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Gene Dmel\eve

General Information
Symbol	Dmel\eve	Species	D. melanogaster
Name	even skipped	Annotation symbol	CG2328
Feature type	protein_coding_gene	FlyBase ID	FBgn0000606
Gene Model Status	Current	Stock availability	27 publicly available
Also Known As	E(eve)
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46C10-46C10	Sequence location	2R:5,866,746..5,868,284 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene even skipped is referred to in FlyBase by the symbol Dmel\eve (CG2328, FBgn0000606). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process: motor axon guidance; regulation of axonogenesis; negative regulation of cardioblast cell fate specification; positive regulation of transcription from RNA polymerase II promoter; germ-band extension; negative regulation of transcription from RNA polymerase II promoter; cephalic furrow formation. 133 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; hypodermal muscle of larval abdomen; presumptive embryonic/larval nervous system; embryonic/larval neuron; multi-cell-component structure; primordium; peripheral nervous system; cuticle; portion of tissue. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox; Homeobox, conserved site; Homeobox, eukaryotic; Homeodomain-like; Homeodomain-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1622897_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eve. Gene sequence location is 2R:5866746..5868284.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	eve: even skipped Homozygous lethal; embryos homozygous for a null allele or a deficiency fail to undergo segmentation and their ventral surfaces are covered by a lawn of short denticles pointed toward the midline; denticles in the anterior region show thoracic characteristics suggesting that segmental identities persist in the absence of segmentation. All derivatives of gnathal segments are missing, such as maxillary sense organs, cirri, mouth hooks, labial sense organs and the mandibular parts of the cephalopharyngeal skeleton; the labrum, antennal sense organs, and a rudimentary skeleton are the only remains of the larval head. Posteriorally, anal plates and some sensory organs persist as do remnants of spiracles, filzkorper, and tufts. Homozygotes and hemizygotes for hypomorphic alleles display pair-rule segmentation defects. Denticle bands and adjacent naked cuticle of the prothoracic, metathoracic and even-numbered abdominal segments removed; some naked cuticle of the adjacent segment removed as well (i.e., the odd numbered parasegments are removed). Combinations of alleles with Df(2R)eve raised at different temperatures can achieve an array of phenotypes between these extremes. Expression of eve is first detected at the eleventh nuclear division following fertilization; at this stage, eve protein is uniformly distributed among the nuclei, both at the periphery and deep within the egg; by the thirteenth nuclear division, the anterior one-third of the embryo is devoid of detectable protein; over the next 20 minutes, the antibody staining in the posterior two-thirds of the embryo becomes concentrated in seven transverse stripes four or five cells wide separated by stripes three to four cells wide with lower levels of staining. By the time of germ-band elongation, the seven stripes have become narrowed and sharply defined and seven new weakly expressing stripes, one to two cells wide, appear between the major stripes; during germ-band elongation all stripes gradually disappear. As eve stripes become more sharply defined so too do ftz stripes, no longer overlapping eve stripes, but forming a complementary pattern. At the same time, a group of expressing cells appears at the posterior end of the germ band; these cells form a ring around the anal plate during germ-band shortening. Also during germ-band shortening, a specific subset of sixteen neurons in each hemisegment of the CNS expresses eve product as does a row of cell clusters on either side of the dorsal midline; lateral to these clusters are curious rings of weakly staining cells; the dorsal cells do not appear to be neuronal (Frasch, Hoey, Rushlow, Doyle, and Levine, 1987, EMBO J. 6: 749-59; Frasch and Levine, 1987, Genes Dev. 1: 981-95). In homozygous eve1 embryos switched to restrictive temperature during neurogenesis, four specifically studied eve-expressing neurons in each hemisegment are found to persist; two of them develop normally, but two send axonal processes to abnormal destinations [Doe, Smouse, and Goodman, 1988, Nature (London) 333: 376-78]. Frasch and Levine observe that segmentation-gene-mutations generally have reciprocal effects on the expression of eve and ftz, leading them to postulate that their promoters respond reciprocally to the same positional cues. eve concluded to be an early pair-rule gene, since its expression is modified by gap-gene mutations, but not by most other pair-rule gene mutations nor by segment-polarity gene mutations. Three pair-rule genes do influence eve expression: in either eve or h genotypes, eve expression is reduced and in run embryos eve is overexpressed (Frasch and Levine, 1987). In eve embryos, en stripes do not appear (Macdonald, Ingham, and Struhl, 1986, Cell 47: 721-34). Ubx protein is detected at high level in odd-numbered parasegments from 7 through 13 rather than in every parasegment from 6 through 12 (Martinez-Arias, and White, 1988, Development 102: 325-38). ftz stripes are disrupted in regularity of position, size, and timing (Carroll and Scott, 1986, Cell 45: 113-26).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter sequence-specific distal enhancer binding RNA polymerase II transcription factor activity Sequence features BKN27879 HFA07614 References Mace et al., 2010, Bioinformatics 26(6): 761--769 Tchuraev and Galimzyanov, 2009, J. Theor. Biol. 259(4): 659--669 Slack et al., 2006, BMC Genet. 7: 33 McHale et al., 2011, Dev. Biol. 360(1): 230--240 Dobi et al., 2011, Fly 5(2): 68--75 Fowlkes et al., 2011, PLoS Genet. 7(10): e1002346
FB2011_10	References Gurunathan et al., 2004, BMC Bioinformatics 5: 202 Struffi et al., 2011, Development 138(19): 4291--4299 Grad et al., 2004, Bioinformatics 20(16): 2738--2750 Zamparo and Perkins, 2009, Bioinformatics 25(20): 2670--2676 Satija et al., 2008, Bioinformatics 24(10): 1236--1242 Bauer and Bailey, 2008, BMC Bioinformatics 9: 220 Clones MIP30861
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46C10-46C10   Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
Experimentally Determined Cytological Location
Cytogenetic map Notes References 46C3-46C11   (determined by in situ hybridisation)   (Frasch et al., 1987) 46C-46C   (determined by in situ hybridisation)   (MacDonald et al., 1986) 46C8-46F6   Complementation data from unspecified deficiency chromosomes.   (Goldstein et al., 1993)
Experimentally Determined Recombination Data
Location	2-58 (Tearle and Nusslein-Volhard, 1987) 2- (O'Brien et al., 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eve for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eve-RA FBtr0088390  NM_078946   1468   376
Additional Transcript Data & Comments
Reported size (kB)	1.4 (northern blot, sequence analysis) (MacDonald et al., 1986, Frasch et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eve-PA   FBpp0087478   40.0   376   9.73     NP_523670   AAF58865
Additional Polypeptide Data & Comments
Reported size (kDa)	376 (aa); 40 (kD predicted) (Frasch et al., 1987, MacDonald et al., 1986)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeobox, eukaryotic (IPR020479) Homeodomain-related (IPR012287) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1JGG
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58865   AF042709   BT028871   BT029151   BT128763   M14767 AAA28522   S81995   U32087 AAB05358   U32088 AAB05359   U32089 AAB05360   U32090 AAB05361   U32091 AAB05362   X05138 CAA28784   X05138 CAA28785   X78903
