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Gene Dmel\egl

General Information
Symbol	Dmel\egl	Species	D. melanogaster
Name	egalitarian	Annotation symbol	CG4051
Feature type	protein_coding_gene	FlyBase ID	FBgn0000562
Gene Model Status	Current	Stock availability	14 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-105
Cytogenetic map	59F7-59F7	Sequence location	2R:19,622,427..19,634,348 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene egalitarian is referred to in FlyBase by the symbol Dmel\egl (CG4051, FBgn0000562). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: germarium-derived oocyte fate determination; intracellular mRNA localization; oogenesis; mRNA transport. 28 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; organ system; anatomical structure; organelle; intracellular organelle part; portion of tissue; intracellular non-membrane-bounded organelle; vitellarium; nuclear part; centrosome; synapse; karyosome. It has one annotated transcript and one annotated polypeptide. Protein features are: 3'-5' exonuclease domain; Ribonuclease H-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641303_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of egl. Gene sequence location is 2R:19622427..19634348.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	egl: egalitarian (T. Schupbach) Female sterile. Defect in cell fate detectable in anterior germarium. In contrast to wild-type, in all egl alleles all sixteen cells per cyst enter pachytene; subsequently all sixteen revert to nurse-cell morphology and behavior (Carpenter). Egg chambers increase in volume along the ovariole, but do not take up yolk. No chorion is formed. BicD/+ females simultaneously heterozygous for egl1 or egl2 fail to form double-abdomen embryos (Mohler and Wieschaus, 1986, Genetics 112: 803-22).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59F7-59F7   Limits computationally determined from genome sequence between P{PZ}apt03041 and P{EP}eglEP938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 59F6-59F8     (Mach, 1997.1.22)
Experimentally Determined Recombination Data
Location	2-105
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\egl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) egl-RB FBtr0114586  NM_166623   4424   1004
Additional Transcript Data & Comments
Reported size (kB)	4.6 (northern blot) (Mach and Lehmann, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein egl-PB   FBpp0113078   112.1   1004   7.29     NP_726360   AAF47054
Additional Polypeptide Data & Comments
Reported size (kDa)	874 (aa); 125 (kD observed); 98 (kD predicted) (Mach and Lehmann, 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • 3'-5' exonuclease domain (IPR002562) Ribonuclease H-like domain (IPR012337)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA949965   AE013599 AAF47054   AI063265   AI063972   AQ024993   BI170944   BI237220   BI239063   BI375304   BI482928   BI578614   BI620205   BP556662   BT009999 AAQ22468   CK658064   CO186103   CO186107   CO186189   CO264086   CO267076   CO281632   CO297057   CO297654   CO315320   CO317455   CO319227   CO322265   CO323498   CO331549   CO332376   CZ473617   CZ478647   CZ487322   EC064294   EC068508   EC073439   EC084368   EC084751   EC085976   EC199891   EC200690   EC208807   EC209718   EC215470   EC217620   EC226709   EC227121   EC236351   EC239087   EC239649   EC240688   ES691090   ES691091   ES691093   ES691094   ES694205   EV578997   EV599547   GH943113   GH953933   GH957317   GH960919   GH961412   GH963118   GH964707   GH978180   GH981616   U86404 AAB49975
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W1K4 Q7YU43 P92030
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 9 -- 10   organism | pair rule expression pattern   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   atrium | precursor   (Fisher et al., 2012) Comment:reported as atrium primordium clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) circular visceral muscle fiber   (Fisher et al., 2012) dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) adult stage & oogenesis   oocyte   (Mach and Lehmann, 1997)
Additional Descriptive Data
	egl RNA is enriched in single cells when the 16-cell cyst forms in region 2A of the germarium. Between stages S2 and S7, egl RNA is concentrated at the posterior cortex of the oocyte. As the oocyte starts to accumulate yolk, egl transcripts localize to an anterior ring at the nurse cell-oocyte boundary. By stage S10, they are distributed evenly throughout the oocyte and persist in the oocyte until early embryogenesis. (Mach and Lehmann, 1997)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   germarium   (Mach and Lehmann, 1997) oogenesis   germarium region 3 & oocyte | posterior   (Vaccari and Ephrussi, 2002) germarium region 1 & germline cyst   (Vaccari and Ephrussi, 2002) germarium region 2b & presumptive oocyte | anterior   (Vaccari and Ephrussi, 2002) germarium region 2a & presumptive oocyte | anterior   (Vaccari and Ephrussi, 2002)
Additional Descriptive Data
