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Gene Dmel\dwg

General Information
Symbol	Dmel\dwg	Species	D. melanogaster
Name	deformed wings	Annotation symbol	CG2711
Feature type	protein_coding_gene	FlyBase ID	FBgn0000520
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	zw5, Zw-5, l(1)zw5, SBP, EG:95B7.6
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.6
Cytogenetic map	3B3-3B3	Sequence location	X:2,621,731..2,624,075 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene deformed wings is referred to in FlyBase by the symbol Dmel\dwg (CG2711, FBgn0000520). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; DNA binding; chromatin insulator sequence binding. The biological processes in which it is involved are not known. 52 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult; adult segment; sense organ; region of integument; anterior vertical bristle; external compound sense organ; thoracic segment; anterior orbital bristle; pigment cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, AD-type; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1634748_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dwg. Gene sequence location is X:2621731..2624075.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	dwg: deformed wings Most alleles lethal, dying during the first larval instar; the semilethal allele, dwg7, ceases development from the second instar on, with a few individuals surviving to adulthood. Lethal alleles (dwg4, dwg5, dwg6, and dwg8) can be recovered as males in combination with variegating duplications, Dp(1;3)N264-58, Dp(1;3)wm49a, and Dp(1;4)wm65g; have rough reduced dark eyes, sparse vibrissae, often missing orbital, ocellar, and vertical bristles, thickened wing veins, and incised inner wing margins; such males with a Y are fertile; XO males are not recovered at 25. Of these alleles only dwg7 survives as XO tissue in gynandromorphs; homozygous germ-line clones in females fail to produce eggs (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). dwg1 recorded as having broad, round tipped wings, with occasional marginal incisions and sometimes grossly deformed in shape and venation; extremely fine bristles, and small occasionally rough eyes. Surviving males with any allele are sterile. *ves: vestigium Wings abnormal, vary from small and curved to almost normal with cut-away inner margins. Eyes slightly rough and abnormally shaped. Male infertile; viability about 50% normal. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms DNA binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3B3-3B3   Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3C1-3C1     (Gaszner, 1999.7.20) 3B2-3B4   (determined by in situ hybridisation)   (Gaszner et al., 1999)
Experimentally Determined Recombination Data
Location	1-1.4 +/- 0.5 (Fahmy and Fahmy, 1958) 1-1.6   1-1.6 +/- 0.6 (Fahmy and Fahmy, 1959)
Left of (cM)	crm l(1)3Bf (Judd et al., 1972)
Right of (cM)	l(1)3Bd (Judd et al., 1972)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dwg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dwg-RA FBtr0070487  NM_057990   2002   592
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dwg-PA   FBpp0070465   66.3   592   4.92     NP_477338   AAF45819
Additional Polypeptide Data & Comments
Reported size (kDa)	591 (aa) (Gaszner et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264382   AA736204   AA950298   AE014298 AAF45819   AF170448 AAD50986   AI406185   AI513468   AI515702   AW943802   AY061495 AAL29043   BF493069   BG641085   BI162302   BI162303   BI173270   BI228736   BI229971   BI633376   BI637151   BI639069   BI639897   BI639999   CO325347   EC235332   GH783508   GH796567   GH810420   GH811949   GH847402   GH853131   GH898605   GH901650   GH917493   GH940418
