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Gene Dmel\dx

General Information
Symbol	Dmel\dx	Species	D. melanogaster
Name	deltex	Annotation symbol	CG3929
Feature type	protein_coding_gene	FlyBase ID	FBgn0000524
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-17.0
Cytogenetic map	6B1-6B2	Sequence location	X:6,428,043..6,432,615 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene deltex is referred to in FlyBase by the symbol Dmel\dx (CG3929, FBgn0000524). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; Notch signaling pathway; positive regulation of Notch signaling pathway; Wnt receptor signaling pathway. 34 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; sensillum; adult mesothoracic segment; eo support cell; external compound sense organ; integumentary plate; peripheral nervous system; acrostichal bristle; nervous system; tormogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: WWE domain; WWE domain, subgroup; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626617_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dx. Gene sequence location is X:6428043..6432615.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	dx: deltex Veins show thickenings and terminal deltas; resembles Dl in third chromosomes except fully viable, fertile, and easily classified. Nearly suppressed by su(dx), Su(dx), and Su(dx)2. RK2. dxst: deltex-sterile Veins heavy, confluent, and dilated at junctions; strong deltas at tips. Wings spread wide; margins and tips snipped and nicked. Ocelli sometimes fused with disturbance of hairs and bristles in the region. Acrostichals irregular. Male sterile. Less abnormal phenotype and fertile with Su(dx). RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Ying et al., 2011, PLoS ONE 6(9): e23863
FB2012_01	References Muñoz-Descalzo et al., 2010, Fly 4(3): 182--193 Sequence features BKN27316 HFA18767
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6B1-6B2   Limits computationally determined from genome sequence between P{EP}EP1402&P{EP}CG15893EP1634 and P{EP}Ctr1AEP1364&P{EP}EP1445
Experimentally Determined Cytological Location
Cytogenetic map Notes References 6A-6A   (determined by in situ hybridisation)   (Busseau, 1990) 6A-6A   (determined by in situ hybridisation)   (Busseau et al., 1994)
Experimentally Determined Recombination Data
Location	1-17.0
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dx for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dx-RA FBtr0070914  NM_078509   3824   738
Additional Transcript Data & Comments
Reported size (kB)	4 (northern blot) (Busseau et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dx-PA   FBpp0070876   82.2   738   9.28     NP_511064   AAF46170
Additional Polypeptide Data & Comments
Reported size (kDa)	737 (aa); 80 (kD observed) (Busseau et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WWE domain, subgroup (IPR018123) Zinc finger, RING-type (IPR001841) WWE domain (IPR004170) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696653   AE014298 AAF46170   AI544306   AY863438   AY863439   AY863440   AY863441   AY863442   AY863443   AY863444   AY863445   AY863446   AY863447   AY863448   AY863449   AY863450   AY863451   AY863452   AY863453   AY863454   AY863455   AY863456   AY863457   AY863458   AY863459   AY863460   AY863461   BI172374   BI216085   BI216582   BI227869   BI238103   BI372398   BI486615   BI574249   BI587329   BI604275   BI608182   BI611877   BI612837   BI613151   BI616230   BI620507   BI622527   BT003476 AAO39479   BT033059   CO190676   CO266584   CO279472   CO283219   CO302022   CO313223   CO313387   CO317934   CO319657   CO321440   CO322906   CO325639   CO338947   DN154059   EC058034   EC058201   EC082794   EC084495   EC089626   EC210827   EC223242   EC227675   EC243135   EC246438   EC246905   EC248481   EC250357   EC259965   U09789 AAA18501
