FB2020_06, released Dec 22, 2020

Gene: Dmel\ec

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General Information
Symbol
Dmel\ec
Species
D. melanogaster
Name
echinus
Annotation Symbol
CG2904
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000542
Gene Model Status
Current
Stock Availability
48 publicly available
Gene Snapshot
echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death. [Date last reviewed: 2019-07-11]
Other Summaries
Also Known As

EG:EG0002.3

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:3,811,698..3,857,621 [+]
Recombination map

1-5

RefSeq locus
NC_004354 REGION:3811698..3857621
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein phosphatase 1 binding
inferred from physical interaction with FLYBASE:flw; FB:FBgn0000711
(Bennett et al., 2006)
inferred from physical interaction with FLYBASE:Pp1-13C; FB:FBgn0003132
(Bennett et al., 2006)
inferred from physical interaction with FLYBASE:Pp1α-96A; FB:FBgn0003134
(Bennett et al., 2006)
inferred from physical interaction with FLYBASE:Pp1-87B; FB:FBgn0004103
(Bennett et al., 2006)
NOT enables thiol-dependent ubiquitin-specific protease activity
inferred from direct assay
(Copeland et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Montrasio et al., 2007)
involved_in ommatidial rotation
inferred from mutant phenotype
(Montrasio et al., 2007)
involved_in positive regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Copeland et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein deubiquitination
inferred from electronic annotation with InterPro:IPR001394
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C19 NON-PEPTIDASE HOMOLOGS -
C19 non-peptidase homologs are similar in amino acid sequence to USP deubiquitinases (C19 cysteine peptidases) but lack one or more of the expected catalytic residues. (Adapted from FBrf0239469.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ec: echinus
Eyes large and bulging. Eye surface rough; facets large. Wings rather short and broad. Body thickset. Tends to remove dorsocentrals (posterior more than anterior) and posterior notopleurals; may also add dorsocentrals anterior to anterior dorsocentrals whether or not posterior bristles removed (Sturtevant). Reduces number of mesopleural hairs in h homozygotes (Sturtevant, 1969, Dev. Biol. 21: 48-61). ec is visible in +/ec/ec triploids (Gersh). RK1.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\ec for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.42

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ec-RA
FBtr0070606
NM_166992
6759
1712
ec-RB
FBtr0112801
NM_130722
6863
1746
ec-RC
FBtr0112802
NM_001103407
6681
1765
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ec-PA
FBpp0100019
188.4
1712
8.88
NP_726893
AAF45898
ec-PB
FBpp0111713
192.0
1746
8.98
NP_570078
AAN09109
ec-PC
FBpp0111714
193.4
1765
9.21
NP_001096877
ABW09333
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ec using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
retina
(Copeland et al., 2007)
cone cell
(Copeland et al., 2007)
primary pigment cell
(Copeland et al., 2007)
interommatidial precursor cell
(Copeland et al., 2007)
Additional Descriptive Data

ec transcript is ubiquitously expressed at low uniform levels in the pupal retinal, and is detected in cone cells, primary pigment cells, and interommatidial cells.

