FB2020_01, released Feb 12, 2020

Gene: Dmel\EcR

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General Information
Symbol
Dmel\EcR
Species
D. melanogaster
Name
Ecdysone receptor
Annotation Symbol
CG1765
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000546
Gene Model Status
Current
Stock Availability
81 publicly available
Gene Snapshot
Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

EcR-B1, EcRB1, DmEcR, EcR-A, ecdysteroid receptor

Key Links
Genomic Location
Cytogenetic map
42A9-42A12
Sequence location
2R:6,087,873..6,169,087 [-]
Recombination map

2-55

RefSeq locus
NT_033778 REGION:6087873..6169087
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the nuclear hormone receptor family. NR1 subfamily. (P34021)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
DNA binding; contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; ecdysone binding; contributes_to nuclear receptor activity; protein binding; protein heterodimerization activity; repressing transcription factor binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription coactivator binding; transcription regulatory region sequence-specific DNA binding
Predictions / Assertions
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; ligand-activated transcription factor activity; nuclear receptor activity; nuclear receptor transcription coactivator activity; RNA polymerase II regulatory region sequence-specific DNA binding; signaling receptor activity; steroid binding; steroid hormone receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Summaries
Gene Group (FlyBase)
NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -
Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).
Protein Function (UniProtKB)
Receptor for ecdysone (PubMed:1913820, PubMed:30293839). Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839).
(UniProt, P34021)
Summary (Interactive Fly)

transcription factor - nuclear receptor - zinc finger - regulates molting cycles and oogenesis

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\EcR or the JBrowse view of Dmel\EcR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
EcR-RA
FBtr0086008
NM_165461
5108
849
EcR-RB
FBtr0086011
NM_165465
4092
878
EcR-RC
FBtr0086012
NM_165464
4984
669
EcR-RD
FBtr0086009
NM_165462
3740
849
EcR-RE
FBtr0086010
NM_165463
5233
849
EcR-RG
FBtr0302439
NM_001169590
8415
878
Additional Transcript Data and Comments
Reported size (kB)

6, 5, 4 (northern blot)

(Talbot et al., 1993)

6.0 (northern blot)

(Koelle et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
EcR-PA
FBpp0085349
91.2
849
7.71
NP_724456
AAF57278
EcR-PB
FBpp0085352
93.9
878
6.88
NP_724460
AAF57280
EcR-PC
FBpp0085353
73.3
669
6.76
NP_724459
AAM68347
EcR-PD
FBpp0085350
91.2
849
7.71
NP_724457
AAG22334
EcR-PE
FBpp0085351
91.2
849
7.71
NP_724458
AAM68346
EcR-PG
FBpp0291631
93.9
878
6.88
NP_001163061
ACZ94341
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

849 aa isoforms: EcR-PA, EcR-PD, EcR-PE
878 aa isoforms: EcR-PB, EcR-PG
Additional Polypeptide Data and Comments
Reported size (kDa)

878, 849, 669 (aa); 105, 80 (kD)

(Talbot et al., 1993)

878 (aa); 105 (kD observed)

(Koelle et al., 1991)
Comments

alternatively spliced exon

(FlyBase, 1992-)
External Data
Subunit Structure (UniProtKB)

Heterodimer of USP and ECR (PubMed:8247157). Only the heterodimer is capable of high-affinity binding to ecdysone (PubMed:8247157). Interacts with trr in an ecdysone-dependent manner (PubMed:14603321). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).

(UniProt, P34021)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\EcR using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (84 terms)
Molecular Function (18 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
DNA binding
inferred from direct assay
(Johnston et al., 2011)
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Koelle et al., 1991)
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964
(Zelhof et al., 1995)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Chanut-Delalande et al., 2014)
ecdysone binding
inferred from direct assay
(Yao et al., 1993, Koelle et al., 1991)
nuclear receptor activity
inferred from direct assay
(Talbot et al., 1993, Koelle et al., 1991)
contributes_to nuclear receptor activity
inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964
(Zelhof et al., 1995)
protein binding
inferred from physical interaction with FLYBASE:Utx; FB:FBgn0260749
(Denton et al., 2013)
inferred from physical interaction with FLYBASE:rig; FB:FBgn0250850
(Gates et al., 2004)
inferred from physical interaction with UniProtKB:Q9VCH5
(assigned by UniProt )
(Pascual-Garcia et al., 2017)
protein heterodimerization activity
inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964
(Zelhof et al., 1995)
repressing transcription factor binding
inferred from physical interaction with FLYBASE:alien; FB:FBgn0013746
(Dressel et al., 1999)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from direct assay
(Denton et al., 2013)
RNA polymerase II transcription coactivator binding
inferred from physical interaction with FLYBASE:crc; FB:FBgn0000370
(Gauthier et al., 2012)
transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Lehmann and Korge, 1995)
Terms Based on Predictions or Assertions (12 terms)
CV Term
Evidence
References
DNA binding
non-traceable author statement
(Kozlova and Thummel, 2000)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
ligand-activated transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
nuclear receptor activity
inferred from sequence or structural similarity with MGI:MGI:1352464
(FlyBase Curators, 2008--)
non-traceable author statement
(Maglich et al., 2001)
nuclear receptor transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
steroid binding
non-traceable author statement
(Kozlova and Thummel, 2000)
steroid hormone receptor activity
inferred from electronic annotation with InterPro:IPR001723
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
zinc ion binding
inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (58 terms)
Terms Based on Experimental Evidence (47 terms)
CV Term
Evidence
References
autophagy
inferred from mutant phenotype
(Rusten et al., 2004)
border follicle cell migration
inferred from mutant phenotype
(Jang et al., 2009, Medioni and Noselli, 2005, Bai et al., 2000)
cardiac muscle tissue development
inferred from mutant phenotype
(Monier et al., 2005)
cardioblast differentiation
inferred from mutant phenotype
(Monier et al., 2005)
cell adhesion
inferred from mutant phenotype
(D'Avino and Thummel, 2000)
chitin-based cuticle development
inferred from mutant phenotype
(Chanut-Delalande et al., 2014)
chitin-based embryonic cuticle biosynthetic process
inferred from mutant phenotype
(Kozlova and Thummel, 2003)
cholesterol homeostasis
inferred from mutant phenotype
(Danielsen et al., 2016)
determination of adult lifespan
inferred from mutant phenotype
(Simon et al., 2003)
dorsal vessel heart proper cell fate commitment
inferred from mutant phenotype
(Monier et al., 2005)
ecdysis, chitin-based cuticle
inferred from mutant phenotype
(Li and Bender, 2000)
ecdysone receptor-mediated signaling pathway
inferred from mutant phenotype
(Li and Bender, 2000)
inferred from mutant phenotype
(assigned by UniProt )
(Okamoto et al., 2018)
epidermis development
inferred from mutant phenotype
(Ninov et al., 2007)
germ cell development
inferred from mutant phenotype
(König et al., 2011)
germ-band shortening
inferred from mutant phenotype
(Kozlova and Thummel, 2003)
hatching
inferred from mutant phenotype
(Li and Bender, 2000)
head involution
inferred from mutant phenotype
(Kozlova and Thummel, 2003)
histoblast morphogenesis
inferred from mutant phenotype
(Ninov et al., 2007)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(D'Avino and Thummel, 2000)
inferred from genetic interaction with FLYBASE:if; FB:FBgn0001250
(D'Avino and Thummel, 2000)
inferred from genetic interaction with FLYBASE:mys; FB:FBgn0004657
(D'Avino and Thummel, 2000)
larval central nervous system remodeling
inferred from mutant phenotype
(Brown and Truman, 2009, Brown et al., 2006)
larval development
inferred from mutant phenotype
(assigned by UniProt )
(Okamoto et al., 2018)
larval wandering behavior
inferred from mutant phenotype
(Davis et al., 2005)
long-term memory
inferred from mutant phenotype
(Ishimoto et al., 2009)
Malpighian tubule morphogenesis
inferred from mutant phenotype
(Gautam and Tapadia, 2010)
metamorphosis
inferred from mutant phenotype
(Li and Bender, 2000)
mushroom body development
inferred from mutant phenotype
(Kucherenko et al., 2012, Lin et al., 2009)
inferred from genetic interaction with FLYBASE:babo; FB:FBgn0011300
(Zheng et al., 2003)
inferred from genetic interaction with FLYBASE:Smox; FB:FBgn0025800
(Zheng et al., 2003)
neuron remodeling
inferred from mutant phenotype
(Lin et al., 2009, Roy et al., 2007, Brown et al., 2006, Awasaki and Ito, 2004, Lee et al., 2000)
oogenesis
inferred from mutant phenotype
(Carney and Bender, 2000)
peripheral nervous system development
inferred from mutant phenotype
(Schubiger et al., 2005)
phagocytosis, engulfment
inferred from mutant phenotype
(Tasdemir-Yilmaz and Freeman, 2014)
positive regulation of apoptotic process
inferred from mutant phenotype
(Sprecher and Desplan, 2008)
positive regulation of circadian sleep/wake cycle, sleep
inferred from mutant phenotype
(Ishimoto and Kitamoto, 2010)
positive regulation of neuron remodeling
inferred from mutant phenotype
(Wong et al., 2013)
positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Chanut-Delalande et al., 2014, Gauthier et al., 2012)
inferred from genetic interaction with FLYBASE:Sgs4; FB:FBgn0003374
(Lehmann and Korge, 1995)
positive regulation of transcription, DNA-templated
inferred from mutant phenotype
(Bernardi et al., 2009)
pupariation
inferred from mutant phenotype
(Davis et al., 2005, Li and Bender, 2000)
regulation of autophagy
inferred from mutant phenotype
(Liu et al., 2013)
regulation of cellular respiration
inferred from mutant phenotype
(Homem et al., 2014)
regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
regulation of Malpighian tubule diameter
inferred from mutant phenotype
(Gautam and Tapadia, 2010)
regulation of neuron remodeling
inferred from mutant phenotype
(Loncle and Williams, 2012)
regulation of rhodopsin gene expression
inferred from mutant phenotype
(Sprecher and Desplan, 2008)
regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(D'Avino and Thummel, 2000)
response to cocaine
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Willard et al., 2006)
response to ecdysone
inferred from mutant phenotype
(Johnston et al., 2011)
salivary gland cell autophagic cell death
inferred from mutant phenotype
(Ihry and Bashirullah, 2014)
sperm individualization
inferred from mutant phenotype
(Fabrizio et al., 1998)
Terms Based on Predictions or Assertions (15 terms)
CV Term
Evidence
References
cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
cellular response to lipopolysaccharide
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
cholesterol homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
dendrite morphogenesis
non-traceable author statement
(Grueber and Jan, 2004)
ecdysone-mediated induction of salivary gland cell autophagic cell death
non-traceable author statement
(Buszczak and Segraves, 2000)
larval central nervous system remodeling
traceable author statement
(Tissot and Stocker, 2000)
lipid homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
lipid metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
multicellular organism development
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of transcription, DNA-templated
traceable author statement
(Kozlova and Thummel, 2000)
oogenesis
non-traceable author statement
(Kozlova and Thummel, 2000)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of development, heterochronic
traceable author statement
(Thummel, 2001)
response to lipid
inferred from biological aspect of ancestor with PANTHER:PTN000637752
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
activator ecdysone receptor complex
inferred from direct assay
(Lehmann and Korge, 1995)
cytoplasm
inferred from direct assay
(Brennan et al., 2001)
dendrite
inferred from mutant phenotype
(Kuo et al., 2005)
ecdysone receptor holocomplex
inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964
(Zelhof et al., 1995)
nucleus
inferred from direct assay
(Johnston et al., 2011, Carney and Bender, 2000, Lehmann and Korge, 1995, Talbot et al., 1993, Koelle et al., 1991)
polytene chromosome
inferred from direct assay
(assigned by UniProt )
(Carbonell et al., 2013)
repressor ecdysone receptor complex
inferred from physical interaction with FLYBASE:alien; FB:FBgn0013746
(Dressel et al., 1999)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
ecdysone receptor holocomplex
traceable author statement
(Buszczak and Segraves, 2000)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
polytene chromosome
non-traceable author statement
(Kozlova and Thummel, 2000)
RNA polymerase II transcription factor complex
inferred from biological aspect of ancestor with PANTHER:PTN000637751
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
second instar larval stage
(Talbot et al., 1993)
embryonic stage 1 -- 6

