FlyBase Gene Report: Dmel\EcR

General Information

Symbol

Dmel\EcR

Species

D. melanogaster

Name

Ecdysone receptor

Annotation Symbol

CG1765

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000546

Gene Model Status

Current

Stock Availability

81 publicly available

Gene Summary

Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

EcR-B1, EcRB1, DmEcR, EcR-A, ecdysteroid receptor

Key Links

Genomic Location

Cytogenetic map

42A9-42A12

Sequence location

2R:6,087,873..6,169,087 [-]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:6087873..6169087

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (75 terms)

Molecular Function (15 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

enables DNA binding

inferred from direct assay

(Johnston et al., 2011)

contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964

(Zelhof et al., 1995)

enables DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from direct assay

(Koelle et al., 1991)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from direct assay

(Chanut-Delalande et al., 2014)

enables DNA-binding transcription factor binding

inferred from physical interaction with FLYBASE:alien; FB:FBgn0013746

(Dressel et al., 1999)

enables ecdysone binding

inferred from direct assay

(Yao et al., 1993, Koelle et al., 1991)

contributes_to nuclear receptor activity

inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964

(Zelhof et al., 1995)

enables nuclear receptor activity

inferred from direct assay

(Talbot et al., 1993, Koelle et al., 1991)

enables protein binding

inferred from physical interaction with FLYBASE:Utx; FB:FBgn0260749

(Denton et al., 2013)

inferred from physical interaction with FLYBASE:rig; FB:FBgn0250850

(Gates et al., 2004)

inferred from physical interaction with UniProtKB:Q9VCH5

(assigned by UniProt )

(Pascual-Garcia et al., 2017)

enables protein heterodimerization activity

inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964

(Zelhof et al., 1995)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from direct assay

(Denton et al., 2013)

enables transcription cis-regulatory region binding

inferred from direct assay

(Lehmann and Korge, 1995)

enables transcription coactivator binding

inferred from physical interaction with FLYBASE:crc; FB:FBgn0000370

(Gauthier et al., 2012)

enables transcription corepressor binding

inferred from physical interaction with FLYBASE:LKRSDH; FB:FBgn0286198

(Cakouros et al., 2008)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables DNA binding

non-traceable author statement

(Kozlova and Thummel, 2000)

enables nuclear receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

non-traceable author statement

(Maglich et al., 2001)

inferred from sequence or structural similarity with MGI:MGI:1352464

(FlyBase Curators, 2008-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

enables steroid binding

non-traceable author statement

(Kozlova and Thummel, 2000)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (53 terms)

Terms Based on Experimental Evidence (47 terms)

CV Term

Evidence

References

involved_in autophagy

inferred from mutant phenotype

(Rusten et al., 2004)

involved_in border follicle cell migration

inferred from mutant phenotype

(Jang et al., 2009, Medioni and Noselli, 2005, Bai et al., 2000)

involved_in cardiac muscle tissue development

inferred from mutant phenotype

(Monier et al., 2005)

involved_in cardioblast differentiation

inferred from mutant phenotype

(Monier et al., 2005)

involved_in cell adhesion

inferred from mutant phenotype

(D'Avino and Thummel, 2000)

involved_in chitin-based cuticle development

inferred from mutant phenotype

(Chanut-Delalande et al., 2014)

involved_in chitin-based embryonic cuticle biosynthetic process

inferred from mutant phenotype

(Kozlova and Thummel, 2003)

involved_in cholesterol homeostasis

inferred from mutant phenotype

(Danielsen et al., 2016)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Simon et al., 2003)

involved_in dorsal vessel heart proper cell fate commitment

inferred from mutant phenotype

(Monier et al., 2005)

involved_in ecdysis, chitin-based cuticle

inferred from mutant phenotype

(Li and Bender, 2000)

involved_in ecdysone receptor-mediated signaling pathway

inferred from mutant phenotype

(Varghese and Cohen, 2007, Li and Bender, 2000)

inferred from mutant phenotype

(assigned by UniProt )

(Okamoto et al., 2018)

involved_in epidermis development

inferred from mutant phenotype

(Ninov et al., 2007)

involved_in germ cell development

inferred from mutant phenotype

(König et al., 2011)

involved_in germ-band shortening

inferred from mutant phenotype

(Kozlova and Thummel, 2003)

involved_in hatching

inferred from mutant phenotype

(Li and Bender, 2000)

involved_in head involution

inferred from mutant phenotype

(Kozlova and Thummel, 2003)

involved_in histoblast morphogenesis

inferred from mutant phenotype

(Ninov et al., 2007)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(D'Avino and Thummel, 2000)

inferred from genetic interaction with FLYBASE:if; FB:FBgn0001250

(D'Avino and Thummel, 2000)

inferred from genetic interaction with FLYBASE:mys; FB:FBgn0004657

(D'Avino and Thummel, 2000)

involved_in larval central nervous system remodeling

inferred from mutant phenotype

(Brown and Truman, 2009, Brown et al., 2006)

involved_in larval development

inferred from mutant phenotype

(assigned by UniProt )

(Okamoto et al., 2018)

involved_in larval wandering behavior

inferred from mutant phenotype

(Davis et al., 2005)

involved_in long-term memory

inferred from mutant phenotype

(Ishimoto et al., 2009)

involved_in Malpighian tubule morphogenesis

inferred from mutant phenotype

(Gautam and Tapadia, 2010)

involved_in metamorphosis

inferred from mutant phenotype

(Li and Bender, 2000)

involved_in mushroom body development

inferred from mutant phenotype

(Kucherenko et al., 2012, Lin et al., 2009)

inferred from genetic interaction with FLYBASE:babo; FB:FBgn0011300

(Zheng et al., 2003)

inferred from genetic interaction with FLYBASE:Smox; FB:FBgn0025800

(Zheng et al., 2003)

involved_in negative regulation of gene expression

inferred from mutant phenotype

(Verma and Cohen, 2015)

involved_in neuron remodeling

inferred from mutant phenotype

(Lin et al., 2009, Roy et al., 2007, Brown et al., 2006, Awasaki and Ito, 2004, Lee et al., 2000)

involved_in oogenesis

inferred from mutant phenotype

(Carney and Bender, 2000)

involved_in peripheral nervous system development

inferred from mutant phenotype

(Schubiger et al., 2005)

involved_in phagocytosis, engulfment

inferred from mutant phenotype

(Tasdemir-Yilmaz and Freeman, 2014)

acts_upstream_of positive regulation of apoptotic process

inferred from mutant phenotype

(Sprecher and Desplan, 2008)

involved_in positive regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Ishimoto and Kitamoto, 2010)

involved_in positive regulation of neuron remodeling

inferred from mutant phenotype

(Wong et al., 2013)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Chanut-Delalande et al., 2014, Gauthier et al., 2012)

inferred from genetic interaction with FLYBASE:Sgs4; FB:FBgn0003374

(Lehmann and Korge, 1995)

involved_in positive regulation of transcription, DNA-templated

inferred from mutant phenotype

(Bernardi et al., 2009)

involved_in pupariation

inferred from mutant phenotype

(Davis et al., 2005, Li and Bender, 2000)

involved_in regulation of autophagy

inferred from mutant phenotype

(Liu et al., 2013)

involved_in regulation of cellular respiration

inferred from mutant phenotype

(Homem et al., 2014)

involved_in regulation of hemocyte proliferation

inferred from mutant phenotype

(Sinenko et al., 2010)

involved_in regulation of Malpighian tubule diameter

inferred from mutant phenotype

(Gautam and Tapadia, 2010)

involved_in regulation of neuron remodeling

inferred from mutant phenotype

(Loncle and Williams, 2012)

involved_in regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(D'Avino and Thummel, 2000)

involved_in response to cocaine

inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499

(Willard et al., 2006)

involved_in response to ecdysone

inferred from mutant phenotype

(Johnston et al., 2011)

involved_in salivary gland cell autophagic cell death

inferred from mutant phenotype

(Ihry and Bashirullah, 2014)

involved_in sperm individualization

inferred from mutant phenotype

(Fabrizio et al., 1998)

