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Gene Dmel\Ef1α48D

General Information
Symbol	Dmel\Ef1α48D	Species	D. melanogaster
Name	Elongation factor 1α48D	Annotation symbol	CG8280
Feature type	protein_coding_gene	FlyBase ID	FBgn0000556
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	ef-1α, Ef1alpha48D, EF1α, EF, F1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48C5-48C5	Sequence location	2R:7,779,597..7,783,025 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Elongation factor 1α48D is referred to in FlyBase by the symbol Dmel\Ef1α48D (CG8280, FBgn0000556). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation elongation factor activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan. 19 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein synthesis factor, GTP-binding; Translation elongation factor EF1A, eukaryotic/archaeal; Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal; Translation elongation factor EFTu/EF1A, C-terminal; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation/initiation factor/Ribosomal, beta-barrel. Summary of modENCODE Temporal Expression Profile: Extremely high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638351_s_at partially aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Ef1alpha48D: 13 out of 14 probes fall into this exonic region. Gene sequence location is 2R:7779597..7783025.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ef1α1: Elongation factor 1α #1 Encodes an α unit of the heterotrimeric protein, elongation factor 1, which promotes the binding of aminoacyl-tRNA to ribosomes. Originally isolated on the basis of its displaying 5 to 10 fold overexpression in females versus males. Ef1α1 is expressed throughout development. The rate of protein synthesis in Drosophila declines with age; this has been attributed to impaired binding of aminoacyl-tRNA to ribosomes, which is promoted by elongation- factor 1 (EF1); transcription of elongation factor-1 mRNA shown to decrease with age; by fifteen days following emergence the level of EF1 mRNA is but a few percent that of newly emerged adults (Webster and Webster, 1984, Mech. Ageing Dev. 24: 335-42). Transformation with Ef1α1 under the control of heat shock promoter increased the mean life span from 38.2 to 45.1 days at 25 and from 21.1 to 29.8 days at 29 (Shepherd et al.).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN29406 HFA07421
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48C5-48C5   Limits computationally determined from genome sequence between P{EP}walEP825&P{PZ}wal02516 and P{PZ}Ef1α48D01275
Experimentally Determined Cytological Location
Cytogenetic map Notes References 48C5-48C6   (determined by in situ hybridisation)   (Spradling et al., 1999) 48C1-48C2   48C5--6 48C6--8 48C7--8 48D1--2   (BDGP Project Members, 1994-1999) 48D-48D   (determined by in situ hybridisation)   (Walldorf et al., 1985)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ef1α48D for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ef1α48D-RA FBtr0088035  NM_058027   2059   463 Ef1α48D-RB FBtr0088036  NM_165850   2048   463
Additional Transcript Data & Comments
Reported size (kB)	2.0 (unknown) (Walldorf et al., 1985)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ef1α48D-PA   FBpp0087142   50.3   463   9.60     NP_477375   AAF58608 Ef1α48D-PB   FBpp0087143   50.3   463   9.60     NP_725085   AAM68698
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein synthesis factor, GTP-binding (IPR000795) Translation elongation factor EFTu/EF1A, C-terminal (IPR004160) Translation elongation factor EFTu/EF1A, domain 2 (IPR004161) Translation elongation factor EF1A, eukaryotic/archaeal (IPR004539) Translation elongation/initiation factor/Ribosomal, beta-barrel (IPR009000) Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (IPR009001)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201103   AA202350   AA202507   AA202835   AA203051   AA246542   AA246979   AA263227   AA263329   AA263373   AA264143   AA264351   AA264410   AA391883   AA392219   AA392407   AA438902   AA440195   AA440726   AA441685   AA541017   AA541111   AA567061   AA567554   AA567696   AA695096   AA695459   AA695460   AA696347   AA696772   AA697148   AA698157   AA698815   AA735137   AA735425   AA735582   AA735635   AA802001   AA802147   AA802534   AA803434   AA803468   AA803528   AA803836   AA803896   AA803902   AA816581   AA816685   AA817117   AA817482   AA817487   AA817489   AA817491   AA820165   AA820778   AA821060   AA940735   AA942177   AA949006   AA949076   AA949507   AA949587   AA949648   AA949667   AA950053   AA950418   AA950608   AA950631   AA950671   AA950712   AA950919   AA951056   AA951278   AA951332   AA951351   AA951394   AA951407   AA951478   AA951526   AA951530   AA951568   AA951575   AA951697   AA951716   AA951747   AA951818   AA951829   AA951857   AA952075   AA952253   AA978415   AA978461   AA978602   AA978643   AA978698   AA978878   AA978997   AA979000   AA979025   AA979093   AA979238   AA979241   AA979281   AA979322   AA979432   AA979475   AA979510   AA979514   AA990622   AA990813   AA990857   AA990872   AE013599 AAF58608   AE013599 AAM68698   AC005466   AF006642   AI061709   AI062529   AI062553   AI063151   AI063279   AI063423   AI063750   AI063768   AI064260   AI106592   AI106645   AI106752   AI106843   AI107105   AI107448   AI107908   AI107947   AI108241   AI108257   AI109130   AI109546   AI109603   AI113377   AI113421   AI114236   AI114375   AI124257   AI124325   AI134741   AI135412   AI135723   AI237952   AI238170   AI238218   AI238350   AI238499   AI238672   AI256873   AI256886   AI257051   AI257494   AI257708   AI258242   AI258355   AI259446   AI259496   AI259534   AI259539   AI259914   AI259985   AI260135   AI260471   AI260600   AI260700   AI260865   AI260900   AI260983   AI260984   AI292852   AI293383   AI293403   AI293412   AI293458   AI293595   AI293699   AI294183   AI294205   AI294272   AI294356   AI294409   AI294455   AI294473   AI294503   AI295138   AI295506   AI295797   AI296216   AI296497   AI297806   AI297976   AI387114   AI388516   AI388562   AI389861   AI403316   AI403494   AI403571   AI403628   AI404385   AI404389   AI404406   AI405693   AI405911   AI405914   AI406076   AI455581   AI456157   AI456172   AI456560   AI456722   AI456893   AI511665   AI511891   AI512904   AI513042   AI513055   AI513530   AI514347   AI514748   AI514963   AI515333   AI515414   AI515541   AI515665   AI515813   AI516413   AI516458   AI516587   AI516659   AI516706   AI516911   AI516964   AI517376   AI517896   AI518160   AI518276   AI518401   AI519521   AI519913   AI519958   AI520214   AI520528   AI530775   AI530856   AI531130   AI531149   AI531869   AI532119   AI532222   AI532332   AI532455   AI532547   AI532632   AI532824   AI533010   AI533011   AI533117   AI533246   AI533258   AI533262   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BP550299   BP551060   BP551712   BP552397   BP552398   BP552448   BP552449   BP553189   BP553190   BP553640   BP553999   BP554348   BP554349   BP554626   BP554627   BP554819   BP555352   BP555624   BP556237   BP556555   BP556589   BP557095   BP557947   BP558478   BP558558   BP559016   BP559326   BP559910   BP560029   BP560030   BQ102886   BQ102989   BQ103553   BT001873 AAN71645   BT011039   BT015202   BT025890   BT099573   BX025466   BX030848   BX049009   BX054558   CA804646   CA804858   CA805058   CA805162   CA805537   CA805581   CA806576   CA806755   CA806773   CA806834   CA806945   CA807014   CA807365   CA807772   CA807823   CK131692   CK131787   CK131943   CK445252   CK604817   CK604818   CK657345   CK657459   CK657964   CK658263   CK659335   CK659436   CK659783   CK662015   CK662370   CL632194   CO154228   CO154276   CO155624   CO177770   CO178121   CO179798   CO180147   CO180677   CO181915   CO183510   CO184148   CO184868   CO185002   CO185723   CO186210   CO186294   CO188480   CO189105   CO189366   CO190378   CO191312   CO192179   CO192875   CO193107   CO193720   CO194668   CO194674   CO194828   CO194982   CO195040   CO195867   CO263872   CO264025   CO264462   CO264780   CO268074   CO268562   CO270138   CO270139   CO271546   CO272137   CO274941   CO277595   CO278174   CO278522   CO278544   CO279560   CO279959   CO281107   CO282386   CO282701   CO285315   CO285370   CO285508   CO286243   CO287222   CO287532   CO288066   CO288573   CO289393   CO289517   CO291207   CO292055   CO293105   CO294319   CO294727   CO295583   CO295657   CO296183   CO298898   CO301262   CO306109   CO310820   CO311679   CO312902   CO316323   CO317406   CO317700   CO319069   CO323023   CO323151   CO325685   CO325773   CO326669   CO329231   CO331884   CO332079   CO332823   CO338165   CO344675   CR937953   CR938008   CR938282   CR938356   CZ476253   DQ440206   DQ675557   EC053087   EC054757   EC058563   EC060947   EC061073   EC061139   EC061770   EC062211   EC062253   EC064029   EC065442   EC065912   EC067735   EC068548   EC069271   EC069613   EC070110   EC071012   EC071461   