FlyBase Gene Report: Dmel\dwg

General Information

Symbol

Dmel\dwg

Species

D. melanogaster

Name

deformed wings

Annotation Symbol

CG2711

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000520

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

deformed wings (dwg) encodes an architectural chromatin protein essential for embryonic development that organizes open chromatin in regulatory regions (predominantly promoters). dwg product binding site was found in the insulator encoded by scs, and its functions include enhancer blocking, support of distant interactions and recruitment of transcription factors. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

Zw5, l(1)zw5, zw-5, SBP, zeste-white 5

Key Links

Genomic Location

Cytogenetic map

3B3-3B3

Sequence location

X:2,727,698..2,730,042 [+]

Recombination map

1-1.5

RefSeq locus

NC_004354 REGION:2727698..2730042

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables chromatin insulator sequence binding

inferred from direct assay

(Blanton et al., 2003, Gaszner et al., 1999)

enables DNA binding

inferred from direct assay

(Krystel and Ayyanathan, 2013)

enables protein binding

inferred from physical interaction with FLYBASE:BEAF-32; FB:FBgn0015602

(Blanton et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR012934

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from biological aspect of ancestor with PANTHER:PTN002810793

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in chromatin

inferred from direct assay

(Blanton et al., 2003)

located_in nucleus

inferred from direct assay

(Gaszner et al., 1999)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from electronic annotation with InterPro:IPR012934

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

dwg: deformed wings

Most alleles lethal, dying during the first larval instar; the semilethal allele, dwg7, ceases development from the second instar on, with a few individuals surviving to adulthood. Lethal alleles (dwg4, dwg5, dwg6, and dwg8) can be recovered as males in combination with variegating duplications, Dp(1;3)N264-58, Dp(1;3)wm49a, and Dp(1;4)wm65g; have rough reduced dark eyes, sparse vibrissae, often missing orbital, ocellar, and vertical bristles, thickened wing veins, and incised inner wing margins; such males with a Y are fertile; XO males are not recovered at 25. Of these alleles only dwg7 survives as XO tissue in gynandromorphs; homozygous germ-line clones in females fail to produce eggs (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). dwg1 recorded as having broad, round tipped wings, with occasional marginal incisions and sometimes grossly deformed in shape and venation; extremely fine bristles, and small occasionally rough eyes. Surviving males with any allele are sterile.

*ves: vestigium

Wings abnormal, vary from small and curved to almost normal with cut-away inner margins. Eyes slightly rough and abnormally shaped. Male infertile; viability about 50% normal. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dwg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W4V9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dwg-RA

FBtr0070487

NM_057990

2002

592

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

dwg-PA

FBpp0070465

66.3

592

4.92

Q9W4V9

NP_477338

AAF45819

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

591 (aa)

(Gaszner et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dwg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dwg_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.70

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in chromatin

inferred from direct assay

(Blanton et al., 2003)

located_in nucleus

inferred from direct assay

(Gaszner et al., 1999)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dwg in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dwg

View exonic expression by tissue for Dmel\dwg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000520

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31265/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000520

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000520

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000520

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2711

Flygut - An atlas of the Drosophila adult midgut

FBgn0000520

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 49 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dwg

Transgenic constructs containing regulatory region of dwg

Aberrations (Deficiencies and Duplications) ( 63 )

Inferred from experimentation ( 63 )

Gene disrupted in

Df(1)62d18

(Judd et al., 1972)

Df(1)64c4

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)202

(Nomura and Kurokawa, 1997)

Df(1)BSC656

(Christensen et al., 2008.12.28)

Df(1)BSC710

(Christensen et al., 2008.12.28)

Df(1)HM3

(Kramers et al., 1983)

Df(1)HM406

(Kramers et al., 1983)

Df(1)JC19

(Blanton et al., 2003)

Df(1)N-264-58

(Judd et al., 1972)

Df(1)TEM1

(Kramers et al., 1991, Kramers et al., 1983, Lim and Snyder, 1974)

Df(1)TEM75

(Lim and Snyder, 1974)

