General Information
Symbol
Dmel\Eip74EF
Species
D. melanogaster
Name
Ecdysone-induced protein 74EF
Annotation Symbol
CG32180
Feature Type
FlyBase ID
FBgn0000567
Gene Model Status
Stock Availability
Gene Snapshot
Ecdysone-induced protein 74EF (Eip74EF) is a transcription factor that responds to different concentrations of 20-hydroxyecdysone. Eip74EF contributes to puparium formation and autophagy. [Date last reviewed: 2016-09-01]
Also Known As
E74, E74A, E74B, ECIP, Eip74
Genomic Location
Cytogenetic map
Sequence location
3L:17,558,672..17,619,325 [-]
Recombination map
3-45
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the ETS family. (P11536P20105)
Summaries
Gene Group Membership
ETS DOMAIN TRANSCRIPTION FACTORS -
The E26 transformation specific (ETS) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These factors are characterized by a conserved 85 amino acid DNA binding ETS domain that binds specifically to purine-rich DNA motif GGAA/T. (Adapted from PMID:11715049 and PMID:9570133).
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
E74: Ecdysone-inducible gene encoded in region 74 (W.A. Segraves)
Encodes an ecdysone-inducible gene associated with the early puff at 74E-F. Periodic expression of the gene follows, by approximately one hour, pulses of ecdysone occurring during development; two periods of expression occur independently of ecdysone pulses, one at the end of embryogenesis and one at the end of pupal development. Return to base line levels of expression requires protein synthesis and presumably results from repression by ecdysone-induced gene products; in situ hybridization to larvae detects transcription of E74 in most tissues, both imaginal and strictly larval.
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Eip74EF or the JBrowse view of Dmel\Eip74EF for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
gene_with_start_codon_CUG ; SO:0001740
Unconventional translation start (CUG) postulated; FBrf0051390, FBrf0064374.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075202
6012
829
FBtr0075204
5059
883
FBtr0075203
6012
868
FBtr0100411
6239
883
FBtr0305796
6012
844
Additional Transcript Data and Comments
Reported size (kB)
6.0 (northern blot)
6.0, 5.1, 4.8 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074965
87.1
829
6.53
FBpp0074967
94.8
883
6.90
FBpp0074966
91.3
868
6.48
FBpp0099825
94.8
883
6.90
FBpp0297063
88.5
844
6.53
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

883 aa isoforms: Eip74EF-PB, Eip74EF-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
883, 829 (aa); 94.7, 87.1 (kD predicted)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip74EF using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR000418
(assigned by InterPro )
Biological Process (8 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(assigned by GO_Central )
Expression Data
Transcript Expression
dissected tissue
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: Assay specific to Eip74EF transcripts Eip74EF-RA (E74A) and Eip74EF-RB (E74B).

adult head

Comment: Assay specific to Eip74EF transcript Eip74EF-RA (E74A) and Eip74EF-RB (E74B). Only Eip74EF-RA is expressed.

adult head

Comment: Assay specific to Eip74EF transcript Eip74EF-RA (E74A).

Additional Descriptive Data
Expression increases after the late larval (-4 hr APF) and prepupal (+10 hr APF) ecdysone pulses.
Eip74EF transcript Eip74EF-RA is expressed in pupa and adult males. Transcript Eip74EF-RB is absent from adult males.
Eip74EF transcript is strongly expressed in salivary glands at the late larval and late prepupal ecdysone pulses.
RNA blots were carried out on RNA extracted from staged larval and prepupal salivary glands. Eip74EF transcripts are induced in apparent response to the late-larval and prepupal ecdysone pulses paralleling the puffing response at 74EF. This response is enhanced in response to ectopic ftz-f1 expression.
Peaks of Eip74EF expression are seen in late embryos, late third instar larvae, and mid pupae.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult head | intense

Comment: Adults younger than 12h. Assay specific to Eip74EF isoform Eip74EF-PA (E74A).

adult head

Comment: Assay specific to Eip74EF isoform Eip74EF-PA (E74A).

adult head | faint

Comment: Assay specific to Eip74EF isoform Eip74EF-PA (E74A).

