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Gene Dmel\Edg78E

General Information
Symbol	Dmel\Edg78E	Species	D. melanogaster
Name	Ecdysone-dependent gene 78E	Annotation symbol	CG7673
Feature type	protein_coding_gene	FlyBase ID	FBgn0000551
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Edg78
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	78C6-78C6	Sequence location	3L:21,289,863..21,290,903 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ecdysone-dependent gene 78E is referred to in FlyBase by the symbol Dmel\Edg78E (CG7673, FBgn0000551). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of chitin-based cuticle. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Insect cuticle protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1627026_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Edg78E. Gene sequence location is 3L:21289863..21290903.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78C6-78C6   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 78E-78E   (determined by in situ hybridisation)   (Fechtel et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Edg78E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Edg78E-RA FBtr0078408  NM_079474   967   122
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Edg78E-PA   FBpp0078062   13.3   122   4.48     NP_524198   AAF51702
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF51702   AI259956   BT122122   M71247 AAA28499   M71248 AAA28500
UniProtKB/Swiss-Prot	P27779
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference prepupal stage   epidermis   (Fechtel et al., 1989)
Additional Descriptive Data
	Edg78E transcripts are present in equal abundance in imaginal and larval epidermis. Transcripts are detected in 8hr pupae and reach maximal accumulation in 10hr prepupae. None are detectable in 0-6hr prepupae or 14hr pupae. (Fechtel et al., 1989)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.9 Larval Midgut    6.4 Larval Hindgut    5.5 Larval Malpighian Tubules    9.1 Larval Fat Body    6.2 Larval Salivary Gland    10.7 Larval Trachea    5.25 Larval Carcass    21.45 Adult Head    5.6 Adult Eye    4.875 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    13 Adult Crop    6.4 Adult Midgut    3.3 Adult Hindgut    6.3 Adult Malpighian Tubules    5.7 Adult Fat Body    21.1 Adult Salivary Gland    24.2 Adult Heart    5.225 Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    6.8 Adult Ovary    2.5 Adult Testis    5 Adult Male Accessory Gland    12.6 Adult Carcass    11 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.6   NA  Eye    4.875   NA  Brain    6.5   6.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    6.4   6.4  Midgut    3.3   5.5  Hindgut    6.3   9.1  Malpighian Tubules    5.7   6.2  Fat Body    21.1   no informative data  Salivary Gland    no informative data   NA  Heart    5.225   5.25  Trachea    NA   NA  VirginFemale Spermatheca    9.7   NA  InseminatedFemale Spermatheca    6.8   NA  Ovary    2.5   NA  Testis    5   NA  Male Accessory Gland    no informative data   21.45  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    8 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr    80 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    5066 white prepupae 24hr    83 pupae 2d postWPP    175 pupae 3d postWPP    49 pupae 4d postWPP    73 adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr  (80) embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (5066) white prepupae 24hr  (83) pupae 2d postWPP  (175) pupae 3d postWPP  (49) pupae 4d postWPP  (73) adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr    80 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (5066) white prepupae 24hr    83 pupae 2d postWPP  (175) pupae 3d postWPP    49 pupae 4d postWPP    73 adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr    80 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    5066 white prepupae 24hr    83 pupae 2d postWPP    175 pupae 3d postWPP    49 pupae 4d postWPP    73 adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr    80 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    5066 white prepupae 24hr    83 pupae 2d postWPP    175 pupae 3d postWPP    49 pupae 4d postWPP    73 adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr  (80) embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (5066) white prepupae 24hr  (83) pupae 2d postWPP  (175) pupae 3d postWPP  (49) pupae 4d postWPP  (73) adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr    80 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (5066) white prepupae 24hr    83 pupae 2d postWPP  (175) pupae 3d postWPP    49 pupae 4d postWPP    73 adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    3 embryo 16-18hr    23 embryo 18-20hr    80 embryo 20-22hr    11 embryo 22-24hr    9 larva L1    3 larva L2    4 larva L3 12hr old    16 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    5066 white prepupae 24hr    83 pupae 2d postWPP    175 pupae 3d postWPP    49 pupae 4d postWPP    73 adult male 01day    0 adult male 05day    0 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_12