	The BicD and egl proteins, as previously described for the orb protein, accumulate in the presumptive oocyte following fusome disassembly in germarium region 2a during oocyte specification and are relocalized to the posterior of the oocyte between germarium regions 2b and 3 during oocyte polarization. (Vaccari and Ephrussi, 2002) egl protein is first detected in the germarium and is evenly distributed in the newly formed 16-cell cyst. By stage S1 of oogenesis, it localizes to a single cell, the future oocyte. From stages S2 to S7 egl protein is enriched at the posterior cortex of the oocyte, wherever the oocyte abuts the follicle cells. At stage S8, it shifts to the anterior cortex in a ring around the margin of the oocyte where the oocyte, nurse cells, and follicle cells meet. Staining is particularly pronounced around the oocyte nucleus. No protein is detec ed in the oocyte after stage S10. egl protein distribution in oocytes closely resembles the distribution of the minus end of microtubules. It was shown that disrupting microtubule organization abolishes egl protein localization. In addition, egl protein and BcD protein were found to have identical distributions during all stages of oogenesis. Localization of egl protein depends on BicD protein and vice versa. (Mach and Lehmann, 1997)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland    552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop    505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland    653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland  (552.2) Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop  505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland  (653.2) Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland    552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop    505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland    653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland    552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop    505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland    653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland    552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop    505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland    653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland  552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop  505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland  653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland    552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop    505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland    653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    91.125 Larval Midgut    422.4 Larval Hindgut    396.7 Larval Malpighian Tubules    304.3 Larval Fat Body    93 Larval Salivary Gland    552.2 Larval Trachea    214.25 Larval Carcass    236.8 Adult Head    188.8 Adult Eye    189.225 Adult Brain    112.4 Adult Thoracic-Abdominal Ganglion    178.5 Adult Crop    505.2 Adult Midgut    221.6 Adult Hindgut    328.7 Adult Malpighian Tubules    318.3 Adult Fat Body    140 Adult Salivary Gland    653.2 Adult Heart    90.3 Adult VirginFemale Spermatheca    129.8 Adult InseminatedFemale Spermatheca    151.5 Adult Ovary    322.3 Adult Testis    30.7 Adult Male Accessory Gland    137.2 Adult Carcass    239.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    188.8   NA  Eye    189.225   NA  Brain    112.4   91.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    178.5   NA  Crop    505.2   422.4  Midgut    221.6   396.7  Hindgut    328.7   304.3  Malpighian Tubules    318.3   93  Fat Body    140   552.2  Salivary Gland    653.2   NA  Heart    90.3   214.25  Trachea    NA   NA  VirginFemale Spermatheca    129.8   NA  InseminatedFemale Spermatheca    151.5   NA  Ovary    322.3   NA  Testis    30.7   NA  Male Accessory Gland    137.2   236.8  Carcass    239.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    57 ovary, mated 4-day female    50 testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male  (28) head, mated 4-day male    22 head, mated 20-day male  (27) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (30) digestive system, larvae L3 wandering  26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (50) testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    57 ovary, mated 4-day female    50 testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    57 ovary, mated 4-day female    50 testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    57 ovary, mated 4-day female    50 testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male  28 head, mated 4-day male    22 head, mated 20-day male  27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  30 digestive system, larvae L3 wandering  26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (50) testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    57 ovary, mated 4-day female    50 testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    9 central nervous system, pupae P8    13 head, virgin 1-day female    20 head, virgin 4-day female    18 head, virgin 20-day female    19 head, mated 1-day female    18 head, mated 4-day female    16 