Terms Based on Predictions or Assertions (9 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in dendrite morphogenesis

non-traceable author statement

(Grueber and Jan, 2004)

involved_in ecdysone-mediated induction of salivary gland cell autophagic cell death

non-traceable author statement

(Buszczak and Segraves, 2000)

involved_in larval central nervous system remodeling

traceable author statement

(Tissot and Stocker, 2000)

involved_in negative regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of transcription, DNA-templated

traceable author statement

(Kozlova and Thummel, 2000)

involved_in oogenesis

non-traceable author statement

(Kozlova and Thummel, 2000)

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001182089

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of development, heterochronic

traceable author statement

(Thummel, 2001)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

part_of activator ecdysone receptor complex

inferred from direct assay

(Lehmann and Korge, 1995)

located_in cytoplasm

inferred from direct assay

(Brennan et al., 2001)

located_in dendrite

inferred from mutant phenotype

(Kuo et al., 2005)

part_of ecdysone receptor holocomplex

inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964

(Zelhof et al., 1995)

located_in nucleus

inferred from direct assay

(Johnston et al., 2011, Carney and Bender, 2000, Lehmann and Korge, 1995, Talbot et al., 1993, Koelle et al., 1991)

located_in polytene chromosome

inferred from direct assay

(assigned by UniProt )

(Carbonell et al., 2013)

part_of repressor ecdysone receptor complex

inferred from physical interaction with FLYBASE:alien; FB:FBgn0013746

(Dressel et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of ecdysone receptor holocomplex

traceable author statement

(Buszczak and Segraves, 2000)

located_in polytene chromosome

non-traceable author statement

(Kozlova and Thummel, 2000)

Gene Group (FlyBase)

NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the nuclear hormone receptor family. NR1 subfamily. (P34021)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NUCLEAR RECEPTOR (LIGAND-DEPENDENT) TRANSCRIPTION FACTORS -: Nuclear receptors (NR) are C4 zinc finger ligand-dependent DNA-binding transcription factors. Members of the NR superfamily are defined by the presence of a highly conserved DNA-binding domain and a less conserved C-terminal ligand-binding domain. (Adapted from FBrf0184203).

Protein Function (UniProtKB)

Receptor for ecdysone (PubMed:1913820, PubMed:30293839). Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839).

(UniProt, P34021)

Summary (Interactive Fly)

transcription factor - nuclear receptor - zinc finger - regulates molting cycles and oogenesis

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\EcR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P34021)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

EcR-RA

FBtr0086008

NM_165461

5108

849

EcR-RB

FBtr0086011

NM_165465

4092

878

EcR-RC

FBtr0086012

NM_165464

4984

669

EcR-RD

FBtr0086009

NM_165462

3740

849

EcR-RE

FBtr0086010

NM_165463

5233

849

EcR-RG

FBtr0302439

NM_001169590

8415

878

Additional Transcript Data and Comments

Reported size (kB)

6, 5, 4 (northern blot)

(Talbot et al., 1993)

6.0 (northern blot)

(Koelle et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

EcR-PA

FBpp0085349

91.2

849

7.71

FBpp0085352

93.9

878

6.88

FBpp0085353

73.3

669

6.76

NP_724459

AAM68347

EcR-PD

FBpp0085350

91.2

849

7.71

FBpp0085351

91.2

849

7.71

FBpp0291631

93.9

878

6.88

P34021

NP_001163061

ACZ94341

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

849 aa isoforms: EcR-PA, EcR-PD, EcR-PE

878 aa isoforms: EcR-PB, EcR-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

878, 849, 669 (aa); 105, 80 (kD)

(Talbot et al., 1993)

878 (aa); 105 (kD observed)

(Koelle et al., 1991)

Comments

alternatively spliced exon

(FlyBase, 1992-)

External Data

Subunit Structure (UniProtKB)

Heterodimer of USP and ECR (PubMed:8247157). Only the heterodimer is capable of high-affinity binding to ecdysone (PubMed:8247157). Interacts with trr in an ecdysone-dependent manner (PubMed:14603321). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).

(UniProt, P34021)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\EcR using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 6

Comment: reference states 0-3 hr AEL

(Talbot et al., 1993)

second instar larval stage

(Talbot et al., 1993)

wandering third instar larval stage

organism

(Talbot et al., 1993)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 6

organism

(Talbot et al., 1993)

embryonic stage 7 -- 17

Comment: reference states >=3 hr AEL

(Koelle et al., 1991)

embryonic stage 12 -- 17

organism

(Talbot et al., 1993)

larval stage -- adult stage

(Koelle et al., 1991)

first instar larval stage

(Talbot et al., 1993)

third instar larval stage

(Talbot et al., 1993)

wandering third instar larval stage

organism

(Ritter and Beckstead, 2010)

prepupal stage P1 -- pharate adult stage P9

organism

(Talbot et al., 1993)

prepupal stage P4 -- pupal stage P5

organism

(Ritter and Beckstead, 2010)

pupal stage

(Talbot et al., 1993)

Additional Descriptive Data

The temporal pattern of EcR RNA expression was carefully studied and related to times of ecdysone pulses. Peaks of the 5kb EcR-A RNA occur in mid-embryogenesis and early and late in pupation.

(Talbot et al., 1993)

The temporal pattern of EcR RNA expression was carefully studied and related to times of ecdysone pulses. The strongest peak of EcR-B1 RNA expression occurs in late third instar larvae. Smaller peaks are observed during late embryonic, late first and second instar larval, and mid pupal stages.

(Talbot et al., 1993)

The 6 kb EcR transcript is detected in all stages except for 0-3 hr embryos. Expression is most abundant in embryos and in late third instar larvae and early pupae, with highest levels seen in wandering third instar larvae.

(Koelle et al., 1991)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

(Talbot et al., 1993)

prepupal stage

midgut imaginal island

(Talbot et al., 1993)

epidermis

(Talbot et al., 1993)

embryonic/larval muscle system

(Talbot et al., 1993)

embryonic/larval midgut

(Talbot et al., 1993)

embryonic/larval tracheal section

(Talbot et al., 1993)

haltere disc

(Talbot et al., 1993)

imaginal disc

(Talbot et al., 1993)

foregut imaginal ring

(Talbot et al., 1993)

ventral thoracic disc

(Talbot et al., 1993)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

organism

(Johnston et al., 2011)

larval stage -- adult stage

adult CSD interneuron

(Roy et al., 2007)

third instar larval stage

Kenyon cell

• cell body

(Takaesu et al., 2012)

early third instar larval stage -- prepupal stage P2

embryonic/larval salivary gland

(Johnston et al., 2011)

prepupal stage P1

astrocyte-like glial cell

Comment: isoform specific

(Tasdemir-Yilmaz and Freeman, 2014)

pupal stage

adult mushroom body gamma-lobe

(Watts et al., 2003)

projection neuron | subset

(Marin et al., 2005)

pupal stage P5 -- pharate adult stage P15

neuron | subset

Comment: reference states >=12 hr APF

(Robinow et al., 1993)

ventral nerve cord | restricted

Comment: reference states >=12 hr APF

(Robinow et al., 1993)

adult stage | female

follicle cell

(Schwedes et al., 2011)

adult stage | male

male accessory gland

(Schwedes et al., 2011)

testis

(Schwedes et al., 2011)

seminal vesicle

(Schwedes et al., 2011)

ejaculatory bulb

(Schwedes et al., 2011)

ejaculatory duct

(Schwedes et al., 2011)

oogenesis

egg chamber | ubiquitous

(Jang et al., 2009)

oogenesis stage S9

centripetal follicle cell

Comment: isoform "B1"

(Jang et al., 2009)

stretch follicle cell

Comment: isoform "B1"

(Jang et al., 2009)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Talbot et al., 1993, Koelle et al., 1991)

organism

(Talbot et al., 1993)

first instar larval stage

(Koelle et al., 1991)

wandering third instar larval stage

organism

(Koelle et al., 1991)

prepupal stage

(Koelle et al., 1991)

pupal stage

(Talbot et al., 1993, Koelle et al., 1991)

adult stage

(Koelle et al., 1991)

ovary

(Carney and Bender, 2000)

adult stage & oogenesis

nurse cell

(Carney and Bender, 2000)

follicle cell

(Carney and Bender, 2000)

Additional Descriptive Data

At 0h APF, reticular neuropil associated glial cells (astrocyte-like cells) express "EcR-B1" (EcR-RB), but not "EcR-A" (EcR-RA, EcR-RD) <up>isoform identities obtained from UniProt</up>.

(Tasdemir-Yilmaz and Freeman, 2014)

EcR staining is widespread in the adult brain.