Df(1)TEM202

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Liu and Lim, 1975)

Df(1)TEM501

(Kramers et al., 1991, Kramers et al., 1983, Lim and Snyder, 1974)

Df(1)w258-11

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)w258-42

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)w258-45

(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)w258-48

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)w¹²

(Cizeau et al., 1994)

Df(1)w-N71a

(Judd et al., 1972)

Df(1)w-rJ1

(Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Liu and Lim, 1975, Lim and Snyder, 1974, Judd et al., 1972)

Df(1)w-rJ2

(Judd et al., 1972)

Df(1)X12

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)z-deb65

(Goldberg et al., 1989)

Df(1)z-deb72

(Goldberg et al., 1989)

Df(1)z-deb511

(Goldberg et al., 1989)

Gene duplicated in

Dp(1;2;Y)w⁺

(Kramers et al., 1991, Kramers et al., 1983, Judd et al., 1972)

Dp(1;2)w⁺70h

(Judd et al., 1972)

Dp(1;3)N^264-58

(Judd et al., 1972)

Dp(1;3)w⁺67k

(Judd et al., 1972)

Dp(1;3)w^m49a

(Judd et al., 1972)

Dp(1;4)w^m65g

(Judd et al., 1972)

Dp(1;Y)w⁺y⁺

(Ferro, 2002.12)

Gene not disrupted in

Df(1)7

(Nomura and Kurokawa, 1997)

Df(1)62g18

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)64f1

(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)64j4

(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)65j26

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)304

(Nomura and Kurokawa, 1997)

Df(1)K95

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)L126

(Nomura and Kurokawa, 1997)

Df(1)N-8

(Kramers et al., 1991, Lin and Wolfner, 1989, Kramers et al., 1983)

Df(1)N-54l9

(Kramers et al., 1991)

Df(1)N-264-105

(Kramers et al., 1991)

Df(1)Pgd-kz

(Kramers et al., 1991)

Df(1)Sp2F-3A

(Schalet, 1986)

Df(1)TEM6

(Lim and Snyder, 1974)

Df(1)TEM7

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Liu and Lim, 1975, Lim and Snyder, 1974)

Df(1)TEM304

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Liu and Lim, 1975, Lim and Snyder, 1974)

Df(1)w55j

(Lin and Wolfner, 1989)

Df(1)w67k30

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)z-deb3

(Goldberg et al., 1989)

Df(1)z-deb42

(Goldberg et al., 1989)

Df(1)z-deb54

(Goldberg et al., 1989)

Df(1)z-deb59

(Goldberg et al., 1989)

Df(1)z-deb62

(Goldberg et al., 1989)

Df(1)z-deb81

(Goldberg et al., 1989)

Df(1)z-deb85

(Goldberg et al., 1989)

Df(1)z-deb87

(Goldberg et al., 1989)

Df(1)z-deb92

(Goldberg et al., 1989)

Df(1)z-deb311

(Goldberg et al., 1989)

Df(1)z-deb910

(Goldberg et al., 1989)

Gene not duplicated in

Dp(1;2)51b

(Kramers et al., 1991, Kramers et al., 1983)

Dp(1;3)w^vco

(Schalet, 1986)

Inferred from location ( 15 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | germline clone