head, mated 20-day female    16 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    27 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    30 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    7 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    24 carcass, 1-day adult    19 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    57 ovary, mated 4-day female    50 testis, mated 4-day male    3 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr    28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP    28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day    35 adult female 05day    43 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (60) embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr  (28) embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP  (28) adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day  (35) adult female 05day  (43) adult female 30day  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr    28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP    28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day    35 adult female 05day    43 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr    28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP    28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day    35 adult female 05day    43 adult female 30day    44 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr    28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP    28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day    35 adult female 05day    43 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (60) embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr  28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP  28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day  (35) adult female 05day  (43) adult female 30day  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr    28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP    28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day    35 adult female 05day    43 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    18 embryo 04-06hr    4 embryo 06-08hr    8 embryo 08-10hr    21 embryo 10-12hr    28 embryo 12-14hr    24 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    16 embryo 22-24hr    17 larva L1    16 larva L2    23 larva L3 12hr old    19 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    22 white prepupae new    23 white prepupae 12hr    17 white prepupae 24hr    20 pupae 2d postWPP    23 pupae 3d postWPP    20 pupae 4d postWPP    28 adult male 01day    22 adult male 05day    21 adult male 30day    20 adult female 01day    35 adult female 05day    43 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    16 embryonic 1182-4H    26 embryonic GM2    20 embryonic Kc167    26 embryonic S1    31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    16 embryonic 1182-4H  26 embryonic GM2    20 embryonic Kc167  26 embryonic S1  (31) embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3  (31) eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    16 embryonic 1182-4H    26 embryonic GM2    20 embryonic Kc167    26 embryonic S1    31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    16 embryonic 1182-4H    26 embryonic GM2    20 embryonic Kc167    26 embryonic S1    31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    16 embryonic 1182-4H    26 embryonic GM2    20 embryonic Kc167    26 embryonic S1    31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    16 embryonic 1182-4H  26 embryonic GM2    20 embryonic Kc167  26 embryonic S1  31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3  31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    16 embryonic 1182-4H    26 embryonic GM2    20 embryonic Kc167    26 embryonic S1    31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    16 embryonic 1182-4H    26 embryonic GM2    20 embryonic Kc167    26 embryonic S1    31 embryonic S3    18 leg disc CME L1    15 wing disc CME-W2    14 wing disc ML-DmD8    13 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    14 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    24 ovary fGS/OSS    14 ovary OSC    10 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  (30) Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (45) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  30 Cadmium 100 mM 48 hrs, 4-day adult  (47) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (45) Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    47 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    45 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • RE33408 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000562 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4051-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for egl Stages(s) 1-3 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable egl1286 viable, with Scer\GAL4pnr-MD237 eglGD11202 Sterility Allele female sterile egl1 egl2 egl3 egl4 egl5 female sterile | recessive egl1 egl2 egl4 egl5 Other Phenotypes Allele neuroanatomy defective eglunspecified neuroanatomy