Comment: reference states 0-3 hr AEL

(Talbot et al., 1993)
wandering third instar larval stage
organism
(Talbot et al., 1993)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7 -- 17

Comment: reference states >=3 hr AEL

(Koelle et al., 1991)
first instar larval stage
(Talbot et al., 1993)
third instar larval stage
(Talbot et al., 1993)
larval stage -- adult stage
(Koelle et al., 1991)
pupal stage
(Talbot et al., 1993)
embryonic stage 12 -- 17
organism
(Talbot et al., 1993)
embryonic stage 1 -- 6
organism
(Talbot et al., 1993)
prepupal stage P1 -- pharate adult stage P9
organism
(Talbot et al., 1993)
wandering third instar larval stage
organism
(Ritter and Beckstead, 2010)
prepupal stage P4 -- pupal stage P5
organism
(Ritter and Beckstead, 2010)
Additional Descriptive Data

The temporal pattern of EcR RNA expression was carefully studied and related to times of ecdysone pulses. Peaks of the 5kb EcR-A RNA occur in mid-embryogenesis and early and late in pupation.

(Talbot et al., 1993)

The temporal pattern of EcR RNA expression was carefully studied and related to times of ecdysone pulses. The strongest peak of EcR-B1 RNA expression occurs in late third instar larvae. Smaller peaks are observed during late embryonic, late first and second instar larval, and mid pupal stages.

(Talbot et al., 1993)

The 6 kb EcR transcript is detected in all stages except for 0-3 hr embryos. Expression is most abundant in embryos and in late third instar larvae and early pupae, with highest levels seen in wandering third instar larvae.

(Koelle et al., 1991)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
prepupal stage
midgut imaginal island
(Talbot et al., 1993)
epidermis
(Talbot et al., 1993)
embryonic/larval muscle system
(Talbot et al., 1993)
embryonic/larval midgut
(Talbot et al., 1993)
embryonic/larval trachea
(Talbot et al., 1993)
haltere disc
(Talbot et al., 1993)
imaginal disc
(Talbot et al., 1993)
foregut imaginal ring
(Talbot et al., 1993)
ventral thoracic disc
(Talbot et al., 1993)
first instar larval stage
(Talbot et al., 1993)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron | subset
(Robinow et al., 1993)
adult brain
(Schwedes et al., 2011, Ishimoto et al., 2009)
ventral nerve cord
(Schwedes et al., 2011)
adult fat body
(Schwedes et al., 2011)
adult oenocyte
(Schwedes et al., 2011)
adult proventriculus
(Schwedes et al., 2011)
adult midgut
(Schwedes et al., 2011)
adult hindgut
(Schwedes et al., 2011)
adult posterior hindgut
(Schwedes et al., 2011)
adult Malpighian tubule
(Schwedes et al., 2011)
pupal stage P5 -- pharate adult stage P15
neuron | subset

Comment: reference states >=12 hr APF

(Robinow et al., 1993)
ventral nervous system | restricted

Comment: reference states >=12 hr APF

(Robinow et al., 1993)
prepupal stage
Malpighian tubule
(Talbot et al., 1993)
embryonic/larval fat body
(Talbot et al., 1993)
embryonic/larval salivary gland
(Talbot et al., 1993)
eye-antennal disc
(Talbot et al., 1993)
foregut imaginal ring
(Talbot et al., 1993)
hindgut imaginal ring
(Talbot et al., 1993)
histoblast nest
(Talbot et al., 1993)
labial disc
(Talbot et al., 1993)
prothoracic gland
(Talbot et al., 1993)
salivary gland imaginal ring
(Talbot et al., 1993)
pupal stage
mushroom body gamma-lobe
(Watts et al., 2003)
projection neuron | subset
(Marin et al., 2005)
larval stage -- adult stage
adult CSD interneuron
(Roy et al., 2007)
third instar larval stage
Kenyon cell
(Takaesu et al., 2012)
embryonic stage 4 -- 5
organism
(Johnston et al., 2011)
early third instar larval stage -- prepupal stage P2
embryonic/larval salivary gland
(Johnston et al., 2011)
oogenesis
egg chamber | ubiquitous
(Jang et al., 2009)
oogenesis stage S9
centripetally migrating follicle cell

Comment: isoform "B1"

(Jang et al., 2009)
nurse follicle cell

Comment: isoform "B1"

(Jang et al., 2009)
adult stage | female
follicle cell
(Schwedes et al., 2011)
adult stage | male
male accessory gland
(Schwedes et al., 2011)
testis
(Schwedes et al., 2011)
seminal vesicle
(Schwedes et al., 2011)
ejaculatory bulb
(Schwedes et al., 2011)
ejaculatory duct
(Schwedes et al., 2011)
prepupal stage P1
reticular neuropil associated glial cell

Comment: isoform specific

(Tasdemir-Yilmaz and Freeman, 2014)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis
nurse cell
(Carney and Bender, 2000)
follicle cell
(Carney and Bender, 2000)
wandering third instar larval stage
organism
(Koelle et al., 1991)
prepupal stage
(Koelle et al., 1991)
pupal stage
(Talbot et al., 1993, Koelle et al., 1991)
adult stage
(Koelle et al., 1991)
ovary
(Carney and Bender, 2000)
embryonic stage
(Talbot et al., 1993, Koelle et al., 1991)
organism
(Talbot et al., 1993)
first instar larval stage
(Koelle et al., 1991)
Additional Descriptive Data

At 0h APF, reticular neuropil associated glial cells (astrocyte-like cells) express "EcR-B1" (EcR-RB), but not "EcR-A" (EcR-RA, EcR-RD) <up>isoform identities obtained from UniProt</up>.

(Tasdemir-Yilmaz and Freeman, 2014)

EcR staining is widespread in the adult brain.

(Ishimoto et al., 2009)

EcR isoform "A" is uniformly distributed in egg chambers at all stages. Isoform "B1" is more highly expressed in follicle cells than germline cells and shows a fourfold enrichment in anterior follicle cells at early oogenesis stage S9. The enrichment is reduced by mid stage 9 and absent by stage 10.

(Jang et al., 2009)

EcR is expressed in approximately 20 antennal lobe projection neurons, 18 of which are located in a anterodorsal cluster.