UniProtKB/Swiss-Prot	P06602
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160590 2R:5,863,302..5,863,310 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160591 2R:5,863,055..5,863,064 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160592 2R:5,863,075..5,863,084 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160593 2R:5,873,153..5,873,159 bound_moiety=tin-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160594 2R:5,863,093..5,863,102 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160595 2R:5,863,281..5,863,290 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160596 2R:5,865,706..5,865,728 bound_moiety=gt-XP evidence=experimental (Bergman et al., 2004, Small et al., 1991) protein binding site FBsf0000159786 2R:5,866,679..5,866,703 bound_moiety=eve-XP evidence=experimental (Hoey and Levine, 1988, Bergman et al., 2004) protein binding site FBsf0000160597 2R:5,866,747..5,866,762 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160598 2R:5,872,876..5,872,889 bound_moiety=pan-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160599 2R:5,865,220..5,865,229 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160600 2R:5,873,122..5,873,150 evidence=experimental bound_moiety=Med-XP (Bergman et al., 2004, Knirr and Frasch, 2001) protein binding site FBsf0000160601 2R:5,865,513..5,865,522 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160602 2R:5,865,374..5,865,399 bound_moiety=gt-XP evidence=experimental (Small et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160603 2R:5,863,179..5,863,187 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160604 2R:5,872,994..5,873,004 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Knirr and Frasch, 2001) protein binding site FBsf0000160605 2R:5,865,737..5,865,747 bound_moiety=Kr-XP evidence=experimental bound_moiety=bcd-XP (Bergman et al., 2004, Stanojevic et al., 1989, Small et al., 1991) protein binding site FBsf0000160606 2R:5,873,025..5,873,031 bound_moiety=tin-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160607 2R:5,865,526..5,865,534 evidence=experimental bound_moiety=bcd-XP (Bergman et al., 2004, Small et al., 1991) protein binding site FBsf0000160608 2R:5,861,451..5,861,474 bound_moiety=eve-XP evidence=experimental (Jiang et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160609 2R:5,863,265..5,863,277 bound_moiety=kni-XP evidence=experimental (Small et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160610 2R:5,873,024..5,873,034 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Knirr and Frasch, 2001) protein binding site FBsf0000160611 2R:5,863,455..5,863,463 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160612 2R:5,873,040..5,873,053 bound_moiety=pan-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160613 2R:5,865,788..5,865,797 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160614 2R:5,866,812..5,866,825 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160615 2R:5,866,601..5,866,621 bound_moiety=ttk-XP evidence=experimental (Read and Manley, 1992, Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160616 2R:5,873,162..5,873,174 bound_moiety=Med-XP evidence=experimental (Bergman et al., 2004, Knirr and Frasch, 2001) protein binding site FBsf0000160617 2R:5,865,543..5,865,552 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160618 2R:5,865,437..5,865,481 bound_moiety=gt-XP evidence=experimental (Bergman et al., 2004, Small et al., 1991) protein binding site FBsf0000160619 2R:5,873,172..5,873,183 bound_moiety=zfh1-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160620 2R:5,863,351..5,863,361 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160621 2R:5,866,683..5,866,709 evidence=experimental bound_moiety=prd-XP (Bergman et al., 2004, Treisman et al., 1991) protein binding site FBsf0000160622 2R:5,865,354..5,865,362 bound_moiety=bcd-XP evidence=experimental (Small et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160623 2R:5,865,304..5,865,314 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160624 2R:5,873,208..5,873,214 bound_moiety=tin-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160625 2R:5,863,084..5,863,098 bound_moiety=kni-XP evidence=experimental (Small et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160626 2R:5,863,107..5,863,121 bound_moiety=kni-XP evidence=experimental (Bergman et al., 2004, Small et al., 1996) protein binding site FBsf0000160627 2R:5,861,482..5,861,518 bound_moiety=eve-XP evidence=experimental (Jiang et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160628 2R:5,865,618..5,865,638 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160629 2R:5,865,794..5,865,803 evidence=experimental bound_moiety=hb-XP (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160630 2R:5,872,977..5,872,991 bound_moiety=Med-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160631 2R:5,873,192..5,873,207 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Knirr and Frasch, 2001) protein binding site FBsf0000160632 2R:5,866,477..5,866,488 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160633 2R:5,863,319..5,863,328 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160634 2R:5,866,610..5,866,642 bound_moiety=prd-XP evidence=experimental (Bergman et al., 2004, Treisman et al., 1991) protein binding site FBsf0000160635 2R:5,866,672..5,866,686 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160636 2R:5,865,375..5,865,383 bound_moiety=bcd-XP evidence=experimental (Bergman et al., 2004, Small et al., 1991) protein binding site FBsf0000160637 2R:5,865,831..5,865,841 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160638 2R:5,865,269..5,865,277 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1991, Bergman et al., 2004) protein binding site FBsf0000160639 2R:5,863,310..5,863,320 evidence=experimental bound_moiety=kni-XP (Small et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160640 2R:5,866,546..5,866,578 bound_moiety=ttk-XP evidence=experimental (Read and Manley, 1992, Bergman et al., 2004, Read et al., 1990) protein binding site FBsf0000160641 2R:5,873,217..5,873,230 bound_moiety=pan-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160642 2R:5,865,619..5,865,627 bound_moiety=bcd-XP evidence=experimental (Bergman et al., 2004, Small et al., 1991) protein binding site FBsf0000160643 2R:5,866,627..5,866,659 bound_moiety=eve-XP evidence=experimental (Bergman et al., 2004, Hoey and Levine, 1988) protein binding site FBsf0000160644 2R:5,866,777..5,866,790 evidence=experimental (Bergman et al., 2004, Read et al., 1990) protein binding site FBsf0000160645 2R:5,866,429..5,866,447 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160646 2R:5,865,502..5,865,510 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1991) protein binding site FBsf0000160647 2R:5,866,500..5,866,529 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160648 2R:5,865,646..5,865,691 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1991) protein binding site FBsf0000160649 2R:5,873,281..5,873,293 bound_moiety=pan-XP evidence=experimental (Bergman et al., 2004, Knirr and Frasch, 2001) protein binding site FBsf0000160650 2R:5,865,476..5,865,484 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1991) protein binding site FBsf0000160651 2R:5,863,130..5,863,139 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160652 2R:5,865,877..5,865,886 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989) protein binding site FBsf0000160653 2R:5,872,919..5,872,930 bound_moiety=Med-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160654 2R:5,866,638..5,866,666 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160655 2R:5,861,551..5,861,579 evidence=experimental (Bergman et al., 2004, Jiang et al., 1991) protein binding site FBsf0000160656 2R:5,861,523..5,861,535 bound_moiety=ttk-XP evidence=experimental (Bergman et al., 2004, Jiang et al., 1991, Read and Manley, 1992) protein binding site FBsf0000160657 2R:5,863,040..5,863,053 bound_moiety=kni-XP evidence=experimental (Bergman et al., 2004, Small et al., 1996) protein binding site FBsf0000160658 2R:5,865,355..5,865,364 bound_moiety=Kr-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160659 2R:5,865,712..5,865,721 bound_moiety=hb-XP evidence=experimental (Stanojevic et al., 1989, Bergman et al., 2004) protein binding site FBsf0000160660 2R:5,866,703..5,866,727 evidence=experimental (Read et al., 1990, Bergman et al., 2004) protein binding site FBsf0000160661 2R:5,866,856..5,866,880 evidence=experimental (Bergman et al., 2004, Read et al., 1990) protein binding site FBsf0000160662 2R:5,872,949..5,872,961 bound_moiety=Med-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160663 2R:5,861,474..5,861,484 evidence=experimental (Bergman et al., 2004, Jiang et al., 1991) protein binding site FBsf0000160664 2R:5,873,042..5,873,048 bound_moiety=tin-XP evidence=experimental (Knirr and Frasch, 2001, Bergman et al., 2004) protein binding site FBsf0000160665 2R:5,863,503..5,863,512 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Stanojevic et al., 1989)