dwg⁷

lethal | male limited, with Scer\GAL4^Bx-MS1096

dwg^{UAS.ORF.GW.Tag:HA}

lethal | male limited | cold sensitive, with Scer\GAL4^Bx-MS1096

dwg^{UAS.ORF.GW.Tag:HA}

lethal | recessive

lethal - all die before end of larval stage | recessive

dwg⁸

partially lethal

partially lethal | male

dwg²

partially lethal - majority die

viable

dwg¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dwg^GD1426

viable, with Scer\GAL4^Mef2.PR

dwg^GD1426

viable, with Scer\GAL4^pnr-MD237

dwg^GD1426

Sterility

Allele

male sterile

male sterile | recessive

dwg²

Other Phenotypes

Allele

some die during larval stage | recessive

dwg⁸

visible

visible | female limited, with Scer\GAL4^Bx-MS1096

dwg^{UAS.ORF.GW.Tag:HA}

visible | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

dwg^{UAS.ORF.GW.Tag:HA}

visible | recessive

dwg²

wild-type

dwg^Hsp83.PG

Phenotype manifest in

Allele

anterior orbital bristle

dwg⁷

eye

macrochaeta

dwg¹

middle orbital bristle

dwg⁷

ocellar bristle

dwg⁷

pigment cell

dwg⁷

posterior orbital bristle

dwg⁷

vertical bristle 1

dwg⁷

vertical bristle 2

dwg⁷

vibrissal bristle

dwg⁷

wing

wing | female limited, with Scer\GAL4^Bx-MS1096

dwg^{UAS.ORF.GW.Tag:HA}

wing | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

dwg^{UAS.ORF.GW.Tag:HA}

wing vein

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (353)

Hsap\ZNF92

3 of 14

Yes

Hsap\ZNF479

3 of 14

Yes

Hsap\ZNF680

3 of 14

Yes

Hsap\ZNF736

3 of 14

Yes

Hsap\ZNF737

3 of 14

Yes

Hsap\ERV3-1-ZNF117

2 of 14

Yes

Hsap\MZF1

2 of 14

Hsap\ZBTB11

2 of 14

Yes

Hsap\ZNF66

2 of 14

Yes

Hsap\ZNF85

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\ZNF208

2 of 14

Hsap\ZNF253

2 of 14

Hsap\ZNF257

2 of 14

Yes

Hsap\ZNF273

2 of 14

Hsap\ZNF324B

2 of 14

Yes

Hsap\ZNF430

2 of 14

Yes

Hsap\ZNF431

2 of 14

Yes

Hsap\ZNF460

2 of 14

Yes

Hsap\ZNF486

2 of 14

Yes

Hsap\ZNF492

2 of 14

Hsap\ZNF506

2 of 14

Yes

Hsap\ZNF546

2 of 14

Hsap\ZNF626

2 of 14

Hsap\ZNF628

2 of 14

Yes

Hsap\ZNF675

2 of 14

Yes

Hsap\ZNF679

2 of 14

Yes

Hsap\ZNF682

2 of 14

Yes

Hsap\ZNF708

2 of 14

Yes

Hsap\ZNF716

2 of 14

Yes

Hsap\ZNF724

2 of 14

Yes

Hsap\ZNF729

2 of 14

Hsap\ZNF732

2 of 14

Yes

Hsap\ZNF780B

2 of 14

Yes

Hsap\ZNF836

2 of 14

Hsap\ATMIN

1 of 14

Hsap\BACH1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\LOC344065

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZBTB6

1 of 14

Hsap\ZBTB7A

1 of 14

Hsap\ZBTB7B

1 of 14

Yes

Hsap\ZBTB16

1 of 14

Yes

Hsap\ZBTB17

1 of 14

Yes

Hsap\ZBTB18

1 of 14

Yes

Hsap\ZBTB20

1 of 14

Hsap\ZBTB24

1 of 14

Hsap\ZBTB42

1 of 14

Yes

Hsap\ZBTB43

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZFAT

1 of 14

Hsap\ZFP1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF37A

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF121

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF239

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF425

1 of 14

Hsap\ZNF426

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF517

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF653

1 of 14

Yes

Hsap\ZNF655

1 of 14

Yes

Hsap\ZNF658B

1 of 14

Hsap\ZNF658

1 of 14

Hsap\ZNF660

1 of 14

Hsap\ZNF660-ZNF197

1 of 14

Hsap\ZNF664

1 of 14

Yes

Hsap\ZNF665

1 of 14

Hsap\ZNF668

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF678

1 of 14

Hsap\ZNF681

1 of 14

Hsap\ZNF687

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\ZNF765-ZNF761

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZSCAN5B

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (74)

