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Gene Dmel\dsh

General Information
Symbol	Dmel\dsh	Species	D. melanogaster
Name	dishevelled	Annotation symbol	CG18361
Feature type	protein_coding_gene	FlyBase ID	FBgn0000499
Gene Model Status	Current	Stock availability	24 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-34.5
Cytogenetic map	10B4-10B5	Sequence location	X:11,249,914..11,252,757 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dishevelled is referred to in FlyBase by the symbol Dmel\dsh (CG18361, FBgn0000499). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatidic acid binding. There is experimental evidence for 27 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; biological regulation; regulation of developmental process; post-embryonic organ morphogenesis; sensory organ development; cellular component movement; establishment of planar polarity; cell projection assembly; multicellular organism reproduction. 147 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; external compound sense organ; larval abdominal segment; portion of tissue; non-connected developing system; appendage segment; thoracic segment; peripheral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: DEP domain; DIX domain; Dishevelled Dsh; Dishevelled family; Dishevelled protein domain; Dishevelled-related protein; PDZ domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628788_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dsh. Gene sequence location is X:11249914..11252757.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	dsh: dishevelled Most alleles lethal, but dsh1, although poorly viable as homozygous females or hemizygous males, appears to be fully viable when heterozygous to a deficiency for the region, suggesting that the reduced viability is unrelated to dsh1. dsh1 flies have deranged thoracic hairs, divergent and blistered wings, and ellipsoid eyes. Leg bristles, hairs, and bracts display high frequencies of abnormal polarity; extra joints or joint primordia found frequently in the first and second tarsal joints of the first and second pairs of legs; of 270 ectopic joints, 268 displayed inverted polarity [Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57 (fig.)]. Males and females fertile, males weakly so. Homozygotes and hemizygotes for the lethal alleles die as second- to early-third-instar larvae when derived from heterozygous mothers; when derived from homozygous germ-line clones, on the other hand, embryos with segment-polarity defects result; only ventral cuticle is present, covered with a lawn of setae; lack dorsal cuticle, posterior spiracles and filzkorper material. At six to seven hours maxillary and labial segments appear to be missing and parasegmental boundaries do not form; cell death apparent in vicinity of tracheal pits, which subsequently fuse; segmental boundaries fail to form; organization of central nervous system seems normal. Loss of cells of posterior segment compartments leads to discontinued production of en+ product. Viability of dsh1/dsh3, for example, when derived from homozygous dsh3 oogenic clones, is normal, indicating that dsh1 is wild type for the early function.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms Wnt receptor signaling pathway, planar cell polarity pathway cell cortex
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10B4-10B5   Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10B3-10B10   (determined by in situ hybridisation)   (Peter et al., 2002) 10B3-10B10   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 10B5-10B11   (determined by in situ hybridisation)   (Marsh, 198?)
Experimentally Determined Recombination Data
Location	1-33.5 (Fahmy and Fahmy, 1959) 1-34.5
Left of (cM)
Right of (cM)	rtv (Zhimulev et al., 1981)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dsh for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dsh-RA FBtr0073454  NM_078563   2844   623
Additional Transcript Data & Comments
Reported size (kB)	2.9, 2.6 (northern blot) (Klingensmith et al., 1994) 2.7 (northern blot) (Theisen et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dsh-PA   FBpp0073310   68.9   623   6.29     NP_511118   AAF48033
Additional Polypeptide Data & Comments
Reported size (kDa)	623 (aa); 70 (kD predicted) (Theisen et al., 1994) 623 (aa); 70 (kD observed) (Klingensmith et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DEP domain (IPR000591) DIX domain (IPR001158) PDZ domain (IPR001478) Dishevelled protein domain (IPR003351) Dishevelled family (IPR008339) Winged helix-turn-helix DNA-binding domain (IPR011991) Dishevelled-related protein (IPR015506) Dishevelled Dsh (IPR026542)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201981   AA246334   AA390429   AA390636   AA538752   AA696284   AA803092   AA817239   AA950845   AA950848   AA978778   AA979235   AE014298 AAF48033   AI297617   AJ426859   AY863528 AAW57900   AY863529 AAW57901   AY863530 AAW57902   AY863531 AAW57903   AY863532 AAW57904   AY863533 AAW57905   AY863534 AAW57906   AY863535 AAW57907   AY863536 AAW57908   AY863537 AAW57909   AY863538 AAW57910   AY863539 AAW57911   AY863540 AAW57912   AY863541 AAW57913   AY863542 AAW57914   AY863543 AAW57915   AY863544 AAW57916   AY863545 AAW57917   AY863546 AAW57918   AY863547 AAW57919   AY863548 AAW57920   AY863549 AAW57921   AY863550 AAW57922   BE977029   BG638170   BG640201   BI173411   BI173793   BI216034   BI216109   BI216277   BI238257   BI239116   BI240716   BI482577   BI485747   BI486252   BI564581   BT023781   CK132880   CO177297   CO177306   CO271225   CO286477   CO299019   CO301954   CO312845   CO336635   EC065058   EC069657   EC082529   EC194955   EC195277   L26974 AAA16535   U02491 AAA20216
UniProtKB/Swiss-Prot	P51140
UniProtKB/TrEMBL	Q5G232 Q8IR91
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Theisen et al., 1994) larval stage   imaginal disc   (Theisen et al., 1994) adult stage & oogenesis   egg chamber   (Theisen et al., 1994) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Klingensmith et al., 1994) embryonic stage -- adult stage     (Klingensmith et al., 1994) embryonic stage 11   organism | ubiquitous   (Klingensmith et al., 1994)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   imaginal disc | dorsal/ventral compartment boundary   • apical plasma membrane (Muñoz-Descalzo et al., 2010) imaginal disc | dorsal/ventral compartment boundary   • basolateral plasma membrane (Muñoz-Descalzo et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Strutt et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    263.625 Larval Midgut    29.7 Larval Hindgut    54 Larval Malpighian Tubules    53.1 Larval Fat Body    28.1 Larval Salivary Gland    73 Larval Trachea    53.025 Larval Carcass    62.45 Adult Head    78.5 Adult Eye    109.9 Adult Brain    215.2 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    81.8 Adult Midgut    29.6 Adult Hindgut    50.9 Adult Malpighian Tubules    64.1 Adult Fat Body    29.5 Adult Salivary Gland    66.1 Adult Heart    45.875 Adult VirginFemale Spermatheca    69.2 Adult InseminatedFemale Spermatheca    97.6 Adult Ovary    165.5 Adult Testis    30.5 Adult Male Accessory Gland    60.1 Adult Carcass    51.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    78.5   NA  Eye    109.9   NA  Brain    215.2   263.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    119.8   NA  Crop    81.8   29.7  Midgut    29.6   54  Hindgut    50.9   53.1  Malpighian Tubules    64.1   28.1  Fat Body    29.5   73  Salivary Gland    66.1   NA  Heart    45.875   53.025  Trachea    NA   NA  VirginFemale Spermatheca    69.2   NA  InseminatedFemale Spermatheca    97.6   NA  Ovary    165.5   NA  Testis    30.5   NA  Male Accessory Gland    60.1   62.45  Carcass    51.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    33 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    71 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (33) central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female  (31) ovary, mated 4-day female  (30) testis, mated 4-day male  (71) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    33 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    71 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    33 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    71 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    33 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    71 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (33) central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female  31 ovary, mated 4-day female  30 testis, mated 4-day male  (71) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    33 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    71 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    33 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    12 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    31 ovary, mated 4-day female    30 testis, mated 4-day male    71 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    80 embryo 04-06hr    37 embryo 06-08hr    43 embryo 08-10hr    41 embryo 10-12hr    42 embryo 12-14hr    26 embryo 14-16hr    37 embryo 16-18hr    26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day    29 adult male 30day    32 adult female 01day    21 adult female 05day    29 