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Gene Dmel\Est-P

General Information
Symbol	Dmel\Est-P	Species	D. melanogaster
Name	Esterase P	Annotation symbol	CG17148
Feature type	protein_coding_gene	FlyBase ID	FBgn0000594
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	yEst-6, ΨEst-6, ESTP, Est-7, EST-5
Genomic Location
Chromosome (arm)	3L	Recombination map	3-35.9
Cytogenetic map	69A1-69A1	Sequence location	3L:12,183,833..12,185,628 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Esterase P is referred to in FlyBase by the symbol Dmel\Est-P (CG17148, FBgn0000594). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: carboxylesterase activity. The biological processes in which it is involved are not known. 33 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Carboxylesterase type B, active site; Carboxylesterase type B, conserved site; Carboxylesterase, type B. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637674_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Est-P. Gene sequence location is 3L:12183833..12185628.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69A1-69A1   Limits computationally determined from genome sequence between P{PZ}rols08232&P{lacW}l(3)j2D3j2D3 and P{PZ}l(3)0508805088
Experimentally Determined Cytological Location
Cytogenetic map Notes References 69A-69A   (determined by in situ hybridisation)   (Segarra et al., 1996) 69A1-69A1   (determined by in situ hybridisation)   (Oakeshott et al., 1993)
Experimentally Determined Recombination Data
Location	3-35.9
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Est-P for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Est-P-RA FBtr0076004  NM_176323   1740   544
Additional Transcript Data & Comments
Reported size (kB)	1.92, 1.25 (northern blot) (Collet et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Est-P-PA   FBpp0075736   61.1   544   6.79     NP_788501   AAF49945
Additional Polypeptide Data & Comments
Reported size (kDa)	544 (aa) (Collet et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Carboxylesterase, type B (IPR002018) Carboxylesterase type B, conserved site (IPR019819) Carboxylesterase type B, active site (IPR019826)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49945   AF150809   AF150810   AF150811   AF150812   AF150813   AF150814   AF150815   AF526538   AF526539   AF526540   AF526541   AF526542   AF526543   AF526544   AF526545   AF526546   AF526547   AF526548   AF526549   AF526550   AF526551   AF526552   AF526553   AF526554   AF526555   AF526556   AF526557   AF526558   AF526559   AY247987   AY247988   AY247989   AY247990   AY247991   AY247992   AY247993   AY247994   AY247995   AY247996   AY247997   AY247998   AY247999   AY248000   AY248001   AY248002   AY248003   AY248004   AY248005   AY248006   AY248007   AY248008   AY248009   AY248010   AY248011   AY248012   AY248013   AY248014   AY248015   AY248016   AY248017   AY248018   AY248019   AY248020   AY248021   AY248022   AY248023   AY248024   AY248025   AY248026   AY248027   AY248028   AY248029   AY248030   AY248031   AY248032   AY248033   AY248034   AY248035   AY248036   BT023943   M33780 AAA28520
UniProtKB/Swiss-Prot	P18167
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference larval stage | late     (Collet et al., 1990) adult stage     (Collet et al., 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass    676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass  (676.05) Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass    676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass    676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass    676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass  676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass    676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.8 Larval Midgut    1.7 Larval Hindgut    33.2 Larval Malpighian Tubules    23.7 Larval Fat Body    4.5 Larval Salivary Gland    8.9 Larval Trachea    85.875 Larval Carcass    676.05 Adult Head    6.3 Adult Eye    4.35 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    5 Adult Midgut    4.2 Adult Hindgut    3.4 Adult Malpighian Tubules    4.7 Adult Fat Body    8 Adult Salivary Gland    42.3 Adult Heart    6.1 Adult VirginFemale Spermatheca    14.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    1.3 Adult Testis    4.1 Adult Male Accessory Gland    6.8 Adult Carcass    7.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    6.3   NA  Eye    4.35   NA  Brain    1.9   2.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.1   NA  Crop    5   1.7  Midgut    4.2   33.2  Hindgut    3.4   23.7  Malpighian Tubules    4.7   4.5  Fat Body    8   8.9  Salivary Gland    42.3   NA  Heart    6.1   85.875  Trachea    NA   NA  VirginFemale Spermatheca    14.3   NA  InseminatedFemale Spermatheca    8.6   NA  Ovary    1.3   NA  Testis    4.1   NA  Male Accessory Gland    6.8   676.05  Carcass    7.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    56 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering  (56) carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    56 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    56 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    56 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering  (56) carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    56 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    56 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    83 white prepupae new    37 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6  (41) larva L3 puffstage 7-9  (83) white prepupae new  (37) white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    83 white prepupae new    37 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    83 white prepupae new    37 