Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
737 (aa); 80 (kD observed)
Homomultimer; the oligomerization is required for its function. Interacts with the ankyrin repeats of Notch.
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dx using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\dx in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dx protein activates N signaling in a Su(H)-independent manner. dx protein promotes the relocalisation of N protein from the apical plasma membrane to the intracellular vesicles. The accumulation of N protein in the late endosome appears to be required for dx-mediated Su(H)-independent N signaling.
Loss of function alleles of Su(H) dominantly suppress wing tip deltas and thick veins phenotype of dx, but gain of function alleles of Su(H) dominantly enhance the phenotype of mutant phenotype of dx causing reduced, vg-like wings.
Bridges, 26th Aug. 1922.