E75, E75A, E75B, E75C, Eip75
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 6.02
6, 5.7, 5.2, 4.9 (northern blot)
1394, 1237 (aa); 151, 132 (kD predicted)
One of a couple of protein products.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip75B using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Eip75B in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutations affecting isoform A cause a reduced ecdysteroid titer during larval development, resulting in developmental delays, developmental arrests, and molting defects. These defects are rescuable by ecdysone treatment.
Ecdysteroid-induced Eip75B expression amplifies or maintains ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle.
Hr46 receptor represses the early genes activated by the late-larval ecdysone pulse and with the help of Eip75B, provides a temporal linkage between the two ecdysone responses by controlling the expression of ftz-f1.
One of a class of genes with TATA-less promoters that have a subset of the conserved DPE sequence.
A fragment of a Eip75B cDNA has been used to clone a homologous gene from the wax moth Galleria mellonella.
Eip75B protein binds to discrete sites on polytene chromosomes, correlating with early and late ecdysone-induced puffs.
Random cDNAs from subtracted libraries subjected to a rapid and sensitive screen for their ability to detect mRNAs induced by ecdysone in the presence of cycloheximide identified the ecdysone inducible gene Eip75B.
Encodes an ecdysone-inducible gene associated with the early puff at polytene position 75B. Periodic expression occurs in response to ecdysone pulses occurring at specific times during development; regression of puff and reduction of Eip75B expression in third instar does not occur in the presence of cycloheximide, and presumably depends on ecdysone-induced gene products.