• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\EcR

General Information
Symbol	Dmel\EcR	Species	D. melanogaster
Name	Ecdysone receptor	Annotation symbol	CG1765
Feature type	protein_coding_gene	FlyBase ID	FBgn0000546
Gene Model Status	Current	Stock availability	77 publicly available
Also Known As	EcR-B1, DmEcR, EcRB1, EcR-A, NR1H1, DEcR, lie, ms(2)42A
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42A9-42A12	Sequence location	2R:1,977,924..2,056,681 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ecdysone receptor is referred to in FlyBase by the symbol Dmel\EcR (CG1765, FBgn0000546). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ecdysteroid hormone receptor activity; protein binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; protein heterodimerization activity; repressing transcription factor binding. There is experimental evidence for 40 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular process involved in reproduction; multicellular organismal reproductive process; organ development; cellular component organization or biogenesis; embryonic development via the syncytial blastoderm; central nervous system development; post-embryonic organ morphogenesis; determination of adult lifespan; neuron maturation; locomotory behavior; catabolic process; response to cocaine; ecdysis, chitin-based cuticle; prepupal development; memory. 140 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; cuticle; imaginal precursor; cephalopharyngeal skeleton; female germline cyst; portion of tissue; egg; extended germ band embryo; cytoplasmic part; spiracle; external compound sense organ; gland. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Ecdysteroid receptor; Nuclear hormone receptor, ligand-binding; Nuclear hormone receptor, ligand-binding, core; Steroid hormone receptor; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632796_s_at completely aligns to an exonic region of only a subset of 4 of the 6 FlyBase-annotated transcript isoforms of EcR. Gene sequence location is 2R:1977924..2056681.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Dutko-Gwóźdź et al., 2008, Molec. Cell. Endocrinol. 294(1-2): 45--51
FB2012_01	References Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700 Gradilla et al., 2011, Genetics 189(3): 871--883 Kirilly et al., 2011, Neuron 72(1): 86--100 Bond et al., 2011, Dev. Biol. 360(2): 286--296 Sequence features HFA04906 BKN31288 HFA04910 Controlled Vocabulary Terms RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42A9-42A12   Limits computationally determined from genome sequence between P{lacW}l(2)k09848k09848&P{EP}EP407 and P{lacW}geminink14019&P{PZ}Adf101349
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42A10-42A12   (determined by in situ hybridisation) 42A1--19 (determined by in situ hybridisation)   (Spradling et al., 1999) 42A1-42A19   42A1--2 42A10--12 42A10--16   (BDGP Project Members, 1994-1999) 42A-42A   (determined by in situ hybridisation)   (Koelle et al., 1991)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\EcR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) EcR-RA FBtr0086008  NM_165461   5197   849 EcR-RB FBtr0086011  NM_165465   4089   878 EcR-RC FBtr0086012  NM_165464   4981   669 EcR-RD FBtr0086009  NM_165462   3740   849 EcR-RE FBtr0086010  NM_165463   5233   849 EcR-RG FBtr0302439  NM_001169590   5874   878
Additional Transcript Data & Comments
Reported size (kB)	6.0 (northern blot) (Koelle et al., 1991) 6, 5, 4 (northern blot) (Talbot et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein EcR-PA   FBpp0085349   91.2   849   7.71     NP_724456   AAF57278 EcR-PB   FBpp0085352   93.9   878   6.88     NP_724460   AAF57280 EcR-PC   FBpp0085353   73.3   669   6.76     NP_724459   AAM68347 EcR-PD   FBpp0085350   91.2   849   7.71     NP_724457   AAG22334 EcR-PE   FBpp0085351   91.2   849   7.71     NP_724458   AAM68346 EcR-PG   FBpp0291631   93.9   878   6.88     NP_001163061   ACZ94341
Additional Polypeptide Data & Comments
Reported size (kDa)	878 (aa); 105 (kD observed) (Koelle et al., 1991) 878, 849, 669 (aa); 105, 80 (kD) (Talbot et al., 1993)
Comments	Three EcR isoforms exist that differ in their N-terminal sequences. They have 652 C-terminal amino acids in common that contain the DNA- and hormone-binding domains. All were shown to function as ecdysone receptors in S2 cells. Monoclonal antibodies have been produced that specifically recognize two of the three EcR isoforms (all but EcR-B2). Monoclonal antibodies have also been produced against the region common to all of the EcR proteins. (Talbot et al., 1993, Talbot et al., 1993) Three EcR isoforms exist that differ in their N-terminal sequences. They have 652 C-terminal amino acids in common that contain the DNA- and hormone-binding domains. All were shown to function as ecdysone receptors in S2 cells. Monoclonal antibodies have been produced that specifically recognize two of the three EcR isoforms (all but EcR-B2 protein). Monoclonal antibodies have also been produced against the region common to all of the EcR proteins. (Talbot et al., 1993) alternatively spliced exon (FlyBase, 1992-) Monoclonal antibody was generated against amino acids 67-878 of this protein. Polyclonal antibody was generated against amino acids 335-447 of this protein. EcR protein expressed in Drosophila Schneider 2 cells is able to bind the ecdysone analog iodoponasterone A, and binding activity is lost by treatment with EcR antibody. Embryonic extracts also show ecdysone analog binding which is removable by antibody treatment. EcR protein is able to specifically bind ecdysone response element (EcRE) DNA. (Koelle et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nuclear hormone receptor, ligand-binding, core (IPR000536) Zinc finger, nuclear hormone receptor-type (IPR001628) Steroid hormone receptor (IPR001723) Ecdysteroid receptor (IPR003069) Nuclear hormone receptor, ligand-binding (IPR008946) Zinc finger, NHR/GATA-type (IPR013088)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201657   AA202510   AA246305   AA263370   AA391360   AA391462   AA438743   AA538642   AA539503   AA540854   AA567664   AA735619   AA941320   AA941361   AA978434   AA979330   AE013599 AAF57278   AE013599 AAF57280   AE013599 AAG22334   AE013599 AAM68346   AE013599 AAM68347   AE013599 ACZ94341   AI063285   AI258616   AI457009   AI511659   AI513045   AI514995   AI520411   AI520584   AI544194   AQ025786   AQ026415   AQ073646   AX407008   AY058575 AAL13804   AY060438   AY075461 AAL68274   BE976426   BH011418   BH759480   BI163162   BI166834   BI167732   BI170398   BI215745   BI230982   BI237603   BI238123   BI241640   BI356066   BI373487   BI485877   BI577728   BI635498   BT012469   BT015234 AAT94463   BX067382   BZ286306   CA807374   CL525863   CO178802   CO184318   CO189218   CO190212   CO267419   CO274307   CO280751   CO281709   CO286785   CO295210   CO301393   CO303536   CO303938   CO305086   CO305874   CO306702   CO308056   CO313402   CO316113   CO317115   CO318554   CO319875   CO333058   CZ467670   CZ467758   CZ468804   CZ468960   CZ468983   CZ471893   CZ476085   CZ476400   CZ478924   CZ481520   CZ481521   CZ483792   CZ483793   CZ484679   CZ484779   CZ484780   CZ486449   CZ486853   CZ486854   CZ490259   EC062759   EC064183   EC064186   EC064325   EC064950   EC065396   EC065744   EC066872   EC068743   EC069530   EC072629   EC073758   EC080519   EC084092   EC085238   EC085371   EC195365   EC195394   EC196738   EC198140   EC199382   EC203697   EC208354   EC210512   EC219502   EC219734   EC226068   EC227509   EC228274   EC229960   EC231133   EC231946   EC237962   EC238696   EC247382   EC248267   EC248505   EC249093   EC249920   EC255511   GH941655   GH943565   GH944216   GH944831   GH945195   GH945961   GH946093   GH946603   GH946921   GH947433   GH947577   GH947955   GH948323   GH949264   GH949471   GH950441   GH950661   GH951040   GH951227   GH951498   GH951997   GH952770   GH953395   GH954143   GH954172   GH954299   GH954510   GH954862   GH955629   GH956279   GH956371   GH957173   GH957314   GH957599   GH957845   GH958130   GH958382   GH959456   GH959676   GH959688   GH959749   GH960901   GH961101   GH961919   GH962085   GH962316   GH962810   GH963403   GH963732   GH964017   GH964493   GH964550   GH965536   GH966099   GH966191   GH966738   GH966843   GH966919   GH966937   GH967149   GH967171   GH967173   GH967229   GH967331   GH967452   GH968197   GH968703   GH968966   GH969350   GH969632   GH969713   GH970635   GH970653   GH970821   GH970951   GH971827   GH972238   GH973800   GH974127   GH974485   GH975134   GH975546   GH975625   GH975664   GH976301   GH976628   GH977930   GH978066   GH979183   GH979226   GH981481   GH981655   GH982363   GH982366   GH983555   GH983973   GH984374   GH984948   GH984978   M74078 AAA28498   S63761 AAB27496   S63762
UniProtKB/Swiss-Prot	P34021
UniProtKB/TrEMBL	A4UZ51 E1JGY2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late     (Talbot et al., 1993) embryonic stage | mid     (Talbot et al., 1993) embryonic stage 1 -- 6     (Talbot et al., 1993) Comment:reference states 0-3 hr AEL second instar larval stage     (Talbot et al., 1993) wandering third instar larval stage   organism   (Talbot et al., 1993) pupal stage | early     (Talbot et al., 1993) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid     (Talbot et al., 1993) embryonic stage | late     (Talbot et al., 1993) embryonic stage 7 -- 17     (Koelle et al., 1991) Comment:reference states >=3 hr AEL larval stage -- adult stage     (Koelle et al., 1991) first instar larval stage     (Talbot et al., 1993) third instar larval stage     (Talbot et al., 1993) pupal stage | mid     (Talbot et al., 1993) pupal stage     (Talbot et al., 1993)