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    83 white prepupae new    37 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6  (41) larva L3 puffstage 7-9  (83) white prepupae new  (37) white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    83 white prepupae new    37 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    41 larva L3 puffstage 7-9    83 white prepupae new    37 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3  (44) Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3  (44) Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000594 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17148-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | adult stage, with Scer\GAL4pnr-MD237 Est-PGD6547 viable Est-P357F Est-P510S Other Phenotypes Allele electrophoretic variant | fast Est-P357F Est-P521F Est-PF-96S Est-PF-274F Est-PF-517F Est-PF-517S Est-PF-531F Est-PF-611F Est-PF-775F Est-PF-1461S electrophoretic variant | slow Est-P94F Est-P174F Est-P255S Est-P377F Est-P510S Est-P521F Est-P521S Est-P581F Est-P968F Est-PS-5F Est-PS-26F Est-PS-114S Est-PS-438S Est-PS-483F Est-PS-501S Est-PS-549S Est-PS-565F Est-PS-1224F Est-PUS-255F Phenotype manifest in Allele
Classical Alleles ( 28 )
For All Classical Alleles Show
Allele of Est-P Class Mutagen Stocks Known lesion Est-P174F natural population 0 Yes Est-P255S natural population 0 Yes Est-P357F natural population 0 Yes Est-P377F natural population 0 -- Est-P510S natural population 0 Yes Est-P521F natural population 0 Yes Est-P521S natural population 0 Yes Est-P581F natural population 0 -- Est-P94F natural population 0 Yes Est-P968F natural population 0 Yes Est-PF-1461S natural population 0 Yes Est-PF-274F natural population 0 Yes Est-PF-517F natural population 0 Yes Est-PF-517S natural population 0 Yes Est-PF-531F natural population 0 Yes Est-PF-611F natural population 0 Yes Est-PF-775F natural population 0 -- Est-PF-96S natural population 0 Yes Est-PS-114S natural population 0 Yes Est-PS-1224F natural population 0 Yes Est-PS-26F natural population 0 Yes Est-PS-438S natural population 0 -- Est-PS-483F natural population 0 Yes Est-PS-501S natural population 0 Yes Est-PS-549S natural population 0 Yes Est-PS-565F natural population 0 Yes Est-PS-5F natural population 0 Yes Est-PUS-255F natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Est-P Class Mutagen Stocks Known lesion Est-PGD6547 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Est-P-1174.+2731 in vitro construct - deletion 0 Yes Est-P-1174.+4174 in vitro construct 0 Yes Est-P-24.+4252 in vitro construct 0 Yes Est-PNIG.17148R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6116 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6547} NA P{NIG.17148R} NA characterization construct P{Est-6.-24/+4252} NA P{Est-6.-1174/+2731} NA P{Est-6.-1174/+4174} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
carboxylesterase activity inferred from biological aspect of ancestor with PANTHER:PTN000168392 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with UniProtKB:P18167 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Est-P allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000594 DroID - A comprehensive database of gene and protein interactions. • FBgn0000594
Orthologs
OrthoDB Orthologs (69) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG602XBR Dipteran inclusive ortholog search EOG60K874 Insect inclusive ortholog search EOG6G79TS, EOG6BK3ZZ Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG65J4QT
Orthologs in Drosophila Species (EOG602XBR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Est-P     Drosophila melanogaster fruit fly  Dmel\Est-6     Drosophila simulans   Dsim\Est-P Y Y Drosophila simulans   Dsim\Est-6   Y Drosophila sechellia   Dsec\Est-P Y Y Drosophila sechellia   Dsec\Est-6   Y Drosophila erecta   Dere\Est-P Y Y Drosophila erecta   Dere\Est-6   Y Drosophila yakuba   Dyak\Est-7 Y Y Drosophila yakuba   Dyak\GE21892   Y Drosophila ananassae   Dana\GF24810   Y Drosophila pseudoobscura pseudoobscura   Dpse\Est-5C   Y Drosophila pseudoobscura pseudoobscura   Dpse\Est-5B   Y Drosophila persimilis   Dper\Est-5A Y Y Drosophila persimilis   Dper\Est-5C   Y Drosophila persimilis   Dper\Est-5B   Y Drosophila willistoni   Dwil\GK25474   Y Drosophila virilis   Dvir\GJ10073   Y Drosophila virilis   Dvir\GJ10074   Y Drosophila virilis   Dvir\GJ10075   Y Drosophila mojavensis   Dmoj\GI22473   Y Drosophila mojavensis   Dmoj\GI22474   Y Drosophila mojavensis   Dmoj\GI22476   Y Drosophila grimshawi   Dgri\GH15533   Y
Orthologs in non-Drosophila Dipterans (EOG60K874)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012509 Y Anopheles gambiae Malaria mosquito  Agam\COEBE4D Y Anopheles gambiae Malaria mosquito  Agam\COEBE3D Y Anopheles gambiae Malaria mosquito  Agam\COEBE1D Y Anopheles gambiae Malaria mosquito  Agam\COEBE2D Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006908 Y