(Marin et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
activator ecdysone receptor complex
inferred from direct assay
(Lehmann and Korge, 1995)
cytoplasm
inferred from direct assay
(Brennan et al., 2001)
dendrite
inferred from mutant phenotype
(Kuo et al., 2005)
ecdysone receptor holocomplex
inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964
(Zelhof et al., 1995)
nucleus
inferred from direct assay
(Johnston et al., 2011, Carney and Bender, 2000, Lehmann and Korge, 1995, Talbot et al., 1993, Koelle et al., 1991)
polytene chromosome
inferred from direct assay
(assigned by UniProt )
(Carbonell et al., 2013)
repressor ecdysone receptor complex
inferred from physical interaction with FLYBASE:alien; FB:FBgn0013746
(Dressel et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\EcR in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 114 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 41 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of EcR
Transgenic constructs containing regulatory region of EcR
Deletions and Duplications ( 15 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4A9
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4dpp.blk1
lethal, with Scer\GAL4Eip71CD.602
lethal, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
lethal, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4Lsp2.PH
lethal, with Scer\GAL4phm.PU
lethal, with Scer\GAL4ple.PF
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4Ser.PGF
lethal, with Spyo\Cas9UAS.Tag:NLS(Unk)
lethal (with Df(2R)ED1482)
lethal (with Df(2R)ED1552)
lethal (with EcR31)
lethal (with EcR99)
lethal (with EcR112)
lethal (with EcR139)
lethal (with EcRM554fs)
lethal | embryonic stage
lethal | embryonic stage, with Scer\GAL469B
lethal | embryonic stage, with Scer\GAL4c381
lethal | heat sensitive
lethal | heat sensitive, with Scer\GAL4dpp.blk1
lethal | heat sensitive (with EcRA483T)
lethal | heat sensitive (with EcRNP5219)
lethal | larval stage
lethal | larval stage, with Scer\GAL469B
lethal | larval stage, with Scer\GAL4c381
lethal | nutrition conditional, with Scer\GAL4r4
lethal | pharate adult stage (with EcR112)
lethal | pharate adult stage (with EcRM554fs)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | pupal stage (with EcR112)
lethal | pupal stage (with EcR139)
lethal | pupal stage (with EcRM554fs)
lethal | recessive
lethal | recessive | heat sensitive
lethal | second instar larval stage (with EcR172)
lethal | second instar larval stage (with EcRM554fs)
lethal | third instar larval stage (with EcR94)
lethal | third instar larval stage (with EcRM554fs)
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage, with Scer\GAL4arm.PS
lethal - all die before end of embryonic stage (with EcR52)
lethal - all die before end of embryonic stage (with EcR120)
lethal - all die before end of embryonic stage (with EcRM554fs)
lethal - all die before end of embryonic stage (with EcRV559fs)
lethal - all die before end of embryonic stage (with EcRW53st)
lethal - all die before end of embryonic stage | heat sensitive
lethal - all die before end of embryonic stage | heat sensitive, with EcRGAL4::LBD.hs
lethal - all die before end of embryonic stage | heat sensitive, with EcRM554fs
lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4hs.PB
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of first instar larval stage, with Scer\GAL4C57
lethal - all die before end of first instar larval stage, with Scer\GAL4tsh-c724
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4c649
lethal - all die before end of larval stage, with Scer\GAL4RapGAP1-OK6
lethal - all die before end of larval stage (with EcR94)
lethal - all die before end of larval stage (with EcRM554fs)
lethal - all die before end of larval stage | heat sensitive
lethal - all die before end of larval stage | recessive
lethal - all die before end of prepupal stage | heat sensitive
lethal - all die before end of P-stage, with Scer\GAL4da.G32
lethal - all die before end of P-stage, with Scer\GAL4repo
lethal - all die before end of pupal stage, with Scer\GAL4GMR.PF
lethal - all die before end of pupal stage, with Scer\GAL4Mhc.PW
lethal - all die before end of pupal stage, with Scer\GAL4Tab2-201Y
lethal - all die during embryonic stage, with Scer\GAL4Tub.PU
lethal - all die during first instar larval stage, with Scer\GAL4c42
lethal - all die during larval stage, with Scer\GAL4r4
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4en-e16E
partially lethal | heat sensitive
partially lethal - majority die, with Scer\GAL4phm.PU
partially lethal - majority die (with EcR11)
partially lethal - majority die (with EcR31)
partially lethal - majority die (with EcR99)
partially lethal - majority die (with EcRM554fs)
partially lethal - majority die (with EcRW53st)
partially lethal - majority die | first instar larval stage (with EcR172)
partially lethal - majority die | first instar larval stage (with EcRM554fs)
partially lethal - majority die | pharate adult stage (with EcR139)
partially lethal - majority die | pharate adult stage (with EcRM554fs)
partially lethal - majority die | pharate adult stage | recessive
partially lethal - majority die | prepupal stage (with EcR112)
partially lethal - majority die | prepupal stage (with EcRM554fs)
partially lethal - majority die | pupal stage (with EcR112)
partially lethal - majority die | pupal stage (with EcR139)
partially lethal - majority die | pupal stage (with EcRM554fs)
partially lethal - majority die | recessive
partially lethal - majority die | second instar larval stage (with EcR94)
partially lethal - majority die | second instar larval stage (with EcR112)
partially lethal - majority die | second instar larval stage (with EcR139)
partially lethal - majority die | second instar larval stage (with EcRM554fs)
partially lethal - majority die | third instar larval stage (with EcR112)
partially lethal - majority die | third instar larval stage (with EcR139)
partially lethal - majority die | third instar larval stage (with EcRM554fs)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4ey-OK107
viable, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
viable, with Scer\GAL4Sgs3.PD
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4slbo.2.6
female sterile | recessive | heat sensitive
male fertile, with Scer\GAL4nos.PG
male sterile
male sterile | recessive
Other Phenotypes
Allele
body size defective | larval stage, with Scer\GAL4c42
cell death defective
cell migration defective | pupal stage, with Scer\GAL4Cg.PA
cell shape defective | somatic clone, with Scer\GAL4e22c
circadian rhythm defective, with Scer\GAL4P2.4.Pdf
courtship behavior defective | conditional | dominant
courtship behavior defective | RU486 conditional, with Scer\GAL4elav.Switch.PO
courtship behavior defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch
decreased cell death, with Scer\GAL4Crz.PC
decreased cell death (with EcR31)
decreased cell death (with EcR99)
decreased cell death | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
decreased cell death | pupal stage, with Scer\GAL4Crz.PU
decreased cell number | larval stage, with Scer\GAL4c42
decreased cell number | third instar larval stage (with EcR31)
decreased cell number | third instar larval stage (with EcR99)
decreased cell size | cell autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
decreased cell size | somatic clone, with Scer\GAL4e22c
decreased cell size | third instar larval stage, with Scer\GAL4fkh.PH
decreased fecundity | female (with EcRA483T)
decreased fecundity | female (with EcRM554fs)
decreased fecundity | female (with EcRR344Q)
decreased fecundity | female (with EcRV559fs)
decreased fecundity | female | RU486 conditional, with Scer\GAL4da.Switch.PT
decreased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4Act5C.PP
decreased occurrence of cell division | third instar larval stage, with EcRM554fs/EcRV559fs
decreased occurrence of cell division | third instar larval stage (with EcRM554fs), with EcRB2.hs
decreased occurrence of cell division | third instar larval stage (with EcRV559fs), with EcRB2.hs
developmental rate defective, with Scer\GAL4c42
developmental rate defective, with Scer\GAL4c649
developmental rate defective, with Scer\GAL4Lsp2.PH
developmental rate defective | pupal stage (with EcR112)
developmental rate defective | pupal stage (with EcR139)
developmental rate defective | pupal stage (with EcRM554fs)
feeding behavior defective | third instar larval stage (with EcR112)
feeding behavior defective | third instar larval stage (with EcR139)
feeding behavior defective | third instar larval stage (with EcRM554fs)
increased cell death | early third instar larval stage, with Scer\GAL4CCAP.PP
increased cell death | second instar larval stage, with Scer\GAL4CCAP.PP
increased cell death | third instar larval stage, with Scer\GAL4Burs.PL
increased cell death | wandering third instar larval stage, with Scer\GAL4CCAP.PP
increased fecundity | dominant | female
locomotor behavior defective, with Scer\GAL4c42
locomotor behavior defective | adult stage | dominant
locomotor behavior defective | third instar larval stage (with EcR112)
locomotor behavior defective | third instar larval stage (with EcR139)
locomotor behavior defective | third instar larval stage (with EcRM554fs)
long lived
long lived | dominant
long lived | male | RU486 conditional, with Scer\GAL4Switch1.106
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
majority die during larval stage (with EcR112)
majority die during larval stage (with EcR139)
majority die during larval stage (with EcRM554fs)
melanotic mass phenotype | larval stage, with Scer\GAL4A9
memory defective | dominant
memory defective | dominant | heat sensitive
memory defective | RU486 conditional, with Scer\GAL4elav.Switch.PO
memory defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4109(2)80
neuroanatomy defective, with Scer\GAL4alrm.PD
neuroanatomy defective, with Scer\GAL4c739
neuroanatomy defective, with Scer\GAL4FMRFa.PS
neuroanatomy defective, with Scer\GAL4let7C
neuroanatomy defective, with Scer\GAL4Mhc.PW
neuroanatomy defective, with Scer\GAL4ppk.1.9
neuroanatomy defective, with Scer\GAL4Tab2-201Y
neuroanatomy defective, with Scer\GAL4αTub84B.PP
neuroanatomy defective (with EcR31)
neuroanatomy defective (with EcR99)
neuroanatomy defective | adult stage, with Scer\GAL4ey-OK107
neuroanatomy defective | adult stage, with Scer\GAL4GMR71G10
neuroanatomy defective | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
neuroanatomy defective | early third instar larval stage, with Scer\GAL4CCAP.PP
neuroanatomy defective | larval stage, with Scer\GAL4RapGAP1-OK6
neuroanatomy defective | pupal stage, with Scer\GAL4Crz.PU
neuroanatomy defective | pupal stage, with Scer\GAL4lilli-189Y
neuroanatomy defective | pupal stage, with Scer\GAL4NP3056
neuroanatomy defective | pupal stage, with Scer\GAL4orb-0449-G4
neuroanatomy defective | pupal stage, with Scer\GAL4ppk.PG
neuroanatomy defective | pupal stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
neuroanatomy defective | pupal stage (with EcR112)
neuroanatomy defective | pupal stage (with EcR139)
neuroanatomy defective | pupal stage (with EcRM554fs)
neuroanatomy defective | second instar larval stage, with Scer\GAL4CCAP.PP
neuroanatomy defective | third instar larval stage, with Scer\GAL4Burs.PL
neuroanatomy defective | wandering third instar larval stage, with Scer\GAL4CCAP.PP
short lived | female | RU486 conditional, with Scer\GAL4da.Switch.PT
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
short lived | RU486 conditional, with Scer\GAL4da.Switch.PT
size defective, with Scer\GAL4ey-OK107
size defective | pupal stage, with Scer\GAL4CCAP.PP
size defective | pupal stage (with EcR112)
size defective | pupal stage (with EcR139)
size defective | pupal stage (with EcRM554fs)
sleep defective, with Scer\GAL4Mef2.247.Switch
sleep defective | dominant
sleep defective | heat sensitive (with EcRA483T)
sleep defective | heat sensitive (with EcRNP5219)
small body | larval stage, with Scer\GAL4c649
small body | larval stage, with Scer\GAL4tsh-c724
some die during embryonic stage
some die during embryonic stage, with Scer\GAL4arm.PS
some die during embryonic stage (with EcR52)
some die during embryonic stage (with EcR120)
some die during embryonic stage (with EcRM554fs)
some die during embryonic stage (with EcRV559fs)
some die during embryonic stage (with EcRW53st)
some die during embryonic stage | heat sensitive
some die during embryonic stage | heat sensitive, with EcRGAL4::LBD.hs
some die during embryonic stage | heat sensitive, with EcRM554fs
some die during embryonic stage | heat sensitive, with Scer\GAL4hs.PB
some die during embryonic stage | recessive
some die during first instar larval stage, with Scer\GAL4C57
some die during first instar larval stage, with Scer\GAL4tsh-c724
some die during larval stage
some die during larval stage, with Scer\GAL4A9
some die during larval stage, with Scer\GAL4c649
some die during larval stage, with Scer\GAL4RapGAP1-OK6
some die during larval stage (with EcR31)
some die during larval stage (with EcR99)
some die during larval stage | heat sensitive
some die during larval stage | recessive
some die during pharate adult stage, with Scer\GAL4da.G32
some die during pharate adult stage, with Scer\GAL4repo
some die during prepupal stage | recessive (with EcR112)
some die during prepupal stage | recessive (with EcR139)
some die during prepupal stage | recessive (with EcRM554fs)
some die during prepupal stage | recessive | heat sensitive
some die during pupal stage, with Scer\GAL4A9
some die during pupal stage, with Scer\GAL4GMR.PF
some die during pupal stage, with Scer\GAL4Mhc.PW
some die during pupal stage, with Scer\GAL4Tab2-201Y
some die during pupal stage (with EcR11)
some die during pupal stage (with EcR112)
some die during pupal stage (with EcR139)
some die during pupal stage (with EcRM554fs)
some die during pupal stage (with EcRW53st)
some die during third instar larval stage (with EcR94)
some die during third instar larval stage (with EcRM554fs)
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4c42
visible, with Scer\GAL4GMR.PU
visible | pupal stage, with Scer\GAL4CCAP.PP
visible | recessive | somatic clone
Phenotype manifest in
Allele
adult brain (with EcR31)
adult brain (with EcRW53st)
adult CSD interneuron, with Scer\GAL4αTub84B.PP
adult midgut
adult mushroom body, with Scer\GAL4ey-OK107
adult mushroom body (with EcR31)
adult mushroom body (with EcRW53st)
amnioserosa, with Scer\GAL4da.G32
anterior crossvein | ectopic
anterior pupal spiracle (with EcR94)
anterior pupal spiracle (with EcRM554fs)
autolysosome, with Scer\GAL4Lsp2.PH
autophagosome, with Scer\GAL4Lsp2.PH
axon | adult stage, with Scer\GAL4GMR71G10
axon | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
border follicle cell, with Scer\GAL4slbo.2.6
cephalopharyngeal skeleton, with EcRM554fs/EcRV559fs
cephalopharyngeal skeleton, with Scer\GAL469B
cephalopharyngeal skeleton (with EcRM554fs), with EcRB2.hs
cephalopharyngeal skeleton (with EcRV559fs), with EcRB2.hs
chorion, with Scer\GAL4slbo.2.6
dendrite, with Scer\GAL4109(2)80
dendrite, with Scer\GAL4ppk.1.9
dendrite, with Scer\GAL4Tab2-201Y
dendritic arborizing neuron | P-stage, with Scer\GAL4ppk.PG
denticle belt, with Scer\GAL469B
dorsal appendage, with Scer\GAL4slbo.2.6
dorsal appendage | maternal effect, with Scer\GAL4slbo.2.6
dorsal pouch
egg chamber
egg chamber | germline clone
egg chamber | heat sensitive
egg operculum, with Scer\GAL4slbo.2.6
embryo | dorsal closure stage
embryo | dorsal closure stage, with Scer\GAL469B
embryo | dorsal closure stage, with Scer\GAL4hs.PB
embryo | embryonic stage 14
embryo | embryonic stage 14, with Scer\GAL469B
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4c42
embryonic/first instar larval cuticle, with Scer\GAL4hs.PB
embryonic/larval adipose system, with Scer\GAL4c42
embryonic/larval cuticle, with EcRM554fs/EcRV559fs
embryonic/larval cuticle (with EcRM554fs), with EcRB2.hs
embryonic/larval cuticle (with EcRV559fs), with EcRB2.hs
embryonic/larval digestive system | larval stage, with Scer\GAL4A9
embryonic/larval epidermis, with Scer\GAL4NP0056
embryonic/larval fat body, with Scer\GAL4Lsp2.PH
embryonic/larval Malpighian tubule, with Scer\GAL4c42
embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4c649
embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4tsh-c724
embryonic/larval Malpighian tubule Type I cell, with Scer\GAL4c42
embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4c42
embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4c649
embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4tsh-c724
embryonic/larval midgut, with Scer\GAL4da.G32
embryonic/larval midgut | embryonic stage
embryonic/larval midgut | heat sensitive
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4RapGAP1-OK6
embryonic/larval posterior spiracle, with EcRM554fs/EcRV559fs
embryonic/larval posterior spiracle (with EcRM554fs), with EcRB2.hs
embryonic/larval posterior spiracle (with EcRV559fs), with EcRB2.hs
embryonic/larval salivary gland | cell autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval salivary gland | embryonic stage, with EcRM554fs/EcRV559fs
embryonic/larval salivary gland | embryonic stage (with EcRM554fs), with EcRB2.hs
embryonic/larval salivary gland | embryonic stage (with EcRV559fs), with EcRB2.hs
embryonic/larval salivary gland | heat sensitive
embryonic/larval salivary gland | prepupal stage, with Scer\GAL4Sgs3.PD
embryonic/larval salivary gland | pupal stage, with Scer\GAL4Sgs3.PD
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4fkh.PH
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4Sgs3.PD
embryonic/larval tracheal system
embryonic/larval tracheal system | heat sensitive, with Scer\GAL4btl.PS
embryonic head
embryonic midgut constriction
epipharyngeal sclerite
eye
eye, with Scer\GAL4ey-OK107
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | somatic clone
fat body, with Scer\GAL4Lsp2.PH
fat cell | pupal stage, with Scer\GAL4Cg.PA
female germline cell | somatic clone | supernumerary, with Scer\GAL4Act.PU
female germline cell | supernumerary, with Scer\GAL4bab1-Pgal4-2
female germline cell | supernumerary | heat sensitive
follicle cell | heat sensitive
fusome | heat sensitive
gamma Kenyon cell, with Scer\GAL4alrm.PD
gamma Kenyon cell, with Scer\GAL4Tab2-201Y
gamma Kenyon cell | adult stage, with Scer\GAL4GMR71G10
gamma Kenyon cell | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
gamma Kenyon cell | somatic clone, with Scer\GAL4alrm.PD
gamma-lobe & neuron (with EcR31)
gamma-lobe & neuron (with EcRW53st)
gastric caecum, with EcRM554fs/EcRV559fs
gastric caecum (with EcRM554fs), with EcRB2.hs
gastric caecum (with EcRV559fs), with EcRB2.hs
gastric caecum | heat sensitive
germarium cap cell | supernumerary, with Scer\GAL4bab1-Pgal4-2
germ band, with EcRB1-ΔC655.F645A.UAS, Scer\GAL469B
germ band, with EcRB1-ΔC655.F645A.UAS, Scer\GAL4c381
germ band, with EcRGAL4::LBD.hs
germ band, with EcRM554fs
germ band, with EcRM554fs, Scer\GAL469B
germ band, with EcRM554fs, Scer\GAL4c381
germline cell | supernumerary | heat sensitive, with Scer\GAL4bab1-Pgal4-2, Scer\GAL80ts.αTub84B
germline cell | supernumerary | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B
glial cell & brain & pupa | conditional ts, with Scer\GAL4Tab2-201Y
head | pharate adult stage (with EcR112)
head | pharate adult stage (with EcRM554fs)
head | pupal stage, with Scer\GAL4Cg.PA
histoblast nest
imaginal disc, with Scer\GAL4Eip71CD.657
imaginal disc | heat sensitive
labral segment
larva
larval CCAP abdominal neuron | pupal stage (with EcR112)
larval CCAP abdominal neuron | pupal stage (with EcR139)
larval CCAP abdominal neuron | pupal stage (with EcRM554fs)
larval CCAP neuron | early third instar larval stage, with Scer\GAL4CCAP.PP
larval CCAP neuron | second instar larval stage, with Scer\GAL4CCAP.PP
larval CCAP neuron | third instar larval stage, with Scer\GAL4Burs.PL
larval CCAP neuron | third instar larval stage (with EcR31)
larval CCAP neuron | third instar larval stage (with EcR99)
larval CCAP neuron | wandering third instar larval stage, with Scer\GAL4CCAP.PP
larval dorsal multidendritic neuron ddaC, with Scer\GAL4109(2)80
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval thoracic neuromere | somatic clone, with Scer\GAL4elav-C155
leg
leg | adult stage | somatic clone, with Scer\GAL4elav-C155
leg | pharate adult stage
leg | pharate adult stage (with EcR112)
leg | pharate adult stage (with EcR139)
leg | pharate adult stage (with EcRM554fs)
leg | pupal stage, with Scer\GAL4CCAP.PP
lobe system of adult mushroom body
lobe system of adult mushroom body, with Scer\GAL4c739
lobe system of adult mushroom body, with Scer\GAL4let7C
local interneuron of larval antennal lobe | pupal stage, with Scer\GAL4lilli-189Y
local interneuron of larval antennal lobe | pupal stage, with Scer\GAL4NP3056
local interneuron of larval antennal lobe | pupal stage, with Scer\GAL4orb-0449-G4
lysosome, with Scer\GAL4Lsp2.PH
mesothoracic ventral neurosecretory neuron & axon, with Scer\GAL4FMRFa.PS
metathoracic ventral thoracic neurosecretory neuron & axon, with Scer\GAL4FMRFa.PS
microtubule & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG
midgut, with Scer\GAL4twi.PG
midgut imaginal island
midgut imaginal island, with EcRM554fs/EcRV559fs
midgut imaginal island (with EcRM554fs), with EcRB2.hs
midgut imaginal island (with EcRV559fs), with EcRB2.hs
mitotic domain 1 | extended germ band stage
mitotic domain 1 | extended germ band stage, with Scer\GAL469B
mitotic domain 1 | extended germ band stage, with Scer\GAL4c381
mitotic domain 1 | extended germ band stage, with Scer\GAL4hs.PB
motor neuron | adult stage | somatic clone, with Scer\GAL4elav-C155
mouth hooks (with EcR112)
mouth hooks (with EcRM554fs)
mushroom body | P-stage, with Scer\GAL4Tab2-201Y
mushroom body beta-lobe
mushroom body beta-lobe, with Scer\GAL4c739
mushroom body beta-lobe, with Scer\GAL4let7C
mushroom body gamma-lobe | adult stage, with Scer\GAL4ey-OK107
neuroblast | larval stage | somatic clone, with Scer\GAL4elav-C155
neuroblast | pupal stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
neuroblast | pupal stage | somatic clone, with Scer\GAL4elav-C155
neurohemal organ, with Scer\GAL4FMRFa.PS
neuron & ventral nerve cord, with Scer\GAL4Crz.PC
neuron & ventral nerve cord (with EcR31)
neuron & ventral nerve cord (with EcR99)
nurse cell & nucleus | conditional ts
nurse cell ring canal | heat sensitive
ommatidium, with Scer\GAL4GMR.PF
oocyte | oogenesis stage S10B | somatic clone, with Scer\GAL4e22c
oocyte | oogenesis stage S14 | heat sensitive
peptidergic neuron | pupal stage, with Scer\GAL4Crz.PU
peripodial epithelium
photoreceptor, with Scer\GAL4GMR.PF
pigment cell, with Scer\GAL4GMR.PF
polar follicle cell, with Scer\GAL4slbo.2.6
polytene chromosome puff, with Scer\GAL4Sgs3.PD
posterior scutellar bristle, with Scer\GAL4dpp.blk1
prepupal cuticle, with Scer\GAL4en-e16E
primary spermatocyte cyst
prothoracic gland | third instar larval stage, with Scer\GAL4phm.PO
prothoracic ventral neurosecretory neuron & axon, with Scer\GAL4FMRFa.PS
pupa
pupa, with Scer\GAL4Eip71CD.657
pupal cuticle (with EcR139)
pupal cuticle (with EcRM554fs)
pupal epidermis, with Scer\GAL4NP0056
puparial operculum (with EcR112)
puparial operculum (with EcRM554fs)
puparium cuticle, with Scer\GAL4da.G32
puparium cuticle (with EcR94)
puparium cuticle (with EcR112)
puparium cuticle (with EcR139)
puparium cuticle (with EcRM554fs)
reticular neuropil associated glial cell, with Scer\GAL4alrm.PD
reticular neuropil associated glial cell | somatic clone, with Scer\GAL4alrm.PD
salivary gland
salivary gland (with EcR112)
salivary gland (with EcRM554fs)
spermatid
spermatid & nucleus
spermatozoon
synapse, with Scer\GAL4alrm.PD
synapse, with Scer\GAL4Mhc.PW
tergite
transverse nerve, with Scer\GAL4RapGAP1-OK6
Tv neuron & axon, with Scer\GAL4FMRFa.PS
Tv neuron & filopodium, with Scer\GAL4FMRFa.PS
ventral thoracic disc, with EcRM554fs/EcRV559fs
ventral thoracic disc (with EcRM554fs), with EcRB2.hs
ventral thoracic disc (with EcRV559fs), with EcRB2.hs
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4Eh.0.8
wing | pupal stage, with Scer\GAL4CCAP.PP
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing hair | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing margin | heat sensitive, with Scer\GAL4wg-IS650, Scer\GAL80ts.αTub84B
wing vein
wing vein, with Scer\GAL4Bx-MS1096
wing vein | ectopic
wing vein L3 | ectopic
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NR1H2
6 of 15
Yes
Yes
Hsap\NR1H3
6 of 15
Yes
Yes
 