Additional Descriptive Data
	The temporal pattern of EcR RNA expression was carefully studied and related to times of ecdysone pulses. The strongest peak of EcR-B1 RNA expression occurs in late third instar larvae. Smaller peaks are observed during late embryonic, late first and second instar larval, and mid pupal stages. (Talbot et al., 1993) The 6 kb EcR transcript is detected in all stages except for 0-3 hr embryos. Expression is most abundant in embryos and in late third instar larvae and early pupae, with highest levels seen in wandering third instar larvae. (Koelle et al., 1991) The temporal pattern of EcR RNA expression was carefully studied and related to times of ecdysone pulses. Peaks of the 5kb EcR-A RNA occur in mid-embryogenesis and early and late in pupation. (Talbot et al., 1993)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Talbot et al., 1993) first instar larval stage     (Talbot et al., 1993) prepupal stage   midgut imaginal island   (Talbot et al., 1993) epidermis   (Talbot et al., 1993) embryonic/larval muscle system   (Talbot et al., 1993) embryonic/larval midgut   (Talbot et al., 1993) embryonic/larval trachea   (Talbot et al., 1993) haltere disc   (Talbot et al., 1993) imaginal disc   (Talbot et al., 1993) foregut imaginal ring   (Talbot et al., 1993) ventral thoracic disc   (Talbot et al., 1993) immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage -- adult stage   CSD interneuron   (Roy et al., 2007) prepupal stage   Malpighian tubule   (Talbot et al., 1993) embryonic/larval fat body   (Talbot et al., 1993) embryonic/larval salivary gland   (Talbot et al., 1993) eye-antennal disc   (Talbot et al., 1993) foregut imaginal ring   (Talbot et al., 1993) hindgut imaginal ring   (Talbot et al., 1993) histoblast nest   (Talbot et al., 1993) labial disc   (Talbot et al., 1993) prothoracic gland   (Talbot et al., 1993) salivary gland imaginal ring   (Talbot et al., 1993) pupal stage   mushroom body gamma-lobe   (Watts et al., 2003) projection neuron | subset   (Marin et al., 2005) pupal stage P5 -- pharate adult stage P15   neuron | subset   (Robinow et al., 1993) Comment:reference states >=12 hr APF ventral nervous system | restricted   (Robinow et al., 1993) Comment:reference states >=12 hr APF adult stage   neuron | subset   (Robinow et al., 1993) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Koelle et al., 1991, Talbot et al., 1993) first instar larval stage     (Koelle et al., 1991) wandering third instar larval stage   organism   (Koelle et al., 1991) prepupal stage     (Koelle et al., 1991) pupal stage     (Koelle et al., 1991, Talbot et al., 1993) adult stage     (Koelle et al., 1991) ovary   (Carney and Bender, 2000) adult stage & oogenesis   nurse cell   (Carney and Bender, 2000) follicle cell   (Carney and Bender, 2000)
Additional Descriptive Data
	EcR protein is located in the nucleus in embryonic, late third instar larval and pupal tissues. EcR protein localizes to the nuclei of the cell lines in which it is overexpressed, even in the absence of ecdysone. (Marin et al., 2005, Koelle et al., 1991) A 105 kD EcR protein is detected in embryos, in late third instar larvae and in early pupae. Low levels of protein are also detected in first instar larvae and adults, but no protein is detected in second and early third instar larvae. EcR protein is distributed throughout embryonic, late third instar larval, and prepupal tissues and localizes to the nucleus. (Koelle et al., 1991) At the onset of metamorphosis, the EcR-A and EcR-B1 protein isoforms are expressed in most tissues and are found in approximately complimentary patterns. EcR-A protein is expressed predominantly in large imaginal discs and rings that achieve their size by cell division during metamorphosis. EcR-B1 protein is found mainly in tissues that are strictly larval and in small cell clusters that respond to ecdysone by extensive cell multiplication, such as histoblast nests and midgut imaginal islands. A temporal study of EcR-B1 protein expression through development shows that it is present from mid to late embryogenesis, is at low levels in larval stages and is higher again during pupal stages. (Talbot et al., 1993) Most neurons (type I neurons) express the "EcR-A" isoform at low levels throughout adult development. Approximately 300 neurons (type II neurons) in the pupal ventral CNS express "EcR-A", at about 10-fold higher levels than found in type I neurons. Expression is detected in about 29 cells at 12 hr APF, increases to about 300 neurons by 42 hr APF, and continues to be detected through the rest of pupal stages. The majority of the neurons are located in the abdominal and third thoracic neuromeres, with about 24 in in neuromeres T1 and T2. The neurons which express "EcR-A" at high levels undergo rapid degeneration in newly eclosed adults. The death of the type II neurons can be delayed by 20-hydroxyecdysone treatment. (Robinow et al., 1993) EcR-A and EcR-B1 protein staining is observed in follicle cells and nurse cells throughout egg chamber development. (Carney and Bender, 2000) At the onset of metamorphosis, the EcR-A and EcR-B1 protein isoforms are expressed in most tissues and are found in approximately complimentary patterns. EcR-A protein is expressed predominantly in large imaginal discs and rings that achieve their size by cell division during metamorphosis. EcR-B1 protein is found mainly in tissues that are strictly larval and in small cell clusters that respond to ecdysone by extensive cell multiplication, such as histoblast nests and midgut imaginal islands. A temporal study of EcR-A protein expression through development shows that it is present throughout embryonic and pupal stages and is present at low levels in first instar larvae. (Talbot et al., 1993) EcR-A and EcR-B1 protein staining is observed in follicle cells and nurse cells throughout egg chamber development. (Carney and Bender, 2000)
Marker for
Subcellular Localization
CV Term	nucleus (Talbot et al., 1993) nucleus (Carney and Bender, 2000) nucleus (Carney and Bender, 2000)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000546    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000546 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000546 expression level Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr    1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr    1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6    2215 larva L3 puffstage 7-9    1540 white prepupae new    481 white prepupae 12hr    1436 white prepupae 24hr    1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1103) embryo 02-04hr  (1101) embryo 04-06hr  (747) embryo 06-08hr  (1152) embryo 08-10hr  (1401) embryo 10-12hr  (1132) embryo 12-14hr  (1150) embryo 14-16hr  (1485) embryo 16-18hr  (1232) embryo 18-20hr  (1017) embryo 20-22hr  (664) embryo 22-24hr  (690) larva L1  (273) larva L2  (326) larva L3 12hr old  (345) larva L3 puffstage 1-2  (594) larva L3 puffstage 3-6  (2215) larva L3 puffstage 7-9  (1540) white prepupae new  (481) white prepupae 12hr  (1436) white prepupae 24hr  (1916) pupae 2d postWPP  (1293) pupae 3d postWPP  (618) pupae 4d postWPP  (313) adult male 01day  (252) adult male 05day  (244) adult male 30day  (227) adult female 01day  (541) adult female 05day  (705) adult female 30day  (737) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr  1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr  1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6  (2215) larva L3 puffstage 7-9  (1540) white prepupae new    481 white prepupae 12hr  1436 white prepupae 24hr  (1916) pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr    1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr    1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6    2215 larva L3 puffstage 7-9    1540 white prepupae new    481 white prepupae 12hr    1436 white prepupae 24hr    1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr    1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr    1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6    2215 larva L3 puffstage 7-9    1540 white prepupae new    481 white prepupae 12hr    1436 white prepupae 24hr    1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000546 expression level Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr    1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr    1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6    2215 larva L3 puffstage 7-9    1540 white prepupae new    481 white prepupae 12hr    1436 white prepupae 24hr    1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1103) embryo 02-04hr  (1101) embryo 04-06hr  (747) embryo 06-08hr  (1152) embryo 08-10hr  (1401) embryo 10-12hr  (1132) embryo 12-14hr  (1150) embryo 14-16hr  (1485) embryo 16-18hr  (1232) embryo 18-20hr  (1017) embryo 20-22hr  (664) embryo 22-24hr  (690) larva L1  (273) larva L2  (326) larva L3 12hr old  (345) larva L3 puffstage 1-2  (594) larva L3 puffstage 3-6  (2215) larva L3 puffstage 7-9  (1540) white prepupae new  (481) white prepupae 12hr  (1436) white prepupae 24hr  (1916) pupae 2d postWPP  (1293) pupae 3d postWPP  (618) pupae 4d postWPP  (313) adult male 01day  (252) adult male 05day  (244) adult male 30day  (227) adult female 01day  (541) adult female 05day  (705) adult female 30day  (737) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr  1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr  1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6  2215 larva L3 puffstage 7-9  1540 white prepupae new    481 white prepupae 12hr  1436 white prepupae 24hr  1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr    1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr    1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6    2215 larva L3 puffstage 7-9    1540 white prepupae new    481 white prepupae 12hr    1436 white prepupae 24hr    1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1103 embryo 02-04hr    1101 embryo 04-06hr    747 embryo 06-08hr    1152 embryo 08-10hr    1401 embryo 10-12hr    1132 embryo 12-14hr    1150 embryo 14-16hr    1485 embryo 16-18hr    1232 embryo 18-20hr    1017 embryo 20-22hr    664 embryo 22-24hr    690 larva L1    273 larva L2    326 larva L3 12hr old    345 larva L3 puffstage 1-2    594 larva L3 puffstage 3-6    2215 larva L3 puffstage 7-9    1540 white prepupae new    481 white prepupae 12hr    1436 white prepupae 24hr    1916 pupae 2d postWPP    1293 pupae 3d postWPP    618 pupae 4d postWPP    313 adult male 01day    252 adult male 05day    244 adult male 30day    227 adult female 01day    541 adult female 05day    705 adult female 30day    737 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000546    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000546 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval salivary gland, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000546 expression level Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000546 expression level Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    163.35 Larval Midgut    236.6 Larval Hindgut    325.4 Larval Malpighian Tubules    162.7 Larval Fat Body    188.4 Larval Salivary Gland    460.7 Larval Trachea    143.4 Larval Carcass    313.275 Adult Head    29.9 Adult Eye    26.95 Adult Brain    57.9 Adult Thoracic-Abdominal Ganglion    35.8 Adult Crop    44.8 Adult Midgut    19.8 Adult Hindgut    33.9 Adult Malpighian Tubules    25.9 Adult Fat Body    103.8 Adult Salivary Gland    44.8 Adult Heart    23.625 Adult VirginFemale Spermatheca    67.4 Adult InseminatedFemale Spermatheca    74.1 Adult Ovary    49.5 Adult Testis    6.2 Adult Male Accessory Gland    27.4 Adult Carcass    32.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    29.9   NA  Eye    26.95   NA  Brain    57.9   163.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    35.8   NA  Crop    44.8   236.6  Midgut    19.8   325.4  Hindgut    33.9   162.7  Malpighian Tubules    25.9   188.4  Fat Body    103.8   460.7  Salivary Gland    44.8   NA  Heart    23.625   143.4  Trachea    NA   NA  VirginFemale Spermatheca    67.4   NA  InseminatedFemale Spermatheca    74.1   NA  Ovary    49.5   NA  Testis    6.2   NA  Male Accessory Gland    27.4   313.275  Carcass    32.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000546 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1765-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal EcRA483T EcRC300Y EcRF288Y EcRk06210 EcRM554fs EcRNP2237 EcRNP5219 EcRV559fs lethal, with Scer\GAL4Act5C.PI EcRA.Scer\UAS EcRB1.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS EcRB2.Scer\UAS lethal, with Scer\GAL4GMR.PF EcRB1-ΔC655.F645A.Scer\UAS lethal, with Scer\GAL4Lsp2.PH EcRB1-ΔC655.F645A.Scer\UAS lethal, with Scer\GAL4pnr-MD237 EcRGD1428 lethal, with Scer\GAL4Ser.PGF EcRB1-ΔC655.F645A.Scer\UAS lethal (with EcR31) EcR99 lethal (with EcR99) EcR31 lethal | embryonic stage EcRB1-ΔC655.F645A.Scer\UAS EcRM554fs lethal | embryonic stage, with Scer\GAL469B EcRB1-ΔC655.F645A.Scer\UAS lethal | embryonic stage, with Scer\GAL4arm.PS EcRB1-ΔC655.F645A.Scer\UAS lethal | embryonic stage, with Scer\GAL4c381 EcRB1-ΔC655.F645A.Scer\UAS lethal | embryonic stage (with EcR52) EcRM554fs lethal | embryonic stage (with EcR120) EcRM554fs EcRW53st lethal | embryonic stage (with EcRM554fs) EcR52 EcR120 EcRV559fs lethal | embryonic stage (with EcRV559fs) EcRM554fs lethal | embryonic stage (with EcRW53st) EcR120 lethal | embryonic stage | heat sensitive EcRhs.T:Scer\GAL4 lethal | embryonic stage | heat sensitive, with EcRhs.T:Scer\GAL4 EcRM554fs lethal | embryonic stage | heat sensitive, with EcRM554fs EcRhs.T:Scer\GAL4 lethal | embryonic stage | heat sensitive, with Scer\GAL4hs.PB EcRB1-ΔC655.F645A.Scer\UAS lethal | embryonic stage | recessive EcR3L2 EcR5MM1 EcR6HH2 EcR6K1 EcR10-2 EcRC284Y EcRC306S EcRD491N EcRE261st EcRM308I EcRM554fs EcRP398sd EcRR344Q EcRV559fs EcRΔS447-K497 lethal | first instar larval stage, with Scer\GAL4C57 EcRB1-ΔC655.F645A.Scer\UAS lethal | first instar larval stage, with Scer\GAL4tsh-c724 EcRB1-ΔC655.F645A.Scer\UAS lethal | heat sensitive EcRA483T EcRB1.hs EcRB2.hs lethal | heat sensitive, with Scer\GAL4dpp.blk1 EcRB1-ΔC655.F645A.Scer\UAS lethal | heat sensitive (with EcRA483T) EcRNP5219 lethal | heat sensitive (with EcRNP5219) EcRA483T lethal | larval stage EcRB1-ΔC655.F645A.Scer\UAS EcRdsRNA.hs.PL lethal | larval stage, with Scer\GAL469B EcRB1-ΔC655.F645A.Scer\UAS lethal | larval stage, with Scer\GAL4c381 EcRB1-ΔC655.F645A.Scer\UAS lethal | larval stage, with Scer\GAL4c649 EcRB1-ΔC655.F645A.Scer\UAS lethal | larval stage, with Scer\GAL4OK6 EcRB1-ΔC655.F645A.Scer\UAS lethal | larval stage | heat sensitive EcRhs.T:Scer\GAL4 lethal | larval stage | recessive EcR2 EcR31 EcR80 EcR99 EcR214 EcR225 lethal | partially, with Scer\GAL4en-e16E EcRA.Scer\UAS EcRB1.Scer\UAS EcRB2.Scer\UAS lethal | partially | heat sensitive EcRA.hs lethal | pharate adult stage, with Scer\GAL4da.G32 EcRdsRNA.A.Scer\UAS lethal | pharate adult stage, with Scer\GAL4repo EcRA-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS lethal | pharate adult stage (with EcR112) EcRM554fs lethal | pharate adult stage (with EcRM554fs) EcR112 lethal | prepupal stage | heat sensitive EcRdsRNA.hs.PL lethal | pupal stage, with Scer\GAL4GMR.PF EcRB1-ΔC655.F645A.Scer\UAS lethal | pupal stage, with Scer\GAL4Mhc.PW EcRB1-ΔC655.F645A.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 EcRGD1428 lethal | pupal stage, with Scer\GAL4Tab2-201Y EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS lethal | pupal stage (with EcR112) EcRM554fs lethal | pupal stage (with EcR139) EcRM554fs lethal | pupal stage (with EcRM554fs) EcR112 EcR139 lethal | recessive EcR1ig21 EcR3C1 EcR4DD1 EcR4FF1 EcR4X4 EcR5K1 EcR6B2 EcR6II3 EcR318 EcRA483T EcRA612V EcRE261st EcRF288Y EcRk04314 EcRk04504 EcRk06210 EcRNP5219 EcRQ50st EcRR320H EcRS531T EcRV559fs EcRW53st lethal | recessive | heat sensitive EcRA483T EcRM554fs EcRR344Q EcRV559fs lethal | second instar larval stage (with EcR172) EcRM554fs lethal | second instar larval stage (with EcRM554fs) EcR172 lethal | third instar larval stage (with EcR94) EcRM554fs lethal | third instar larval stage (with EcRM554fs) EcR94 semi-lethal | first instar larval stage (with EcR172) EcRM554fs semi-lethal | first instar larval stage (with EcRM554fs) EcR172 semi-lethal | larval stage (with EcR31) EcR99 semi-lethal | larval stage (with EcR99) EcR31 semi-lethal | pharate adult stage (with EcR139) EcRM554fs semi-lethal | pharate adult stage (with EcRM554fs) EcR139 semi-lethal | pharate adult stage | recessive EcRk06210 semi-lethal | prepupal stage (with EcR112) EcRM554fs semi-lethal | prepupal stage (with EcRM554fs) EcR112 semi-lethal | pupal stage (with EcR11) EcRM554fs EcRW53st semi-lethal | pupal stage (with EcR112) EcRM554fs semi-lethal | pupal stage (with EcR139) EcRM554fs semi-lethal | pupal stage (with EcRM554fs) EcR11 EcR112 EcR139 semi-lethal | pupal stage (with EcRW53st) EcR11 semi-lethal | recessive EcR06410 semi-lethal | second instar larval stage (with EcR94) EcRM554fs semi-lethal | second instar larval stage (with EcR112) EcRM554fs semi-lethal | second instar larval stage (with EcR139) EcRM554fs semi-lethal | second instar larval stage (with EcRM554fs) EcR94 EcR112 EcR139 semi-lethal | third instar larval stage (with EcR112) EcRM554fs semi-lethal | third instar larval stage (with EcR139) EcRM554fs semi-lethal | third instar larval stage (with EcRM554fs) EcR112 EcR139 viable, with Scer\GAL4ey-OK107 EcRB1-ΔC655.W650A.Scer\UAS viable, with Scer\GAL4Sgs3.PD EcRB1-ΔC655.F645A.Scer\UAS Sterility Allele female sterile, with Scer\GAL4slbo.2.6 EcRB1-ΔC655.F645A.Scer\UAS female sterile | recessive | heat sensitive EcRA483T EcRM554fs EcRR344Q EcRV559fs male fertile, with Scer\GAL4nos.PG EcRA-ΔC655.W650A.Scer\UAS EcRdsRNA.A.Scer\UAS male sterile EcR06410 male sterile | recessive EcR06410 Other Phenotypes Allele cell death defective EcRdsRNA.hs.PL cell shape defective | somatic clone, with Scer\GAL4e22c EcRB1-ΔC655.W650A.Scer\UAS courtship behavior defective | conditional | dominant EcRA483T EcRC300Y EcRF288Y EcRNP2237 EcRNP5219 EcRV559fs courtship behavior defective | RU486 conditional, with Scer\GAL4elav.Switch.PO EcRdsRNA.Scer\UAS.cIa courtship behavior defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch EcRdsRNA.Scer\UAS.cIa decreased cell death, with Scer\GAL4Crz.PC EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS decreased cell death (with EcR31) EcR99 decreased cell death (with EcR99) EcR31 decreased cell size | somatic clone, with Scer\GAL4e22c EcRB1-ΔC655.W650A.Scer\UAS developmental rate defective, with Scer\GAL4c649 EcRB1-ΔC655.F645A.Scer\UAS feeding behavior defective | third instar larval stage (with EcR112) EcRM554fs feeding behavior defective | third instar larval stage (with EcR139) EcRM554fs feeding behavior defective | third instar larval stage (with EcRM554fs) EcR112 EcR139 locomotor behavior defective | third instar larval stage (with EcR112) EcRM554fs locomotor behavior defective | third instar larval stage (with EcR139) EcRM554fs locomotor behavior defective | third instar larval stage (with EcRM554fs) EcR112 EcR139 long lived EcRA483T EcRM554fs EcRV559fs long lived | dominant EcRV559fs long lived | male | RU486 conditional, with Scer\GAL4Switch1.106 EcRdsRNA.Scer\UAS.cCa memory defective | dominant EcRC300Y EcRF288Y EcRNP2237 EcRNP5219 