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W4V9 Q9U9D0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with nuclear chromatin inferred from direct assay (Blanton et al., 2003) nucleus inferred from direct assay (Gaszner et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    71.575 Larval Midgut    27.6 Larval Hindgut    38.4 Larval Malpighian Tubules    44.1 Larval Fat Body    23.9 Larval Salivary Gland    75.2 Larval Trachea    74.7 Larval Carcass    51.275 Adult Head    37.9 Adult Eye    42.725 Adult Brain    77.3 Adult Thoracic-Abdominal Ganglion    65.4 Adult Crop    49.5 Adult Midgut    31.4 Adult Hindgut    38.9 Adult Malpighian Tubules    48.1 Adult Fat Body    33.8 Adult Salivary Gland    72.2 Adult Heart    26.5 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    57.6 Adult Ovary    104.8 Adult Testis    10.3 Adult Male Accessory Gland    47.2 Adult Carcass    42.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    37.9   NA  Eye    42.725   NA  Brain    77.3   71.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    65.4   NA  Crop    49.5   27.6  Midgut    31.4   38.4  Hindgut    38.9   44.1  Malpighian Tubules    48.1   23.9  Fat Body    no informative data   75.2  Salivary Gland    72.2   NA  Heart    26.5   74.7  Trachea    NA   NA  VirginFemale Spermatheca    58.1   NA  InseminatedFemale Spermatheca    57.6   NA  Ovary    104.8   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   51.275  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    9 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    4 carcass, larvae L3 wandering    7 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    23 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr    30 embryo 08-10hr    28 embryo 10-12hr    31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr  (30) embryo 08-10hr  (28) embryo 10-12hr  (31) embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr    30 embryo 08-10hr    28 embryo 10-12hr    31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr    30 embryo 08-10hr    28 embryo 10-12hr    31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr    30 embryo 08-10hr    28 embryo 10-12hr    31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr  30 embryo 08-10hr  28 embryo 10-12hr  31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr    30 embryo 08-10hr    28 embryo 10-12hr    31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    23 embryo 04-06hr    24 embryo 06-08hr    30 embryo 08-10hr    28 embryo 10-12hr    31 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    8 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    10 adult female 01day    14 adult female 05day    16 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21  (32) wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS  (29) ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21  32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS  29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    9 embryonic Kc167    8 embryonic S1    13 embryonic S3    10 leg disc CME L1    18 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    32 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    18 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    6 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    8 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD45751 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000520 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2711-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | germline clone dwg7 lethal | larval stage | recessive dwg8 lethal | recessive dwg4 dwg5 dwg6 dwg7 dwg8 dwg9 dwg10 dwg11 dwg12 dwg13 dwg14 dwg15 dwg16 dwg17 dwg18 dwg19 dwg20 dwg21 dwg22 dwg23 dwg24 dwg31 dwgM29 dwgM35 dwgM63 dwgM69 dwgT7 dwgT13 partially lethal - majority die dwg7 partially lethal - majority die | polyphasic dwg6 viable dwg1 viable, with Scer\GAL4pnr-MD237 dwgGD1426 viable | male | reduced dwg2 viable | reduced dwg2 dwg3 Sterility Allele male sterile dwg1 dwg2 dwg3 dwg7 male sterile | recessive dwg2 Other Phenotypes Allele visible dwg1 dwg2 dwg3 dwg7 visible | recessive dwg2 wild-type dwgHsp83.PG Phenotype manifest in Allele anterior orbital bristle dwg7 anterior vertical bristle dwg7 eye dwg2 dwg3 dwg7 macrochaeta dwg1 middle orbital bristle dwg7 ocellar bristle dwg7 pigment cell dwg7 posterior orbital bristle dwg7 posterior vertical bristle dwg7 vibrissae dwg7 wing dwg1 dwg2 dwg3 dwg7 wing vein dwg1 dwg7
Classical Alleles ( 45 )
For All Classical Alleles Show