EC071608   EC072249   EC074081   EC074619   EC074953   EC075933   EC078796   EC079164   EC079197   EC081086   EC081190   EC086623   EC087240   EC087958   EC089378   EC090081   EC090843   EC195414   EC195533   EC195746   EC199719   EC200771   EC203340   EC204230   EC207432   EC208971   EC209190   EC212903   EC213863   EC215471   EC217420   EC217451   EC217883   EC218913   EC219012   EC219405   EC221447   EC221567   EC222419   EC222781   EC223971   EC225306   EC227050   EC228021   EC228250   EC228902   EC231615   EC234068   EC234568   EC235135   EC235918   EC236966   EC238622   EC239010   EC241205   EC242171   EC242497   EC242498   EC244187   EC244225   EC244471   EC246956   EC248175   EC249166   EC249909   EC251853   EC261885   EC261892   EC262947   EC263169   EC266194   EL869961   EL869963   EL869965   EL870296   EL871571   EL871572   EL871688   EL871689   EL871811   EL871941   EL873113   EL873114   EL877668   EL877896   EL877917   EL878045   EL881142   EL882414   EL882528   EL883087   EL883088   EL883202   EL883322   ES688506   ES688545   ES688569   ES688659   ES688664   ES688668   ES688670   ES689257   ES689270   ES689288   ES689311   ES689318   ES689404   ES689413   ES689417   ES689419   ES689424   ES689437   ES689439   ES689464   ES689483   ES689487   ES689506   ES689507   ES689513   ES689515   ES689517   ES689552   ES690284   ES691049   ES691111   ES691113   ES691114   ES691116   ES691118   ES691119   ES691126   ES691128   ES691140   ES691141   ES691154   ES691158   ES691160   ES691162   ES691163   ES691164   ES691165   ES691168   ES691169   ES691176   ES691178   ES691179   ES691180   ES691181   ES691182   ES691185   ES691190   ES691193   ES691195   ES691198   ES691200   ES691204   ES691206   ES691212   ES691215   ES691223   ES691225   ES691230   ES691235   ES691239   ES691241   ES691247   ES691248   ES691254   ES691266   ES691268   ES691270   ES691272   ES691273   ES691279   ES691285   ES691286   ES691287   ES691289   ES691292   ES691296   ES691299   ES691302   ES691310   ES691311   ES691313   ES691317   ES691318   ES691323   ES691328   ES691331   ES691333   ES691340   ES691342   ES691344   ES691356   ES691357   ES691358   ES691366   ES691373   ES691374   ES691375   ES691377   ES691380   ES691382   ES691384   ES691385   ES691391   ES691395   ES691397   ES691398   ES691399   ES691402   ES691407   ES691408   ES691412   ES691415   ES691417   ES691531   ES691533   ES691535   ES691537   ES691538   ES691543   ES691546   ES691547   ES691548   ES691549   ES691552   ES691558   ES691559   ES691563   ES691564   ES691568   ES691569   ES691570   ES691572   ES691573   ES691575   ES691576   ES691578   ES691580   ES691581   ES691590   ES691594   ES691599   ES691601   ES691602   ES691606   ES691614   ES691619   ES691623   ES691628   ES691629   ES691632   ES691633   ES691634   ES691637   ES691641   ES691646   ES691650   ES691653   ES691654   ES691655   ES691656   ES691664   ES691667   ES691678   ES691680   ES691681   ES691685   ES691686   ES691703   ES691715   ES691717   ES691719   ES691720   ES691723   ES691724   ES691725   ES691728   ES691729   ES691730   ES691731   ES691732   ES691737   ES691739   ES691742   ES691744   ES691753   ES691755   ES691758   ES691768   ES691769   ES691773   ES691774   ES691775   ES691779   ES691781   ES691790   ES691791   ES691797   ES691803   ES691805   ES691809   ES691813   ES691814   ES691826   ES691827   ES691835   ES691837   ES691839   ES691840   ES691851   ES691853   ES691854   ES691859   ES691860   ES691861   ES691864   ES691865   ES691866   ES691868   ES691869   ES691871   ES691875   ES691877   ES691878   ES691880   ES691881   ES691883   ES691884   ES691886   ES691888   ES691889   ES691894   ES691895   ES691898   ES691903   ES691906   ES691908   ES691916   ES691920   ES691921   ES691922   ES691923   ES691925   ES691926   ES691927   ES691928   ES691930   ES691932   ES691933   ES691934   ES691935   ES691936   ES692252   ES692271   ES692512   ES692521   ES692599   ES692610   ES692679   ES693674   ES693737   ES693789   ES693879   ES694053   ES694114   ES694361   ES694366   ES694387   ES694463   ES694477   ES694493   ES694527   ES694529   ES694539   ES694569   ES694596   ES694621   ES694644   ES694651   ES694658   ES694792   ES694797   ES694798   ES694799   ES694805   ES694806   ES694819   ES694834   ES694835   ES694858   ES694871   ES694928   ES694929   ES694938   ES694960   ES694971   ES694985   ES694999   ES695002   ES695006   ES695019   ES695026   ES695061   ES695074   ES695079   ES695085   ES695105   ES695108   ES695119   ES695133   ES695139   ES695140   ES695146   ES695155   ES695158   ES695179   ES695187   ES695272   ES695314   ES695414   ES695429   ES695446   EV574797   EV574955   EV575236   EV575396   EV575441   EV575475   EV575752   EV576041   EV576324   EV576468   EV577046   EV577100   EV577181   EV578465   EV578667   EV578798   EV578913   EV578919   EV578994   EV579030   EV579253   EV579693   EV579807   EV580071   EV580427   EV580695   EV581180   EV581273   EV581324   EV581664   EV582030   EV582545   EV582629   EV582783   EV583229   EV583337   EV583632   EV583743   EV583920   EV584040   EV584072   EV584324   EV584572   EV584926   EV585008   EV585102   EV585112   EV585179   EV585239   EV585421   EV585722   EV586329   EV586383   EV586416   EV586499   EV586585   EV587136   EV587366   EV587646   EV587737   EV588242   EV588594   EV588609   EV588718   EV588731   EV588883   EV589503   EV589816   EV590099   EV590316   EV590674   EV591165   EV591167   EV591422   EV591448   EV591488   EV591622   EV591983   EV592094   EV592126   EV592571   EV592844   EV593244   EV593273   EV593314   EV593364   EV593627   EV593836   EV593884   EV594032   EV594133   EV594158   EV594183   EV594938   EV595143   EV595231   EV595655   EV595690   EV595825   EV595848   EV596215   EV596246   EV596418   EV596583   EV596815   EV596913   EV597010   EV597155   EV597346   EV597358   EV597368   EV597491   EV597648   EV597655   EV597805   EV597861   EV597929   EV598059   EV598073   EV598111   EV598131   EV598229   EV598389   EV598800   EV598904   EV599151   EV599227   EV599584   EV599630   EV599638   EV599700   EV599714   EV599723   EV599806   EV599849   EV600226   EV600446   EV600637   EV600799   G00459   GQ452009   M11744 AAA28526   X06869 CAA29993
UniProtKB/Swiss-Prot	P08736
UniProtKB/TrEMBL	Q8T3U3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 23024
Expression Data
Transcript Expression
dot blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Walldorf et al., 1985)
Additional Descriptive Data
	Ef1α48D transcript is expressed in all developmental stages. Expression in females is 5 to 10-fold higher than in males. (Walldorf et al., 1985)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000556    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000556 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Extremely high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000556 expression level Developmental Stage   Expression Level embryo 00-02hr    472432 embryo 02-04hr    685318 embryo 04-06hr    677128 embryo 06-08hr    638862 embryo 08-10hr    650241 embryo 10-12hr    545179 embryo 12-14hr    478588 embryo 14-16hr    503624 embryo 16-18hr    430160 embryo 18-20hr    379753 embryo 20-22hr    323697 embryo 22-24hr    318869 larva L1    592101 larva L2    575681 larva L3 12hr old    542131 larva L3 puffstage 1-2    472729 larva L3 puffstage 3-6    514407 larva L3 puffstage 7-9    539639 white prepupae new    458501 white prepupae 12hr    296974 white prepupae 24hr    295972 pupae 2d postWPP    197907 pupae 3d postWPP    144775 pupae 4d postWPP    184631 adult male 01day    207301 adult male 05day    235576 adult male 30day    250102 adult female 01day    565614 adult female 05day    538861 adult female 30day    554594 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (472432) embryo 02-04hr  (685318) embryo 04-06hr  (677128) embryo 06-08hr  (638862) embryo 08-10hr  (650241) embryo 10-12hr  (545179) embryo 12-14hr  (478588) embryo 14-16hr  (503624) embryo 16-18hr  (430160) embryo 18-20hr  (379753) embryo 20-22hr  (323697) embryo 22-24hr  (318869) larva L1  (592101) larva L2  (575681) larva L3 12hr old  (542131) larva L3 puffstage 1-2  (472729) larva L3 puffstage 3-6  (514407) larva L3 puffstage 7-9  (539639) white prepupae new  (458501) white prepupae 12hr  (296974) white prepupae 24hr  (295972) pupae 2d postWPP  (197907) pupae 3d postWPP  (144775) pupae 4d postWPP  (184631) adult male 01day  (207301) adult male 05day  (235576) adult male 30day  (250102) adult female 01day  (565614) adult female 05day  (538861) adult female 30day  (554594) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (472432) embryo 02-04hr  (685318) embryo 04-06hr  (677128) embryo 06-08hr  (638862) embryo 08-10hr  (650241) embryo 10-12hr  (545179) embryo 12-14hr  (478588) embryo 14-16hr  (503624) embryo 16-18hr  (430160) embryo 18-20hr  (379753) embryo 20-22hr  (323697) embryo 22-24hr  (318869) larva L1  (592101) larva