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Gene Dmel\Edg78E

General Information
Symbol	Dmel\Edg78E	Species	D. melanogaster
Name	Ecdysone-dependent gene 78E	Annotation symbol	CG7673
Feature type	protein_coding_gene	FlyBase ID	FBgn0000551
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Edg78
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	78C6-78C6	Sequence location	3L:21,289,863..21,290,903 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ecdysone-dependent gene 78E is referred to in FlyBase by the symbol Dmel\Edg78E (CG7673, FBgn0000551). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of chitin-based cuticle. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Insect cuticle protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1627026_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Edg78E. Gene sequence location is 3L:21289863..21290903.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN26712 HFA11863
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78C6-78C6   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 78E-78E   (determined by in situ hybridisation)   (Fechtel et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Edg78E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Edg78E-RA FBtr0078408  NM_079474   967   122
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Edg78E-PA   FBpp0078062   13.3   122   4.48     NP_524198   AAF51702
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF51702   AI259956   BT122122   M71247 AAA28499   M71248 AAA28500
UniProtKB/Swiss-Prot	P27779
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference prepupal stage   epidermis   (Fechtel et al., 1989)
Additional Descriptive Data
	Edg78E transcripts are present in equal abundance in imaginal and larval epidermis. Transcripts are detected in 8hr pupae and reach maximal accumulation in 10hr prepupae. None are detectable in 0-6hr prepupae or 14hr pupae. (Fechtel et al., 1989)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000551    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000551 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000551 expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr    1732 embryo 18-20hr    6102 embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr    385041 white prepupae 24hr    6319 pupae 2d postWPP    13317 pupae 3d postWPP    3740 pupae 4d postWPP    5584 adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr  (193) embryo 16-18hr  (1732) embryo 18-20hr  (6102) embryo 20-22hr  (855) embryo 22-24hr  (712) larva L1  (190) larva L2  (316) larva L3 12hr old  (1202) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new  106 white prepupae 12hr  (385041) white prepupae 24hr  (6319) pupae 2d postWPP  (13317) pupae 3d postWPP  (3740) pupae 4d postWPP  (5584) adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr  (1732) embryo 18-20hr  (6102) embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr  (385041) white prepupae 24hr  (6319) pupae 2d postWPP  (13317) pupae 3d postWPP  (3740) pupae 4d postWPP  (5584) adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr    1732 embryo 18-20hr    6102 embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr  (385041) white prepupae 24hr    6319 pupae 2d postWPP  (13317) pupae 3d postWPP    3740 pupae 4d postWPP    5584 adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr    1732 embryo 18-20hr    6102 embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr    385041 white prepupae 24hr    6319 pupae 2d postWPP    13317 pupae 3d postWPP    3740 pupae 4d postWPP    5584 adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000551 expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr    1732 embryo 18-20hr    6102 embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr    385041 white prepupae 24hr    6319 pupae 2d postWPP    13317 pupae 3d postWPP    3740 pupae 4d postWPP    5584 adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr  (193) embryo 16-18hr  (1732) embryo 18-20hr  (6102) embryo 20-22hr  (855) embryo 22-24hr  (712) larva L1  (190) larva L2  (316) larva L3 12hr old  (1202) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new  106 white prepupae 12hr  (385041) white prepupae 24hr  (6319) pupae 2d postWPP  (13317) pupae 3d postWPP  (3740) pupae 4d postWPP  (5584) adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr  1732 embryo 18-20hr  (6102) embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr  (385041) white prepupae 24hr  (6319) pupae 2d postWPP  (13317) pupae 3d postWPP  (3740) pupae 4d postWPP  (5584) adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr    1732 embryo 18-20hr    6102 embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr  (385041) white prepupae 24hr    6319 pupae 2d postWPP  13317 pupae 3d postWPP    3740 pupae 4d postWPP    5584 adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    46 embryo 04-06hr    19 embryo 06-08hr    14 embryo 08-10hr    21 embryo 10-12hr    49 embryo 12-14hr    36 embryo 14-16hr    193 embryo 16-18hr    1732 embryo 18-20hr    6102 embryo 20-22hr    855 embryo 22-24hr    712 larva L1    190 larva L2    316 larva L3 12hr old    1202 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    47 white prepupae new    106 white prepupae 12hr    385041 white prepupae 24hr    6319 pupae 2d postWPP    13317 pupae 3d postWPP    3740 pupae 4d postWPP    5584 adult male 01day    25 adult male 05day    30 adult male 30day    63 adult female 01day    8 adult female 05day    2 adult female 30day    2 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000551    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000551 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000551 expression level Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000551 expression level Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland no informative data Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland no informative data Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.6   NA  Eye    4.875   NA  Brain    6.5   6.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    6.4   6.4  Midgut    3.3   5.5  Hindgut    6.3   9.1  Malpighian Tubules    5.7   6.2  Fat Body    21.1   no informative data  Salivary Gland    no informative data   NA  Heart    5.225   5.25  Trachea    NA   NA  VirginFemale Spermatheca    9.7   NA  InseminatedFemale Spermatheca    6.8   NA  Ovary    2.5   NA  Testis    5   NA  Male Accessory Gland    no informative data   21.45  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_12