Hsap\NR1H4
4 of 15
No
Yes
Hsap\NR1I2
1 of 15
No
No
Hsap\NR1I3
1 of 15
No
No
Hsap\RARA
1 of 15
No
No
Hsap\RARB
1 of 15
No
No
Hsap\RARG
1 of 15
No
Yes
Hsap\THRA
1 of 15
No
Yes
Hsap\THRB
1 of 15
No
Yes
Hsap\VDR
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nr1h2
6 of 15
Yes
Yes
Mmus\Nr1h3
6 of 15
Yes
Yes
Mmus\Nr1h5
5 of 15
No
Yes
Mmus\Nr1h4
4 of 15
No
Yes
Mmus\Nr1i2
1 of 15
No
No
Mmus\Nr1i3
1 of 15
No
No
Mmus\Rara
1 of 15
No
No
Mmus\Rarb
1 of 15
No
No
Mmus\Rarg
1 of 15
No
Yes
Mmus\Thra
1 of 15
No
Yes
Mmus\Thrb
1 of 15
No
Yes
Mmus\Vdr
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Nr1h2
5 of 13
Yes
Yes
Rnor\Nr1h3
5 of 13
Yes
Yes
Rnor\Nr1h5
5 of 13
Yes
Yes
Rnor\Nr1h4
3 of 13
No
Yes
Rnor\Nr1i2
1 of 13
No
No
Rnor\Nr1i3
1 of 13
No
No
Rnor\Rara
1 of 13
No
Yes
Rnor\Rarb
1 of 13
No
Yes
Rnor\Rarg
1 of 13
No
Yes
Rnor\Thra
1 of 13
No
Yes
Rnor\Thrb
1 of 13
No
Yes
Rnor\Vdr
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\nr1h2
5 of 12
Yes
Yes
Xtro\nr1h5
4 of 12
No
Yes
Xtro\exosc6
1 of 12
No
Yes
Xtro\nr1i2
1 of 12
No
No
Xtro\rara
1 of 12
No
Yes
Xtro\rarb
1 of 12
No
Yes
Xtro\thrb
1 of 12
No
Yes
Xtro\vdr
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\nr1h3
6 of 15
Yes
Yes
Drer\nr1h4
5 of 15
No
Yes
Drer\nr1h5
4 of 15
No
Yes
Drer\nr1i2
1 of 15
No
No
Drer\raraa
1 of 15
No
No
Drer\rarab
1 of 15
No
No
Drer\rarga
1 of 15
No
Yes
Drer\rargb
1 of 15
No
Yes
Drer\thraa
1 of 15
No
Yes
Drer\thrab
1 of 15
No
Yes
Drer\thrb
1 of 15
No
Yes
Drer\vdra
1 of 15
No
No
Drer\vdrb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (23)
Cele\daf-12
1 of 15
Yes
No
Cele\nhr-6
1 of 15
Yes
No
Cele\nhr-8
1 of 15
Yes
No
Cele\nhr-43
1 of 15
Yes
Yes
Cele\nhr-44
1 of 15
Yes
Yes
Cele\nhr-53
1 of 15
Yes
Yes
Cele\nhr-57
1 of 15
Yes
Yes
Cele\nhr-84
1 of 15
Yes
Yes
Cele\nhr-87
1 of 15
Yes
Yes
Cele\nhr-105
1 of 15
Yes
Yes
Cele\nhr-112
1 of 15
Yes
Yes
Cele\nhr-118
1 of 15
Yes
No
Cele\nhr-132
1 of 15
Yes
Yes
Cele\nhr-134
1 of 15
Yes
Yes
Cele\nhr-178
1 of 15
Yes
Yes
Cele\nhr-181
1 of 15
Yes
Yes
Cele\nhr-182
1 of 15
Yes
Yes
Cele\nhr-199
1 of 15
Yes
Yes
Cele\nhr-213
1 of 15
Yes
Yes
Cele\nhr-219
1 of 15
Yes
Yes
Cele\nhr-234
1 of 15
Yes
Yes
Cele\nhr-237
1 of 15
Yes
Yes
Cele\nhr-238
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190507 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\EcR
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006508
Drosophila simulans
Dsim\GD10334
Drosophila sechellia
Dsec\GM16480
Drosophila erecta
Dere\GG10830
Drosophila yakuba
Dyak\GE19426
Drosophila ananassae
Dana\GF13818
Drosophila pseudoobscura pseudoobscura
Dpse\EcR
Drosophila pseudoobscura pseudoobscura
Dpse\GA24101
Drosophila persimilis
Dper\GL16258
Drosophila willistoni
Dwil\GK21996
Drosophila virilis
Dvir\GJ20887
Drosophila mojavensis
Dmoj\GI21285
Drosophila grimshawi
Dgri\GH20948
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502N6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013895
Musca domestica
House fly
Mdoa\17008423
Glossina morsitans
Tsetse fly
Gmor\GMOY009122
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00763
Mayetiola destructor
Hessian fly
Mdes\Mdes003094
Aedes aegypti
Yellow fever mosquito
Aaeg\EcR
Anopheles darlingi
American malaria mosquito
Adar\ADAC008672
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002963
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06F1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006767
Danaus plexippus
Monarch butterfly
Dple\DPOGS208114-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012265
Apis florea
Little honeybee
Aflo\2330096244
Apis mellifera
Western honey bee
Amel\GB48059
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17599
Bombus terrestris
Buff-tailed bumblebee
Bter\15203348
Linepithema humile
Argentine ant
Lhum\LH16295
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0010c5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002543
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12837
Tribolium castaneum
Red flour beetle
Tcas\TC034305
Pediculus humanus
Human body louse
Phum\PHUM467460
Rhodnius prolixus
Kissing bug
Rpro\RPRC014174
Cimex lectularius
Bed bug
Clec\CLEC002129
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001692
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13925
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X079F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011767
Ixodes scapularis
Black-legged tick
Isca\ISCW003147
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66857.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15140
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_319648
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301472
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Eip75B
1 of 10
Hr96
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NR1H2; nuclear receptor subfamily 1 group H member 2
6 of 15
600380
      NR1H3; nuclear receptor subfamily 1 group H member 3
      6 of 15
      602423
           