UniProtKB/Swiss-Prot	Q23985
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Busseau et al., 1994) embryonic stage -- pupal stage     (Busseau et al., 1994) adult stage | female     (Busseau et al., 1994)
Additional Descriptive Data
	dx transcripts are most abundant in adult females and during the first half of embryogenesis and accumulate at lower levels in larval and pupal stages. (Busseau et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term	cytoplasm (Busseau et al., 1994)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000524    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000524 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000524 expression level Developmental Stage   Expression Level embryo 00-02hr    6586 embryo 02-04hr    2121 embryo 04-06hr    1878 embryo 06-08hr    2948 embryo 08-10hr    2880 embryo 10-12hr    2439 embryo 12-14hr    1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new    1429 white prepupae 12hr    1559 white prepupae 24hr    2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day    1972 adult female 05day    3328 adult female 30day    3414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6586) embryo 02-04hr  (2121) embryo 04-06hr  (1878) embryo 06-08hr  (2948) embryo 08-10hr  (2880) embryo 10-12hr  (2439) embryo 12-14hr  (1658) embryo 14-16hr  (1082) embryo 16-18hr  (712) embryo 18-20hr  (504) embryo 20-22hr  (271) embryo 22-24hr  (281) larva L1  (354) larva L2  (337) larva L3 12hr old  (325) larva L3 puffstage 1-2  (492) larva L3 puffstage 3-6  (980) larva L3 puffstage 7-9  (1236) white prepupae new  (1429) white prepupae 12hr  (1559) white prepupae 24hr  (2139) pupae 2d postWPP  (1075) pupae 3d postWPP  (411) pupae 4d postWPP  (401) adult male 01day  (337) adult male 05day  (374) adult male 30day  (399) adult female 01day  (1972) adult female 05day  (3328) adult female 30day  (3414) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6586) embryo 02-04hr  (2121) embryo 04-06hr  (1878) embryo 06-08hr  (2948) embryo 08-10hr  (2880) embryo 10-12hr  (2439) embryo 12-14hr  (1658) embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new  1429 white prepupae 12hr  (1559) white prepupae 24hr  (2139) pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day  (1972) adult female 05day  (3328) adult female 30day  (3414) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6586 embryo 02-04hr    2121 embryo 04-06hr    1878 embryo 06-08hr    2948 embryo 08-10hr    2880 embryo 10-12hr    2439 embryo 12-14hr    1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new    1429 white prepupae 12hr    1559 white prepupae 24hr    2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day    1972 adult female 05day    3328 adult female 30day    3414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6586 embryo 02-04hr    2121 embryo 04-06hr    1878 embryo 06-08hr    2948 embryo 08-10hr    2880 embryo 10-12hr    2439 embryo 12-14hr    1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new    1429 white prepupae 12hr    1559 white prepupae 24hr    2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day    1972 adult female 05day    3328 adult female 30day    3414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000524 expression level Developmental Stage   Expression Level embryo 00-02hr    6586 embryo 02-04hr    2121 embryo 04-06hr    1878 embryo 06-08hr    2948 embryo 08-10hr    2880 embryo 10-12hr    2439 embryo 12-14hr    1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new    1429 white prepupae 12hr    1559 white prepupae 24hr    2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day    1972 adult female 05day    3328 adult female 30day    3414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6586) embryo 02-04hr  (2121) embryo 04-06hr  (1878) embryo 