Rnor\Zfp668

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC102556092

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp251

1 of 14

Yes

Rnor\Zfp281

1 of 14

Yes

Rnor\Zfp287

1 of 14

Rnor\Zfp300

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp513

1 of 14

Yes

Rnor\Zfp617

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp951

1 of 14

Yes

Rnor\Zfp955a

1 of 14

Yes

Rnor\Zfp958

1 of 14

Rnor\Zkscan8

1 of 14

Yes

Rnor\Znf442

1 of 14

Yes

Rnor\Znf768

1 of 14

Yes

Rnor\Zscan10

1 of 14

Yes

Rnor\Zup1

1 of 14

Yes

Mus musculus (laboratory mouse) (157)

Mmus\5430403G16Rik

2 of 14

Yes

Mmus\Gm19965

2 of 14

Yes

Mmus\Gm45871

2 of 14

Yes

Mmus\Zfp60

2 of 14

Yes

Mmus\Zfp97

2 of 14

Yes

Mmus\Zfp324

2 of 14

Yes

Mmus\Zfp612

2 of 14

Yes

Mmus\Zfp616

2 of 14

Yes

Mmus\Zfp619

2 of 14

Yes

Mmus\Zfp768

2 of 14

Yes

Mmus\Zfp977

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm14412

1 of 14

Mmus\Gm14430

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rslcan18

1 of 14

Yes

Mmus\Zbtb11

1 of 14

Mmus\Zbtb43

1 of 14

Yes

Mmus\Zbtb44

1 of 14

Mmus\Zbtb49

1 of 14

Yes

Mmus\Zfp2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp119b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp286

1 of 14

Yes

Mmus\Zfp287

1 of 14

Yes

Mmus\Zfp317

1 of 14

Mmus\Zfp345

1 of 14

Mmus\Zfp354c

1 of 14

Yes

Mmus\Zfp358

1 of 14

Mmus\Zfp383

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp457

1 of 14

Mmus\Zfp472

1 of 14

Yes

Mmus\Zfp473

1 of 14

Mmus\Zfp513

1 of 14

Yes

Mmus\Zfp534

1 of 14

Mmus\Zfp560

1 of 14

Yes

Mmus\Zfp568

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp664

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp780b

1 of 14

Mmus\Zfp784

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp853

1 of 14

Mmus\Zfp867

1 of 14

Yes

Mmus\Zfp869

1 of 14

Yes

Mmus\Zfp871

1 of 14

Yes

Mmus\Zfp873

1 of 14

Mmus\Zfp882

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp940

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zscan2

1 of 14

Mmus\Zscan22

1 of 14

Mmus\Zup1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (92)

Xtro\tmem208

2 of 13

Yes

Xtro\ube2c

2 of 13

Yes

Xtro\asb8

1 of 13

Xtro\atmin

1 of 13

Xtro\bcl6

1 of 13

Yes

Xtro\cd36

1 of 13

Xtro\e4f1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ikzf1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100498520

1 of 13

Xtro\LOC101730779

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC105947126

1 of 13

Xtro\LOC108645295

1 of 13

Xtro\LOC108647923

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\prdm2

1 of 13

Yes

Xtro\prdm6

1 of 13

Yes

Xtro\prdm10

1 of 13

Yes

Xtro\prdm14

1 of 13

Xtro\prdm15

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\xlcgf26.1l

1 of 13

Yes

Xtro\zbtb18

1 of 13

Yes

Xtro\zbtb20

1 of 13

Yes

Xtro\zbtb39

1 of 13

Xtro\zbtb40

1 of 13

Yes

Xtro\zbtb41

1 of 13

Xtro\zbtb44

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\znf180

1 of 13

Xtro\znf205

1 of 13

Yes

Xtro\znf229

1 of 13

Xtro\znf281

1 of 13

Yes

Xtro\znf282

1 of 13

Xtro\znf292

1 of 13

Yes

Xtro\znf319

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (97)