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000551 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7673-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Edg78EGD6772 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Edg78E Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Edg78E Class Mutagen Stocks Known lesion Edg78EGD6772 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Edg78EKK106712 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6772} NA P{KK106712} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
structural constituent of chitin-based cuticle inferred from sequence or structural similarity with InterPro:IPR000618 (Willis, 2007.1.3) inferred from sequence or structural similarity with Pfam:PF00379 (Willis, 2007.1.3) structural constituent of pupal chitin-based cuticle non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1992.8.1) traceable author statement (Andres et al., 1993)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Edg78E allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65602 DroID - A comprehensive database of gene and protein interactions. • FBgn0000551 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40354
Orthologs
OrthoDB Orthologs (265) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6321JR Dipteran inclusive ortholog search EOG6QZ7WD Insect inclusive ortholog search EOG6KKX13 Arthropod inclusive ortholog search EOG63R24R Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6321JR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Edg78E     Drosophila simulans   Dsim\GD12126 Y   Drosophila sechellia   Dsec\GM22150 Y   Drosophila erecta   Dere\GG13245 Y   Drosophila yakuba   Dyak\GE22345 Y   Drosophila yakuba   Dyak\GE22714     Drosophila ananassae   Dana\GF24202 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20516 Y   Drosophila persimilis   Dper\GL24590 Y   Drosophila willistoni   Dwil\GK20425 Y   Drosophila virilis   Dvir\GJ12082 Y   Drosophila mojavensis   Dmoj\GI13312 Y   Drosophila grimshawi   Dgri\GH16160 Y
Orthologs in non-Drosophila Dipterans (EOG6QZ7WD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008288 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008284 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004674 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010134 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008289 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010127 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014879 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008285 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008295 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008294 Y Anopheles gambiae Malaria mosquito  Agam\CPR106 Y Anopheles gambiae Malaria mosquito  Agam\CPR11 Y Anopheles gambiae Malaria mosquito  Agam\CPR12 Y Anopheles gambiae Malaria mosquito  Agam\CPR62 Y Anopheles gambiae Malaria mosquito  Agam\CPR15 Y Anopheles gambiae Malaria mosquito  Agam\CPR61 Y Anopheles gambiae Malaria mosquito  Agam\CPR12 Y Anopheles gambiae Malaria mosquito  Agam\CPR16 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008831 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019804 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019022 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012641 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008833 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008834 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008835 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008830 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011935 Y
Orthologs in non-Dipteran Insects (EOG6KKX13)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47906 Y Apis mellifera Western honey bee  Amel\LOC724649 Y Apis mellifera Western honey bee  Amel\CPR12 Y Apis mellifera Western honey bee  Amel\GB46298 Y Apis mellifera Western honey bee  Amel\GB52161 Y Apis mellifera Western honey bee  Amel\CPR13 Y Apis mellifera Western honey bee  Amel\GB47903 Y Apis mellifera Western honey bee  Amel\GB42612 Y Apis mellifera Western honey bee  Amel\GB43670 Y Apis mellifera Western honey bee  Amel\GB46297 Y Apis mellifera Western honey bee  Amel\GB47902 Y Apis mellifera Western honey bee  Amel\GB46312 Y Apis mellifera Western honey bee  Amel\GB46299 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006503 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006859 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005393 