Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\E(SD) using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\E(SD) in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
All naturally occurring SD chromosomes carry RanGapSD and Rspi. Typical SD+ chromosomes carry Rsps and its presence is sufficient to render a chromosome sensitive to the action of RanGapSD. Some SD+ chromosomes carry Rspi. To cause high levels of distortion, RanGapSD requires the presence of a series of upward modifiers known as E(SD)unspecified, St-SDunspecified and M(Sd)unspecified.
E(SD)unspecified is required for full meiotic drive and can augment the action of RanGapSD when supplied in trans from the Y or second chromosome. Significant RanGapSD-caused segregation distortion is observed with 2 doses of E(SD)unspecified, even in the absence of RanGap+. E(SD)unspecified enhances distortion in a dose-dependent manner. E(SD)unspecified distortion is mediated via Rsp, whether Rsp is on the Y or second chromosome and can be suppressed by an unlinked dominant suppressor of SD action. E(SD)unspecified is independently capable of acting on Rsp and is not a simple modifier of RanGapSD.
Deletion analysis of SD chromosomes demonstrates that E(SD)unspecified is common to all SD chromosomes, the E(SD)unspecified allele on each SD chromosome enhances distortion by the same amount, E(SD)unspecified acts in a dosage-dependent manner and causes little or no distortion in the absence of RanGapSD. E(SD)unspecified exerts its effect in cis or trans to RanGapSD.