FlyBase Gene Report: Dmel\eve

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

(Schroeder et al., 2011)

embryonic stage 5 -- 7

(Nasiadka and Krause, 1999)

embryonic stage 7 -- 8

dorsal ectoderm

(Fisher et al., 2012)

ganglion mother cell GMC4-2a

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | posterior

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11

(Bhat, 2014)

embryonic stage 11 -- 12

anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)

cardiogenic mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

RP2sib neuron

(Bhat, 2014)

embryonic stage 11 -- 16

(Bhat, 2014)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

ganglion mother cell | segmentally repeated

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 17

(MacDonald et al., 1986)

embryonic stage 3

organism | 20-70% egg length

(MacDonald et al., 1986)

embryonic stage 4 -- 12

parasegment 1 & parasegment 3 & parasegment 5 & parasegment 7 & parasegment 9 & parasegment 11 & parasegment 13

(MacDonald et al., 1986)

embryonic stage 13 -- 17

parasegment 1 -- parasegment 14

(MacDonald et al., 1986)

(MacDonald et al., 1986)

larval stage

(MacDonald et al., 1986)

Additional Descriptive Data

Comparison of the timing and pattern of eve transcript and protein expression in embryos shows that eve protein is expressed in the same pattern as the RNA with a quanitfied time delay. eve stripe 7 has an increased level of eve RNA relative to protein in early/mid cycle 14A. The difference in maximum amplitude between stripe 3 and stripe 7 is more prounounced at the protein level than at the RNA level.

(Surkova et al., 2019)

After division of the ganglion mother cell GMC4-2a, both daughter cells are eve-positive, but as development proceeds, the RP2sib neuron (sibling cell to RP2 motor neuron) becomes eve-negative, whereas RP2 retains eve.

(Bhat, 2014)

Expression was examined at four phases of embryonic stage 5. The striped pattern becomes visible in phase 1 (0-5'), all stripes except stripe 7 are expressed during phase 2 (5-17'), and their spacing and expression levels become largely uniform by phase 3 (17-30'). The stripes initially appear less clearly separated and more graded.

(Schroeder et al., 2011)

Ectopic eve expression is incapable of activating eve expression outside of its normal domain and causes a premature loss of transcripts within its normal domains of expression.

(Manoukian and Krause, 1992)

eve transcripts are first detected in stage 3 embryos, and displays a low level of expression throughout the embryo. The expression pattern is refined over the next four hours of development. eve expression exhibits a pair-rule pattern, and is expressed in a graded fashion, both along the anterior-posterior axis and the dorsal-ventral axis, with the highest levels of transcript being present in the dorsal-posterior regions. eve is expressed in odd-numbered parasegments in seven stripes, but later in development is expressed coincidently with en, in the posterior section of each parasegment. In the later stages of embryonic development, following germ band retraction, eve transcripts are detected in the neurogenic region in the ganglion mother cells of each segment.

(MacDonald et al., 1986)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

pericardial cell primordium

cardioblast

(Bodmer, 1993)

embryonic stage 8 -- 12

parasegment 1 -- parasegment 14

(Frasch et al., 1987, MacDonald et al., 1986)

embryonic stage 13 -- 17

neurogenic region

(Frasch et al., 1987, MacDonald et al., 1986)

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

cardiogenic mesoderm

(Tögel et al., 2008)

embryonic stage 10 -- 13

(Tögel et al., 2008)

embryonic stage 14 -- 15

Comment: precursor

(Tögel et al., 2008)

embryonic stage 14 -- 17

scutellar pulsatile organ

(Tögel et al., 2008)

embryonic stage 16 -- 17

Comment: precursor

(Tögel et al., 2008)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

neuroblast NB1-2

(Lacin and Truman, 2016)

neuroblast NB4-2

(Lacin and Truman, 2016)

neuroblast NB7-1

(Lacin and Truman, 2016)

embryonic stage 3 -- 11

parasegment 1 & parasegment 3 & parasegment 5 & parasegment 7 & parasegment 9 & parasegment 11 & parasegment 13

(Frasch et al., 1987, MacDonald et al., 1986)

blastoderm stage

(Kania et al., 1990)

embryonic stage 4 -- 5

(Manu et al., 2013, Kellerman et al., 1990)

organism | odd pair rule expression pattern

• nucleus

(Small et al., 1991)

embryonic cycle 14

(Janssens et al., 2013)

embryonic cycle 14A

embryonic pericardial cell

• nucleus

(Gursky et al., 2001)

embryonic stage 9

neuroblast NB1-1

(Weiss et al., 1998)

neuroblast NB7-1

(Weiss et al., 1998)

midline primordium

Comment: row G in every other segment

(Wheeler et al., 2006)

embryonic stage 10

(Lee and Frasch, 2000)

pericardial cell primordium

(Mirzoyan and Pandur, 2013)

embryonic somatic muscle | dorsal

(Mirzoyan and Pandur, 2013)

embryonic stage 10 -- 11

(Alonso et al., 2001)

(Alonso et al., 2001)

ganglion mother cell GMC4-2a

(Alonso et al., 2001)

cell | subset of mesoderm | dorsal of parasegment 2 -- parasegment 12

Comment: small cluster of dorsal mesoderm cells in parasegments 2-12 and 14

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 2

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 3

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 4

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 5

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 6

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 7

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 8

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 9

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 10

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 11

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 12

(Lawrence et al., 1995)

cell | subset of mesoderm | dorsal of parasegment 14

(Lawrence et al., 1995)

embryonic stage 11

embryonic myoblast

(Han et al., 2002)

cardioblast

(Crackower et al., 2002)