defective, with Scer\GAL4elav-C155 eglEP938 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 eglEP938 wild-type eglotu.PM Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 eglEP938 border follicle cell, with Scer\GAL4upd eglKK105186 bouton eglunspecified centrosome (with egl1) egl2 centrosome (with egl2) egl1 egg chamber egl1 egl3e egldlc2pt.otu egg chamber (with egl1) egl4 egg chamber (with egl4) egl1 embryonic neuroblast (with egl1) egl3e embryonic neuroblast (with egl3e) egl1 embryonic neuroblast & spindle (with egl1) egl3e embryonic neuroblast & spindle (with egl3e) egl1 germarium region 2a (with egl1) egl2 germarium region 2a (with egl2) egl1 germline cyst egl1 egl2 egl4 egl5 germline cyst (with egl1) egl2 germline cyst (with egl2) egl1 karyosome, with egl3e egldlc2pt.otu karyosome, with egldlc2pt.otu egl3e karyosome (with egl3e) egldlc2pt.otu karyosome (with egldlc2pt.otu) egl3e lipid droplet, with Scer\GAL4nos.UTR.T:Hsim\VP16 eglScer\UAS.P\T.cBa microtubule (with Df(2R)bw-S46) egl1 microtubule organizing center (with Df(2R)bw-S46) egl1 nurse cell | ectopic egl1 nurse cell | ectopic (with egl1) egl2 nurse cell | ectopic (with egl2) egl1 nurse cell | supernumerary egl1 nurse cell ring canal egl1 egl2 egl4 egl5 oocyte egl1 oocyte (with egl1) egl2 oocyte (with egl2) egl1 ovary egl1 egl2 egl3e egl4 egl5 egldlc2pt.otu ovary (with egl1) egl4 ovary (with egl4) egl1 synapse eglunspecified synaptonemal complex egl3e egldlc2pt.otu synaptonemal complex (with egl1) egl2 egl4 synaptonemal complex (with egl2) egl1 synaptonemal complex (with egl4) egl1 synaptonemal complex | ectopic egl1 synaptonemal complex | ectopic (with egl1) egl2 synaptonemal complex | ectopic (with egl2) egl1 vitellarium egl1 egl2 egl4 egl5
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of egl Class Mutagen Stocks Known lesion egl1286 gamma ray 2 -- egl1 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes egld03893 P-element activity 1 -- egle00801 piggyBac transposase 1 -- eglEP938 P-element activity 1 Yes eglf04558 1 -- eglf04762 piggyBac transposase 1 -- eglMI03856 1 -- eglNP7021 1 -- egl2 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- egl1287 0 -- egl2b 0 -- egl2e 0 -- egl3 ethyl methanesulfonate 0 Yes egl3e 0 Yes egl4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes egl4e 0 Yes egl5 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- eglunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of egl Class Mutagen Stocks Known lesion eglGD11202 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eglGL01170 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eglHM05180 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eglKK105186 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes egldlc2pt.otu in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes eglotu.PM in vitro construct - regulatory fusion 0 Yes eglScer\UAS.P\T.cBa in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eglT:Hsap\MYC in vitro construct - coding region fusion 0 Yes egltub.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)bw5 (Fitzpatrick et al., 1995) Df(2R)bw-D23 (Schupbach and Wieschaus, 1991, Carpenter, 1994) Df(2R)bw-HB132 (Moore, 1997) Df(2R)bw-S46 (Schupbach and Wieschaus, 1991, Carpenter, 1994) Df(2R)bw-WI366 (Moore, 1997) Df(2R)bw-WI3121 (Moore, 1997) Df(2R)bw-WI3128 (Moore, 1997) Df(2R)bw-WI3140 (Moore, 1997)
Not disrupted in	Df(2R)bw-DRj (Mach and Lehmann, 1997) Df(2R)bw-WI320 (Moore, 1997) Df(2R)bw-WI379 (Moore, 1997) Df(2R)bw-WI3118 (Moore, 1997) Df(2R)bw-WI3129 (Moore, 1997) Df(2R)bw-WI3133 (Moore, 1997) Df(2R)or-BR11 (Mach and Lehmann, 1997, Moore, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11202} NA P{KK105186} NA P{TRiP.GL01170} NA P{TRiP.HM05180} NA P{UASp-egl.B} NA characterization construct P{egl.dlc2pt} NA P{egl-Myc} NA P{otu-egl} NA P{tub-egl.EGFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}eglEP938 NA P{XP}egld03893 NA insertion of enhancer trap binary system P{GawB}eglNP7021 No miscellaneous insertions Mi{MIC}eglMI03856 NA PBac{RB}egle00801 NA PBac{WH}eglf04558 NA PBac{WH}eglf04762 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from direct assay (Dienstbier et al., 2009)
Biological Process
CV term Evidence References
germarium-derived oocyte fate determination inferred from mutant phenotype (Navarro et al., 2004) intracellular mRNA localization inferred from mutant phenotype (Hughes et al., 2004) mRNA transport inferred from direct assay (Delanoue and Davis, 2005) inferred from mutant phenotype (Bullock et al., 2006) oogenesis inferred from direct assay (Mach and Lehmann, 1997) inferred from mutant phenotype (Schupbach and Wieschaus, 1991, Carpenter, 1994)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
3'-5' exonuclease activity inferred from electronic annotation with InterPro:IPR002562 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