L2  (575681) larva L3 12hr old  (542131) larva L3 puffstage 1-2  (472729) larva L3 puffstage 3-6  (514407) larva L3 puffstage 7-9  (539639) white prepupae new  (458501) white prepupae 12hr  (296974) white prepupae 24hr  (295972) pupae 2d postWPP  (197907) pupae 3d postWPP  (144775) pupae 4d postWPP  (184631) adult male 01day  (207301) adult male 05day  (235576) adult male 30day  (250102) adult female 01day  (565614) adult female 05day  (538861) adult female 30day  (554594) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (472432) embryo 02-04hr  (685318) embryo 04-06hr  (677128) embryo 06-08hr  (638862) embryo 08-10hr  (650241) embryo 10-12hr  (545179) embryo 12-14hr  (478588) embryo 14-16hr  (503624) embryo 16-18hr  (430160) embryo 18-20hr  (379753) embryo 20-22hr  (323697) embryo 22-24hr  (318869) larva L1  (592101) larva L2  (575681) larva L3 12hr old  (542131) larva L3 puffstage 1-2  (472729) larva L3 puffstage 3-6  (514407) larva L3 puffstage 7-9  (539639) white prepupae new  (458501) white prepupae 12hr  (296974) white prepupae 24hr  (295972) pupae 2d postWPP  (197907) pupae 3d postWPP  (144775) pupae 4d postWPP  (184631) adult male 01day  (207301) adult male 05day  (235576) adult male 30day  (250102) adult female 01day  (565614) adult female 05day  (538861) adult female 30day  (554594) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    472432 embryo 02-04hr    685318 embryo 04-06hr    677128 embryo 06-08hr    638862 embryo 08-10hr    650241 embryo 10-12hr    545179 embryo 12-14hr    478588 embryo 14-16hr    503624 embryo 16-18hr    430160 embryo 18-20hr    379753 embryo 20-22hr    323697 embryo 22-24hr    318869 larva L1    592101 larva L2    575681 larva L3 12hr old    542131 larva L3 puffstage 1-2    472729 larva L3 puffstage 3-6    514407 larva L3 puffstage 7-9    539639 white prepupae new    458501 white prepupae 12hr    296974 white prepupae 24hr    295972 pupae 2d postWPP    197907 pupae 3d postWPP    144775 pupae 4d postWPP    184631 adult male 01day    207301 adult male 05day    235576 adult male 30day    250102 adult female 01day    565614 adult female 05day    538861 adult female 30day    554594 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000556 expression level Developmental Stage   Expression Level embryo 00-02hr    472432 embryo 02-04hr    685318 embryo 04-06hr    677128 embryo 06-08hr    638862 embryo 08-10hr    650241 embryo 10-12hr    545179 embryo 12-14hr    478588 embryo 14-16hr    503624 embryo 16-18hr    430160 embryo 18-20hr    379753 embryo 20-22hr    323697 embryo 22-24hr    318869 larva L1    592101 larva L2    575681 larva L3 12hr old    542131 larva L3 puffstage 1-2    472729 larva L3 puffstage 3-6    514407 larva L3 puffstage 7-9    539639 white prepupae new    458501 white prepupae 12hr    296974 white prepupae 24hr    295972 pupae 2d postWPP    197907 pupae 3d postWPP    144775 pupae 4d postWPP    184631 adult male 01day    207301 adult male 05day    235576 adult male 30day    250102 adult female 01day    565614 adult female 05day    538861 adult female 30day    554594 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (472432) embryo 02-04hr  (685318) embryo 04-06hr  (677128) embryo 06-08hr  (638862) embryo 08-10hr  (650241) embryo 10-12hr  (545179) embryo 12-14hr  (478588) embryo 14-16hr  (503624) embryo 16-18hr  (430160) embryo 18-20hr  (379753) embryo 20-22hr  (323697) embryo 22-24hr  (318869) larva L1  (592101) larva L2  (575681) larva L3 12hr old  (542131) larva L3 puffstage 1-2  (472729) larva L3 puffstage 3-6  (514407) larva L3 puffstage 7-9  (539639) white prepupae new  (458501) white prepupae 12hr  (296974) white prepupae 24hr  (295972) pupae 2d postWPP  (197907) pupae 3d postWPP  (144775) pupae 4d postWPP  (184631) adult male 01day  (207301) adult male 05day  (235576) adult male 30day  (250102) adult female 01day  (565614) adult female 05day  (538861) adult female 30day  (554594) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (472432) embryo 02-04hr  (685318) embryo 04-06hr  (677128) embryo 06-08hr  (638862) embryo 08-10hr  (650241) embryo 10-12hr  (545179) embryo 12-14hr  (478588) embryo 14-16hr  (503624) embryo 16-18hr  (430160) embryo 18-20hr  (379753) embryo 20-22hr  (323697) embryo 22-24hr  (318869) larva L1  (592101) larva L2  (575681) larva L3 12hr old  (542131) larva L3 puffstage 1-2  (472729) larva L3 puffstage 3-6  (514407) larva L3 puffstage 7-9  (539639) white prepupae new  (458501) white prepupae 12hr  (296974) white prepupae 24hr  (295972) pupae 2d postWPP  (197907) pupae 3d postWPP  (144775) pupae 4d postWPP  (184631) adult male 01day  (207301) adult male 05day  (235576) adult male 30day  (250102) adult female 01day  (565614) adult female 05day  (538861) adult female 30day  (554594) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (472432) embryo 02-04hr  (685318) embryo 04-06hr  (677128) embryo 06-08hr  (638862) embryo 08-10hr  (650241) embryo 10-12hr  (545179) embryo 12-14hr  (478588) embryo 14-16hr  (503624) embryo 16-18hr  (430160) embryo 18-20hr  (379753) embryo 20-22hr  (323697) embryo 22-24hr  (318869) larva L1  (592101) larva L2  (575681) larva L3 12hr old  (542131) larva L3 puffstage 1-2  (472729) larva L3 puffstage 3-6  (514407) larva L3 puffstage 7-9  (539639) white prepupae new  (458501) white prepupae 12hr  (296974) white prepupae 24hr  (295972) pupae 2d postWPP  (197907) pupae 3d postWPP  (144775) pupae 4d postWPP  (184631) adult male 01day  (207301) adult male 05day  (235576) adult male 30day  (250102) adult female 01day  (565614) adult female 05day  (538861) adult female 30day  (554594) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    472432 embryo 02-04hr    685318 embryo 04-06hr    677128 embryo 06-08hr    638862 embryo 08-10hr    650241 embryo 10-12hr    545179 embryo 12-14hr    478588 embryo 14-16hr    503624 embryo 16-18hr    430160 embryo 18-20hr    379753 embryo 20-22hr    323697 embryo 22-24hr    318869 larva L1    592101 larva L2    575681 larva L3 12hr old    542131 larva L3 puffstage 1-2    472729 larva L3 puffstage 3-6    514407 larva L3 puffstage 7-9    539639 white prepupae new    458501 white prepupae 12hr    296974 white prepupae 24hr    295972 pupae 2d postWPP    197907 pupae 3d postWPP    144775 pupae 4d postWPP    184631 adult male 01day    207301 adult male 05day    235576 adult male 30day    250102 adult female 01day    565614 adult female 05day    538861 adult female 30day    554594 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000556    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000556 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000556 expression level Tissue   Expression Level Larval Central Nervous System    3329.75 Larval Midgut    7121.1 Larval Hindgut    5866.6 Larval Malpighian Tubules    6335 Larval Fat Body    9427.7 Larval Salivary Gland    9565.5 Larval Trachea    6999.675 Larval Carcass    5806.2 Adult Head    5267.7 Adult Eye    6993.975 Adult Brain    2777.3 Adult Thoracic-Abdominal Ganglion    3858.8 Adult Crop    6565 Adult Midgut    5939.5 Adult Hindgut    5524.3 Adult Malpighian Tubules    7586.7 Adult Fat Body    7308.2 Adult Salivary Gland    17625.9 Adult Heart    8431.475 Adult VirginFemale Spermatheca    7227.5 Adult InseminatedFemale Spermatheca    7262.6 Adult Ovary    3972.6 Adult Testis    2540.4 Adult Male Accessory Gland    10982.4 Adult Carcass    7456.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3329.75) Larval Midgut  (7121.1) Larval Hindgut  (5866.6) Larval Malpighian Tubules  (6335) Larval Fat Body  (9427.7) Larval Salivary Gland  (9565.5) Larval Trachea  (6999.675) Larval Carcass  (5806.2) Adult Head  (5267.7) Adult Eye  (6993.975) Adult Brain  (2777.3) Adult Thoracic-Abdominal Ganglion  (3858.8) Adult Crop  (6565) Adult Midgut  (5939.5) Adult Hindgut  (5524.3) Adult Malpighian Tubules  (7586.7) Adult Fat Body  (7308.2) Adult Salivary Gland  (17625.9) Adult Heart  (8431.475) Adult VirginFemale Spermatheca  (7227.5) Adult InseminatedFemale Spermatheca  (7262.6) Adult Ovary  (3972.6) Adult Testis  (2540.4) Adult Male Accessory Gland  (10982.4) Adult Carcass  (7456.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3329.75) Larval Midgut  (7121.1) Larval Hindgut  (5866.6) Larval Malpighian Tubules  (6335) Larval Fat Body  (9427.7) Larval Salivary Gland  (9565.5) Larval Trachea  (6999.675) Larval Carcass  (5806.2) Adult Head  (5267.7) Adult Eye  (6993.975) Adult Brain  (2777.3) Adult Thoracic-Abdominal Ganglion  (3858.8) Adult Crop  (6565) Adult Midgut  (5939.5) Adult Hindgut  (5524.3) Adult Malpighian Tubules  (7586.7) Adult Fat Body  (7308.2) Adult Salivary Gland  (17625.9) Adult Heart  (8431.475) Adult VirginFemale Spermatheca  (7227.5) Adult InseminatedFemale Spermatheca  (7262.6) Adult Ovary  (3972.6) Adult Testis  (2540.4) Adult Male Accessory Gland  (10982.4) Adult Carcass  (7456.