Additional Descriptive Data
Eip74EF protein isoform Eip74EF-PA is strongly expressed in the head of adults younger than 12h. Expression decreases rapidly and from day 1 onwards, weak expression is observed.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Eip74EF in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Allele of Eip74EF
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
Transgenic Constructs ( 8 )
Deletions and Duplications ( 8 )
Summary of Phenotypes
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
7 of 13
Yes
Yes
5 of 13
No
Yes
5 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
5 of 12
Yes
Yes
4 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (17)
7 of 15
Yes
Yes
6 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
6 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (2)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907WG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D5Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GED )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GEX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04CD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    RNA-protein
    Interacting group
    Assay
    References
    RNA-RNA
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-45
    Cytogenetic map
    Sequence location
    3L:17,558,672..17,619,325 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    74D4-74E2
    Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    74F1-75A1
    (determined by in situ hybridisation)
    74E-74F
    (determined by in situ hybridisation)
    74F-74F
    (determined by in situ hybridisation)
    74F-75A
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (37)
    Genomic Clones (37)
    cDNA Clones (42)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: Eip74EF CG6273
    Additional comments
    Annotations CG6273 and CG6285 merged as CG32180 in release 3 of the genome annotation.
    Other Comments
    Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.
    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Eip74EF appears to regulate the timing of hormone-induced cell responses.
    Eip74EF is required for salivary gland, autophagic, cell death.
    Eip74EF isoforms can positively regulate one another. Ectopic expression of Eip74EF can partially repress Hr46 and Eip78C and efficiently repress Eip4F and the late L71 genes. Eip74EFA is both necessary and sufficient for Eip78CB induction, supporting a key role for Eip74EFA in Eip78CB expression. Ectopic Eip74EFA is sufficient to induce only low levels of transcription in some later genes, even in an Eip74EFB mutant background. The ecdysone-triggered isoform switch from an Eip74EFB repressor to an Eip74EFA inducer is necessary, but not sufficient, for the proper timing of late gene induction at puparium formation.
    Eip74EF is one of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.
    Reduced dosage of the early puff genes Eip74EF and Eip75B reduces the size of the late puffs and increasing the dosage increases the sizes.
    Analysis of morphological and molecular phenotypes of double mutants between alleles of br and Eip74EF reveals that br and Eip74EF share functions in puparium formation, pupation and early gene induction.
    The br and Eip74EF transcription factors may directly interact to regulate the expression of salivary gland glue and late genes.
    Loss of function mutations of Eip74EF have been used to study the the roles of E74A and E74B proteins during metamorphosis and their roles in salivary gland polytene chromosome puffing hierarchy.
    Four strong Eip74EF binding sites lie within the shared regulatory sequences of Eig71Ef and Eig71Eg. Results from Ecol\lacZ reporter gene constructs demonstrate these sites are required for the proper timing of Eig71Eg induction.
    Comparison of the nucleotide sequence of the 5' leader sequences from Eip74EF, Dpse\Eip74EF and Dvir\Eip74EF has identified 3 exons that specify the leader sequence and identification and characterisation of elements important in controlling expression.
    Eip74EF is one of the sites of chromosomal binding of Trl protein.
    Ecdysteroid-regulated gene.
    DNA transfections into Drosophila culture cells have been used to define regions of the Eip74EF mRNA required for proper translation initiation. Translation of the Eip74EF protein uses at least three initiator codons: two minor codons (AUG and CUG) and one major CUG codon. Features such as RNA secondary and tertiary structures may play a role in initiator codon selection.
    The function of br is required for the complete ecdysone induction of early mRNAs from Eip74EF, Eip75B and the broad complex itself.
    The sequential-temporal expression of steroid hormone-responsive genes in imaginal discs may be important in organizing cellular mechanisms involved in morphogenesis of the epithelium.
    The developmentally regulated peak of arginine kinase at pupal stage P3 is affected by altering the copy number of Eip75B and BRC, but not Eip74EF.
    An ecdysone-inducible gene associated with the early puff at 74E-F.
    Periodic expression of the gene follows, by approximately one hour, pulses of ecdysone occurring during development; two periods of expression occur independently of ecdysone pulses, one at the end of embryogenesis and one at the end of pupal development. Return to base line levels of expression requires protein synthesis and presumably results from repression by ecdysone-induced gene products; in situ hybridisation to larvae detects transcription of E74 in most tissues, both imaginal and strictly larval.