(Bhat, 2014)

embryonic stage 11 -- 12

embryonic heart cardioblast

(Belenkaya et al., 2002)

(Belenkaya et al., 2002)

ganglion mother cell GMC4-2a

Comment: ~6-8 hr AEL

(Yedvobnick et al., 2004)

embryonic stage 12

proctodeum | presumptive

(Frasch et al., 1987, MacDonald et al., 1986)

(Bhat and Apsel, 2004)

A1-7 dorsal acute muscle 1 | precursor

(Bhat and Apsel, 2004)

fpCC neuron

(Bhat and Apsel, 2004)

embryonic stage 12 -- 13

embryonic myoblast

(Yarnitzky et al., 1998)

(Yarnitzky et al., 1998)

mesothoracic dorsal acute muscle 1 | precursor

(Yarnitzky et al., 1998)

metathoracic dorsal acute muscle 1 | precursor

(Yarnitzky et al., 1998)

RP2sib neuron

Comment: ~8.5-10 hr AEL

(Yedvobnick et al., 2004)

embryonic stage 12 -- 15

(Bhat and Apsel, 2004)

RP2sib neuron

(Bhat and Apsel, 2004)

embryonic stage 12 -- 16

embryonic pericardial cell | subset

Comment: ~8.5-14 hr AEL

(Yedvobnick et al., 2004)

embryonic stage 13

(Han and Bodmer, 2003)

A1-7 dorsal acute muscle 1

(Han and Bodmer, 2003)

embryonic stage 13 -- 15

embryonic pericardial cell

(Arquier et al., 2001)

embryonic myoblast | dorsal | subset

(Arquier et al., 2001)

dorsal acute muscle 1 | precursor

• nucleus

(Shelton et al., 2009)

embryonic pericardial cell | subset

• nucleus

(Shelton et al., 2009)

embryonic stage 16

(Bossing et al., 1996)

(Bossing et al., 1996)

(Odden et al., 2002, Bossing et al., 1996)

A1-7 DA1 motor neuron

Comment: aCC motor neuron

(Odden et al., 2002)

A1-7 DO1 motor neuron

Comment: U1 motor neuron

(Odden et al., 2002)

A1-7 DA2 motor neuron

Comment: U2 motor neuron

(Odden et al., 2002)

A1-7 DO2 motor neuron

Comment: U3 motor neuron

(Odden et al., 2002)

A1-7 DA3 motor neuron

Comment: U4 motor neuron

(Odden et al., 2002)

A1-7 LL1 motor neuron

Comment: U5 motor neuron

(Odden et al., 2002)

A1-7 dorsal motor neuron

Comment: RP2 motor neuron

(Odden et al., 2002)

(Odden et al., 2002)

U1 neuron

(Touma et al., 2012)

U2 neuron

(Touma et al., 2012)

U3 neuron

(Touma et al., 2012)

U4 neuron

(Touma et al., 2012)

U5 neuron

(Touma et al., 2012)

(Massarwa et al., 2007)

(Massarwa et al., 2007)

(Bossing et al., 1996)

(Bossing et al., 1996)

first instar larval stage

(Bossing et al., 1996)

larval stage

neuroblast NB7-2

(Lacin and Truman, 2016)

embryonic/larval motor neuron | subset

(Heckscher et al., 2015)

(Heckscher et al., 2015)

cholinergic neuron | subset of larval abdominal segment 1 -- larval abdominal segment 4

(Heckscher et al., 2015)

GABAergic neuron | subset of larval abdominal segment 1 -- larval abdominal segment 4

(Heckscher et al., 2015)

third instar larval stage

(Das et al., 2008)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

(Schafer et al., 2007)

inferred from author statements

Stage

Tissue/Position (including subcellular localization)

Reference

U neuron

(Mellerick and Modica, 2002)

embryonic stage 16 -- second instar larval stage

(Mellerick and Modica, 2002)

Additional Descriptive Data

(Surkova et al., 2019)

eve colocalises with the cholinergic markers Scer\GAL4^ChAT.7.4 and, in a strain also expressing Scer\GAL4^EL.eveRC, cha in nearly all EL neurons. It also colocalizes with GABA, in a strain coexpressing Scer\GAL4^EL.eveRC, in ~25% of EL neurons in larval abdominal segment 1, ~50% in segment 2, and 70-75% in segments 3 and 4.

(Heckscher et al., 2015)

eve stripes 2, 3, and 4 show sexually dimorphic expression.

(Manu et al., 2013)

eve protein is expressed in the DA1 muscle and two pericardial cells per hemisegment in embyros.

(Shelton et al., 2009)

eve is expressed in two pericardial cell nuclei and in 10-11 nuclei of the dorsal acute muscle 1 in each segment.

(Massarwa et al., 2007)

eve is expressed in two Eve pericadial cells (EPC) and one DA1 muscle per hemisegment in stage 13 embryos.

(Han and Bodmer, 2003)

eve is expressed in a segmentally repeated subset of heart precursor cells starting shortly after tin expression is observed in these cells.

(Bodmer, 1993)

eve protein is expressed in the first progeny of NBs 1-1, 4-2, and 5-2.

(Doe, 1992)

The position of run protein stripes was compared to that of other segmentation genes. The eve protein stripes lie anterior to the run protein stripes but overlap them partially. Two rows of eve expression are anterior to a two-row region of overlap with run followed by two rows of run expression and then two rows of non-expression before the next eve stripe.