06-08hr  (2948) embryo 08-10hr  (2880) embryo 10-12hr  (2439) embryo 12-14hr  (1658) embryo 14-16hr  (1082) embryo 16-18hr  (712) embryo 18-20hr  (504) embryo 20-22hr  (271) embryo 22-24hr  (281) larva L1  (354) larva L2  (337) larva L3 12hr old  (325) larva L3 puffstage 1-2  (492) larva L3 puffstage 3-6  (980) larva L3 puffstage 7-9  (1236) white prepupae new  (1429) white prepupae 12hr  (1559) white prepupae 24hr  (2139) pupae 2d postWPP  (1075) pupae 3d postWPP  (411) pupae 4d postWPP  (401) adult male 01day  (337) adult male 05day  (374) adult male 30day  (399) adult female 01day  (1972) adult female 05day  (3328) adult female 30day  (3414) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6586) embryo 02-04hr  2121 embryo 04-06hr  1878 embryo 06-08hr  (2948) embryo 08-10hr  (2880) embryo 10-12hr  2439 embryo 12-14hr  1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new  1429 white prepupae 12hr  1559 white prepupae 24hr  2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day  1972 adult female 05day  (3328) adult female 30day  (3414) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6586 embryo 02-04hr    2121 embryo 04-06hr    1878 embryo 06-08hr    2948 embryo 08-10hr    2880 embryo 10-12hr    2439 embryo 12-14hr    1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new    1429 white prepupae 12hr    1559 white prepupae 24hr    2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day    1972 adult female 05day    3328 adult female 30day    3414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6586 embryo 02-04hr    2121 embryo 04-06hr    1878 embryo 06-08hr    2948 embryo 08-10hr    2880 embryo 10-12hr    2439 embryo 12-14hr    1658 embryo 14-16hr    1082 embryo 16-18hr    712 embryo 18-20hr    504 embryo 20-22hr    271 embryo 22-24hr    281 larva L1    354 larva L2    337 larva L3 12hr old    325 larva L3 puffstage 1-2    492 larva L3 puffstage 3-6    980 larva L3 puffstage 7-9    1236 white prepupae new    1429 white prepupae 12hr    1559 white prepupae 24hr    2139 pupae 2d postWPP    1075 pupae 3d postWPP    411 pupae 4d postWPP    401 adult male 01day    337 adult male 05day    374 adult male 30day    399 adult female 01day    1972 adult female 05day    3328 adult female 30day    3414 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000524    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000524 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval/adult salivary gland, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000524 expression level Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary    571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary  (571.8) Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary    571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary    571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000524 expression level Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary    571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary  571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary    571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    175.425 Larval Midgut    75.3 Larval Hindgut    111.2 Larval Malpighian Tubules    95.1 Larval Fat Body    97.3 Larval Salivary Gland    346.5 Larval Trachea    152.725 Larval Carcass    115 Adult Head    58.9 Adult Eye    70.975 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    47.5 Adult Crop    98.1 Adult Midgut    53 Adult Hindgut    75 Adult Malpighian Tubules    97.4 Adult Fat Body    67.9 Adult Salivary Gland    200.2 Adult Heart    44.325 Adult VirginFemale Spermatheca    99.9 Adult InseminatedFemale Spermatheca    98.6 Adult Ovary    571.8 Adult Testis    17.7 Adult Male Accessory Gland    140.3 Adult Carcass    57.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    58.9   NA  Eye    70.975   NA  Brain    43.2   175.