EcRV559fs memory defective | dominant | heat sensitive EcRA483T memory defective | RU486 conditional, with Scer\GAL4elav.Switch.PO EcRdsRNA.Scer\UAS.cIa memory defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch EcRdsRNA.Scer\UAS.cIa mitotic cell cycle defective | somatic clone, with Scer\GAL4Act5C.PP EcRA-ΔC655.F645A.Scer\UAS neuroanatomy defective EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS neuroanatomy defective, with Scer\GAL4109(2)80 EcRB1-ΔC655.W650A.Scer\UAS EcRGD1428 neuroanatomy defective, with Scer\GAL4Fmrf.PS EcRA-ΔC655.F645A.Scer\UAS EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS EcRB2-ΔC655.W650A.Scer\UAS neuroanatomy defective, with Scer\GAL4Mhc.PW EcRA-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS neuroanatomy defective, with Scer\GAL4αTub84B.PP EcRB1-ΔC655.W650A.Scer\UAS neuroanatomy defective (with EcR31) EcR99 neuroanatomy defective (with EcR99) EcR31 neuroanatomy defective | pupal stage, with Scer\GAL4ppk.PG EcRB1-ΔC655.F645A.Scer\UAS short lived | female | RU486 conditional, with Scer\GAL4da.Switch.PT EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS EcRdsRNA.Scer\UAS.cCa sleep defective, with Scer\GAL4Mef2.247.Switch EcRA.Scer\UAS EcRB1.Scer\UAS sleep defective | dominant EcRA483T EcRF288Y EcRNP5219 EcRV559fs sleep defective | heat sensitive (with EcRA483T) EcRNP5219 sleep defective | heat sensitive (with EcRNP5219) EcRA483T small body | larval stage, with Scer\GAL4c649 EcRB1-ΔC655.F645A.Scer\UAS small body | larval stage, with Scer\GAL4tsh-c724 EcRB1-ΔC655.F645A.Scer\UAS visible | recessive | somatic clone EcRM554fs Phenotype manifest in Allele adult brain (with EcR31) EcRW53st adult brain (with EcRW53st) EcR31 adult midgut EcRdsRNA.hs.PL anterior crossvein | ectopic EcRk06210 anterior pupal spiracle (with EcR94) EcRM554fs anterior pupal spiracle (with EcRM554fs) EcR94 autophagic vacuole, with Scer\GAL4Lsp2.PH EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6 EcRB1-ΔC655.F645A.Scer\UAS EcRB1.Scer\UAS EcRB2.Scer\UAS EcRC.Scer\UAS cephalopharyngeal skeleton, with EcRM554fs/EcRV559fs EcRB2.hs cephalopharyngeal skeleton, with Scer\GAL469B EcRB1-ΔC655.W650A.Scer\UAS cephalopharyngeal skeleton (with EcRM554fs), with EcRB2.hs EcRV559fs cephalopharyngeal skeleton (with EcRV559fs), with EcRB2.hs EcRM554fs chorion, with Scer\GAL4slbo.2.6 EcRB1-ΔC655.F645A.Scer\UAS CSD interneuron, with Scer\GAL4αTub84B.PP EcRB1-ΔC655.W650A.Scer\UAS dendrite, with Scer\GAL4109(2)80 EcRB1-ΔC655.W650A.Scer\UAS EcRGD1428 dendritic arborizing neuron | P-stage, with Scer\GAL4ppk.PG EcRB1-ΔC655.F645A.Scer\UAS denticle belt, with Scer\GAL469B EcRB1-ΔC655.W650A.Scer\UAS dorsal appendage, with Scer\GAL4slbo.2.6 EcRB1-ΔC655.F645A.Scer\UAS dorsal appendage | maternal effect, with Scer\GAL4slbo.2.6 EcRB1-ΔC655.F645A.Scer\UAS dorsal closure embryo EcRhs.T:Scer\GAL4 dorsal closure embryo, with Scer\GAL4hs.PB EcRB1-ΔC655.F645A.Scer\UAS dorsal multidendritic neuron ddaC, with Scer\GAL4109(2)80 EcRB1-ΔC655.W650A.Scer\UAS EcRGD1428 dorsal pouch EcR318 egg chamber EcRA483T egg chamber | germline clone EcRM554fs egg chamber | heat sensitive EcRA483T EcRM554fs EcRR344Q EcRV559fs egg operculum, with Scer\GAL4slbo.2.6 EcRB1-ΔC655.F645A.Scer\UAS embryo | dorsal closure stage EcRM554fs embryo | dorsal closure stage, with Scer\GAL469B EcRB1-ΔC655.W650A.Scer\UAS embryo | embryonic stage 14 EcRM554fs embryo | embryonic stage 14, with Scer\GAL469B EcRB1-ΔC655.W650A.Scer\UAS embryonic/first instar larval cuticle EcRhs.T:Scer\GAL4 embryonic/first instar larval cuticle, with Scer\GAL4hs.PB EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval cuticle, with EcRM554fs/EcRV559fs EcRB2.hs embryonic/larval cuticle (with EcRM554fs), with EcRB2.hs EcRV559fs embryonic/larval cuticle (with EcRV559fs), with EcRB2.hs EcRM554fs embryonic/larval epidermis, with Scer\GAL4NP0056 EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval fat body, with Scer\GAL4Lsp2.PH EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4c649 EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4tsh-c724 EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4c649 EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval Malpighian tubule Type II cell, with Scer\GAL4tsh-c724 EcRB1-ΔC655.F645A.Scer\UAS embryonic/larval midgut | embryonic stage EcRW53st EcRdsRNA.hs.PL embryonic/larval midgut | heat sensitive EcRhs.T:Scer\GAL4 embryonic/larval posterior spiracle, with EcRM554fs/EcRV559fs EcRB2.hs embryonic/larval posterior spiracle (with EcRM554fs), with EcRB2.hs EcRV559fs embryonic/larval posterior spiracle (with EcRV559fs), with EcRB2.hs EcRM554fs embryonic/larval salivary gland | embryonic stage, with EcRM554fs/EcRV559fs EcRB2.hs embryonic/larval salivary gland | embryonic stage (with EcRM554fs), with EcRB2.hs EcRV559fs embryonic/larval salivary gland | embryonic stage (with EcRV559fs), with EcRB2.hs EcRM554fs embryonic/larval salivary gland | heat sensitive EcRhs.T:Scer\GAL4 embryonic/larval tracheal system EcRM554fs embryonic/larval tracheal system | heat sensitive, with Scer\GAL4btl.PS EcRB1-ΔC655.W650A.Scer\UAS embryonic head EcR318 epipharyngeal sclerite EcR318 extended germ band embryo EcRB1-ΔC655.F645A.Scer\UAS EcRhs.T:Scer\GAL4 extended germ band embryo, with Scer\GAL469B EcRB1-ΔC655.F645A.Scer\UAS extended germ band embryo, with Scer\GAL4c381 EcRB1-ΔC655.F645A.Scer\UAS extended germ band embryo, with Scer\GAL4hs.PB EcRB1-ΔC655.F645A.Scer\UAS eye EcRA-ΔC655.F645A.Scer\UAS eye, with Scer\GAL4GMR.PF EcRB1-ΔC655.F645A.Scer\UAS eye | somatic clone EcRM554fs female germline cell | somatic clone | supernumerary, with Scer\GAL4Act.PU EcRdsRNA.Scer\UAS.cCa female germline cell | supernumerary, with Scer\GAL4bab1-Pgal4-2 EcRA.Scer\UAS EcRB1.Scer\UAS female germline cell | supernumerary | heat sensitive EcRA.hs EcRB1.hs EcRhs.T:Scer\GAL4 follicle cell | heat sensitive EcRA483T EcRM554fs EcRR344Q EcRV559fs fusome | heat sensitive EcRA.hs EcRB1.hs gamma-lobe & neuron (with EcR31) EcRW53st gamma-lobe & neuron (with EcRW53st) EcR31 gastric caecum, with EcRM554fs/EcRV559fs EcRB2.hs gastric caecum (with EcRM554fs), with EcRB2.hs EcRV559fs gastric caecum (with EcRV559fs), with EcRB2.hs EcRM554fs gastric caecum | heat sensitive EcRhs.T:Scer\GAL4 germarium cap cell | supernumerary, with Scer\GAL4bab1-Pgal4-2 EcRA.Scer\UAS EcRB1.Scer\UAS germ band, with EcRB1-ΔC655.F645A.Scer\UAS, Scer\GAL469B EcRM554fs germ band, with EcRB1-ΔC655.F645A.Scer\UAS, Scer\GAL4c381 EcRM554fs germ band, with EcRhs.T:Scer\GAL4 EcRM554fs germ band, with EcRM554fs EcRhs.T:Scer\GAL4 germ band, with EcRM554fs, Scer\GAL469B EcRB1-ΔC655.F645A.Scer\UAS germ band, with EcRM554fs, Scer\GAL4c381 EcRB1-ΔC655.F645A.Scer\UAS germline cell | supernumerary | heat sensitive, with Scer\GAL4bab1-Pgal4-2, Scer\GAL80ts.αTub84B EcRdsRNA.Scer\UAS.cCa germline cell | supernumerary | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B EcRdsRNA.Scer\UAS.cCa glial cell & brain & pupa | conditional ts, with Scer\GAL4Tab2-201Y EcRB1-ΔC655.F645A.Scer\UAS head | pharate adult stage (with EcR112) EcRM554fs head | pharate adult stage (with EcRM554fs) EcR112 histoblast nest EcRW53st imaginal disc, with Scer\GAL4Eip71CD.657 EcRB1-ΔC655.F645A.Scer\UAS imaginal disc | heat sensitive EcRhs.T:Scer\GAL4 labral segment EcR318 larva EcR214 EcRunspecified larval neuromere | somatic clone, with Scer\GAL4elav-C155 EcRB1-ΔC655.W650A.Scer\UAS leg EcRdsRNA.hs.PL leg | adult stage | somatic clone, with Scer\GAL4elav-C155 EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS leg | pharate adult stage EcRk06210 leg | pharate adult stage (with EcR112) EcRM554fs leg | pharate adult stage (with EcR139) EcRM554fs leg | pharate adult stage (with EcRM554fs) EcR112 EcR139 lysosome, with Scer\GAL4Lsp2.PH EcRB1-ΔC655.W650A.Scer\UAS mesothoracic ventral neurosecretory neuron & axon, with Scer\GAL4Fmrf.PS EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS EcRB2-ΔC655.W650A.Scer\UAS metathoracic ventral thoracic neurosecretory neuron & axon, with Scer\GAL4Fmrf.PS EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS EcRB2-ΔC655.W650A.Scer\UAS microtubule & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG EcRB1-ΔC655.W650A.Scer\UAS midgut, with Scer\GAL4twi.PG EcRB1-ΔC655.W650A.Scer\UAS midgut constriction EcRM554fs midgut imaginal island EcRW53st midgut imaginal island, with EcRM554fs/EcRV559fs EcRB2.hs midgut imaginal island (with EcRM554fs), with EcRB2.hs EcRV559fs midgut imaginal island (with EcRV559fs), with EcRB2.hs EcRM554fs motor neuron | adult stage | somatic clone, with Scer\GAL4elav-C155 EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS mouth hooks (with EcR112) EcRM554fs mouth hooks (with EcRM554fs) EcR112 mushroom body (with EcR31) EcRW53st mushroom body (with EcRW53st) EcR31 mushroom body | P-stage, with Scer\GAL4Tab2-201Y EcRB1-ΔC655.F645A.Scer\UAS neuroblast | larval stage | somatic clone, with Scer\GAL4elav-C155 EcRB1-ΔC655.W650A.Scer\UAS neuroblast | pupal stage | somatic clone, with Scer\GAL4elav-C155 EcRB1-ΔC655.W650A.Scer\UAS neurohemal organ, with Scer\GAL4Fmrf.PS EcRA-ΔC655.F645A.Scer\UAS EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS EcRB2-ΔC655.W650A.Scer\UAS neuron & ventral nerve cord, with Scer\GAL4Crz.PC EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS neuron & ventral nerve cord (with EcR31) EcR99 neuron & ventral nerve cord (with EcR99) EcR31 nurse cell & nucleus | conditional ts EcRA483T nurse cell ring canal | heat sensitive EcRA483T EcRV559fs ommatidium, with Scer\GAL4GMR.PF EcRA-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS oocyte | oogenesis stage S10B | somatic clone, with Scer\GAL4e22c EcRB1-ΔC655.W650A.Scer\UAS peripodial epithelium EcRunspecified pigment