          NR1H4; nuclear receptor subfamily 1 group H member 4
          4 of 15
          603826
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          EcR
          bimolecular fluorescence complementation, fluorescence microscopy
          (Dutko-Gwóźdź et al., 2008)
          EcR - 14-3-3ε
          fluorescent resonance energy transfer, fluorescence microscopy
          (Ng et al., 2017)
          EcR - Art1
          anti tag coimmunoprecipitation, western blot
          (Kimura et al., 2008)
          EcR - CG10209
          two hybrid array
          (Shokri et al., 2019)
          EcR - CSN4
          anti tag coimmunoprecipitation, anti tag western blot
          (Huang et al., 2014)
          EcR - CSN5
          anti tag coimmunoprecipitation, anti tag western blot
          (Huang et al., 2014)
          EcR - CTCF
          anti bait coimmunoprecipitation, western blot
          (Pascual-Garcia et al., 2017)
          EcR - Cdk8
          anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry, two hybrid
          (Xie et al., 2015)
          EcR - Chd64
          two hybrid, pull down, autoradiography
          (Li et al., 2007)
          EcR - CycC
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - DOR
          anti bait coimmunoprecipitation, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot, pull down
          (Xie et al., 2015, Francis et al., 2010)
          EcR - Dek
          pull down, western blot, anti tag coimmunoprecipitation
          (Sawatsubashi et al., 2010)
          EcR - ERR
          anti tag coimmunoprecipitation, anti tag western blot
          (Kovalenko et al., 2019)
          EcR - Fkbp39
          pull down, autoradiography, two hybrid
          (Li et al., 2007)
          EcR - Hr38
          bimolecular fluorescence complementation
          (Zoglowek et al., 2012)
          EcR - Hsc70-4
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - Kdm4A
          anti tag coimmunoprecipitation, western blot
          (Tsurumi et al., 2013)
          EcR - LKRSDH
          pull down, peptide massfingerprinting, autoradiography, anti bait coimmunoprecipitation, western blot
          (Cakouros et al., 2008)
          EcR - Lpt
          anti tag coimmunoprecipitation, western blot, pull down
          (Chauhan et al., 2012)
          EcR - MBD-like
          two hybrid array
          (Shokri et al., 2019)
          EcR - MED1
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - MED14
          two hybrid, anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - MED15
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - MED26
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - MED27
          anti tag coimmunoprecipitation, western blot
          (Homem et al., 2014)
          EcR - Met
          two hybrid, pull down, autoradiography
          (Bitra and Palli, 2009, Li et al., 2007)
          EcR - Mi-2
          pull down, autoradiography, anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining
          (Brehm, 2017.5.22, Kreher et al., 2017)
          EcR - Mtor
          anti bait coimmunoprecipitation, western blot
          (Pascual-Garcia et al., 2017)
          EcR - Nup98-96
          anti bait coimmunoprecipitation, western blot
          (Pascual-Garcia et al., 2017)
          EcR - Rel
          two hybrid array
          (Shokri et al., 2019)
          EcR - Smr
          two hybrid, anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015, Wang et al., 2006)
          EcR - Trf
          two hybrid array
          (Shokri et al., 2019)
          EcR - Usp7
          pull down, autoradiography
          (van der Knaap et al., 2010)
          EcR - Utx
          anti tag coimmunoprecipitation, western blot, pull down, autoradiography
          (Denton et al., 2013)
          EcR - alien
          pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
          (Huang et al., 2014, Dressel et al., 1999)
          EcR - ari-1
          anti tag coimmunoprecipitation, anti tag western blot, two hybrid, western blot, enzymatic study
          (Gradilla et al., 2011)
          EcR - bon
          pull down, anti tag western blot
          (Beckstead et al., 2001)
          EcR - cg
          proximity ligation assay
          (Hitrik et al., 2016)
          EcR - crc
          pull down, autoradiography, two hybrid
          (Gauthier et al., 2012)
          EcR - fru
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2018)
          EcR - kto
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - nej
          anti tag coimmunoprecipitation, anti tag western blot
          (Kirilly et al., 2011)
          EcR - rig
          pull down, autoradiography, anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015, Gates et al., 2004)
          EcR - skd
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - svp
          two hybrid
          (Zelhof et al., 1995)
          EcR - tai
          anti bait coimmunoprecipitation, Identification by mass spectrometry
          (Xie et al., 2015)
          EcR - trr
          anti bait coimmunoprecipitation, western blot
          (Pascual-Garcia et al., 2017)
          EcR - usp
          two hybrid, electrophoretic mobility shift assay, electrophoretic mobility supershift assay, autoradiography, bimolecular fluorescence complementation, fluorescence microscopy, anti bait coimmunoprecipitation, western blot, pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, anti tag western blot, x-ray crystallography, peptide massfingerprinting, experimental knowledge based
          (Kreher et al., 2017, Xie et al., 2015, Huang et al., 2014, Rhee et al., 2014, Bitra and Palli, 2009, Dutko-Gwóźdź et al., 2008, Li et al., 2007, Fang et al., 2005, Bergman et al., 2004, Maki et al., 2004, Przibilla et al., 2004, Devarakonda et al., 2003, Hu et al., 2003, Lezzi et al., 2002, Sutherland et al., 1995, Zelhof et al., 1995, Yao et al., 1993, Yao et al., 1992)
          EcR - yki
          coimmunoprecipitation, western blot
          (Zhang et al., 2015)
          RNA-protein
          Physical Interaction
          Assay
          References
          EcR - B52
          electrophoretic mobility shift assay, autoradiography, systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing
          (Kim et al., 2003)
          RNA-RNA
          Physical Interaction
          Assay
          References
          EcR - mir-14
          immunohistochemistry, luminiscence technology, necessary binding region, fluorescence technology, western blot
          (Varghese and Cohen, 2007)
          EcR - mir-34
          immunohistochemistry
          (Lai et al., 2016)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          EcR
          suppressible
          ab
          (Jang et al., 2009)
          EcR
          enhanceable
          Brms1
          (Song et al., 2013)
          EcR
          enhanceable
          crc
          (Gauthier et al., 2012)
          EcR
          suppressible
          crc
          (Gauthier et al., 2012)
          EcR
          suppressible
          Diap1
          (Lee et al., 2019)
          EcR
          enhanceable
          E(bx)
          (Badenhorst et al., 2005)
          EcR
          suppressible
          grim
          (Lee et al., 2019)
          EcR
          suppressible
          hdc
          (Loncle and Williams, 2012)
          EcR
          suppressible
          hid
          (Lee et al., 2019)
          EcR
          enhanceable
          Iswi
          (Badenhorst et al., 2005)
          EcR
          suppressible
          Mical
          (Kirilly et al., 2009)
          EcR
          suppressible
          mir-let7
          (Kucherenko et al., 2012)
          EcR
          enhanceable
          mys
          (Kozlova and Thummel, 2003)
          EcR
          enhanceable
          Nurf-38
          (Badenhorst et al., 2005)
          EcR
          suppressible
          Pten
          (Rusten et al., 2004)
          EcR
          suppressible
          rpr
          (Lee et al., 2019)
          EcR
          suppressible
          Smr
          (Sedkov et al., 2003, Sedkov et al., 2003)
          EcR
          suppressible
          Sox14
          (Kirilly et al., 2009)
          EcR
          suppressible
          trr
          (Sedkov et al., 2003, Sedkov et al., 2003)
          EcR
          enhanceable
          trr
          (Sedkov et al., 2003)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          ari-1
          suppressible
          EcR
          (Gradilla et al., 2011)
          Atg1
          suppressible
          EcR
          (Chen et al., 2008)
          babo
          suppressible
          EcR
          (Boulanger et al., 2011, Zheng et al., 2003)
          DENR
          suppressible
          EcR
          (Schleich et al., 2014)
          dom
          enhanceable
          EcR
          (Kwon et al., 2013)
          fru
          suppressible
          EcR
          (Goto et al., 2011)
          ftz-f1
          suppressible
          EcR
          (Boulanger et al., 2011)
          G9a
          enhanceable
          EcR
          (Kleefstra et al., 2012, Stabell et al., 2006)
          G9a
          suppressible
          EcR
          (Kleefstra et al., 2012)
          grim
          suppressible
          EcR
          (Liu et al., 2009)
          Hr39
          enhanceable
          EcR
          (Boulanger et al., 2011)
          Hr39|babo
          suppressible
          EcR
          (Boulanger et al., 2011)
          if
          enhanceable
          EcR
          (D'Avino and Thummel, 2000)
          Lam
          suppressible
          EcR
          (Osouda et al., 2005)
          LKRSDH
          suppressible
          EcR
          (Cakouros et al., 2008)
          mam
          enhanceable
          EcR
          (Kwon et al., 2013)
          mir-14
          suppressible
          EcR
          (Varghese and Cohen, 2007)
          mys
          enhanceable
          EcR
          (D'Avino and Thummel, 2000)
          Pax
          suppressible
          EcR
          (Chen et al., 2008)
          plum
          suppressible
          EcR
          (Yu et al., 2013)
          pzg
          suppressible
          EcR
          (Kugler et al., 2011)
          Rbf
          enhanceable
          EcR
          (Kwon et al., 2013)
          Set2
          enhanceable
          EcR
          (Stabell et al., 2007)
          SMC1
          enhanceable
          EcR
          (Schuldiner et al., 2008)
          SMC1
          suppressible
          EcR
          (Schuldiner et al., 2008)
          trr
          suppressible
          EcR
          (Sedkov et al., 2003)
          Usp7|bur
          enhanceable
          EcR
          (van der Knaap et al., 2010)
          Usp7|bur
          suppressible
          EcR
          (van der Knaap et al., 2010)
          Utx
          enhanceable
          EcR
          (Denton et al., 2013)
          External Data
          Subunit Structure (UniProtKB)
          Heterodimer of USP and ECR (PubMed:8247157). Only the heterodimer is capable of high-affinity binding to ecdysone (PubMed:8247157). Interacts with trr in an ecdysone-dependent manner (PubMed:14603321). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).
          (UniProt, P34021 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map