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    47.5   NA  Crop    98.1   75.3  Midgut    53   111.2  Hindgut    75   95.1  Malpighian Tubules    97.4   97.3  Fat Body    67.9   346.5  Salivary Gland    200.2   NA  Heart    44.325   152.725  Trachea    NA   NA  VirginFemale Spermatheca    99.9   NA  InseminatedFemale Spermatheca    98.6   NA  Ovary    571.8   NA  Testis    17.7   NA  Male Accessory Gland    140.3   115  Carcass    57.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000524 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3929-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect | recessive dxENU lethal | pupal stage, with Scer\GAL4ap-md544 dxScer\UAS.cMa semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 dxGD1427 viable dx24 dxeAN1 Sterility Allele male sterile dxst Other Phenotypes Allele flightless | recessive dx1 dxENU dxS1M flightless | recessive | heat sensitive dx1 increased cell number | somatic clone, with Scer\GAL4αTub84B.PP dxScer\UAS.cMa visible dx1-303.hs dx1 dx24 dx152 dxENU dxhs.PB dxP dxS1M dxst visible, with Scer\GAL4pnr-MD237 dxScer\UAS.cMa visible, with Scer\GAL4ptc-559.1 dxScer\UAS.cMa visible | dominant dxD visible | recessive dx1 dx24 dxeAN1 dxENU dxP dxS1M dxunspecified Phenotype manifest in Allele acrostichal bristle dxst anterior crossvein, with Scer\GAL4ptc-559.1 dxScer\UAS.cMa eo neuron dxhs.PB eye dx1 dxENU dxP dxS1M macrochaeta dxhs.PB microchaeta dxENU dxP microchaeta & mesothoracic tergum, with Scer\GAL4pnr-MD237 dxScer\UAS.cMa ocellar bristle dxst ocellus dx1 dxENU dxP dxS1M dxst ommatidium dx1-303.hs dxeAN1 dxhs.PB sensory mother cell | ectopic, with Scer\GAL4ptc-559.1 dxScer\UAS.cMa dxmRZF.Scer\UAS.T:Sjap\GST socket dxhs.PB socket | ectopic dxhs.PB thecogen cell | ectopic dxhs.PB thorax & macrochaeta dx1-303.hs dxhs.PB tormogen cell | ectopic dxhs.PB trichogen cell dxhs.PB wing dx1 dx24 dxENU dxP dxS1M dxTX0 dxeAN1 dxst dx152 wing | distal dx24 wing | distal, with Scer\GAL4ptc-559.1 dxΔPRM.Scer\UAS wing disc | ventral, with Scer\GAL4ptc-559.1 dxScer\UAS.cMa wing margin dxS1M wing margin, with Scer\GAL4ptc-559.1 dxΔPRM.Scer\UAS wing margin | ectopic, with Scer\GAL4ptc-559.1 dxScer\UAS.cMa dxmRZF.Scer\UAS.T:Sjap\GST wing margin bristle, with Scer\GAL4C-96 dxScer\UAS.T:Zzzz\FLAG wing margin bristle | ectopic, with Scer\GAL4ptc-559.1 dxScer\UAS.cMa wing vein dx1 dx24 dxENU dxS1M dxeAN1 dxhs.PB dxst dxunspecified dx152 wing vein, with Scer\GAL4Bx-MS1096 dxGD1427
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of dx Class Mutagen Stocks Known lesion dx1 loss of function allele spontaneous 4 -- dxst spontaneous 2 -- dx152 0 -- dx24 loss of function allele 0 Yes dxD loss of function allele 0 -- dxeAN1 loss of function allele ethyl methanesulfonate 0 -- dxENU ethyl nitrosourea 0 -- dxfl natural population 0 -- dxP P-element activity 0 Yes dxS1M spontaneous 0 -- dxunspecified 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dx Class Mutagen Stocks Known lesion dxGD1427 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dxGLV21042 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dxJF02367 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dxKK107316 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dx1-303.hs in vitro construct 0 Yes dxGMR.PH in vitro construct - regulatory fusion 0 Yes dxhs.PB in vitro construct - regulatory fusion 0 Yes dxmRZF.Scer\UAS.T:Sjap\GST in vitro construct - coding region fusion 0 Yes dxmRZF.