General Information
Symbol
Dmel\dpp
Species
D. melanogaster
Name
decapentaplegic
Annotation Symbol
CG9885
Feature Type
FlyBase ID
FBgn0000490
Gene Model Status
Stock Availability
Gene Snapshot
Decapentaplegic is a ligand of the transforming growth factor-β signaling pathway that signals through Smad transcription factors. Dpp acts as a morphogen that contributes to growth regulation, patterning and stem cell fate. [Date last reviewed: 2016-06-30]
Also Known As
BMP, shv, TGF-β, TGF-beta, l(2)22Fa
Genomic Location
Cytogenetic map
Sequence location
2L:2,428,372..2,459,823 [+]
Recombination map
2-6
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the TGF-beta family. (P07713)
Summaries
UniProt Contributed Function Data
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.
(UniProt, P07713)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
dpp: decapentaplegic (W.M. Gelbart)
dpp is a complex locus affecting numerous developmental events. Mutations fall into three major genetic and phenotypic groupings: called shortvein (shv), Haplo-insufficiency (Hin) and imaginal disk-specific (disk). Each group maps to a different region of the dpp gene. Hin-region mutations have two distinguishing features: they are defective in normal dorsal-ventral patterning of the embryo, and they generally fail to complement mutations of the shv and disk types. shv-region mutations all show recessive defects in longitudinal wing vein formation. disk-region mutations exhibit pattern deletions in the adult epidermal derivatives of the imaginal disks. The phenotypes of most shv/disk heterozygotes suggest partial or full complementation of the shv and disk lesions. Within each of the three major groupings, several phenotypic classes of alleles have been identified. Complementation between certain combinations of dpp alleles is transvection sensitive (Gelbart, 1982, Proc. Nat. Acad. Sci. USA 79: 2636-40). The genetic properties of the several classes of dpp mutations are outlined below. For a given class, the prototypical recessive phenotypes are inferred from examinations of trans heterozygotes for two different alleles of that class. This procedure obviates possible complications due to the frequent association of dpp mutations with gross chromosomal rearrangements. Particular allelic combinations may deviate from the prototypical descriptions. Hin-region emb: Embryonic lethal mutation. Homozygous viable, but recessive lethal in combination with hin-r alleles, and, in the latter background, exhibits the same weakly ventralized phenotype as hin-r homozygotes. Completely complements all shv- and disk-region mutations. The sole emb allele is associated with a small deletion in Hin-region. Hin: Haplo-insufficient mutations. Hin/+ heterozygotes exhibit dominant embryonic lethality with the same weakly ventralized phenotype as hin-r homozygotes. Dominant lethality is rescued by duplication of dppHin+. Homozygotes are defective in gastrulation and die as embryos with completely ventralized cuticle. In general, Hin alleles do not complement any other dpp mutations. However, Hin alleles associated with small deletions or point mutations exhibit transvection effects in heterozygotes with small deletions or insertions in the shv and disk-regions. Hin mutations are considered the null alleles of the dpp gene. Hin alleles are associated with breakpoints, small deletions or point mutations in the Hin-region. Hin-Df: Haplo-insufficient mutations which are behave identically to breakoint Hin mutations, except that Hin-Df lesions are gross deletions removing the entire dpp gene and adjacent vital loci. hin-r: Recessive mutations behaving as milder versions of the Hin lesions. In homozygotes, hin-r mutations exhibit embryonic lethality with weak ventralization effects (identical to emb/hin-r or Hin/+ heterozygotes). All hin-r mutations engender temperature-sensitive mutant phenotypes when heterozygous with shv- and disk-region mutations. Phenotypes elicited in heterozygotes with small deletions, or insertions in the shv and disk regions are transvection sensitive. All hin-r mutations are cytologically normal and show no alterations in their restriction maps. Some have been associated with point mutations in the Hin-region. shv-region shv-lc: Recessive larval-lethal shortvein alleles which complement all disk-region mutations. Exhibit mutant phenotypes in heterozygotes with all shv, Hin, and hin-r mutations. Mutations generally associated with rearrangement