          2-55

          Cytogenetic map
          42A9-42A12
          Sequence location
          2R:6,087,873..6,169,087 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          42A9-42A12
          Limits computationally determined from genome sequence between P{lacW}l(2)k09848k09848&P{EP}EP407 and P{lacW}geminink14019&P{PZ}Adf101349
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          42A10-42A12
          (determined by in situ hybridisation) 42A1--19 (determined by in situ hybridisation)
          (Spradling et al., 1999)
          42A1-42A19
          42A1--2 42A10--12 42A10--16
          (BDGP Project Members, 1994-1999)
          42A-42A
          (determined by in situ hybridisation)
          (Koelle et al., 1991)
          Experimentally Determined Recombination Data
          Location

          2-55

          (FlyBase, 2016)

          2-55.8

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (81)
          Genomic Clones (61)
          cDNA Clones (198)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Kovalenko et al., 2019, Qian et al., 2014, Kirilly et al., 2011)

          monoclonal

          (Lanet et al., 2013, Schwedes et al., 2011, Talbot et al., 1993)

          monoclonal, polyclonal

          (Koelle et al., 1991)
          Commercially Available Antibodies
           
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: EcR CG1765

          (Kodira, 1999.11)
          Source for database merge of

          Source for merge of: snt EcR

          (Florence and McGinnis, 1998)

          Source for merge of: EcR CG8347

          (Levis, 2004.3.9)

          Source for merge of: EcR lie

          (Levis, 2004.3.9)

          Source for merge of: EcR anon-WO0229075.1

          (FlyBase, 1996-)
          Additional comments

          Source for merge of EcR anon-WO0229075.1 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Other Comments

          Ortholog of B. mori juvenile-hormone-related gene (involved in JH biosynthesis, metabolism or signaling).

          (Cheng et al., 2014)

          crc is an EcR receptor coactivator that is specific for the B2 isoform.

          (Gauthier et al., 2012)

          DNA-protein interactions: genome-wide binding profile assayed for EcR protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

          (Filion et al., 2010)

          The EcR-A isoform is not a signal transducer for programmed cell death in Crz-expressing ventral nerve cord neurons. EcR-B isoforms play significant roles in Crz-expressing ventral nerve cord neuron cell death.

          (Choi et al., 2006)

          dsRNA has been made from templates generated with primers directed against this gene. RNAi of EcR reduces the primary dendrite outgrowth of ddaD and ddaE neurons, but causes only modest reduction of lateral branching and lateral branch outgrowth. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

          (Parrish et al., 2006)

          ChEST reveals this is a target of Mef2.

          (Junion et al., 2005)

          Ecdysone signalling cell-autonomously downregulates PI3K activity in the fat body.

          (Rusten et al., 2004)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          babo/Smox mediated TGFΒ/Activin signalling mediates remodeling of mushroom body neurons via controlling EcR-B1 expression.

          (Zheng et al., 2003)

          EcR is not required for morphogenetic furrow formation in the developing eye.

          (Brennan et al., 2001)

          The EcR/usp heterodimer DNA binding activity requires activation by a chaperone heterocomplex of six proteins including the products of Hsp83 and the Hsc70 genes. The gene products of Hsp83 and the Hsc70 genes are also required in vivo for EcR activity and EcR is the primary target of the chaperone complex.

          (Arbeitman and Hogness, 2000)

          Genetic interaction between EcRE261st and Sin3Ak07401 reported in FBrf0111507 is not evident when EcRC300Y is combined with Sin3A08269, suggesting that the original observed interaction could be due to background effects.

          (Bodai, 2000.12.22)

          EcR function is required maternally for normal oogenesis.

          (Carney and Bender, 2000)

          EcR together with crol controls wing morphogenesis and cell adhesion by regulating integrin expression during metamorphosis.

          (D'Avino and Thummel, 2000)

          EcR has a cell autonomous role in controlling neuronal remodelling.

          (Lee et al., 2000)

          EcR is required for hatching, at each larval moult and for the initiation of metamorphosis.

          (Li and Bender, 2000)

          EcR/usp may play an essential role as a hormonal timer.

          (Brodu et al., 1999)

          The ng-EcRE, located within the coding region of ng1 and ng2, binds the EcR/usp heterodimer through its widely spaced half sites.

          (Crispi et al., 1998)

          Binding site selection procedure demonstrates that the EcR/usp heterodimer binds to the core recognition motif (consensus sequence consists of a perfect palindrome of the heptameric half-site sequence GAGGTCA that is separated by a single A/T base pair).

          (Vogtli et al., 1998)

          Mutations in EcR reveal functional differences among the receptor isoforms encoded by the EcR gene.

          (Bender et al., 1997)

          Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Mutants weakly interact with Pc.