(Kania et al., 1990)

eve protein is expressed in a complementary pattern to ftz protein. eve and ftz expression domains overlap at earlier stages of development, and then after stripe sharpening appear to be mutually exclusive, perhaps due to the regulation of ftz by eve.

(Kellerman et al., 1990)

In the early embryo,eve protein is expressed at low levels in a broad band from ~20% to ~70% egglength, as embryogenesis continues, the eve expression pattern is resolvedinto seven stripes of expression in every odd-numbered parasegemt. Thisparir-rule pattern is first visable at the end of the cleavage stage, andpersists through gastrulation and germ band elongation, where the stripes areresolved to span approximately three cells each. At the beginning of germ bandelongation, seven additional stripes of approximately two cells each can bedetected in the even-numbered parasegments. At this time, the anterior boarderof the eve stripes becomes well defined and sharp. Prior to germ bandretraction the segmentally repeated pattern disappears, and eve expressionpersists only in the posterior-most region of the germ band. As germ bandretaction begins, eve protein is detected in the neurogenic region of theembyo, and is observed in clusters of approximately four to six cells on eitherside of the ventral furrow in a segmentally repeated fashion. Prior to thecompletion of germ band retraction, lateral clusters of eve expressing cellsappear. Ultimately eve expression is detected in a subset of neurons in eachsegment, and this expression persists through embryonic and larval development.

(Frasch et al., 1987)

In the early embryo,eve protein is expressed at low levels in a broad band from ~20% to ~70% egglength, as embryogenesis continues, the eve expression pattern is resolvedinto seven stripes of expression in every odd-numbered parasegemt. Thisparir-rule pattern is first visable at the end of the cleavage stage, andpersists through gastrulation and germ band elongation, where the stripes areresolved to span approximately three cells each. At the beginning of germ bandelongation, seven additional stripes of approximately two cells each can bedetected in the even-numbered parasegments. At this time, the anterior boarderof the eve stripes becomes well defined and sharp. Prior to germ bandretraction the segmentally repeated pattern disappears, and eve expressionpersists only in the posterior-most region of the germ band. As germ bandretaction begins, eve protein is detected in the neurogenic region of theembryo, and is observed in clusters of approximately four to six cells oneither side of the ventral furrow in a segmentally repeated fashion. Prior tothe completion of germ band retraction, lateral clusters of eve expressingcells appear. Ultimately eve expression is detected in a subset of neurons ineach segment, and this expression persists through embryonic and larvaldevelopment.

(MacDonald et al., 1986)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Han et al., 2002, Gursky et al., 2001, Frasch et al., 1987)

Expression Deduced from Reporters

Reporter: P{ChAT-GAL4.7.4}

Stage

Tissue/Position (including subcellular localization)

Reference

cholinergic neuron

(Baines et al., 2002)

larval stage

larval ventral nerve cord | restricted

(Nässel et al., 2008)

embryonic/larval protocerebrum | restricted

(Nässel et al., 2008)

Rh6 photoreceptor of Bolwig organ

(Keene et al., 2011)

Rh5 photoreceptor of Bolwig organ

(Keene et al., 2011)

embryonic/larval optic lobe | restricted

(Keene et al., 2011)

first instar larval stage

EL neuron | subset

(Heckscher et al., 2015)

cholinergic neuron

(Heckscher et al., 2015)

adult stage

cholinergic neuron

(Boerner and Duch, 2010, Wu et al., 2010, Zhou et al., 2008, Beramendi et al., 2007, Wittmann et al., 2001)

neuron | subset

(Wittmann et al., 2001)

adult optic lobe

(Nässel et al., 2008)

adult protocerebrum

(Nässel et al., 2008)

adult deutocerebrum

(Nässel et al., 2008)

adult gnathal ganglion

(Nässel et al., 2008)

adult olfactory receptor neuron

(Nässel et al., 2008)

antenna

(Nässel et al., 2008)

maxillary palpus

(Nässel et al., 2008)

adult antennal lobe glomerulus

(Nässel et al., 2008)

lamina tangential neuron

(Kolodziejczyk et al., 2008)

lamina | distal

(Kolodziejczyk et al., 2008)

cholinergic neuron | subset

(Hamada et al., 2008)

AC thermosensory neuron

(Hamada et al., 2008)

cholinergic neuron of adult gnathal ganglion | subset

(Zhou et al., 2008)

LNd neuron | subset

(Johard et al., 2009)

Pdf negative s-LNv neuron

(Johard et al., 2009)

neuron | subset of adult brain

(Chen et al., 2012)

dorsal anterior lateral neuron of the protocerebrum

(Chen et al., 2012)

ellipsoid body

Comment: strong expression

(Chen et al., 2012)

adult mushroom body

Comment: strong expression

(Chen et al., 2012)

eye

Comment: strong expression

(Chen et al., 2012)

antennal lobe projection neuron

Comment: faint expression

(Chen et al., 2012)

lamina | restricted

(Varija Raghu et al., 2011)

medulla | restricted

(Varija Raghu et al., 2011)

lobula | restricted

(Varija Raghu et al., 2011)

lobula plate | restricted

(Varija Raghu et al., 2011)

transmedullary neuron Tm1

(Varija Raghu et al., 2011)

transmedullary neuron Tm2

(Varija Raghu et al., 2011)

transmedullary neuron Tm4

(Varija Raghu et al., 2011)

transmedullary neuron Tm4a

(Varija Raghu et al., 2011)

transmedullary neuron Tm7

(Varija Raghu et al., 2011)

transmedullary neuron Tm8

(Varija Raghu et al., 2011)

transmedullary neuron Tm11

(Varija Raghu et al., 2011)