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (70) embryo 02-04hr  (80) embryo 04-06hr  (37) embryo 06-08hr  (43) embryo 08-10hr  (41) embryo 10-12hr  (42) embryo 12-14hr  26 embryo 14-16hr  (37) embryo 16-18hr  26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr  (30) pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day  (29) adult male 30day  (32) adult female 01day    21 adult female 05day  (29) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    80 embryo 04-06hr    37 embryo 06-08hr    43 embryo 08-10hr    41 embryo 10-12hr    42 embryo 12-14hr    26 embryo 14-16hr    37 embryo 16-18hr    26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day    29 adult male 30day    32 adult female 01day    21 adult female 05day    29 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    80 embryo 04-06hr    37 embryo 06-08hr    43 embryo 08-10hr    41 embryo 10-12hr    42 embryo 12-14hr    26 embryo 14-16hr    37 embryo 16-18hr    26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day    29 adult male 30day    32 adult female 01day    21 adult female 05day    29 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    80 embryo 04-06hr    37 embryo 06-08hr    43 embryo 08-10hr    41 embryo 10-12hr    42 embryo 12-14hr    26 embryo 14-16hr    37 embryo 16-18hr    26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day    29 adult male 30day    32 adult female 01day    21 adult female 05day    29 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (70) embryo 02-04hr  (80) embryo 04-06hr  (37) embryo 06-08hr  (43) embryo 08-10hr  (41) embryo 10-12hr  (42) embryo 12-14hr  26 embryo 14-16hr  (37) embryo 16-18hr  26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr  30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day  29 adult male 30day  32 adult female 01day    21 adult female 05day  29 adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    80 embryo 04-06hr    37 embryo 06-08hr    43 embryo 08-10hr    41 embryo 10-12hr    42 embryo 12-14hr    26 embryo 14-16hr    37 embryo 16-18hr    26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day    29 adult male 30day    32 adult female 01day    21 adult female 05day    29 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    80 embryo 04-06hr    37 embryo 06-08hr    43 embryo 08-10hr    41 embryo 10-12hr    42 embryo 12-14hr    26 embryo 14-16hr    37 embryo 16-18hr    26 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    18 larva L1    11 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    17 white prepupae 12hr    22 white prepupae 24hr    30 pupae 2d postWPP    21 pupae 3d postWPP    14 pupae 4d postWPP    19 adult male 01day    20 adult male 05day    29 adult male 30day    32 adult female 01day    21 adult female 05day    29 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167  (29) embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9  (28) wing disc ML-DmD16-c3  (27) wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (27) eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167  29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9  28 wing disc ML-DmD16-c3  27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    16 embryonic Kc167    29 embryonic S1    20 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    13 wing disc ML-DmD8    18 wing disc ML-DmD9    28 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    23 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    27 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    23 ovary fGS/OSS    22 ovary OSC    23 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (32) Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000499 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18361-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dsh3 lethal, with Scer\GAL4da.G32 dsh8-1.Scer\UAS.T:Hsap\MYC lethal | embryonic stage | recessive dsh3 dsh6 lethal | heat sensitive, with Scer\GAL4ptc-559.1 dshScer\UAS.cAa lethal | larval stage dsh3 lethal | larval stage | recessive dsh3 lethal | larval stage | recessive | rescuable maternal effect dsh3 dsh4 dsh6 dsh7 dsh8 lethal | pharate adult stage dshG0267 lethal | pharate adult stage | recessive dsh6 lethal | pupal stage, with Scer\GAL4da.G32 dsh8-9.Scer\UAS.T:Hsap\MYC dsh8-12.Scer\UAS.T:Hsap\MYC dsh8-79.Scer\UAS.T:Hsap\MYC dsh8-80.Scer\UAS.T:Hsap\MYC dsh16-1.Scer\UAS.T:Hsap\MYC lethal | pupal stage, with Scer\GAL4dpp.blk1 dshQ27.Scer\UAS lethal | recessive dsh3 dsh4 dshG0267 partially lethal - majority die, with Scer\GAL469B dsh8-1.Scer\UAS.T:Hsap\MYC partially lethal - majority die, with Scer\GAL4elav.PU dshQ27.Scer\UAS dshQ108.Scer\UAS dshΔQ.Scer\UAS partially lethal - majority die, with Scer\GAL4hs.2sev dshQ27.Scer\UAS dshQ108.Scer\UAS dshΔQ.Scer\UAS partially lethal - majority live dsh1 viable dsh1 dshA3 viable, with Scer\GAL4da.G32 dsh8-16.Scer\UAS.T:Hsap\MYC dsh8-19.Scer\UAS.T:Hsap\MYC dsh8-43.Scer\UAS.T:Hsap\MYC dsh8-64.Scer\UAS.T:Hsap\MYC dsh8-65.Scer\UAS.T:Hsap\MYC dsh16-37.Scer\UAS.T:Hsap\MYC dsh16-43.Scer\UAS.T:Hsap\MYC viable, with Scer\GAL4dpp.blk1 dshQ108.Scer\UAS dshΔQ.Scer\UAS viable (with dsh1) dsh3 viable (with dsh3) dsh1 viable | male dsh1 Sterility Allele female sterile dsh1 fertile dsh1 dshA3 male fertile dsh1 Other Phenotypes Allele cell death defective | embryonic stage dsh3 dsh4 cell polarity defective dsh1 dshhs.PA cell polarity defective, with Scer\GAL4hs.2sev dshScer\UAS.cNa neuroanatomy defective dsh4 neuroanatomy defective, with Scer\GAL4GMR.PF dshScer\UAS.cAa dshΔDEP+.Scer\UAS neuroanatomy defective | dominant dsh1 dsh6 neuroanatomy defective | third instar larval stage dsh1 planar polarity defective dsh1 dsh3 dshA3 dshA21 dshhs.sev.B dshsev.PU dshunspecified planar polarity defective, with dsh3 dshK417R.T:Avic\GFP-EGFP dshY473F.T:Avic\GFP-EGFP planar polarity defective, with dsh3, dshY473F.T:Avic\GFP-EGFP dshY474F.T:Avic\GFP-EGFP planar polarity defective, with dsh3, dshY474F.T:Avic\GFP-EGFP dshY473F.T:Avic\GFP-EGFP planar polarity defective, with dshK417R.T:Avic\GFP-EGFP dsh3 planar polarity defective, with dshY473F.T:Avic\GFP-EGFP dsh3 planar polarity defective, with dshY473F.T:Avic\GFP-EGFP, dshY474F.T:Avic\GFP-EGFP dsh3 planar polarity defective, with Scer\GAL469B dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-9.Scer\UAS.T:Hsap\MYC dsh8-12.Scer\UAS.T:Hsap\MYC dsh8-16.Scer\UAS.T:Hsap\MYC dsh8-19.Scer\UAS.T:Hsap\MYC dsh8-43.Scer\UAS.T:Hsap\MYC dsh8-64.Scer\UAS.T:Hsap\MYC dsh8-68.Scer\UAS.T:Hsap\MYC dsh8-79.Scer\UAS.T:Hsap\MYC dsh8-80.Scer\UAS.T:Hsap\MYC dsh16-1.Scer\UAS.T:Hsap\MYC dsh16-37.Scer\UAS.T:Hsap\MYC dsh16-43.Scer\UAS.T:Hsap\MYC dshScer\UAS.T:Hsap\MYC planar polarity defective, with Scer\GAL4arm.PS dshΔDIX.Scer\UAS planar polarity defective, with Scer\GAL4hs.2sev dshScer\UAS.cNa planar polarity defective, with Scer\GAL4hs.PB dshΔbPDZ.Scer\UAS dshΔDEP+.Scer\UAS planar polarity defective, with Scer\GAL4ptc-559.1 dshΔbPDZ.Scer\UAS dshΔDEP+.Scer\UAS planar polarity defective (with dsh1) dsh3 planar polarity defective (with dsh3) dsh1 dshA3 planar polarity defective (with dshA3) dsh3 planar polarity defective | cell autonomous | recessive | somatic clone dsh3 planar polarity defective | cell autonomous | somatic clone dsh1 planar polarity defective | cell non-autonomous | recessive | somatic clone dsh3 planar polarity defective | dominant dshΔC.hs.sev planar polarity defective | dominant | heat sensitive dshhs.PA dshhs.sev.B planar polarity defective | germline clone dsh3 planar polarity defective | germline clone, with Scer\GAL4arm.PS, dsh3 dshΔDIX.Scer\UAS planar polarity defective | germline clone, with Scer\GAL4arm.PS, dshΔDIX.Scer\UAS dsh3 planar polarity defective | heat sensitive dshDEP+.hs planar polarity defective | recessive dsh1 planar polarity defective | recessive | somatic clone dsh3 planar polarity defective | somatic clone dsh3 visible dsh1 dsh3 visible, with dsh4 dshw visible, with dshw dsh4 visible, with Scer\GAL469B dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-68.Scer\UAS.T:Hsap\MYC dshScer\UAS.T:Hsap\MYC visible, with Scer\GAL4dpp.blk1 dshQ108.Scer\UAS visible, with Scer\GAL4GMR.PF dsh1.Scer\UAS.T:Hsap\MYC dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-9.Scer\UAS.T:Hsap\MYC dsh8-12.Scer\UAS.T:Hsap\MYC dsh8-68.Scer\UAS.T:Hsap\MYC dsh8-79.Scer\UAS.T:Hsap\MYC dsh8-80.Scer\UAS.T:Hsap\MYC dshScer\UAS.cAa dshScer\UAS.T:Hsap\MYC dshΔbPDZ.Scer\UAS visible, with Scer\GAL4hs.2sev dshQ27.Scer\UAS dshQ108.Scer\UAS dshΔQ.Scer\UAS visible, with Scer\GAL4hs.PB dshΔDIX.Scer\UAS visible, with Scer\GAL4ptc-559.1 dshScer\UAS.cAa visible, with Scer\GAL4rho-rhl dshScer\UAS.cAa visible, with Scer\GAL4Ubx.PdC dshScer\UAS.cAa visible | heat sensitive dshhs.PA visible | recessive dsh1 visible | recessive | somatic clone dsh3 dsh75 visible | somatic clone dsh75 wild-type dsh1.hs.sev dsh+t7.5 dsh+t7EX dshcAa dshfl.cKa dshhs.PA dshhs.sev.B dshT:Avic\GFP-EGFP dshΔbPDZ dshΔC.hs.sev dshΔDIX.hs.sev dshΔPDZ.hs.sev Phenotype manifest in Allele abdominal 1 ventral denticle belt dsh3 dsh477 abdominal 1 ventral denticle belt | germline clone dsh477 abdominal 2 ventral denticle belt dsh3 dsh477 abdominal 2 ventral denticle belt | germline clone dsh477 abdominal 3 ventral denticle belt dsh3 dsh477 abdominal 3 ventral denticle belt | germline clone dsh477 abdominal 4 ventral denticle belt