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes dxMtnA.PD in vitro construct - regulatory fusion 0 Yes dxScer\UAS.cMa in vitro construct - regulatory fusion 0 -- dxScer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dxScer\UAS.T:Sjap\GST in vitro construct - coding region fusion 0 Yes dxScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dxsev.PM in vitro construct - regulatory fusion 0 Yes dxTX0 in vitro construct - genomic fragment 0 Yes dxΔNBS.mRZF.Scer\UAS.T:Sjap\GST in vitro construct - coding region fusion 0 Yes dxΔNBS.mRZF.Scer\UAS in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes dxΔNBS.Scer\UAS.T:Sjap\GST in vitro construct - coding region fusion 0 Yes dxΔNBS.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dxΔNBS.ΔPRM.Scer\UAS in vitro construct - deletion 0 Yes dxΔPRM.Scer\UAS.T:Sjap\GST in vitro construct - coding region fusion 0 Yes dxΔPRM.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;1)105 (Dobzhansky, 1932) Dp(1;3)DC158 (Popodi et al., 2010-) Dp(1;Y)dx+1 (Florence, 1999.7.22) Dp(1;Y)dx+2 (Florence, 1999.7.22) Dp(1;Y)dx+3 (Florence, 1999.7.22) Dp(1;Y)dx+4 (Florence, 1999.7.22) Dp(1;Y)dx+5 (Florence, 1999.7.22) Dp(1;Y)dx+6 (Florence, 1999.7.22) Dp(1;Y)dx+7 (Florence, 1999.7.22) Dp(1;Y)dx+8 (Florence, 1999.7.22) Ts(1Lt;YLt)J104 (Busseau et al., 1994)
Not duplicated in	Dp(1;1)100 (Dobzhansky, 1932) Dp(1;1)112 (Dobzhansky, 1932) Dp(1;f)102 (Dobzhansky, 1932) Dp(1;f)106 (Dobzhansky, 1932) Dp(1;f)107 (Dobzhansky, 1932) Dp(1;f)118 (Dobzhansky, 1932) Dp(1;f)136 (Dobzhansky, 1932) Dp(1;f)137 (Dobzhansky, 1932) Dp(1;f)q2
Disrupted in	Df(1)dx81 (Florence, 1999.7.22)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1427} NA P{KK107316} NA P{TRiP.GLV21042} NA P{TRiP.JF02367} NA P{UAS-dx.FLAG} NA P{UAS-dx.GST} NA P{UAS-dx.mRZF.GST} NA P{UAS-dx.mRZF} NA P{UAS-dx.ΔNBS.GST} NA P{UAS-dx.ΔNBS.mRZF.GST} NA P{UAS-dx.ΔNBS.mRZF} NA P{UAS-dx.ΔNBS.ΔPRM} NA P{UAS-dx.ΔNBS} NA P{UAS-dx.ΔPRM.GST} NA P{UAS-dx.ΔPRM} NA P{UAS-DxA89} NA heat-shock construct P{Hsp70-dx1-303} NA P{Hsp70-dx} NA characterization construct P{GMR-dx.H} NA P{sev-dx.M} NA P{TX0} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}dxP NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with N (assigned by UniProtKB) (Matsuno et al., 2002)
Biological Process
CV term Evidence References
negative regulation of Notch signaling pathway inferred from direct assay (Matsuno et al., 1995) inferred from direct assay (assigned by UniProtKB) (Matsuno et al., 2002) Notch signaling pathway inferred from genetic interaction with N (Gorman and Girton, 1992) inferred from physical interaction with N (Diederich et al., 1994) positive regulation of Notch signaling pathway inferred from direct assay (Matsuno et al., 1995) inferred from direct assay (assigned by UniProtKB) (Matsuno et al., 2002) Wnt receptor signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Ramain et al., 2001)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Fortini and Artavanis-Tsakonas, 1994) inferred from direct assay (assigned by UniProtKB) (Busseau et al., 1994)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
Notch binding traceable author statement (Martinez Arias, 2002) zinc ion binding inferred from electronic annotation with InterPro:IPR001841, InterPro:IPR018123 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
Notch signaling pathway traceable author statement (Martinez Arias, 2002) positive regulation of Notch signaling pathway traceable author statement (Kadesch, 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dx allele Gene References dx1 CG6194 (Thumm and Kadowaki, 2001) mam (Helms et al., 1999) N (Matsuno et al., 1997) Nle (Royet et al., 1998) Su(dx) (Busseau et al., 1994) dx24 H (Nagel et al., 2000) Hsc70-4 (Hing et al., 1999) M285 (Go and Artavanis-Tsakonas, 1998) dxeAN1 N (Verheyen et al., 1996) dxENU dsh (Ramain et al., 2001) N (Busseau et al., 1994, Ramain et al., 2001) Su(dx) (Busseau et al., 1994, Fostier et al., 1998) dxP N (Ramain et al., 2001) Su(dx) (Busseau et al., 1994) dxS1M M285 (Go and Artavanis-Tsakonas, 1998) N (Hing et al., 1994) Su(dx) (Busseau et al., 