cell, with Scer\GAL4GMR.PF EcRA-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS polar follicle cell, with Scer\GAL4slbo.2.6 EcRB1.Scer\UAS EcRB2.Scer\UAS EcRC.Scer\UAS polytene chromosome puff, with Scer\GAL4Sgs3.PD EcRB1-ΔC655.F645A.Scer\UAS posterior scutellar bristle, with Scer\GAL4dpp.blk1 EcRB1-ΔC655.F645A.Scer\UAS prepupal cuticle, with Scer\GAL4en-e16E EcRA.Scer\UAS primary spermatocyte cyst EcR06410 prothoracic ventral neurosecretory neuron & axon, with Scer\GAL4Fmrf.PS EcRA-ΔC655.W650A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.W650A.Scer\UAS EcRB2-ΔC655.W650A.Scer\UAS pupa EcRdsRNA.hs.PL pupa, with Scer\GAL4Eip71CD.657 EcRB1-ΔC655.F645A.Scer\UAS pupal cuticle (with EcR139) EcRM554fs pupal cuticle (with EcRM554fs) EcR139 pupal epidermis, with Scer\GAL4NP0056 EcRB1-ΔC655.F645A.Scer\UAS puparial operculum (with EcR112) EcRM554fs puparial operculum (with EcRM554fs) EcR112 puparium, with Scer\GAL4da.G32 EcRdsRNA.B1.Scer\UAS puparium (with EcR94) EcRM554fs puparium (with EcR112) EcRM554fs puparium (with EcR139) EcRM554fs puparium (with EcRM554fs) EcR112 EcR139 EcR94 salivary gland EcRdsRNA.hs.PL salivary gland (with EcR112) EcRM554fs salivary gland (with EcRM554fs) EcR112 spermatid EcR06410 spermatid & nucleus EcR06410 spermatozoon EcR06410 stage S14 oocyte | heat sensitive EcRA483T EcRM554fs EcRR344Q EcRV559fs synapse, with Scer\GAL4Mhc.PW EcRA-ΔC655.F645A.Scer\UAS EcRB1-ΔC655.F645A.Scer\UAS tergite EcRA483T EcRE261st Tv neuron & axon, with Scer\GAL4Fmrf.PS EcRA-ΔC655.F645A.Scer\UAS EcRdsRNA.B1.Scer\UAS.cSa Tv neuron & filopodium, with Scer\GAL4Fmrf.PS EcRdsRNA.B1.Scer\UAS.cSa ventral thoracic disc, with EcRM554fs/EcRV559fs EcRB2.hs ventral thoracic disc (with EcRM554fs), with EcRB2.hs EcRV559fs ventral thoracic disc (with EcRV559fs), with EcRB2.hs EcRM554fs wing EcRA483T EcRE261st EcRk06210 wing, with Scer\GAL4Eh.0.8 EcRB1-ΔC655.F645A.Scer\UAS wing disc | somatic clone, with Scer\GAL4Act5C.PP EcRA-ΔC655.F645A.Scer\UAS wing vein EcRk06210 wing vein | ectopic EcRk06210 wing vein L3 | ectopic EcRk06210
Classical Alleles ( 105 )
For All Classical Alleles Show
Allele of EcR Class Mutagen Stocks Known lesion EcR31 amorphic allele - genetic evidence Delta2-3 2 Yes EcRM554fs amorphic allele - genetic evidence, loss of function allele 2 Yes EcRQ50st amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes EcR06410 P-element activity 2 Yes EcR225 Delta2-3 2 Yes EcRA483T ethyl methanesulfonate 2 Yes EcRk06210 hypomorphic allele - genetic evidence P-element activity 2 Yes EcRV559fs loss of function allele ethyl methanesulfonate 2 Yes EcRW53st ethyl methanesulfonate 2 Yes EcR112 amorphic allele - genetic evidence Delta2-3 1 Yes EcR139 Delta2-3 1 Yes EcR5-HA-1968 1 -- EcR5-HA-2856 1 -- EcR5-SZ-3118 1 -- EcRc01365 1 -- EcRc02091 piggyBac transposase 1 -- EcRc02192 piggyBac transposase 1 -- EcRc03719 piggyBac transposase 1 -- EcRc04015 piggyBac transposase 1 -- EcRCB-0406-3 1 -- EcRCB-0500-3 1 -- EcRCB-5422-3 1 -- EcRd00918 P-element activity 1 -- EcRd03255 1 -- EcRd08765 P-element activity 1 -- EcRDG25401 P-element activity 1 -- EcRDG37811 P-element activity 1 -- EcRe01108 piggyBac transposase 1 -- EcRe03767 piggyBac transposase 1 -- EcREP2509 P-element activity 1 -- EcREY01667 P-element activity 1 -- EcREY16365 P-element activity 1 -- EcRf01319 piggyBac transposase 1 -- EcRf02276 piggyBac transposase 1 -- EcRf04318 piggyBac transposase 1 -- EcRf07518 piggyBac transposase 1 -- EcRk04314 P-element activity 1 -- EcRk04504 P-element activity 1 Yes EcRKG01921 1 -- EcRKG04522 P-element activity 1 -- EcRKG07941 1 -- EcRKG08480a P-element activity 1 -- EcRNP2237 1 -- EcRNP5190 1 -- EcRNP5219 1 -- EcRNP7086 1 -- EcR99 amorphic allele - genetic evidence Delta2-3 0 Yes EcR10-2 loss of function allele 0 Yes EcR11 Delta2-3 0 Yes EcR120 Delta2-3 0 Yes EcR1223 Delta2-3 0 Yes EcR127 Delta2-3 0 Yes EcR127A Delta2-3 0 Yes EcR172 Delta2-3 0 Yes EcR1ig21 0 -- EcR214 Delta2-3 0 Yes EcR298 Delta2-3 0 Yes EcR2 Delta2-3 0 Yes EcR318 0 -- EcR3C1 0 -- EcR3L2 ethyl methanesulfonate 0 Yes EcR4DD1 0 -- EcR4FF1 0 -- EcR4X4 0 -- EcR5-HA-2169 0 -- EcR52 Delta2-3 0 Yes EcR53 0 -- EcR554 0 -- EcR59 Delta2-3 0 Yes EcR59C Delta2-3 0 Yes EcR5K1 ethyl methanesulfonate 0 Yes EcR5MM1 0 -- EcR6B2 ethyl methanesulfonate 0 Yes EcR6HH2 0 -- EcR6II3 0 -- EcR6K1 0 -- EcR6PP2 ethyl methanesulfonate 0 Yes EcR80 Delta2-3 0 Yes EcR94 Delta2-3 0 Yes EcRA612V ethyl methanesulfonate 0 Yes EcRBG01729a P-element activity 0 -- EcRc04100 piggyBac transposase 0 -- EcRC284Y ethyl methanesulfonate 0 Yes EcRC300Y loss of function allele 0 Yes EcRC306S ethyl methanesulfonate 0 Yes EcRCB-0407-3 0 -- EcRd08127 P-element activity 0 -- EcRD491N ethyl methanesulfonate 0 Yes EcRE261st ethyl methanesulfonate 0 Yes EcREP407 0 -- EcRf02171 piggyBac transposase 0 -- EcRf03852 piggyBac transposase 0 -- EcRF288Y ethyl methanesulfonate 0 Yes EcRM308I ethyl methanesulfonate 0 Yes EcRM544fs 0 -- EcROD1223 Delta2-3 0 Yes EcROD298A Delta2-3 0 Yes EcRP398sd ethyl methanesulfonate 0 Yes EcRPM-1 ethyl methanesulfonate 0 Yes EcRPM-2 ethyl methanesulfonate 0 Yes EcRR320H ethyl methanesulfonate 0 Yes EcRR344Q ethyl methanesulfonate 0 Yes EcRS531T ethyl methanesulfonate 0 Yes EcRunspecified 0 -- EcRΔS447-K497 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Allele of EcR Class Mutagen Stocks Known lesion EcRhs.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes EcRGD1428 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes EcRA-ΔC655.F645A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes EcRA-ΔC655.W650A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes EcRA.hs in vitro construct - regulatory fusion 1 Yes EcRA.Scer\UAS in vitro construct - regulatory fusion 1 Yes EcRB1-ΔC655.F645A.Scer\UAS antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - amino acid replacement 1 Yes EcRB1-ΔC655.W650A.Scer\UAS antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - amino acid replacement 1 Yes EcRB1.hs in vitro construct - regulatory fusion 1 Yes EcRB1.Scer\UAS in vitro construct - regulatory fusion 1 Yes EcRB2-ΔC655.F645A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes EcRB2-ΔC655.W650A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes EcRB2.hs in vitro construct - regulatory fusion 1 Yes EcRB2.Scer\UAS in vitro construct - regulatory fusion 1 Yes EcRC.Scer\UAS in vitro construct - regulatory fusion 1 Yes EcRdsRNA.A.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EcRdsRNA.B1.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EcRdsRNA.hs.PL in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes EcRJF02538 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EcR15A.C in vitro construct 0 Yes EcR8A in vitro construct 0 Yes EcRAct5C.330-878.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes EcRAct5C.PK in vitro construct - regulatory fusion 0 Yes EcRB1.Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes EcRcDa in vitro construct 0 Yes EcRdsRNA.B1.Scer\UAS.cSa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes EcRdsRNA.B1 in vitro construct - RNAi 0 Yes EcRdsRNA.cBa in vitro construct - RNAi 0 Yes EcRdsRNA.cBb in vitro construct - RNAi 0 Yes EcRdsRNA.Scer\UAS.cCa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes EcRdsRNA.Scer\UAS.cIa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes EcRhs.B1.C.T:Ecol\dam,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes EcRhs.B1.N.T:Ecol\dam,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes EcRMtnA.PD in vitro construct - regulatory fusion 0 Yes EcRMtnA.PK in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)20B (Bender, 1996) Df(2R)BSC313 (Christensen et al., 2007.10.29) Df(2R)BSC889 (Cook and Cook, 2010.10.13) Df(2R)BSC890 (Cook and Cook, 2010.10.13) Df(2R)nap1 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Bender, 1996, Gellon et al., 1997) Df(2R)nap2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)nap5 (Bender, 1996) Df(2R)nap9 (Gellon et al., 1997) Df(2R)nap11 (Bender, 1996) Df(2R)nap17 (Bender, 1996) In(2LR)10-2 (Bender et al., 1997)
Not disrupted in	Df(2R)cn88b (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)M41A4 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{EcR.ET-AG-LacZ} No P{EcR.ET-GH-LacZ} No P{EcR.PLZ-AB-LacZ} No P{EcR.PLZ-AG-LacZ} No P{EcR.PLZ-BD-LacZ} No P{EcR.PLZ-DG-LacZ} No UAS construct P{GD1428} NA P{TRiP.JF02538} NA P{UAS-EcR.A.dsRNA} NA P{UAS-EcR.A.F645A} NA P{UAS-EcR.A.W650A} NA P{UAS-EcR.A} NA P{UAS-EcR.B1.dsRNA} NA P{UAS-EcR.B1} NA P{UAS-EcR.B1-ΔC655.F645A} NA P{UAS-EcR.B1-ΔC655.W650A} NA P{UAS-EcR.B2} NA P{UAS-EcR.C} NA P{UAS-EcR-RNAi} NA heat-shock construct P{hs-EcR.A} NA P{hs-EcR.B1} NA P{hs-EcR.B2} NA P{hs-EcRi} NA P{hs-GAL4-EcR.LBD} NA characterization construct P{EcRE.lacZ} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}EcR11 No P{lacW}EcR59 No P{lacW}EcR59C No P{lacW}EcR112 No P{lacW}EcR127 No P{lacW}EcR127A No P{lacW}EcR298 No P{lacW}EcR1223 No P{lacW}EcRk04314 No P{lacW}EcRk04504 No P{lacW}EcRk06210 No P{lacW}EcROD298A No P{lacW}EcROD1223 No P{lacW}l(2)SH0556SH0556 No P{PZ}EcR06410 No insertion of mobile activating element P{EP}EcREP407 NA P{EP}EcREP2509 NA P{EPgy2}EcREY01667 NA P{EPgy2}EcREY16365 NA P{XP}EcRd00918 NA P{XP}EcRd03255 NA P{XP}EcRd08127 NA P{XP}EcRd08765 NA miscellaneous insertions P{?lacW}EcR2 NA P{?lacW}EcR31 NA P{?lacW}EcR139 NA P{GT1}EcRBG01729a NA P{RS3}EcRCB-0406-3 NA P{RS3}EcRCB-0407-3 NA P{RS3}EcRCB-0500-3 NA P{RS3}EcRCB-5422-3 NA P{RS5}EcR5-HA-1968 NA P{RS5}EcR5-HA-2169 NA P{RS5}EcR5-HA-2856 NA P{RS5}EcR5-SZ-3118 NA P{SUPor-P}EcRKG01921 NA P{SUPor-P}EcRKG04522 NA P{SUPor-P}EcRKG07941 NA P{SUPor-P}EcRKG08480a NA P{wHy}EcRDG25401 NA P{wHy}EcRDG37811 NA PBac{PB}EcRc01365 NA PBac{PB}EcRc02091 NA PBac{PB}EcRc02192 NA PBac{PB}EcRc03719 NA PBac{PB}EcRc04015 NA PBac{PB}EcRc04100 NA PBac{RB}EcRe01108 NA PBac{RB}EcRe03767 NA PBac{WH}EcRf01319 NA PBac{WH}EcRf02171 NA PBac{WH}EcRf02276 NA PBac{WH}EcRf03852 NA PBac{WH}EcRf04318 NA PBac{WH}EcRf07518 NA insertion of enhancer trap binary system P{GawB}EcRNP2237 No P{GawB}EcRNP5190 No P{GawB}EcRNP5219 No P{GawB}EcRNP7086 No