Allele of dwg Class Mutagen Stocks Known lesion dwg8 X ray 2 Yes dwg11-32 spontaneous 1 -- dwg10 ethyl methanesulfonate 0 -- dwg11 ethyl methanesulfonate 0 -- dwg12 triethylenemelamine 0 -- dwg13 methyl methanesulfonate 0 -- dwg14 methyl methanesulfonate 0 -- dwg15 methyl methanesulfonate 0 -- dwg16 methyl methanesulfonate 0 -- dwg17 methyl methanesulfonate 0 -- dwg18 methyl methanesulfonate 0 -- dwg19 methyl methanesulfonate 0 -- dwg1 p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine 0 -- dwg20 methyl methanesulfonate 0 -- dwg21 methyl methanesulfonate 0 -- dwg22 methyl methanesulfonate 0 -- dwg23 methyl methanesulfonate 0 -- dwg24 methyl methanesulfonate 0 -- dwg25 X ray 0 -- dwg26 X ray 0 -- dwg27 X ray 0 -- dwg28 X ray 0 -- dwg29 ethyl methanesulfonate 0 -- dwg2 p-N,N-di-(2-chloroethyl)amino-L-phenylalanine 0 -- dwg30 X ray 0 -- dwg31 spontaneous 0 -- dwg32 spontaneous 0 -- dwg33 spontaneous 0 -- dwg3 p-N,N-di-(2-chloroethyl)amino-L-phenylalanine 0 -- dwg4 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- dwg5 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- dwg6 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- dwg7 X ray 0 -- dwg90 ethyl methanesulfonate 0 Yes dwg9 ethyl methanesulfonate 0 -- dwgM29 methyl methanesulfonate 0 -- dwgM35 methyl methanesulfonate 0 -- dwgM63 methyl methanesulfonate 0 -- dwgM69 methyl methanesulfonate 0 -- dwgNKu1 urethane 0 -- dwgNKx1 X ray 0 -- dwgNKx2 X ray 0 -- dwgNKx3 X ray 0 -- dwgT13 methyl methanesulfonate 0 -- dwgT7 methyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dwg Class Mutagen Stocks Known lesion dwgGD1426 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dwgGLV21031 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dwgJF01580 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dwgKK106406 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dwgHsp83.PG in vitro construct - regulatory fusion 0 -- dwgNIG.2711R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dwgt3.5 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)62d18 (Judd et al., 1972) Df(1)64c4 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)202 (Nomura and Kurokawa, 1997) Df(1)BSC656 (Christensen et al., 2008.12.28) Df(1)BSC710 (Christensen et al., 2008.12.28) Df(1)HM3 (Kramers et al., 1983) Df(1)HM406 (Kramers et al., 1983) Df(1)JC19 (Blanton et al., 2003) Df(1)N-264-58 (Judd et al., 1972) Df(1)TEM1 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM75 (Lim and Snyder, 1974) Df(1)TEM202 (Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM501 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)w258-11 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-42 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-45 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)w258-48 (Kramers et al., 1983, Kramers et al., 1991) Df(1)w12 (Cizeau et al., 1994) Df(1)w-N71a (Judd et al., 1972) Df(1)w-rJ1 (Judd et al., 1972, Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991, Nomura and Kurokawa, 1997) Df(1)w-rJ2 (Judd et al., 1972) Df(1)X12 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)z-deb65 (Goldberg et al., 1989) Df(1)z-deb72 (Goldberg et al., 1989) Df(1)z-deb511 (Goldberg et al., 1989)
Duplicated in	Dp(1;2;Y)w+ (Judd et al., 1972, Kramers et al., 1983, Kramers et al., 1991) Dp(1;2)w+70h (Judd et al., 1972) Dp(1;3)N264-58 (Judd et al., 1972) Dp(1;3)w+67k (Judd et al., 1972) Dp(1;3)wm49a (Judd et al., 1972) Dp(1;4)wm65g (Judd et al., 1972) Dp(1;Y)w+y+ (Ferro, 2002.12) Dp(1;Y)y267g19.1 (Lefevre, 1981)
Not disrupted in	Df(1)7 (Nomura and Kurokawa, 1997) Df(1)62g18 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)64f1 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)64j4 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)65j26 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)304 (Nomura and Kurokawa, 1997) Df(1)K95 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)L126 (Nomura and Kurokawa, 1997) Df(1)N-8 (Kramers et al., 1983, Lin and Wolfner, 1989, Kramers et al., 1991) Df(1)N-54l9 (Kramers et al., 1991) Df(1)N-264-105 (Kramers et al., 1991) Df(1)Pgd-kz (Kramers et al., 1991) Df(1)Sp2F-3A (Schalet, 1986) Df(1)TEM6 (Lim and Snyder, 1974) Df(1)TEM7 (Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM304 (Lim and Snyder, 1974, Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)w55j (Lin and Wolfner, 1989) Df(1)w67k30 (Kramers et al., 1983, Kramers et al., 1991) Df(1)z-deb3 (Goldberg et al., 1989) Df(1)z-deb42 (Goldberg et al., 1989) Df(1)z-deb54 (Goldberg et al., 1989) Df(1)z-deb59 (Goldberg et al., 1989) Df(1)z-deb62 (Goldberg et al., 1989) Df(1)z-deb81 (Goldberg et al., 1989) Df(1)z-deb85 (Goldberg et al., 1989) Df(1)z-deb87 (Goldberg et al., 1989) Df(1)z-deb92 (Goldberg et al., 1989) Df(1)z-deb311 (Goldberg et al., 1989) Df(1)z-deb910 (Goldberg et al., 1989)