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000551 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7673-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Edg78EGD6772 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Edg78E Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Edg78E Class Mutagen Stocks Known lesion Edg78EGD6772 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Edg78EKK106712 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6772} NA P{KK106712} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
structural constituent of chitin-based cuticle inferred from sequence or structural similarity with InterPro:IPR000618 (Willis, 2007.1.3) inferred from sequence or structural similarity with Pfam:PF00379 (Willis, 2007.1.3) structural constituent of pupal chitin-based cuticle non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1992.8.1) traceable author statement (Andres et al., 1993)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Edg78E allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65602 DroID - A comprehensive database of gene and protein interactions. • FBgn0000551 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40354
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24202 Dere\GG13245 Dgri\GH16160 Dmoj\GI13312 Dper\GL24590 Dpse\GA20516 Dsec\GM22150 Dsim\GD12126 Dvir\GJ12082 Dwil\GK20425 Dyak\GE22345
Curated drosophilid orthologs	Dmau\Edg78E (Tao et al., 2003, Tao et al., 2003) Dpse\GA20516   Dsim\Edg78E (Tao et al., 2003, Tao et al., 2003)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0239921 FBgn0239568 FBgn0239014 FBgn0239013 FBgn0222422 FBgn0219777 FBgn0200364 FBgn0199334 FBgn0185949 FBgn0185950 FBgn0183863 FBgn0180093 FBgn0180092 FBgn0177021 FBgn0080510 FBgn0074926 FBgn0162179 FBgn0159475 FBgn0136069 FBgn0135751 FBgn0036109 FBgn0036108 FBgn0123631 FBgn0122860 FBgn0107709 FBgn0107707 FBgn0105517 FBgn0101196 FBgn0087656 FBgn0087657 CPIJ008833 CPIJ008834 CPIJ008835 CPIJ019804 BGIBMGA012603 BGIBMGA007015 CPR13 CPR12 CPR11 AAEL008873 AAEL008294 AAEL008295 AAEL008284 AAEL008288 AAEL004674 GLEAN_03834
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v107367 P{KK106712}VIE-260B v31133 w1118; P{GD6772}v31133 v31132 w1118; P{GD6772}v31132/CyO
Genomic Clones ( 1 )
	BACR02C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	FI14131
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP03489
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000551 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40354
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Temporal profile of gene expression is altered in Eip74EF mutant background. (Fletcher and Thummel, 1995) Premature expression of ftz-f1 induces the Edg78E and Edg84A genes which have strong ftz-f1 binding sites upstream of their transcription start sites. (Ueda et al., 1995) Ecdysteroid-regulated gene. (Andres et al., 1993) Initial characterization of Edg78E suggests the gene encodes a cuticle protein. (Apple and Fristrom, 1991) The spatial and temporal expression is as expected for genes that encode pupal cuticle proteins. (Fechtel et al., 1989) mRNA on Northerns: 0.6 kb Identification: Differential screen of a genomic library with cDNA isolated from imaginal discs pulsed with 20-hydroxyecdysone, 20-HE (Fechtel, Natzle, Brown and Fristrom, 1988). Transcripts in imaginal disc tissue, beginning at six to nine hours, following a six-hour 20-HE pulse, but not in the absence or continual presence of 20-HE; mRNA's enriched in membrane-bound polysome fractions of imaginal discs. Translation product from hybrid selected mRNA of Edg78E reacts with polyclonal antibodies prepared against purified pupal cuticle proteins.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079474 RefSeq (Proteins) • NP_524198 DDBJ / EMBL / GenBank • AAA28499 AAA28500 AAF51702 AAF51702.1 AI259956 M71247 M71248 Entrez Gene - A searchable database of RefSeq genes. • 40354 UniProtKB/Swiss-Prot • P27779
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65602 DroID - A comprehensive database of gene and protein interactions. • FBgn0000551 DRSC - Results from RNAi screens. • FBgn0000551 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000551 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7673-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000551 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40354 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40354 modMine - Data generated by the modENCODE project. • FBgn0000551 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0239921 FBgn0239568 FBgn0239014 FBgn0239013 FBgn0222422 FBgn0219777 FBgn0200364 FBgn0199334 FBgn0185949 FBgn0185950 FBgn0183863 FBgn0180093 FBgn0180092 FBgn0177021 FBgn0080510 FBgn0074926 FBgn0162179 FBgn0159475 FBgn0136069 FBgn0135751 FBgn0036109 FBgn0036108 FBgn0123631 FBgn0122860 FBgn0107709 FBgn0107707 FBgn0105517 FBgn0101196 FBgn0087656 FBgn0087657 CPIJ008833 CPIJ008834 CPIJ008835 CPIJ019804 BGIBMGA012603 BGIBMGA007015 CPR13 CPR12 CPR11 AAEL008873 AAEL008294 AAEL008295 AAEL008284 AAEL008288 AAEL004674 GLEAN_03834
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG7673 (Keleman et al., 2009.8.5) DmelEdg78E (Karouzou et al., 2007) DMLCP78 (Iconomidou et al., 1999) Edg78 (Bayer et al., 1996) EDG78 (Ueda et al., 1995, Apple and Fristrom, 1991) EDG-78 (Fristrom and Fristrom, 1993) Edg78e (Rifkin et al., 2003) EDG78E (Zhou and Riddiford, 2001, Kawasaki et al., 1998) Edg78E (Willis, 2007.1.3, Karouzou et al., 2007, Zhou and Riddiford, 2008, Blanco et al., 2010, Karouzou et al., 2007, Blanco et al., 2008, Beckstead et al., 2005)
Name Synonym	Ecdysone-dependent gene 78E
Secondary FlyBase IDs
	FBpp0078062 FBtr0078408
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...