Drer\zbtb47a

2 of 14

Yes

Drer\atmin

1 of 14

Drer\bcl6b

1 of 14

Yes

Drer\gb:ai877918

1 of 14

Yes

Drer\gtf3aa

1 of 14

Drer\gtf3ab

1 of 14

Drer\hic2

1 of 14

Yes

Drer\LOC568955

1 of 14

Yes

Drer\LOC797855

1 of 14

Yes

Drer\LOC100006216

1 of 14

Yes

Drer\LOC100149352

1 of 14

Yes

Drer\LOC100151570

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC108183927

1 of 14

Yes

Drer\LOC108183930

1 of 14

Drer\LOC110437722

1 of 14

Drer\LOC110437786

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:cabz01069022.1

1 of 14

Yes

Drer\si:ch73-138e16.4

1 of 14

Drer\si:ch73-138e16.6

1 of 14

Yes

Drer\si:ch73-144d13.4

1 of 14

Yes

Drer\si:ch73-266f23.4

1 of 14

Yes

Drer\si:ch73-299h12.6

1 of 14

Yes

Drer\si:ch73-347e22.4

1 of 14

Yes

Drer\si:ch73-367f21.6

1 of 14

Drer\si:ch211-142b24.6

1 of 14

Yes

Drer\si:ch211-161m3.6

1 of 14

Drer\si:ch211-207i20.2

1 of 14

Yes

Drer\si:ch211-229l10.11

1 of 14

Drer\si:ch211-261d7.6

1 of 14

Yes

Drer\si:ch211-276c2.4

1 of 14

Drer\si:dkey-14d8.1

1 of 14

Yes

Drer\si:dkey-33c14.6

1 of 14

Drer\si:dkey-34m19.3

1 of 14

Drer\si:dkey-89b17.4

1 of 14

Yes

Drer\si:dkey-201g16.1

1 of 14

Yes

Drer\si:dkey-208k4.2

1 of 14

Drer\si:zfos-932h1.3

1 of 14

Drer\zbtb2b

1 of 14

Yes

Drer\zbtb8b

1 of 14

Yes

Drer\zbtb12.1

1 of 14

Yes

Drer\zbtb37

1 of 14

Yes

Drer\zbtb43

1 of 14

Yes

Drer\zbtb44

1 of 14

Yes

Drer\zgc:113209

1 of 14

Drer\zgc:113294

1 of 14

Yes

Drer\zgc:136308

1 of 14

Yes

Drer\zgc:171422

1 of 14

Yes

Drer\zgc:173619

1 of 14

Yes

Drer\zgc:173720

1 of 14

Drer\zgc:173726

1 of 14

Yes

Drer\zgc:174268

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\znf408

1 of 14

Yes

Drer\znf513a

1 of 14

Yes

Drer\znf526

1 of 14

Yes

Drer\znf569l

1 of 14

Drer\znf652

1 of 14

Yes

Drer\znf982

1 of 14

Drer\znf1014

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\znf1179

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\blmp-1

1 of 14

Yes

Cele\che-1

1 of 14

Yes

Cele\egl-43

1 of 14

Yes

Cele\F47E1.20

1 of 14

Yes

Cele\F58G1.2

1 of 14

Yes

Cele\klu-1

1 of 14

Yes

Cele\lin-29

1 of 14

Yes

Cele\M03D4.4

1 of 14

Yes

Cele\mnm-2

1 of 14

Yes

Cele\pat-9

1 of 14

Yes

Cele\R10E4.11

1 of 14

Yes

Cele\set-17

1 of 14

Yes

Cele\tra-4

1 of 14

Yes

Cele\zag-1

1 of 14

Yes

Cele\ztf-1

1 of 14

Yes

Cele\ztf-23

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (64)