dsh3 dsh477 dshdsRNA.cRa abdominal 4 ventral denticle belt | germline clone dsh477 abdominal 5 ventral denticle belt dsh3 dsh477 dshdsRNA.cRa abdominal 5 ventral denticle belt | germline clone dsh477 abdominal 6 ventral denticle belt dsh3 dsh477 abdominal 6 ventral denticle belt | germline clone dsh477 abdominal 7 ventral denticle belt dsh3 dsh477 abdominal 7 ventral denticle belt | germline clone dsh477 abdominal 8 ventral denticle belt dsh3 adult, with dsh4 dshw adult, with dshw dsh4 adult cuticle dsh3 adult head dsh3 adult thorax dshA21 dshA3 adult thorax & microchaeta dsh1 amnioserosa dsh3 antenna dsh6 antenna, with dsh4 dshw antenna, with dshw dsh4 axillary pouch | somatic clone dsh75 axon & dorsal cluster neuron dsh1 dsh6 border follicle cell dsh1 border follicle cell, with Scer\GAL4slbo.2.6 dshdsRNA.Scer\UAS cephalopharyngeal skeleton dsh3 dshDIX dshbPDZ chaeta dsh1 chaeta (with dsh1) dsh3 chaeta (with dsh3) dsh1 class IV dendritic arborizing neuron dsh1 denticle dsh3 denticle, with Scer\GAL4arm.PS dshΔDIX.Scer\UAS denticle | germline clone dsh3 denticle | germline clone, with Scer\GAL4arm.PS, dsh3 dshΔDIX.Scer\UAS denticle | germline clone, with Scer\GAL4arm.PS, dshΔDIX.Scer\UAS dsh3 denticle | maternal effect, with Scer\GAL4arm.PS, dsh3 dshΔDIX.Scer\UAS denticle | maternal effect, with Scer\GAL4arm.PS, dshΔDIX.Scer\UAS dsh3 denticle belt dsh3 dsh75 dshcAa dshdsRNA.cRa denticle belt, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 dshScer\UAS.cAa dorsal margin photoreceptor | ectopic dsh3 dorsal margin photoreceptor | somatic clone dsh3 dorsal wing blade | anterior dsh1 egg chamber (with dsh1) dsh4 egg chamber (with dsh4) dsh1 embryo | germline clone | segment polarity expression pattern dsh3 embryonic/first instar larval cuticle dsh3 dshcAa embryonic/first instar larval cuticle, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 dshScer\UAS.cAa embryonic/first instar larval cuticle | dorsal | germline clone dsh3 dsh4 dsh6 dsh7 dsh8 embryonic/first instar larval cuticle | germline clone dsh3 embryonic/first instar larval cuticle | germline clone | maternal effect dsh3 embryonic/larval dorsal trunk dsh1 embryonic/larval dorsal trunk, with Scer\GAL4btl.PS dshScer\UAS.cAa embryonic/larval dorsal trunk | germline clone dsh3 embryonic/larval dorsal vessel dsh75 embryonic/larval dorsal vessel | precursor dsh75 embryonic/larval tracheal system | germline clone dsh3 embryonic dorsal epidermis dsh3 embryonic dorsal epidermis | germline clone | maternal effect dsh3 embryonic epidermis dsh3 dshdsRNA.cRa embryonic epidermis, with Scer\GAL4arm.PS dshΔDIX.Scer\UAS embryonic epidermis | dorsal dsh75 embryonic head dsh3 embryonic head | germline clone dsh3 embryonic leading edge cell dsh3 embryonic leading edge cell & actin filament dsh3 embryonic leading edge cell & filopodium dsh3 embryonic leading edge cell & microtubule dsh3 embryonic leading edge cell | germline clone | maternal effect dsh3 embryonic ventral epidermis | germline clone dsh3 external sensory organ precursor cell I dsh1 eye dsh1 eye, with Scer\GAL4GMR.PF dshΔbPDZ.Scer\UAS dsh1.Scer\UAS.T:Hsap\MYC dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-12.Scer\UAS.T:Hsap\MYC dsh8-68.Scer\UAS.T:Hsap\MYC dsh8-79.Scer\UAS.T:Hsap\MYC dsh8-80.Scer\UAS.T:Hsap\MYC dsh8-9.Scer\UAS.T:Hsap\MYC dshScer\UAS.T:Hsap\MYC dshScer\UAS.cAa eye, with Scer\GAL4hs.2sev dshQ27.Scer\UAS dshΔQ.Scer\UAS dshQ108.Scer\UAS eye | somatic clone dsh3 eye disc | somatic clone dsh3 eye photoreceptor cell dsh4 eye photoreceptor cell, with Scer\GAL4GMR.PF dshΔDEP+.Scer\UAS dshScer\UAS.cAa eye photoreceptor cell, with Scer\GAL4hs.2sev dshScer\UAS.cNa eye photoreceptor cell | somatic clone dsh3 filzkorper dsh3 dshDIX dshbPDZ filzkorper | germline clone dsh3 dsh4 dsh6 dsh7 dsh8 follicle cell | somatic clone dsh477 follicle stem cell | somatic clone dsh3 dsh4 frons dsh6 fronto-orbital plate dsh6 germarium (with dsh1) dsh4 germarium (with dsh4) dsh1 interfollicle cell | supernumerary | heat sensitive, with Scer\GAL4hs.PB dshScer\UAS.cAa interommatidial bristle dsh1 interommatidial bristle, with Scer\GAL4GMR.PF dshScer\UAS.cAa joint | ectopic dsh1 lamina dsh4 lamina, with Scer\GAL4GMR.PF dshΔDEP+.Scer\UAS dshScer\UAS.cAa leg dsh3 dsh6 leg & joint dsh1 leg | somatic clone dsh3 dsh75 leg | somatic clone | ventral dsh3 macrochaeta dsh1 macrochaeta, with Scer\GAL4ptc-559.1 dshScer\UAS.cAa macrochaeta, with Scer\GAL4Ubx.PdC dshScer\UAS.cAa macrochaeta & scutellum, with Scer\GAL4ptc-559.1 dshScer\UAS.cAa macrochaeta & wing dsh3 dshhs.PA macrochaeta | ectopic dsh3 macrochaeta | somatic clone dsh75 medial triple row dsh3 mesothoracic femoral bract dsh1 mesothoracic tergum & trichome dsh1 mesothoracic tibial bract dsh1 mesothoracic ventral denticle belt dsh3 metathoracic femoral bract dsh1 metathoracic tibial bract dsh1 metathoracic ventral denticle belt dsh3 microchaeta dsh1 microchaeta & scutellum, with Scer\GAL4ptc-559.1 dshScer\UAS.cAa microchaeta & scutum, with Scer\GAL4rho-rhl dshScer\UAS.cAa microchaeta | supernumerary | heat sensitive dshhs.PA midgut constriction 2 dsh3 midgut constriction 2 | embryonic stage dsh3 morphogenetic furrow, with Scer\GAL4dpp.blk1 dshScer\UAS.cAa neuron dsh4 neuron, with Scer\GAL4GMR.PF dshΔDEP+.Scer\UAS dshScer\UAS.cAa ocellus | ectopic dsh3 ommatidium dshΔC.hs.sev dsh1 dsh3 dshhs.sev dshhs.sev.B dshsev.PU ommatidium, with Scer\GAL4GMR.PF dshScer\UAS.cAa ommatidium, with Scer\GAL4hs.2sev dshScer\UAS.cNa ommatidium | cell autonomous | somatic clone dsh3 ommatidium | cell non-autonomous | somatic clone dsh3 ommatidium | ectopic dsh3 ommatidium | heat sensitive dshhs.sev.B ommatidium | somatic clone dsh3 ommatidium | somatic clone | supernumerary dsh3 ovarian sheath (with dsh1) dsh4 ovarian sheath (with dsh4) dsh1 ovary (with dsh1) dsh4 ovary (with dsh4) dsh1 photoreceptor cell | somatic clone dsh3 photoreceptor cell R4 dshhs.sev.B pigment cell | somatic clone dsh3 pleural wing process | somatic clone dsh75 pleural wing sclerite | somatic clone dsh75 presumptive embryonic salivary gland, with Scer\GAL4fkh.PZ dshDIX.Scer\UAS dshbPDZ.Scer\UAS primordium of embryonic/larval spiracle | germline clone | posterior dsh3 dsh4 dsh6 dsh7 dsh8 pronotum dshw prothoracic femoral bract dsh1 prothoracic tibial bract dsh1 prothoracic ventral denticle belt dsh3 scutum, with dsh4 dshw scutum, with dshw dsh4 secondary pigment cell | somatic clone dsh3 sensory mother cell dshhs.PA sensory mother cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4sd-SG29.1 dshScer\UAS.cAa stomodeal invagination dsh3 tarsal segment 1 & joint dshunspecified tarsal segment 2 & joint dshunspecified tarsal segment 3 dshunspecified tarsal segment 4 dshunspecified tertiary pigment cell | somatic clone dsh3 trichome dsh1 trichome (with dsh1) dsh3 trichome (with dsh3) dsh1 triple row dshunspecified triple row | somatic clone dsh3 ventral thoracic disc dsh3 wing dsh1 dsh3 dsh6 dshA21 dshA3 dshunspecified dshw wing, with dsh4 dshw wing, with dshw dsh4 wing, with Scer\GAL469B dsh16-1.Scer\UAS.T:Hsap\MYC dsh16-37.Scer\UAS.T:Hsap\MYC dsh16-43.Scer\UAS.T:Hsap\MYC dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-12.Scer\UAS.T:Hsap\MYC dsh8-16.Scer\UAS.T:Hsap\MYC dsh8-19.Scer\UAS.T:Hsap\MYC dsh8-43.Scer\UAS.T:Hsap\MYC dsh8-64.Scer\UAS.T:Hsap\MYC dsh8-68.Scer\UAS.T:Hsap\MYC dsh8-79.Scer\UAS.T:Hsap\MYC dsh8-80.Scer\UAS.T:Hsap\MYC dsh8-9.Scer\UAS.T:Hsap\MYC dshScer\UAS.T:Hsap\MYC wing, with Scer\GAL4hs.PB dshΔDIX.Scer\UAS wing & macrochaeta dsh3 wing & triple row | somatic clone dsh3 wing | pupal stage dsh1 wing | somatic clone dsh75 wing disc, with Scer\GAL4ptc-559.1 dshScer\UAS.cNa wing hair dsh1 dshhs.PA dshunspecified wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1 dshScer\UAS.cAa wing hair | cell autonomous | somatic clone dsh1 wing hair | supernumerary dsh1 wing hinge | dorsal | somatic clone dsh75 wing margin bristle | ectopic dsh3 wing margin bristle | ectopic, with Scer\GAL469B dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-68.Scer\UAS.T:Hsap\MYC dshScer\UAS.T:Hsap\MYC wing margin bristle | ectopic, with Scer\GAL4vg.PM dshScer\UAS.cNa wing sensillum | ectopic | somatic clone dsh75 wing vein, with Scer\GAL469B dsh16-1.Scer\UAS.T:Hsap\MYC dsh8-1.Scer\UAS.T:Hsap\MYC dsh8-12.Scer\UAS.T:Hsap\MYC dshScer\UAS.T:Hsap\MYC wing vein, with Scer\GAL4dpp.blk1 dshQ108.Scer\UAS wing vein, with Scer\GAL4hs.2sev dshQ27.Scer\UAS dshΔQ.Scer\UAS dshQ108.Scer\UAS yellow club | somatic clone dsh75
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of dsh Class Mutagen Stocks Known lesion dsh3 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 4 Yes dsh6 loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl nitrosourea 2 -- dsh1 hypomorphic allele - genetic evidence methyl methanesulfonate 2 Yes dshG0267 P-element activity 2 -- dshA3 ethyl methanesulfonate 1 Yes dsh4 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 -- dsh75 loss of function allele, amorphic allele - genetic evidence 0 -- dsh7 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- dsh8 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- dsh2 p-N,N-di-(2-chloroethyl)amino-D-phenylalanine 0 -- dsh477 0 -- dsh5 ethyl nitrosourea 0 -- dshA21 ethyl nitrosourea 0 Yes dshb117 loss of function allele 0 -- dshsevE.sevP.PS 0 -- dshunspecified 0 --