breakpoints. shv-lnc: Recessive larval-lethal shortvein alleles which do not complement disk-region mutations. Also exhibit mutant phenotypes in heterozygotes with all shv, Hin, and hin-r mutations. Mutations generally associated with rearrangement breakpoints. shv-p: Recessive shortvein alleles surviving at least to pharate adult. Only two alleles are known; one (s11) is adult viable; exhibits strong venation defects, and variable head capsule defects, including loss of palps, and misarranged vibrissae. Allelic to all shv, Hin, and hin-r mutations. Complement all disk-region mutations. Both alleles are associated with rearrangement breakpoints. shv-w: Recessive viable and fertile shortvein alleles exhibiting only venation defects. Associated with small deletions of the shv-region. Venation phenotype allelic to all shv, Hin, and hin-r mutations. shv-w/Hin, and shv-w/hin-r mutant phenotypes are transvection sensitive. Only two alleles are known; both are associated with small deletions in the shv-region. Tg: A dominant gain-of-function allele in which the tegula on the wing appears duplicated. Tg/+ wings are held out and down. Distinct in phenotype from heldout (d-ho) homozygotes. Tg completely complements all dpp mutations. The dominant effects of Tg can be reverted by superimposing shv, Hin, or hin-r mutations on the Tg chromosome. The one Tg allele is associated with a rearrangement breakpoint in or near the shv-region. disk-region disk-blk: Recessive viable and fertile allele in which the only mutant phenotype is loss of 80-90% of ommatidia in eye; hence this allele was designated blink by Sparrow (unpublished). Exhibits mutant eye phenotypes in heterozygotes with disk-III, disk-V, Hin, and hin-r mutations. Can exhibit transvection effects. The one disk-blk allele is associated with a small deletion within the disk-region. disk-ho: Recessive viable and fertile alleles in which the only mutant phenotypes are heldout wings and loss of the Sc25 on the dorsal base of the wing. Heldout phenotype displayed in heteroyzgotes with all disk-region mutations except d-blk, and with Hin and hin-r mutations. Can exhibit transvection effects. In addition to the one mutant allele listed here, which is associated with a small deletion within the disk-region, several cytologically normal disk-ho alleles have been associated with mobilization of hobo mobile elements residing in the disk-region. disk-II: Recessive viable alleles. Homozygotes exhibit reductions in wing blade, haltere and male genitalia. Elicit mutant phenotypes in heterozygotes with all disk-region mutations except d-blk, and with Hin and hin-r mutations. Mildest class of disk-region alleles associated with rearrangement breakpoints. disk-III: Recessive viable alleles. Homozygotes exhibit multiple pattern abnormalities in epidermis of head, thorax, and terminalia. Structures absent or reduced include labial palps, arista, eye, wing blade, capitellum of haltere, tarsal claws, male terminalia, and female analia. Elicit mutant phenotypes in heterozygotes with all disk-region mutations, and with Hin and hin-r mutations. Intermediate class of disk-region alleles associated with rearrangement breakpoints. disk-V: Recessive early pupal lethal alleles. Homozygous larvae have greatly reduced imaginal disks. Elicit mutant phenotypes in heterozygotes with all disk-region mutations and with Hin and hin-r mutations. Most severe class of disk-region alleles associated with rearrangement breakpoints. t: Recessive larval-lethal alleles. Allelic to all disk, Hin, and hin-r mutations. The only two known alleles of this class behave identically to disk-V lesions, except for the earlier recessive lethal period. Tentatively classified as part of the disk-region. These two mutations are associated with breakpoints which map between the two tRNAtyr genes residing at the Hin-disk-V boundary. Hence the t designation is used to describe these alleles.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\dpp or the JBrowse view of Dmel\dpp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.42
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077771
3723
588
FBtr0077772
3177
588
FBtr0077773
4230
588
FBtr0077775
3216
588
Additional Transcript Data and Comments
Reported size (kB)
4.5 (unknown)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077451
65.9
588
10.41
FBpp0077452
65.9
588
10.41
FBpp0077453
65.9
588
10.41
FBpp0077455
65.9
588
10.41
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