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 15016
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 15     (Frasch et al., 1987) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 7   organism | pair rule expression pattern   (Nasiadka and Krause, 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17     (MacDonald et al., 1986) embryonic stage 3   organism | 20-70% egg length   (MacDonald et al., 1986) embryonic stage 4 -- 12   parasegment 1 & parasegment 3 & parasegment 5 & parasegment 7 & parasegment 9 & parasegment 11 & parasegment 13   (MacDonald et al., 1986) embryonic stage 13 -- 17   parasegment 1 -- parasegment 14   (MacDonald et al., 1986) ganglion mother cell | segmentally repeated   (MacDonald et al., 1986) larval stage     (MacDonald et al., 1986)
Additional Descriptive Data
	Ectopic eve expression is incapable of activating eve expression outside of its normal domain and causes a premature loss of transcripts within its normal domains of expression. (Manoukian and Krause, 1992) eve transcripts are first detected in stage 3 embryos, and displays a low level of expression throughout the embryo. The expression pattern is refined over the next four hours of development. eve expression exhibits a pair-rule pattern, and is expressed in a graded fashion, both along the anterior-posterior axis and the dorsal-ventral axis, with the highest levels of transcript being present in the dorsal-posterior regions. eve is expressed in odd-numbered parasegments in seven stripes, but later in development is expressed coincidently with en, in the posterior section of each parasegment. In the later stages of embryonic development, following germ band retraction, eve transcripts are detected in the neurogenic region in the ganglion mother cells of each segment. (MacDonald et al., 1986)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   cardioblast   (Bodmer, 1993) embryonic stage 8 -- 12   parasegment 1 -- parasegment 14   (MacDonald et al., 1986, Frasch et al., 1987) embryonic stage 13 -- 17   neurogenic region   (MacDonald et al., 1986, Frasch et al., 1987) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 3 -- 11   parasegment 1 & parasegment 3 & parasegment 5 & parasegment 7 & parasegment 9 & parasegment 11 & parasegment 13   (MacDonald et al., 1986, Frasch et al., 1987) blastoderm stage   organism | pair rule expression pattern   (Kania et al., 1990) embryonic stage 4 -- 5   organism | pair rule expression pattern   (Kellerman et al., 1990) organism | pair rule expression pattern   • nucleus (Small et al., 1991) embryonic cycle 14A   organism | pair rule expression pattern   • nucleus (Gursky et al., 2001) embryonic stage 9   neuroblast NB1-1   (Weiss et al., 1998) neuroblast NB7-1   (Weiss et al., 1998) embryonic stage 10   embryonic pericardial cell   (Lee and Frasch, 2000) embryonic stage 10 -- 11   RP2 neuron   (Alonso et al., 2001) aCC neuron   (Alonso et al., 2001) pCC neuron   (Alonso et al., 2001) cell | subset of mesoderm | dorsal of parasegment 2 -- parasegment 12   (Lawrence et al., 1995) Comment:small cluster of dorsal mesoderm cells in parasegments 2-12 and 14 cell | subset of mesoderm | dorsal of parasegment 2   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 3   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 4   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 5   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 6   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 7   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 8   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 9   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 10   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 11   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 12   (Lawrence et al., 1995) cell | subset of mesoderm | dorsal of parasegment 14   (Lawrence et al., 1995) embryonic stage 11   embryonic myoblast   (Han et al., 2002) cardioblast   (Crackower et al., 2002) embryonic stage 11 -- 12   RP2 neuron   (Belenkaya et al., 2002) embryonic heart cardioblast   (Belenkaya et al., 2002) embryonic stage 12   proctodeum | presumptive   (MacDonald et al., 1986, Frasch et al., 1987) aCC neuron   (Bhat and Apsel, 2004) pCC neuron   (Bhat and Apsel, 2004) fpCC neuron   (Bhat and Apsel, 2004) embryonic stage 12 -- 13   embryonic myoblast   (Yarnitzky et al., 1998) A1-7 dorsal acute muscle 1 | precursor   (Yarnitzky et al., 1998) mesothoracic dorsal acute muscle 1 | precursor   (Yarnitzky et al., 1998) metathoracic dorsal acute muscle 1 | precursor   (Yarnitzky et al., 1998) embryonic stage 12 -- 15   RP2 neuron   (Bhat and Apsel, 2004) RP2sib neuron   (Bhat and Apsel, 2004) embryonic stage 13   embryonic pericardial cell | subset   (Han and Bodmer, 2003) A1-7 dorsal acute muscle 1   (Han and Bodmer, 2003) embryonic stage 13 -- 15   embryonic pericardial cell   (Arquier et al., 2001) embryonic myoblast | dorsal & subset   (Arquier et al., 2001) embryonic stage 16   RP2 neuron   (Bossing et al., 1996) aCC neuron   (Bossing et al., 1996) pCC neuron   (Bossing et al., 1996) embryonic stage 17   RP2 neuron   (Bossing et al., 1996) aCC neuron   (Bossing et al., 1996) pCC neuron   (Bossing et al., 1996) inferred from author statements Stage Tissue/Position (including subcellular localization) Reference embryonic stage   U neuron   (Mellerick and Modica, 2002) EL neuron   (Mellerick and Modica, 2002)
Additional Descriptive Data
	eve protein is expressed in a complementary pattern to ftz protein. eve and ftz expression domains overlap at earlier stages of development, and then after stripe sharpening appear to be mutually exclusive, perhaps due to the regulation of ftz by eve. (Kellerman et al., 1990) In the early embryo,eve protein is expressed at low levels in a broad band from ~20% to ~70% egglength, as embryogenesis continues, the eve expression pattern is resolvedinto seven stripes of expression in every odd-numbered parasegemt. Thisparir-rule pattern is first visable at the end of the cleavage stage, andpersists through gastrulation and germ band elongation, where the stripes areresolved to span approximately three cells each. At the beginning of germ bandelongation, seven additional stripes of approximately two cells each can bedetected in the even-numbered parasegments. At this time, the anterior boarderof the eve stripes becomes well defined and sharp. Prior to germ bandretraction the segmentally repeated pattern disappears, and eve expressionpersists only in the posterior-most region of the germ band. As germ bandretaction begins, eve protein is detected in the neurogenic region of theembryo, and is observed in clusters of approximately four to six cells oneither side of the ventral furrow in a segmentally repeated fashion. Prior tothe completion of germ band retraction, lateral