transmedullary neuron Tm12

(Varija Raghu et al., 2011)

transmedullary neuron Tm15

(Varija Raghu et al., 2011)

transmedullary neuron Tm22

(Varija Raghu et al., 2011)

transmedullary neuron Tm24

(Varija Raghu et al., 2011)

transmedullary Y neuron TmY2

(Varija Raghu et al., 2011)

transmedullary Y neuron TmY5

(Varija Raghu et al., 2011)

transmedullary Y neuron TmY9

(Varija Raghu et al., 2011)

transmedullary Y neuron TmY10

(Varija Raghu et al., 2011)

transmedullary Y neuron TmY11

(Varija Raghu et al., 2011)

transmedullary Y neuron TmY12

(Varija Raghu et al., 2011)

medullary intrinsic neuron Mi2

(Varija Raghu et al., 2011)

medullary intrinsic neuron Mi7

(Varija Raghu et al., 2011)

medullary intrinsic neuron Mi11

(Varija Raghu et al., 2011)

proximal medullary amacrine neuron Pm1

(Varija Raghu et al., 2011)

proximal medullary amacrine neuron Pm1a

(Varija Raghu et al., 2011)

medullary tangential neuron Mt4

(Varija Raghu et al., 2011)

medullary tangential neuron Mt10

(Varija Raghu et al., 2011)

T neuron T2

(Varija Raghu et al., 2011)

T neuron T4

(Varija Raghu et al., 2011)

translobula plate neuron Tlp2

(Varija Raghu et al., 2011)

translobula plate neuron Tlp3

(Varija Raghu et al., 2011)

lobula columnar neuron LC1

(Varija Raghu et al., 2011)

lobula columnar neuron LC2

(Varija Raghu et al., 2011)

lobula tangential neuron Lt6

(Varija Raghu et al., 2011)

transmedullary neuron ChaTmnew1

(Varija Raghu et al., 2011)

transmedullary neuron ChaTmnew2

(Varija Raghu et al., 2011)

transmedullary neuron ChaTmnew3

(Varija Raghu et al., 2011)

T neuron ChaTnew1

(Varija Raghu et al., 2011)

transmedullary Y neuron ChaTmYnew1

(Varija Raghu et al., 2011)

medullary tangential neuron ChaMtnew1

(Varija Raghu et al., 2011)

medullary intrinsic neuron ChaMinew1

(Varija Raghu et al., 2011)

medullary intrinsic neuron ChaMinew2

(Varija Raghu et al., 2011)

medullary intrinsic neuron ChaMinew3

(Varija Raghu et al., 2011)

lobula columnar neuron ChaLcnnew1

(Varija Raghu et al., 2011)

lobula intrinsic neuron ChaLinew1

(Varija Raghu et al., 2011)

lobula plate intrinsic neuron ChaLPinew1

(Varija Raghu et al., 2011)

cholinergic neuron of adult antennal lobe

(Zhou et al., 2008)

adult mushroom body beta-lobe

(Johard et al., 2008)

adult mushroom body gamma-lobe

(Johard et al., 2008)

medulla non-directional M6 local neuron 2

(Chin et al., 2014)

medulla non-directional M6 local neuron 6

(Chin et al., 2014)

Reporter: P{CQ2-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

U neuron

(Landgraf et al., 2003)

Reporter: P{EL-GAL4-eveRC}

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

(Ping and Tsunoda, 2011)

embryonic/larval motor neuron | subset

(Heckscher et al., 2015)

(Heckscher et al., 2015)

embryonic/larval brain | restricted

(Heckscher et al., 2015)

Reporter: P{eve.st3-GAL4.S}

Stage

Tissue/Position (including subcellular localization)

Reference

parasegment 5

(Bloomington Drosophila Stock Center, 2017)

Reporter: P{eve'-tau/lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

(Wolf et al., 1998)

(Wolf et al., 1998)

Reporter: P{eve-GAL4.eme}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

abdominal dorsal transverse muscle 1 founder cell

(Bataillé et al., 2010)

(Bataillé et al., 2010)

dorsal oblique muscle 1

(Bataillé et al., 2010)

dorsal oblique muscle 2

(Bataillé et al., 2010)

Reporter: P{eve-GAL4.RKK}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

(Renden et al., 2001)

third instar larval stage L2

(Renden et al., 2001)

motor neuron of larval ventral nerve cord | restricted

(Repnikova et al., 2010)

Reporter: P{eve-GAL4.RN2}

Stage

Tissue/Position (including subcellular localization)

Reference

(Kuzin et al., 2005, Landgraf et al., 2003)

(Kuzin et al., 2005, Landgraf et al., 2003)

(Kuzin et al., 2005, Landgraf et al., 2003)

embryonic stage 16

Comment: reference states 13 hours of developmental time

(Bottenberg et al., 2009, Fujioka et al., 2003)

(Fujioka et al., 2003)

Comment: reference states 13 hours of developmental time

(Bottenberg et al., 2009, Fujioka et al., 2003)

dendrite of motor neuron

Comment: reference states 21 hours of developmental time

(Bottenberg et al., 2009)

Reporter: P{eve-GAL4.RRa}

Stage

Tissue/Position (including subcellular localization)

Reference

(Fujioka et al., 2003)

third instar larval stage

(Fujioka et al., 2003)

A1-7 DA1 motor neuron

(Fushiki et al., 2016)

(Hasegawa et al., 2016, Zwart et al., 2016, Hartwig et al., 2008)

(Hasegawa et al., 2016, Hartwig et al., 2008)