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3329.75 Larval Midgut    7121.1 Larval Hindgut    5866.6 Larval Malpighian Tubules    6335 Larval Fat Body    9427.7 Larval Salivary Gland    9565.5 Larval Trachea    6999.675 Larval Carcass    5806.2 Adult Head    5267.7 Adult Eye    6993.975 Adult Brain    2777.3 Adult Thoracic-Abdominal Ganglion    3858.8 Adult Crop    6565 Adult Midgut    5939.5 Adult Hindgut    5524.3 Adult Malpighian Tubules    7586.7 Adult Fat Body    7308.2 Adult Salivary Gland    17625.9 Adult Heart    8431.475 Adult VirginFemale Spermatheca    7227.5 Adult InseminatedFemale Spermatheca    7262.6 Adult Ovary    3972.6 Adult Testis    2540.4 Adult Male Accessory Gland    10982.4 Adult Carcass    7456.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000556 expression level Tissue   Expression Level Larval Central Nervous System    3329.75 Larval Midgut    7121.1 Larval Hindgut    5866.6 Larval Malpighian Tubules    6335 Larval Fat Body    9427.7 Larval Salivary Gland    9565.5 Larval Trachea    6999.675 Larval Carcass    5806.2 Adult Head    5267.7 Adult Eye    6993.975 Adult Brain    2777.3 Adult Thoracic-Abdominal Ganglion    3858.8 Adult Crop    6565 Adult Midgut    5939.5 Adult Hindgut    5524.3 Adult Malpighian Tubules    7586.7 Adult Fat Body    7308.2 Adult Salivary Gland    17625.9 Adult Heart    8431.475 Adult VirginFemale Spermatheca    7227.5 Adult InseminatedFemale Spermatheca    7262.6 Adult Ovary    3972.6 Adult Testis    2540.4 Adult Male Accessory Gland    10982.4 Adult Carcass    7456.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3329.75) Larval Midgut  (7121.1) Larval Hindgut  (5866.6) Larval Malpighian Tubules  (6335) Larval Fat Body  (9427.7) Larval Salivary Gland  (9565.5) Larval Trachea  (6999.675) Larval Carcass  (5806.2) Adult Head  (5267.7) Adult Eye  (6993.975) Adult Brain  (2777.3) Adult Thoracic-Abdominal Ganglion  (3858.8) Adult Crop  (6565) Adult Midgut  (5939.5) Adult Hindgut  (5524.3) Adult Malpighian Tubules  (7586.7) Adult Fat Body  (7308.2) Adult Salivary Gland  (17625.9) Adult Heart  (8431.475) Adult VirginFemale Spermatheca  (7227.5) Adult InseminatedFemale Spermatheca  (7262.6) Adult Ovary  (3972.6) Adult Testis  (2540.4) Adult Male Accessory Gland  (10982.4) Adult Carcass  (7456.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3329.75) Larval Midgut  (7121.1) Larval Hindgut  (5866.6) Larval Malpighian Tubules  (6335) Larval Fat Body  (9427.7) Larval Salivary Gland  (9565.5) Larval Trachea  (6999.675) Larval Carcass  (5806.2) Adult Head  (5267.7) Adult Eye  (6993.975) Adult Brain  (2777.3) Adult Thoracic-Abdominal Ganglion  (3858.8) Adult Crop  (6565) Adult Midgut  (5939.5) Adult Hindgut  (5524.3) Adult Malpighian Tubules  (7586.7) Adult Fat Body  (7308.2) Adult Salivary Gland  (17625.9) Adult Heart  (8431.475) Adult VirginFemale Spermatheca  (7227.5) Adult InseminatedFemale Spermatheca  (7262.6) Adult Ovary  (3972.6) Adult Testis  (2540.4) Adult Male Accessory Gland  (10982.4) Adult Carcass  (7456.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3329.75 Larval Midgut    7121.1 Larval Hindgut    5866.6 Larval Malpighian Tubules    6335 Larval Fat Body    9427.7 Larval Salivary Gland    9565.5 Larval Trachea    6999.675 Larval Carcass    5806.2 Adult Head    5267.7 Adult Eye    6993.975 Adult Brain    2777.3 Adult Thoracic-Abdominal Ganglion    3858.8 Adult Crop    6565 Adult Midgut    5939.5 Adult Hindgut    5524.3 Adult Malpighian Tubules    7586.7 Adult Fat Body    7308.2 Adult Salivary Gland    17625.9 Adult Heart    8431.475 Adult VirginFemale Spermatheca    7227.5 Adult InseminatedFemale Spermatheca    7262.6 Adult Ovary    3972.6 Adult Testis    2540.4 Adult Male Accessory Gland    10982.4 Adult Carcass    7456.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5267.7   NA  Eye    6993.975   NA  Brain    2777.3   3329.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3858.8   NA  Crop    6565   7121.1  Midgut    5939.5   5866.6  Hindgut    5524.3   6335  Malpighian Tubules    7586.7   9427.7  Fat Body    7308.2   9565.5  Salivary Gland    17625.9   NA  Heart    8431.475   6999.675  Trachea    NA   NA  VirginFemale Spermatheca    7227.5   NA  InseminatedFemale Spermatheca    7262.6   NA  Ovary    3972.6   NA  Testis    2540.4   NA  Male Accessory Gland    10982.4   5806.2  Carcass    7456.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000556 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8280-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU Ef1α48DGD13875 Ef1α48DGD17848 lethal, with Scer\GAL4Bx-MS1096 Ef1α48DGD13875 Ef1α48DGD17848 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH Ef1α48DGD13875 Ef1α48DGD17848 lethal, with Scer\GAL4pnr-MD237 Ef1α48DGD13875 Ef1α48DGD17848 lethal | pupal stage, with Scer\GAL4pnr-MD237 Ef1α48DGD13875 Ef1α48DGD17848 lethal | recessive Ef1α48D01275 Ef1α48D04829 Ef1α48Dk06102 Ef1α48Dk07303 Ef1α48Dk07507 Ef1α48Dk10501 Ef1α48Dk17014 Phenotype manifest in Allele
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of Ef1α48D Class Mutagen Stocks Known lesion Ef1α48DEY09615 P-element activity 2 -- Ef1α48Dk06102 P-element activity 2 -- Ef1α48D01275 P-element activity 1 Yes Ef1α48DCB-5508-3 1 -- Ef1α48DCB-6286-3 1 -- Ef1α48Dd10427 1 -- Ef1α48DG13120 P-element activity 1 -- Ef1α48Dk07303 P-element activity 1 -- Ef1α48Dk07507 P-element activity 1 -- Ef1α48Dk10501 P-element activity 1 -- Ef1α48D04829 P-element activity 0 -- Ef1α48DBSC25 0 Yes Ef1α48Dd08476 P-element activity 0 -- Ef1α48Dk17014 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ef1α48D Class Mutagen Stocks Known lesion Ef1α48DGD13875 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ef1α48DGD17848 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ef1α48DHMS00917 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ef1α48DKK109406 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ef1α48Dhs.PS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(2R)BSC25 (Stathopoulos et al., 2004)
Not disrupted in	Df(2R)en30 (BDGP Project Members, 1994-1999) Df(2R)vg135 (BDGP Project Members, 1994-1999) In(2R)vgW (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hsp70-EF-1α} NA reporter construct P{EFPlacZ} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Ef1α48Dk06102 No P{lacW}Ef1α48Dk07303 No P{lacW}Ef1α48Dk07507 No P{lacW}Ef1α48Dk10501 No P{lacW}Ef1α48Dk17014 No P{lacW}l(2)SH0396SH0396 No P{PZ}Ef1α48D01275 No P{PZ}Ef1α48D04829 No P{PZ}l(2)0024800248 No insertion of mobile activating element P{EP}Ef1α48DG13120 NA P{EPgy2}Ef1α48DEY09615 NA P{XP}Ef1α48Dd08476 NA P{XP}Ef1α48Dd10427 NA miscellaneous insertions P{RS3}Ef1α48DCB-5508-3 NA P{RS3}Ef1α48DCB-6286-3 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Shepherd et al., 1989)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR000795 (FlyBase Curators et al., 2004-) non-traceable author statement (Mi et al., 2001.12.13) GTP binding inferred from electronic annotation with InterPro:IPR000795, InterPro:IPR004160, InterPro:IPR004161, InterPro:IPR004539 (FlyBase Curators et al., 2004-) translation elongation factor activity inferred from sequence or structural similarity (Spradling et al., 1999, Lasko, 2000) inferred from sequence or structural similarity with EMBL:AF015267 (Mi et al., 2001.12.13) non-traceable author statement (Swiss-Prot Project Members, 1988.8.1)
Biological Process
CV term Evidence References
translation non-traceable author statement (Mi et al., 2001.12.13) translational elongation inferred from electronic annotation with InterPro:IPR004539 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Spradling et al., 1999, Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1988.8.1)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1988.8.1) cytosol inferred from sequence or structural similarity (Spradling et al., 1999) eukaryotic translation elongation factor 1 complex inferred from sequence or structural similarity (Spradling et al., 1999, Lasko, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ef1α48D allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62056 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000556 DroID - A comprehensive database of gene and protein interactions. • FBgn0000556 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36271
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13105 Dere\GG20229 Dgri\GH21478 Dmoj\GI19955 Dpse\GA20951 Dsim\GD10821 Dvir\GJ17887 Dwil\GK22048 Dyak\GE12389
Curated drosophilid orthologs	Dpse\GA20951