588 aa isoforms: dpp-PA, dpp-PB, dpp-PC, dpp-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern. Component of a complex composed of dpp, sog and tsg.
(UniProt, P07713)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dpp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (95 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:dally; FB:FBgn0263930
inferred from physical interaction with UniProtKB:P54631
(assigned by UniProt )
inferred from physical interaction with UniProtKB:P07713
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948
(assigned by InterPro )
non-traceable author statement
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
Biological Process (81 terms)
Terms Based on Experimental Evidence (49 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from expression pattern
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:P27091
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (46 terms)
CV Term
Evidence
References
non-traceable author statement
traceable author statement
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218210
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
non-traceable author statement
traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
traceable author statement
traceable author statement
traceable author statement
non-traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
traceable author statement
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
colocalizes_with cytoneme
inferred from direct assay
inferred from direct assay
colocalizes_with endosome
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
Expression Data
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
wing vein | precursor

Comment: reference states 6-9 hr APF

wing vein | precursor

Comment: reference states >=18-20 hr APF

RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
In addtion to expression anterior to and close to the A/P boundary of third instar wing discs, dpp expression is observed in a proximal region of the posterior compartment. Similar expression is observed in the haltere disc. Expression in both cases begins in the mid-third-instar larval stage. From the fate map, this region gives rise to proximal adult wing structures including the alula and axillary cord.
dpp transcripts are strongly expressed in the spiracular chambers, spiracular branches, and dorsal trunk branches of the tracheal system. Expression is seen in the spiracular chamber form embryonic stage 13 and appears in the spriacular branch and dorsal trunk branches at stage 14. At stage 17, dpp is absent from the spriacular chamber but persists throughout the length of the dorsal trunk branches.
dpp transcript is expressed at lower levels in the haltere disc than in the wing disc.
dpp expression is observed to form a gradient in the dorsal blastoderm. At later stages, dpp expression is observed in the esophageal visceral mesoderm.
dpp is observed to be expressed in somatic cells of the testis.
dpp is observed to be expressed in somatic cells of the germarium.
Transcript is detected in 12 cell widths at the A/P boundary in third instar wing discs. However, expression is excluded from the D/V boundary that will form the wing margin.
dpp is expressed in the dorsal region of the embryo corresponding to the presumptive dorsal ectoderm.
The dpp transcript is expressed along the anterior-posterior boundary of the wing disc.
In wing and leg imaginal discs, sog transcript is expressed in stripes parallel to the dpp stripe along the compartment border. dpp expression along the A/P border disappears in early prepupae. In late prepupae (6-9 hr AP) dpp is expressed in stripes corresponding to vein primordia. dpp expression in vein primordia reappears in 18-20 hr pupae, and expression continues to be restricted to vein primordia in 25-30 hr pupae. Double labeling experiments with sog and dpp transcripts show that sog and dpp are expressed in a strictly complementary pattern in most of the pupal wing, with the exception of the L5 vein, where there is a one-cell-wide gap between sog and dpp expressing cells.
dpp transcripts are expressed along the anterior-posterior boundary in the central region of the wing disc, and approximately along the anterior-posterior boundary in the leg disc. In the eye-antennal disc, expression is detected in the medial regions and along the morphogenetic forrow. Transcripts are detecting in the larval brain in two lateral and two medial spots. Higher levels of staining are detected in the male genital discs than in the female, and the transcripts are also distributed approximately along the anterior-posterior boundary. dpp expression was also detected in late embryonic stages with high levels of transcripts detected in the cephalic and thoracic segments at stage 11 and 13, and in the embryonic brain at stage 13.
dpp is expressed in two stripes in the visceral mesoderm, the posterior of which coincides with Ubx expression in parasegment 7. dpp transcripts are undetectable in parasegment 7 in Ubx mutant embryos. The domain of dpp expression in the visceral mesoderm is expanded posteriorly in abd-A mutants.
dpp transcripts are missing in the visceral mesoderm but not in the ectoderm of putative dpps4 homozygous embryos.
The dpp transcript expression pattern was analyzed in imaginal discs from early third instar larvae through prepupae. Expression is detected in the ventral wing pouch region of the wing disc in early third instar larvae, and in a stripe along the center of the wing disc, as well as low levels along the posterior edge, in late third instar discs. Leg disc expression is first detected as a stripe limited to the medial region of the disc, and then expands into a discontinuous stripe across the entire disc. In the eye-imaginal disc, expression is detected in the periphery of the eye region and laterally in the antennal region. This expression is maintained through late third instar, and additonal expression is detected medially in the antennal region and along the morphogenetic forrow in the eye region. During imaginal disc eversion continued expression of dpp transcripts in detected. In addition to the expression pattern observed during larval devlopment, expression is detected in an anterior stripe in the wing disc, and the dpp transcript expression pattern is resolved into a band along the proximo-distal axis of the appendages.
By the end of germband shortening, dpp RNA is detected at six distinct sites along the gut tube. The sites of expression in the foregut are within the anlage of the pharynx and the esophagus. The midgut sites are within the anlage of the gastric caeca, and the 2nd and 3rd midgut constrictions, the latter being very weak. dpp RNA is also detected in the ectoderm of the hindgut. Embryos with mutations in the shv region of dpp lack midgut expression and have reduced foregut expression, though the early embryo expression pattern is normal. abd-A mutations cause expansion of the domain of dpp expression in the visceral mesoderm to include the entire posterior midgut.
The dpp transcript is expressed in the central region of the wing disc, along the anterior-posterior boundary.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
dpp protein was detected in the extracellular lumenal space between the peripodial and columnar epithelium in leg, wing and eye discs of third instar larvae. In addition dpp protein is expressed intracellularly in the known dpp expression domains including an asymetrically distributed anterior/posterior gradient originating at the A/P boundary in wing discs, with a shallower gradient and wider gradient in the anterior compartment. dpp protein was also detected in the morphogenetic furrow of the eye disc.
dpp protein is present in the visceral mesoderm at and anterior to the second midgut constriction from embryonic stage 14. By stage 16, dpp protein surrounds the adjacent endoderm cells.
dpp and Ubx proteins are expressed in overlapping domains in the visceral mesoderm in parasegment 7. The dpp domain extends further anteriorly by half a parasegment. dpp protein is nearly absent in the visceral mesoderm in Ubx6.28 embryos. In a background where Ubx is ectopically expressed all over the embryo, dpp protein is ectopically expressed in the visceral mesoderm from the anterior end of the midgut to PS 7. In embryos lacking abd-A, the Ubx and dpp expression domains extend to the posterior end of the visceral mesoderm. Mutations that remove both Ubx and abd-A cause a novel dpp expression pattern. Embryos that lack genomic copies of Ubx and abd-A but have ectopic Ubx expression from a hs-Ubx construct have ectopic dpp expression throughout the entire visceral mesoderm.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
colocalizes_with cytoneme
inferred from direct assay
inferred from direct assay
colocalizes_with endosome
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{419exd}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{-980/dpp-lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{BS1.1}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{BS3.0}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{BS3.1}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp0.8}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp45}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp265lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp303lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp419forward}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp674lacZ}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp.3KK-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dppshv-lacZ.RD2}
Stage
Tissue/Position (including subcellular localization)
Reference
wing vein