Alleles Carried on Transgenic Constructs ( 131 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dsh Class Mutagen Stocks Known lesion dshScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes dsh8-1.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 1 Yes dsh8-12.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 1 Yes dsh8-16.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 1 Yes dsh8-64.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 1 Yes dsh8-65.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 1 Yes dshJF01253 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dshJF01254 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dshK417R.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes dshKK108967 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dshT:Hsap\MYC in vitro construct - coding region fusion 1 Yes dshY473F.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes dsh+t7.5 in vitro construct - genomic fragment 0 Yes dsh+t7EX in vitro construct - genomic fragment 0 Yes dsh1.hs.sev in vitro construct - amino acid replacement 0 Yes dsh1.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dsh1.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes dsh1.tAa in vitro construct - amino acid replacement 0 Yes dsh16-1.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh16-37.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh16-43.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh395-623 in vitro construct - RNAi 0 Yes dsh8-19.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh8-43.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh8-68.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh8-79.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh8-80.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsh8-9.Scer\UAS.T:Hsap\MYC ethyl nitrosourea 0 Yes dsha.395-623 in vitro construct - RNAi 0 Yes dshAct5C.PD in vitro construct - regulatory fusion 0 Yes dshAct5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dshbPDZ.hs in vitro construct - regulatory fusion 0 Yes dshbPDZ.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshbPDZ in vitro construct 0 Yes dshC-term1-2.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshC-term1-3.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshC-term2-3.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshC-term2.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshC-term5Y-F.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 -- dshcAa in vitro construct 0 Yes dshCK2.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshCK3.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshCK4.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshD1.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshD2.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshD3.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshD4.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshD5.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshD6.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshD7.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshDbr.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes dshDdhr.MtnA.T:Hsap\MYC in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dshDEP+.hs in vitro construct - regulatory fusion 0 Yes dshDEP+.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshDEP+ in vitro construct 0 Yes dshDEP6A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshDIX.hs in vitro construct - regulatory fusion 0 Yes dshDIX.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshDIX in vitro construct 0 Yes dshdsRNA.cGa in vitro construct - RNAi 0 Yes dshdsRNA.cMa in vitro construct - RNAi 0 -- dshdsRNA.cRa in vitro construct - RNAi 0 Yes dshdsRNA.cYa in vitro construct - RNAi 0 Yes dshdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes dshfl.cKa in vitro construct - genomic fragment 0 Yes dshfl.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes dshHindIII in vitro construct 0 Yes dshhs.PA in vitro construct - regulatory fusion 0 Yes dshhs.sev.B in vitro construct - regulatory fusion 0 Yes dshhs.sev in vitro construct - regulatory fusion 0 Yes dshhs.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes dshK417M.Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes dshKR.E.2x.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshKR.E.5x.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshMtnA.PR in vitro construct - regulatory fusion 0 Yes dshMtnA.PY in vitro construct - regulatory fusion 0 Yes dshMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dshNIG.18361R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dshQ108.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes dshQ108 in vitro construct 0 Yes dshQ27.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshQ27 in vitro construct 0 Yes dshS254A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS266A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS271A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS283A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS406A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS406E.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS451A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS451E.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshS469A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshScer\UAS.cAa in vitro construct - regulatory fusion 0 Yes dshScer\UAS.cNa in vitro construct - regulatory fusion 0 Yes dshScer\UAS.T:Avic\GFP in vitro construct - coding region fusion 0 Yes dshsev.PU in vitro construct - regulatory fusion 0 Yes dshST1.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshST124.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshST4.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshST45.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes dshST5.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes dshST8.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes dshT252A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT314A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT349A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT36A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT419A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT419E.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT462A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT467A.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes dshT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes dshw in vitro construct - genomic fragment 0 Yes dshY24F.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshY280F.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshY474F.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dshΔBasic.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes dshΔbPDZ.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshΔbPDZ in vitro construct 0 Yes dshΔC.hs.sev in vitro construct - deletion 0 Yes dshΔC.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - deletion 0 Yes dshΔDEP+.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshΔDEP+ in vitro construct 0 Yes dshΔDEPD-2.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes dshΔDIX.hs.sev in vitro construct - deletion 0 Yes dshΔDIX.Scer\UAS in vitro construct - regulatory fusion 0 Yes dshΔDIX in vitro construct 0 Yes dshΔEP+ in vitro construct 0 Yes dshΔPDZ.hs.sev in vitro construct - deletion 0 Yes dshΔPDZ.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes dshΔQ.Scer\UAS in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dshΔQ in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BSC287 (Christensen and Cook, 2007.5.8) Df(1)BSC288 (Christensen and Cook, 2007.5.8) Df(1)BSC658 (Christensen et al., 2008.12.28) Df(1)BSC722 (Christensen et al., 2008.12.28) Df(1)GA112 (Theisen et al., 1994, Krasnow et al., 1995) Df(1)KA7 (Zhimulev et al., 1981, Zhimulev, 1982, Zhimulev et al., 1987) Df(1)N71 (Zhimulev et al., 1981, Zhimulev, 1982, Zhimulev et al., 1987, Woods and Bryant, 1989, Caggese et al., 1994) Df(1)RA37 (Zhimulev et al., 1981, Zhimulev, 1982, Zhimulev et al., 1987, Woods and Bryant, 1989, Caggese et al., 1994) Df(1)v65b (Zhimulev et al., 1981, Zhimulev, 1982) Df(1)v-N48 (Krasnow et al., 1995)
Duplicated in	Dp(1;2)v+63i (Lefevre, 1981) Dp(1;2)v+65b (Lefevre, 1981, Geer et al., 1983, Zhimulev et al., 1987) Dp(1;2)v+75d (Geer et al., 1983) Dp(1;3)DC237 (Popodi et al., 2010-, Venken et al., 2010) Dp(1;3)DC238 (Popodi et al., 2010-, Venken et al., 2010) Dp(1;Y)dsh+y+ (Zhimulev et al., 1987) Dp(1;Y)v+y+ (Zhimulev et al., 1981, Zhimulev, 1982, Geer et al., 1983, Zhimulev et al., 1987, Woods and Bryant, 1989) Dp(1;Y)v+y+366 (Zhimulev et al., 1987) Dp(1;Y)y+v+#3 (Krasnow et al., 1995)