Not duplicated in	Dp(1;2)51b (Kramers et al., 1983, Kramers et al., 1991) Dp(1;3)wvco (Schalet, 1986)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{Hsp83-dwg.G} NA UAS construct P{GD1426} NA P{KK106406} NA P{NIG.2711R} NA P{TRiP.GLV21031} NA P{TRiP.JF01580} NA characterization construct P{ttm50+t3.5} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
chromatin insulator sequence binding inferred from direct assay (Blanton et al., 2003, Gaszner et al., 1999) DNA binding inferred from direct assay (Krystel and Ayyanathan, 2013) protein binding inferred from physical interaction with BEAF-32 (Blanton et al., 2003)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
colocalizes_with nuclear chromatin inferred from direct assay (Blanton et al., 2003) nucleus inferred from direct assay (Gaszner et al., 1999)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:U62906 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR012934, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:U62906 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dwg allele Gene References dwg8 BEAF-32 (Blanton et al., 2003) w (Gaszner et al., 1999) dwg90 w (Gaszner et al., 1999) dwgHsp83.PG BEAF-32 (Blanton et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57796 DroID - A comprehensive database of gene and protein interactions. • FBgn0000520 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31265
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65HSH6 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG65HSH6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dwg     Drosophila simulans   Dsim\GD16618 Y   Drosophila sechellia   Dsec\GM26657 Y   Drosophila erecta   Dere\GG18627 Y   Drosophila yakuba   Dyak\GE16280 Y   Drosophila ananassae   Dana\GF22454 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28407 Y   Drosophila persimilis   Dper\GL19918 Y   Drosophila willistoni   Dwil\GK25520 Y   Drosophila virilis   Dvir\GJ18900 Y   Drosophila mojavensis   Dmoj\GI15092 Y   Drosophila grimshawi   Dgri\GH17759 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16618 Drosophila sechellia Dsec\GM26657 Drosophila erecta Dere\GG18627 Drosophila yakuba Dyak\GE16280 Drosophila ananassae Dana\GF22454 Drosophila pseudoobscura pseudoobscura Dpse\GA28407 Drosophila persimilis Dper\GL19918 Drosophila willistoni Dwil\GK25520 Drosophila virilis Dvir\GJ18900 Drosophila mojavensis Dmoj\GI15092 Drosophila grimshawi Dgri\GH17759
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	4094 dwg8/FM7a/Dp(1;2;Y)w+ 31109 y1 v1; P{TRiP.JF01580}attP2 35666 y1 sc* v1; P{TRiP.GLV21031}attP2 7060 dwg11-32/Dp(1;Y)w+y+/C(1)DX, y1 f1
Kyoto	107583 dwg8/FM7a/Dp(1;2;Y)w+
VDRC	v100971 P{KK106406}VIE-260B v4556 w1118; P{GD1426}v4556/TM3
Genomic Clones ( 1 )
	BACR30B01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD45751
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01337 GH26406 HL08164 LD08032 LD28811 LD41347 RE16057 RE26371 RE27876 SD12328 SD19076 SD21515 SD22604 SD22749 SD27448
Other clones	67285 EK196163 RE01660 RP003042747 RP003057645 RP003109378 RP003179296 RP003266734 RP003344196 RP003452024 RP003577184 RP003639554 RP003661626
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000520 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31265
Antibody Information
	polyclonal (Gaszner et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dwg CG2711 (Deng, 1999.11)
Source for database merge of	Source for merge of: dwg EG:95B7.6 (Gatt and Ashburner, 2000.2.3, FlyBase, 1996-) Source for merge of: dwg Sbp (Gaszner et al., 1999)
Additional comments	Source for merge of dwg EG:95B7.6 was sequence comparison (date:000202). (FlyBase, 1996-)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for dwg protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) The dwg gene product is a component of the scs chromatin domain boundary and can block enhancer-promoter interactions. Overall orientation not stated: crm? dwg? fs(1)Yb? (Gaszner et al., 1999) 'l(1)zw5' is synonymous with 'ves' and dwg. (Judd et al., 1972) On the basis of phenotype and map position l(1)zw5 mutants are synonymous with vestigium and dwg. (Shannon et al., 1972) Most alleles lethal, dying during the first larval instar; the semi-lethal allele, dwg7, ceases development from the second instar on, with a few individuals surviving to adulthood. Lethal alleles (dwg4, dwg5, dwg6, and dwg8) can be recovered as males in