germarium-derived oocyte fate determination non-traceable author statement (Tekotte and Davis, 2002) traceable author statement (Mahowald, 2001, Deng and Lin, 2001) intracellular mRNA localization traceable author statement (Tekotte and Davis, 2002) nucleobase-containing compound metabolic process inferred from electronic annotation with InterPro:IPR002562 (FlyBase Curators et al., 2004-) oocyte dorsal/ventral axis specification traceable author statement (Deng and Lin, 2001) oocyte microtubule cytoskeleton organization traceable author statement (Johnstone and Lasko, 2001) oocyte nucleus migration involved in oocyte dorsal/ventral axis specification traceable author statement (Cooperstock and Lipshitz, 1997) oogenesis non-traceable author statement (Mach and Lehmann, 1992) traceable author statement (Manheim et al., 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
egl - CG6123 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) egl - CG7686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) egl - CanA1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) egl - Hakai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) egl - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) egl - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions egl allele Gene References egl1 eve (Bullock et al., 2004) ftz (Bullock et al., 2004) h (Bullock et al., 2004) insc (Hughes et al., 2004) egl2b BicD (Mach and Lehmann, 1997) egl2e BicD (Mach and Lehmann, 1997) egl3e BicD (Mach and Lehmann, 1997) eve (Bullock et al., 2004) ftz (Bullock et al., 2004) h (Bullock et al., 2004) insc (Hughes et al., 2004) egl4e BicD (Mach and Lehmann, 1997) unspecified BicD (Mach and Lehmann, 1992)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63353 DroID - A comprehensive database of gene and protein interactions. • FBgn0000562 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37757
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6907VC, EOG676KMC Dipteran inclusive ortholog search EOG6MW8F2 Insect inclusive ortholog search EOG62BW4G Arthropod inclusive ortholog search EOG60GB5R Metazoa inclusive ortholog search EOG6BPD4V
Orthologs in Drosophila Species (EOG6907VC, EOG676KMC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\egl     Drosophila simulans   Dsim\GD25020 Y   Drosophila sechellia   Dsec\GM15515 Y   Drosophila erecta   Dere\GG20003 Y   Drosophila yakuba   Dyak\GE11539 Y   Drosophila ananassae   Dana\GF11823 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30496 Y   Drosophila persimilis   Dper\GL17589 Y   Drosophila willistoni   Dwil\GK23167 Y   Drosophila virilis   Dvir\GJ18283 Y   Drosophila mojavensis   Dmoj\GI19770 Y   Drosophila grimshawi   Dgri\GH20576 Y
Orthologs in non-Drosophila Dipterans (EOG6MW8F2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002475   Anopheles gambiae Malaria mosquito  Agam\AGAP005155   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006999   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010836
Orthologs in non-Dipteran Insects (EOG62BW4G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44828   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008942   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23523   Atta cephalotes Leafcutter ant  Acep\ACEP17539   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18733   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18301   Linepithema humile Argentine ant  Lhum\LH23793   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22225   Solenopsis invicta Red fire ant  Sinv\SINV25624   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009945   Bombyx mori Silkmoth  Bmor\BGIBMGA013226   Pediculus humanus Human body louse  Phum\PHUM155110   Tribolium castaneum Red flour beetle  Tcas\egl
Orthologs in non-Insect Arthropods (EOG60GB5R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Igf2bp1   Ixodes scapularis Deer tick  Isca\ISCW022591
Orthologs in non-Arthropod Metazoa (EOG6BPD4V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\egal-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017115gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002877gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000823gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017776gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017637gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017638gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013840gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022640gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010544gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25020 Drosophila sechellia Dsec\GM15515 Drosophila erecta Dere\GG20003 Drosophila yakuba Dyak\GE11539 Drosophila ananassae Dana\GF11823 Drosophila pseudoobscura pseudoobscura Dpse\GA30496 Drosophila persimilis Dper\GL17589 Drosophila willistoni Dwil\GK23167 Drosophila virilis Dvir\GJ18283 Drosophila mojavensis Dmoj\GI19770 Drosophila grimshawi Dgri\GH20576
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	32006 egl1 sp1/SM6a 17205 w1118; P{EP}eglEP938/CyO 28969 y1 v1; P{TRiP.HM05180}attP2 42982 y1 w*; Mi{MIC}eglMI03856 3459 c* egl1286 sp* bs*/SM5
Harvard	- P{XP}egld03893 - PBac{RB}egle00801 - PBac{WH}eglf04558 - PBac{WH}eglf04762
Kyoto	107050 c* egl1286 sp* bs*/SM5
VDRC	v104141 P{KK105186}VIE-260B v21779 w1118 P{GD11202}v21779
	More stocks available...
