, virgin 20-day female    18 head, mated 1-day female  32 head, mated 4-day female  29 head, mated 20-day female    15 head, mated 1-day male  (43) head, mated 4-day male  (40) head, mated 20-day male  (33) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering  27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering  (39) carcass, 1-day adult  (34) carcass, 4-day adult  (47) carcass, 20-day adult  (36) ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male  (50) accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    28 head, virgin 20-day female    18 head, mated 1-day female    32 head, mated 4-day female    29 head, mated 20-day female    15 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering    39 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    36 ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male    50 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    28 head, virgin 20-day female    18 head, mated 1-day female    32 head, mated 4-day female    29 head, mated 20-day female    15 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    33 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    16 digestive system, 4-day adult    19 digestive system, 20-day adult    18 fat body, larvae L3 wandering    0 fat body, white prepupae    9 fat body, pupae P8    12 carcass, larvae L3 wandering    39 carcass, 1-day adult    34 carcass, 4-day adult    47 carcass, 20-day adult    36 ovary, virgin 4-day female    5 ovary, mated 4-day female    5 testis, mated 4-day male    50 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    34 white prepupae new    41 white prepupae 12hr    42 white prepupae 24hr    23 pupae 2d postWPP    50 pupae 3d postWPP    29 pupae 4d postWPP    40 adult male 01day    44 adult male 05day    62 adult male 30day    73 adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr  26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9  (34) white prepupae new  (41) white prepupae 12hr  (42) white prepupae 24hr    23 pupae 2d postWPP  (50) pupae 3d postWPP  (29) pupae 4d postWPP  (40) adult male 01day  (44) adult male 05day  (62) adult male 30day  (73) adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    34 white prepupae new    41 white prepupae 12hr    42 white prepupae 24hr    23 pupae 2d postWPP    50 pupae 3d postWPP    29 pupae 4d postWPP    40 adult male 01day    44 adult male 05day    62 adult male 30day    73 adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    34 white prepupae new    41 white prepupae 12hr    42 white prepupae 24hr    23 pupae 2d postWPP    50 pupae 3d postWPP    29 pupae 4d postWPP    40 adult male 01day    44 adult male 05day    62 adult male 30day    73 adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    34 white prepupae new    41 white prepupae 12hr    42 white prepupae 24hr    23 pupae 2d postWPP    50 pupae 3d postWPP    29 pupae 4d postWPP    40 adult male 01day    44 adult male 05day    62 adult male 30day    73 adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr  26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9  (34) white prepupae new  (41) white prepupae 12hr  (42) white prepupae 24hr    23 pupae 2d postWPP  (50) pupae 3d postWPP  29 pupae 4d postWPP  (40) adult male 01day  (44) adult male 05day  (62) adult male 30day  (73) adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    34 white prepupae new    41 white prepupae 12hr    42 white prepupae 24hr    23 pupae 2d postWPP    50 pupae 3d postWPP    29 pupae 4d postWPP    40 adult male 01day    44 adult male 05day    62 adult male 30day    73 adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    4 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    6 embryo 16-18hr    26 embryo 18-20hr    25 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    9 larva L2    8 larva L3 12hr old    10 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    34 white prepupae new    41 white prepupae 12hr    42 white prepupae 24hr    23 pupae 2d postWPP    50 pupae 3d postWPP    29 pupae 4d postWPP    40 adult male 01day    44 adult male 05day    62 adult male 30day    73 adult female 01day    15 adult female 05day    12 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    71 embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2  (71) embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2  (101) tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    71 embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2  101 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    71 embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    71 embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2  (71) embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2  (101) tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    71 embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2  