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP007406-PA Anopheles gambiae (mosquito) At1g07920.1 Arabidopsis thaliana (wall cress) At1g07930.1 Arabidopsis thaliana (wall cress) At1g07940.1 Arabidopsis thaliana (wall cress) At5g60390.1 Arabidopsis thaliana (wall cress) 19314 Batrachochytrium dendrobatidis (chytrid fungus) 122567 Branchiostoma floridae (lancelet) 126207 Branchiostoma floridae (lancelet) 58879 Branchiostoma floridae (lancelet) 91258 Branchiostoma floridae (lancelet) XP_001896880.1 Brugia malayi (roundworm nematode) BGIBMGA003608-PA Bombyx mori (silk worm) ENSBTAP00000019318 Bos taurus (bovine) CAL0004558 Candida albicans (a form of yeast) CAL0004916 Candida albicans (a form of yeast) CN06528 Caenorhabditis brenneri (small nematode) CN09621 Caenorhabditis brenneri (small nematode) CBP04009 Caenorhabditis briggsae (nematode) CE01270 Caenorhabditis elegans (worm) ENSCAFP00000003867 Canis familiaris (dog) ENSCAFP00000027428 Canis familiaris (dog) CAGL0D01188g Candida glabrata (haploid yeast) CAGL0K07832g Candida glabrata (haploid yeast) JA02926 Caenorhabditis japonica (nematode) cn13119 Cryptococcus neoformans (yeast-like fungus) CPIJ009303 Culex pipens (mosquito) ENSCPOP00000003669 Cavia porcellus (guinea pig) 132905 Chlamidomonas reinhardtii (green alga) 134382 Chlamidomonas reinhardtii (green alga) RP42119 Caenorhabditis remanei (nematode) RP44027 Caenorhabditis remanei (nematode) ENSCSAVP00000010846 Ciona savignyi (sedentary tunicate) DEHA2D02376g Debaryomyces Hansenii (yeast) DEHA2F03828g Debaryomyces Hansenii (yeast) 300308 Daphnia pulex (daphnia) ENSDARP00000006339 Danio rerio (zebra fish) ENSECAP00000003695 Equus caballus (horse) ENSECAP00000018148 Equus caballus (horse) XP_648361 Entamoeba histolytica (anaerobic protozoan) XP_648717 Entamoeba histolytica (anaerobic protozoan) XP_651869 Entamoeba histolytica (anaerobic protozoan) ENSGALP00000025606 Gallus gallus (chicken) ENSP00000339063 Homo sapiens (human) KLLA0B08998g Kluyveromyces lactis (yeast) 239271 Lottia gigantea (owl limpet) LmjF17.0080 Leishmania major (virus) LmjF17.0081 Leishmania major (virus) LmjF17.0082 Leishmania major (virus) LmjF17.0083 Leishmania major (virus) LmjF17.0084 Leishmania major (virus) LmjF17.0085 Leishmania major (virus) LmjF17.0086 Leishmania major (virus) ENSMODP00000023121 Monodelphis domestica (gray opossum) ENSMMUP00000006451 Macaca mulatta (rhesus monkey) ENSMUSP00000042457 Mus musculus (house mouse) 247215 Nematostella vectensis (starlet anemone) ENSOANP00000007773 Ornithorynchus anatinus (platypus) ENSORLP00000009506 Oryzias latipes (japanese killifish) ENSORLP00000009543 Oryzias latipes (japanese killifish) LOC_Os03g08010.1 Oryza sativa (asian rice) LOC_Os03g08020.1 Oryza sativa (asian rice) LOC_Os03g08050.1 Oryza sativa (asian rice) LOC_Os03g08060.1 Oryza sativa (asian rice) PP18988 Pristionchus pacificus (nematode) 104509 Physcomitrella patens (moss) 158894 Physcomitrella patens (moss) 158916 Physcomitrella patens (moss) 163704 Physcomitrella patens (moss) 182696 Physcomitrella patens (moss) 210098 Physcomitrella patens (moss) 212963 Physcomitrella patens (moss) 76520 Physcomitrella patens (moss) ENSPPYP00000018778 Pongo pygmaeus (orangutan) ENSPPYP00000018935 Pongo pygmaeus (orangutan) 655943 Populus trichocarpa (black cottonwood) 655949 Populus trichocarpa (black cottonwood) 720367 Populus trichocarpa (black cottonwood) ENSPTRP00000045593 Pan troglodytes (chimpanzee) ENSRNOP00000013608 Rattus norvegicus (norway rat) ENSRNOP00000017180 Rattus norvegicus (norway rat) 146828 Sorghum bicolor (sorghum) 150010 Sorghum bicolor (sorghum) 4865263 Sorghum bicolor (sorghum) 4994745 Sorghum bicolor (sorghum) YBR118W Saccharomyces cerevisiae (budding yeast) YPR080W Saccharomyces cerevisiae (budding yeast) SPAC23A1.10 Schizosaccharomyces pombe (fission yeast) SPBC839.15c Schizosaccharomyces pombe (fission yeast) SPCC794.09c Schizosaccharomyces pombe (fission yeast) XP_001176381.1 Strongylocentrotus purpuratus (purple sea urchin) 36635 Trichoplax adhaerens (metazoa) NP_001107835.1 Tribolium castaneum (red flour beetle) Tc00.1047053510119.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511367.360 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511367.370 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511369.20 Trypanosoma cruzi (parasitic trypanosome) 96.m00145 Tetrahymena thermophila (ciliate protozoa) 82490.m00257 Trichomonas vaginalis (parasitic flagellated protozoan) 96267.m00166 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002561 Xenopus tropicalis (frog) YALI0C09141g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230135 FBgn0224033 FBgn0205055 FBgn0182584 FBgn0080940 FBgn0142692 FBgn0128940 FBgn0112420 FBgn0090138 CPIJ009303 BGIBMGA003608 AGAP007406 GLEAN_01880
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	28393 y1 w*; P{EP}Ef1α48DG13120 11034 cn1 P{PZ}Ef1α48D01275/CyO; ry506 33960 y1 sc* v1; P{TRiP.HMS00917}attP2 10397 y1 w67c23; P{lacW}Ef1α48Dk06102/CyO 19959 y1 w67c23; P{EPgy2}Ef1α48DEY09615/CyO
Harvard	- P{XP}Ef1α48Dd10427
Kyoto	123667 w1118; P{RS3}Ef1α48DCB-5508-3 124024 w1118; P{RS3}Ef1α48DCB-6286-3
VDRC	v104502 P{KK109406}VIE-260B v24270 w1118; P{GD13875}v24270 v24271 w1118; P{GD13875}v24271 v49890 w1118; P{GD17848}v49890/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR14L19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2010 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM14559 IP02096 LP10071 RE68984 SD08285
Other clones	DPiM_RE68984 RH01053
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01782 GH03724 GH05138 GH05847 GH06080 GH06408 GH07028 GH07047 GH07687 GH08771 GH09085 GH11017 GH11205 GH13145 GH14171 GH14229 GH14378 GH19457 GH22729 GH22946 GH24063 GH24096 GH26064 GH26067 GH26262 GH26655 GM02862 GM13167 GM14395 GM15411 GM21112 GM30010 GM30143 HL03858 LD03159 LD03293 LD06520 LD07547 LD07715 LD20920 LD21284 LD22237 LD22980 LD22992 LD22994 LD24659 LD26246 LD27737 LD27832 LD30469 LD30508 LD30608 LD31088 LD31332 LD31663 LD31743 LD32054 LD32171 LD32405 LD32542 LD32591 LD33230 LD33233 LD33587 LD33718 LD33790 LD33821 LD33992 LD34071 LD34129 LD34791 LD36036 LD36621 LD36838 LD37058 LD37592 LD37745 LD39758 LD39835 LD40181 LD40716 LD42272 LD42333 LD42686 LD43144 LD45258 LD47221 LD47235 LD47801 LD47983 LP03544 LP04348 LP04855 LP04894 LP04988 LP05041 LP05881 LP06520 LP06611 LP06767 LP07605 LP07713 LP07853 LP07891 LP08682 LP09537 LP10425 LP12670 LP12791 LP13052 LP14261 LP21919 LP23556 LP23776 RE30215 RH46681 SD01016 SD01047 SD01521 SD01601 SD02030 SD02069 SD03152 SD03491 SD03634 SD03978 SD04450 SD05003 SD05016 SD05629 SD05671 SD05762 SD05781 SD05991 SD06447 SD06657 SD06993 SD08028 SD08102 SD08182 SD08386 SD08591 SD08950 SD09022 SD09025 SD09059 SD09218 SD09586 SD09588 SD09590 SD09846 SD09903 SD10055 SD10106 SD10356 SD10681 SD10750 SD10804 SD11288 SD11996 SD12051 SD12057 SD12063 SD12218 SD12692 SD12793 SD12802 SD13003 SD13129 SD13159 SD13162 SD13641 SD13793 SD13887 SD13919 SD14070 SD14208 SD14236 SD14333 SD14482 SD14541 SD14757 SD14843 SD14971 SD15048 SD15270 SD15601 SD15910 SD15914 SD15973 SD16049 SD16288 SD17532 SD18378 SD20735 SD20909 SD21137 SD21830 SD22292 SD22435 SD22764 SD22867 SD23016 SD23079 SD23086 SD23256 SD23465 SD23675 SD23749 SD23890 SD26313 SD26376 SD27444 SD27711 SD27928 SD28295
Other clones	7725 16500 16934 17688 17718 18751 21362 28695 29377 30784 39090 43947 45246 47473 47541 50372 52689 56452 56543 63805 64316 65191 70086 70087 71032 72607 76517 77199 78358 81618 96990 102258 102473 104264 105229 105436 117622 144533 144571 145439 160822 162948 163402 163982 164435 165295 175114 180858 190103 194820 214309.23 273712 274142 274317 277715 283533 523277 523389 525061 542665 570021 AT21564 AT28548 CK01.10A.C7 CK01.17B.H6 CK01.18C.E2 CK01.19C.C11 CK01.32C.E4 CK01.50C.A10 CK01.53B.H3 CK01.54A.G2 CK01.59A.E10 CK01.64D.C2 CK01.67B.C12 CK01.69A.F12 CK01.73D.E5 CK01.80B.F1 CK01.82D.F3 CK01.83A.C7 CK01.85B.E12 CK01.87B.C9 CK01.90B.H1 CK01.91A.F11 CK01.99B.H7 CK01.120C.E6 CK01.142D.C3 CK01.167C.B4 CK01.169B.A8 Dmel_dig_001815_0654_0549 Dmel_dig_001849_0650_1830 Dmel_dig_002030_0661_0325 Dmel_dig_002482_0704_0473 Dmel_dig_002759_0654_3626 Dmel_dig_002899_0657_3779 Dmel_dig_004306_0641_1062 Dmel_dig_004798_0620_1745 Dmel_dig_005370_0586_2662 Dmel_dig_005388_0712_0676 Dmel_dig_006131_0606_1339 Dmel_dig_006189_0625_0569 Dmel_dig_007833_0701_0473 Dmel_dig_007959_0634_3247 Dmel_dig_008003_0656_1804 Dmel_dig_008048_0620_3755 Dmel_dig_008692_0671_1465 Dmel_dig_009104_0631_0666 Dmel_dig_009369_0612_2917 Dmel_dig_009745_0676_1905 Dmel_dig_010146_0685_1567 Dmel_dig_010535_0709_2539 Dmel_dig_010688_0677_2866 Dmel_dig_010834_0682_0723 Dmel_dig_011410_0603_2042 Dmel_dig_012251_0629_3450 Dmel_dig_012478_0666_1063 Dmel_dig_012698_0704_3440 Dmel_dig_012789_0673_0974 Dmel_dig_012976_0588_1401 Dmel_dig_013705_0692_1064 Dmel_dig_013782_0615_3245 Dmel_dig_013805_0693_0834 Dmel_dig_014025_0683_2102 Dmel_dig_014128_0636_2767 Dmel_dig_014849_0712_2540 Dmel_dig_014964_0664_1833 Dmel_dig_015155_0589_1116 Dmel_dig_015723_0599_0977 Dmel_dig_016715_0687_0998 Dmel_dig_017004_0644_3247 Dmel_dig_017072_0690_1036 Dmel_dig_017603_0594_2066 Dmel_dig_017971_0702_3449 Dmel_dig_018661_0618_0698 Dmel_dig_018699_0620_3341 Dmel_dig_018845_0605_2983 Dmel_dig_019050_0582_3490 Dmel_dig_019125_0592_1176 Dmel_dig_019291_0652_3435 Dmel_dig_019981_0594_3270 Dmel_neb_000484_0081_3657 Dmel_neb_003027_0941_2930 Dmel_neb_006526_0141_0678 Dmel_neb_007122_0665_3573 Dmel_neb_007958_0823_2996 Dmel_neb_008151_0620_0643 Dmel_neb_008272_0624_1546 