Genomic Clones ( 1 )
	BACR02E09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE33408
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02842 GH04206 LD28547 LP14595 RE12577 RE35454 RE63078 RE65737 RE72505 RH51286
Other clones	29215 33775 39810 42795 53269 62368 64022 80994 82481 158240 163981 165806 175995 273481 CK01.15D.E6 CK01.15D.H6 CK01.17B.A12 CK01.133A.A8 Dmel_dig_015185_0619_3300 Dmel_neb_005230_0940_0654 EK015851 EK015863 EK016736 EK137346 EK148645 EK157740 EK170261 EK187753 EK190623 EK215822 EK261037 EK268215 EK276848 EK300512 EK303306 FGM304G11 RP004061288 RP004121769 RP004231029 RP004253507 RP004263502 RP004501491 RP004517918 RP004535747 RP004540361
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37757
Antibody Information
	polyclonal (Mach and Lehmann, 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: egl CG4051 (Zhang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Despite lacking a canonical RNA-binding motif, egl protein directly recognises active mRNA localisation elements. (Dienstbier et al., 2009) egl promotes the initiation of rapid minus-end directed movement of mRNAs along microtubules. (Bullock et al., 2006) egl mediates the apical localisation of insc mRNA in embryonic neuroblasts. (Hughes et al., 2004) ctp interacts with egl through a ctp interaction domain near the C terminus of egl and a well established binding motif in ctp. (Navarro et al., 2004) par-1 appears to act on the cytoskeleton to affect polarisation within the oocyte in conjunction with BicD, egl and dynein. (Vaccari and Ephrussi, 2002) All of the cells in the female germline cyst form synaptonemal complex in egl mutants. (Huynh and St. Johnston, 2000) BicD exists as a multimeric protein complex consisting of egl and at least two BicD monomers. (Oh et al., 2000) egl protein colocalises with BicD protein to the oocyte in three stages that correlate with the stepwise polarization of the oocyte. Immunoprecipitation experiments show that both proteins are part of a protein complex. Results propose that the egl-BicD protein complex links microtubule polarity and RNA transport. (Mach and Lehmann, 1997) Oocyte determination requires egl function in the germ line, but not in the surrounding follicle cells. During early oogenesis the egl-BicD protein complex is required to transport factors promoting oocyte differentiation; during later stages the complex directs the sorting of RNA molecules required for anterior-posterior and dorsoventral patterning of the embryo. (Mach and Lehmann, 1997) The egl locus is responsible for two functions in cell fate choice in oogenesis: early on it is necessary for inhibition of meiotic entry in the "obligate" pro-nurse cells; later it is necessary for meiotic maintenance in the "winning" pro-oocyte. Both roles can be attributed to a single function by invoking gradients through the early cyst; the egl+ function appears to be required for the normal function of these gradients. (Carpenter, 1994) egl mutants have disrupted microtubule cytoskeletons and fail to differentiate an oocyte. (Knowles and Cooley, 1994) Recessive mutations at egl and BicD, and microtubule assembly inhibitors, disrupt the formation and maintenance of the single polarized microtubule cytoskeleton that connects the oocyte to the 15 nurse cells at the time the oocyte is determined. (Theurkauf et al., 1993) Alleles of egl and BicD were used to show that the differentiation of an oocyte is required for maintainance but not establishment of follicle polarity. (Bohrmann et al., 1992) In egl mutant ovaries the cell which would normally develop as an oocyte instead forms a 16th nurse cell. egl acts as a dominant suppressor of BicD. (Mach and Lehmann, 1992) egl is required for oogenesis and the determination of polarity within the embryo. (Mach and Lehmann, 1992) The egl locus affects early oogenesis: mutations cause the production of few, defective germ cells. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166623 RefSeq (Proteins) • NP_726360 DDBJ / EMBL / GenBank • AAB49975 AAF47054 AAQ22468 AQ024993 BI237220 BT009999 CZ473617 CZ478647 CZ487322 U86404 Entrez Gene - A searchable database of RefSeq genes. • 37757 UniProtKB/TrEMBL • P92030 Q7YU43 Q9W1K4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • 3'-5' exonuclease domain (IPR002562) Ribonuclease H-like domain (IPR012337) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE33408
Linkouts
	BioGRID - A database of protein and genetic interactions • 63353 DroID - A comprehensive database of gene and protein interactions. • FBgn0000562 DRSC - Results from RNAi screens. • FBgn0000562 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000562 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4051-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37757 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37757 modMine - Data generated by the modENCODE project. • FBgn0000562
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG4051 (Kraut et al., 2001, Kraut et al., 2001, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) egal (McKearin, 1997) egl (Turner et al., 2008, Delanoue and Davis, 2005, Bullock et al., 2006, Mirouse et al., 2006, Navarro et al., 2004, Wodarz, 2002, Schottenfeld-Roames and Ghabrial, 2012, Delanoue et al., 2007, Flatt et al., 2008, Roper, 2007, Maybeck and Röper, 2009, Dienstbier et al., 2009, Li et al., 2010, Barnes et al., 2007, Mukherjee et al., 2006, Lewandowski et al., 2010, Vazquez-Pianzola et al., 2011) Egl (Hughes et al., 2003, Bullock et al., 2006, Navarro et al., 2004, Clark et al., 2007, Shav-Tal and Singer, 2005, Liu et al., 2011, Parma et al., 2007, Navarro et al., 2009, Li et al., 2008, Van De Bor et al., 2011, Bianco et al., 2010) EGL (Wang et al., 2010)
Name Synonym	egalitarian (Flatt et al., 2008, Maybeck and Röper, 2009, Barnes et al., 2007, Mukherjee et al., 2006, Cognigni et al., 2011) Egalitarian (Bullock et al., 2006, Navarro et al., 2004, Shav-Tal and Singer, 2005, Dienstbier et al., 2009, Li et al., 2010, Li et al., 2008, Bianco et al., 2010, Wang et al., 2010, Vazquez-Pianzola et al., 2011)
Secondary FlyBase IDs
References ( 153 )
Generate a list of	All references relating to this gene ( 153 )
List References by type	Research paper  ( 75 ) Supplementary material  ( 5 ) Review  ( 35 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 21 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Thesis  ( 1 )
Recent research papers ( 5 )
	Schottenfeld-Roames and Ghabrial, 2012, Nat. Cell Biol. 14(4): 386--393 Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth. [FBrf0217936] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Liu et al., 2011, Curr. Biol. 21(22): 1888--1893 The Exoribonuclease Nibbler Controls 3' End Processing of MicroRNAs in Drosophila. [FBrf0216782] Van De Bor et al., 2011, Development 138(7): 1383--1393 Asymmetric localisation of cytokine mRNA is essential for JAK/STAT activation during cell invasiveness. [FBrf0213214] Vazquez-Pianzola et al., 2011, Dev. Biol. 357(2): 404--418 Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation. [FBrf0214798] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...