Orthologs in non-Dipteran Insects (EOG6G79TS, EOG6BK3ZZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017690 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018226 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017543 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016181 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006836 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007567 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG017702 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018223 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14024 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14025 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14023 Y Tribolium castaneum Red flour beetle  Tcas\TC011395 Y Tribolium castaneum Red flour beetle  Tcas\Est-6 Y Tribolium castaneum Red flour beetle  Tcas\TC011376 Y Tribolium castaneum Red flour beetle  Tcas\TC011396 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG65J4QT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K07C11.4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004183gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000518gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002973gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021033gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011237gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026312gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004761gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001298gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002970gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000153gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000154gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000155gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000150gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004182gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004181gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014912gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008473gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028072gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002971gn Y Mus musculus House mouse  Mmus\Ces4a Y Mus musculus House mouse  Mmus\Ces1g Y Rattus norvegicus Norway rat  Rnor\Ces4a Y Homo sapiens Human  Hsap\CES4A Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\CES4A
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Est-P Drosophila sechellia Dsec\Est-P Drosophila erecta Dere\Est-P Drosophila yakuba Dyak\Est-7 Drosophila persimilis Dper\Est-5A
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v30870 w1118; P{GD6547}v30870 v30868 w1118; P{GD6547}v30868/CyO
Genomic Clones ( 2 )
	BACR14K14 BACR48J05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP12708
Other clones	DPiM_LP12708
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000594 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39393
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Est-P CG17148 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The more recently acquired site of Est-6 activity, the anterior ejaculatory duct, is directed by distal sequences lying both 5' and 3' of the coding region. The 3' sequences appear to lie within the transcription unit of the adjacent Est-P gene. (Healy et al., 1996) Chromosome homologies of Muller's element D (J chromosome in the Paleartic species and XR chromosome arm in Nearctic species) and of element E (O chromosome in the Paleartic species and 2 chromosome in Nearctic species) have been confirmed by single copy probes in the species of the obscura group and in D.melanogaster. (Segarra et al., 1996) The sequences of the Dpse\Est-5A, Dpse\Est-5B and Dpse\Est-5C genes, and the D.melanogaster Est-6 and Est-P genes have been compared. (Brady and Richmond, 1992) The Est-6 and Est-P genes, which are arranged as a tandem repeat, have been cloned and sequenced. (Collet et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176323 RefSeq (Proteins) • NP_788501 DDBJ / EMBL / GenBank • AAA28520 AAF49945 AF150809 AF150810 AF150811 AF150812 AF150813 AF150814 AF150815 AF526538 AF526539 AF526540 AF526541 AF526542 AF526543 AF526544 AF526545 AF526546 AF526547 AF526548 AF526549 AF526550 AF526551 AF526552 AF526553 AF526554 AF526555 AF526556 AF526557 AF526558 AF526559 AY247987 AY247988 AY247989 AY247990 AY247991 AY247992 AY247993 AY247994 AY247995 AY247996 AY247997 AY247998 AY247999 AY248000 AY248001 AY248002 AY248003 AY248004 AY248005 AY248006 AY248007 AY248008 AY248009 AY248010 AY248011 AY248012 AY248013 AY248014 AY248015 AY248016 AY248017 AY248018 AY248019 AY248020 AY248021 AY248022 AY248023 AY248024 AY248025 AY248026 AY248027 AY248028 AY248029 AY248030 AY248031 AY248032 AY248033 AY248034 AY248035 AY248036 M33780 Entrez Gene - A searchable database of RefSeq genes. • 39393 UniProtKB/Swiss-Prot • P18167
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Carboxylesterase, type B (IPR002018) Carboxylesterase type B, conserved site (IPR019819) Carboxylesterase type B, active site (IPR019826)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000594 DroID - A comprehensive database of gene and protein interactions. • FBgn0000594 DRSC - Results from RNAi screens. • FBgn0000594 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000594 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17148-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000594 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39393 modMine - Data generated by the modENCODE project. • FBgn0000594
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG17148   EST-5 (Bondinas et al., 2001) Est-5 (Segarra et al., 1996) Est-7 (Balakirev and Ayala, 2003, Balakirev et al., 2005) Est7 (Robin et al., 2009) ESTP (Oakeshott et al., 1993) EstP (Game and Oakeshott, 1990, Robin et al., 2009, Dumancic et al., 1997) est-P (Pen et al., 1990) Est-P (Balakirev et al., 2005, Bochdanovits and de Jong, 2004, Weake et al., 2008, Yi et al., 2008, Japanese National Institute of Genetics, 2012.5.21) yEst-6 (Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5) yEst6 (Morrell et al., 2006) ΨEst-6 (Balakirev and Ayala, 2003, Balakirev et al., 2003, Balakirev et al., 1999) ψEst-6 (Balakirev et al., 2005, Balakirev and Ayala, 2003, Balakirev et al., 2006)
Name Synonym	Esterase P
Secondary FlyBase IDs
	FBgn0017620
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 2 ) Review  ( 2 ) Personal communication to FlyBase  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 29 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
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