(Ishimoto et al., 2009)

EcR isoform "A" is uniformly distributed in egg chambers at all stages. Isoform "B1" is more highly expressed in follicle cells than germline cells and shows a fourfold enrichment in anterior follicle cells at early oogenesis stage S9. The enrichment is reduced by mid stage 9 and absent by stage 10.

(Jang et al., 2009)

EcR is expressed in approximately 20 antennal lobe projection neurons, 18 of which are located in a anterodorsal cluster.

(Marin et al., 2005)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of activator ecdysone receptor complex

inferred from direct assay

(Lehmann and Korge, 1995)

located_in cytoplasm

inferred from direct assay

(Brennan et al., 2001)

located_in dendrite

inferred from mutant phenotype

(Kuo et al., 2005)

part_of ecdysone receptor holocomplex

inferred from physical interaction with FLYBASE:usp; FB:FBgn0003964

(Zelhof et al., 1995)

located_in nucleus

inferred from direct assay

(Johnston et al., 2011, Carney and Bender, 2000, Lehmann and Korge, 1995, Talbot et al., 1993, Koelle et al., 1991)

located_in polytene chromosome

inferred from direct assay

(assigned by UniProt )

(Carbonell et al., 2013)

part_of repressor ecdysone receptor complex

inferred from physical interaction with FLYBASE:alien; FB:FBgn0013746

(Dressel et al., 1999)

Expression Deduced from Reporters

Reporter: P{EcR.GET-BD-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval neuron | subset

(Kester and Nambu, 2011)

imaginal disc

(Kester and Nambu, 2011)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\EcR in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\EcR

View exonic expression by tissue for Dmel\EcR

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000546

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35540/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000546

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000546

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000546

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1765

Flygut - An atlas of the Drosophila adult midgut

FBgn0000546

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 114 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 49 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of EcR

Transgenic constructs containing regulatory region of EcR

Aberrations (Deficiencies and Duplications) ( 15 )

Inferred from experimentation ( 15 )

Gene disrupted in

Gene not disrupted in

Df(2R)cn88b

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)M41A4

(BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^A9

EcR^{B1-ΔC655.W650A.UAS}

lethal, with Scer\GAL4^Act5C.PI

lethal, with Scer\GAL4^dpp.blk1

EcR^{B1-ΔC655.F645A.UAS}

lethal, with Scer\GAL4^GMR71G10, Spyo\Cas9^UAS.P2

lethal, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

lethal, with Scer\GAL4^GMR.PF

lethal, with Scer\GAL4^Lsp2.PH

EcR^{B1-ΔC655.F645A.UAS}

lethal, with Scer\GAL4^MsrA.602

EcR^{B1-ΔC655.F645A.UAS}

lethal, with Scer\GAL4^phm.PU

EcR^{dsRNA.UAS.cCa}

lethal, with Scer\GAL4^ple.PF

EcR^GD1428

lethal, with Scer\GAL4^pnr-MD237

EcR^GD1428

lethal, with Scer\GAL4^Ser.PGF

EcR^{B1-ΔC655.F645A.UAS}

lethal, with Spyo\Cas9^{UAS.Tag:NLS(Unk)}

lethal (with Df(2R)ED1482)

EcR³¹

lethal (with Df(2R)ED1552)

EcR^Q50st

lethal (with EcR³¹)

EcR⁹⁹

lethal (with EcR⁹⁹)

EcR³¹

lethal (with EcR¹¹²)

EcR^M554fs

lethal (with EcR¹³⁹)

EcR^M554fs

lethal (with EcR^M554fs)

lethal | embryonic stage

EcR^{B1-ΔC655.F645A.UAS}

lethal | embryonic stage, with Scer\GAL4^69B

EcR^{B1-ΔC655.F645A.UAS}

lethal | embryonic stage, with Scer\GAL4^c381

EcR^{B1-ΔC655.F645A.UAS}

lethal | heat sensitive

lethal | heat sensitive, with Scer\GAL4^dpp.blk1

EcR^{B1-ΔC655.F645A.UAS}

lethal | heat sensitive (with EcR^A483T)

EcR^NP5219

lethal | heat sensitive (with EcR^NP5219)

EcR^A483T

lethal | larval stage

EcR^{B1-ΔC655.F645A.UAS}

lethal | larval stage, with Scer\GAL4^69B

EcR^{B1-ΔC655.F645A.UAS}

lethal | larval stage, with Scer\GAL4^c381

EcR^{B1-ΔC655.F645A.UAS}

lethal | nutrition conditional, with Scer\GAL4^r4

EcR^GD1428

lethal | pharate adult stage (with EcR¹¹²)

EcR^M554fs

lethal | pharate adult stage (with EcR^M554fs)

EcR¹¹²

lethal | pupal stage, with Scer\GAL4^pnr-MD237

EcR^GD1428

lethal | pupal stage (with EcR¹¹²)

EcR^M554fs

lethal | pupal stage (with EcR¹³⁹)

EcR^M554fs

lethal | pupal stage (with EcR^M554fs)

lethal | recessive

lethal | recessive | heat sensitive

lethal | second instar larval stage (with EcR¹⁷²)

EcR^M554fs

lethal | second instar larval stage (with EcR^M554fs)

EcR¹⁷²

lethal | third instar larval stage (with EcR⁹⁴)

EcR^M554fs

lethal | third instar larval stage (with EcR^M554fs)

EcR⁹⁴

lethal - all die before end of first instar larval stage, with Scer\GAL4^C57

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die before end of first instar larval stage, with Scer\GAL4^tsh-c724

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die before end of larval stage

EcR^dsRNA.hs.PL

lethal - all die before end of larval stage, with Scer\GAL4^c649

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die before end of larval stage, with Scer\GAL4^RapGAP1-OK6

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die before end of larval stage (with EcR⁹⁴)

EcR^M554fs

lethal - all die before end of larval stage (with EcR^M554fs)

EcR⁹⁴

lethal - all die before end of larval stage | heat sensitive

EcR^GAL4::LBD.hs

lethal - all die before end of larval stage | recessive

lethal - all die before end of prepupal stage | heat sensitive

EcR^dsRNA.hs.PL

lethal - all die before end of P-stage, with Scer\GAL4^da.G32

EcR^dsRNA.A.UAS

lethal - all die before end of P-stage, with Scer\GAL4^repo

lethal - all die before end of pupal stage, with Scer\GAL4^GMR.PF

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die before end of pupal stage, with Scer\GAL4^Mhc.PW

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die before end of pupal stage, with Scer\GAL4^Tab2-201Y

lethal - all die during embryonic stage

EcR^M554fs

lethal - all die during embryonic stage, with Scer\GAL4^arm.PS

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die during embryonic stage, with Scer\GAL4^Tub.PU

EcR^{B1-ΔC655.W650A.UAS}

lethal - all die during embryonic stage (with EcR⁵²)

EcR^M554fs

lethal - all die during embryonic stage (with EcR¹²⁰)

lethal - all die during embryonic stage (with EcR^M554fs)

lethal - all die during embryonic stage (with EcR^V559fs)

EcR^M554fs

lethal - all die during embryonic stage (with EcR^W53st)

EcR¹²⁰

lethal - all die during embryonic stage | heat sensitive

EcR^GAL4::LBD.hs

lethal - all die during embryonic stage | heat sensitive, with EcR^GAL4::LBD.hs

EcR^M554fs

lethal - all die during embryonic stage | heat sensitive, with EcR^M554fs

EcR^GAL4::LBD.hs

lethal - all die during embryonic stage | heat sensitive, with Scer\GAL4^hs.PB

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die during embryonic stage | recessive

lethal - all die during first instar larval stage, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

lethal - all die during larval stage, with Scer\GAL4^r4

EcR^{B1-ΔC655.W650A.UAS}

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

EcR^GD1428

partially lethal, with Scer\GAL4^en-e16E

partially lethal | heat sensitive

EcR^A.hs

partially lethal - majority die, with Scer\GAL4^phm.PU

EcR^A.UAS

partially lethal - majority die (with EcR¹¹)

partially lethal - majority die (with EcR³¹)

EcR⁹⁹

partially lethal - majority die (with EcR⁹⁹)

EcR³¹

partially lethal - majority die (with EcR^M554fs)

EcR¹¹

partially lethal - majority die (with EcR^W53st)