Reporter: P{eve-GAL4.RRC}

Stage

Tissue/Position (including subcellular localization)

Reference

(Baines et al., 2001)

(Baines et al., 2001)

embryonic stage 10 -- third instar larval stage

(Baines et al., 2001)

larval intersegmental nerve

(Landgraf et al., 2003)

(Landgraf et al., 2003)

(Landgraf et al., 2003)

(Landgraf et al., 2003)

(Baines et al., 1999, Baines et al., 1999)

(Baines et al., 1999, Baines et al., 1999)

(Baines et al., 1999, Baines et al., 1999)

Reporter: P{eve-GAL4.RRK}

Stage

Tissue/Position (including subcellular localization)

Reference

(Bloomington Drosophila Stock Center, 2017, Fujioka et al., 2003)

embryonic stage 16 -- second instar larval stage

(Bloomington Drosophila Stock Center, 2017, Fujioka et al., 2003)

(Baines et al., 2002)

(Baines et al., 2002)

Reporter: P{eve-lacZ1.7}

Stage

Tissue/Position (including subcellular localization)

Reference

organism | 0-80% egg length

(Small et al., 1992)

Reporter: P{eve-lacZ5.2}

Stage

Tissue/Position (including subcellular localization)

Reference

organism | pair rule expression pattern | restricted

Comment: eve stripes 2, 3, 7

(Stanojevic et al., 1991)

embryonic stage 6 -- 17

(Harding et al., 1989)

Reporter: P{eve-lacZ5.9}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 6 -- 17

(Harding et al., 1989)

embryonic stage 9 -- 17

(Harding et al., 1989)

Reporter: P{eve-lacZ6.3}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 6 -- 17

(Harding et al., 1989)

embryonic stage 9 -- 17

(Harding et al., 1989)

embryonic stage 11

(Sinclair et al., 1992)

adult stage

hindgut

(Gorfinkiel et al., 1999)

Reporter: P{eve-lacZ8.0}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 17

(Harding et al., 1989)

embryonic stage 9 -- 17

(Harding et al., 1989)

Reporter: P{eve-lacZ.C}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

(Small et al., 1996)

parasegment 5

(Small et al., 1996)

parasegment 13

(Small et al., 1996)

Comment: eve stripes 3 and 7

(Yan et al., 1996)

Reporter: P{evestripe2-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

(Gray et al., 1994)

(Small et al., 1996)

Reporter: P{lacZ^{eve.PΔbcd1-kr3,bcd2}}

Stage

Tissue/Position (including subcellular localization)

Reference

organism | pair rule expression pattern | restricted

Comment: eve stripes 2, 3, 7

(Stanojevic et al., 1991)

Reporter: P{lacZ^{eve.PΔkr1,kr2,kr4,kr6}}

Stage

Tissue/Position (including subcellular localization)

Reference

organism | pair rule expression pattern | restricted

Comment: eve stripes 2, 3, 7

(Stanojevic et al., 1991)

Reporter: P{lacZ^{eve.PΔkr1--kr6}}

Stage

Tissue/Position (including subcellular localization)

Reference

organism | pair rule expression pattern | restricted

Comment: eve stripes 2, 3, 7

(Stanojevic et al., 1991)

Reporter: P{MSE-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

organism | anterior | restricted

Comment: anterior stripe

(Jiang et al., 1992)

embryonic stage 16 -- first instar larval stage

Comment: eve stripe 2

(Kirov et al., 1994)

organism | anterior

(Small et al., 1992)

Reporter: P{RN2O-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

(Baines, 2003)

View Dmel\eve in GBrowse 2

(Baines, 2003)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eve

View exonic expression by tissue for Dmel\eve

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000606

DRscDB

36039/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0000606

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2328-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0000606

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 34 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 61 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eve

Transgenic constructs containing regulatory region of eve

Aberrations (Deficiencies and Duplications) ( 15 )

Inferred from experimentation ( 15 )

Gene not disrupted in

Ab(2R)55-20

(Goldstein et al., 2001)

Df(2R)61-25

(Goldstein et al., 2001)

Df(2R)64-10

(Goldstein et al., 2001)

Df(2R)520

(Goldstein et al., 2001, Bour et al., 1995)

Df(2R)P402

(Ranganayakulu et al., 1995)

Df(2R)stan2

(Goldstein et al., 2001)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal (with Df(2R)BSC158)

lethal (with Df(2R)X1)

lethal (with eve¹)

eve⁵

lethal (with eve⁵)

eve¹

lethal | heat sensitive

eve^hs.PS

lethal | recessive

lethal - all die during embryonic stage

eve^ΔS2E

lethal - all die during embryonic stage, with Scer\GAL4^h-1J3

eve^UAS.cBa

lethal - all die during embryonic stage, with Scer\GAL4^how-24B

eve^UAS.cBa

lethal - all die during embryonic stage, with Scer\GAL4^{l(3)31-1-31-1}

eve^UAS.cBa

lethal - all die during embryonic stage | recessive

eve^unspecified

partially lethal - majority die, with Scer\GAL4^pnr-MD237

eve^GD1643

viable

eve^hb8Δ

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

eve^GD1643

viable, with Scer\GAL4^Mef2.PR

eve^GD1643

viable, with Scer\GAL4^tin.CΔ4

eve^GD1643

Other Phenotypes

Allele

abnormal cell adhesion

eve³

abnormal cell polarity | gastrula stage

eve³

abnormal cell polarity | gastrula stage | somatic clone, with Scer\GAL4^{VP16.mat.αTub67C}