(Copeland et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ec in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 30 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ec
Transgenic constructs containing regulatory region of ec
Deletions and Duplications ( 71 )
Disrupted in
Df(1)172
(Patterson, 1932)
Df(1)235
(Patterson, 1932)
Df(1)308
(Patterson, 1932)
Df(1)314
(Mackensen, 1935, Patterson, 1932)
Df(1)cho3
(Steinmann-Zwicky, 1988)
Df(1)cho5
(Steinmann-Zwicky, 1988)
Df(1)cho10
(Steinmann-Zwicky, 1988)
Df(1)cho23
(Steinmann-Zwicky, 1988)
Df(1)GA102
(Montrasio et al., 2007)
Df(1)HC244
(Montrasio et al., 2007, Oliver et al., 1988, Steinmann-Zwicky, 1988, Craymer and Roy, 1980, Lawlor, 1980)
Df(1)HF366
(Oliver et al., 1988, Craymer and Roy, 1980)
Df(1)ovo15
(Steinmann-Zwicky, 1988)
Df(1)rb23
(Steinmann-Zwicky, 1988)
Df(1)rb34
(Steinmann-Zwicky, 1988)
Df(1)rb47
(Oliver et al., 1988)
Df(1)w62g26
(Lefevre, 1970)
Df(1)wm258-44
Df(1)w-ec
(Lefevre and Wilkins, 1966)
Df(2L)ushE6
(Heitzler, 2010.5.12)
T(1;4)231b
(Patterson, 1932)
Tp(1;2)w-ec
(Lefevre and Wilkins, 1966)
Duplicated in
Dp(1;1)105
(Dobzhansky, 1932)
Dp(1;3)DC067
(Popodi et al., 2010-, Venken et al., 2010)
Dp(1;f)102
(Dobzhansky, 1932)
In(1)ClLy4R
Tp(1;3)w+67k
(Lefevre, 1970)
Ts(1Lt;4Lt)4C3
(Hawley et al., 1992)
Not disrupted in
Df(1)7aA
(Mackensen, 1935)
Df(1)247g
(Patterson, 1932)
Df(1)262
(Patterson, 1932)
Df(1)267
(Patterson, 1932)
Df(1)271
(Patterson, 1932)
Df(1)303
(Patterson, 1932)
Df(1)bi-D2
(Oliver et al., 1988)
Df(1)C149
(Oliver et al., 1988)
Df(1)cho19
(Steinmann-Zwicky, 1988)
Df(1)choL1
(Goode et al., 1996)
Df(1)ED6712
(Montrasio et al., 2007)
Df(1)GA56
(Oliver et al., 1988)
Df(1)GA102
(Oliver et al., 1988)
Df(1)JC70
(Oliver et al., 1988, Schalet, 1986)
Df(1)N-8
(Mackensen, 1935)
Df(1)N-54l9
(Mohler, 1956)
Df(1)N73
(Oliver et al., 1988)
Df(1)N-264-58
(Demerec, 1940)
Df(1)N55l
(Hillman, 1958)
Df(1)ovo6
(Oliver et al., 1988)
Df(1)ovo7
(Oliver et al., 1988)
Df(1)rb1
(Oliver et al., 1988)
Df(1)rb13
(Oliver et al., 1988)
Df(1)rb30
(Oliver et al., 1988)
Df(1)rb33
(Oliver et al., 1988)
Df(1)rb46
(Oliver et al., 1988)
Df(1)RC40
(Oliver et al., 1988, Craymer and Roy, 1980)
Df(1)Sp(rb)
(Schalet, 1986)
In(1)ClLbbDfR
T(1;3)N34b
(Oliver, 1937)
Not duplicated in
Dp(1;1)100
(Dobzhansky, 1932)
Dp(1;1)112
(Dobzhansky, 1932)
Dp(1;2)w-ec
(Schalet, 1986, Lefevre, 1968)
Dp(1;3)sn13a1
(Schalet, 1986)
Dp(1;3)w+67k
Dp(1;f)106
(Dobzhansky, 1932)
Dp(1;f)107
(Dobzhansky, 1932)
Dp(1;f)118
(Dobzhansky, 1932)
Dp(1;f)136
(Dobzhansky, 1932)
In(1)bbDfLClR
Ts(1Lt;4Lt)N264-12
(Hawley et al., 1992)
Ts(1Lt;4Lt)wm5
(Hawley et al., 1992)
Ts(1Lt;4Lt)wm258-18
(Hawley et al., 1992)
Ts(1Lt;4Lt)wm258-21
(Hawley et al., 1992)
Partially disrupted in
Df(1)ecΔ9
(Copeland et al., 2007)
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of pupal stage, with Scer\GAL4dpp.PU
partially lethal, with Scer\GAL4elav.PU
partially lethal, with Scer\GAL4sqh.PW
viable
Other Phenotypes
Allele
decreased cell death | pupal stage P6
decreased cell death | pupal stage P7
pain response defective | third instar larval stage, with Scer\GAL4ppk.1.9
sensory perception defective | third instar larval stage, with Scer\GAL4ppk.1.9
short lived, with Scer\GAL4elav.PU
short lived, with Scer\GAL4sqh.PW
some die during pupal stage, with Scer\GAL4dpp.PU
visible
visible (with Df(1)HC244)
visible | recessive
wild-type
Phenotype manifest in
Allele
adult abdomen
adult thorax
cone cell
dorsocentral bristle
eye
eye (with Df(1)HC244)
interommatidial precursor cell | pupal stage P6 | supernumerary
interommatidial precursor cell | pupal stage P7 | supernumerary
ommatidium
ommatidium (with Df(1)GA102)
ommatidium (with Df(1)HC244)
ommatidium (with ec1)
ommatidium (with ecKG09175)
ommatidium (with ecKG10228)
ommatidium (with ecspok)
ommatidium | pupal stage P6
ommatidium | pupal stage P7
posterior notopleural bristle
primary pigment cell
primary pigment cell precursor | pupal stage P6 | supernumerary
retina | pupal stage
wing
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\USP54
6 of 15
Yes
Yes
1  
Hsap\USP53
4 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Usp53
6 of 15
Yes
Yes
Mmus\Usp54
6 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Usp54
5 of 13
Yes
Yes
Rnor\Usp53
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\usp53
3 of 12
Yes
Yes
Xtro\usp54
3 of 12
Yes
Yes
Danio rerio (Zebrafish) (4)
Drer\usp54a
7 of 15
Yes
Yes
Drer\usp53b
4 of 15
No
Yes
Drer\usp54b
4 of 15
No
Yes
Drer\LOC101885715
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (14)
Atha\AT3G47890
3 of 9
Yes
Yes
Atha\AT3G47910
2 of 9
No
Yes
Atha\AT1G52430
1 of 9
No
Yes
Atha\AT1G52450
1 of 9
No
Yes
Atha\AT1G65110
1 of 9
No
Yes
Atha\AT1G65120
1 of 9
No
Yes
Atha\AT2G27630
1 of 9
No
Yes
Atha\AT2G27650
1 of 9
No
Yes
Atha\AT2G34230
1 of 9
No
Yes
Atha\AT2G34240
1 of 9
No
Yes
Atha\AT5G51530
1 of 9
No
Yes
Atha\AT5G61940
1 of 9
No
Yes
Atha\AT5G61950
1 of 9
No
Yes
Atha\MEE20
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900ZY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006113
Drosophila simulans
Dsim\GD16657
Drosophila sechellia
Dsec\GM12311
Drosophila erecta
Dere\GG18676
Drosophila yakuba
Dyak\GE16315
Drosophila ananassae
Dana\GF22096
Drosophila pseudoobscura pseudoobscura
Dpse\GA22668
Drosophila willistoni
Dwil\GK10224
Drosophila virilis
Dvir\GJ15954
Drosophila mojavensis
Dmoj\GI16477
Drosophila grimshawi
Dgri\GH17608
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500MJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010886
Glossina morsitans
Tsetse fly
Gmor\GMOY001492
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10198
Mayetiola destructor
Hessian fly
Mdes\Mdes003191
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002171
Anopheles gambiae
Malaria mosquito
Agam\AGAP000205
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005165
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00HE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002483
Danaus plexippus
Monarch butterfly
Dple\DPOGS208912-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014666
Apis florea
Little honeybee
Aflo\3285243140
Apis mellifera
Western honey bee
Amel\GB43798
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11624
Bombus terrestris
Buff-tailed bumblebee
Bter\15216211
Linepithema humile
Argentine ant
Lhum\LH14852
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0015f1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013541
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02607
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04690
Tribolium castaneum
Red flour beetle
Tcas\TC011087
Pediculus humanus
Human body louse
Phum\PHUM222100
Cimex lectularius
Bed bug
Clec\CLEC001569
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002866
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11304
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00GF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004631
Ixodes scapularis
Black-legged tick
Isca\ISCW007716
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69586.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66137.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69585.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66136.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g09820
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309463
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00Q6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_280
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000269
Gallus gallus
Domestic chicken
Ggal\USP54
Gallus gallus
Domestic chicken
Ggal\USP53
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    USP54; ubiquitin specific peptidase 54
    6 of 15
         