          (Gellon et al., 1997)

          The EcR/usp heterodimer binds in vitro to direct repeats and these repeats can confer ecdysteroid responsiveness on minimal promoters in a cell transfection assay. The natural pseudopalindromic EcR/usp binding site in the Fbp1 enhancer is required to mediate a fat body-specific ecdysteroid response. The profound differences in structure between these two types of EcR/usp binding site do not dictate a spatial and temporal specificity of the transcriptional response they mediate.

          (Antoniewski et al., 1996)

          Interaction of the DNA binding domain with a 20-hydroxyecdysone palindromic response element from the promoter region of Hsp27 has been studied.

          (Rusin et al., 1996)

          DNA-blotting assay has identified a high affinity ecdysone receptor binding site within the ng1 and ng2 coding sequence. EMSA assay demonstrates the 93bp 'ng element' is able to bind an EcR/usp heterodimer and usp alone.

          (D'Avino et al., 1995)

          Expression throughout the onset of metamorphosis is not affected by Eip74EF mutations.

          (Fletcher and Thummel, 1995)

          EcR and usp interact as a dimer.

          (Horner et al., 1995)

          The usp product acts as an allosteric effector to enhance steroid binding by the EcR product. Under some conditions, DNA binding by EcR/usp product is highly steroid-dependent.

          (Hu et al., 1995)

          The EcR product binds to two sites, element I and element II, in the regulatory region of Sgs4. Element II appears to be of no importance for the expression of Sgs4 while element I is an ecdysone response element necessary, but not sufficient, for Sgs4 induction.

          (Lehmann and Korge, 1995)

          EcR has been stably transfected into CHO cells. Nuclear extracts from the line exhibit specific binding activity for the Hsp27 ecdysone response element in mobility shift analyses.

          (Yang et al., 1995)

          The in vitro characterisation of the EcR/usp binding site its ecdysone- dependent in vivo occupancy in different genetic backgrounds support the conclusion that the Fbp1 enhancer is a primary target of the EcR.

          (Antoniewski et al., 1994)

          Neurons show qualitative and quantitative changes in EcR expression during their life history and these differences correlate with distinct patterns of ecdysteroid response.

          (Truman et al., 1994)

          Ecdysteroid-regulated gene.

          (Andres et al., 1993)

          Postmeiotic differentiation defect.

          (Castrillon et al., 1993)

          The correlation of a unique pattern of ecdysone receptor isoform A expression in the CNS of the emerging adult with a particular steroid regulated cell death fate suggests that variations in the pattern of receptor isoform expression may serve as important switches during development.

          (Robinow et al., 1993)

          The ecdysone receptor gene encodes three receptor isoforms with common DNA and hormone binding domains but different N-terminal regions. Different isoforms predominate at different developmental stages that are marked by a pulse of ecdysone.

          (Talbot et al., 1993)

          Transient cotransfection experiments in HeLa cells demonstrated that EcR must heterodimerize with usp (the homolog of the mammalian retinoid X receptor) for DNA binding and transactivation. EcR/usp gene product DNA binding activity is unaffected by ecdysteroid and 9-cis-retinoic acid.

          (Thomas et al., 1993)

          EcR and usp native gene products co-localise on ecdysone-responsive loci. Physical associations in the presence and absence of ecdysone redefine the ecdysone receptor as a dynamic complex whose activity may be altered by combinatorial interactions among subunits and ligand.

          (Yao et al., 1993)

          EcR protein can function as a ligand-dependent transcription factor in mammalian cells.

          (Christopherson et al., 1992)

          Cotransfection of both usp and EcR is required to render cultured mammalian cells ecdysone responsive.

          (Yao et al., 1992)

          usp is a Drosophila partner of EcR. Together usp and EcR bind DNA in a highly cooperative pattern.

          (Yao et al., 1992)

          Identification: EcR was identified in a screen for members of the steroid receptor superfamily.

          (Koelle et al., 1991)

          The DNA binding properties of the ecdysone receptor protein have been defined. In vitro binding studies demonstrate that ecdysterone causes activation or repression of the receptor DNA binding domain via an irreversible change in conformation.

          (Luo et al., 1991)

          EcR binds as a dimer to an imperfect palindromic sequence (GGTTCAATGCACT) in the Hsp27 promoter region.

          (Ozyhar et al., 1991)

          The effect of pyridoxal 5'-phosphate on the binding of EcR from a nuclear extract to DNA-cellulose is studied: application inhibits EcR binding to DNA.

          (Ozyhar et al., 1990)

          A novel bromoacetly ecdysteroid IV reacts with partially purified EcR rapidly and almost quantitatively.