1994, Fostier et al., 1998) dxScer\UAS.cMa Su(dx) (Mazaleyrat et al., 2003) dxunspecified E(nd)195 (Hing and Artavanis-Tsakonas, 1995) hrg (Murata et al., 1996) N (Gorman and Girton, 1992) unspecified aya (Suzuki et al., 2000) cp (Hing et al., 1999) Hs3st-B (Kamimura et al., 2004) N (Cornell et al., 1999) rho (Sturtevant and Bier, 1995) Su(dx) (Cornell et al., 1999) Su(H) (Koelzer and Klein, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58076 DroID - A comprehensive database of gene and protein interactions. • FBgn0000524 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31589
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22262 Dere\GG19593 Dgri\GH12685 Dmoj\GI16357 Dper\GL14302 Dpse\GA17782 Dsec\GM12494 Dsim\GD16802 Dvir\GJ16727 Dwil\GK20139 Dyak\GE16754
Curated drosophilid orthologs	Dmau\dx (Moehring et al., 2004) Dpse\GA17782   Dsim\dx (Moehring et al., 2004) Dyak\dx (Takano-Shimizu, 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001459-PA Aedes aegypti (mosquito) AGAP000903-PA Anopheles gambiae (mosquito) XP_001120834.1 Apis mellifera (honey bee) XP_001952875.1 Acyrthosiphon pisum (pea aphid) 124419 Branchiostoma floridae (lancelet) BGIBMGA009826-PA Bombyx mori (silk worm) ENSBTAP00000022253 Bos taurus (bovine) ENSCAFP00000013158 Canis familiaris (dog) Chro.60594 Cryptosporidium hominis (obligate parasite) cgd6_5150 Cryptosporidium parvum (protozoan parasite) CPIJ010182 Culex pipens (mosquito) ENSCPOP00000001484 Cavia porcellus (guinea pig) ENSCSAVP00000010376 Ciona savignyi (sedentary tunicate) 220308 Capitella spl (polychaete worm) ENSECAP00000016143 Equus caballus (horse) ENSGACP00000021558 Gymnopilus aculeatus (mushroom) ENSGALP00000002940 Gallus gallus (chicken) 191022 Hypsipyla robusta (cedar shoot borer) ENSP00000257600 Homo sapiens (human) ISCW003605-PA Ixodes scapularis (deer tick) ENSMODP00000004107 Monodelphis domestica (gray opossum) ENSMMUP00000013449 Macaca mulatta (rhesus monkey) ENSMUSP00000040229 Mus musculus (house mouse) XP_001607641.1 Nasonia vitripennis (wasp) ENSOANP00000001687 Ornithorynchus anatinus (platypus) ENSORLP00000002793 Oryzias latipes (japanese killifish) PHUM002882-PA Pediculus humanus (human body louse) PP04248 Pristionchus pacificus (nematode) 164419 Physcomitrella patens (moss) ENSPPYP00000019578 Pongo pygmaeus (orangutan) ENSPTRP00000009298 Pan troglodytes (chimpanzee) ENSRNOP00000051686 Rattus norvegicus (norway rat) XP_001184641.1 Strongylocentrotus purpuratus (purple sea urchin) XP_973798.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008800 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024578 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000035822 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11879 NV11850 LH18892 ISCW003605 FBgn0234248 FBgn0222136 FBgn0203908 FBgn0188389 FBgn0167431 JGI_V11_301187 FBgn0077791 FBgn0151907 FBgn0139105 FBgn0120164 FBgn0111795 FBgn0099260 CPIJ010182 BGIBMGA009826 ACYPI002157 GB10770 AGAP000903 AAEL001459 PHUM233590 GLEAN_05760
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	34 ec1 dx1 119 su(dx)1 dx1 27041 y1 v1; P{TRiP.JF02367}attP2 664 br3 dxst; ed1 Su(dx)2 35677 y1 sc* v1; P{TRiP.GLV21042}attP2
Kyoto	105691 ec1 dx1 105744 su(dx)1 dx1 106031 br3 dxst; ed1 Su(dx)2
VDRC	v106086 P{KK107316}VIE-260B v7795 w1118; P{GD1427}v7795
Genomic Clones ( 2 )
	BACR12B22 BACR18C18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD03194 RE59350
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM08069 RE14834 RE22895 RE23772 RE25250 RE34483 RE70065 RH12362 RH18318 RH23007 RH27873 RH41821 RH42243 RH46124 RH51667 RH54417 RH69583 SD10810
Other clones	35697 43283 59005 62105 70162 106390 165393 175250.1 181960 214513.3 CK01.60D.H8 CK01.65C.F3 CK01.126A.H8 CK01.132D.B4 EK049046 EK134608 EK146949 EK162624 EK169203 EK182912 EK185705 EK189163 EK197016 EK231925 EK232501 EK269821 EK279854 EP00416