Not disrupted in	Df(1)59D3 (Zhimulev et al., 1987) Df(1)203C10 (Zhimulev et al., 1987) Df(1)DA622 (Woods and Bryant, 1989, Caggese et al., 1994) Df(1)HC133 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)m13 (Woods and Bryant, 1989, Caggese et al., 1994) Df(1)ras-P14 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)ras-v17 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)ras-v-P26 (Zhimulev et al., 1987) Df(1)sbr1 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr8 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr9 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr10 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v64f (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-B151 (Zhimulev et al., 1987) Df(1)v-L1 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L2 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L3 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L4 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L7 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-L11 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-L15 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M1 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M5 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M6 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M7 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-P5 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-P16 (Zhimulev et al., 1987) Df(1)v-P22 (Zhimulev et al., 1987)
Not duplicated in	Dp(1;2)v+63i (Zhimulev et al., 1981, Zhimulev, 1982, Geer et al., 1983, Zhimulev et al., 1987) Dp(1;Y)v+y+U15 (Zhimulev et al., 1987)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108967} NA P{NIG.18361R} NA P{TRiP.JF01253} NA P{TRiP.JF01254} NA P{UAS-dsh.A} NA P{UAS-dsh.bPDZ} NA P{UAS-dsh.DEP+} NA P{UAS-dsh.DIX} NA P{UAS-dsh.GFP} NA P{UAS-dsh.myc} NA P{UAS-dsh.N} NA P{UAS-dsh.Q27} NA P{UAS-dsh.Q108} NA P{UAS-dsh.RNAi} NA P{UAS-dsh.ΔbPDZ} NA P{UAS-dsh.ΔDEP+} NA P{UAS-dsh.ΔDIX} NA P{UAS-dsh.ΔQ} NA P{UAS-dsh1.myc} NA P{UAS-dsh8-1.myc} NA P{UAS-dsh8-9.myc} NA P{UAS-dsh8-12.myc} NA P{UAS-dsh8-16.myc} NA P{UAS-dsh8-19.myc} NA P{UAS-dsh8-43.myc} NA P{UAS-dsh8-64.myc} NA P{UAS-dsh8-65.myc} NA P{UAS-dsh8-68.myc} NA P{UAS-dsh8-79.myc} NA P{UAS-dsh8-80.myc} NA P{UAS-dsh16-1.myc} NA P{UAS-dsh16-37.myc} NA P{UAS-dsh16-43.myc} NA heat-shock construct P{Hs:dsh} NA P{hs-dsh.bPDZ} NA P{hs-dsh.CK2} NA P{hs-dsh.CK3} NA P{hs-dsh.CK4} NA P{hs-dsh.DEP+} NA P{hs-dsh.DIX} NA P{hs-dsh.full} NA P{hs-dsh.ST1} NA P{hs-dsh.ST4} NA P{hs-dsh.ST45} NA P{hs-dsh.ST124} NA P{hs-dsh.ΔBasic} NA P{hs-dsh.ΔDEPD-2} NA P{hs-dsh.ΔPDZ} NA P{sE-Dsh.B} NA P{sE-Dsh1.B} NA P{sE-DshΔC.B} NA P{sE-DshΔDIX.B} NA P{sE-DshΔPDZ.B} NA P{sev-dsh.T} NA characterization construct P{Car7E} NA P{Car7EX} NA P{dppw} NA P{dsh.EGFP} NA P{dsh.HindIII} NA P{dsh.KR.E.2x.GFP} NA P{dsh.KR.E.5x.GFP} NA P{dsh.Q27} NA P{dsh.Q108} NA P{dsh.ΔQ} NA P{dsh1.tAa} NA P{dsh1.EGFP} NA P{dshT:Hsap\MYC} NA P{dsh-eGFP.C-term1-2} NA P{dsh-eGFP.C-term1-3} NA P{dsh-eGFP.C-term2-3} NA P{dsh-eGFP.C-term2} NA P{dsh-eGFP.C-term5Y-F} NA P{dsh-eGFP.DEP6A} NA P{dsh-eGFP.K417R} NA P{dsh-eGFP.S254A} NA P{dsh-eGFP.S266A} NA P{dsh-eGFP.S271A} NA P{dsh-eGFP.S283A} NA P{dsh-eGFP.S406A} NA P{dsh-eGFP.S406E} NA P{dsh-eGFP.S451A} NA P{dsh-eGFP.S451E} NA P{dsh-eGFP.S469A} NA P{dsh-eGFP.T36A} NA P{dsh-eGFP.T252A} NA P{dsh-eGFP.T314A} NA P{dsh-eGFP.T349A} NA P{dsh-eGFP.T419A} NA P{dsh-eGFP.T419E} NA P{dsh-eGFP.T462A} NA P{dsh-eGFP.T467A} NA P{dsh-eGFP.Y24F} NA P{dsh-eGFP.Y280F} NA P{dsh-eGFP.Y473F} NA P{dsh-eGFP.Y474F} NA P{dsh-eGFP.ΔC} NA P{dsh-FLAG} NA P{dsh-GFP.ST5} NA P{dsh-GFP.ST8} NA P{sev-dsh.U} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}dshG0267 No
Gene Ontology: Function, Process & Cellular Component ( 46 unique terms )
Terms Based on Experimental Evidence ( 29 terms )
Molecular Function
CV term Evidence References
phosphatidic acid binding inferred from direct assay (Simons et al., 2009)
Biological Process
CV term Evidence References
axon extension inferred from mutant phenotype (Srahna et al., 2006) border follicle cell migration inferred from mutant phenotype (Bastock and Strutt, 2007) cellular component movement inferred from mutant phenotype (Cohen et al., 2002) compound eye morphogenesis inferred from mutant phenotype (Tomlinson, 2003) dorsal closure inferred from mutant phenotype (Kaltschmidt et al., 2002) dorsal closure, elongation of leading edge cells inferred from mutant phenotype (Kaltschmidt et al., 2002) epidermis morphogenesis inferred from mutant phenotype (Kaplan and Tolwinski, 2010) establishment of epithelial cell apical/basal polarity inferred from mutant phenotype (Ma et al., 2003) establishment of epithelial cell planar polarity inferred from mutant phenotype (Kaplan and Tolwinski, 2010) establishment of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Lee and Treisman, 2004, Strutt et al., 2006) establishment of ommatidial planar polarity inferred from genetic interaction with fz (Strutt et al., 2006) inferred from mutant phenotype (Zheng et al., 1995) female gonad development inferred from mutant phenotype (Cohen et al., 2002) filopodium assembly inferred from mutant phenotype (Kaltschmidt et al., 2002) heart formation inferred from mutant phenotype (Park et al., 1996) imaginal disc-derived wing hair organization inferred from genetic interaction with ck (Winter et al., 2001) inferred from genetic interaction with fz (Winter et al., 2001) inferred from genetic interaction with rok (Winter et al., 2001) inferred from genetic interaction with zip (Winter et al., 2001) inferred from mutant phenotype (Lee and Treisman, 2004) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Buratovich and Wilder, 2001) lamellipodium assembly inferred from mutant phenotype (Kaltschmidt et al., 2002) negative regulation of heart induction by canonical Wnt receptor signaling pathway inferred from mutant phenotype (Park et al., 1996) oogenesis inferred from mutant phenotype (Song and Xie, 2003) ovarian follicle cell development inferred from mutant phenotype (Jordan et al., 2006, Kirilly et al., 2005) regulation of actin filament bundle assembly inferred from genetic interaction with rok (Winter et al., 2001) regulation of compound eye pigmentation inferred from mutant phenotype (Lim and Tomlinson, 2006) regulation of tube length, open tracheal system inferred from mutant phenotype (Chung et al., 2009) retinal ganglion cell axon guidance inferred from mutant phenotype (Sato et al., 2006) salivary gland morphogenesis inferred from mutant phenotype (Harris and Beckendorf, 2007) somatic stem cell maintenance inferred from mutant phenotype (Kirilly et al., 2005, Song and Xie, 2003) wing and notum subfield formation inferred from mutant phenotype (Mohit et al., 2006)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Strutt et al., 2006)
Terms Based on Predictions or Assertions ( 20 terms )
Molecular Function
CV term Evidence References
Notch binding non-traceable author statement (Martinez Arias, 2002) signal transducer activity inferred from electronic annotation with InterPro:IPR001158, InterPro:IPR008339 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
dorsal closure traceable author statement (Harden, 2002) establishment of planar polarity traceable author statement (Torban et al., 2004, McNeill, 2002, Mlodzik, 2002) establishment of thoracic bristle planar orientation traceable author statement (Tree et al., 2002) establishment of tissue polarity non-traceable author statement (Van Aelst and Symons, 2002) traceable author statement (Noselli and Agnes, 1999) establishment or maintenance of cell polarity non-traceable author statement (Swiss-Prot Project Members, 2001.8.20) heart development non-traceable author statement (Cripps and Olson, 2002) traceable author statement (Chen and Fishman, 2000) imaginal disc-derived wing morphogenesis traceable author statement (Cadigan, 2002) intracellular signal transduction inferred from electronic annotation with InterPro:IPR000591 (FlyBase Curators et al., 2004-) ommatidial rotation non-traceable author statement (Van Aelst and Symons, 2002) oogenesis traceable author statement (Perrimon et al., 1986) protein localization traceable author statement (Cadigan, 2002) R3/R4 cell fate commitment non-traceable author statement (Mlodzik, 2002) sensory organ development non-traceable author statement (Martinez Arias, 2002) Wnt receptor signaling pathway non-traceable author statement (FlyBase, 1992-, Van Aelst and Symons, 2002, Swiss-Prot Project Members, 2001.8.20, Harden, 2002, Wedlich, 2002) traceable author statement (Chen and Fishman, 2000, Marsh and Theisen, 1999) Wnt receptor signaling pathway, planar cell polarity pathway inferred from biological aspect of ancestor with PANTHER:PTN000093831 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component
CV term Evidence References