Agam\AgaP_AGAP001132

2 of 12

Yes

Agam\AgaP_AGAP000141

1 of 12

Agam\AgaP_AGAP000164

1 of 12

Agam\AgaP_AGAP000286

1 of 12

Yes

Agam\AgaP_AGAP001258

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010926

1 of 12

Agam\AgaP_AGAP011403

1 of 12

Yes

Agam\AgaP_AGAP011404

1 of 12

Yes

Agam\AgaP_AGAP011405

1 of 12

Agam\AgaP_AGAP011406

1 of 12

Agam\AgaP_AGAP011407

1 of 12

Yes

Agam\AgaP_AGAP011408

1 of 12

Yes

Agam\AgaP_AGAP011409

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011759

1 of 12

Agam\AgaP_AGAP012027

1 of 12

Yes

Agam\AgaP_AGAP012110

1 of 12

Agam\AgaP_AGAP012546

1 of 12

Yes

Agam\AgaP_AGAP012704

1 of 12

Yes

Agam\AgaP_AGAP012741

1 of 12

Agam\AgaP_AGAP012835

1 of 12

Agam\AgaP_AGAP013275

1 of 12

Arabidopsis thaliana (thale-cress) (52)

Atha\AT1G02030

1 of 13

Yes

Atha\AT1G14580

1 of 13

Yes

Atha\AT1G26590

1 of 13

Yes

Atha\AT1G26610

1 of 13

Yes

Atha\AT1G49900

1 of 13

Yes

Atha\AT2G28200

1 of 13

Yes

Atha\AT2G28710

1 of 13

Yes

Atha\AT2G45120

1 of 13

Yes

Atha\AT3G10470

1 of 13

Yes

Atha\AT3G29340

1 of 13

Yes

Atha\AT3G45260

1 of 13

Yes

Atha\AT3G46070

1 of 13

Yes

Atha\AT3G46080

1 of 13

Yes

Atha\AT3G49930

1 of 13

Yes

Atha\AT3G53600

1 of 13

Yes

Atha\AT3G60580

1 of 13

Yes

Atha\AT4G04404

1 of 13

Yes

Atha\AT5G03510

1 of 13

Yes

Atha\AT5G04390

1 of 13

Yes

Atha\AT5G15480

1 of 13

Yes

Atha\AT5G22890

1 of 13

Yes

Atha\AT5G56200

1 of 13

Yes

Atha\AT5G60470

1 of 13

Yes

Atha\AT5G61470

1 of 13

Yes

Atha\DAZ1

1 of 13

Yes

Atha\DAZ2

1 of 13

Yes

Atha\DOT5

1 of 13

Yes

Atha\IDD1

1 of 13

Yes

Atha\IDD4

1 of 13

Yes

Atha\IDD5

1 of 13

Yes

Atha\IDD7

1 of 13

Yes

Atha\IDD11

1 of 13

Yes

Atha\IDD12

1 of 13

Yes

Atha\IDD14

1 of 13

Yes

Atha\IDD16

1 of 13

Yes

Atha\JKD

1 of 13

Yes

Atha\MGP

1 of 13

Yes

Atha\NUC

1 of 13

Yes

Atha\RHL41

1 of 13

Yes

Atha\SGR5

1 of 13

Yes

Atha\STOP1

1 of 13

Yes

Atha\STZ

1 of 13

Yes

Atha\TFIIIA

1 of 13

Yes

Atha\TT1

1 of 13

Yes

Atha\WIP4

1 of 13

Yes

Atha\YY1

1 of 13

Yes

Atha\ZAT6

1 of 13

Yes

Atha\ZAT7

1 of 13

Yes

Atha\ZAT11

1 of 13

Yes

Atha\ZF1

1 of 13

Yes

Atha\ZF2

1 of 13

Yes

Atha\ZF3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\MIG2

1 of 13

Yes

Scer\MIG3

1 of 13

Yes

Scer\ZAP1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dwg. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (78)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

az2

1 of 13

Blimp-1

1 of 13

bowl

1 of 13

Cf2

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

idc

1 of 13

Imzf

1 of 13

jim

1 of 13

Kah

1 of 13

M1BP

1 of 13

MTF-1

1 of 13

Nnk

1 of 13

nom

1 of 13

odd

1 of 13

ouib

1 of 13

Phs

1 of 13

prg

1 of 13

ranshi

1 of 13

rgr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sqz

1 of 13

Sry-δ

1 of 13

trabl

1 of 13

Zaf1

1 of 13

Zif

1 of 13

ZIPIC

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ZNF92; zinc finger protein 92