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000524 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31589
Antibody Information
	monoclonal, polyclonal (Busseau et al., 1994)
Other Information
Discoverer
	Bridges, 26th Aug. 1922.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Mutant analysis suggests that dx signalling is dependent on the activity of Su(H). (Koelzer and Klein, 2006) dx protein activates N signaling in a Su(H)-independent manner. dx protein promotes the relocalisation of N protein from the apical plasma membrane to the intracellular vesicles. The accumulation of N protein in the late endosome appears to be required for dx-mediated Su(H)-independent N signaling. (Hori et al., 2004) The dx RING-H2 domain is required for the formation of dx homo-multimer complexes. (Matsuno et al., 2002) Mutations (unspecified) enhance the rough eye phenotype of SerTM.sev.T:VSV\G and DlTM.sev flies. (Sun and Artavanis-Tsakonas, 1996) The dx gene product functions in N signalling as a positive regulator, that acts genetically upstream of N. (Matsuno and Artavanis-Tsakonas, 1995) Mutations can act as dominant modifiers of the activated N eye phenotype (FBrf0064452). (Verheyen et al., 1995) Genetic interaction analysis suggests a three-way interaction between Su(dx), dx and N. (Busseau et al., 1994) dx is involved in the N signalling pathway. (Diederich et al., 1994) Loss of function alleles of Su(H) dominantly suppress wing tip deltas and thick veins phenotype of dx, but gain of function alleles of Su(H) dominantly enhance the phenotype of mutant phenotype of dx causing reduced, vg-like wings. (Fortini and Artavanis-Tsakonas, 1994) Su(H) shows allele specific interactions with N, Dl, dx and mam. (Fortini and Artavanis-Tsakonas, 1994) Mutations at dx share phenotypes with mutations at sno, and genetic interactions indicate that sno, dx and N function in common pathways. (Coyle-Thompson and Banerjee, 1993) dx is involved in cell fate decision processes. The dx gene functions with N in one or more developmental pathways to specify cell fate. (Gorman and Girton, 1992) dx is a suppressor of N and plays an important role in the genetic circuitry within which N, Dl and mam neurogenic loci operate. (Xu and Artavanis-Tsakonas, 1990) dx mutations are associated with a maternal embryo effect. (Xu and Artavanis-Tsakonas, 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078509 RefSeq (Proteins) • NP_511064 DDBJ / EMBL / GenBank • AAA18501 AAF46170 AAO39479 AY863438 AY863439 AY863440 AY863441 AY863442 AY863443 AY863444 AY863445 AY863446 AY863447 AY863448 AY863449 AY863450 AY863451 AY863452 AY863453 AY863454 AY863455 AY863456 AY863457 AY863458 AY863459 AY863460 AY863461 BI372398 BT003476 U09789 Entrez Gene - A searchable database of RefSeq genes. • 31589 UniProtKB/Swiss-Prot • Q23985
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WWE domain, subgroup (IPR018123) Zinc finger, RING-type (IPR001841) WWE domain (IPR004170) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58076 DroID - A comprehensive database of gene and protein interactions. • FBgn0000524 DRSC - Results from RNAi screens. • FBgn0000524 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000524 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3929-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000524 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31589 InParanoid A subset of ortholog calls from InParanoid. • AAEL001459-PA Aedes aegypti (mosquito) AGAP000903-PA Anopheles gambiae (mosquito) XP_001120834.1 Apis mellifera (honey bee) XP_001952875.1 Acyrthosiphon pisum (pea aphid) 124419 Branchiostoma floridae (lancelet) BGIBMGA009826-PA Bombyx mori (silk worm) ENSBTAP00000022253 Bos taurus (bovine) ENSCAFP00000013158 