101 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    71 embryonic Kc167    23 embryonic S1    6 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    54 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (27) cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (28) Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult  (54) Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    54 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    54 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    54 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult  (54) Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    54 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    54 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	BDGP expression data • AT10577 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000489 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6117-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pka-C3 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Pka-C3EY03065 Sterility Allele fertile Pka-C3EY03065 Other Phenotypes Allele visible | dominant Pka-C3KG00222 Phenotype manifest in Allele wing Pka-C3KG00222
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Pka-C3 Class Mutagen Stocks Known lesion Pka-C3EY02687 P-element activity 1 -- Pka-C3EY03065 P-element activity 1 -- Pka-C3f00695 piggyBac transposase 1 -- Pka-C3f06761 piggyBac transposase 1 -- Pka-C3KG00222 P-element activity 1 -- Pka-C3MI04507 1 -- Pka-C3MI04599 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pka-C3 Class Mutagen Stocks Known lesion Pka-C3HMS01970 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pka-C3JF02723 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pka-C3GD11825 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Pka-C3NIG.6117R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Pka-C3Pka-C1.PM in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)brm11 (Melendez and Kalderon, 1995)
Not disrupted in	Df(3L)st-f13 (Melendez and Kalderon, 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11825} NA P{NIG.6117R} NA P{TRiP.HMS01970} NA P{TRiP.JF02723} NA reporter construct P{DC2-lacZ} No characterization construct P{DC0-DC2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Pka-C3MI04507 NA Mi{MIC}Pka-C3MI04599 NA P{SUPor-P}Pka-C3KG00222 NA PBac{WH}Pka-C3f00695 NA PBac{WH}Pka-C3f06761 NA insertion of mobile activating element P{EPgy2}Pka-C3EY02687 NA P{EPgy2}Pka-C3EY03065 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
cAMP-dependent protein kinase activity inferred from direct assay (Melendez et al., 1995) protein binding inferred from physical interaction with UniProtKB:Q9U969 (assigned by UniProtKB) (Bettencourt da Cruz et al., 2008)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) protein phosphorylation inferred from direct assay (Melendez et al., 1995)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cAMP-dependent protein kinase activity inferred from sequence or structural similarity (Kalderon and Rubin, 1988) inferred from sequence or structural similarity with UniProtKB:P05383 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.8.1) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from sequence or structural similarity (Kalderon and Rubin, 1988) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1990.8.1)
Cellular Component
CV term Evidence References
cAMP-dependent protein kinase complex inferred from sequence or structural similarity (Kalderon and Rubin, 1988)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pka-C3 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65045 DroID - A comprehensive database of gene and protein interactions. • FBgn0000489 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39733 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P16912
Orthologs
OrthoDB Orthologs (65) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG689569 Dipteran inclusive ortholog search EOG6894VZ Insect inclusive ortholog search EOG6THTPS Arthropod inclusive ortholog search EOG6MCVG1 Metazoa inclusive ortholog search EOG6SBSRS
Orthologs in Drosophila Species (EOG689569)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pka-C3     Drosophila simulans   Dsim\GD12529 Y   Drosophila erecta   Dere\GG13511 Y   Drosophila yakuba   Dyak\GE23130     Drosophila yakuba   Dyak\GE19804     Drosophila ananassae   Dana\GF10368 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23555 Y   Drosophila persimilis   Dper\GL24922 Y   Drosophila willistoni   Dwil\GK20594 Y   Drosophila virilis   Dvir\GJ22504     Drosophila mojavensis   Dmoj\GI11297 Y   Drosophila grimshawi   Dgri\GH17207 Y
Orthologs in non-Drosophila Dipterans (EOG6894VZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011837   Anopheles gambiae Malaria mosquito  Agam\AGAP011840