Dmel_neb_008317_0603_2973 Dmel_neb_008670_0568_2408 Dmel_neb_009463_0695_0755 Dmel_neb_009869_0937_0541 Dmel_neb_009992_0940_3159 Dmel_neb_010085_0599_1932 Dmel_neb_010118_0911_0471 Dmel_neb_010124_0936_3352 Dmel_neb_010632_0836_1975 Dmel_neb_010643_0671_3572 Dmel_neb_010721_0873_3318 Dmel_neb_010826_0320_3559 Dmel_neb_010876_0582_1373 Dmel_neb_010942_0606_3368 Dmel_neb_011129_0403_1608 Dmel_neb_011178_0670_3138 Dmel_neb_011445_0318_2185 Dmel_neb_011449_0577_3478 Dmel_neb_011450_0140_1667 Dmel_neb_011557_0821_1411 Dmel_neb_011608_0352_2004 Dmel_neb_011727_0822_1417 Dmel_neb_011771_0076_1752 Dmel_neb_011789_0685_2254 Dmel_neb_011790_0855_1505 Dmel_neb_011945_0177_2741 Dmel_neb_012193_0406_1639 Dmel_neb_012343_0679_2955 Dmel_neb_012408_0181_1723 Dmel_neb_012417_0706_0371 Dmel_neb_012436_0916_1726 Dmel_neb_012470_0944_1973 Dmel_neb_012508_0609_0734 Dmel_neb_012546_0938_2836 Dmel_neb_012594_0826_1204 Dmel_neb_012689_0607_2696 Dmel_neb_012709_0129_2976 Dmel_neb_012804_0891_2005 Dmel_neb_012953_0913_2787 Dmel_neb_013020_0614_1576 Dmel_neb_013051_0674_3457 Dmel_neb_013229_0900_2410 Dmel_neb_013254_0910_0784 Dmel_neb_013298_0934_3116 Dmel_neb_013324_0936_3205 Dmel_neb_013344_0444_0572 Dmel_neb_013361_0168_2373 Dmel_neb_013434_0353_2297 Dmel_neb_013453_0925_1854 Dmel_neb_013537_0942_0758 Dmel_neb_013571_0863_0832 Dmel_neb_013636_0915_3432 Dmel_neb_013700_0569_2179 Dmel_neb_013720_0866_2081 Dmel_neb_013763_0937_3178 Dmel_neb_013844_0414_3350 Dmel_neb_013884_0143_2984 Dmel_neb_013974_0091_1265 Dmel_neb_014281_0315_2073 Dmel_neb_014345_0680_3196 Dmel_neb_014382_0198_0596 Dmel_neb_014542_0643_1356 Dmel_neb_014555_0139_3137 Dmel_neb_014602_0943_3367 Dmel_neb_014656_0901_1768 Dmel_neb_014680_0380_0730 Dmel_neb_014723_0119_3083 Dmel_neb_014730_0832_2277 Dmel_neb_014757_0877_2793 Dmel_neb_014824_0113_3443 Dmel_neb_014881_0942_2833 Dmel_neb_014989_0848_2132 Dmel_neb_015056_0178_2453 Dmel_neb_015271_0604_2772 Dmel_neb_015276_0880_2842 Dmel_neb_015571_0936_1779 Dmel_neb_015735_0390_1368 Dmel_neb_015789_0575_1699 Dmel_neb_015904_0631_2758 Dmel_neb_016161_0826_2087 Dmel_neb_016535_0825_2084 EC00225 EC01043 EC03153 EC16001 EC25866 EC27232 EC28711 EC29092 EC30680 EC33304 EC34687 EC35136 EC36680 EC39001 EC39013 EC39284 EC39548 EC39619 EC42401 EC053087 EC054757 EK011203 EK016863 EK018510 EK040435 EK043030 EK044057 EK047938 EK054242 EK055354 EK062221 EK065241 EK066122 EK067650 EK068911 EK070929 EK071224 EK076532 EK090105 EK091939 EK097609 EK097641 EK103836 EK106004 EK116010 EK125564 EK129162 EK130262 EK130334 EK135302 EK136730 EK137219 EK139306 EK140319 EK152054 EK156002 EK160340 EK161013 EK168738 EK168842 EK169136 EK174053 EK180608 EK189521 EK189834 EK197160 EK197428 EK199101 EK201723 EK206548 EK207540 EK210752 EK211303 EK213006 EK222707 EK225836 EK230526 EK250259 EK264524 EK267932 EK268826 EK276142 EK292318 EK301922 EK302448 EK304744 EN03745 EN03833 EN06438 EN16061 EP04422 EP19715 ESG014a.E21_B12 ESG014d.E21_F04 ESG014d.E21_H07 ESG015b.E21_A09 ESG015c.E21_H01 ESG015d.B21.1_F11 ESG017c.E21.3_E06 ESG019c.E21_B08 ESG019d.E21_B09 ESG0114c.B21_E10 ESG0115c.B21_B12 ESG0116b.B21_E06 ESG0116d.B21_C01 ESG0118c.B21_F02 ESG0118d.B21_C08 FGA009F03 FGA010C01 FGC014E05 FGH120F11 FGM003B04 FGM003E01 FGM103A08 FGM103C08 FGM104B04 FGM206D05 FGM210G01 FGM214D04 FGM218E08 FGM218G11 FGM223A09 FGM225E05 FGM227D11 FGM229D04 FGM230H05 FGM231H07 FGM234G09 FGM236C06 FGM302B10 FGM304B12 FGM304D06 FGM307C09 FGM312B04 FGM315C03 FGM315F10 FGM318D04 FGM320C04 FGM323F03 FGM324C04 GH01755 GH02664 GH03224 GH03742 GH04620 GH05796 GH06643 GH06713 GH08237 GH08460 GH08840 GH12280 GH13149 GH13574 GH14551 GH14759 GH15863 GH17551 GH19513 GH21148 GH23038 GH23110 GH24069 GH25804 GH27509 GH27574 GH28303 GM01049 GM02131 GM02863 GM03706 GM03925 GM05778 GM06128 GM07516 GM08120 GM08370 GM09192 GM13244 GM13406 GM14570 GM15955 GM21125 HL01445 HL01649 HL05740 IP02093 IP02094 IP02095 IP02392 IP03653 IP03753 IP03853 IP03953 IP04936 IP07656 IP07841 IP07856 IP07956 IP10949 IP12175 IP12275 IP12815 IP12915 IP13015 LD01409 LD02125 LD02186 LD02521 LD03545 LD03677 LD05517 LD06101 LD06202 LD06503 LD08070 LD10771 LD11206 LD11260 LD13287 LD14811 LD15594 LD16692 LD20782 LD21569 LD21655 LD22913 LD22996 LD23638 LD28331 LD29121 LD29363 LD29539 LD29616 LD29641 LD30007 LD30185 LD30518 LD30641 LD30810 LD31765 LD31827 LD31847 LD31955 LD32041 LD32055 LD32157 LD32365 LD32449 LD32556 LD32604 LD32682 LD33061 LD33245 LD33268 LD33357 LD33591 LD33657 LD34122 LD34255 LD34420 LD34711 LD36018 LD37896 LD39143 LD40296 LD40383 LD41487 LD42493 LD42603 LD43034 LD43450 LD44996 LD45275 LD46426 LD46611 LD47101 LD47415 LD47570 LP01384 LP01526 LP02860 LP02920 LP02968 LP02974 LP03438 LP03566 LP03579 LP03827 LP04527 LP04657 LP04949 LP05040 LP05307 LP06158 LP06891 LP07502 LP07526 LP07773 LP07832 LP09165 LP10055 LP12192 LP12465 LP14412 LP15076 LP17034 LP17203 LP17784 LP22528 RC0-DA0001-120700-012-G08 RC0-DA0001-120700-016-E05 RC0-DL0001-140700-110-D10 RE01057 RE01938 RE01968 RE01985 RE02756 RE03013 RE03033 RE03824 RE03851 RE04258 RE04755 RE05068 RE05403 RE06539 RE06881 RE07557 RE07693 RE08176 RE08809 RE09222 RE09276 RE10537 RE11205 RE11585 RE11684 RE11732 RE12155 RE12350 RE13852 RE13919 RE14806 RE15874 RE15942 RE16385 RE16739 RE17663 RE17673 RE17681 RE18207 RE18801 RE19020 RE19035 RE19735 RE21121 RE21414 RE21508 RE21626 RE21783 RE22226 RE22262 RE22694 RE22734 RE22764 RE23342 RE24154 RE24388 RE24910 RE24914 RE24919 RE25111 RE25214 RE25224 RE25435 RE25559 RE25953 RE26029 RE26135 RE26390 RE26726 RE26784 RE27075 RE27832 RE27903 RE28233 RE29890 RE30004 RE30075 RE30288 RE30392 RE30418 RE30685 RE30945 RE31063 RE31069 RE31185 RE31187 RE31344 RE31364 RE31368 RE31404 RE31559 RE31618 RE31660 RE31774 RE31789 RE31901 RE31941 RE32088 RE32154 RE32444 RE32671 RE32804 RE34045 RE34342 RE34354 RE34441 RE34716 RE35006 RE35032 RE35221 RE35716 RE35780 RE35884 RE35922 RE36066 RE36094 RE36148 RE36150 RE36375 RE36517 RE36645 RE36657 RE36765 RE36956 RE36962 RE37143 RE37166 RE37217 RE37353 RE37407 RE37475 RE37637 RE37869 RE37959 RE38368 RE38645 RE38775 RE39220 RE39623 RE40107 RE40893 RE41343 RE41668 RE41840 RE42314 RE42325 RE42433 RE43720 RE43796 RE44010 RE44550 RE44561 RE44679 RE44789 RE45035 RE45136 RE45284 RE45403 RE45528 RE45886 RE46023 RE46049 RE46863 RE46931 RE47209 RE48542 RE48759 RE49411 RE49791 RE50008 RE50018 RE50307 RE50427 RE50470 RE50536 RE51148 RE51311 RE51819 RE52326 RE53096 RE53173 RE53444 RE53511 RE54191 RE54329 RE55043 RE55618 RE56604 RE56806 RE57344 RE57495 RE58268 RE58515 RE58541 RE58579 RE58592 RE58594 RE60108 RE60202 RE60286 RE60491 RE60503 RE61523 RE61684 RE61706 RE61769 RE62296 RE62462 RE63564 RE63823 RE64063 RE64263 RE64494 RE64520 RE65151 RE65418 RE66101 RE66663 RE66832 RE67205 RE67417 RE67485 RE67524 RE67743 RE67789 RE68910 RE69126 RE69480 RE69551 RE69627 RE69686 RE69792 RE69879 RE69940 RE70108 RE70303 RE70346 RE70422 RE71015 RE71203 RE71443 RE71493 RE72085 RE72501 RE73082 RE73585 RE73676 RE73806 RE73857 RE73879 RE74154 RE74232 RE74293 RE74339 RE74476 RE74520 RE74571 RE74753 RH02818 RH03027 RH03809 RH04345 RH04356 RH04537 RH04870 RH04926 RH04960 RH04976 RH05018 RH05111 RH05120 RH05532 RH05586 RH05925 RH06264 RH06308 RH06369 RH06446 RH06454 RH06492 RH07104 RH07139 RH07591 RH07629 RH07646 RH07751 RH07844 RH07871 RH07926 RH07970 RH07993 RH08022 RH08278 RH08361 RH08375 RH08431 RH08455 RH08576 RH08588 RH08673 RH08674 RH08736 RH08756 RH09271 RH09605 RH09618 RH09760 RH09763 RH09783 RH09811 RH09876 RH09881 RH09891 RH09893 RH09960 RH09964 RH09992 RH10030 RH10074 RH10136 RH10147 RH10180 RH10186 RH10219 RH10334 RH10355 RH10379 RH10420 RH10451 RH10455 RH10487 RH10493 RH10494 RH10507 RH10519 RH10589 RH10590 RH10733 RH10785 RH10817 RH10842 RH10859 RH10890 RH10969 RH11001 RH11105 RH11168 RH11281 RH11286 RH11309 RH11334 RH11519 RH11831 RH11880 RH11887 RH12022 RH12031 RH12365 RH12388 RH12494 RH12790 RH13024 RH13055 RH13087 RH13147 RH13191 RH13635 RH13670 RH13696 RH13710 RH14026 RH14189 RH14376 RH14455 RH14585 RH14614 RH14688 RH14733 RH14769 RH14992 RH15033 RH16165 RH16187 RH16219 RH16332 RH16708 RH16784 RH16844 RH16845 RH16851 RH16858 RH16863 RH16982 RH17164 RH17209 RH17212 RH17219 RH17233 RH17247 RH17314 RH17456 RH17516 RH18172 RH18230 RH18231 RH18239 RH18522 RH18536 RH18704 RH18726 RH18918 RH18924 RH18930 RH18940 RH18977 RH19109 RH19150 RH19205 RH19267 RH19402 RH19688 RH19715 RH19761 RH19783 RH19866 RH19882 RH19906 RH20003 RH20009 RH20076 RH20105 RH20255 RH20262 RH20558 RH20725 RH20780 RH20791 RH20863 RH20946 RH20948 RH20950 RH20987 RH20993 RH21038 RH21308 RH21345 RH21376 RH21425 RH21480 RH21493 RH21586 RH21721 RH21805 RH21862 RH21895 RH22094 RH22111 RH22125 RH22176 RH22223 RH22250 RH22254 RH22271 RH22277 RH22467 RH22480 RH22575 RH22609 RH22640 RH22646 RH22716 RH22736 RH22816 RH22901 RH22904 RH23046 RH23063 RH23117 RH23407 RH23639 RH23686 RH23876 RH23950 RH23989 RH24112 RH24262 RH24293 RH24363 RH24422 RH24446 RH24639 RH25025 RH25215 RH25265 RH25287 RH25412 RH25581 RH25745 RH25832 RH26004 RH26058 RH26141 RH26247 RH26308 RH26313 RH26402 