Gene Ontology: Function, Process & Cellular Component ( 61 unique terms )
Terms Based on Experimental Evidence ( 50 terms )
Molecular Function
CV term Evidence References
ecdysteroid hormone receptor activity inferred from direct assay (Talbot et al., 1993, Koelle et al., 1991) contributes_to ecdysteroid hormone receptor activity inferred from physical interaction with usp (Zelhof et al., 1995) protein binding inferred from physical interaction with rig (Gates et al., 2004) protein heterodimerization activity inferred from direct assay (Bitra and Palli, 2009) inferred from physical interaction with usp (Zelhof et al., 1995) repressing transcription factor binding inferred from physical interaction with alien (Dressel et al., 1999) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Koelle et al., 1991) contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from physical interaction with usp (Zelhof et al., 1995)
Biological Process
CV term Evidence References
autophagy inferred from mutant phenotype (Rusten et al., 2004) axonogenesis inferred from mutant phenotype (Brown et al., 2006) border follicle cell migration inferred from mutant phenotype (Medioni and Noselli, 2005, Bai et al., 2000, Jang et al., 2009) cardiac muscle tissue development inferred from mutant phenotype (Monier et al., 2005) cardioblast differentiation inferred from mutant phenotype (Monier et al., 2005) cell adhesion inferred from mutant phenotype (D'Avino and Thummel, 2000) chitin-based embryonic cuticle biosynthetic process inferred from mutant phenotype (Kozlova and Thummel, 2003) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) determination of adult lifespan inferred from mutant phenotype (Simon et al., 2003) dorsal vessel heart proper cell fate commitment inferred from mutant phenotype (Monier et al., 2005) ecdysis, chitin-based cuticle inferred from mutant phenotype (Li and Bender, 2000) ecdysone receptor-mediated signaling pathway inferred from mutant phenotype (Li and Bender, 2000) epidermis development inferred from mutant phenotype (Ninov et al., 2007) germ-band shortening inferred from mutant phenotype (Kozlova and Thummel, 2003) germ cell development inferred from mutant phenotype (König et al., 2011) hatching inferred from mutant phenotype (Li and Bender, 2000) head involution inferred from mutant phenotype (Kozlova and Thummel, 2003) histoblast morphogenesis inferred from mutant phenotype (Ninov et al., 2007) imaginal disc-derived wing morphogenesis inferred from genetic interaction with if AND inferred from genetic interaction with mys AND inferred from mutant phenotype (D'Avino and Thummel, 2000) larval central nervous system remodeling inferred from mutant phenotype (Tomita et al., 2003, Brown and Truman, 2009) larval wandering behavior inferred from mutant phenotype (Davis et al., 2005) long-term memory inferred from mutant phenotype (Ishimoto et al., 2009) Malpighian tubule morphogenesis inferred from mutant phenotype (Gautam and Tapadia, 2010) metamorphosis inferred from mutant phenotype (Li and Bender, 2000) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) mushroom body development inferred from genetic interaction with Smox AND inferred from genetic interaction with babo (Zheng et al., 2003) negative regulation of growth of symbiont in host inferred from mutant phenotype (Koo et al., 2008) neuron development inferred from mutant phenotype (Parrish et al., 2006) neuron remodeling inferred from mutant phenotype (Lee et al., 2000, Awasaki and Ito, 2004, Roy et al., 2007) oogenesis inferred from mutant phenotype (Carney and Bender, 2000) peripheral nervous system development inferred from mutant phenotype (Schubiger et al., 2005) positive regulation of apoptosis inferred from mutant phenotype (Sprecher and Desplan, 2008) positive regulation of circadian sleep/wake cycle, sleep inferred from mutant phenotype (Ishimoto and Kitamoto, 2010) pupariation inferred from mutant phenotype (Li and Bender, 2000, Davis et al., 2005) regulation of Malpighian tubule diameter inferred from mutant phenotype (Gautam and Tapadia, 2010) regulation of rhodopsin gene expression inferred from mutant phenotype (Sprecher and Desplan, 2008) regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (D'Avino and Thummel, 2000) response to cocaine inferred from genetic interaction with InR (Willard et al., 2006) spermatid development inferred from mutant phenotype (Castrillon et al., 1993) sperm individualization inferred from mutant phenotype (Fabrizio et al., 1998)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Brennan et al., 2001) dendrite inferred from mutant phenotype (Kuo et al., 2005) ecdysone receptor holocomplex inferred from physical interaction with usp (Zelhof et al., 1995) nucleus inferred from direct assay (Talbot et al., 1993, Carney and Bender, 2000, Koelle et al., 1991) repressor ecdysone receptor complex inferred from physical interaction with alien (Dressel et al., 1999)
Terms Based on Predictions or Assertions ( 17 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Kozlova and Thummel, 2000, Swiss-Prot Project Members, 1994.2.1) ecdysteroid hormone receptor activity non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) ligand-dependent nuclear receptor activity non-traceable author statement (Maglich et al., 2001) traceable author statement (Gibson and Schubiger, 2001) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001628 (FlyBase Curators et al., 2004-) steroid binding inferred from electronic annotation with InterPro:IPR003069 (FlyBase Curators et al., 2004-) non-traceable author statement (Kozlova and Thummel, 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
dendrite morphogenesis non-traceable author statement (Grueber and Jan, 2004) ecdysone-mediated induction of salivary gland cell autophagic cell death non-traceable author statement (Buszczak and Segraves, 2000) imaginal disc eversion traceable author statement (Gibson and Schubiger, 2001) larval central nervous system remodeling traceable author statement (Tissot and Stocker, 2000) negative regulation of transcription, DNA-dependent traceable author statement (Kozlova and Thummel, 2000) oogenesis non-traceable author statement (Kozlova and Thummel, 2000) regulation of development, heterochronic traceable author statement (Thummel, 2001) steroid hormone mediated signaling pathway inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR008946 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
ecdysone receptor holocomplex traceable author statement (Buszczak and Segraves, 2000) nucleus non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1994.2.1) polytene chromosome non-traceable author statement (Kozlova and Thummel, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions EcR allele Gene References EcR318 Dfd (Gellon et al., 1997) EcRB1.Scer\UAS babo (Zheng et al., 2003) EcRB1-ΔC655.F645A.Scer\UAS Smr (Sedkov et al., 2003, Sedkov et al., 2003) trr (Sedkov et al., 2003, Sedkov et al., 2003) EcRB1-ΔC655.W650A.Scer\UAS Pten (Rusten et al., 2004) EcRC284Y Hsc70-4 (Arbeitman and Hogness, 2000) EcRC300Y Hsc70-4 (Arbeitman and Hogness, 2000) if (D'Avino and Thummel, 2000) mys (D'Avino and Thummel, 2000) Sin3A (Bodai, 2000.12.22) EcRD491N Hsc70-4 (Arbeitman and Hogness, 2000) EcRE261st Sin3A (Tsai et al., 1999) EcRhs.T:Scer\GAL4 mys (Kozlova and Thummel, 2003) EcRk06210 trr (Sedkov et al., 2003) EcRM554fs if (D'Avino and Thummel, 2000) mys (D'Avino and Thummel, 2000) trr (Sedkov et al., 2003) unspecified E(bx) (Badenhorst et al., 2005) G9a (Stabell et al., 2006) Iswi (Badenhorst et al., 2005) Lam (Osouda et al., 2005) Nurf-38 (Badenhorst et al., 2005) Pc (Gellon et al., 1997) Set2 (Stabell et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61444 DroID - A comprehensive database of gene and protein interactions. • FBgn0000546 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35540
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13818 Dere\GG10830 Dgri\GH20948 Dmoj\GI21285 Dper\GL16258 Dsec\GM16480 Dsim\GD10334 Dvir\GJ20887 Dwil\GK21996 Dyak\GE19426
Curated drosophilid orthologs	Dmir\EcR   Dpse\EcR
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009600-PA Aedes aegypti (mosquito) AGAP012211-PA Anopheles gambiae (mosquito) XP_394760.3 Apis mellifera (honey bee) XP_001942667.1 Acyrthosiphon pisum (pea aphid) 128090 Branchiostoma floridae (lancelet) ENSBTAP00000014131 Bos taurus (bovine) CE31141 Caenorhabditis elegans (worm) ENSCAFP00000012970 Canis familiaris (dog) CPIJ002963 Culex pipens (mosquito) ENSECAP00000018458 Equus caballus (horse) ISCW003147-PA Ixodes scapularis (deer tick) ENSPTRP00000053041 Pan troglodytes (chimpanzee) NP_001107650.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11088 ISCW003147 FBgn0236769 FBgn0223981 FBgn0208023 FBgn0182106 FBgn0171395 JGI_V11_319648 FBgn0245500 FBgn0243551 FBgn0153862 FBgn0144015 FBgn0128410 FBgn0103135 FBgn0090845 CPIJ002963 BGIBMGA006767 ACYPI001692 GB30298 AGAP012211 ECR_AEDAE PHUM467460 GLEAN_12113 GLEAN_12112
Stocks & Reagents
Stocks Listed in FlyBase ( 77 )
Bloomington	4895 EcRQ50st/SM6b 4894 EcRM554fs/SM6b
Harvard	- P{XP}EcRd00918 - P{XP}EcRd03255 - P{XP}EcRd08765 - PBac{PB}EcRc01365 - PBac{PB}EcRc02091 - PBac{PB}EcRc02192 - PBac{PB}EcRc03719
Kyoto	107935 EcRQ50st/SM6b 108328 EcRW53st/SM6a 107934 EcRM554fs/SM6b
	More stocks available...