Orthologs in non-Dipteran Insects (EOG6THTPS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Pka-C1 Y Apis mellifera Western honey bee  Amel\Pka-C3 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011355 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13955 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23993 Y Atta cephalotes Leafcutter ant  Acep\ACEP16274 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17734 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21016 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12493 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23012 Y Linepithema humile Argentine ant  Lhum\LH22324 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB19604 Y Solenopsis invicta Red fire ant  Sinv\SINV21739 Y Solenopsis invicta Red fire ant  Sinv\SINV19480 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000519 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005952 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011429 Y Pediculus humanus Human body louse  Phum\PHUM318270 Y Pediculus humanus Human body louse  Phum\PHUM090820 Y Tribolium castaneum Red flour beetle  Tcas\TC014143 Y Tribolium castaneum Red flour beetle  Tcas\Pka-C1 Y
Orthologs in non-Insect Arthropods (EOG6MCVG1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Tmem198 Y Daphnia pulex Water flea  Dpux\gltA Y Ixodes scapularis Deer tick  Isca\ISCW013988 Y
Orthologs in non-Arthropod Metazoa (EOG6SBSRS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F47F2.1 Y Caenorhabditis elegans Nematode  Cele\ZK909.2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020398gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004024gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022180gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016045gn Y Danio rerio Zebrafish  Drer\prkacbb Y Danio rerio Zebrafish  Drer\prkacab Y Danio rerio Zebrafish  Drer\prkacaa Y Danio rerio Zebrafish  Drer\prkacbb Y Danio rerio Zebrafish  Drer\prkx Y Danio rerio Zebrafish  Drer\prkacba Y Xenopus tropicalis Western clawed frog  Xtro\prkaca Y Xenopus tropicalis Western clawed frog  Xtro\prkacb Y Xenopus tropicalis Western clawed frog  Xtro\prkx Y Gallus gallus Domestic chicken  Ggal\PRKX Y Gallus gallus Domestic chicken  Ggal\PRKACB Y Mus musculus House mouse  Mmus\Prkx Y Mus musculus House mouse  Mmus\Prkaca Y Mus musculus House mouse  Mmus\Prkacb Y Rattus norvegicus Norway rat  Rnor\Prkaca Y Rattus norvegicus Norway rat  Rnor\Prkx Y Rattus norvegicus Norway rat  Rnor\Prkacb Y Homo sapiens Human  Hsap\PRKX Y Homo sapiens Human  Hsap\PRKACA Y Homo sapiens Human  Hsap\PRKACG Y Homo sapiens Human  Hsap\PRKACB Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\PRKX     Hsap\PRKACA     Hsap\PRKACG     Hsap\PRKACB
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12529 Drosophila erecta Dere\GG13511 Drosophila ananassae Dana\GF10368 Drosophila pseudoobscura pseudoobscura Dpse\GA23555 Drosophila persimilis Dper\GL24922 Drosophila willistoni Dwil\GK20594 Drosophila mojavensis Dmoj\GI11297 Drosophila grimshawi Dgri\GH17207
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	27569 y1 v1; P{TRiP.JF02723}attP2 40768 y1 w*; Mi{MIC}Pka-C3MI04507 15581 y1 w67c23; P{EPgy2}Pka-C3EY02687 19832 y1 w67c23; P{EPgy2}Pka-C3EY03065 39050 y1 sc* v1; P{TRiP.HMS01970}attP2 14345 y1 w67c23; P{SUPor-P}Pka-C3KG00222 ry506 37962 y1 w*; Mi{MIC}Pka-C3MI04599/TM3, Sb1 Ser1
Harvard	- PBac{WH}Pka-C3f00695 - PBac{WH}Pka-C3f06761
Genomic Clones ( 2 )
	BACR06P13 BACR18K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 315 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT10577 IP09935
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02564 AT07350 AT20151 AT26308 AT31652 GH13608 GH18414 GM21379 LD14764 LP10204 RE05714 RE11569 RH04324 RH04390 RH07193 RH10576 RH10904 RH11852 RH12090 RH13479 RH13709 RH16019 RH16209 RH17093 RH17215 RH17293 RH17409 RH18095 RH20543 RH21653 RH21844 RH22556 RH22735 RH26972 RH29568 RH29611 RH29690 RH29717 RH30058 RH30182 RH30333 RH30767 RH31611 RH31616 RH32493 RH33778 RH37622 RH38076 RH39930 RH42014 RH42077 RH42543 RH42985 RH44978 RH45176 RH46016 RH46595 RH46639 RH47060 RH47229 RH47315 RH47775 RH48091 RH49746 RH50730 RH51215 RH51705 RH51995 RH52448 RH52603 RH54383 RH54653 RH55168 RH55173 RH55446 RH55941 RH56741 RH56809 RH56819 RH56839 RH56978 RH57786 RH58019 RH58044 RH58239 RH59131 RH60268 RH60713 RH61408 RH61433 RH61478 RH61508 RH61578 RH61691 RH62378 RH63266 RH64377 RH65659 RH66252 RH66273 RH66292 RH67049 RH67365 RH67395 RH67957 RH68761 RH68859 RH69793 RH71145 RH73083 RH74330 SD02265 SD09524 SD11290 SD16292 SD16426 SD18363 SD25304