RH26405 RH26613 RH26618 RH26677 RH26767 RH26903 RH27055 RH27056 RH27234 RH27254 RH27350 RH27386 RH27495 RH27551 RH27636 RH27672 RH27716 RH27734 RH27780 RH28101 RH28139 RH28160 RH28214 RH28446 RH28460 RH28495 RH28529 RH28588 RH28866 RH28871 RH29002 RH29180 RH29202 RH29262 RH29284 RH29385 RH29444 RH29446 RH29621 RH29632 RH29814 RH29911 RH30106 RH30236 RH31509 RH32192 RH32313 RH32388 RH32407 RH32412 RH32514 RH32542 RH32557 RH32695 RH32780 RH32804 RH32815 RH32821 RH32846 RH32879 RH32906 RH32951 RH33077 RH33120 RH33124 RH33166 RH33356 RH33357 RH33380 RH33704 RH33743 RH33762 RH33819 RH33846 RH33857 RH33881 RH33885 RH33968 RH34022 RH34024 RH34035 RH34203 RH34206 RH34217 RH34352 RH34380 RH34464 RH34616 RH34659 RH34672 RH34788 RH34906 RH34922 RH34986 RH35127 RH35377 RH35408 RH35648 RH35706 RH35743 RH35758 RH35861 RH35874 RH36064 RH36080 RH36387 RH36471 RH36489 RH36593 RH36813 RH37017 RH37112 RH37340 RH37462 RH37463 RH37618 RH37667 RH37828 RH38136 RH38166 RH38195 RH38265 RH38270 RH38403 RH38467 RH38474 RH38480 RH38495 RH38544 RH38686 RH38704 RH38740 RH38784 RH38818 RH38839 RH38932 RH38944 RH39003 RH39052 RH39092 RH39105 RH39235 RH39248 RH39274 RH39369 RH39457 RH39469 RH39501 RH39510 RH39579 RH39588 RH39903 RH40011 RH40049 RH40184 RH40215 RH40233 RH40488 RH40574 RH40614 RH40643 RH40757 RH40785 RH41332 RH41333 RH41514 RH41655 RH41668 RH41686 RH41806 RH41915 RH42246 RH42277 RH42535 RH42562 RH42580 RH42623 RH42624 RH42636 RH42644 RH42828 RH42929 RH42967 RH42973 RH42981 RH43036 RH43118 RH43238 RH43256 RH43262 RH43281 RH43319 RH43380 RH43384 RH43411 RH43427 RH43438 RH43507 RH43547 RH43559 RH43567 RH43585 RH43593 RH43679 RH43716 RH43719 RH43764 RH43788 RH43829 RH43856 RH43938 RH43985 RH44030 RH44079 RH44122 RH44266 RH44458 RH44487 RH44876 RH44923 RH44952 RH45665 RH45894 RH45915 RH46320 RH46392 RH46492 RH46543 RH46602 RH46622 RH46658 RH47325 RH47515 RH47710 RH47728 RH47834 RH47945 RH47961 RH48128 RH48256 RH48462 RH48469 RH48477 RH48515 RH48622 RH48738 RH48777 RH48844 RH48894 RH48940 RH48994 RH49117 RH49158 RH49314 RH49333 RH49351 RH49364 RH49365 RH49373 RH49396 RH49412 RH49468 RH49494 RH49521 RH49646 RH49850 RH49852 RH49874 RH49877 RH49890 RH49891 RH49905 RH49941 RH49970 RH50069 RH50089 RH50150 RH50178 RH50195 RH50212 RH50240 RH50249 RH50267 RH50290 RH50309 RH50312 RH50372 RH50386 RH50389 RH50437 RH50441 RH50460 RH50505 RH50516 RH50523 RH50575 RH50624 RH50625 RH50676 RH50724 RH50738 RH50759 RH50791 RH50812 RH50833 RH50902 RH50903 RH50952 RH50994 RH51028 RH51068 RH51117 RH51158 RH51183 RH51189 RH51206 RH51220 RH51339 RH51367 RH51376 RH51512 RH51529 RH51572 RH51588 RH51660 RH51810 RH52034 RH52142 RH52195 RH52260 RH52274 RH52275 RH52305 RH52344 RH52442 RH52460 RH52491 RH52677 RH52730 RH52790 RH52865 RH52873 RH52915 RH52946 RH53035 RH53125 RH53188 RH53287 RH53712 RH53738 RH53794 RH54075 RH54088 RH54104 RH54138 RH54173 RH54251 RH54419 RH54438 RH54505 RH54527 RH54531 RH54558 RH54578 RH54607 RH54617 RH54629 RH54631 RH54632 RH54705 RH54791 RH54940 RH54956 RH55015 RH55043 RH55053 RH55135 RH55206 RH55217 RH55231 RH55271 RH55367 RH55385 RH55406 RH55418 RH55422 RH55637 RH55687 RH55814 RH56031 RH56109 RH56137 RH56167 RH56215 RH56236 RH56306 RH56340 RH56371 RH56572 RH56576 RH56588 RH56639 RH56718 RH56876 RH56917 RH56934 RH57136 RH57180 RH57184 RH57548 RH57581 RH57732 RH57752 RH57793 RH57794 RH57918 RH58021 RH58146 RH58260 RH58438 RH58518 RH58557 RH58583 RH58643 RH58748 RH58750 RH58758 RH58762 RH58801 RH58819 RH58822 RH58823 RH58844 RH58846 RH58873 RH58913 RH58946 RH59008 RH59042 RH59075 RH59125 RH59244 RH59361 RH59483 RH59589 RH59839 RH59877 RH59919 RH59952 RH60047 RH60051 RH60389 RH60417 RH60423 RH60439 RH60524 RH60779 RH60789 RH60809 RH60841 RH60878 RH60983 RH61086 RH61196 RH61229 RH61351 RH61390 RH61394 RH61414 RH61470 RH61622 RH61670 RH61704 RH61824 RH61858 RH61953 RH62291 RH62313 RH62317 RH62418 RH62717 RH62911 RH62994 RH63032 RH63050 RH63086 RH63150 RH63154 RH63171 RH63242 RH63253 RH63317 RH63376 RH63417 RH63530 RH63561 RH63579 RH63590 RH63640 RH63684 RH63773 RH63972 RH64023 RH64036 RH64061 RH64071 RH64121 RH64150 RH64168 RH64209 RH64224 RH64261 RH64284 RH64507 RH64528 RH64588 RH64620 RH64738 RH64770 RH64793 RH64837 RH64882 RH64893 RH64894 RH64981 RH65148 RH65149 RH65150 RH65181 RH65662 RH65762 RH65944 RH66084 RH66117 RH66126 RH66180 RH66207 RH66232 RH66265 RH66303 RH66385 RH66492 RH66725 RH66736 RH66778 RH66811 RH66840 RH66845 RH67313 RH67315 RH67824 RH67884 RH67887 RH68003 RH68168 RH68248 RH68339 RH68595 RH68731 RH68870 RH68970 RH69090 RH69205 RH69310 RH69384 RH69413 RH69424 RH69781 RH69811 RH69840 RH69878 RH70043 RH70106 RH70368 RH70378 RH70393 RH70583 RH70638 RH70645 RH70915 RH70928 RH70931 RH70940 RH70960 RH70985 RH71021 RH71036 RH71040 RH71091 RH71094 RH71138 RH71322 RH71404 RH71418 RH71451 RH71452 RH71558 RH71576 RH71658 RH71661 RH71679 RH71715 RH71838 RH71882 RH71895 RH71931 RH71933 RH71966 RH71971 RH71972 RH71980 RH71988 RH72049 RH72095 RH72119 RH72127 RH72349 RH72353 RH72368 RH72382 RH72413 RH72432 RH72446 RH72475 RH72488 RH72648 RH72828 RH72829 RH72938 RH72960 RH73013 RH73024 RH73041 RH73059 RH73145 RH73201 RH73234 RH73241 RH73601 RH73618 RH73631 RH73665 RH73680 RH73784 RH73929 RH73930 RH73955 RH74124 RH74134 RH74215 RH74259 RH74318 RH74319 RH74348 RH74396 RH74557 RH74675 RH74684 RH74750 RH74768 SD01045 SD01126 SD01266 SD01288 SD01371 SD03808 SD04087 SD04207 SD04679 SD04680 SD04831 SD05021 SD05150 SD05708 SD05782 SD07449 SD07676 SD07679 SD08306 SD08382 SD08876 SD09262 SD11159 SD11178 SD11196 SD11280 SD11815 SD11839 SD11874 SD12323 SD12493 SD12538 SD12587 SD12729 SD13616 SD13932 SD14294 SD14389 SD14449 SD14562 SD14763 SD14836 SD15992 SD16053 SD16116 SD16176 SD16313 SD16396 SD16832 SD16879 SD17071 SD18124 SD18225 SD18682 SD19020 SD19133 SD19709 SD19749 SD19761 SD19859 SD20337 SD20360 SD21440 SD21883 SD21922 SD22051 SD23228 SD23429 SD23487 SD24461 SD24872 SD26229 SD26290 SD26305 SD26495 SD26528 SD26541 SD27126 SD27305 SD27813 UT01461
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000556 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36271
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ef1α48D l(2)k07303 (Beaton, 1999.12.12)
Additional comments	The Ef1α48D gene may be derived from the Ef1α100E gene by retroposition. (Betran et al., 2002) "l(2)00248" probably corresponds to "Ef1α48D"; the P{PZ} insertion in the "l(2)0024800248" allele maps only 42bp upstream of the transcription start of the CT24517 transcript of "Ef1α48D". (Misra, 2000.8.25)
Other Comments
	Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Expression of transcript changes with adult age. (Shikama and Brack, 1996) Expression of Ef1α100E or Ef1α48D is not associated with an extended longevity phenotype. (Dudas and Arking, 1994) The report (FBrf0050863) that expression of Ef1α48D correlates with longevity cannot be confirmed by a study of the expression of this gene and of Ef1α100E in lines with extended longevity. (Dudas and Arking, 1994) An important aging control may be exerted at the level of Ef1α48D transcription but heat induced expression of Ef1α48D does not cause increased levels of Ef1α48D mRNA or protein. (Shikama et al., 1994) Enhanced expression of Ef1α48D increases the lifespan of mated females and makes local changes within the bounds of tradeoffs that are given by a pre-existing physiological structure whose basic nature is not changed by the treatment. (Stearns and Kaiser, 1993) Ef1α48D is the housekeeping gene that is needed in all growing cells. Individuals transformed with a P-element containing Ef1α48D sequences under heat shock control have a longer lifespan than wild type flies. (Shepherd et al., 1989) Encodes an α unit of the heterotrimeric protein, elongation factor 1, which promotes the binding of aminoacyl-tRNA to ribosomes. Originally isolated on the basis of its displaying 5 to 10 fold overexpression in females versus males. Ef1α1 is expressed throughout development. The rate of protein synthesis in Drosophila declines with age; this has been attributed to impaired binding of aminoacyl-tRNA to ribosomes, which is promoted by elongation-factor 1 (EF1); transcription of elongation factor-1 mRNA shown to decrease with age; by fifteen days following emergence the level of EF1 mRNA is but a few percent that of newly emerged adults (Webster and Webster, 1984). Transformation with Ef1α1 under the control of heat shock promoter increased the mean life span from 38.2 to 45.1 days at 25oC and from 21.1 to 29.8 days at 29oC (Shepherd, Walldorf, Hug and Gehring, 1989).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058027 NM_165850 RefSeq (Proteins) • NP_477375 NP_725085 DDBJ / EMBL / GenBank • AA802001 AA803896 AAA28526 AAF58608 AAL90260 AAM68698 AAN71645 AC005466 AF006642 AI124257 AI124325 AI542161 AQ025826 AQ026125 AW941393 AY089522 BI581027 BI581028 BT001873 CAA29993 CL632194 CZ476253 G00459 M11744 X06869 Entrez Gene - A searchable database of RefSeq genes. • 36271 UniProtKB/Swiss-Prot • P08736 UniProtKB/TrEMBL • Q8T3U3