clusters of eve expressingcells appear. Ultimately eve expression is detected in a subset of neurons ineach segment, and this expression persists through embryonic and larvaldevelopment. (MacDonald et al., 1986) eve is expressed in two Eve pericadial cells (EPC) and one DA1 muscle per hemisegment in stage 13 embryos. (Han and Bodmer, 2003) eve protein is expressed in the first progeny of NBs 1-1, 4-2, and 5-2. (Doe, 1992) The position of run protein stripes was compared to that of other segmentation genes. The eve protein stripes lie anterior to the run protein stripes but overlap them partially. Two rows of eve expression are anterior to a two-row region of overlap with run followed by two rows of run expression and then two rows of non-expression before the next eve stripe. (Kania et al., 1990) eve is expressed in a segmentally repeated subset of heart precursor cells starting shortly after tin expression is observed in these cells. (Bodmer, 1993) In the early embryo,eve protein is expressed at low levels in a broad band from ~20% to ~70% egglength, as embryogenesis continues, the eve expression pattern is resolvedinto seven stripes of expression in every odd-numbered parasegemt. Thisparir-rule pattern is first visable at the end of the cleavage stage, andpersists through gastrulation and germ band elongation, where the stripes areresolved to span approximately three cells each. At the beginning of germ bandelongation, seven additional stripes of approximately two cells each can bedetected in the even-numbered parasegments. At this time, the anterior boarderof the eve stripes becomes well defined and sharp. Prior to germ bandretraction the segmentally repeated pattern disappears, and eve expressionpersists only in the posterior-most region of the germ band. As germ bandretaction begins, eve protein is detected in the neurogenic region of theembyo, and is observed in clusters of approximately four to six cells on eitherside of the ventral furrow in a segmentally repeated fashion. Prior to thecompletion of germ band retraction, lateral clusters of eve expressing cellsappear. Ultimately eve expression is detected in a subset of neurons in eachsegment, and this expression persists through embryonic and larval development. (Frasch et al., 1987)
Marker for
	aCC neuron RP2sib neuron dorsal acute muscle 1 | precursor cardioblast cell embryonic myoblast embryonic pericardial cell pCC neuron RP2 neuron somatic muscle | precursor | restricted pericaridal cell <of> dorsal vessel fpCC neuron
Subcellular Localization
CV Term	nucleus (MacDonald et al., 1986)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000606    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000606 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000606 expression level Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr    6146 embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (369) embryo 02-04hr  (6146) embryo 04-06hr  (715) embryo 06-08hr  (436) embryo 08-10hr  (344) embryo 10-12hr  (397) embryo 12-14hr  (281) embryo 14-16hr  (578) embryo 16-18hr  (285) embryo 18-20hr  (285) embryo 20-22hr  (182) embryo 22-24hr  (144) larva L1  (163) larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr  (6146) embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr    6146 embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr    6146 embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000606 expression level Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr    6146 embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (369) embryo 02-04hr  (6146) embryo 04-06hr  (715) embryo 06-08hr  (436) embryo 08-10hr  (344) embryo 10-12hr  (397) embryo 12-14hr  (281) embryo 14-16hr  (578) embryo 16-18hr  (285) embryo 18-20hr  (285) embryo 20-22hr  (182) embryo 22-24hr  (144) larva L1  (163) larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr  (6146) embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr    6146 embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    369 embryo 02-04hr    6146 embryo 04-06hr    715 embryo 06-08hr    436 embryo 08-10hr    344 embryo 10-12hr    397 embryo 12-14hr    281 embryo 14-16hr    578 embryo 16-18hr    285 embryo 18-20hr    285 embryo 20-22hr    182 embryo 22-24hr    144 larva L1    163 larva L2    51 larva L3 12hr old    37 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    11 white prepupae new    18 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    22 pupae 3d postWPP    4 pupae 4d postWPP    7 adult male 01day    5 adult male 05day    9 adult male 30day    9 adult female 01day    5 adult female 05day    4 adult female 30day    3 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000606    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000606 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000606 expression level Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000606 expression level Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    9.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    6.975 Larval Carcass no informative data Adult Head    7.2 Adult Eye    3.1 Adult Brain    8.4 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    9.9 Adult Midgut    7.8 Adult Hindgut    9.2 Adult Malpighian Tubules    6.8 Adult Fat Body no informative data Adult Salivary Gland    9.7 Adult Heart    4.4 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    7.8 Adult Ovary    5.7 Adult Testis    6.7 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.2   NA  Eye    3.1   NA  Brain    8.4   19.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    9.9   no informative data  Midgut    7.8   no informative data  Hindgut    9.2   9.1  Malpighian Tubules    6.8   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    9.7   NA  Heart    4.4   6.975  Trachea    NA   NA  VirginFemale Spermatheca    7.3   NA  InseminatedFemale Spermatheca    7.8   NA  Ovary    5.7   NA  Testis    6.7   NA  Male Accessory Gland    7.5   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000606 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2328-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal eve5 eve6 eve2387 eve2751 evehb.PP lethal (with Df(2R)X1) eve10-5 eve10-9 eve14-10 eve20-35 eve27-41 eve29-39 eve41-6 eve58-17 eve69-11 lethal | embryonic stage eveΔS2E lethal | embryonic stage, with Scer\GAL4h-1J3 eveScer\UAS.cBa lethal | embryonic stage, with Scer\GAL4how-24B eveScer\UAS.cBa lethal | embryonic stage, with Scer\GAL4l(3)31-1-31-1 eveScer\UAS.cBa lethal | embryonic stage | pair rule expression pattern | recessive eveunspecified lethal | heat sensitive evehs.PS lethal | recessive eve1 eve2R-226-8 eve3 eve10-9 eve14-10 eve111 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 eveGD1643 Other Phenotypes Allele cell polarity defective | gastrula stage eve3 cell polarity defective | gastrula stage | somatic clone, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 eveScer\UAS.cBa increased cell death | embryonic stage | recessive eve1 neuroanatomy defective eveunspecified eveΔRP2A neuroanatomy defective, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 neuroanatomy defective, with Scer\GAL4elav.PLu eveScer\UAS.cBa neuroanatomy defective, with Scer\GAL4Vap.P0201 eveScer\UAS.cBa wild-type eveE+L.8.4 evetPa Phenotype manifest in Allele abdominal 2 dorsal acute muscle 1 eve1 abdominal 3 dorsal acute muscle 1 eve1 abdominal 3 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 3 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 3 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 3 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 3 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 3 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 3 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 3 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 3 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 3 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 