eve^UAS.cBa

abnormal developmental rate

eve^hb8Δ

abnormal neuroanatomy

abnormal neuroanatomy, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

abnormal neuroanatomy, with Scer\GAL4^eg-Mz360

eve^UAS.cBa

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

eve^UAS.cBa

abnormal neuroanatomy, with Scer\GAL4^Vap.P0201

eve^UAS.cBa

abnormal neuroanatomy | embryonic stage 16, with Ppt1^GD3286

eve^{2xCQ.RC.G4DBD}

abnormal neuroanatomy | embryonic stage 17, with Ppt1^GD3286

eve^{2xCQ.RC.G4DBD}

abnormal planar polarity

eve³

decreased occurrence of cell division | larval stage (with eve¹)

eve⁵

decreased occurrence of cell division | larval stage (with eve⁵)

eve¹

increased cell death | embryonic stage | recessive

eve¹

pair rule phenotype

pair rule phenotype, with Df(2R)eve, eve³

pair rule phenotype, with Df(2R)eve, eve^EGNAY

eve³

pair rule phenotype, with Df(2R)eve, eve^EGNPA

eve³

pair rule phenotype, with Df(2R)eve, eve^EGNΔLFK

eve³

pair rule phenotype, with eve³

pair rule phenotype, with eve³/Df(2R)eve

pair rule phenotype, with eve^EGNAY

eve³

pair rule phenotype, with eve^EGNPA

eve³

pair rule phenotype, with eve^EGNΔLFK

eve³

pair rule phenotype (with Df(2R)eve), with eve^EGNAY

eve³

pair rule phenotype (with Df(2R)eve), with eve^EGNPA

eve³

pair rule phenotype (with Df(2R)eve), with eve^EGNΔLFK

eve³

pair rule phenotype | embryonic stage | recessive

eve^unspecified

pair rule phenotype | heat sensitive

eve^hs.PS

some die during embryonic stage

eve^ΔS2E

some die during embryonic stage, with Scer\GAL4^h-1J3

eve^UAS.cBa

some die during embryonic stage, with Scer\GAL4^how-24B

eve^UAS.cBa

some die during embryonic stage, with Scer\GAL4^{l(3)31-1-31-1}

eve^UAS.cBa

some die during embryonic stage | recessive

eve^unspecified

some die during pupal stage, with Scer\GAL4^pnr-MD237

eve^GD1643

wild-type

Phenotype manifest in

Allele

abdominal 2 dorsal acute muscle 1

eve¹

abdominal 3 dorsal acute muscle 1

eve¹

abdominal 3 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 3 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 3 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 3 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 3 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 3 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 3 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 3 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 3 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 3 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 4 dorsal acute muscle 1

eve¹

abdominal 4 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 4 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 4 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 4 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 4 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 4 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 4 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 4 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 4 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 4 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 5 dorsal acute muscle 1

eve¹

abdominal 5 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 5 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 5 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 5 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 5 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 5 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 5 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 5 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 5 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal 5 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal 6 dorsal acute muscle 1

eve¹

abdominal 7 dorsal acute muscle 1

eve¹

abdominal anterior fascicle & abdominal segment 3

eve¹

abdominal anterior fascicle & abdominal segment 4

eve¹

abdominal anterior fascicle & abdominal segment 5

eve¹

abdominal posterior fascicle & abdominal segment 3, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal posterior fascicle & abdominal segment 3, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal posterior fascicle & abdominal segment 4, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal posterior fascicle & abdominal segment 4, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal posterior fascicle & abdominal segment 5, with Scer\GAL4^elav-C155