        USP53; ubiquitin specific peptidase 53
        4 of 15
        617431
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            ec - Pp1-13C
            two hybrid
            (Bennett et al., 2006)
            ec - Pp1-87B
            two hybrid
            (Bennett et al., 2006)
            ec - Pp1α-96A
            two hybrid
            (Bennett et al., 2006)
            ec - flw
            two hybrid
            (Bennett et al., 2006)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            ec
            suppressible
            bsk
            (Montrasio et al., 2007)
            ec
            suppressible
            nmo
            (Montrasio et al., 2007)
            ec
            suppressible
            S
            (Montrasio et al., 2007)
            ec
            suppressible
            shg
            (Montrasio et al., 2007)
            ec
            suppressible
            spi
            (Montrasio et al., 2007)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            X
            Recombination map

            1-5

            Cytogenetic map
            3F2-3F3
            Sequence location
            X:3,811,698..3,857,621 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            3F2-3F3
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            1-5

            (FlyBase, 2016)

            1-4.6

            (Comeron et al., 2012)

            1-5.5

            (Lawlor, 1980, Fraser, 1942)
            Left of (cM)
            Right of (cM)
            (Salz and Kiger, 1984)
            Notes
            Stocks and Reagents
            Stocks (48)
            Genomic Clones (27)
            cDNA Clones (53)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: ec CG2904

            (FlyBase, 1996-)
            Additional comments

            Source for merge of ec CG2904 was sequence comparison ( date:040503 ).

            (FlyBase, 1996-)
            Other Comments

            rst expression and sorting of interommatidial cells are not affected by ec mutations.

            (Reiter et al., 1996)

            Individuals homozygous for Bpt1 and ec exhibit no Bpt1 phenotype. A low frequency of individuals exhibit the lethal pharate adult phenotype.

            (Duus et al., 1992)

            A screen for rough eye mutants identifies ec, ec is required for normal elimination of surplus cells from the retinal epithelium. Cell death eliminates 2 or 3 cells per ommatidium 35 and 50 hours after pupation.

            (Wolff and Ready, 1991)
            Origin and Etymology
            Discoverer

            Bridges, 6th Dec. 1915.

            Etymology
            Identification
            External Crossreferences and Linkouts ( 46 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (6)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
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            References (104)