adherens junction traceable author statement (Van Aelst and Symons, 2002) cell cortex inferred from biological aspect of ancestor with PANTHER:PTN000093831 (assigned by RefGenome) (Gaudet et al., 2010) cytoplasm non-traceable author statement (Swiss-Prot Project Members, 2001.8.20) traceable author statement (Van Aelst and Symons, 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dsh - Bap60 experimental knowledge based (Guruharsha et al., 2011) dsh - CG11505 experimental knowledge based (Guruharsha et al., 2011) dsh - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - CG14480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - CG17002 experimental knowledge based (Guruharsha et al., 2011) dsh - CG2017 experimental knowledge based (Guruharsha et al., 2011) dsh - CG3008 experimental knowledge based (Guruharsha et al., 2011) dsh - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - CG32479 experimental knowledge based (Guruharsha et al., 2011) dsh - CG34159 experimental knowledge based (Guruharsha et al., 2011) dsh - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - CG7185 experimental knowledge based (Guruharsha et al., 2011) dsh - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - Cdk8 experimental knowledge based (Guruharsha et al., 2011) dsh - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - MED10 experimental knowledge based (Guruharsha et al., 2011) dsh - MED11 experimental knowledge based (Guruharsha et al., 2011) dsh - MED14 experimental knowledge based (Guruharsha et al., 2011) dsh - MED15 experimental knowledge based (Guruharsha et al., 2011) dsh - MED16 experimental knowledge based (Guruharsha et al., 2011) dsh - MED17 experimental knowledge based (Guruharsha et al., 2011) dsh - MED18 experimental knowledge based (Guruharsha et al., 2011) dsh - MED20 experimental knowledge based (Guruharsha et al., 2011) dsh - MED23 experimental knowledge based (Guruharsha et al., 2011) dsh - MED25 experimental knowledge based (Guruharsha et al., 2011) dsh - MED27 experimental knowledge based (Guruharsha et al., 2011) dsh - MED30 experimental knowledge based (Guruharsha et al., 2011) dsh - MED4 experimental knowledge based (Guruharsha et al., 2011) dsh - MED6 experimental knowledge based (Guruharsha et al., 2011) dsh - MED7 experimental knowledge based (Guruharsha et al., 2011) dsh - MED8 experimental knowledge based (Guruharsha et al., 2011) dsh - Pa1 experimental knowledge based (Guruharsha et al., 2011) dsh - Psi experimental knowledge based (Guruharsha et al., 2011) dsh - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - Snr1 experimental knowledge based (Guruharsha et al., 2011) dsh - Ssdp experimental knowledge based (Guruharsha et al., 2011) dsh - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - boca experimental knowledge based (Guruharsha et al., 2011) dsh - brm experimental knowledge based (Guruharsha et al., 2011) dsh - ebi experimental knowledge based (Guruharsha et al., 2011) dsh - enc experimental knowledge based (Guruharsha et al., 2011) dsh - fan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dsh - ix experimental knowledge based (Guruharsha et al., 2011) dsh - l(2)gl anti tag coimmunoprecipitation, western blot (Kaplan and Tolwinski, 2010) dsh - mor experimental knowledge based (Guruharsha et al., 2011) dsh - osa experimental knowledge based (Guruharsha et al., 2011) dsh - ptip experimental knowledge based (Guruharsha et al., 2011) dsh - sano anti tag coimmunoprecipitation, anti tag western blot, two hybrid (Chung et al., 2009) dsh - sec24 experimental knowledge based (Guruharsha et al., 2011) dsh - skd experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dsh allele Gene References dsh1 ck (Winter et al., 2001) E(spl)mβ-HLH (Cooper and Bray, 1999) fz (Winter et al., 2001, Lee and Adler, 2002, Strutt and Strutt, 2003) in (Lee and Adler, 2002) Jra (Boutros et al., 1998) Mbs (Lee and Treisman, 2004) Moe (Speck et al., 2003) pk (Jenny et al., 2003) Rac1 (Fanto et al., 2000) Rho1 (Boutros et al., 1998) rok (Winter et al., 2001) sqh (Winter et al., 2001) zip (Winter et al., 2001) dsh3 arm (Greaves et al., 1999) CycE (Brumby et al., 2004) ds (Rodriguez, 2004) fz (Zhang and Carthew, 1998, Wu et al., 2004) nkd (Zeng et al., 2000) pk (Jenny et al., 2003) dsh4 sgl (Haerry et al., 1997) wg (Haerry et al., 1997) dsh6 CycE (Brumby et al., 2004) dsh477 nkd (Zeng et al., 2000) dshb117 arm (Greaves et al., 1999) dshhs.PA dx (Ramain et al., 2001) fz (Lee and Adler, 2002) N (Ramain et al., 2001) wg (Park et al., 1996) dshhs.sev.B bsk (Boutros et al., 1998, Paricio et al., 1999) Dl (Fanto and Mlodzik, 1999) ex (Blaumueller and Mlodzik, 2000) hep (Boutros et al., 1998, Paricio et al., 1999) Jra (Boutros et al., 1998) msn (Paricio et al., 1999) N (Fanto and Mlodzik, 1999) Rho1 (Boutros et al., 1998) dshScer\UAS.cAa arr (Wehrli et al., 2000) Axn (Cliffe et al., 2003) fy (Lee and Adler, 2002) hep (Kaltschmidt et al., 2002) in (Lee and Adler, 2002) mam (Helms et al., 1999) nkd (Rousset et al., 2001) dshScer\UAS.cNa bsk (Strutt et al., 1997) Rho1 (Strutt et al., 1997) wg (Neumann and Cohen, 1996) dshScer\UAS.T:Hsap\MYC Axn (Penton et al., 2002) dshT:Avic\GFP-EGFP fz (Wu et al., 2004) dshunspecified fz (Winter et al., 2001) pk (Gubb et al., 1999) wg (Theisen et al., 1994) dshw sgl (Haerry et al., 1997) wg (Theisen et al., 1994, Haerry et al., 1997) dshΔDEP+.Scer\UAS hep (Kaltschmidt et al., 2002) dshΔDIX.Scer\UAS hep (Kaltschmidt et al., 2002) unspecified bsk (Srahna et al., 2006) btl (Srahna et al., 2006) CG17278 (Mohit et al., 2006) cno (Yamamoto et al., 1997) Cyp310a1 (Mohit et al., 2006) dco (Klein et al., 2006) dgo (Jenny et al., 2005) Dl (Axelrod et al., 1996) fz (Strutt et al., 2006, Strutt et al., 1997) H (Mueller et al., 2005) hep (Srahna et al., 2006) L (Singh et al., 2006) M(UAS-dsh)8-3 (Penton et al., 2002) M(UAS-dsh)8-4 (Penton et al., 2002) N (Axelrod et al., 1996) nkd (Waldrop et al., 2006) pygo (Cadigan, 2002.1.24) Rac1 (Srahna et al., 2006, Boutros et al., 1998) Rac2 (Boutros et al., 1998) sha (Ren et al., 2006) shg (Greaves et al., 1999) tow (Chung et al., 2007) Vang (Wolff and Rubin, 1997) W (Mueller et al., 2005) wg (Axelrod et al., 1996) Wnt5 (Srahna et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58490 DroID - A comprehensive database of gene and protein interactions. • FBgn0000499 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32078 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P51140
Orthologs
OrthoDB Orthologs (53) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XH0JW Dipteran inclusive ortholog search EOG6RV30V Insect inclusive ortholog search EOG615F8F Arthropod inclusive ortholog search EOG6R228X Metazoa inclusive ortholog search EOG6VQPGG
Orthologs in Drosophila Species (EOG6XH0JW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dsh     Drosophila sechellia   Dsec\GM11474 Y   Drosophila erecta   Dere\GG18408 Y   Drosophila yakuba   Dyak\GE15927 Y   Drosophila ananassae   Dana\GF21769 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14904 Y   Drosophila persimilis   Dper\GL14851 Y   Drosophila willistoni   Dwil\GK25610 Y   Drosophila virilis   Dvir\GJ15240 Y   Drosophila mojavensis   Dmoj\GI15711 Y   Drosophila grimshawi   Dgri\GH12181 Y
Orthologs in non-Drosophila Dipterans (EOG6RV30V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008234   Anopheles gambiae Malaria mosquito  Agam\AGAP004448   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016589
Orthologs in non-Dipteran Insects (EOG615F8F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53849   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001052   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22423   Atta cephalotes Leafcutter ant  Acep\ACEP23557   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22131   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22971   Linepithema humile Argentine ant  Lhum\LH11614   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13083   Solenopsis invicta Red fire ant  Sinv\SINV21219   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007109   Bombyx mori Silkmoth  Bmor\BGIBMGA012189   Pediculus humanus Human body louse  Phum\PHUM575280   Tribolium castaneum Red flour beetle  Tcas\GLEAN_14903
Orthologs in non-Insect Arthropods (EOG6R228X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Ixodes scapularis Deer tick  Isca\ISCW005035
Orthologs in non-Arthropod Metazoa (EOG6VQPGG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dsh-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025646gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027671gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027672gn   Danio rerio Zebrafish  Drer\dvl1a   Danio rerio Zebrafish  Drer\dvl3   Danio rerio Zebrafish  Drer\dvl1b   Danio rerio Zebrafish  Drer\dvl2   Danio rerio Zebrafish  Drer\ENSDARG00000002148   Danio rerio Zebrafish  Drer\ENSDARG00000095919   Xenopus tropicalis Western clawed frog  Xtro\dvl2   Xenopus tropicalis Western clawed frog  Xtro\dvl3   Xenopus tropicalis Western clawed frog  Xtro\dvl1   Gallus gallus Domestic chicken  Ggal\DVL1   Gallus gallus Domestic chicken  Ggal\DVL3   Mus musculus House mouse  Mmus\Dvl1   Mus musculus House mouse  Mmus\Dvl2   Mus musculus House mouse  Mmus\Dvl3   Rattus norvegicus Norway rat  Rnor\Dvl1   Rattus norvegicus Norway rat  Rnor\Dvl2   Rattus norvegicus Norway rat  Rnor\Dvl3   Homo sapiens Human  Hsap\DVL3   Homo sapiens Human  Hsap\ENSG00000107404   Homo sapiens Human  Hsap\DVL2
Human Orthologs (3)
Gene OMIM HGNC Hsap\DVL3     Hsap\ENSG00000107404     Hsap\DVL2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17017 Drosophila sechellia Dsec\GM11474 Drosophila erecta Dere\GG18408 Drosophila yakuba Dyak\GE15927 Drosophila ananassae Dana\GF21769 Drosophila pseudoobscura pseudoobscura Dpse\GA14904 Drosophila persimilis Dper\GL14851 Drosophila willistoni Dwil\GK25610 Drosophila virilis Dvir\GJ15240 Drosophila mojavensis Dmoj\GI15711 Drosophila grimshawi Dgri\GH12181
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Bloomington	9454 dshA3 5298 w1 dsh1 5297 wa dsh6/FM7a 9453 w*; P{UAS-dsh.myc}1-16 41774 w*; P{dsh-eGFP.K417R}A1-3 25385 w*; P{dshT:Hsap\MYC}28.2 6331 w* dsh3 P{neoFRT}19A/FM7a 9521 w118; P{UAS-dsh8-1.myc}3-8 9519 w118; P{UAS-dsh8-65.myc}3-8
Kyoto	108156 dsh6/FM7a 108157 w1 dsh1
VDRC	v101525 P{KK108967}VIE-260B
	More stocks available...