4 dorsal acute muscle 1 eve1 abdominal 4 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 4 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 4 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 4 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 4 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 4 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 4 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 4 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 4 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 4 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 5 dorsal acute muscle 1 eve1 abdominal 5 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 5 lateral transverse muscle 1 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 5 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 5 lateral transverse muscle 2 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 5 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 5 lateral transverse muscle 3 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 5 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 5 lateral transverse muscle 4 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 5 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal 5 ventral longitudinal muscle 3 & neuromuscular junction, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal 6 dorsal acute muscle 1 eve1 abdominal 7 dorsal acute muscle 1 eve1 abdominal anterior fascicle & abdominal segment 3 eve1 abdominal anterior fascicle & abdominal segment 4 eve1 abdominal anterior fascicle & abdominal segment 5 eve1 abdominal intersegmental nerve eve2xCQ.RC.T:Scer\GAL4 abdominal intersegmental nerve, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 abdominal posterior fascicle & abdominal segment 3, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal posterior fascicle & abdominal segment 3, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal posterior fascicle & abdominal segment 4, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal posterior fascicle & abdominal segment 4, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal posterior fascicle & abdominal segment 5, with Scer\GAL4elav-C155 eveScer\UAS.cBa abdominal posterior fascicle & abdominal segment 5, with Scer\GAL4ftz.ng eveScer\UAS.cBa abdominal segment 2 eve111-1464 eve4 evea.111-1464 abdominal segment 3 & somatic muscle eve1 abdominal segment 4 eve111-1464 eve4 evea.111-1464 abdominal segment 4 & somatic muscle eve1 abdominal segment 5 & somatic muscle eve1 abdominal segment 6 eve111-1464 eve4 evea.111-1464 abdominal segment 8 eve111-1464 eve4 evea.111-1464 abdominal segmental nerve, with Scer\GAL4elav.PLu eveScer\UAS.cBa aCC neuron eveΔRP2A adult hindgut primordium, with Scer\GAL4cad-em459 eveScer\UAS.cBa cardiac outflow muscle, with Scer\GAL4how-24B eveScer\UAS.cBa cardioblast, with Scer\GAL4how-24B eveScer\UAS.cBa cephalic furrow eve3 eveunspecified cuticle evehb.PP denticle | ectopic eve2R-226-8 denticle belt eve1 eve1.27 eve3 denticle belt, with Df(2R)eve, eve3 eveEGNΔLFK eveEGNAY eveEGNPA denticle belt, with Df(2R)eve, eveEGNAY eve3 denticle belt, with Df(2R)eve, eveEGNPA eve3 denticle belt, with Df(2R)eve, eveEGNΔLFK eve3 denticle belt, with eve3 eveEGNΔLFK eveEGNAY eveEGNPA denticle belt, with eve3/Df(2R)eve eveEGNΔLFK eveEGNAY eveEGNPA denticle belt, with eveEGNAY eve3 denticle belt, with eveEGNPA eve3 denticle belt, with eveEGNΔLFK eve3 denticle belt (with Df(2R)eve), with eveEGNAY eve3 denticle belt (with Df(2R)eve), with eveEGNPA eve3 denticle belt (with Df(2R)eve), with eveEGNΔLFK eve3 dMP2 neuron, with Scer\GAL4Vap.P0201 eveScer\UAS.cBa ectoderm | extended germ band stage eve1.27 embryo | pair rule expression pattern eve1 embryo | pair rule expression pattern, with Df(2R)eve, eve3 eveEGNΔLFK eveEGNAY eveEGNPA embryo | pair rule expression pattern, with Df(2R)eve, eveEGNAY eve3 embryo | pair rule expression pattern, with Df(2R)eve, eveEGNPA eve3 embryo | pair rule expression pattern, with Df(2R)eve, eveEGNΔLFK eve3 embryo | pair rule expression pattern, with eve3 eveEGNΔLFK eveEGNAY eveEGNPA embryo | pair rule expression pattern, with eve3/Df(2R)eve eveEGNΔLFK eveEGNAY eveEGNPA embryo | pair rule expression pattern, with eveEGNAY eve3 embryo | pair rule expression pattern, with eveEGNPA eve3 embryo | pair rule expression pattern, with eveEGNΔLFK eve3 embryo | pair rule expression pattern (with Df(2R)eve), with eveEGNAY eve3 embryo | pair rule expression pattern (with Df(2R)eve), with eveEGNPA eve3 embryo | pair rule expression pattern (with Df(2R)eve), with eveEGNΔLFK eve3 embryo | pair rule expression pattern | heat sensitive evehs.PS embryonic/first instar larval cuticle eve1 eve1.27 eve10-5 eve14-10 eve20-35 eve2R-226-8 eve58-11 embryonic/first instar larval cuticle, with Df(2R)eve, eve3 eveEGNΔLFK eveEGNAY eveEGNPA embryonic/first instar larval cuticle, with Df(2R)eve, eveEGNAY eve3 embryonic/first instar larval cuticle, with Df(2R)eve, eveEGNPA eve3 embryonic/first instar larval cuticle, with Df(2R)eve, eveEGNΔLFK eve3 embryonic/first instar larval cuticle, with eve3 eveEGNΔLFK eveEGNAY eveEGNPA embryonic/first instar larval cuticle, with eve3/Df(2R)eve eveEGNΔLFK eveEGNAY eveEGNPA embryonic/first instar larval cuticle, with eveEGNAY eve3 embryonic/first instar larval cuticle, with eveEGNPA eve3 embryonic/first instar larval cuticle, with eveEGNΔLFK eve3 embryonic/first instar larval cuticle (with Df(2R)eve), with eveEGNAY eve3 embryonic/first instar larval cuticle (with Df(2R)eve), with eveEGNPA eve3 embryonic/first instar larval cuticle (with Df(2R)eve), with eveEGNΔLFK eve3 embryonic/first instar larval cuticle | heat sensitive evehs.PS embryonic/larval fat body eve3 embryonic/larval heart anchoring cell, with Scer\GAL4how-24B eveScer\UAS.cBa embryonic/larval somatic muscle eve1 embryonic/larval visceral muscle eve1 embryonic heart anchoring cell primordium, with Scer\GAL4how-24B eveScer\UAS.cBa embryonic mesothoracic segment eve4 embryonic segment eve1 eve2R-226-8 embryonic segment | heat sensitive evehs.PS embryonic segment | pair rule expression pattern eve1 eveunspecified epidermis & larval midgut & embryo eveunspecified extended germ band embryo eve3 evehs.PS germ band | gastrula stage | somatic clone, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 eveScer\UAS.cBa heart primordium, with Scer\GAL4how-24B eveScer\UAS.cBa intersegmental nerve eve2xCQ.RC.T:Scer\GAL4 eveunspecified intersegmental nerve, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 intersegmental nerve, with Scer\GAL4elav.PLu eveScer\UAS.cBa larval brain & neuroblast (with eve1) eve5 larval brain & neuroblast (with eve5) eve1 mesothoracic intersegmental nerve eve2xCQ.RC.T:Scer\GAL4 mesothoracic intersegmental nerve, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 metathoracic intersegmental nerve eve2xCQ.RC.T:Scer\GAL4 metathoracic intersegmental nerve, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 midgut constriction eveunspecified mitotic domain 2 eve3 parasegment eve1 eve3 eveE+L.8.4 parasegment 1 | precursor eve3 parasegment 3 eve1 parasegment 3 | heat sensitive evehs.PS parasegment 4 eve1 parasegment 4 | heat sensitive evehs.PS parasegment 5 eve1 parasegment 5 | heat sensitive evehs.PS parasegment 6 eve1 parasegment 6 | heat sensitive evehs.PS pericardial cell eve1 presumptive embryonic/larval central nervous system, with Scer\GAL4elav.PLu eveScer\UAS.cBa presumptive embryonic/larval nervous system eve1 prothoracic intersegmental nerve eve2xCQ.RC.T:Scer\GAL4 prothoracic intersegmental nerve, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 RP2 neuron eveΔRP2A eve1 RP2 neuron, with eveunspecified eveΔRP2A RP2 neuron, with eveΔRP2A eveunspecified U neuron, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4 U neuron | embryonic stage 13 eve2xCQ.RC.T:Scer\GAL4 VUM neuron, with RdlScer\UAS.cSa eve2xCQ.RC.T:Scer\GAL4
Classical Alleles ( 28 )