          (Strangmann-Diekmann et al., 1990)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 108 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (44)
          Reported As
          Symbol Synonym
          CG1765
          (Chiang et al., 2016, Hosono et al., 2015, Cheng et al., 2014, Howell et al., 2012, Sala et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Quinones-Coello, 2007, Fulton et al., 2001)
          CG8347
          (Luschnig, 2003.12.17)
          DEcR
          (Martinez et al., 1999)
          Dhr23
          DmEcR
          (Bitra and Palli, 2009, Lapenna et al., 2009, Dhadialla et al., 2007, Li et al., 2007, Dinan et al., 2001, Hoppe et al., 2000, Henrich and Brown, 1995)
          ECR
          (Sengupta et al., 2016, Fahrbach et al., 2012, Lv et al., 2012, Filion et al., 2010, Chen et al., 2008, Flatt et al., 2005, Escriva et al., 1997)
          ECR-C
          (Wood et al., 2011)
          EcR
          (Kohzaki et al., 2020, Banerjee et al., 2019, Boulan et al., 2019, Drummond-Barbosa, 2019, Gutierrez-Perez et al., 2019, Ke and Hsu, 2019, Lee et al., 2019, Leiblich et al., 2019, Meltzer et al., 2019, Moreno et al., 2019, Pahl et al., 2019, Shokri et al., 2019, Swevers, 2019, Toshniwal et al., 2019, Xu et al., 2019, Yoshinari et al., 2019, Zheng et al., 2019, Zhou et al., 2019, Zhu et al., 2019, Ameku et al., 2018, Baron et al., 2018, Bischof et al., 2018, Bohère et al., 2018, Bovier et al., 2018, Buhler et al., 2018, Gáliková and Klepsatel, 2018, Gene Disruption Project members, 2018-, Geronikolou et al., 2018, Jiang et al., 2018, Lee et al., 2018, Lehmann, 2018, Lim et al., 2018, Liu et al., 2018, Meiselman et al., 2018, Sharma et al., 2018, Zou et al., 2018, Ables and Drummond-Barbosa, 2017, Busto et al., 2017, Doe, 2017, He et al., 2017, Herzmann et al., 2017, Jia et al., 2017, Kang et al., 2017, Kreher et al., 2017, Manning et al., 2017, Mazina et al., 2017, Misra et al., 2017, Pascual-Garcia et al., 2017, Rohde et al., 2017, Takayanagi-Kiya et al., 2017, Tomita et al., 2017, Transgenic RNAi Project members, 2017-, Zheng et al., 2017, Brookheart and Duncan, 2016, Chiang et al., 2016, Clandinin and Owens, 2016-, Crocker et al., 2016, Danielsen et al., 2016, Faunes and Larraín, 2016, Gokhale et al., 2016, Guo et al., 2016, Hitrik et al., 2016, Kuleesha et al., 2016, Maistrenko et al., 2016, Niwa and Niwa, 2016, Saadin and Starz-Gaiano, 2016, van der Harst et al., 2016, Xiong et al., 2016, Zanet et al., 2016, Zheng et al., 2016, Ables et al., 2015, Albuquerque et al., 2015, Bornstein et al., 2015, Celniker and White, 2015.1.26, Duff et al., 2015, Gautam et al., 2015, Ge et al., 2015, Gene Disruption Project members, 2015-, Gilboa, 2015, Homem et al., 2015, Jaumouillé et al., 2015, Lengil et al., 2015, Lin et al., 2015, Loncle et al., 2015, Luo et al., 2015, Nagarkar-Jaiswal et al., 2015, Nicolson et al., 2015, Schertel et al., 2015, Sieber and Spradling, 2015, Sopko et al., 2015, Ugrankar et al., 2015, Van Bortle et al., 2015, Verma and Cohen, 2015, Verma and Tapadia, 2015, Xie et al., 2015, Yan et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Banreti et al., 2014, Bernardo et al., 2014, Bonnay et al., 2014, Boyle et al., 2014, Chanut-Delalande et al., 2014, Chen et al., 2014, Cheng et al., 2014, Claudius et al., 2014, Danielsen et al., 2014, Depetris-Chauvin et al., 2014, Domanitskaya et al., 2014, Homem et al., 2014, Huang et al., 2014, Ihry and Bashirullah, 2014, Issman-Zecharya and Schuldiner, 2014, Kim et al., 2014, Kumar et al., 2014, Liu et al., 2014, Mulakkal et al., 2014, Nelson et al., 2014, Rhee et al., 2014, Schleich et al., 2014, Shlyueva et al., 2014, Slattery et al., 2014, Stratoulias et al., 2014, Tan et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Yamamoto et al., 2014, Zhang et al., 2014, Chauhan et al., 2013, Corty and Freeman, 2013, Deng and Kerppola, 2013, Denton et al., 2013, Denton et al., 2013, Gallant, 2013, Hill et al., 2013, Huang et al., 2013, Hyun, 2013, Jones et al., 2013, Koyama et al., 2013, Kwon et al., 2013, Lee et al., 2013, Liu et al., 2013, Mishra et al., 2013, Potdar and Sheeba, 2013, Seliga et al., 2013, Song et al., 2013, Vanden Broeck et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Yu et al., 2013, Yu et al., 2013, Zhu et al., 2013, Zirin et al., 2013, Zotti et al., 2013, Bielska et al., 2012, Chauhan et al., 2012, Chawla and Sokol, 2012, De Geyter et al., 2012, Fichelson et al., 2012, Gangishetti et al., 2012, Ganter et al., 2012, Garcia et al., 2012, Gauthier et al., 2012, Howell et al., 2012, Ihry et al., 2012, Ishimoto et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jin et al., 2012, Kamoshida et al., 2012, Kleefstra et al., 2012, Kroeger et al., 2012, Kucherenko et al., 2012, Loncle and Williams, 2012, Mirth and Shingleton, 2012, Morris and Spradling, 2012, Mou et al., 2012, Pakula et al., 2012, Rodriguez et al., 2012, Schauer et al., 2012, Takaesu et al., 2012, Tarone et al., 2012, Wang et al., 2012, Yaniv et al., 2012, Zoglowek et al., 2012, Abruzzi et al., 2011, Awasaki et al., 2011, Awasaki et al., 2011, Belacortu et al., 2011, Betanska et al., 2011, Boulanger et al., 2011, Davis et al., 2011, Dubrovsky et al., 2011, Fay et al., 2011, Gáliková et al., 2011, Gancz et al., 2011, Goto et al., 2011, Gradilla et al., 2011, Han et al., 2011, Itoh et al., 2011, Johnston et al., 2011, Kirilly et al., 2011, Klusza and Deng, 2011, König et al., 2011, Kugler et al., 2011, Micchelli et al., 2011, Nègre et al., 2011, Rajan and Perrimon, 2011, Schauer et al., 2011, Schauer et al., 2011, Schwedes et al., 2011, Takemura and Adachi-Yamada, 2011, Toku et al., 2011, Tremmel et al., 2011, Tremmel et al., 2011, Wang et al., 2011, Winbush and Weeks, 2011, Ables and Drummond-Barbosa, 2010, Blanco et al., 2010, Bond et al., 2010, Chavoshi et al., 2010, Cook and Cook, 2010.10.13, Cook and Cook, 2010.10.13, Delanoue et al., 2010, Francis et al., 2010, Garbuzov and Tatar, 2010, Gautam and Tapadia, 2010, Hirsch et al., 2010, Ishimoto and Kitamoto, 2010, Krusiński et al., 2010, Liu et al., 2010, Mosallanejad et al., 2010, Rendina et al., 2010, Rewitz et al., 2010, Ritter and Beckstead, 2010, Sawatsubashi et al., 2010, Sinenko et al., 2010, Swaminathan et al., 2010, van der Knaap et al., 2010, Wang et al., 2010, Wang et al., 2010, Azoitei and Spindler-Barth, 2009, Baker and Russell, 2009, Beatty et al., 2009, Bernardi et al., 2009, Bernardo et al., 2009, Boyle and Berg, 2009, Braun et al., 2009, Brown and Truman, 2009, Chittaranjan et al., 2009, Dalton et al., 2009, Fagegaltier et al., 2009, Gauhar et al., 2009, Harada et al., 2009, Ishimoto et al., 2009, Jang et al., 2009, Kirilly et al., 2009, Lee et al., 2009, Lin et al., 2009, Lin et al., 2009, Liu et al., 2009, Maeder et al., 2009, Mirth et al., 2009, Mohseni et al., 2009, Ninov et al., 2009, Nocula-Ługowska et al., 2009, Okamoto et al., 2009, Pentek et al., 2009, Romani et al., 2009, Ruff et al., 2009, Saleh et al., 2009, Slaidina et al., 2009, Tricoire et al., 2009, Tricoire et al., 2009, Bernardo et al., 2008, Cakouros et al., 2008, Carrera et al., 2008, Chen et al., 2008, Chen et al., 2008, Costantino et al., 2008, Costantino et al., 2008, Dutko-Gwóźdź et al., 2008, Flatt et al., 2008, Hackney and Dobens, 2008, Hoopfer et al., 2008, Kimura et al., 2008, Liu and Lehmann, 2008, Mitchell et al., 2008, Ng, 2008, Pauli et al., 2008, Petruk et al., 2008, Schuldiner et al., 2008, Schwedes and Carney, 2008, Soin et al., 2008, Sprecher and Desplan, 2008, Sun et al., 2008, Sun et al., 2008, Weake et al., 2008, Zhao et al., 2008, Baker et al., 2007, Bashirullah et al., 2007, Beltran et al., 2007, Bernardi et al., 2007, Betanska et al., 2007, Christensen et al., 2007.10.29, Cronauer et al., 2007, Curtis et al., 2007, Ganter et al., 2007, Hackney et al., 2007, Hackney et al., 2007, Johnston et al., 2007, Kim et al., 2007, McBrayer et al., 2007, Monnier et al., 2007, Nagalakshmi et al., 2007, Necakov et al., 2007, Nieva et al., 2007, Ninov et al., 2007, Nurminsky, 2007, Quinones-Coello, 2007, Roesijadi et al., 2007, Romani et al., 2007, Roy et al., 2007, Shi et al., 2007, Stabell et al., 2007, Sun et al., 2007, Thummel, 2007.4, Varghese and Cohen, 2007, Yin et al., 2007, Zeitouni et al., 2007, Akdemir et al., 2006, Awasaki et al., 2006, Beatty et al., 2006, Dobryszycki et al., 2006, Hoopfer et al., 2006, Moorman et al., 2006, Palanker et al., 2006, Parrish et al., 2006, Petruk et al., 2006, Santos et al., 2006, Stabell et al., 2006, Takaesu et al., 2006, Tolhuis et al., 2006, Warren et al., 2006, Beckstead et al., 2005, Fang et al., 2005, King-Jones and Thummel, 2005, Liebl and Featherstone, 2005, Lovato et al., 2005, Orme and Leevers, 2005, Terashima and Bownes, 2005, Williams and Truman, 2005, Bergman et al., 2004, Grebe et al., 2004, Maki et al., 2004, Przibilla et al., 2004, Stanyon et al., 2004, Takeyama et al., 2004, Pile et al., 2002, Li and Cooper, 2001, de la Cruz et al., 2000)
          EcR-A
          (Lengil et al., 2015, Ou et al., 2008, Sung and Robinow, 2000, McNabb et al., 1997, Robinow et al., 1997)
          EcR-B
          (Lengil et al., 2015, Choi et al., 2006)
          EcR-B1
          (Latcheva et al., 2019, Stinchfield et al., 2019, Lai et al., 2016, Yaniv and Schuldiner, 2016, Lengil et al., 2015, Rumpf et al., 2014, Rallis et al., 2013, Boulanger et al., 2012, Boulanger et al., 2011, Pauli et al., 2010, Riddiford et al., 2010, Ou et al., 2008, Ting et al., 2007, Roman, 2004, Watts et al., 2003, Zheng et al., 2003, Zheng et al., 2003)
          EcR1b
          (Fischer et al., 2012)
          EcRA
          (Miller et al., 2012, Tarone et al., 2012)
          EcRB
          (Tarone et al., 2012)
          EcRB-1
          (Gibson and Schubiger, 2001)
          EcRB1
          (Yang et al., 2019, Neto et al., 2017, Chang et al., 2013, Miller et al., 2012, Hoopfer et al., 2008, Moorman et al., 2006, Moorman et al., 2006, Wang et al., 2006, Marin et al., 2005, Osouda et al., 2005)
          EcRC
          (Miller et al., 2012)
          EcdR
          (Ozyhar et al., 1991)
          Ecr
          (Junion et al., 2005)
          Ecr1B
          (Fischer et al., 2012)
          EcrB1
          (Puram and Bonni, 2013)
          NR1H1
          (King-Jones and Thummel, 2005, Nuclear Receptors Nomenclature Committee, 1999)
          USP
          (Denton et al., 2013)
          Usp
          (Lehmann, 2018, Faunes and Larraín, 2016)
          anon-WO0229075.1
          dECR
          (Laudet and Adelmant, 1995)
          dmEcR
          (Harada et al., 2009)
          ecr
          (Lee et al., 2019, Xu et al., 2016, Tiwari et al., 2015, Tissot and Stocker, 2000)
          lie
          (Fabrizio et al., 1998, BDGP Project Members, 1994-1999)
          ms(2)06410
          ms(2)42A
          (Spradling et al., 1999, Castrillon et al., 1993)
          snt
          (Gellon et al., 1997)
          Name Synonyms
          Ecdyson Receptor 1b
          (Fischer et al., 2012)
          Ecdysone Receptor
          (Xu et al., 2019, Nagarkar-Jaiswal et al., 2015, Koyama et al., 2013, Ishimoto et al., 2009, Hackney and Dobens, 2008, Hackney et al., 2007, Johnston et al., 2007, Farkas and Mechler, 2001)
          Ecdysone receptor
          (Meiselman et al., 2018, Tomita et al., 2017, Maistrenko et al., 2016, Xu et al., 2016, Hackney and Cherbas, 2014, Chauhan et al., 2012, Ganter et al., 2012, Fay et al., 2011, Nègre et al., 2011, Delanoue et al., 2010, Ishimoto and Kitamoto, 2010, Pankotai et al., 2010, Ritter and Beckstead, 2010, Sinenko et al., 2010, van der Knaap et al., 2010, Bernardi et al., 2009, Boyle and Berg, 2009, Jang et al., 2009, Saleh et al., 2009, Sprecher and Desplan, 2008, Sprecher and Desplan, 2008, Zhao et al., 2008, Arbouzova and McNeill, 2007, Bernardi et al., 2007, Roesijadi et al., 2007, Sun et al., 2007, Zeitouni et al., 2007, Willard et al., 2006)
          Ecdysone-R
          (Pichaud, 2014)
          ecdysone receptor
          (Mulakkal et al., 2014, Rhee et al., 2014, Chauhan et al., 2013, Corty and Freeman, 2013, Iliadi et al., 2012, Ishimoto et al., 2012, Mirth and Shingleton, 2012, Awasaki et al., 2011, Dubrovsky et al., 2011, Eliazer and Buszczak, 2011, Johnston et al., 2011, Jones and Grotewiel, 2011, Takemura and Adachi-Yamada, 2011, Tremmel et al., 2011, Turner et al., 2011, Sawatsubashi et al., 2010, Swaminathan et al., 2010, Baker and Russell, 2009, Beatty et al., 2009, Bitra and Palli, 2009, Braun et al., 2009, Brown and Truman, 2009, Chittaranjan et al., 2009, Lee et al., 2009, Lin et al., 2009, Okamoto et al., 2009, Ruff et al., 2009, Slaidina et al., 2009, Cakouros et al., 2008, Chen et al., 2008, Costantino et al., 2008, Flatt et al., 2008, Kimura et al., 2008, Koo et al., 2008, Schwedes and Carney, 2008, Sun et al., 2008, Curtis et al., 2007, Ganter et al., 2007, Nagalakshmi et al., 2007, Awasaki et al., 2006, Beatty et al., 2006, Dobryszycki et al., 2006, Kaeser and Emerson, 2006, Fang et al., 2005, Flatt et al., 2005, Terashima and Bownes, 2005, Williams and Truman, 2005, Maki et al., 2004, Starz-Gaiano and Montell, 2004, Takeyama et al., 2002, Bai et al., 2000, de la Cruz et al., 2000, Hoppe et al., 2000)
          ecdysone receptor complex
          (Wood et al., 2011)
          ecdysone-Receptor
          (Hitrik et al., 2016)
          ecdysteroid receptor
          (Schauer et al., 2012, Schauer et al., 2011, Nocula-Ługowska et al., 2009, Nieva et al., 2007)
          ecdysterone receptor
          (Roy et al., 2007)
          long island expressway
          (Fabrizio et al., 1998)
          male sterile(2)42A
          snaggletooth
          (Gellon et al., 1997)
          Secondary FlyBase IDs
          • FBgn0011242
          • FBgn0021762
          • FBgn0033064
          • FBgn0062534
          Datasets (1)
          Study focus (1)
          Experimental Role
          Project
          Project Type
          Title
          • transgene_used
          FBGSE22069
          Protein profiling reveals five principal chromatin types in Drosophila cells.
          References (876)