Genomic Clones ( 3 )
	BACR08A11 BACR13P06 BACR39E09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 202 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD26915 LD46618 RE06878 RE16656 RE33854
Other clones	DPiM_RE33854
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL01604 LD02196 LD03950 LD05168 LD06221 LD10132 LD10250 LD13085 LD17664 LD18219 LD20681 LD21629 LD25391 LD25468 LD30566 LD33726 LD33832 LD37214 LD40566 LD40781 LD43136 LD45263 LD46649 LD47647 LP01848 RE02495 RE07057 RE08182 RE11827 RE22343 RE34511 RE38758 RE42102 RE60784 RE69229 RE71451 SD16866
Other clones	12631 17717 37495 41573 51151 53524 58316 77274 79350 79384 81390 103437 106693 109022 121592 123123 124962 147095 152980 163139 164967 173071 176590 214539.51 280798 bs50e02 CK01.14A.H2 CK01.36A.E9 CK01.53D.C6 CK01.54A.H5 CK01.60A.E3 CK01.61A.E12 CK01.103A.C6 CK01.103A.E10 CK01.107B.D3 CK01.142A.A6 EC27888 EK043443 EK047314 EK057604 EK063850 EK113751 EK150061 EK154759 EK158619 EK180855 EK208926 EK232623 EK241958 EK243218 EK247264 EK249613 EK252008 EK256533 EK263660 EK267144 EK272754 EK281252 EK305555 ESG017c.E21.3_F08 RP004035127 RP004043262 RP004048952 RP004054850 RP004061427 RP004064637 RP004080702 RP004081954 RP004093222 RP004107017 RP004113028 RP004116803 RP004118464 RP004118892 RP004129715 RP004139240 RP004150480 RP004157835 RP004159247 RP004159912 RP004171156 RP004172761 RP004185100 RP004190756 RP004198846 RP004200537 RP004203228 RP004203444 RP004207904 RP004209048 RP004209409 RP004214367 RP004218961 RP004222669 RP004223185 RP004224157 RP004224650 RP004229793 RP004231094 RP004234779 RP004235828 RP004244556 RP004249738 RP004252785 RP004252901 RP004264697 RP004265255 RP004266041 RP004314763 RP004322608 RP004338283 RP004338474 RP004340022 RP004349030 RP004362791 RP004369568 RP004375743 RP004400391 RP004406671 RP004412427 RP004420024 RP004421355 RP004423909 RP004424377 RP004437663 RP004438315 RP004442544 RP004448238 RP004451668 RP004458220 RP004467213 RP004468502 RP004470046 RP004470195 RP004470678 RP004471457 RP004471471 RP004473924 RP004474414 RP004474761 RP004476057 RP004483504 RP004483546 RP004491118 RP004502523 RP004503470 RP004508851 RP004512184 RP004514899 RP004521213 RP004526128 RP004529976 RP004530663 RP004539063 RP004541041 RP004553383 RP004553435 RP004553625 RP004558360
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000546 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35540
Antibody Information
	monoclonal (Talbot et al., 1993, Schwedes et al., 2011, Talbot et al., 1993, Talbot et al., 1993) monoclonal, polyclonal (Koelle et al., 1991) polyclonal (Kirilly et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: EcR CG1765 (Kodira, 1999.11)
Source for database merge of	Source for merge of: EcR anon-WO0229075.1 (FlyBase, 1996-) Source for merge of: EcR CG8347 (Levis, 2004.3.9) Source for merge of: EcR lie (Levis, 2004.3.9) Source for merge of: snt EcR (Florence and McGinnis, 1998)
Additional comments	Source for merge of EcR anon-WO0229075.1 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for EcR protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) The EcR-A isoform is not a signal transducer for programmed cell death in Crz-expressing ventral nerve cord neurons. EcR-B isoforms play significant roles in Crz-expressing ventral nerve cord neuron cell death. (Choi et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. RNAi of EcR reduces the primary dendrite outgrowth of ddaD and ddaE neurons, but causes only modest reduction of lateral branching and lateral branch outgrowth. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) ChEST reveals this is a target of Mef2. (Junion et al., 2005) Ecdysone signalling cell-autonomously downregulates PI3K activity in the fat body. (Rusten et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) babo/Smox mediated TGFΒ/Activin signalling mediates remodeling of mushroom body neurons via controlling EcR-B1 expression. (Zheng et al., 2003) EcR is not required for morphogenetic furrow formation in the developing eye. (Brennan et al., 2001) The EcR/usp heterodimer DNA binding activity requires activation by a chaperone heterocomplex of six proteins including the products of Hsp83 and the Hsc70 genes. The gene products of Hsp83 and the Hsc70 genes are also required in vivo for EcR activity and EcR is the primary target of the chaperone complex. (Arbeitman and Hogness, 2000) Genetic interaction between EcRE261st and Sin3Ak07401 reported in FBrf0111507 is not evident when EcRC300Y is combined with Sin3A08269, suggesting that the original observed interaction could be due to background effects. (Bodai, 2000.12.22) EcR function is required maternally for normal oogenesis. (Carney and Bender, 2000) EcR together with crol controls wing morphogenesis and cell adhesion by regulating integrin expression during metamorphosis. (D'Avino and Thummel, 2000) EcR has a cell autonomous role in controlling neuronal remodelling. (Lee et al., 2000) EcR is required for hatching, at each larval moult and for the initiation of metamorphosis. (Li and Bender, 2000) EcR/usp may play an essential role as a hormonal timer. (Brodu et al., 1999) The ng-EcRE, located within the coding region of ng1 and ng2, binds the EcR/usp heterodimer through its widely spaced half sites. (Crispi et al., 1998) Binding site selection procedure demonstrates that the EcR/usp heterodimer binds to the core recognition motif (consensus sequence consists of a perfect palindrome of the heptameric half-site sequence GAGGTCA that is separated by a single A/T base pair). (Vogtli et al., 1998) Mutations in EcR reveal functional differences among the receptor isoforms encoded by the EcR gene. (Bender et al., 1997) Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Mutants weakly interact with Pc. (Gellon et al., 1997) The EcR/usp heterodimer binds in vitro to direct repeats and these repeats can confer ecdysteroid responsiveness on minimal promoters in a cell transfection assay. The natural pseudopalindromic EcR/usp binding site in the Fbp1 enhancer is required to mediate a fat body-specific ecdysteroid response. The profound differences in structure between these two types of EcR/usp binding site do not dictate a spatial and temporal specificity of the transcriptional response they mediate. (Antoniewski et al., 1996) Interaction of the DNA binding domain with a 20-hydroxyecdysone palindromic response element from the promoter region of Hsp27 has been studied. (Rusin et al., 1996) DNA-blotting assay has identified a high affinity ecdysone receptor binding site within the ng1 and ng2 coding sequence. EMSA assay demonstrates the 93bp 'ng element' is able to bind an EcR/usp heterodimer and usp alone. (D'Avino et al., 1995) Expression throughout the onset of metamorphosis is not affected by Eip74EF mutations. (Fletcher and Thummel, 1995) EcR and usp interact as a dimer. (Horner et al., 1995) The usp product acts as an allosteric effector to enhance steroid binding by the EcR product. Under some conditions, DNA binding by EcR/usp product is highly steroid-dependent. (Hu et al., 1995) The EcR product binds to two sites, element I and element II, in the regulatory region of Sgs4. Element II appears to be of no importance for the expression of Sgs4 while element I is an ecdysone response element necessary, but not sufficient, for Sgs4 induction. (Lehmann and Korge, 1995) EcR has been stably transfected into CHO cells. Nuclear extracts from the line exhibit specific binding activity for the Hsp27 ecdysone response element in mobility shift analyses. (Yang et al., 1995) The in vitro characterisation of the EcR/usp binding site its ecdysone- dependent in vivo occupancy in different genetic backgrounds support the conclusion that the Fbp1 enhancer is a primary target of the EcR. (Antoniewski et al., 1994) Neurons show qualitative and quantitative changes in EcR expression during their life history and these differences correlate with distinct patterns of ecdysteroid response. (Truman et al., 1994) Ecdysteroid-regulated gene. (Andres et al., 1993) Postmeiotic differentiation defect. (Castrillon et al., 1993) The correlation of a unique pattern of ecdysone receptor isoform A expression in the CNS of the emerging adult with a particular steroid regulated cell death fate suggests that variations in the pattern of receptor isoform expression may serve as important switches during development. (Robinow et al., 1993) The ecdysone receptor gene encodes three receptor isoforms with common DNA and hormone binding domains but different N-terminal regions. Different isoforms predominate at different developmental stages that are marked by a pulse of ecdysone. (Talbot et al., 1993) Transient cotransfection experiments in HeLa cells demonstrated that EcR must heterodimerize with usp (the homolog of the mammalian retinoid X receptor) for DNA binding and transactivation. EcR/usp gene product DNA binding activity is unaffected by ecdysteroid and 9-cis-retinoic acid. (Thomas et al., 1993) EcR and usp native gene products co-localise on ecdysone-responsive loci. Physical associations in the presence and absence of ecdysone redefine the ecdysone receptor as a dynamic complex whose activity may be altered by combinatorial interactions among subunits and ligand. (Yao et al., 1993) EcR protein can function as a ligand-dependent transcription factor in mammalian cells. (Christopherson et al., 1992) Cotransfection of both usp and EcR is required to render cultured mammalian cells ecdysone responsive. (Yao et al., 1992) usp is a Drosophila partner of EcR. Together usp and EcR bind DNA in a highly cooperative pattern. (Yao et al., 1992) Identification: EcR was identified in a screen for members of the steroid receptor superfamily. (Koelle et al., 1991) The DNA binding properties of the ecdysone receptor protein have been defined. In vitro binding studies demonstrate that ecdysterone causes activation or repression of the receptor DNA binding domain via an irreversible change in conformation. (Luo et al., 1991) EcR binds as a dimer to an imperfect palindromic sequence (GGTTCAATGCACT) in the Hsp27 promoter region. (Ozyhar et al., 1991) The effect of pyridoxal 5'-phosphate on the binding of EcR from a nuclear extract to DNA-cellulose is studied: application inhibits EcR binding to DNA. (Ozyhar et al., 1990) A novel bromoacetly ecdysteroid IV reacts with partially purified EcR rapidly and almost quantitatively. (Strangmann-Diekmann et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165461 NM_165462 NM_165463 NM_165464 NM_165465 NM_001169590 RefSeq (Proteins) • NP_724456 NP_724457 NP_724458 NP_724459 NP_724460 NP_001163061 DDBJ / EMBL / GenBank • AA539503 AAA28498 AAB27496 AAF57278 AAF57280 AAG22334 AAL13804 AAL68274 AAM68346 AAM68347 AAT94463 ACZ94341 AI520584 AQ025786 AQ026415 AQ073646 AX407008 AY058575 AY075461 BH011418 BH759480 BI230982 BI237603 BT015234 BZ286306 CL525863 CZ467670 CZ467758 CZ468804 CZ468960 CZ468983 CZ471893 CZ476085 CZ476400 CZ478924 CZ481520 CZ481521 CZ483792 CZ483793 CZ484679 CZ484779 CZ484780 CZ486449 CZ486853 CZ486854 CZ490259 M74078 S63761 S63762 Entrez Gene - A searchable database of RefSeq genes. • 35540 UniProtKB/Swiss-Prot • P34021 UniProtKB/TrEMBL • A4UZ51 E1JGY2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nuclear hormone receptor, ligand-binding, core (IPR000536) Zinc finger, nuclear hormone receptor-type (IPR001628) Steroid hormone receptor (IPR001723) Ecdysteroid receptor (IPR003069) Nuclear hormone receptor, ligand-binding (IPR008946) Zinc finger, NHR/GATA-type (IPR013088)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61444 DroID - A comprehensive database of gene and protein interactions. • FBgn0000546 DRSC - Results from RNAi screens. • FBgn0000546 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000546 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1765-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000546 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35540 InParanoid A subset of ortholog calls from InParanoid. • AAEL009600-PA Aedes aegypti (mosquito) AGAP012211-PA Anopheles gambiae (mosquito) XP_394760.3 Apis mellifera (honey bee) XP_001942667.1 Acyrthosiphon pisum (pea aphid) 128090 Branchiostoma floridae (lancelet) ENSBTAP00000014131 Bos taurus (bovine) CE31141 Caenorhabditis elegans (worm) ENSCAFP00000012970 Canis familiaris (dog) CPIJ002963 Culex pipens (mosquito) ENSECAP00000018458 Equus caballus (horse) ISCW003147-PA Ixodes scapularis (deer tick) ENSPTRP00000053041 Pan troglodytes (chimpanzee) NP_001107650.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/ecdysonr.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35540 modMine - Data generated by the modENCODE project. • FBgn0000546 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11088 ISCW003147 FBgn0236769 FBgn0223981 FBgn0208023 FBgn0182106 FBgn0171395 JGI_V11_319648 FBgn0245500 FBgn0243551 FBgn0153862 FBgn0144015 FBgn0128410 FBgn0103135 FBgn0090845 CPIJ002963 BGIBMGA006767 ACYPI001692 GB30298 AGAP012211 ECR_AEDAE PHUM467460 GLEAN_12113 GLEAN_12112 REDfly - A database of transcriptional regulatory elements. • FBgn0000546