For All Classical Alleles Show
Allele of eve Class Mutagen Stocks Known lesion eve1 hypomorphic allele - genetic evidence ethyl methanesulfonate 12 Yes eve15H6a 5 -- eve3 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes eve5 ethyl methanesulfonate 2 Yes eve4 hypomorphic allele - genetic evidence X ray 1 Yes eve1.27 amorphic allele - genetic evidence, loss of function allele 0 -- eve10-5 hypomorphic allele - genetic evidence ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve10-9 ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve111 ethyl methanesulfonate 0 -- eve14-10 hypomorphic allele - genetic evidence ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve20-35 hypomorphic allele - genetic evidence ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve2387 ethyl methanesulfonate 0 -- eve27-41 ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve2751 ethyl methanesulfonate 0 Yes eve29-39 ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes eve2R-226-8 ethyl methanesulfonate 0 -- eve41-6 ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve58-11 loss of function allele 0 -- eve58-17 ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve69-11 ethyl methanesulfonate diepoxybutane gamma ray 0 -- eve6 ethyl methanesulfonate 0 -- eveAf-S natural population 0 -- eveFl-S natural population 0 -- eveOR-RC natural population 0 -- eveunspecified 0 -- eveWa-F natural population 0 -- eveZM56 natural population 0 --
Alleles Carried on Transgenic Constructs ( 105 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eve Class Mutagen Stocks Known lesion eveGD1643 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eveHMS01312 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eveJF03161 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eveT:Avic\GFP-EGFP in vitro construct - coding region fusion 1 Yes eve-4.8.+8.4 in vitro construct - genomic fragment 0 Yes eve-4.8.+9.2 in vitro construct - genomic fragment 0 Yes eve111-1464 in vitro construct - RNAi in vitro construct 0 Yes eve2xCQ.RC.T:Scer\GAL4 in vitro construct - regulatory fusion 0 Yes eve2xRP2+.RC.T:Scer\GAL4 in vitro construct - regulatory fusion 0 Yes evea.111-1464 in vitro construct - RNAi in vitro construct 0 Yes eveAB.T:Ivir\HA1,T:Hsim\VP16 in vitro construct - coding region fusion 0 Yes eveAB.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABC.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABC1D.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABC2D.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABC2D2.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCD.T:Ivir\HA1,T:Hsim\VP16 in vitro construct - coding region fusion 0 Yes eveABCD.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCD1.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCD2.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCDE.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveAbCDEF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCDF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCE.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCEF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABCff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveABD.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABDE.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABDEF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABDF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABE.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABEF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveABFS1.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABFS2.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveABFS3.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveAct5C.PB in vitro construct - regulatory fusion 0 Yes eveAct5C.PH in vitro construct - regulatory fusion 0 Yes eveAff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveB.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveBCD.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveBCDEF.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes eveBCDEF.T:Scer\GAL4 in vitro construct - coding region fusion 0 Yes eveBCDff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveBCff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveBff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveC.T:Scer\GAL4,T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes evecBa in vitro construct 0 -- eveCD.T:Scer\GAL4 in vitro construct - coding region fusion 0 Yes eveCDEF.T:Scer\GAL4 in vitro construct - coding region fusion 0 Yes eveCDff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveCff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveDere\eve.S2E in vitro construct - regulatory fusion 0 Yes eveDff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveDpse\eve.S2E in vitro construct - regulatory fusion 0 Yes evedsRNA.cMa in vitro construct - RNAi 0 Yes evedsRNA.cWa in vitro construct - RNAi 0 Yes evedsRNA.si.cWa in vitro construct - RNAi 0 Yes eveDyak\eve.S2E in vitro construct - regulatory fusion 0 Yes eveE+L.8.4 in vitro construct - regulatory fusion in vitro construct - genomic fragment 0 Yes eveE+L.9.2 in vitro construct - regulatory fusion 0 Yes eveE+L in vitro construct - genomic fragment 0 Yes eveE in vitro construct - genomic fragment 0 Yes eveEGN86.T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes eveEGN86 in vitro construct - genomic fragment 0 Yes eveEGN92.Δ46 in vitro construct - deletion 0 Yes eveEGNAY in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct 0 Yes eveEGNHA in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes eveEGNPA in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement in vitro construct 0 Yes eveEGNΔLFK in vitro construct - deletion 0 Yes eveEL.RC.T:Scer\GAL4 in vitro construct - regulatory fusion 0 Yes eveeme.86T in vitro construct - deletion 0 Yes eveemeΔES in vitro construct - deletion 0 Yes eveemeΔNS in vitro construct - deletion 0 Yes eveEn-H.T:Zzzz\FLAG,T:en-Rep in vitro construct - coding region fusion 0 Yes eveeve.S2E in vitro construct - regulatory fusion 0 Yes eveeveff.Act5C.T:Mmmm\Sp1 in vitro construct - coding region fusion 0 Yes evefl.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes eveFS1.T:Scer\GAL4 in vitro construct - coding region fusion 0 Yes eveH-En.T:Zzzz\FLAG,T:en-Rep in vitro construct - coding region fusion 0 Yes eveH.T:Zzzz\FLAG in vitro construct - deletion 0 Yes evehb.PP in vitro construct - regulatory fusion 0 Yes evehs.PS in vitro construct - regulatory fusion 0 Yes eveJ23ff.Act5C.T:Mmmm\Sp1 in vitro construct - deletion 0 Yes eveKK107879 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes eveL in vitro construct - genomic fragment 0 Yes eveR.T:Scer\GAL4,T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes eveRC.T:Scer\GAL4,T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes eveRVΔSac in vitro construct - deletion 0 Yes eveRΔA.T:Zzzz\FLAG in vitro construct - deletion 0 Yes eveS2E.0 in vitro construct - deletion in vitro construct 0 Yes eveScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes evetCH322-103K22 in vitro construct - genomic fragment 0 Yes evetPa in vitro construct - genomic fragment 0 Yes eveΔEL in vitro construct - deletion 0 Yes eveΔN.T:Zzzz\FLAG in vitro construct - deletion 0 Yes eveΔR.T:Zzzz\FLAG in vitro construct - deletion 0 Yes eveΔRC.T:Zzzz\FLAG in vitro construct - deletion 0 Yes eveΔRP2A in vitro construct - deletion 0 Yes eveΔRP2B in vitro construct - deletion 0 Yes eveΔRP2C in vitro construct - deletion 0 Yes eveΔS2E in vitro construct - deletion in vitro construct 0 Yes eveΔUCQ in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Ab(2R)89-22 (Goldstein et al., 2001) Df(2R)71-81 (Goldstein et al., 2001) Df(2R)520 (O'Brien et al., 1994) Df(2R)521 (O'Brien et al., 1994) Df(2R)B5 (O'Brien et al., 1994, Ranganayakulu et al., 1995) Df(2R)eve (Goldstein et al., 2001, Tearle and Nusslein-Volhard, 1987, Goto et al., 1989, Morrissey et al., 1991, Smith et al., 1993, O'Brien et al., 1994, Harbecke and Lengyel, 1995, Ranganayakulu et al., 1995, Fujioka et al., 1995, Klingler et al., 1996) Df(2R)G44 (Muller et al., 1999) Df(2R)X1 (Goldstein et al., 2001, O'Brien et al., 1994, Bour et al., 1995, Ranganayakulu et al., 1995) Df(2R)X3 (Goldstein et al., 2001, O'Brien et al., 1994, Bour et al., 1995, Ranganayakulu et al., 1995)