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006863 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013411 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013416 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006864 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010389 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010007 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006867 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016022 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013414 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013417 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007522 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006861 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010008 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006862 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013413 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22753 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22751 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17027 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17029 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21414 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19798 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22756 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17028 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22755 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21415 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21416 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22752 Y Atta cephalotes Leafcutter ant  Acep\ACEP25267 Y Atta cephalotes Leafcutter ant  Acep\ACEP27437 Y Atta cephalotes Leafcutter ant  Acep\ACEP24251 Y Atta cephalotes Leafcutter ant  Acep\ACEP17449 Y Atta cephalotes Leafcutter ant  Acep\ACEP27431 Y Atta cephalotes Leafcutter ant  Acep\ACEP25266 Y Atta cephalotes Leafcutter ant  Acep\ACEP24250 Y Atta cephalotes Leafcutter ant  Acep\ACEP27444 Y Atta cephalotes Leafcutter ant  Acep\ACEP27432 Y Atta cephalotes Leafcutter ant  Acep\ACEP25277 Y Atta cephalotes Leafcutter ant  Acep\ACEP24236 Y Atta cephalotes Leafcutter ant  Acep\ACEP25265 Y Atta cephalotes Leafcutter ant  Acep\ACEP27427 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21033 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14804 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21024 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21020 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20940 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15374 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20939 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21032 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21025 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20958 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21019 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21021 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14803 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14802 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21887 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21889 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20594 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20587 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19362 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20586 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19363 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20593 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20772 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19364 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21888 Y Linepithema humile Argentine ant  Lhum\LH23807 Y Linepithema humile Argentine ant  Lhum\LH19211 Y Linepithema humile Argentine ant  Lhum\LH16388 Y Linepithema humile Argentine ant  Lhum\LH16391 Y Linepithema humile Argentine ant  Lhum\LH19218 Y Linepithema humile Argentine ant  Lhum\LH16383 Y Linepithema humile Argentine ant  Lhum\LH10870 Y Linepithema humile Argentine ant  Lhum\LH24581 Y Linepithema humile Argentine ant  Lhum\LH24582 Y Linepithema humile Argentine ant  Lhum\LH16382 Y Linepithema humile Argentine ant  Lhum\LH24583 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20785 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14690 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18423 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14691 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18425 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14673 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20784 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14688 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20800 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24199 