eve^UAS.cBa

abdominal posterior fascicle & abdominal segment 5, with Scer\GAL4^ftz.ng

eve^UAS.cBa

abdominal segment 2

eve⁴

abdominal segment 3 & somatic muscle

eve¹

abdominal segment 4

eve⁴

abdominal segment 4 & somatic muscle

eve¹

abdominal segment 5 & somatic muscle

eve¹

abdominal segment 6

eve⁴

abdominal segment 8

eve⁴

ectoderm | extended germ band stage

aCC neuron, with Df(2R)eve

eve^ΔRP2A

aCC neuron, with Df(2R)eve, eve^ΔRP2A

eve^ΔRP2B

aCC neuron, with Df(2R)eve, eve^ΔRP2B

eve^ΔRP2A

adult heart, with eve^emeΔNS

eve^unspecified

adult heart, with eve^unspecified

eve^emeΔNS

cardiac outflow muscle, with Scer\GAL4^how-24B

eve^UAS.cBa

cardioblast, with Scer\GAL4^how-24B

eve^UAS.cBa

cephalic furrow

cuticle

eve^hb.PP

denticle | ectopic

eve^2R-226-8

denticle belt

denticle belt, with Df(2R)eve, eve³

denticle belt, with Df(2R)eve, eve^EGNAY

eve³

denticle belt, with Df(2R)eve, eve^EGNPA

eve³

denticle belt, with Df(2R)eve, eve^EGNΔLFK

eve³

denticle belt, with eve³

denticle belt, with eve³/Df(2R)eve

denticle belt, with eve^EGNAY

eve³

denticle belt, with eve^EGNPA

eve³

denticle belt, with eve^EGNΔLFK

eve³

denticle belt (with Df(2R)eve), with eve^EGNAY

eve³

denticle belt (with Df(2R)eve), with eve^EGNPA

eve³

denticle belt (with Df(2R)eve), with eve^EGNΔLFK

eve³

dMP2 neuron, with Scer\GAL4^Vap.P0201

eve^UAS.cBa

dorsal transverse muscle, with Scer\GAL4^kirre.PR

eve^UAS.cBa

eve^1.27

embryo

eve¹

embryo, with Df(2R)eve, eve³

embryo, with Df(2R)eve, eve^EGNAY

eve³

embryo, with Df(2R)eve, eve^EGNPA

eve³

embryo, with Df(2R)eve, eve^EGNΔLFK

eve³

embryo, with eve³

embryo, with eve³/Df(2R)eve

embryo, with eve^EGNAY

eve³

embryo, with eve^EGNPA

eve³

embryo, with eve^EGNΔLFK

eve³

embryo (with Df(2R)eve), with eve^EGNAY

eve³

embryo (with Df(2R)eve), with eve^EGNPA

eve³

embryo (with Df(2R)eve), with eve^EGNΔLFK

eve³

embryo | heat sensitive

eve^hs.PS

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle, with Df(2R)eve, eve³

embryonic/first instar larval cuticle, with Df(2R)eve, eve^EGNAY

eve³

embryonic/first instar larval cuticle, with Df(2R)eve, eve^EGNPA

eve³

embryonic/first instar larval cuticle, with Df(2R)eve, eve^EGNΔLFK

eve³

embryonic/first instar larval cuticle, with eve³

embryonic/first instar larval cuticle, with eve³/Df(2R)eve

embryonic/first instar larval cuticle, with eve^EGNAY

eve³

embryonic/first instar larval cuticle, with eve^EGNPA

eve³

embryonic/first instar larval cuticle, with eve^EGNΔLFK

eve³

embryonic/first instar larval cuticle (with Df(2R)eve), with eve^EGNAY

eve³

embryonic/first instar larval cuticle (with Df(2R)eve), with eve^EGNPA

eve³

embryonic/first instar larval cuticle (with Df(2R)eve), with eve^EGNΔLFK

eve³

embryonic/first instar larval cuticle | heat sensitive

eve^hs.PS

embryonic/larval fat body

eve³

embryonic/larval heart anchoring cell, with Scer\GAL4^how-24B

eve^UAS.cBa

embryonic/larval somatic muscle

eve¹

embryonic/larval visceral muscle

eve¹

embryonic heart anchoring cell primordium, with Scer\GAL4^how-24B

eve^UAS.cBa

embryonic mesothoracic segment

eve⁴

embryonic midgut constriction

eve^unspecified

embryonic primordium of adult hindgut precursor, with Scer\GAL4^cad-em459

eve^UAS.cBa

embryonic segment

embryonic segment | heat sensitive

eve^hs.PS

epidermis & larval midgut & embryo

eve^unspecified

EW neuron, with Scer\GAL4^eg-Mz360

eve^UAS.cBa

germ band | gastrula stage | somatic clone, with Scer\GAL4^{VP16.mat.αTub67C}

eve^UAS.cBa

heart primordium, with Scer\GAL4^how-24B

eve^UAS.cBa

larval abdominal intersegmental nerve

eve^{2xCQ.RC.G4DBD}

larval abdominal intersegmental nerve, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

larval abdominal segmental nerve, with Scer\GAL4^elav.PLu

eve^UAS.cBa

larval brain & neuroblast (with eve¹)

eve⁵

larval brain & neuroblast (with eve⁵)

eve¹

larval intersegmental nerve

larval intersegmental nerve, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

larval intersegmental nerve, with Scer\GAL4^elav.PLu

eve^UAS.cBa

larval mesothoracic intersegmental nerve

eve^{2xCQ.RC.G4DBD}

larval mesothoracic intersegmental nerve, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

larval metathoracic intersegmental nerve

eve^{2xCQ.RC.G4DBD}

larval metathoracic intersegmental nerve, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

larval prothoracic intersegmental nerve

eve^{2xCQ.RC.G4DBD}

larval prothoracic intersegmental nerve, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

mitotic domain 1 | extended germ band stage

mitotic domain 2

eve³

nucleus | increased number, with Scer\GAL4^kirre.PR

eve^UAS.cBa

parasegment

parasegment 1 | precursor

eve³

parasegment 3 | heat sensitive

eve¹

eve^hs.PS

parasegment 4

eve¹

parasegment 4 | heat sensitive

eve^hs.PS

parasegment 5

eve¹

parasegment 5 | heat sensitive

eve^hs.PS

parasegment 6

eve¹

parasegment 6 | heat sensitive

eve^hs.PS

pCC neuron, with Df(2R)eve

eve^ΔRP2A

pCC neuron, with Df(2R)eve, eve^ΔRP2A

eve^ΔRP2B

pCC neuron, with Df(2R)eve, eve^ΔRP2B

eve^ΔRP2A

pericardial cell

eve¹

presumptive embryonic/larval central nervous system, with Scer\GAL4^elav.PLu

eve^UAS.cBa

presumptive embryonic/larval nervous system

eve¹

Download All DIOPT Orthologs

RP2 motor neuron, with Df(2R)eve

eve^ΔRP2A

RP2 motor neuron, with Df(2R)eve, eve^ΔRP2A

eve^ΔRP2B

RP2 motor neuron, with Df(2R)eve, eve^ΔRP2B

eve^ΔRP2A

U neuron, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

U neuron | embryonic stage 13

eve^{2xCQ.RC.G4DBD}

ventral acute muscle 2, with Scer\GAL4^kirre.PR

eve^UAS.cBa

VUM motor neuron

eve^ΔRP2A

VUM neuron, with Rdl^UAS.cSa

eve^{2xCQ.RC.G4DBD}

Orthologs

Downloads

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\EVX1

6 of 15

Yes

Hsap\EVX2

6 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Evx1

7 of 15

Yes

Mmus\Evx2

6 of 15

Yes

Mmus\Alx3

1 of 15

Rattus norvegicus (Norway rat) (3)