EcR¹¹

partially lethal - majority die | first instar larval stage (with EcR¹⁷²)

EcR^M554fs

partially lethal - majority die | first instar larval stage (with EcR^M554fs)

EcR¹⁷²

partially lethal - majority die | pharate adult stage (with EcR¹³⁹)

EcR^M554fs

partially lethal - majority die | pharate adult stage (with EcR^M554fs)

EcR¹³⁹

partially lethal - majority die | pharate adult stage | recessive

EcR^k06210

partially lethal - majority die | prepupal stage (with EcR¹¹²)

EcR^M554fs

partially lethal - majority die | prepupal stage (with EcR^M554fs)

EcR¹¹²

partially lethal - majority die | pupal stage (with EcR¹¹²)

EcR^M554fs

partially lethal - majority die | pupal stage (with EcR¹³⁹)

EcR^M554fs

partially lethal - majority die | pupal stage (with EcR^M554fs)

partially lethal - majority die | recessive

EcR⁰⁶⁴¹⁰

partially lethal - majority die | second instar larval stage (with EcR⁹⁴)

EcR^M554fs

partially lethal - majority die | second instar larval stage (with EcR¹¹²)

EcR^M554fs

partially lethal - majority die | second instar larval stage (with EcR¹³⁹)

EcR^M554fs

partially lethal - majority die | second instar larval stage (with EcR^M554fs)

partially lethal - majority die | third instar larval stage (with EcR¹¹²)

EcR^M554fs

partially lethal - majority die | third instar larval stage (with EcR¹³⁹)

EcR^M554fs

partially lethal - majority die | third instar larval stage (with EcR^M554fs)

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

EcR^GD1428

viable, with Scer\GAL4^ey-OK107

EcR^{B1-ΔC655.W650A.UAS}

viable, with Scer\GAL4^GMR71G10, Spyo\Cas9^UAS.P2

EcR^gRNA.pCFD3-3

viable, with Scer\GAL4^Sgs3.PD

EcR^{B1-ΔC655.F645A.UAS}

viable, with Scer\GAL4^tin.CΔ4

EcR^GD1428

viable | somatic clone, with Scer\GAL4^byn-Gal4

EcR^{B1-ΔC655.F645A.UAS}

Sterility

Allele

female sterile, with Scer\GAL4^slbo.2.6

EcR^{B1-ΔC655.F645A.UAS}

female sterile | recessive | heat sensitive

male fertile, with Scer\GAL4^nos.PG

male sterile

EcR⁰⁶⁴¹⁰

male sterile | recessive

EcR⁰⁶⁴¹⁰

Other Phenotypes

Allele

abnormal body size | larval stage, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

abnormal cell death

EcR^dsRNA.hs.PL

abnormal cell migration | pupal stage, with Scer\GAL4^Cg.PA

EcR^{dsRNA.UAS.cCa}

abnormal cell shape | somatic clone, with Scer\GAL4^e22c

EcR^{B1-ΔC655.W650A.UAS}

abnormal circadian rhythm, with Scer\GAL4^P2.4.Pdf

EcR^NIG.1765R

abnormal courtship behavior | conditional | dominant

abnormal courtship behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

EcR^{dsRNA.UAS.cIa}

abnormal courtship behavior | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

EcR^{dsRNA.UAS.cIa}

abnormal developmental rate, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

abnormal developmental rate, with Scer\GAL4^c649

EcR^{B1-ΔC655.F645A.UAS}

abnormal developmental rate, with Scer\GAL4^Lsp2.PH

EcR^{B1-ΔC655.W650A.UAS}

abnormal developmental rate | pupal stage (with EcR¹¹²)

EcR^M554fs

abnormal developmental rate | pupal stage (with EcR¹³⁹)

EcR^M554fs

abnormal developmental rate | pupal stage (with EcR^M554fs)

abnormal feeding behavior | third instar larval stage (with EcR¹¹²)

EcR^M554fs

abnormal feeding behavior | third instar larval stage (with EcR¹³⁹)

EcR^M554fs

abnormal feeding behavior | third instar larval stage (with EcR^M554fs)

abnormal locomotor behavior, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

abnormal locomotor behavior | adult stage | dominant

EcR^V559fs

abnormal locomotor behavior | third instar larval stage (with EcR¹¹²)

EcR^M554fs

abnormal locomotor behavior | third instar larval stage (with EcR¹³⁹)

EcR^M554fs

abnormal locomotor behavior | third instar larval stage (with EcR^M554fs)

abnormal memory | dominant

abnormal memory | dominant | heat sensitive

EcR^A483T

abnormal memory | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

EcR^{dsRNA.UAS.cIa}

abnormal memory | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

EcR^{dsRNA.UAS.cIa}

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^109(2)80

abnormal neuroanatomy, with Scer\GAL4^alrm.PD

abnormal neuroanatomy, with Scer\GAL4^c739

EcR^{dsRNA.UAS.cCa}

abnormal neuroanatomy, with Scer\GAL4^FMRFa.PS

abnormal neuroanatomy, with Scer\GAL4^let7C

EcR^{dsRNA.UAS.cCa}

abnormal neuroanatomy, with Scer\GAL4^Mhc.PW

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

abnormal neuroanatomy, with Scer\GAL4^Tab2-201Y

EcR^{dsRNA.UAS.cCa}

abnormal neuroanatomy, with Scer\GAL4^αTub84B.PP

EcR^{B1-ΔC655.W650A.UAS}

abnormal neuroanatomy (with EcR³¹)

EcR⁹⁹

abnormal neuroanatomy (with EcR⁹⁹)

EcR³¹

abnormal neuroanatomy | adult stage, with Scer\GAL4^ey-OK107

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR71G10

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^UAS.P2

EcR^gRNA.pCFD3-3

abnormal neuroanatomy | early third instar larval stage, with Scer\GAL4^CCAP.PP

EcR^{B1-ΔC655.W650A.UAS}

abnormal neuroanatomy | larval stage, with Scer\GAL4^RapGAP1-OK6

EcR^{B1-ΔC655.F645A.UAS}

abnormal neuroanatomy | P-stage, with Scer\GAL4^ppk.PU

EcR^{B1-ΔC655.W650A.UAS}

abnormal neuroanatomy | pupal stage, with Scer\GAL4^Crz.PU

EcR^{B1-ΔC655.W650A.UAS}

abnormal neuroanatomy | pupal stage, with Scer\GAL4^lilli-189Y

EcR^{B1-ΔC655.F645A.UAS}

abnormal neuroanatomy | pupal stage, with Scer\GAL4^NP3056

EcR^{B1-ΔC655.F645A.UAS}

abnormal neuroanatomy | pupal stage, with Scer\GAL4^orb-0449-G4

EcR^{B1-ΔC655.F645A.UAS}

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.PG

EcR^{B1-ΔC655.F645A.UAS}

abnormal neuroanatomy | pupal stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

abnormal neuroanatomy | pupal stage (with EcR¹¹²)

EcR^M554fs

abnormal neuroanatomy | pupal stage (with EcR¹³⁹)

EcR^M554fs

abnormal neuroanatomy | pupal stage (with EcR^M554fs)

abnormal neuroanatomy | second instar larval stage, with Scer\GAL4^CCAP.PP

EcR^{B1-ΔC655.W650A.UAS}

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Burs.PL

EcR^{B1-ΔC655.W650A.UAS}

abnormal neuroanatomy | wandering third instar larval stage, with Scer\GAL4^CCAP.PP

abnormal size, with Scer\GAL4^ey-OK107

EcR^miRNA.UAS

abnormal size | pupal stage, with Scer\GAL4^CCAP.PP

abnormal size | pupal stage (with EcR¹¹²)

EcR^M554fs

abnormal size | pupal stage (with EcR¹³⁹)

EcR^M554fs

abnormal size | pupal stage (with EcR^M554fs)

abnormal sleep, with Scer\GAL4^{Mef2.247.Switch}

abnormal sleep | dominant

abnormal sleep | heat sensitive (with EcR^A483T)

EcR^NP5219

abnormal sleep | heat sensitive (with EcR^NP5219)

EcR^A483T

decreased body size | larval stage, with Scer\GAL4^c649

EcR^{B1-ΔC655.F645A.UAS}

decreased body size | larval stage, with Scer\GAL4^tsh-c724

EcR^{B1-ΔC655.F645A.UAS}

decreased body size | pupal stage, with Scer\GAL4^fkh.PH

EcR^TH01841.N

decreased cell death, with Scer\GAL4^Crz.PC

decreased cell death (with EcR³¹)