Genomic Clones ( 1 )
	BACR28L07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD20984
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM05450 GM06970 LD04607 LD05177 LD08721 LD08827 LD22434 LD30990 LD30993 LD33581 LP11953 RE16325 RE16902 RE22834 RE23028 RE23257 RE34664 RE35521 RE37630 RE65283 RE69087 RE69657 RH61883 SD11167
Other clones	105112 bs59a07 CK01.27B.G6 CK01.50A.B4 CK01.65B.F1 CK01.121B.F7 EK053109 EK053121 EK062929 EK102418 EK174336 EK182752 EK230229 EN12933 LD18352 LD32934
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000499 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32078
Antibody Information
	polyclonal (Peradziryi et al., 2011, Yanfeng et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dsh CG1720 (Zhong, 1999.11)
Source for database merge of	Source for merge of: dsh CG18361 (FlyBase, 1996-) Source for merge of: dsh l(1)G0267 (Peter et al., 2002)
Additional comments	Source for merge of dsh CG18361 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Klein et al., 2006) During development of the bristle lineage, Vang acts in the dividing sensillum precursor cells to exclude raps from the posterior cortex. (Bellaiche et al., 2004) dsh has a role in relocating Axn to the plasma membrane during wg signalling. (Cliffe et al., 2003) The Vang/pk complex appears to modulate fz/dsh activity, resulting in a symmetry-breaking step during polarity signalling. (Jenny et al., 2003) dsh is necessary for the dorsal-ventral polarization of leading edge cells early in dorsal closure, in the absence of which actin-cable assembly and actin-based cell process formation fails to occur properly in these cells. (Kaltschmidt et al., 2002) Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. (Lee and Adler, 2002) Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy. (Lee and Adler, 2002) dsh functions in both fz and fz2 signalling, but distinct dsh protein domains feature in the two pathways. Genetic and over-expression assays show that dsh protein activates JNK cascades. (Boutros et al., 1998) fz-mediated signalling provides polarity information to pI, specifying the orientation of mitotic spindles. The orientations of the pIIa and pIIb divisions are independent of fz signalling and are instead defined by the axis of the previous pI division. (Gho and Schweisguth, 1998) dsh activity suppresses dpp expression and promotes wg expression in the imaginal discs. (Heslip et al., 1997) Genetic interactions indicate that Rho1 has a role in signalling mediated by dsh. (Strutt et al., 1997) Planar polarity phenotypes of loss of function and overexpression of fz in the developing eye is studied, the phenotype is almost identical to loss of function or overexpression of dsh. (Tomlinson et al., 1997) Casein kinase II (encoded by CkIIα and CkIIβ) phosphorylates dsh in vitro. This phosphorylation is regulated by fz2, implicating a role for Casein kinase II in wg signalling. (Willert et al., 1997) dsh interacts antagonistically with N and Dl. A physical interaction of the dsh product with the carboxy terminus of that of N suggests a basis for the interaction. Thus dsh, in addition to transducing wg signal, blocks N signalling directly, explaining the inhibitory cross talk observed between the pathways. (Axelrod et al., 1996) The segment polarity phenotype of dsh mutant embryos is substantially rescued by Mmus\Dvl2. Normal segmentation is largely restored while restoration of the head skeleton is only partially rescued. (Klingensmith et al., 1996) dsh and arm, but not sgg are required for heart formation. Overexpression of dsh causes hypertrophy of heart precursors and rescues the heart and CNS deficit of wg mutants. (Park et al., 1996) dsh mutations mimic all effects of a wg mutation. sgg, dsh and arm function to transmit the wg signal in the midgut in the same way as they do in the epidermis. Results suggest the wg signal transduction pathway acts in all three germ layers, the ectoderm, mesoderm and endoderm. (Yu et al., 1996) wg is expressed in a narrow stripe at the wing margin, dsh is required in the cells responding to wg. Clones of dsh mutant tissue at the wing margin can block the response to wg. The wg signal can traverse several cell diameters of mutant tissue to reach responsive wing cells. Overexpression of dsh potentiates the response to wg, bristle formation is induced large distances from the site of wg expression. wg can signal over a large distance in a sensitized background. (Axelrod et al., 1995) The dsh gene product is required for wg-dependent bristle inhibition, but is not absolutely essential for wg signalling in the eye. (Cadigan and Nusse, 1995) Clones of dsh mutant cells cause pattern duplications which mimic duplications caused by loss of wg function. (Heslip et al., 1995) dsh function is required for endogenous fz activity. fz activity is directly proportional to dsh gene dosage. (Krasnow et al., 1995) dsh gene is indispensable for the transmission of the wg signal in distinct cells. (Wodarz and Nusse, 1995) dsh is not merely a permissive factor in wg signalling but encodes a novel signal transduction molecule which may function between the wg receptor and more downstream signaling molecules. (Yanagawa et al., 1995) arm, dsh and sgg encode elements of a unique wg signalling pathway that is used several times throughout development. (Couso et al., 1994) The dsh gene product represents a novel signal transduction molecule generally required for the target cells to the wg signal. (Klingensmith et al., 1994) wg acts through dsh and arm to affect the expression of en and cuticle differentiation. (Noordermeer et al., 1994) dsh and por act upstream of sgg, and arm acts downstream of sgg in the wg signalling pathway. dsh acts upstream of sgg. (Siegfried et al., 1994) dsh is required during wg signalling to establish both cell polarity and cell identity. (Theisen et al., 1994) wg and en expression patterns are studied in all known segment polarity mutants to investigate the requirement of other segment polarity genes in mediating the maintenance of wg and en. (van den Heuvel et al., 1993) Phenotypic and mosaic analysis of dsh reveals functions in cellular responses to multiple positional signalling mechanisms in epidermal development. (Klingensmith and Perrimon, 1992) The role of segment polarity genes in arm protein accumulation has been investigated. wg regulates accumulation of arm by posttranscriptional control, por and dsh are also required for this effect. (Riggleman et al., 1990) Most alleles lethal, but dsh1, although poorly viable as homozygous females or hemizygous males, appears to be fully viable when heterozygous to a deficiency for the region, suggesting that the reduced viability is unrelated to dsh1. dsh1 flies have deranged thoracic hairs, divergent and blistered wings and ellipsoid eyes. Leg bristles, hairs and bracts display high frequencies of abnormal polarity; extra joints or joint primordia found frequently in the first and second tarsal joints of the first and second pairs of legs; of 270 ectopic joints, 268 displayed inverted polarity [Held, Duarte and Derakhshanian, 1986). Males and females fertile, males weakly so. Homozygotes and hemizygotes for the lethal alleles die as second- to early-third instar larvae when derived from heterozygous mothers; when derived from homozygous germ-line clones, on the other hand, embryos with segment-polarity defects result; only ventral cuticle is present, covered with a lawn of setae; lack dorsal cuticle, posterior spiracles and filzkorper material. At six to seven hours maxillary and labial segments appear to be missing and parasegmental boundaries do not form; cell death apparent in vicinity of tracheal pits, which subsequently fuse; segmental boundaries fail to form; organization of central nervous system seems normal. Loss of cells of posterior segment compartments leads to discontinued production of en+ product. Viability of dsh1/dsh3, for example, when derived from homozygous dsh3 oogenic clones, is normal, indicating that dsh1 is wild type for the early function.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078563 RefSeq (Proteins) • NP_511118 DDBJ / EMBL / GenBank • AA978778 AAA16535 AAA20216 AAF48033 AAN09293 AAW57900 AAW57901 AAW57902 AAW57903 AAW57904 AAW57905 AAW57906 AAW57907 AAW57908 AAW57909 AAW57910 AAW57911 AAW57912 AAW57913 AAW57914 AAW57915 AAW57916 AAW57917 AAW57918 AAW57919 AAW57920 AAW57921 AAW57922 AJ426859 AY863528 AY863529 AY863530 AY863531 AY863532 AY863533 AY863534 AY863535 AY863536 AY863537 AY863538 AY863539 AY863540 AY863541 AY863542 AY863543 AY863544 AY863545 AY863546 AY863547 AY863548 AY863549 AY863550 L26974 U02491 Entrez Gene - A searchable database of RefSeq genes. • 32078 UniProtKB/Swiss-Prot • P51140 UniProtKB/TrEMBL • Q5G232 Q8IR91