Not disrupted in	Ab(2R)55-20 (Goldstein et al., 2001) Df(2R)61-25 (Goldstein et al., 2001) Df(2R)64-10 (Goldstein et al., 2001) Df(2R)520 (Goldstein et al., 2001, Bour et al., 1995) Df(2R)P402 (Ranganayakulu et al., 1995) Df(2R)stan2 (Goldstein et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
reporter construct	Name Expression Data P{1.2delta1.1-lacZ} No P{1.5-8.4.eve-lacZ} No P{1.7delta.7-lacZ} No P{1.55delta1.3-lacZ} No P{1.55delta.7-lacZ} No P{1.55-eve-lacZ} No P{2EΔ3'} No P{2EΔ5'} No P{2EΔ12} No P{2EΔ23} No P{2EΔ34} No P{2NE} No P{2SED} No P{2SEP1} No P{2SEP2} No P{2SEP3} No P{2SNF1} No P{2SNF2} No P{2x110bpVRE.mAT1} No P{2x110bpVRE.mAT2.I} No P{2x110bpVRE.mAT12} No P{2x110bpVRE} No P{2x180bpVRE} No P{2xVRE200.5.MSE.eve/lacZ} No P{2xVRE200.10.MSE.eve/lacZ} No P{2xVRE200.mAT1.mAT3.MSE.eve/lacZ} No P{2xVRE200.mAT1.MSE.eve/lacZ} No P{2xVRE200.mAT2.MSE.eve/lacZ} No P{2xVRE200.MSE.eve/lacZ} No P{3.stripe2.5-NEE-lacZ} No P{4.8-12.0.eve-lacZ} No P{4E200Aeve-lacZ} No P{4EΔ23} No P{4x50bpVRE} No P{4x70bpVRE} No P{5.stripe2.3-NEE-lacZ} No P{6E100(MAS)} No P{7x37bpVRE} No P{32Bsu} No P{32ΔBsu} No P{41ΔSac} No P{70eve-hsp70} No P{180bpVRE.mAT} No P{180bpVRE.mGC} No P{180bpVRE} No P{200eve-hsp70} No P{260eve-hsp70} No P{350bpVRE} No P{370eve-hsp70} No P{430bpVRE} No P{500eve-hsp70} No P{1600eve-hsp70} No P{'a'.'b'.ΔB1} No P{'a'.ΔB1} No P{'a'.ΔH3} No P{'a'} No P{'b'.ΔB1} No P{Ady43A.217.eve-lacZ} No P{brk.357.eve-lacZ} No P{C3DZ} No P{CAT-eve.eve-lacZ.IAB5} No P{CAT-eve.eveΔGAGA-lacZ.IAB5} No P{CAT-eve.IAB5.eve-lacZ} No P{CAT-eve.IAB5.eveΔGAGA-lacZ} No P{CAT-eve.TATA.w-lacZ.IAB5} No P{CAT-eve.w/eve-lacZ.IAB5} No P{CAT-eve.w/eveΔGAGA-lacZ.IAB5} No P{CAT-w.IAB5.eve-lacZ} No P{CAT-w.IAB5.eveΔGAGA-lacZ} No P{CG12444.75.eve-lacZ} No P{CQ.EL.UAS-lacZ} No P{E3-MAR-2PE} No P{E100(MAS)} No P{eB3.eB4.eB5.ΔB1} No P{eB3.eB4.eB5.ΔH3} No P{eB3.eB4.eB5} No P{eB3} No P{eB4.eB5} No P{EL1} No P{ET-L} No P{eve-2sna} No P{eve-3sna} No P{eve-4sna} No P{eve5'A} No P{eve5'B} No P{eve5'E} No P{eve5'G} No P{eve5'H} No P{eve5'I} No P{eve/lacZ} No P{eve.1.7delta1.1-lacZ} No P{eve.2.eve.3+7-lacZ} No P{eve'-tau/lacZ} No P{eve-CAT.eve/w-lacZ.NEE.IAB5} No P{eve-CAT.ftz-lacZ.AE1} No P{eve-CAT.w/GAGA/TATA-lacZ.IAB5} No P{eve-CAT.w/TATA/GAGA-lacZ.IAB5} No P{eve-CAT.w/TATA-lacZ.IAB5} No P{eve-CAT.w/TATA-lacZ.NEE.IAB5} No P{eve-CAT.w-lacZ.IAB5} No P{eve-lacZ0.04} No P{eve-lacZ0.4} No P{eve-lacZ1.7} No P{eve-lacZ3.0} No P{eve-lacZ4.7} No P{eve-lacZ5.2} No P{eve-lacZ5.4} No P{eve-lacZ5.5} No P{eve-lacZ5.9} No P{eve-lacZ6.3} No P{eve-lacZ6.3+1.2} No P{eve-lacZ8.0} No P{eve-lacZ.1-546} No P{eve-lacZ.1-735} No P{eve-lacZ.1-890} No P{eve-lacZ.2GTTT4mut} No P{eve-lacZ.2ΔGTTT4} No P{eve-lacZ.3+7.m6K} No P{eve-lacZ.-4.8-11.0} No P{eve-lacZ.-4.8-22.0} No P{eve-lacZ.-4.8+8.4} No P{eve-lacZ.4.96-7.36} No P{eve-lacZ.-5.5-7.0} No P{eve-lacZ.-5.5-7.4} No P{eve-lacZ.-5.5-11.0} No P{eve-lacZ.-5.6-7.4} No P{eve-lacZ.-7.4+8.4} No P{eve-lacZ.-7.8} No P{eve-lacZ.-13.7} No P{eve-lacZ.-17.2-27.6} No P{eve-lacZ.-18.4-25.0} No P{eve-lacZ.+1.5+3.2} No P{eve-lacZ.+1.5+4.8} No P{eve-lacZ.+1.5+6.6} No P{eve-lacZ.+1.5+8.4} No P{eve-lacZ.+4.8+12.0} No P{eve-lacZ.+12.0+17.5} No P{eve-lacZ.A} No P{eve-lacZ.B} No P{eve-lacZ.C3DZ.enh} No P{eve-lacZ.C} No P{eve-lacZ.D} No P{eve-lacZ.E} No P{eve-lacZ.EB429} No P{eve-lacZ.EME0.9SS} No P{eve-lacZ.eme1} No P{eve-lacZ.eme2.Lb*} No P{eve-lacZ.eme2} No P{eve-lacZ.eme3} No P{eve-lacZ.eme4} No P{eve-lacZ.eme900} No P{eve-lacZ.EME.A} No P{eve-lacZ.EME.B3'.HD.Zfh1} No P{eve-lacZ.EME.B3'.MedDEF} No P{eve-lacZ.EME.B3'.MedEF} No P{eve-lacZ.EME.B3'.PanC-F} No P{eve-lacZ.EME.B3'.TinB} No P{eve-lacZ.EME.B3'.TinBCD} No P{eve-lacZ.EME.B3'.TinBD} No P{eve-lacZ.EME.B3'} No P{eve-lacZ.EME.B5'} No P{eve-lacZ.EME.B.FD} No P{eve-lacZ.EME.B.PanB} No P{eve-lacZ.EME.B.PanBE} No P{eve-lacZ.EME.B.PanE} No P{eve-lacZ.EME.B.TinBD} No P{eve-lacZ.EME.B.TinD} No P{eve-lacZ.EME.B} No P{eve-lacZ.EME.B*.PanA-E} No P{eve-lacZ.EME.B*.PanA-F} No P{eve-lacZ.EME.C} No P{eve-lacZ.EME.MHE} No P{eve-lacZ.emeA.dTCF*.Tin12*} No P{eve-lacZ.emeA.dTCF*} No P{eve-lacZ.emeA.tin3*} No P{eve-lacZ.emeA.tin12*} No P{eve-lacZ.emeA.tin123*} No P{eve-lacZ.emeA} No P{eve-lacZ.F1} No P{eve-lacZ.F2} No P{eve-lacZ.F3} No P{eve-lacZ.F4} No P{eve-lacZ.F5} No P{eve-lacZ.F6} No P{eve-lacZ.F7} No P{eve-lacZ.F8} No P{eve-lacZ.F9} No P{eve-lacZ.F10} No P{eve-lacZ.F11} No P{eve-lacZ.F12} No P{eve-lacZ.F13} No P{eve-lacZ.F14} No P{eve-lacZ.F15} No P{eve-lacZ.F16} No P{eve-lacZ.F17} No P{eve-lacZ.F18} No P{eve-lacZ.F19} No P{eve-lacZ.F20} No P{eve-lacZ.F21} No P{eve-lacZ.F22} No P{eve-lacZ.F23} No P{eve-lacZ.F24} No P{eve-lacZ.F25} No P{eve-lacZ.F26} No P{eve-lacZ.F27} No P{eve-lacZ.F28} No P{eve-lacZ.F29} No P{eve-lacZ.F30} No P{eve-lacZ.F31} No P{eve-lacZ.F32} No P{eve-lacZ.F33} No P{eve-lacZ.F34} No P{eve-lacZ.F35} No P{eve-lacZ.F36} No P{eve-lacZ.F37} No P{eve-lacZ.F38} No P{eve-lacZ.F39} No P{eve-lacZ.F40} No P{eve-lacZ.HDHD} No P{eve-lacZ.MHE.Amut} No P{eve-lacZ.MHE.dTCF.ETS3} No P{eve-lacZ.MHE.dTCF.twi1} No P{eve-lacZ.MHE.dTCF} No P{eve-lacZ.MHE.ETS1-4} No P{eve-lacZ.MHE.ETS1} No P{eve-lacZ.MHE.ETS3} No P{eve-lacZ.MHE.Mad4.5.6} No P{eve-lacZ.MHE.tin1-4} No P{eve-lacZ.MHE.tin1} No P{eve-lacZ.MHE.twi1.2} No P{eve-lacZ.MHE.twi1} No P{eve-lacZ.MHE} No P{eve-lacZ.MSE2.D1} No P{eve-lacZ.MSE2.D2} No P{eve-lacZ.MSE2.D3} No P{eve-lacZ.MSE2.D4} No P{eve-lacZ.MSE2.D5} No P{eve-lacZ.MSE2.wt} No P{eve-lacZ.P} No P{eve-lacZ.PB6} No P{eve-lacZ.PH0} No P{eve-lacZ.PTE+1} No P{eve-lacZ.PTE+2} No P{eve-lacZ.PTE+5} No P{eve-lacZ.PTE+10} No P{eve-lacZ.PTEinv} No P{eve-lacZ.S1} No P{eve-lacZ.S1S2} No P{eve-lacZ.S2} No P{eve-lacZ.st2.UAS.st3} No P{eve-lacZ.XPRD} No P{eve-lacZ.Δ235} No P{eve-lacZ.Δ546} No P{eve-lacZ.ΔPTE} No P{eve-lacZ#1} No P{eve-lacZ#2} No P{eve-lacZ#3} No P{eve-lacZ#4} No P{eve-lacZ#5} No P{eve-lacZ#6} No P{eve-lacZ#7} No P{eve-lacZ#8} No P{evestripe2-2xUAS-lacZ} No P{evestripe2-3s-lacZ} No P{evestripe2-lacZ} No P{eve-UAS-eve-lacZ} No P{eveΔA} No P{eveΔB} No P{eveΔC} No P{eveΔD} No P{eveΔE} No P{eveΔF} No P{eveΔG} No P{eveΔH} No P{eveΔI} No P{eveΔJ} No P{eveΔK} No P{EΔ3'} No P{EΔ5'} No P{EΔ12} No P{EΔ23} No P{EΔ34} No P{HZ2E200A} No P{HZ4E200W} No P{lacZeve.dist51:twi:prox54} No P{lacZeve.dist51} No P{lacZeve.dist51prox54} No P{lacZeve.prox54} No P{lacZeve.PΔbcd1-kr3,bcd2} No P{lacZeve.PΔbcd1-kr3} No P{lacZeve.PΔgt1} No P{lacZeve.PΔgt2,gt3} No P{lacZeve.PΔhb3} No P{lacZeve.PΔkr1,kr2,kr4,kr6} No P{lacZeve.PΔkr1--kr6} No P{lacZeve.st2.UAS.339.st3} No P{lacZeve.st3.rho.UAS} No P{lacZzen/eve.600bpVRE} No P{lacZzen/eve.mVR/MSE} No P{lacZzen/eve.tVR/MSE} No P{L-lacZ} No P{Lm} No P{LmLd} No P{m1-p2.eve.Dpse\eve.2.eve.3+7-lacZ} No P{MSE.eve/lacZ.rVRE} No P{MSE.eve/lacZ.VRE} No P{MSE-lacZ} No P{NE} No P{p1-m2.eve.Dpse\eve.2.eve.3+7-lacZ} No P{Phm.272.eve-lacZ} No P{PstBsu} No P{PstΔBsu} No P{PstΔSac} No P{RVBsu} No P{RVSac} No P{RVΔ41S} No P{RVΔPS} No P{RVΔSac} No P{RΔMAS} No P{SED} No P{SEP1} No P{SEP2} No P{SEP3} No P{SNF1} No P{SNF2} No P{sog.263.eve-lacZ} No P{St2.VRE600.St3.eve/lacZ} No P{st2-UAS-st3-lacZ} No P{st3.ind.111-eve-lacZ} No P{st3.ind.155-eve-lacZ} No P{st3.ind.267-eve-lacZ} No P{st3.ind.306-eve-lacZ} No P{st3.ind.484-eve-lacZ} No P{st3.ind.543-eve-lacZ} No P{st3.ind.774-eve-lacZ} No P{St3.VRE600.St2.eve/lacZ} No P{st3-ind1.4-eve-lacZ} No P{st3-ind.422.-eve-lacZ} No P{st3-ind.985.-eve-lacZ} No P{St.2-su(Hw)-St.3} No P{St.3-scs0.9-St.2} No P{St.3-scs1.8-St.2} No P{St.3-su(Hw)-St.2} No P{St.3-twi400-St.2} No P{stripe3-NEE-lacZ} No P{VR600-su(Hw)-St.2} No P{w-CAT.eve/w-lacZ.IAB5.su(Hw)} No P{w-CAT.eve/w-lacZ.IAB5} No P{w-CAT.eve-lacZ.IAB5} No P{w-w.eve-lacZ.AE1.su(Hw)} No P{w-w.eve-lacZ.AE1} No P{w-w.w-CAT.eve-lacZ.NEE.IAB5} No P{zen:eve-lacZ.mutII} No P{zen:eve-lacZ.mutIII} No P{zen:eve-lacZ.mutIV} No P{ΔB1.G1.G2.G3} No P{ΔB1} No P{ΔG1.G2.G3} No P{ΔG1.G3} No P{ΔG2} No P{ΔH3} No P{ΔSAMS} No