EcR⁹⁹

decreased cell death (with EcR⁹⁹)

EcR³¹

decreased cell death | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

EcR^{B1-ΔC655.F645A.UAS}

decreased cell death | pupal stage, with Scer\GAL4^Crz.PU

EcR^{B1-ΔC655.W650A.UAS}

decreased cell number | larval stage, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

decreased cell number | third instar larval stage (with EcR³¹)

EcR⁹⁹

decreased cell number | third instar larval stage (with EcR⁹⁹)

EcR³¹

decreased cell size | cell autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

EcR^{dsRNA.UAS.cCa}

decreased cell size | somatic clone, with Scer\GAL4^e22c

EcR^{B1-ΔC655.W650A.UAS}

decreased cell size | third instar larval stage, with Scer\GAL4^fkh.PH

EcR^{dsRNA.UAS.cCa}

decreased fecundity | female (with EcR^A483T)

decreased fecundity | female (with EcR^M554fs)

EcR^A483T

decreased fecundity | female (with EcR^R344Q)

EcR^A483T

decreased fecundity | female (with EcR^V559fs)

EcR^A483T

decreased fecundity | female | RU486 conditional, with Scer\GAL4^da.Switch.PT

EcR^{dsRNA.UAS.cCa}

decreased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

EcR^{A-ΔC655.F645A.UAS}

decreased occurrence of cell division | third instar larval stage, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

decreased occurrence of cell division | third instar larval stage (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

decreased occurrence of cell division | third instar larval stage (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

increased cell death | early third instar larval stage, with Scer\GAL4^CCAP.PP

EcR^{B1-ΔC655.W650A.UAS}

increased cell death | second instar larval stage, with Scer\GAL4^CCAP.PP

EcR^{B1-ΔC655.W650A.UAS}

increased cell death | third instar larval stage, with Scer\GAL4^Burs.PL

EcR^{B1-ΔC655.W650A.UAS}

increased cell death | wandering third instar larval stage, with Scer\GAL4^CCAP.PP

increased fecundity | dominant | female

EcR^V559fs

increased size | adult stage, with Scer\GAL4^byn-Gal4

EcR^{B1-ΔC655.F645A.UAS}

long lived

EcR^A483T

long lived | dominant

long lived | male | RU486 conditional, with Scer\GAL4^Switch1.106

EcR^{dsRNA.UAS.cCa}

long lived | RU486 conditional, with Scer\GAL4^da.Switch.PT

majority die during larval stage (with EcR¹¹²)

EcR^M554fs

majority die during larval stage (with EcR¹³⁹)

EcR^M554fs

majority die during larval stage (with EcR^M554fs)

melanotic mass phenotype | larval stage, with Scer\GAL4^A9

EcR^{B1-ΔC655.W650A.UAS}

short lived, with Scer\GAL4^byn-Gal4

EcR^{B1-ΔC655.F645A.UAS}

short lived | female | RU486 conditional, with Scer\GAL4^da.Switch.PT

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

EcR^GD1428

short lived | RU486 conditional, with Scer\GAL4^da.Switch.PT

some die during embryonic stage

EcR^M554fs

some die during embryonic stage, with Scer\GAL4^arm.PS

EcR^{B1-ΔC655.F645A.UAS}

some die during embryonic stage (with EcR⁵²)

EcR^M554fs

some die during embryonic stage (with EcR¹²⁰)

some die during embryonic stage (with EcR^M554fs)

some die during embryonic stage (with EcR^V559fs)

EcR^M554fs

some die during embryonic stage (with EcR^W53st)

EcR¹²⁰

some die during embryonic stage | heat sensitive

EcR^GAL4::LBD.hs

some die during embryonic stage | heat sensitive, with EcR^GAL4::LBD.hs

EcR^M554fs

some die during embryonic stage | heat sensitive, with EcR^M554fs

EcR^GAL4::LBD.hs

some die during embryonic stage | heat sensitive, with Scer\GAL4^hs.PB

EcR^{B1-ΔC655.F645A.UAS}

some die during embryonic stage | recessive

some die during first instar larval stage, with Scer\GAL4^C57

EcR^{B1-ΔC655.F645A.UAS}

some die during first instar larval stage, with Scer\GAL4^tsh-c724

EcR^{B1-ΔC655.F645A.UAS}

some die during larval stage

EcR^dsRNA.hs.PL

some die during larval stage, with Scer\GAL4^A9

EcR^{B1-ΔC655.W650A.UAS}

some die during larval stage, with Scer\GAL4^c649

EcR^{B1-ΔC655.F645A.UAS}

some die during larval stage, with Scer\GAL4^RapGAP1-OK6

EcR^{B1-ΔC655.F645A.UAS}

some die during larval stage (with EcR³¹)

EcR⁹⁹

some die during larval stage (with EcR⁹⁹)

EcR³¹

some die during larval stage | heat sensitive

EcR^GAL4::LBD.hs

some die during larval stage | recessive

some die during pharate adult stage, with Scer\GAL4^da.G32

EcR^dsRNA.A.UAS

some die during pharate adult stage, with Scer\GAL4^repo

some die during prepupal stage | recessive (with EcR¹¹²)

EcR^M554fs

some die during prepupal stage | recessive (with EcR¹³⁹)

EcR^M554fs

some die during prepupal stage | recessive (with EcR^M554fs)

some die during prepupal stage | recessive | heat sensitive

EcR^dsRNA.hs.PL

some die during pupal stage, with Scer\GAL4^A9

EcR^{B1-ΔC655.W650A.UAS}

some die during pupal stage, with Scer\GAL4^GMR.PF

EcR^{B1-ΔC655.F645A.UAS}

some die during pupal stage, with Scer\GAL4^Mhc.PW

EcR^{B1-ΔC655.F645A.UAS}

some die during pupal stage, with Scer\GAL4^Tab2-201Y

some die during pupal stage (with EcR¹¹)

some die during pupal stage (with EcR¹¹²)

EcR^M554fs

some die during pupal stage (with EcR¹³⁹)

EcR^M554fs

some die during pupal stage (with EcR^M554fs)

some die during pupal stage (with EcR^W53st)

EcR¹¹

some die during third instar larval stage (with EcR⁹⁴)

EcR^M554fs

some die during third instar larval stage (with EcR^M554fs)

EcR⁹⁴

visible, with Scer\GAL4^Bx-MS1096

visible, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

visible, with Scer\GAL4^GMR.PU

EcR^{dsRNA.UAS.cCa}

visible | pupal stage, with Scer\GAL4^CCAP.PP

visible | recessive | somatic clone

EcR^M554fs

Phenotype manifest in

Allele

adult brain (with EcR³¹)

EcR^W53st

adult brain (with EcR^W53st)

EcR³¹

adult CSD interneuron, with Scer\GAL4^αTub84B.PP

EcR^{B1-ΔC655.W650A.UAS}

adult heart ventral longitudinal muscle cell, with Scer\GAL4^org-1.HN39

EcR^{DN.UAS.B1.cUa}

adult midgut

EcR^dsRNA.hs.PL

adult mushroom body, with Scer\GAL4^ey-OK107

adult mushroom body (with EcR³¹)

EcR^W53st

adult mushroom body (with EcR^W53st)

EcR³¹

adult mushroom body beta-lobe

adult mushroom body beta-lobe, with Scer\GAL4^c739

EcR^{dsRNA.UAS.cCa}

adult mushroom body beta-lobe, with Scer\GAL4^let7C

EcR^{dsRNA.UAS.cCa}

adult mushroom body gamma-lobe | adult stage, with Scer\GAL4^ey-OK107

EcR^miRNA.UAS

adult pylorus, with Scer\GAL4^byn-Gal4

EcR^{B1-ΔC655.F645A.UAS}

amnioserosa, with Scer\GAL4^da.G32

EcR^{B1-ΔC655.W650A.UAS}

anterior crossvein | ectopic

EcR^k06210

anterior pupal spiracle (with EcR⁹⁴)

EcR^M554fs

anterior pupal spiracle (with EcR^M554fs)

