Zw5, l(1)zw5, zw-5, zeste-white 5, SBP
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dwg using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\dwg in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: dwg CG2711
Source for merge of dwg EG:95B7.6 was sequence comparison ( date:000202 ).
DNA-protein interactions: genome-wide binding profile assayed for dwg protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
On the basis of phenotype and map position l(1)zw5 mutants are synonymous with vestigium and dwg.
Most alleles lethal, dying during the first larval instar; the semi-lethal allele, dwg7, ceases development from the second instar on, with a few individuals surviving to adulthood. Lethal alleles (dwg4, dwg5, dwg6, and dwg8) can be recovered as males in combination with variegating duplications, Dp(1;3)N264-58, Dp(1;3)wm49a and Dp(1;4)wm65g; have rough reduced dark eyes, sparse vibrissae, often missing orbital, ocellar, and vertical bristles, thickened wing veins and incised inner wing margins; such males with a Y are fertile; X0 males are not recovered at 25oC. Of these alleles only dwg7 survives as X0 tissue in gynandromorphs; homozygous germ-line clones in females fail to produce eggs (Garcia-Bellido and Robbins, 1983). dwg1 recorded as having broad, round tipped wings, with occasional marginal incisions and sometimes grossly deformed in shape and venation; extremely fine bristles and small occasionally rough eyes. Surviving males with any allele are sterile.