combination with variegating duplications, Dp(1;3)N264-58, Dp(1;3)wm49a and Dp(1;4)wm65g; have rough reduced dark eyes, sparse vibrissae, often missing orbital, ocellar, and vertical bristles, thickened wing veins and incised inner wing margins; such males with a Y are fertile; X0 males are not recovered at 25oC. Of these alleles only dwg7 survives as X0 tissue in gynandromorphs; homozygous germ-line clones in females fail to produce eggs (Garcia-Bellido and Robbins, 1983). dwg1 recorded as having broad, round tipped wings, with occasional marginal incisions and sometimes grossly deformed in shape and venation; extremely fine bristles and small occasionally rough eyes. Surviving males with any allele are sterile.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057990 RefSeq (Proteins) • NP_477338 DDBJ / EMBL / GenBank • AA264382 AAD50986 AAF45819 AAL29043 AF170448 AI513468 AL021728 AW943802 AY061495 Entrez Gene - A searchable database of RefSeq genes. • 31265 UniProtKB/TrEMBL • Q9U9D0 Q9W4V9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD45751
Linkouts
	BioGRID - A database of protein and genetic interactions • 57796 DroID - A comprehensive database of gene and protein interactions. • FBgn0000520 DRSC - Results from RNAi screens. • FBgn0000520 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000520 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2711-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000520 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31265 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31265 modMine - Data generated by the modENCODE project. • FBgn0000520 REDfly - A database of transcriptional regulatory elements. • FBgn0000520
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	CG2711 (Benos, 2000.12.13, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19, Krystel and Ayyanathan, 2013, Yano et al., 2012) CG2714 (Sugiyama et al., 2007) dwg (Roy et al., 2007, Sugiyama et al., 2007, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Chung et al., 2002, Roy et al., 2011, Japanese National Institute of Genetics, 2012.5.21) DWG (Filion et al., 2010, van Bemmel et al., 2010) EG:95B7.6 (Benos et al., 2001, Benos, 2000.12.13, ) l(1)3Be   l(1)zw5 (Lin and Wolfner, 1989, Paradi et al., 1983, Garcia-Bellido and Robbins, 1983, Thierry-Mieg, 1982, Lim and Snyder, 1974, Shannon et al., 1972, ) SBP (Geyer and Clark, 2002, Gerasimova and Corces, 2001, Udvardy, 1999) Sbp   ves (Fahmy and Fahmy, 1958, ) zw5 (Geyer and Clark, 2002, Lespinet et al., 2002, Gerasimova and Corces, 2001, Blanton et al., 2001, Blanton and Schedl, 2000, Gaszner, 1999.7.20, Gaszner et al., 1999, Blanton et al., 1999, Gaszner et al., 1998, Pastink et al., 1990, Goldberg et al., 1989, Schalet, 1986, Lefevre and Watkins, 1986, Robbins, 1983, Thierry-Mieg, 1982, Lefevre, 1981, Judd et al., 1972, Chung et al., 2002) Zw5 (Chambeyron and Bickmore, 2004, Blanton et al., 2003, West et al., 2002, Bell et al., 2001, Moon et al., 2005, Petesch and Lis, 2008, Kyrchanova et al., 2008, Schoborg and Labrador, 2010) Zw-5 (Oki and Kamakaka, 2002, Donze and Kamakaka, 2002) zw-5 (Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Liu and Lim, 1975) ZW-5 (Paradi et al., 1983) ZW5 (Pathak et al., 2007, modENCODE Consortium et al., 2010)
Name Synonym	deformed wing (Chung et al., 2002) deformed wings (Roy et al., 2007) Deformed wings (Yano et al., 2012) scs binding protein (Geyer and Clark, 2002) scs-binding protein (Udvardy, 1999) vestigium (Fahmy and Fahmy, 1958) zeste-white 5 (Arnosti, 2002, Geyer and Clark, 2002, Petesch and Lis, 2008) zeste-white5 (Chung et al., 2002)
Secondary FlyBase IDs
	FBgn0003974 FBgn0024976 FBgn0026052
References ( 78 )
Generate a list of	All references relating to this gene ( 78 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 3 ) Review  ( 10 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Krystel and Ayyanathan, 2013, Gene 512(2): 373--382 Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. [FBrf0220103] Schwartz et al., 2012, Genome Res. 22(11): 2188--2198 Nature and function of insulator protein binding sites in the Drosophila genome. [FBrf0219925] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Roy et al., 2011, Mol. Genet. Genomics 285(2): 113--123 Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. [FBrf0212912] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...