EcR⁹⁴

astrocyte-like glial cell, with Scer\GAL4^alrm.PD

astrocyte-like glial cell | somatic clone, with Scer\GAL4^alrm.PD

autolysosome, with Scer\GAL4^Lsp2.PH

EcR^{B1-ΔC655.W650A.UAS}

autophagosome, with Scer\GAL4^Lsp2.PH

axon | adult stage, with Scer\GAL4^GMR71G10

axon | adult stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^UAS.P2

EcR^gRNA.pCFD3-3

border follicle cell, with Scer\GAL4^slbo.2.6

cephalopharyngeal skeleton, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

cephalopharyngeal skeleton, with Scer\GAL4^69B

EcR^{B1-ΔC655.W650A.UAS}

cephalopharyngeal skeleton (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

cephalopharyngeal skeleton (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

dendrite, with Scer\GAL4^109(2)80

dendrite, with Scer\GAL4^ppk.1.9

dendrite, with Scer\GAL4^Tab2-201Y

EcR^{dsRNA.UAS.cCa}

dendritic arborizing neuron | P-stage, with Scer\GAL4^ppk.PG

EcR^{B1-ΔC655.F645A.UAS}

dendritic tree | P-stage, with Scer\GAL4^ppk.PU

EcR^{B1-ΔC655.W650A.UAS}

denticle belt, with Scer\GAL4^69B

EcR^{B1-ΔC655.W650A.UAS}

dorsal appendage, with Scer\GAL4^slbo.2.6

EcR^{B1-ΔC655.F645A.UAS}

dorsal appendage | maternal effect, with Scer\GAL4^slbo.2.6

EcR^{B1-ΔC655.F645A.UAS}

dorsal pouch

EcR³¹⁸

egg chamber

EcR^A483T

egg chamber | germline clone

EcR^M554fs

egg chamber | heat sensitive

egg chorion, with Scer\GAL4^slbo.2.6

EcR^{B1-ΔC655.F645A.UAS}

egg operculum, with Scer\GAL4^slbo.2.6

EcR^{B1-ΔC655.F645A.UAS}

embryo | dorsal closure stage

embryo | dorsal closure stage, with Scer\GAL4^69B

EcR^{B1-ΔC655.W650A.UAS}

embryo | dorsal closure stage, with Scer\GAL4^hs.PB

EcR^{B1-ΔC655.F645A.UAS}

embryo | embryonic stage 14

EcR^M554fs

embryo | embryonic stage 14, with Scer\GAL4^69B

EcR^{B1-ΔC655.W650A.UAS}

embryonic/first instar larval cuticle

EcR^GAL4::LBD.hs

embryonic/first instar larval cuticle, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

embryonic/first instar larval cuticle, with Scer\GAL4^hs.PB

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval adipose system, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval cuticle, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

embryonic/larval cuticle (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

embryonic/larval cuticle (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

embryonic/larval digestive system | larval stage, with Scer\GAL4^A9

EcR^{B1-ΔC655.W650A.UAS}

embryonic/larval epidermis, with Scer\GAL4^NP0056

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval fat body, with Scer\GAL4^Lsp2.PH

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4^c649

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4^tsh-c724

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule Type I cell, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4^c42

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4^c649

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4^tsh-c724

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval midgut, with Scer\GAL4^da.G32

EcR^{B1-ΔC655.W650A.UAS}

embryonic/larval midgut | embryonic stage

embryonic/larval midgut | heat sensitive

EcR^GAL4::LBD.hs

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^RapGAP1-OK6

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval posterior spiracle, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

embryonic/larval posterior spiracle (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

embryonic/larval posterior spiracle (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

embryonic/larval salivary gland | cell autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

EcR^{dsRNA.UAS.cCa}

embryonic/larval salivary gland | embryonic stage, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

embryonic/larval salivary gland | embryonic stage (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

embryonic/larval salivary gland | embryonic stage (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

embryonic/larval salivary gland | heat sensitive

EcR^GAL4::LBD.hs

embryonic/larval salivary gland | prepupal stage, with Scer\GAL4^Sgs3.PD

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval salivary gland | pupal stage, with Scer\GAL4^Sgs3.PD

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4^fkh.PH

EcR^{dsRNA.UAS.cCa}

embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4^Sgs3.PD

EcR^{B1-ΔC655.F645A.UAS}

embryonic/larval tracheal system

EcR^M554fs

embryonic/larval tracheal system | heat sensitive, with Scer\GAL4^btl.PS

EcR^{B1-ΔC655.W650A.UAS}

embryonic head

EcR³¹⁸

embryonic midgut constriction

EcR^M554fs

epipharyngeal sclerite

EcR³¹⁸

eye

EcR^{A-ΔC655.F645A.UAS}

eye, with Scer\GAL4^ey-OK107

EcR^miRNA.UAS

eye, with Scer\GAL4^GMR.PF

EcR^{B1-ΔC655.F645A.UAS}

eye, with Scer\GAL4^GMR.PU

EcR^{dsRNA.UAS.cCa}

eye | somatic clone

EcR^M554fs

fat body, with Scer\GAL4^Lsp2.PH

EcR^{B1-ΔC655.W650A.UAS}

fat cell | pupal stage, with Scer\GAL4^Cg.PA

EcR^{dsRNA.UAS.cCa}

female germline cell | increased number, with Scer\GAL4^bab1-Pgal4-2

female germline cell | increased number | heat sensitive

female germline cell | somatic clone | increased number, with Scer\GAL4^Act.PU

EcR^{dsRNA.UAS.cCa}

follicle cell | heat sensitive

fusome | heat sensitive

gamma Kenyon cell, with Scer\GAL4^alrm.PD

gamma Kenyon cell, with Scer\GAL4^Tab2-201Y

EcR^{dsRNA.UAS.cCa}

gamma Kenyon cell | adult stage, with Scer\GAL4^GMR71G10

gamma Kenyon cell | adult stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^UAS.P2

EcR^gRNA.pCFD3-3

gamma Kenyon cell | somatic clone, with Scer\GAL4^alrm.PD

gamma-lobe & neuron (with EcR³¹)

EcR^W53st

gamma-lobe & neuron (with EcR^W53st)

EcR³¹

gastric caecum, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

gastric caecum (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

gastric caecum (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

gastric caecum | heat sensitive

EcR^GAL4::LBD.hs

germarium cap cell | increased number, with Scer\GAL4^bab1-Pgal4-2

germ band, with EcR^{B1-ΔC655.F645A.UAS}, Scer\GAL4^69B

EcR^M554fs

germ band, with EcR^{B1-ΔC655.F645A.UAS}, Scer\GAL4^c381

EcR^M554fs

germ band, with EcR^GAL4::LBD.hs

EcR^M554fs

germ band, with EcR^M554fs

EcR^GAL4::LBD.hs

germ band, with EcR^M554fs, Scer\GAL4^69B

EcR^{B1-ΔC655.F645A.UAS}

germ band, with EcR^M554fs, Scer\GAL4^c381

EcR^{B1-ΔC655.F645A.UAS}

germline cell | increased number | heat sensitive, with Scer\GAL4^bab1-Pgal4-2, Scer\GAL80^ts.αTub84B

EcR^{dsRNA.UAS.cCa}

germline cell | increased number | heat sensitive, with Scer\GAL4^ptc-559.1, Scer\GAL80^ts.αTub84B

EcR^{dsRNA.UAS.cCa}

glial cell & brain & pupa | conditional ts, with Scer\GAL4^Tab2-201Y

EcR^{B1-ΔC655.F645A.UAS}

head | pharate adult stage (with EcR¹¹²)

EcR^M554fs

head | pharate adult stage (with EcR^M554fs)

EcR¹¹²

head | pupal stage, with Scer\GAL4^Cg.PA

EcR^{dsRNA.UAS.cCa}

histoblast nest

EcR^W53st

ileum | adult stage, with Scer\GAL4^byn-Gal4

EcR^{B1-ΔC655.F645A.UAS}

imaginal disc, with Scer\GAL4^MsrA.657

EcR^{B1-ΔC655.F645A.UAS}

imaginal disc | heat sensitive

EcR^GAL4::LBD.hs

labral segment

EcR³¹⁸

larva

larval CCAP abdominal neuron | pupal stage (with EcR¹¹²)

EcR^M554fs

larval CCAP abdominal neuron | pupal stage (with EcR¹³⁹)