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14682 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20794 Y Solenopsis invicta Red fire ant  Sinv\SINV25632 Y Solenopsis invicta Red fire ant  Sinv\SINV21745 Y Solenopsis invicta Red fire ant  Sinv\SINV21730 Y Solenopsis invicta Red fire ant  Sinv\SINV25026 Y Solenopsis invicta Red fire ant  Sinv\SINV16553 Y Solenopsis invicta Red fire ant  Sinv\SINV21768 Y Solenopsis invicta Red fire ant  Sinv\SINV25020 Y Solenopsis invicta Red fire ant  Sinv\SINV25023 Y Solenopsis invicta Red fire ant  Sinv\SINV16530 Y Solenopsis invicta Red fire ant  Sinv\SINV21761 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009006 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI066082 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003649 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001610 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005591 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001775 Y Bombyx mori Silkmoth  Bmor\BmorCPR23 Y Bombyx mori Silkmoth  Bmor\BmorCPR39 Y Bombyx mori Silkmoth  Bmor\BmorCPR6 Y Bombyx mori Silkmoth  Bmor\BmorCPR33 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000340 Y Bombyx mori Silkmoth  Bmor\BmorCPR26 Y Bombyx mori Silkmoth  Bmor\BmorCPR37 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007015 Y Bombyx mori Silkmoth  Bmor\BmorCPR7 Y Bombyx mori Silkmoth  Bmor\BmorCPR24 Y Bombyx mori Silkmoth  Bmor\BmorCPR4 Y Bombyx mori Silkmoth  Bmor\BGIBMGA000341 Y Bombyx mori Silkmoth  Bmor\BmorCPR34 Y Bombyx mori Silkmoth  Bmor\BmorCPR27 Y Bombyx mori Silkmoth  Bmor\BmorCPR18 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002549 Y Bombyx mori Silkmoth  Bmor\BmorCPR38 Y Bombyx mori Silkmoth  Bmor\BmorCPR43 Y Bombyx mori Silkmoth  Bmor\BmorCPR42 Y Bombyx mori Silkmoth  Bmor\BmorCPR32 Y Bombyx mori Silkmoth  Bmor\BmorCPR49 Y Bombyx mori Silkmoth  Bmor\BmorCPR13 Y Bombyx mori Silkmoth  Bmor\BmorCPR9 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005277 Y Bombyx mori Silkmoth  Bmor\BmorCPR19 Y Pediculus humanus Human body louse  Phum\PHUM392770 Y Pediculus humanus Human body louse  Phum\PHUM605650 Y Pediculus humanus Human body louse  Phum\PHUM392750 Y Pediculus humanus Human body louse  Phum\PHUM605980 Y Pediculus humanus Human body louse  Phum\PHUM601840 Y Pediculus humanus Human body louse  Phum\PHUM606390 Y Pediculus humanus Human body louse  Phum\PHUM392730 Y Tribolium castaneum Red flour beetle  Tcas\TC013127 Y Tribolium castaneum Red flour beetle  Tcas\TC014500 Y Tribolium castaneum Red flour beetle  Tcas\TC014499 Y Tribolium castaneum Red flour beetle  Tcas\TC013131 Y Tribolium castaneum Red flour beetle  Tcas\TC014685 Y Tribolium castaneum Red flour beetle  Tcas\TC003831 Y Tribolium castaneum Red flour beetle  Tcas\TC013307 Y Tribolium castaneum Red flour beetle  Tcas\TC003834 Y Tribolium castaneum Red flour beetle  Tcas\TC013129 Y Tribolium castaneum Red flour beetle  Tcas\TC003832 Y Tribolium castaneum Red flour beetle  Tcas\TC014497 Y Tribolium castaneum Red flour beetle  Tcas\TC014770 Y Tribolium castaneum Red flour beetle  Tcas\TC013139 Y Tribolium castaneum Red flour beetle  Tcas\TC014771 Y Tribolium castaneum Red flour beetle  Tcas\TC013128 Y Tribolium castaneum Red flour beetle  Tcas\TC014498 Y Tribolium castaneum Red flour beetle  Tcas\TC014686 Y Tribolium castaneum Red flour beetle  Tcas\TC003830 Y Tribolium castaneum Red flour beetle  Tcas\TC003835 Y Tribolium castaneum Red flour beetle  Tcas\TC013138 Y Tribolium castaneum Red flour beetle  Tcas\TC004547 Y Tribolium castaneum Red flour beetle  Tcas\TC013130 Y Tribolium castaneum Red flour beetle  Tcas\TC013135 Y Tribolium castaneum Red flour beetle  Tcas\TC014720 Y Tribolium castaneum Red flour beetle  Tcas\TC002595 Y Tribolium castaneum Red flour beetle  Tcas\TC013126 Y Tribolium castaneum Red flour beetle  Tcas\TC004548 Y
Orthologs in non-Insect Arthropods (EOG63R24R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Map1d Y Daphnia pulex Water flea  Dpux\JGI_V11_253508 Y Daphnia pulex Water flea  Dpux\JGI_V11_58106 Y Daphnia pulex Water flea  Dpux\JGI_V11_263371 Y Daphnia pulex Water flea  Dpux\EF-1 alpha Y Daphnia pulex Water flea  Dpux\Psma3 Y Daphnia pulex Water flea  Dpux\MESK4 Y Daphnia pulex Water flea  Dpux\JGI_V11_60605 Y Daphnia pulex Water flea  Dpux\JGI_V11_303748 Y Daphnia pulex Water flea  Dpux\ycf9 Y Daphnia pulex Water flea  Dpux\Nktr Y Daphnia pulex Water flea  Dpux\JGI_V11_60650 Y Daphnia pulex Water flea  Dpux\JGI_V11_302740 Y Daphnia pulex Water flea  Dpux\JGI_V11_325416 Y Daphnia pulex Water flea  Dpux\PB2 Y Daphnia pulex Water flea  Dpux\JGI_V11_229448 Y Daphnia pulex Water flea  Dpux\JGI_V11_263370 Y Daphnia pulex Water flea  Dpux\JGI_V11_303733 Y Daphnia pulex Water flea  Dpux\JGI_V11_332302 Y Daphnia pulex Water flea  