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Gene Dmel\Eh

General Information
Symbol	Dmel\Eh	Species	D. melanogaster
Name	Eclosion hormone	Annotation symbol	CG5400
Feature type	protein_coding_gene	FlyBase ID	FBgn0000564
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	DMEHAB
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90B1-90B1	Sequence location	3R:13,272,364..13,274,580 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Eclosion hormone is referred to in FlyBase by the symbol Dmel\Eh (CG5400, FBgn0000564). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: eclosion hormone activity. Based on sequence similarity, it is predicted to be involved in the biological process: regulation of eclosion. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Eclosion hormone. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1632960_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Eh. Gene sequence location is 3R:13272364..13274580.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90B1-90B1   Limits computationally determined from genome sequence between P{EP}CG5208EP562&P{EP}DadEP3196 and P{PZ}l(3)0788207882
Experimentally Determined Cytological Location
Cytogenetic map Notes References 90B1-90B2   (determined by in situ hybridisation)   (Horodyski, 1992) 90B1-90B2   (determined by in situ hybridisation)   (Horodyski et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Eh for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Eh-RA FBtr0083444  NM_079662   704   97 Eh-RB FBtr0334930  NM_001275739   700   97
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Eh-PA   FBpp0082885   10.6   97   7.22     NP_524386   AAF55423 Eh-PB   FBpp0306950   10.6   97   7.22     NP_001262668   AGB96048
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Eclosion hormone (IPR006825)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55423   AE014297 AGB96048   BT023233   EL870899   EL870968   X72302 CAA51050   X72303 CAA51051
UniProtKB/Swiss-Prot	Q07892
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic central brain neuron   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{GAL4-Eh.0.8} Stage Tissue/Position (including subcellular localization) Reference embryonic stage 17 -- wandering third instar larval stage   brain | restricted   (McNabb et al., 1997) neuron of brain | subset   (McNabb et al., 1997) neuron | subset   (McNabb et al., 1997) Reporter: P{GAL4-Eh.2.4} Stage Tissue/Position (including subcellular localization) Reference embryonic stage 17 -- wandering third instar larval stage   neuron | subset   (McNabb et al., 1997) brain | restricted   (McNabb et al., 1997) neuron of brain | subset   (McNabb et al., 1997) larval stage -- adult stage   neuron of brain | subset   (Clark et al., 2002) brain | restricted   (Clark et al., 2002) neuron | subset   (Clark et al., 2002) pupal stage   neuron of central nervous system | subset   (Baker et al., 1999) central nervous system | restricted   (Baker et al., 1999) neuron | subset   (Baker et al., 1999)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    168.1 Larval Midgut    3.8 Larval Hindgut    1.1 Larval Malpighian Tubules    1.5 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    1.6 Larval Carcass    1.225 Adult Head    5.9 Adult Eye    2.325 Adult Brain    16.1 Adult Thoracic-Abdominal Ganglion    1.6 Adult Crop    5.4 Adult Midgut    2.8 Adult Hindgut    3.5 Adult Malpighian Tubules    2.2 Adult Fat Body    1.6 Adult Salivary Gland    6.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    2.2 Adult Ovary    1 Adult Testis    1.8 Adult Male Accessory Gland    1.2 Adult Carcass    4.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.9   NA  Eye    2.325   NA  Brain    no informative data   168.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.6   NA  Crop    5.4   3.8  Midgut    2.8   1.1  Hindgut    3.5   1.5  Malpighian Tubules    2.2   3.8  Fat Body    1.6   2.4  Salivary Gland    6.2   NA  Heart    1.425   1.6  Trachea    NA   NA  VirginFemale Spermatheca    1.5   NA  InseminatedFemale Spermatheca    2.2   NA  Ovary    1   NA  Testis    1.8   NA  Male Accessory Gland    1.2   1.225  Carcass    4.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    5 central nervous system, pupae P8    7 head, virgin 1-day female    0 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    98 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (98) white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    98 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    98 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    98 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr  (98) white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    98 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    98 white prepupae 24hr    3 pupae 2d postWPP    3 pupae 3d postWPP    3 pupae 4d postWPP    8 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_12
External Data & Images
Linkouts	BDGP expression data • IP02817 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000564 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5400-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Eh Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Eh Class Mutagen Stocks Known lesion EhGD3938 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes EhJF02143 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{GAL4-Eh.0.8} No P{GAL4-Eh.2.4} No UAS construct P{GD3938} NA P{TRiP.JF02143} NA characterization construct P{Eh-GAL80.2.4} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ecdysis-triggering hormone activity inferred from electronic annotation with InterPro:IPR006825 (FlyBase Curators et al., 2004-) eclosion hormone activity inferred from sequence or structural similarity (Horodyski et al., 1993) inferred from sequence or structural similarity with UniProtKB:P11919 (FlyBase, 1992-) non-traceable author statement (Hewes and Taghert, 2001) neuropeptide hormone activity non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) traceable author statement (vanden Broeck, 2001)
Biological Process
CV term Evidence References