EcR^M554fs

larval CCAP abdominal neuron | pupal stage (with EcR^M554fs)

larval CCAP neuron | early third instar larval stage, with Scer\GAL4^CCAP.PP

EcR^{B1-ΔC655.W650A.UAS}

larval CCAP neuron | second instar larval stage, with Scer\GAL4^CCAP.PP

EcR^{B1-ΔC655.W650A.UAS}

larval CCAP neuron | third instar larval stage, with Scer\GAL4^Burs.PL

EcR^{B1-ΔC655.W650A.UAS}

larval CCAP neuron | third instar larval stage (with EcR³¹)

EcR⁹⁹

larval CCAP neuron | third instar larval stage (with EcR⁹⁹)

EcR³¹

larval CCAP neuron | wandering third instar larval stage, with Scer\GAL4^CCAP.PP

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^109(2)80

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

larval dorsal multidendritic neuron ddaC | P-stage, with Scer\GAL4^ppk.PU

EcR^{B1-ΔC655.W650A.UAS}

larval thoracic neuromere | somatic clone, with Scer\GAL4^elav-C155

EcR^{B1-ΔC655.W650A.UAS}

larval transverse nerve, with Scer\GAL4^RapGAP1-OK6

EcR^{B1-ΔC655.F645A.UAS}

leg

EcR^dsRNA.hs.PL

leg | adult stage | somatic clone, with Scer\GAL4^elav-C155

leg | pharate adult stage

EcR^k06210

leg | pharate adult stage (with EcR¹¹²)

EcR^M554fs

leg | pharate adult stage (with EcR¹³⁹)

EcR^M554fs

leg | pharate adult stage (with EcR^M554fs)

leg | pupal stage, with Scer\GAL4^CCAP.PP

lobe system of adult mushroom body

lobe system of adult mushroom body, with Scer\GAL4^c739

EcR^{dsRNA.UAS.cCa}

lobe system of adult mushroom body, with Scer\GAL4^let7C

EcR^{dsRNA.UAS.cCa}

local interneuron of larval antennal lobe | pupal stage, with Scer\GAL4^lilli-189Y

EcR^{B1-ΔC655.F645A.UAS}

local interneuron of larval antennal lobe | pupal stage, with Scer\GAL4^NP3056

EcR^{B1-ΔC655.F645A.UAS}

local interneuron of larval antennal lobe | pupal stage, with Scer\GAL4^orb-0449-G4

EcR^{B1-ΔC655.F645A.UAS}

lysosome, with Scer\GAL4^Lsp2.PH

EcR^{B1-ΔC655.W650A.UAS}

mesothoracic ventral neurosecretory neuron & axon, with Scer\GAL4^FMRFa.PS

metathoracic ventral thoracic neurosecretory neuron & axon, with Scer\GAL4^FMRFa.PS

microtubule & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^ppk.PG

EcR^{B1-ΔC655.W650A.UAS}

midgut, with Scer\GAL4^twi.PG

EcR^{B1-ΔC655.W650A.UAS}

midgut imaginal island

EcR^W53st

midgut imaginal island, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

midgut imaginal island (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

midgut imaginal island (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

mitotic domain 1 | extended germ band stage

mitotic domain 1 | extended germ band stage, with Scer\GAL4^69B

EcR^{B1-ΔC655.F645A.UAS}

mitotic domain 1 | extended germ band stage, with Scer\GAL4^c381

EcR^{B1-ΔC655.F645A.UAS}

mitotic domain 1 | extended germ band stage, with Scer\GAL4^hs.PB

EcR^{B1-ΔC655.F645A.UAS}

motor neuron | adult stage | somatic clone, with Scer\GAL4^elav-C155

mouth hook (with EcR¹¹²)

EcR^M554fs

mouth hook (with EcR^M554fs)

EcR¹¹²

mushroom body | P-stage, with Scer\GAL4^Tab2-201Y

EcR^{B1-ΔC655.F645A.UAS}

neuroblast | larval stage | somatic clone, with Scer\GAL4^elav-C155

EcR^{B1-ΔC655.W650A.UAS}

neuroblast | pupal stage, with Scer\GAL4^wor.PA, Scer\GAL80^ase.PN

neuroblast | pupal stage | somatic clone, with Scer\GAL4^elav-C155

EcR^{B1-ΔC655.W650A.UAS}

neurohemal organ, with Scer\GAL4^FMRFa.PS

neuron & ventral nerve cord, with Scer\GAL4^Crz.PC

neuron & ventral nerve cord (with EcR³¹)

EcR⁹⁹

neuron & ventral nerve cord (with EcR⁹⁹)

EcR³¹

nurse cell & nucleus | conditional ts

EcR^A483T

nurse cell ring canal | heat sensitive

ommatidium, with Scer\GAL4^GMR.PF

oocyte | oogenesis stage S10B | somatic clone, with Scer\GAL4^e22c

EcR^{B1-ΔC655.W650A.UAS}

oocyte | oogenesis stage S14 | heat sensitive

peptidergic neuron | pupal stage, with Scer\GAL4^Crz.PU

EcR^{B1-ΔC655.W650A.UAS}

peripodial epithelium

EcR^unspecified

photoreceptor, with Scer\GAL4^GMR.PF

EcR^{dsRNA.UAS.cCa}

pigment cell, with Scer\GAL4^GMR.PF

polar follicle cell, with Scer\GAL4^slbo.2.6

polytene chromosome puff, with Scer\GAL4^Sgs3.PD

EcR^{B1-ΔC655.F645A.UAS}

posterior scutellar bristle, with Scer\GAL4^dpp.blk1

EcR^{B1-ΔC655.F645A.UAS}

prepupal cuticle, with Scer\GAL4^en-e16E

EcR^A.UAS

primary spermatocyte cyst

EcR⁰⁶⁴¹⁰

prothoracic gland | third instar larval stage, with Scer\GAL4^phm.PO

prothoracic ventral neurosecretory neuron & axon, with Scer\GAL4^FMRFa.PS

pupa

EcR^dsRNA.hs.PL

pupa, with Scer\GAL4^MsrA.657

EcR^{B1-ΔC655.F645A.UAS}

pupal cuticle (with EcR¹³⁹)

EcR^M554fs

pupal cuticle (with EcR^M554fs)

EcR¹³⁹

pupal epidermis, with Scer\GAL4^NP0056

EcR^{B1-ΔC655.F645A.UAS}

puparial operculum (with EcR¹¹²)

EcR^M554fs

puparial operculum (with EcR^M554fs)

EcR¹¹²

puparium cuticle, with Scer\GAL4^da.G32

EcR^dsRNA.B1.UAS

puparium cuticle (with EcR⁹⁴)

EcR^M554fs

puparium cuticle (with EcR¹¹²)

EcR^M554fs

puparium cuticle (with EcR¹³⁹)

EcR^M554fs

puparium cuticle (with EcR^M554fs)

salivary gland

EcR^dsRNA.hs.PL

salivary gland (with EcR¹¹²)

EcR^M554fs

salivary gland (with EcR^M554fs)

EcR¹¹²

spermatid

EcR⁰⁶⁴¹⁰

spermatid & nucleus

EcR⁰⁶⁴¹⁰

spermatozoon

EcR⁰⁶⁴¹⁰

synapse, with Scer\GAL4^alrm.PD

synapse, with Scer\GAL4^Mhc.PW

tergite

Tv neuron & axon, with Scer\GAL4^FMRFa.PS

Tv neuron & filopodium, with Scer\GAL4^FMRFa.PS

EcR^{dsRNA.B1.UAS.cSa}

ventral thoracic disc, with EcR^M554fs/EcR^V559fs

EcR^B2.hs

ventral thoracic disc (with EcR^M554fs), with EcR^B2.hs

EcR^V559fs

ventral thoracic disc (with EcR^V559fs), with EcR^B2.hs

EcR^M554fs

wing

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^Eh.0.8

EcR^{B1-ΔC655.F645A.UAS}

wing | pupal stage, with Scer\GAL4^CCAP.PP

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

EcR^{A-ΔC655.F645A.UAS}

wing hair | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

EcR^{B1-ΔC655.F645A.UAS}

wing margin | heat sensitive, with Scer\GAL4^wg-IS650, Scer\GAL80^ts.αTub84B

EcR^{B1-ΔC655.F645A.UAS}

wing vein

EcR^k06210

wing vein, with Scer\GAL4^Bx-MS1096

wing vein | ectopic

EcR^k06210

wing vein L3 | ectopic

EcR^k06210

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\NR1H3

10 of 15

Yes

Hsap\NR1H2

9 of 15

Yes

Hsap\NR1H4

3 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\RARB

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Nr1h2

9 of 15

Yes

Mmus\Nr1h3

9 of 15

Yes

Mmus\Nr1h5

5 of 15

Yes

Mmus\Nr1h4

3 of 15

Yes

Mmus\Nr1i2

2 of 15

Mmus\Vdr

2 of 15

Mmus\1810013A23Rik

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Rarb

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (18)