3 of 14

603974

ZNF479; zinc finger protein 479

3 of 14

617444

ZNF680; zinc finger protein 680

3 of 14

ZNF736; zinc finger protein 736

3 of 14

ZNF737; zinc finger protein 737

3 of 14

603984

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

dwg

cross-linking study, pull down, molecular weight estimation by staining, anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Bonchuk et al., 2021, Zolotarev et al., 2016)

dwg - Atg8a

two hybrid, anti tag coimmunoprecipitation, anti tag western blot, pull down

(Kołodziej et al., 2024, Tang et al., 2023, Hu et al., 2017.6.13)

dwg - CG14441

two hybrid array

(Shokri et al., 2019)

dwg - CG2712

pull down, molecular weight estimation by staining

(Bonchuk et al., 2021)

dwg - eEF1α1

pull down, Identification by mass spectrometry, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Zolotarev et al., 2016)

dwg - mrn

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

BEAF-32

suppressible

dwg

(Blanton et al., 2003)

BEAF-32

enhanceable

dwg

(Blanton et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57796

DroID - A comprehensive database of gene and protein interactions.

FBgn0000520

MIST (genetic) - An integrated Molecular Interaction Database

31265

MIST (protein-protein) - An integrated Molecular Interaction Database

31265

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-1.5

Cytogenetic map

3B3-3B3

Sequence location

X:2,727,698..2,730,042 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3B3-3B3

Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dnc^EP1395

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

3C1-3C1

(Gaszner, 1999.7.20)

3B2-3B4

(determined by in situ hybridisation)

(Gaszner et al., 1999)

Experimentally Determined Recombination Data

Location

1-1.5

(FlyBase, 2016)

1-1.4

(Comeron et al., 2012)

1-1.6 +/- 0.6

(Fahmy and Fahmy, 1959)

1-1.4 +/- 0.5

(Fahmy and Fahmy, 1958)

1-1.6

Left of (cM)

crm
l(1)3Bf

(Judd et al., 1972)

Right of (cM)

l(1)3Bd

(Judd et al., 1972)

Notes

Stocks and Reagents

Stocks (17)

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD45751

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000520

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000520

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zolotarev et al., 2016, Gaszner et al., 1999)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

anti-Zw5

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

DNA-protein interactions: genome-wide binding profile assayed for dwg protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

(Filion et al., 2010)

The dwg gene product is a component of the scs chromatin domain boundary and can block enhancer-promoter interactions. Overall orientation not stated: crm? dwg? fs(1)Yb?

(Gaszner et al., 1999)

'l(1)zw5' is synonymous with 'ves' and dwg.

(Judd et al., 1972)

On the basis of phenotype and map position l(1)zw5 mutants are synonymous with vestigium and dwg.

(Shannon et al., 1972)

Most alleles lethal, dying during the first larval instar; the semi-lethal allele, dwg⁷, ceases development from the second instar on, with a few individuals surviving to adulthood. Lethal alleles (dwg⁴, dwg⁵, dwg⁶, and dwg⁸) can be recovered as males in combination with variegating duplications, Dp(1;3)N^264-58, Dp(1;3)w^m49a and Dp(1;4)w^m65g; have rough reduced dark eyes, sparse vibrissae, often missing orbital, ocellar, and vertical bristles, thickened wing veins and incised inner wing margins; such males with a Y are fertile; X0 males are not recovered at 25^oC. Of these alleles only dwg⁷ survives as X0 tissue in gynandromorphs; homozygous germ-line clones in females fail to produce eggs (Garcia-Bellido and Robbins, 1983). dwg¹ recorded as having broad, round tipped wings, with occasional marginal incisions and sometimes grossly deformed in shape and venation; extremely fine bristles and small occasionally rough eyes. Surviving males with any allele are sterile.