Dpux\JGI_V11_224365 Y Daphnia pulex Water flea  Dpux\JGI_V11_301237 Y Daphnia pulex Water flea  Dpux\Wbp4 Y Daphnia pulex Water flea  Dpux\JGI_V11_229447 Y Daphnia pulex Water flea  Dpux\CLDN25 Y Daphnia pulex Water flea  Dpux\ND1 Y Daphnia pulex Water flea  Dpux\JGI_V11_302183 Y Daphnia pulex Water flea  Dpux\JGI_V11_110014 Y Daphnia pulex Water flea  Dpux\mp20 Y Daphnia pulex Water flea  Dpux\JGI_V11_325539 Y Daphnia pulex Water flea  Dpux\JGI_V11_302739 Y Daphnia pulex Water flea  Dpux\JGI_V11_219079 Y Daphnia pulex Water flea  Dpux\Prc1 Y Daphnia pulex Water flea  Dpux\JGI_V11_109945 Y Daphnia pulex Water flea  Dpux\PB1-F2 Y Daphnia pulex Water flea  Dpux\JGI_V11_64995 Y Daphnia pulex Water flea  Dpux\JGI_V11_332314 Y Ixodes scapularis Deer tick  Isca\ISCW003132 Y Ixodes scapularis Deer tick  Isca\ISCW003791 Y Ixodes scapularis Deer tick  Isca\ISCW020944 Y Ixodes scapularis Deer tick  Isca\ISCW019775 Y Ixodes scapularis Deer tick  Isca\ISCW002954 Y Ixodes scapularis Deer tick  Isca\ISCW020943 Y Ixodes scapularis Deer tick  Isca\ISCW016302 Y Ixodes scapularis Deer tick  Isca\ISCW013798 Y Ixodes scapularis Deer tick  Isca\ISCW016310 Y Ixodes scapularis Deer tick  Isca\ISCW007107 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12126 Drosophila sechellia Dsec\GM22150 Drosophila erecta Dere\GG13245 Drosophila yakuba Dyak\GE22345 Drosophila ananassae Dana\GF24202 Drosophila pseudoobscura pseudoobscura Dpse\GA20516 Drosophila persimilis Dper\GL24590 Drosophila willistoni Dwil\GK20425 Drosophila virilis Dvir\GJ12082 Drosophila mojavensis Dmoj\GI13312 Drosophila grimshawi Dgri\GH16160
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v107367 P{KK106712}VIE-260B v31133 w1118; P{GD6772}v31133 v31132 w1118; P{GD6772}v31132/CyO
Genomic Clones ( 1 )
	BACR02C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	FI14131
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP03489
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000551 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40354
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Temporal profile of gene expression is altered in Eip74EF mutant background. (Fletcher and Thummel, 1995) Premature expression of ftz-f1 induces the Edg78E and Edg84A genes which have strong ftz-f1 binding sites upstream of their transcription start sites. (Ueda et al., 1995) Ecdysteroid-regulated gene. (Andres et al., 1993) Initial characterization of Edg78E suggests the gene encodes a cuticle protein. (Apple and Fristrom, 1991) The spatial and temporal expression is as expected for genes that encode pupal cuticle proteins. (Fechtel et al., 1989) mRNA on Northerns: 0.6 kb Identification: Differential screen of a genomic library with cDNA isolated from imaginal discs pulsed with 20-hydroxyecdysone, 20-HE (Fechtel, Natzle, Brown and Fristrom, 1988). Transcripts in imaginal disc tissue, beginning at six to nine hours, following a six-hour 20-HE pulse, but not in the absence or continual presence of 20-HE; mRNA's enriched in membrane-bound polysome fractions of imaginal discs. Translation product from hybrid selected mRNA of Edg78E reacts with polyclonal antibodies prepared against purified pupal cuticle proteins.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079474 RefSeq (Proteins) • NP_524198 DDBJ / EMBL / GenBank • AAA28499 AAA28500 AAF51702 AAF51702.1 AI259956 M71247 M71248 Entrez Gene - A searchable database of RefSeq genes. • 40354 UniProtKB/Swiss-Prot • P27779
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insect cuticle protein (IPR000618)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65602 DroID - A comprehensive database of gene and protein interactions. • FBgn0000551 DRSC - Results from RNAi screens. • FBgn0000551 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000551 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7673-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000551 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40354 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40354 modMine - Data generated by the modENCODE project. • FBgn0000551
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG7673 (Keleman et al., 2009.8.5) DmelEdg78E (Karouzou et al., 2007) DMLCP78 (Iconomidou et al., 1999) Edg78 (Bayer et al., 1996) EDG78 (Ueda et al., 1995, Apple and Fristrom, 1991) EDG-78 (Fristrom and Fristrom, 1993) Edg78e (Rifkin et al., 2003) EDG78E (Zhou and Riddiford, 2001, Kawasaki et al., 1998) Edg78E (Willis, 2007.1.3, Karouzou et al., 2007, Zhou and Riddiford, 2008, Blanco et al., 2010, Karouzou et al., 2007, Blanco et al., 2008, Beckstead et al., 2005)
Name Synonym	Ecdysone-dependent gene 78E
Secondary FlyBase IDs
	FBpp0078062 FBtr0078408
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
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