Canis familiaris (dog) Chro.60594 Cryptosporidium hominis (obligate parasite) cgd6_5150 Cryptosporidium parvum (protozoan parasite) CPIJ010182 Culex pipens (mosquito) ENSCPOP00000001484 Cavia porcellus (guinea pig) ENSCSAVP00000010376 Ciona savignyi (sedentary tunicate) 220308 Capitella spl (polychaete worm) ENSECAP00000016143 Equus caballus (horse) ENSGACP00000021558 Gymnopilus aculeatus (mushroom) ENSGALP00000002940 Gallus gallus (chicken) 191022 Hypsipyla robusta (cedar shoot borer) ENSP00000257600 Homo sapiens (human) ISCW003605-PA Ixodes scapularis (deer tick) ENSMODP00000004107 Monodelphis domestica (gray opossum) ENSMMUP00000013449 Macaca mulatta (rhesus monkey) ENSMUSP00000040229 Mus musculus (house mouse) XP_001607641.1 Nasonia vitripennis (wasp) ENSOANP00000001687 Ornithorynchus anatinus (platypus) ENSORLP00000002793 Oryzias latipes (japanese killifish) PHUM002882-PA Pediculus humanus (human body louse) PP04248 Pristionchus pacificus (nematode) 164419 Physcomitrella patens (moss) ENSPPYP00000019578 Pongo pygmaeus (orangutan) ENSPTRP00000009298 Pan troglodytes (chimpanzee) ENSRNOP00000051686 Rattus norvegicus (norway rat) XP_001184641.1 Strongylocentrotus purpuratus (purple sea urchin) XP_973798.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008800 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024578 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000035822 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/deltex.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31589 modMine - Data generated by the modENCODE project. • FBgn0000524 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11879 NV11850 LH18892 ISCW003605 FBgn0234248 FBgn0222136 FBgn0203908 FBgn0188389 FBgn0167431 JGI_V11_301187 FBgn0077791 FBgn0151907 FBgn0139105 FBgn0120164 FBgn0111795 FBgn0099260 CPIJ010182 BGIBMGA009826 ACYPI002157 GB10770 AGAP000903 AAEL001459 PHUM233590 GLEAN_05760
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG3929 (Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Ying et al., 2011) DMDELTEX (Schug et al., 1998) Dx (Hori et al., 2005, Duvic et al., 2002, Fostier et al., 2002, Hori et al., 2002, Anonymous, 2006, Koelzer and Klein, 2006, Nurminsky, 2007, Weinmaster, 1997, Muñoz-Descalzo et al., 2010) dx (Kamimura et al., 2004, Kamimura et al., 2004, Hori et al., 2005, Fuwa et al., 2006, Yamada et al., 2008, Mukherjee et al., 2005, Macdonald and Long, 2005, Kankel et al., 2007, Wilkin et al., 2008, Parks et al., 2008, Bejarano et al., 2008, Ayroles et al., 2009, Hurlbut et al., 2009, Popodi et al., 2010-)
Name Synonym	deltex (Diederich, 1994.5.16, Kamimura et al., 2004, Kamimura et al., 2004, Fuwa et al., 2006, Hurlbut et al., 2009, Moores et al., 2008, Dalton et al., 2011) Deltex (Tipping and Veraksa, 2007, Hung et al., 2007, Anonymous, 2006, Radtke et al., 2005, Giebel and Wodarz, 2006, Yamada et al., 2008, Wilkin et al., 2008, Parks et al., 2008, Weinmaster, 1997, Ying et al., 2011, Muñoz-Descalzo et al., 2010)
Secondary FlyBase IDs
	FBgn0026856
References ( 141 )
Generate a list of	All references relating to this gene ( 141 )
List References by type	Research paper  ( 63 ) Supplementary material  ( 5 ) Review  ( 25 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 35 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 1 ) Computer file  ( 1 ) Book  ( 1 )
Recent research papers ( 3 )
	Dalton et al., 2011, Cell Death Differ. 18(7): 1150--1160 Drosophila Ndfip is a novel regulator of Notch signaling. [FBrf0214123] Ying et al., 2011, PLoS ONE 6(9): e23863 Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster. [FBrf0215242] Muñoz-Descalzo et al., 2010, Fly 4(3): 182--193 Wingless modulates the ligand independent traffic of Notch through Dishevelled. [FBrf0216353] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...