    Comparison of Dpse\Eip74EF, Dvir\Eip74EF and Eip74EF shows that several characteristics of the gene have been conserved between the species, including ecdysone inducibility, localisation to ecdysone-induced polytene chromosome puffs, and gene size.
    Splicing of the Eip74EF E74A transcript occurs before polyadenylation.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 85 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Linkouts
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Synonyms and Secondary IDs (30)
    Reported As
    Symbol Synonym
    E74
    (Lee et al., 2018, Ables and Drummond-Barbosa, 2017, Yun et al., 2017, Sengupta et al., 2016, Wang et al., 2016, Zheng et al., 2016, Lengil et al., 2015, Xie et al., 2015, Bernardo et al., 2014, Claudius et al., 2014, Kim et al., 2014, Liu et al., 2014, Deng and Kerppola, 2013, Hill et al., 2013, Hyun, 2013, Chauhan et al., 2012, Jin et al., 2012, Liu et al., 2012, Ou et al., 2011, Dialynas et al., 2010, Fraichard et al., 2010, Francis et al., 2010, Rendina et al., 2010, Ritter and Beckstead, 2010, Bernardo et al., 2009, Kozlova et al., 2009, Chen et al., 2008, Costantino et al., 2008, Lecci et al., 2008, Wang et al., 2008, Bashirullah et al., 2007, Huang et al., 2007, Martin et al., 2007, McBrayer et al., 2007, Varghese and Cohen, 2007, Basso et al., 2006, Kanao and Miyachi, 2006, King-Jones et al., 2005, Kon et al., 2005, Lim et al., 2004, McCall, 2004, Westwood et al., 2004, Kumar et al., 2003, Li and White, 2003, Yamazaki et al., 2003, Lee et al., 2002, Pokholkova and Zhimulev, 2002, Thummel and Chory, 2002, Gu et al., 2001, Lee et al., 2001, Thummel, 2001, Venkatesh et al., 2001, Baehrecke, 2000, Hsu and Schulz, 2000, Kas et al., 2000, Kozlova and Thummel, 2000, Lafont, 2000, Lee and Baehrecke, 2000, Lee et al., 2000, Lee et al., 2000, Lee et al., 2000, Pecasse et al., 2000, Reid et al., 2000, Baehrecke and Lee, 1999, Buszczak et al., 1999, Lam et al., 1999, Oettgen et al., 1999, Pastorcic and Das, 1999, Reid et al., 1999, Thummel et al., 1999, Baehrecke and Lee, 1998, Buszczak et al., 1998, D'Avino and Thummel, 1998, Hall and Thummel, 1998, Halsell and Kiehart, 1998, Mo et al., 1998, Reid and Thummel, 1998, Bender et al., 1997, Dhulipal, 1997, Drosopoulou et al., 1997, Dubrovsky and Berger, 1997, Fletcher et al., 1997, Lam et al., 1997, Wilkins and Lis, 1997, Baehrecke, 1996, Bayer et al., 1996, Burke and Kadonaga, 1996, Lehmann, 1996, Segarra et al., 1996, Bender, 1995, Fletcher and Thummel, 1995, Fletcher et al., 1995, Granok et al., 1995, Huet et al., 1995, Andrew and Scott, 1994, Atkinson, 1994, Jindra, 1994, Tsukiyama et al., 1994, Fristrom and Fristrom, 1993, Natzle, 1993, Soeller et al., 1993, Truman et al., 1993, Andres and Thummel, 1992, Arkhipova and Ilyin, 1992, Chen et al., 1992, Oro et al., 1992, Read and Manley, 1992, Thummel, 1992, Arkhipova and Ilyin, 1991, Jarrell and Meselson, 1991, Karim and Thummel, 1991, Ashburner, 1990, Thummel, 1990, Thummel et al., 1990, Urness and Thummel, 1990, Thummel, 1989)
    E74A
    (Kang et al., 2017, Zheng et al., 2017, Valzania et al., 2016, Nicolson et al., 2015, Yan et al., 2015, Gündner et al., 2014, Ihry and Bashirullah, 2014, Mulakkal et al., 2014, Neuman et al., 2014, Chauhan et al., 2013, Denton et al., 2013, Morozov and Ioshikhes, 2013, Anhezini et al., 2012, Ihry et al., 2012, Akagi and Ueda, 2011, Ou et al., 2011, Walker et al., 2011, Capelson et al., 2010, Ruaud et al., 2010, van der Knaap et al., 2010, Wang et al., 2010, Chen et al., 2008, Beckstead et al., 2007, Cao et al., 2007, Huang et al., 2007, McBrayer et al., 2007, Thummel, 2007, Yoshikane et al., 2007, Caldwell et al., 2006, Ciurciu et al., 2006, Kraft et al., 2006, Sun and Song, 2006, Wegman et al., 2006, Beckstead et al., 2005, Caldwell et al., 2005, Kilpatrick et al., 2005, Kumar and Cakouros, 2004, Martin and Baehrecke, 2004, Bashirullah et al., 2003, Daish et al., 2003, Basso et al., 2002, Bialecki et al., 2002, Lee et al., 2002, Lee et al., 2002, Lee et al., 2002, Lehmann et al., 2002, Pile et al., 2002, Beckstead et al., 2001, Biyasheva et al., 2001, Gibson and Schubiger, 2001, Lee and Baehrecke, 2001, Lee et al., 2001, Simon et al., 2001, Thummel, 2001, Hock et al., 2000, Jiang et al., 2000, Kutach and Kadonaga, 2000, Lafont, 2000, Li and Bender, 2000, Broadus et al., 1999, Burden and Osheroff, 1999, Richards et al., 1999, Burke et al., 1998, Buszczak and Segraves, 1998, Fisk and Thummel, 1998, Lam et al., 1997, Thummel, 1997, Venkatesh and Hasan, 1997, White et al., 1997, Huet et al., 1996, Meister and Richards, 1996, Baehrecke and Thummel, 1995, D'Avino et al., 1995, Henrich and Brown, 1995, Urness and Thummel, 1995, Jones et al., 1994, Woodard et al., 1994, Andres et al., 1993, Bornschein et al., 1993, Boyd and Thummel, 1993, Karim et al., 1993, Riddiford, 1993, Wasylyk et al., 1993, Chen et al., 1992, Karim and Thummel, 1992, Boyd et al., 1991, Burtis et al., 1990, le Maire and Thummel, 1990)
    l(3)24
    l(3)neo24
    Name Synonyms
    Ecdysone-induced prot 74EF
    Ecdysone-induced-protein 74EF
    ecdysone induced protein 74EF
    ecdysone inducible protein
    ecdysone-induced protein 74EF
    Secondary FlyBase IDs
    • FBgn0011459
    • FBgn0026806
    • FBgn0036739
    • FBgn0052180
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (354)