adult behavior non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) ecdysis, chitin-based cuticle inferred from electronic annotation with InterPro:IPR006825 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) eclosion traceable author statement (vanden Broeck, 2001) neuropeptide signaling pathway inferred from electronic annotation with InterPro:IPR006825 (FlyBase Curators et al., 2004-) traceable author statement (vanden Broeck, 2001) regulation of eclosion inferred from sequence or structural similarity (Horodyski et al., 1993)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Eh allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000564
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6575TB Dipteran inclusive ortholog search EOG6N04QG Insect inclusive ortholog search EOG64XHF2 Arthropod inclusive ortholog search EOG6MSBGG Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6575TB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Eh     Drosophila simulans   Dsim\Eh Y   Drosophila sechellia   Dsec\Eh Y   Drosophila erecta   Dere\GG16772 Y   Drosophila yakuba   Dyak\GE25269 Y   Drosophila ananassae   Dana\GF18611 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18853 Y   Drosophila persimilis   Dper\GL23932 Y   Drosophila willistoni   Dwil\GK11451 Y   Drosophila virilis   Dvir\GJ22822 Y   Drosophila mojavensis   Dmoj\GI22821 Y   Drosophila grimshawi   Dgri\GH17491 Y
Orthologs in non-Drosophila Dipterans (EOG6N04QG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011228   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015552   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011229   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006722   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014409   Anopheles gambiae Malaria mosquito  Agam\ECH   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013610   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013611   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011911
Orthologs in non-Dipteran Insects (EOG64XHF2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49648   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003184   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14781   Atta cephalotes Leafcutter ant  Acep\ACEP23937   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11209   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10901   Linepithema humile Argentine ant  Lhum\LH19695   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23232   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007357   Acyrthosiphon pisum Pea aphid  Apim\ACYPI42083   Acyrthosiphon pisum Pea aphid  Apim\ACYPI085492   Bombyx mori Silkmoth  Bmor\BGIBMGA006291   Pediculus humanus Human body louse  Phum\PHUM580410   Tribolium castaneum Red flour beetle  Tcas\Eh
Orthologs in non-Insect Arthropods (EOG6MSBGG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\fru   Ixodes scapularis Deer tick  Isca\ISCW001941
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Eh Drosophila sechellia Dsec\Eh Drosophila erecta Dere\GG16772 Drosophila yakuba Dyak\GE25269 Drosophila ananassae Dana\GF18611 Drosophila pseudoobscura pseudoobscura Dpse\GA18853 Drosophila persimilis Dper\GL23932 Drosophila willistoni Dwil\GK11451 Drosophila virilis Dvir\GJ22822 Drosophila mojavensis Dmoj\GI22821 Drosophila grimshawi Dgri\GH17491
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	26244 y1 v1; P{TRiP.JF02143}attP2
VDRC	v44967 w1118; P{GD3938}v44967/TM3
Genomic Clones ( 1 )
	BACR29H07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP02817
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP03017 IP03117
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000564 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42101
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Isolation and characterisation of Eh. (Horodyski et al., 1993) Eh gene structure and expression has been characterised. (Horodyski et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079662 NM_001275739 RefSeq (Proteins) • NP_524386 NP_001262668 DDBJ / EMBL / GenBank • AAF55423 AGB96048 CAA51050 CAA51051 X72302 X72303 Entrez Gene - A searchable database of RefSeq genes. • 42101 UniProtKB/Swiss-Prot • Q07892
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Eclosion hormone (IPR006825) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP02817
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000564 DRSC - Results from RNAi screens. • FBgn0000564 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000564 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5400-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000564 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42101 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/eclosnh1.htm modMine - Data generated by the modENCODE project. • FBgn0000564
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG5400 (Perkins et al., 2009.3.31) DMEHAB (Colson and Goldstein, 1999, Schug et al., 1998, Schug et al., 1997, Kennington et al., 2006) Drm-EH (vanden Broeck, 2001) EH (Casci, 2004, Clark et al., 2002, McNabb and Truman, 1999, McNabb et al., 1997, McNabb et al., 1997, Baker and Truman, 1997, McNabb et al., 1995, Davis et al., 2007, Park et al., 2008, Davis et al., 2007, Rayburn et al., 2009, Morton et al., 2008, Cherbas et al., 2011, Kim and Marqués, 2010, McNabb and Truman, 2008) eh (Horodyski, 1993.5.27, Horodyski, 1993.5.27, Santos et al., 2007, Melcher and Pankratz, 2005, Bartkuhn et al., 2009) Eh (Gauthier and Hewes, 2006, Coffman et al., 2005, Thomas et al., 2012) EHAB (Colson and Goldstein, 1999)
Name Synonym	Eclosion hormone (Kim et al., 2006, Gauthier and Hewes, 2006) eclosion hormone (Davis et al., 2007, Santos et al., 2007, Park et al., 2008, Davis et al., 2007, Rayburn et al., 2009, Zhou et al., 2009, Veenstra et al., 2008, Kim and Marqués, 2010, McNabb and Truman, 2008)
Secondary FlyBase IDs
	FBgn0026855
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 1 ) Review  ( 5 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 15 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Thomas et al., 2012, PLoS ONE 7(7): e40276 A Versatile Method for Cell-Specific Profiling of Translated mRNAs in Drosophila. [FBrf0218903] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...