Rnor\Evx2

3 of 13

Yes

Rnor\Evx1

2 of 13

Yes

Rnor\NEWGENE_1565788

2 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\evx1

3 of 12

Yes

Xtro\evx2

3 of 12

Yes

Danio rerio (Zebrafish) (3)

Drer\evx2

5 of 15

Yes

Drer\eve1

4 of 15

Yes

Drer\evx1

4 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\vab-7

7 of 15

Yes

Cele\ceh-30

1 of 15

Cele\ceh-31

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\HB-1

1 of 9

Yes

Atha\HB-7

1 of 9

Yes

Atha\HB-12

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\YHP1

1 of 15

Yes

Scer\YOX1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190EWC )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\eve

Drosophila persimilis

Dper\GL16768

Drosophila willistoni

Dwil\eve

Drosophila virilis

Dvir\eve

Drosophila mojavensis

Dmoj\GI20020

Drosophila grimshawi

Dgri\eve

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509BT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022663

Glossina morsitans

Tsetse fly

Gmor\GMOY002956

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01564

Mayetiola destructor

Hessian fly

Mdes\Mdes005381

Mayetiola destructor

Hessian fly

Mdes\Mdes005387

Mayetiola destructor

Hessian fly

Mdes\Mdes005386

Mayetiola destructor

Hessian fly

Mdes\Mdes005382

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007369

Anopheles gambiae

Malaria mosquito

Agam\AGAP010279

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013533

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08IT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009710

Bombyx mori

Silkmoth

Bmor\BGIBMGA009709

Danaus plexippus

Monarch butterfly

Dple\DPOGS200005-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011193

Apis florea

Little honeybee

Aflo\2166343490

Apis mellifera

Western honey bee

Amel\eve

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16468

Bombus terrestris

Buff-tailed bumblebee

Bter\15209109

Linepithema humile

Argentine ant

Lhum\LH15244

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0011ca

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG012573

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06005

Tribolium castaneum

Red flour beetle

Tcas\TC009469

Pediculus humanus

Human body louse

Phum\PHUM236390

Cimex lectularius

Bed bug

Clec\CLEC004158

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI068579

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003551

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06977

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0C5Q )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012490

Strigamia maritima

European centipede

Smar\SMAR003413

Strigamia maritima

European centipede

Smar\SMAR004173

Ixodes scapularis

Black-legged tick

Isca\ISCW001025

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g08870

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_347542

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0JVN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Eve

Ciona intestinalis

Vase tunicate

Cint\evx-a

Gallus gallus

Domestic chicken

Ggal\EVX2

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028702

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (22)

Gene Symbol

Score

Source

Alignment

1 of 10

CG9876

1 of 10

CG11294

1 of 10

CG32532

1 of 10

eyg

1 of 10

gsb

1 of 10

gsb-n

1 of 10

Gsc

1 of 10

otp

1 of 10

Poxm

1 of 10

Poxn

1 of 10

Pph13

1 of 10

prd

1 of 10

Ptx1

1 of 10

repo

1 of 10

toe

1 of 10

unc-4

1 of 10

Vsx1

1 of 10

Vsx2

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EVX1; even-skipped homeobox 1

6 of 15

142996

EVX2; even-skipped homeobox 2

6 of 15

142991

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

eve - Abd-B

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

eve - Antp

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

eve - Scr

bimolecular fluorescence complementation, fluorescence microscopy

(Baëza et al., 2015)

eve - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018, Baëza et al., 2015)

eve - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018, Baëza et al., 2015)

eve - dbo

two hybrid

(Hu et al., 2017.6.13)

eve - exd

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

eve - gro

two hybrid, pull down, autoradiography

(Braid et al., 2010, Kobayashi et al., 2001)

eve - nmo

anti tag coimmunoprecipitation, anti tag western blot, two hybrid, enzymatic study, western blot

(Braid et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

beat-Ia

(Landgraf et al., 1999)

enhanceable

beat-Ia

(Zarin et al., 2014)

enhanceable

beat-Ia|unc-5

(Zarin et al., 2014)

suppressible

beat-Ia|unc-5

(Zarin et al., 2014)

eve|trol

suppressible

CycE

(Park et al., 2001)

enhanceable

egl

(Bullock et al., 2004)

Rdl|eve

enhanceable

Fas2

(Sanchez-Soriano and Prokop, 2005)

enhanceable

Fas2

(Zarin et al., 2014)

suppressible

ftz

(Hughes and Krause, 2001)

enhanceable

grn

(Zarin et al., 2014, Garces and Thor, 2006)

enhanceable

gro

(Kobayashi et al., 2001)

enhanceable

Nrg

(Zarin et al., 2014)

suppressible

(Zarin et al., 2014, Labrador et al., 2005)

enhanceable

(Zarin et al., 2014)

enhanceable

zfh1

(Zarin et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

fru

enhanceable

(Goto et al., 2011)

ftz

suppressible

(Hughes and Krause, 2001)

Gug

enhanceable

(Zhang et al., 2002)

lbe

suppressible

(Buechling et al., 2009)

Nrg

enhanceable

(Zarin et al., 2014)

trol

enhanceable

(Park et al., 2001, Park and Datta, 1998, Park et al., 1998)

trol

suppressible

(Park et al., 1998)

enhanceable

(Zarin et al., 2014)