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 23024 InterPro domains - A database of protein families, domains, and functional sites • Protein synthesis factor, GTP-binding (IPR000795) Translation elongation factor EFTu/EF1A, C-terminal (IPR004160) Translation elongation factor EFTu/EF1A, domain 2 (IPR004161) Translation elongation factor EF1A, eukaryotic/archaeal (IPR004539) Translation elongation/initiation factor/Ribosomal, beta-barrel (IPR009000) Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (IPR009001)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62056 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000556 DroID - A comprehensive database of gene and protein interactions. • FBgn0000556 DRSC - Results from RNAi screens. • FBgn0000556 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000556 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8280-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000556 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36271 InParanoid A subset of ortholog calls from InParanoid. • AGAP007406-PA Anopheles gambiae (mosquito) At1g07920.1 Arabidopsis thaliana (wall cress) At1g07930.1 Arabidopsis thaliana (wall cress) At1g07940.1 Arabidopsis thaliana (wall cress) At5g60390.1 Arabidopsis thaliana (wall cress) 19314 Batrachochytrium dendrobatidis (chytrid fungus) 122567 Branchiostoma floridae (lancelet) 126207 Branchiostoma floridae (lancelet) 58879 Branchiostoma floridae (lancelet) 91258 Branchiostoma floridae (lancelet) XP_001896880.1 Brugia malayi (roundworm nematode) BGIBMGA003608-PA Bombyx mori (silk worm) ENSBTAP00000019318 Bos taurus (bovine) CAL0004558 Candida albicans (a form of yeast) CAL0004916 Candida albicans (a form of yeast) CN06528 Caenorhabditis brenneri (small nematode) CN09621 Caenorhabditis brenneri (small nematode) CBP04009 Caenorhabditis briggsae (nematode) CE01270 Caenorhabditis elegans (worm) ENSCAFP00000003867 Canis familiaris (dog) ENSCAFP00000027428 Canis familiaris (dog) CAGL0D01188g Candida glabrata (haploid yeast) CAGL0K07832g Candida glabrata (haploid yeast) JA02926 Caenorhabditis japonica (nematode) cn13119 Cryptococcus neoformans (yeast-like fungus) CPIJ009303 Culex pipens (mosquito) ENSCPOP00000003669 Cavia porcellus (guinea pig) 132905 Chlamidomonas reinhardtii (green alga) 134382 Chlamidomonas reinhardtii (green alga) RP42119 Caenorhabditis remanei (nematode) RP44027 Caenorhabditis remanei (nematode) ENSCSAVP00000010846 Ciona savignyi (sedentary tunicate) DEHA2D02376g Debaryomyces Hansenii (yeast) DEHA2F03828g Debaryomyces Hansenii (yeast) 300308 Daphnia pulex (daphnia) ENSDARP00000006339 Danio rerio (zebra fish) ENSECAP00000003695 Equus caballus (horse) ENSECAP00000018148 Equus caballus (horse) XP_648361 Entamoeba histolytica (anaerobic protozoan) XP_648717 Entamoeba histolytica (anaerobic protozoan) XP_651869 Entamoeba histolytica (anaerobic protozoan) ENSGALP00000025606 Gallus gallus (chicken) ENSP00000339063 Homo sapiens (human) KLLA0B08998g Kluyveromyces lactis (yeast) 239271 Lottia gigantea (owl limpet) LmjF17.0080 Leishmania major (virus) LmjF17.0081 Leishmania major (virus) LmjF17.0082 Leishmania major (virus) LmjF17.0083 Leishmania major (virus) LmjF17.0084 Leishmania major (virus) LmjF17.0085 Leishmania major (virus) LmjF17.0086 Leishmania major (virus) ENSMODP00000023121 Monodelphis domestica (gray opossum) ENSMMUP00000006451 Macaca mulatta (rhesus monkey) ENSMUSP00000042457 Mus musculus (house mouse) 247215 Nematostella vectensis (starlet anemone) ENSOANP00000007773 Ornithorynchus anatinus (platypus) ENSORLP00000009506 Oryzias latipes (japanese killifish) ENSORLP00000009543 Oryzias latipes (japanese killifish) LOC_Os03g08010.1 Oryza sativa (asian rice) LOC_Os03g08020.1 Oryza sativa (asian rice) LOC_Os03g08050.1 Oryza sativa (asian rice) LOC_Os03g08060.1 Oryza sativa (asian rice) PP18988 Pristionchus pacificus (nematode) 104509 Physcomitrella patens (moss) 158894 Physcomitrella patens (moss) 158916 Physcomitrella patens (moss) 163704 Physcomitrella patens (moss) 182696 Physcomitrella patens (moss) 210098 Physcomitrella patens (moss) 212963 Physcomitrella patens (moss) 76520 Physcomitrella patens (moss) ENSPPYP00000018778 Pongo pygmaeus (orangutan) ENSPPYP00000018935 Pongo pygmaeus (orangutan) 655943 Populus trichocarpa (black cottonwood) 655949 Populus trichocarpa (black cottonwood) 720367 Populus trichocarpa (black cottonwood) ENSPTRP00000045593 Pan troglodytes (chimpanzee) ENSRNOP00000013608 Rattus norvegicus (norway rat) ENSRNOP00000017180 Rattus norvegicus (norway rat) 146828 Sorghum bicolor (sorghum) 150010 Sorghum bicolor (sorghum) 4865263 Sorghum bicolor (sorghum) 4994745 Sorghum bicolor (sorghum) YBR118W Saccharomyces cerevisiae (budding yeast) YPR080W Saccharomyces cerevisiae (budding yeast) SPAC23A1.10 Schizosaccharomyces pombe (fission yeast) SPBC839.15c Schizosaccharomyces pombe (fission yeast) SPCC794.09c Schizosaccharomyces pombe (fission yeast) XP_001176381.1 Strongylocentrotus purpuratus (purple sea urchin) 36635 Trichoplax adhaerens (metazoa) NP_001107835.1 Tribolium castaneum (red flour beetle) Tc00.1047053510119.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511367.360 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511367.370 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511369.20 Trypanosoma cruzi (parasitic trypanosome) 96.m00145 Tetrahymena thermophila (ciliate protozoa) 82490.m00257 Trichomonas vaginalis (parasitic flagellated protozoan) 96267.m00166 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002561 Xenopus tropicalis (frog) YALI0C09141g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36271 modMine - Data generated by the modENCODE project. • FBgn0000556 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230135 FBgn0224033 FBgn0205055 FBgn0182584 FBgn0080940 FBgn0142692 FBgn0128940 FBgn0112420 FBgn0090138 CPIJ009303 BGIBMGA003608 AGAP007406 GLEAN_01880
Synonyms & Secondary IDs ( 42 )
Reported As
Symbol Synonym	1275 (Harvie et al., 1998) anon-EST:Liang-1.17   anon-EST:Liang-2.46   CG8280 (Scherfer et al., 2004, Kang et al., 2002, Goldstein and Gunawardena, 2000, Lasko, 2000, Cermelli et al., 2006, Huang et al., 2005, Quinones-Coello, 2007, Worringer et al., 2009, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2010.12.1, Ling and Salvaterra, 2011, Cammarato et al., 2011) clone 1.17 (Liang and Biggin, 1998) clone 2.46 (Liang and Biggin, 1998) Dm0084 (Teeter et al., 2000) DmEF1 (Grinblat et al., 1989) eEF1α (Lasko, 2000) EF (Giribet et al., 2001, Guichard et al., 2006) EF-1 (Arking et al., 1996) EF-1a (Harvie and Bryant, 1997) EF-1a (Shikama et al., 1992) Ef1a10 (Kliman and Eyre-Walker, 1998) Ef1a48D (Thomson et al., 2008) EF1-alpha (Hilger et al., 2009) Ef1alpha48D (Beller et al., 2006, Giot et al., 2003, Langille and Clark, 2007, Quinones-Coello, 2007, Bakal et al., 2007, Kadam et al., 2009, Accardo et al., 2004, Wasbrough et al., 2010) ef-1α (Wang et al., 2004) EF-1α (Tycowski and Steitz, 2001, Johnson, 1997, Kaiser et al., 1997, Tower, 1996, Rose and Archer, 1996, Ackermann and Brack, 1996, Shmookler Reis and Ebert, 1996, Stearns and Kaiser, 1996, Gasser et al., 1995, Dudas and Arking, 1994, Ackermann et al., 1994, Stearns et al., 1993, Nusbaum and Rose, 1994, Stearns and Kaiser, 1993, Shepherd et al., 1989) EF1α (van Steensel et al., 2001, Leips and Mackay, 2000, Takada et al., 2000, Tatar, 1999, Fan et al., 2010) EF1-α (Rose, 1999) Ef1α1   EF1α48D (Jasper et al., 2002, Worringer et al., 2009) Ef1α48D (Stuart et al., 2007, Hoopfer et al., 2008, Dietzl et al., 2007, Ling and Salvaterra, 2011) EF1α 48D (Fan et al., 2010) Ef1α48E (Betran et al., 2002) EF-1αF (Liang and Biggin, 1998) EF-1αF1 (Kutach and Kadonaga, 2000) EF-1α F1 (Shikama and Brack, 1996) EF-1αF1 (Harvie et al., 1998) Efalpha48D (Cermelli et al., 2006) F1 (Shepherd et al., 1989, Henikoff and Wallace, 1988, ) F1 EF-1α (Donati et al., 1996) l(2)1275 (Harvie, 1997.6.4) l(2)01275   l(2)k07303 (BDGP Project Members, 1994-1999, )
Name Synonym	Elongation factor 1 alpha (Ling and Salvaterra, 2011) Elongation factor 1 alpha 48D (Cermelli et al., 2006) Elongation factor 1alpha48D (Cammarato et al., 2011) elongation factor 1-alpha F1 (Hovemann, 1988.2.18) Elongation factor 1α48D   Translational elongation factor1 (Kang et al., 2002)
Secondary FlyBase IDs
	FBgn0010480 FBgn0022092
References ( 101 )
Generate a list of	All references relating to this gene ( 101 )
List References by type	Research paper  ( 50 ) Supplementary material  ( 12 ) Review  ( 9 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 7 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Letter  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Fan et al., 2010, Genetics 184(1): 141--154 Drosophila translational elongation factor-1{gamma} is modified in response to DOA kinase activity and is essential for cellular viability. [FBrf0209673] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...