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DEP domain (IPR000591) DIX domain (IPR001158) PDZ domain (IPR001478) Dishevelled protein domain (IPR003351) Dishevelled family (IPR008339) Winged helix-turn-helix DNA-binding domain (IPR011991) Dishevelled-related protein (IPR015506) Dishevelled Dsh (IPR026542)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58490 DroID - A comprehensive database of gene and protein interactions. • FBgn0000499 DRSC - Results from RNAi screens. • FBgn0000499 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000499 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18361-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000499 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 89432 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32078 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/dishevel.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32078 modMine - Data generated by the modENCODE project. • FBgn0000499 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P51140
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG1720   CG18361 (Keleman et al., 2009.8.5, Ni et al., 2008, Foley et al., 2010) Dm Dsh (Konikoff et al., 2010) Dsh (Torban et al., 2004, Wharton et al., 2006, Humbert et al., 2006, DasGupta et al., 2005, Chan et al., 2007, Wu and Mlodzik, 2007, Jenny et al., 2007, Singla, 2006, Quaiser, 2006, Singh et al., 2007, He and Axelrod, 2006, Mohit et al., 2006, Tolwinski, 2007, Chung et al., 2008, Jenny et al., 2008, Cong et al., 2004, Matsubayashi et al., 2004, Folwell et al., 2010, Sánchez et al., 2008, Le Garrec and Kerszberg, 2008, Canela-Xandri et al., 2008, Chan et al., 2008, Wodarz et al., 2006, Nagaraj and Banerjee, 2009, Strutt and Warrington, 2008, Wu et al., 2008, Ma et al., 2008, Buceta et al., 2007, Varelas et al., 2010, Usha and Shashidhara, 2010, Quijano et al., 2010, Weinmaster, 1997, Metcalfe et al., 2010, Mottola et al., 2010, Fiedler et al., 2011, Eivers et al., 2011, D'Hulst et al., 2006, Muñoz-Descalzo et al., 2010, Buechling et al., 2011, Quijano et al., 2011, Yanfeng et al., 2011) DSH (Tree et al., 2000, Takada et al., 2005) dsh (Singh et al., 2006, Lawrence et al., 2007, Djiane et al., 2005, Ren et al., 2006, Waldrop et al., 2006, Lim and Tomlinson, 2006, Joshi et al., 2006, Jafar-Nejad et al., 2006, Matusek et al., 2006, Strutt et al., 2006, Klein et al., 2006, Strutt and Strutt, 2005, Winter et al., 2001, Furlong, 2005, Bartscherer et al., 2006, Mirkovic and Mlodzik, 2006, Christensen and Cook, 2007.5.8, Christensen and Cook, 2007.5.8, Egger-Adam and Katanaev, 2010, Lim and Choi, 2004, Takada et al., 2005, Morais da Silva and Vincent, 2007, König T et al., 2007, Jenny et al., 2007, Gordon and Nusse, 2006, Todi et al., 2008, Colosimo and Tolwinski, 2006, Chung et al., 2007, Zhang et al., 2006, Bilic et al., 2007, Jordan et al., 2006, Mirkovic et al., 2011, Seto and Bellen, 2006, Ma et al., 2006, Jenny et al., 2005, Dahmann et al., 2008, Wu et al., 2008, Papadopoulou et al., 2004, Shimada et al., 2006, Sato et al., 2006, Fanto and McNeill, 2004, Harris and Beckendorf, 2007, Le Garrec et al., 2006, Macdonald and Long, 2005, Cho et al., 2011, Rawls et al., 2007, Yanfeng et al., 2011, Shimizu et al., 2011, Singh et al., 2010, Goossens et al., 2011, Zhu, 2009, Peng et al., 2012, Toku et al., 2011, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, del Alamo and Mlodzik, 2006, da Silva and Vincent, 2007, Bastock and Strutt, 2007, Strutt and Strutt, 2007, Chen et al., 2008, Baig-Lewis et al., 2007, Fiehler and Wolff, 2007, Inaki et al., 2007, Price et al., 2006, Miech et al., 2008, Cliffe et al., 2004, Strutt and Strutt, 2008, Steinel and Whitington, 2009, Lin et al., 2008, Ayroles et al., 2009, Simons et al., 2009, He and Adler, 2002, Gomes et al., 2009, Chiang et al., 2009, Xie et al., 2005, Blanco et al., 2009, Perea et al., 2009, Davidson et al., 2009, Glise et al., 2005, Jaiswal et al., 2006, Weber et al., 2008, Fetting et al., 2009, Popodi et al., 2010-, Hatton-Ellis et al., 2007, DasGupta et al., 2007, Chung et al., 2009, Doyle et al., 2008, Wang et al., 2010, Li et al., 2010, Varelas et al., 2010, Singh et al., 2010, Ho et al., 2010, Djiane and Mlodzik, 2010, Hermle et al., 2010, Pataki et al., 2010, Beltran et al., 2007, Kaplan and Tolwinski, 2010, Ségalen et al., 2010, Marsh et al., 2000, Matsubara et al., 2011, McElwain et al., 2011, Peradziryi et al., 2011, Mendoza-Topaz et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Venken et al., 2010, Kuroda et al., 2012, Weber et al., 2012, Capilla et al., 2012) Dvl (Stadeli, 2006) l(1)10Bd (Caggese et al., 1994, ) l(1)dsh (Perrimon and Mahowald, 1987) l(1)G17   l(1)G0267 (Schaefer et al., 1999.6.15, )
Name Synonym	disheveled (Colosimo and Tolwinski, 2006) Disheveled (Srahna et al., 2006, Yanfeng et al., 2011, Canela-Xandri et al., 2008) Dishevelled (Djiane et al., 2006, Leptin, 2005, Chan et al., 2007, Jenny et al., 2007, Heeg-Truesdell, 2006, Quaiser, 2006, Egger-Adam and Katanaev, 2010, Todi et al., 2008, Takada et al., 2005, Seto and Bellen, 2006, Strutt, 2005, Chung et al., 2008, Jenny et al., 2008, Wu et al., 2008, Hayward et al., 2005, Matsubayashi et al., 2004, Fanto and McNeill, 2004, Dawes-Hoang and Wieschaus, 2001, Marques, 2005, Lecuit and Le Goff, 2007, Strutt and Strutt, 2007, Chen et al., 2008, Inaki et al., 2007, Schweizer and Varmus, 2003, Strutt and Strutt, 2008, Lin et al., 2008, Simons et al., 2009, Mok et al., 2005, Gomes et al., 2009, Chung et al., 2009, Varelas et al., 2010, Weinmaster, 1997, Metcalfe et al., 2010, Mottola et al., 2010, Ségalen et al., 2010, Muñoz-Descalzo et al., 2010) dishevelled (Lawrence et al., 2007, Strutt and Strutt, 2005, Winter et al., 2001, Clevers, 2006, Morais da Silva and Vincent, 2007, Warrington and Strutt, 2007, Sato et al., 2006, Harris and Beckendorf, 2007, Le Garrec et al., 2006, Mrkusich et al., 2011, Folwell et al., 2010, Shimizu et al., 2011, da Silva and Vincent, 2007, Fiehler and Wolff, 2007, He and Adler, 2002, Blanco et al., 2009, Perea et al., 2009, Fetting et al., 2009, DasGupta et al., 2007, Wang et al., 2010, Li et al., 2010, Pataki et al., 2010, Weber et al., 2012) disshevelled (Chen and Fishman, 2000)
Secondary FlyBase IDs
	FBgn0027244 FBgn0042225
References ( 638 )
Generate a list of	All references relating to this gene ( 638 )
List References by type	Research paper  ( 310 ) Supplementary material  ( 7 ) Review  ( 191 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 95 ) FlyBase analysis  ( 2 ) Conference report  ( 10 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Letter  ( 2 ) Book  ( 1 ) Spoof  ( 1 ) Poem  ( 1 )
Recent research papers ( 22 )
	Warrington et al., 2013, Development 140(5): 1045--1054 The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2. [FBrf0220829] Capilla et al., 2012, Development 139(14): 2584--2593 Planar cell polarity controls directional Notch signaling in the Drosophila leg. [FBrf0218695] Kuroda et al., 2012, Mech. Dev. 128(11-12): 625--639 Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut. [FBrf0217619] Ng, 2012, Development 139(1): 165--177 Wnt/PCP proteins regulate stereotyped axon branch extension in Drosophila. [FBrf0216855] Peng et al., 2012, Dev. Cell 23(3): 507--518 Planar Polarized Protrusions Break the Symmetry of EGFR Signaling during Drosophila Bract Cell Fate Induction. [FBrf0219458] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Buechling et al., 2011, EMBO Rep. 12(12): 1265--1272 p24 proteins are required for secretion of Wnt ligands. [FBrf0216831] Cho et al., 2011, PLoS ONE 6(7): e22703 Wolbachia bacteria reside in host Golgi-related vesicles whose position is regulated by polarity proteins. [FBrf0214605] Donoughe and Dinardo, 2011, Development 138(13): 2751--2759 dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis. [FBrf0213896] Eivers et al., 2011, Sci. Signal. 4(194): ra68 Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling. [FBrf0216411] Fiedler et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(5): 1937--1942 Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating {beta}-catenin. [FBrf0212953] Goossens et al., 2011, Development 138(8): 1595--1605 The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. [FBrf0213316] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] McElwain et al., 2011, PLoS ONE 6(11): e26993 A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. [FBrf0216663] Mendoza-Topaz et al., 2011, Open Biol. 1(3): 110013 The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. [FBrf0218486] Mrkusich et al., 2011, Dev. Biol. 358(1): 224--230 The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo. [FBrf0215204] Peradziryi et al., 2011, EMBO J. 30(18): 3729--3740 PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. [FBrf0215241] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Shimizu et al., 2011, J. Neurosci. 31(13): 4944--4954 The wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron. [FBrf0213382] Strutt et al., 2011, Dev. Cell 20(4): 511--525 Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains. [FBrf0214246] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Yanfeng et al., 2011, Dev. Biol. 360(1): 132--142 Functional dissection of phosphorylation of Disheveled in Drosophila. [FBrf0216602] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...