Rnor\Nr1h2

8 of 13

Yes

Rnor\Nr1h3

8 of 13

Yes

Rnor\Nr1h5

5 of 13

Yes

Rnor\Nr1h4

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Rarb

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (15)

Xtro\nr1h2

9 of 12

Yes

Xtro\nr1h5

6 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\rarb

1 of 12

Yes

Xtro\rora

1 of 12

Xtro\rorb.2

1 of 12

Xtro\rorc

1 of 12

Danio rerio (Zebrafish) (25)

Drer\nr1h3

8 of 15

Yes

Drer\nr1h4

4 of 15

Yes

Drer\nr1h5

4 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\rarab

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\thrab

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (191)

Cele\nhr-118

3 of 15

Yes

Cele\nhr-44

2 of 15

Yes

Cele\nhr-53

2 of 15

Yes

Cele\nhr-87

2 of 15

Yes

Cele\nhr-112

2 of 15

Yes

Cele\nhr-132

2 of 15

Yes

Cele\nhr-134

2 of 15

Yes

Cele\nhr-181

2 of 15

Yes

Cele\nhr-182

2 of 15

Yes

Cele\nhr-199

2 of 15

Yes

Cele\nhr-213

2 of 15

Yes

Cele\nhr-219

2 of 15

Yes

Cele\nhr-234

2 of 15

Yes

Cele\nhr-237

2 of 15

Yes

Cele\nhr-238

2 of 15

Yes

Cele\unc-55

2 of 15

Cele\daf-12

1 of 15

Cele\dpr-1

1 of 15

Yes

Cele\nhr-6

1 of 15

Cele\nhr-8

1 of 15

Cele\nhr-9

1 of 15

Yes

Cele\nhr-12

1 of 15

Yes

Cele\nhr-15

1 of 15

Yes

Cele\nhr-16

1 of 15

Yes

Cele\nhr-18

1 of 15

Yes

Cele\nhr-19

1 of 15

Yes

Cele\nhr-21

1 of 15

Yes

Cele\nhr-26

1 of 15

Yes

Cele\nhr-27

1 of 15

Cele\nhr-28

1 of 15

Yes

Cele\nhr-30

1 of 15

Yes

Cele\nhr-37

1 of 15

Yes

Cele\nhr-39

1 of 15

Yes

Cele\nhr-42

1 of 15

Yes

Cele\nhr-43

1 of 15

Yes

Cele\nhr-50

1 of 15

Yes

Cele\nhr-51

1 of 15

Yes

Cele\nhr-52

1 of 15

Yes

Cele\nhr-54

1 of 15

Yes

Cele\nhr-55

1 of 15

Yes

Cele\nhr-56

1 of 15

Yes

Cele\nhr-57

1 of 15

Yes

Cele\nhr-58

1 of 15

Yes

Cele\nhr-59

1 of 15

Yes

Cele\nhr-61

1 of 15

Yes

Cele\nhr-63

1 of 15

Yes

Cele\nhr-65

1 of 15

Yes

Cele\nhr-68

1 of 15

Cele\nhr-70

1 of 15

Yes

Cele\nhr-72

1 of 15

Yes

Cele\nhr-73

1 of 15

Yes

Cele\nhr-76

1 of 15

Cele\nhr-77

1 of 15

Yes

Cele\nhr-79

1 of 15

Yes

Cele\nhr-81

1 of 15

Yes

Cele\nhr-82

1 of 15

Yes

Cele\nhr-84

1 of 15

Yes

Cele\nhr-86

1 of 15

Yes

Cele\nhr-90

1 of 15

Yes

Cele\nhr-92

1 of 15

Yes

Cele\nhr-94

1 of 15

Yes

Cele\nhr-95

1 of 15

Yes

Cele\nhr-96

1 of 15

Yes

Cele\nhr-98

1 of 15

Yes

Cele\nhr-99

1 of 15

Yes

Cele\nhr-100

1 of 15

Cele\nhr-102

1 of 15

Yes

Cele\nhr-103

1 of 15

Yes

Cele\nhr-104

1 of 15

Yes

Cele\nhr-105

1 of 15

Yes

Cele\nhr-106

1 of 15

Yes

Cele\nhr-108

1 of 15

Yes

Cele\nhr-109

1 of 15

Yes

Cele\nhr-110

1 of 15

Yes

Cele\nhr-114

1 of 15

Cele\nhr-115

1 of 15

Yes

Cele\nhr-117

1 of 15

Yes

Cele\nhr-122

1 of 15

Yes

Cele\nhr-123

1 of 15

Yes

Cele\nhr-124

1 of 15

Yes

Cele\nhr-125

1 of 15

Yes

Cele\nhr-126

1 of 15

Yes

Cele\nhr-127

1 of 15

Yes

Cele\nhr-128

1 of 15

Yes

Cele\nhr-130

1 of 15

Yes

Cele\nhr-131

1 of 15

Yes

Cele\nhr-133

1 of 15

Yes

Cele\nhr-135

1 of 15

Yes

Cele\nhr-138

1 of 15

Yes

Cele\nhr-139

1 of 15

Yes

Cele\nhr-140

1 of 15

Yes

Cele\nhr-143

1 of 15

Yes

Cele\nhr-145

1 of 15

Yes

Cele\nhr-150

1 of 15

Yes

Cele\nhr-155

1 of 15

Yes

Cele\nhr-156

1 of 15

Yes

Cele\nhr-157

1 of 15

Yes

Cele\nhr-158

1 of 15

Yes

Cele\nhr-159

1 of 15

Yes

Cele\nhr-161

1 of 15

Yes

Cele\nhr-162

1 of 15

Yes

Cele\nhr-163

1 of 15

Yes

Cele\nhr-164

1 of 15

Yes

Cele\nhr-165

1 of 15

Yes

Cele\nhr-166

1 of 15

Yes

Cele\nhr-167

1 of 15

Yes

Cele\nhr-169

1 of 15

Yes

Cele\nhr-170

1 of 15

Yes

Cele\nhr-171

1 of 15

Yes

Cele\nhr-172

1 of 15

Yes

Cele\nhr-174

1 of 15

Yes

Cele\nhr-175

1 of 15

Yes

Cele\nhr-176

1 of 15

Yes

Cele\nhr-177

1 of 15

Yes

Cele\nhr-178

1 of 15

Yes

Cele\nhr-179

1 of 15

Yes

Cele\nhr-180

1 of 15

Yes

Cele\nhr-183

1 of 15

Yes

Cele\nhr-184

1 of 15

Yes

Cele\nhr-185

1 of 15

Yes

Cele\nhr-186

1 of 15

Yes

Cele\nhr-187

1 of 15

Yes

Cele\nhr-188

1 of 15

Yes

Cele\nhr-189

1 of 15

Yes

Cele\nhr-190

1 of 15

Yes

Cele\nhr-192

1 of 15

Yes

Cele\nhr-193

1 of 15

Yes

Cele\nhr-194

1 of 15

Yes

Cele\nhr-195

1 of 15

Yes

Cele\nhr-196

1 of 15

Yes

Cele\nhr-197

1 of 15

Yes

Cele\nhr-198

1 of 15

Yes

Cele\nhr-201

1 of 15

Yes

Cele\nhr-202

1 of 15

Yes

Cele\nhr-203

1 of 15

Yes

Cele\nhr-205

1 of 15

Yes

Cele\nhr-210

1 of 15

Yes

Cele\nhr-211

1 of 15

Yes

Cele\nhr-212

1 of 15

Yes

Cele\nhr-214

1 of 15

Yes

Cele\nhr-216

1 of 15

Yes

Cele\nhr-217

1 of 15

Yes

Cele\nhr-218

1 of 15

Yes

Cele\nhr-222

1 of 15

Yes

Cele\nhr-223

1 of 15

Yes

Cele\nhr-225

1 of 15

Yes