Comment: in longitudinal veins

Reporter: P{dppΔDR}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp-GAL4.PS}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp-lacZ.B}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp-lacZ.BE}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{dpp-lacZ.Exel.2}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GAL4-dpp.blk1}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GAL4-dpp.H}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}dpp10638
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{PZ}P1552
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dpp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 207 )
For All Classical and Insertion Alleles Show
 
Allele of dpp
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      Yes
      Other relevant insertions
      insertion of mobile activating element
      Name
      Expression Data
      miscellaneous insertions
      Name
      Expression Data
      Transgenic Constructs ( 105 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of dpp
      Allele of dpp
      Mutagen
      Associated Transgenic Construct
      Stocks
      Transgenic constructs containing regulatory region of dpp
      vital-reporter construct
      heat-shock construct
      Name
      Expression Data
      reporter construct
      Name
      Expression Data
      Deletions and Duplications ( 58 )
      Disrupted in
      Partially duplicated in
      Summary of Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      Sterility
      Allele
      Other Phenotypes
      Allele
      Phenotype manifest in
      Allele
      actin filament & tracheal tip cell & embryo, with Scer\GAL4btl.PS
      adult thorax & adult epidermis
      cytoneme & dorsal mesothoracic disc | somatic clone (with dpphr4)
      cytoneme & dorsal mesothoracic disc | somatic clone (with dpphr56)
      denticle belt & thorax
      embryonic/larval fat body & parasegment 4, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 5, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 6, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 6, with Scer\GAL4zen.Kr.PF
      embryonic/larval fat body & parasegment 7, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 7, with Scer\GAL4zen.Kr.PF
      embryonic/larval fat body & parasegment 8, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 8, with Scer\GAL4zen.Kr.PF
      embryonic/larval fat body & parasegment 9, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 10, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 11, with Scer\GAL4twi.PGa
      embryonic/larval fat body & parasegment 12, with Scer\GAL4twi.PGa
      eye disc & photoreceptor cell, with Scer\GAL4Act5C.PP
      eye disc & subretinal glial cell, with Scer\GAL4Act5C.PP
      glial cell & eye | ectopic, with Scer\GAL4Act5C.PP
      glial cell & eye | ectopic, with Scer\GAL4GMR.PF
      macrochaeta & scutum
      parasegment 13 & mesoderm | ventral, with Scer\GAL4twi.PGa
      scutellum & macrochaeta, with Scer\GAL4dpp.blk1
      Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (33)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      11 of 15
      Yes
      Yes
      10 of 15
      No
      Yes
       
      4 of 15
      No
      Yes
      3 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      1 of 15
      No
      Yes
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
       
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (33)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      11 of 15
      Yes
      Yes
      10 of 15
      No
      Yes
      4 of 15
      No
      Yes
      3 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes
      2 of 15
      No
      Yes