Relationship to Other Genes

Source for database merge of

Source for merge of: dwg Sbp

(Gaszner et al., 1999)

Source for merge of: dwg EG:95B7.6

(Gatt and Ashburner, 2000.2.3, FlyBase, 1996-)

Additional comments

Source for merge of dwg EG:95B7.6 was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: dwg CG2711

(Deng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (27)

Reported As

Symbol Synonym

CG2711

(Kasinathan et al., 2020, Haelterman et al., 2014, Krystel and Ayyanathan, 2013, Yano et al., 2012, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Ni et al., 2008, Benos, 2000.12.13)

CG2714

(Sugiyama et al., 2007)

DWG

(Filion et al., 2010, van Bemmel et al., 2010)

Dwg

(Tang et al., 2023)

EG:95B7.6

(Benos et al., 2001, Benos, 2000.12.13)

SBP

(Geyer and Clark, 2002, Gerasimova and Corces, 2001, Udvardy, 1999)

Sbp

ZW-5

(Paradi et al., 1983)

ZW5

(Zhimulev et al., 2024, Rennie et al., 2018, Wang et al., 2018, Khoroshko et al., 2016, Comoglio and Paro, 2014, Ho et al., 2014, Schwartz et al., 2012, modENCODE Consortium et al., 2010, Pathak et al., 2007)

Zw-5

(Donze and Kamakaka, 2002, Oki and Kamakaka, 2002)

l(1)3Be

l(1)zw5

(Lin and Wolfner, 1989, Garcia-Bellido and Robbins, 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Lim and Snyder, 1974, Shannon et al., 1972)

ves

(Fahmy and Fahmy, 1958)

zw-5

(Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Liu and Lim, 1975)

zw5

(Chung et al., 2002, Geyer and Clark, 2002, Lespinet et al., 2002, Blanton et al., 2001, Gerasimova and Corces, 2001, Blanton and Schedl, 2000, Blanton et al., 1999, Gaszner, 1999.7.20, Gaszner et al., 1999, Gaszner et al., 1998, Pastink et al., 1990, Goldberg et al., 1989, Lefevre and Watkins, 1986, Schalet, 1986, Robbins, 1983, Thierry-Mieg, 1982, Lefevre, 1981, Judd et al., 1972)

Name Synonyms

Deformed wings

(Yano et al., 2012)

Zeste white 5

(Matzat and Lei, 2014)

Zeste-white 5

(Vogelmann et al., 2011)

deformed wing

(Chung et al., 2002)

deformed wings

(Graves et al., 2020, Comoglio and Paro, 2014, Housden et al., 2014, Roy et al., 2007)

scs binding protein

(Geyer and Clark, 2002)

scs-binding protein

(Udvardy, 1999)

vestigium

(Fahmy and Fahmy, 1958)

zeste-white 5

(Petesch and Lis, 2008, Arnosti, 2002, Geyer and Clark, 2002)

zeste-white5

(Chung et al., 2002)

Secondary FlyBase IDs

FBgn0003974
FBgn0024976
FBgn0026052

Datasets (4)

Study focus (4)

Experimental Role

Project

Project Type

Title

transgene_used

FBGSE20313

genome binding

The insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome.

transgene_used

FBGSE22069

genome binding

Protein profiling reveals five principal chromatin types in Drosophila cells.

bait_protein

modENCODE_chromatin_proteins_cells

genome binding

Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_chromatin_proteins_flies

genome binding

Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31265

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W4V9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W4V9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000520

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31265/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000520

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000520

FlyMine - An integrated database for Drosophila genomics

FBgn0000520

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2711

MARRVEL_MODEL - MARRVEL (model organism gene)

31265

Linkouts

BioGRID - A database of protein and genetic interactions.

57796

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000520

DroID - A comprehensive database of gene and protein interactions.

FBgn0000520

DRSC - Results frm RNAi screens

FBgn0000520

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

anti-Zw5

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dwg_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000520

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000520

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2711

Flygut - An atlas of the Drosophila adult midgut

FBgn0000520

MIST (genetic) - An integrated Molecular Interaction Database

31265

MIST (protein-protein) - An integrated Molecular Interaction Database

31265

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (141)

The following external sites may use different assemblies or annotations than FlyBase.

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