Other clones	46915 74134 78472 83077 100164 117745 158374 AI124308 CK01.10D.B10 CK01.11A.A12 CK01.19B.H10 CK00330 CK01023 CK01258 CK01331 CK01336 CK01363 CK01421 CK01448 CK01456 CK01462 CK01603 CK01617 CK01634 CK01718 CK01792 CK01833 CK01958 CK02010 CK02026 CK02083 CK02089 CK02102 CK02134 CK02139 CK02216 CK02225 CK02311 CK02315 CK02322 CK02323 CK02429 CK02526 CK02564 CK02584 CK02648 EC41454 EC056331 EK027108 EK030002 EK031312 EK032025 EK034826 EK043120 EK047843 EK048304 EK049563 EK050409 EK053809 EK058252 EK058646 EK059016 EK063402 EK072843 EK073259 EK074745 EK075111 EK077604 EK082259 EK085812 EK087859 EK089024 EK089958 EK092228 EK095603 EK104936 EK105342 EK113540 EK115509 EK116527 EK117157 EK117938 EK119258 EK121312 EK129929 EK130147 EK133510 EK139758 EK145429 EK147049 EK150160 EK150812 EK154064 EK159214 EK160129 EK161453 EK165022 EK165624 EK165964 EK171327 EK174002 EK178057 EK178259 EK182949 EK183856 EK183952 EK184711 EK187045 EK194453 EK194822 EK195502 EK197709 EK198161 EK198534 EK201106 EK203155 EK203715 EK205033 EK206320 EK206804 EK206844 EK207149 EK209011 EK215732 EK216813 EK217506 EK219351 EK221844 EK222762 EK225650 EK225919 EK227244 EK227895 EK228028 EK240954 EK241147 EK243327 EK243447 EK246762 EK253707 EK258226 EK261529 EK261906 EK264714 EK265613 EK267119 EK267342 EK267760 EK271504 EK278350 EK278462 EK289455 EK289458 EK290364 EK291554 EK292041 EK296753 EK301716 EK303642 EK304364 EN01164 EN02064 EN15045 EP00315 EP01012 EP02341 EP04728 EP04754 EP05547 EP07649 EP08720 EP08834 EP08943 EP09905 EP10203 EP10234 EP10464 EP10540 EP11254 EP11446 EP11516 EP11550 EP11622 EP11914 EP13133 EP13602 EP14842 EP16650 EP17315 EP17909 EP18944 EP19157 EP19847 EP21045 ESG013a.E21.1_H09
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000489 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39733
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutational analysis reveals that Pka-C3 is not an essential gene and is unlikely to be functionally redundant with Pka-C1, which has multiple unique functions during development. (Melendez et al., 1995) Pka-C3 is first expressed in mesodermal anlagen before cellularisation. Expression depends on dl, but not twi or sna gene activities. (Melendez et al., 1992) Isolated from a genomic library using a Pka-C1 probe. (Kalderon and Rubin, 1988) Pka-C3 may encode a protein kinase. (Kalderon and Rubin, 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079373 NM_168638 RefSeq (Proteins) • NP_524097 NP_730083 DDBJ / EMBL / GenBank • AAF49568 AAM50541 AAN11771 AY118681 BF496685 CAA34835 CL705781 CZ483160 CZ483161 CZ489490 X16961 Entrez Gene - A searchable database of RefSeq genes. • 39733 UniProtKB/Swiss-Prot • P16912 UniProtKB/TrEMBL • Q194S5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT10577
Linkouts
	BioGRID - A database of protein and genetic interactions • 65045 DroID - A comprehensive database of gene and protein interactions. • FBgn0000489 DRSC - Results from RNAi screens. • FBgn0000489 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000489 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6117-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000489 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39733 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39733 modMine - Data generated by the modENCODE project. • FBgn0000489 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P16912
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	5-23 (Kalderon and Rubin, 1988, ) CG6117 (Metaxakis et al., 2005, Morrison et al., 2000, Carrera et al., 2008, Perkins et al., 2009, Ni et al., 2010.12.1) DC2 (Majercak et al., 1997, Melendez et al., 1995, Melendez and Kalderon, 1995, Melendez et al., 1992, Siegfried et al., 1990, Kalderon and Rubin, 1988, Diskar et al., 2010) Dpck   Pk72A   Pk?5   PKA (Zhang et al., 2005, Ogden et al., 2004, Shaw and Franken, 2003, Aza-Blanc and Kornberg, 1999, Welte, 2004, Bangi et al., 2007, Jia et al., 2005) PKA-C-3 (Dworkin and Gibson., 2006) PKA C3 (Morrison et al., 2000) Pka-C3 (Wijnen et al., 2006, Dworkin and Gibson, 2006, Izutsu et al., 2012, Akdemir et al., 2007, Frise et al., 2010, Bakal et al., 2008, Carrera et al., 2008, Wang et al., 2004, Gao et al., 2008, Cooper and Kennison, 2011, Jumbo-Lucioni et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Ruben et al., 2012) PKA-C3 (Bettencourt da Cruz et al., 2008)
Name Synonym	cAMP-activated protein kinase A (Gronke et al., 2005) cAMP-dependent protein kinase   cAMP-dependent protein kinase 3 (Dworkin and Gibson, 2006) Protein-kinase-like-72A   Swiss Cheese (Bettencourt da Cruz et al., 2008)
Secondary FlyBase IDs
	FBgn0004631
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 7 ) Review  ( 5 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 3 )
	Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Ruben et al., 2012, J. Biol. Rhythms 27(5): 353--364 A mechanism for circadian control of pacemaker neuron excitability. [FBrf0219602] Cooper and Kennison, 2011, PLoS ONE 6(8): e23509 Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D. [FBrf0214748] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...