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	anon-WO0229075.1   CG1765 (Fulton et al., 2001, Quinones-Coello, 2007, Sala et al., 2011, Perkins et al., 2009) CG8347 (Luschnig, 2003.12.17, ) DEcR (Martinez et al., 1999) dECR (Laudet and Adelmant, 1995) Dhr23   DmEcR (Bitra and Palli, 2009, Dinan et al., 2001, Henrich and Brown, 1995, Hoppe et al., 2000, Dhadialla et al., 2007, Li et al., 2007) dmEcR (Harada et al., 2009) EcdR (Ozyhar et al., 1991) EcR (Baker and Russell, 2009, Beatty et al., 2009, Warren et al., 2006, Nagalakshmi et al., 2007, Hackney et al., 2007, Necakov et al., 2007, Johnston et al., 2007, Petruk et al., 2006, Lovato et al., 2005, Moorman et al., 2006, Palanker et al., 2006, Parrish et al., 2006, King-Jones and Thummel, 2005, Takaesu et al., 2006, Blanco et al., 2010, Hoopfer et al., 2008, Grebe et al., 2004, Bernardi et al., 2007, Romani et al., 2007, Monnier et al., 2007, Baker et al., 2007, Thummel, 2007.4, Stabell et al., 2006, Nurminsky, 2007, Chavoshi et al., 2010, Zhao et al., 2008, Shi et al., 2007, Christensen et al., 2007.10.29, Stabell et al., 2007, Quinones-Coello, 2007, Rendina et al., 2010, Ninov et al., 2007, Akdemir et al., 2006, Sun et al., 2008, Schwedes and Carney, 2008, Bernardo et al., 2008, Costantino et al., 2008, Hackney and Dobens, 2008, Weake et al., 2008, Williams and Truman, 2005, Maki et al., 2004, Roesijadi et al., 2007, Dutko-Gwóźdź et al., 2008, Kimura et al., 2008, de la Cruz et al., 2000, Varghese and Cohen, 2007, Wang et al., 2010, Zeitouni et al., 2007, Hackney et al., 2007, Bashirullah et al., 2007, Costantino et al., 2008, McBrayer et al., 2007, Pauli et al., 2008, Schuldiner et al., 2008, Yin et al., 2007, Cakouros et al., 2008, Sun et al., 2008, Kim et al., 2007, Petruk et al., 2008, Ng, 2008, Awasaki et al., 2006, Romani et al., 2009, Mitchell et al., 2008, Sprecher and Desplan, 2008, Bergman et al., 2004, Saleh et al., 2009, Chittaranjan et al., 2009, Pile et al., 2002, Bernardo et al., 2009, Maeder et al., 2009, Jang et al., 2009, Ninov et al., 2009, Lee et al., 2009, Ishimoto et al., 2009, Pentek et al., 2009, Carrera et al., 2008, Azoitei and Spindler-Barth, 2009, Bernardi et al., 2009, Liu et al., 2009, Mirth et al., 2009, Flatt et al., 2008, Beatty et al., 2006, Liu and Lehmann, 2008, Soin et al., 2008, Slaidina et al., 2009, Okamoto et al., 2009, Harada et al., 2009, Nocula-Ługowska et al., 2009, Tricoire et al., 2009, Tolhuis et al., 2006, Dobryszycki et al., 2006, Boyle and Berg, 2009, Brown and Truman, 2009, Kirilly et al., 2009, Dalton et al., 2009, Lin et al., 2009, Fagegaltier et al., 2009, Liebl and Featherstone, 2005, Beckstead et al., 2005, Sawatsubashi et al., 2010, Ishimoto and Kitamoto, 2010, Delanoue et al., 2010, Curtis et al., 2007, van der Knaap et al., 2010, Cook and Cook, 2010.10.13, Cook and Cook, 2010.10.13, Wang et al., 2010, Rewitz et al., 2010, Liu et al., 2010, Garbuzov and Tatar, 2010, Gautam and Tapadia, 2010, Beltran et al., 2007, Tricoire et al., 2009, Li and Cooper, 2001, Roy et al., 2007, Wang et al., 2011, Fang et al., 2005, Krusiński et al., 2010, Goto et al., 2011, Terashima and Bownes, 2005, Francis et al., 2010, Ritter and Beckstead, 2010, König et al., 2011, Han et al., 2011, Betanska et al., 2011, Schwedes et al., 2011, Ganter et al., 2007, Dubrovsky et al., 2011) Ecr (Junion et al., 2005) ecr (Tissot and Stocker, 2000) ECR (Escriva et al., 1997, Flatt et al., 2005, Filion et al., 2010) EcR-A (Sung and Robinow, 2000, Robinow et al., 1997, McNabb et al., 1997, Ou et al., 2008) EcR-B (Choi et al., 2006) EcRB1 (Osouda et al., 2005, Marin et al., 2005, Moorman et al., 2006, Moorman et al., 2006, Hoopfer et al., 2008) EcR-B1 (Roman, 2004, Watts et al., 2003, Zheng et al., 2003, Zheng et al., 2003, Ou et al., 2008, Ting et al., 2007, Riddiford et al., 2010, Pauli et al., 2010, Boulanger et al., 2011) EcRB-1 (Gibson and Schubiger, 2001) lie (BDGP Project Members, 1994-1999, Fabrizio et al., 1998, ) ms(2)42A (Spradling et al., 1999, Castrillon et al., 1993, ) ms(2)06410   NR1H1 (Nuclear Receptors Nomenclature Committee, 1999, King-Jones and Thummel, 2005) snt (Gellon et al., 1997, )
Name Synonym	ecdysone receptor (Bitra and Palli, 2009, Baker and Russell, 2009, Beatty et al., 2009, Takeyama et al., 2002, Nagalakshmi et al., 2007, Flatt et al., 2005, Bai et al., 2000, Starz-Gaiano and Montell, 2004, D and Emerson, 2006, Schwedes and Carney, 2008, Costantino et al., 2008, Williams and Truman, 2005, Maki et al., 2004, Kimura et al., 2008, de la Cruz et al., 2000, Hoppe et al., 2000, Cakouros et al., 2008, Sun et al., 2008, Koo et al., 2008, Awasaki et al., 2006, Chittaranjan et al., 2009, Lee et al., 2009, Flatt et al., 2008, Beatty et al., 2006, Slaidina et al., 2009, Okamoto et al., 2009, Dobryszycki et al., 2006, Brown and Truman, 2009, Lin et al., 2009, Sawatsubashi et al., 2010, Curtis et al., 2007, Fang et al., 2005, Terashima and Bownes, 2005, Ganter et al., 2007, Dubrovsky et al., 2011) Ecdysone Receptor (Farkas and Mechler, 2001, Johnston et al., 2007, Hackney and Dobens, 2008, Hackney et al., 2007, Ishimoto et al., 2009) Ecdysone receptor (Willard et al., 2006, Bernardi et al., 2007, Arbouzova and McNeill, 2007, Zhao et al., 2008, Sprecher and Desplan, 2008, Roesijadi et al., 2007, Zeitouni et al., 2007, Sprecher and Desplan, 2008, Saleh et al., 2009, Jang et al., 2009, Bernardi et al., 2009, Boyle and Berg, 2009, Ishimoto and Kitamoto, 2010, Delanoue et al., 2010, van der Knaap et al., 2010, Pankotai et al., 2010, Ritter and Beckstead, 2010) ecdysteroid receptor (Nocula-Ługowska et al., 2009) ecdysterone receptor (Roy et al., 2007) long island expressway (Fabrizio et al., 1998, ) male sterile(2)42A   snaggletooth (Gellon et al., 1997, )
Secondary FlyBase IDs
	FBgn0011242 FBgn0021762 FBgn0033064 FBgn0062534
References ( 510 )
Generate a list of	All references relating to this gene ( 510 )
List References by type	Research paper  ( 289 ) Supplementary material  ( 11 ) Review  ( 53 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 118 ) FlyBase analysis  ( 5 ) Computer file  ( 4 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Letter  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Editorial  ( 3 ) Thesis  ( 1 )
Recent research papers ( 33 )
	Betanska et al., 2011, Arch. Insect Biochem. Physiol. 76(1): 12--21 The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor. [FBrf0212558] Bond et al., 2011, Dev. Biol. 360(2): 286--296 ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila. [FBrf0216600] Boulanger et al., 2011, Nat. Neurosci. 14(1): 37--44 ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling. [FBrf0212642] Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700 The Drosophila FTZ-F1 Nuclear Receptor Mediates Juvenile Hormone Activation of E75A Gene Expression through an Intracellular Pathway. [FBrf0215576] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Gradilla et al., 2011, Genetics 189(3): 871--883 Isoform-Specific Regulation of a Steroid Hormone Nuclear Receptor by an E3 Ubiquitin Ligase in Drosophila melanogaster. [FBrf0216551] Han et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(23): 9673--9678 Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. [FBrf0213916] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] König et al., 2011, EMBO J. 30(8): 1549--1562 Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. [FBrf0213531] Nakajima et al., 2011, Mol. Cell. Biol. 31(12): 2499--2512 Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila. [FBrf0213728] Parker and Shingleton, 2011, Dev. Biol. 357(2): 318--325 The coordination of growth among Drosophila organs in response to localized growth-perturbation. [FBrf0214795] Sala et al., 2011, EMBO J. 30(9): 1766--1777 Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. [FBrf0213629] Schwedes et al., 2011, J. Insect Physiol. 57(7): 899--907 Ecdysone receptor expression and activity in adult Drosophila melanogaster. [FBrf0214050] Wang et al., 2011, Dev. Biol. 351(1): 146--155 The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. [FBrf0212972] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Chavoshi et al., 2010, Mech. Dev. 127(5-6): 308--319 Tissue-autonomous EcR functions are required for concurrent organ morphogenesis in the Drosophila embryo. [FBrf0210781] Delanoue et al., 2010, Dev. Cell 18(6): 1012--1021 The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. [FBrf0211284] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Francis et al., 2010, Curr. Biol. 20(20): 1799--1808 dDOR Is an EcR Coactivator that Forms a Feed-Forward Loop Connecting Insulin and Ecdysone Signaling. [FBrf0212109] Garbuzov and Tatar, 2010, Fly 4(4): 306--311 Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity. [FBrf0212526] Gautam and Tapadia, 2010, Int. J. Dev. Biol. 54(4): 635--642 Ecdysone signaling is required for proper organization and fluid secretion of stellate cells in the Malpighian tubules of Drosophila melanogaster. [FBrf0210168] Ishimoto and Kitamoto, 2010, Genetics 185(1): 269--281 The Steroid Molting Hormone Ecdysone Regulates Sleep in Adult Drosophila melanogaster. [FBrf0210911] Krusiński et al., 2010, Nucleic Acids Res. 38(9): e108 Dual FRET assay for detecting receptor protein interaction with DNA. [FBrf0210789] Liu et al., 2010, J. Neurosci. 30(35): 11624--11634 Distinct Presynaptic and Postsynaptic Dismantling Processes of Drosophila Neuromuscular Junctions during Metamorphosis. [FBrf0211694] Pankotai et al., 2010, Mol. Cell. Biol. 30(17): 4254--4266 Genes of the Ecdysone Biosynthesis Pathway Are Regulated by the dATAC Histone Acetyltransferase Complex in Drosophila. [FBrf0211522] Pauli et al., 2010, Curr. Biol. 20(20): 1787--1798 A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. [FBrf0212124] Rewitz et al., 2010, Dev. Cell 19(6): 895--902 Steroid Hormone Inactivation Is Required during the Juvenile-Adult Transition in Drosophila. [FBrf0212489] Riddiford et al., 2010, Development 137(7): 1117--1126 A role for juvenile hormone in the prepupal development of Drosophila melanogaster. [FBrf0210225] Ritter and Beckstead, 2010, Dev. Dyn. 239(10): 2685--2694 Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis. [FBrf0212221] Sawatsubashi et al., 2010, Genes Dev. 24(2): 159--170 A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. [FBrf0209754] van der Knaap et al., 2010, Mol. Cell. Biol. 30(3): 736--744 Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes. [FBrf0209736] Wang et al., 2010, Dev. Dyn. 239(3): 954--964 Med24 and Mdh2 are required for Drosophila larval salivary gland cell death. [FBrf0210136] Wang et al., 2010, J. Mol. Cell. Biol. 2(3): 128--138 20-hydroxyecdysone reduces insect food consumption resulting in fat body lipolysis during molting and pupation. [FBrf0210866] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...