UAS construct	Name Expression Data P{GD1643} NA P{KK107879} NA P{TRiP.HMS01312} NA P{TRiP.JF03161} NA P{UAS-eve.B} NA
heat-shock construct	Name Expression Data P{hsp70-eve19} NA
characterization construct	Name Expression Data P{CQ2-GAL4} NA P{Dere\eve.S2E-eve} NA P{Dpse\eve.S2E-eve} NA P{Dyak\eve.S2E-eve} NA P{E3-ftz-distal-PE} NA P{E+L-eve.8.4.G} NA P{E+L-eve.9.2.G} NA P{E+L-eve} NA P{E-eve} NA P{EGN86} NA P{EGN92.Δ46} NA P{EGNAY} NA P{EGNHA} NA P{EGNPA} NA P{EGNΔLFK} NA P{eve.-4.8.+8.4} NA P{eve.-4.8.+9.2} NA P{eve.S2E-eve} NA P{eve.st3-GAL4.S} NA P{eve.ΔEL} NA P{eve.ΔRP2A} NA P{eve.ΔRP2B} NA P{eve.ΔRP2C} NA P{eve.ΔUCQ} NA P{eve+.86T} NA P{eve+.emeΔES} NA P{eve+.emeΔNS} NA P{eveEGN86.T:Zzzz\FLAG} NA P{eveEn-H.T:Zzzz\FLAG} NA P{eveH.T:Zzzz\FLAG} NA P{eveH-En.T:Zzzz\FLAG} NA P{eveRΔA.T:Zzzz\FLAG} NA P{eveS2E.0} NA P{evetPa} NA P{eveΔN.T:Zzzz\FLAG} NA P{eveΔR.T:Zzzz\FLAG} NA P{eveΔRC.T:Zzzz\FLAG} NA P{eveΔS2E} NA P{eve-FLP1.R} NA P{eve-GAL4.eme} NA P{eve-GAL4.RKK} NA P{eve-GAL4.RRa} NA P{hb-eve::h.J} NA P{hb-eve::h.K} NA P{hb-eve::h.Δ} NA P{hb-eve} NA P{hs-eve::h.J} NA P{L-eve} NA P{Meh1} NA P{RN2-GAL4} NA P{RP2.EL.UAS-GFP} NA P{RVΔSac-eve} NA PBac{CH322-103K22} NA PBac{eve-EGFP.S} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity inferred from direct assay (Bouchard et al., 2000, Yin et al., 1997, Han et al., 2002) sequence-specific DNA binding transcription factor activity inferred from direct assay (Li et al., 2008)
Biological Process
CV term Evidence References
cephalic furrow formation inferred from mutant phenotype (Vincent et al., 1997) germ-band extension inferred from mutant phenotype (Zallen and Wieschaus, 2004) motor axon guidance inferred from mutant phenotype (Labrador et al., 2005) negative regulation of cardioblast cell fate specification inferred from mutant phenotype (Jagla et al., 2002) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Bouchard et al., 2000) inferred from mutant phenotype (Yin et al., 1997) positive regulation of transcription from RNA polymerase II promoter inferred from expression pattern (Han et al., 2002) regulation of axonogenesis inferred from mutant phenotype (Fujioka et al., 2003)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Han et al., 2002)
Terms Based on Predictions or Assertions ( 16 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Biological Process
CV term Evidence References
anterior/posterior axis specification, embryo non-traceable author statement (Taylor, 2002) blastoderm segmentation traceable author statement (Canon and Banerjee, 2000) cell fate commitment non-traceable author statement (Cripps and Olson, 2002) cell fate determination non-traceable author statement (Skeath and Thor, 2003) central nervous system development non-traceable author statement (Skeath and Thor, 2003) germ-band extension traceable author statement (Baum, 2004) heart development non-traceable author statement (Cripps and Olson, 2002) muscle organ development traceable author statement (Dworak and Sink, 2002) nervous system development non-traceable author statement (Swiss-Prot Project Members, 1988.1.1) periodic partitioning by pair rule gene non-traceable author statement (Swiss-Prot Project Members, 1988.1.1, Davis and Patel, 2003) traceable author statement (Davies and Patel, 1999, Peel, 2004) posterior head segmentation traceable author statement (Peel, 2004) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-) trunk segmentation traceable author statement (Peel, 2004)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1988.1.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eve allele Gene References eve1.27 egl (Bullock et al., 2004) eve1 ftz (Hughes and Krause, 2001) gro (Kobayashi et al., 2001) Gug (Zhang et al., 2002) trol (Park et al., 1998) eve2 Gug (Zhang et al., 2002) eve3 Gug (Zhang et al., 2002) trol (Park et al., 1998, Park et al., 2001) eve4 Gug (Zhang et al., 2002) trol (Park et al., 1998) eve5 trol (Park and Datta, 1998, Park et al., 1998) eve6 trol (Park and Datta, 1998) eve10-5 trol (Park et al., 2001) eve20-35 trol (Park et al., 2001) eve58-11 trol (Park et al., 2001) evehs.PS ftz (Hughes and Krause, 2001) eveScer\UAS.cBa beat-Ia (Landgraf et al., 1999) zfh1 (Su et al., 1999) evetPa trol (Park et al., 1998) unspecified l(2)41Ae (Duffy et al., 1996) Nipped-A (Duffy et al., 1996) RpII140 (Parkhurst and Ish-Horowicz, 1991) RpL36 (Duffy et al., 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61867 DroID - A comprehensive database of gene and protein interactions. • FBgn0000606 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36039
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11297 Dere\eve Dgri\eve Dmoj\GI20020 Dper\GL16768 Dpse\eve Dsec\GM21172 Dvir\eve Dwil\eve Dyak\eve
Curated drosophilid orthologs	Dana\eve (Ludwig et al., 2000) Dere\eve (Ludwig et al., 1998) Dgri\eve   Dhyd\eve   Dlit\eve   Dmau\eve   Dmir\eve   Dore\eve (Ludwig et al., 2000) Dpic\eve   Dpse\eve (Schaeffer and Anderson, 1997) Dsec\eve (Ludwig et al., 2000) Dsim\eve   Dtak\eve (Ludwig et al., 2000) Dtei\eve (Ludwig et al., 2000) Dvir\eve (Ludwig et al., 2000) Dwil\eve   Dyak\eve
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007369-PA Aedes aegypti (mosquito) AGAP010279-PA Anopheles gambiae (mosquito) XP_001120749.1 Apis mellifera (honey bee) XP_001947366.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000027866 Bos taurus (bovine) CE42059 Caenorhabditis elegans (worm) ENSCAFP00000004404 Canis familiaris (dog) JA01226 Caenorhabditis japonica (nematode) CPIJ013533 Culex pipens (mosquito) RP43575 Caenorhabditis remanei (nematode) 104183 Daphnia pulex (daphnia) ENSECAP00000011978 Equus caballus (horse) ENSGACP00000006040 Gymnopilus aculeatus (mushroom) ENSGALP00000037900 Gallus gallus (chicken) ENSP00000222761 Homo sapiens (human) ISCW018031-PA Ixodes scapularis (deer tick) ENSMMUP00000017697 Macaca mulatta (rhesus monkey) ENSMUSP00000107621 Mus musculus (house mouse) ENSOANP00000002362 Ornithorynchus anatinus (platypus) ENSORLP00000006363 Oryzias latipes (japanese killifish) PHUM007829-PA Pediculus humanus (human body louse) ENSPPYP00000019836 Pongo pygmaeus (orangutan) ENSPTRP00000032506 Pan troglodytes (chimpanzee) ENSRNOP00000010605 Rattus norvegicus (norway rat) ENSTNIP00000004184 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044950 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15848 LH15244 ISCW001025 FBgn0236181 FBgn0024766 FBgn0064268 FBgn0040404 FBgn0176053 FBgn0020474 FBgn0154372 FBgn0142756 FBgn0015087 FBgn0024802 FBgn0088337 CPIJ013533 BGIBMGA009710 ACYPI005576 ACYPI003551 GB10623 AGAP010279 AAEL007369 PB23087 PHUM236390 GLEAN_09469
Stocks & Reagents
Stocks Listed in FlyBase ( 27 )
Bloomington	4084 eve5/SM6a 5344 eve1/CyO; P{ftz/lacC}1 299 b1 pr1 eve3/CyO 28734 y1 v1; P{TRiP.JF03161}attP2 30871 y1 w*; PBac{eve-EGFP.S}VK00033 3135 slp11 b1 eve15H6a/SM6a 1814 al1 wgl-12 eve15H6a/SM6a
Kyoto	107577 eve5/SM6a 105845 b1 pr1 eve3/CyO 106518 al1 wgl-12 eve15H6a/SM6a
VDRC	v9285 w1118 P{GD1643}v9285 v9284 w1118; P{GD1643}v9284
	More stocks available...
Genomic Clones ( 2 )
	BACR01L01 BACR06J01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	MIP30861 RT01063 RT01163
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000606 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36039
Antibody Information
	monoclonal antibody (Bhat and Apsel, 2004) polyclonal (MacDonald et al., 1986, Frasch et al., 1987) polyclonal antibody (Bhat and Apsel, 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: eve l(2)46Ce (Datta, 1998.3.10) Source for merge of: eve l(2)46CFh l(2)46CFj l(2)46CFp (Goldstein, 2004.3.15) Source for merge of: eve l(2)46Cg (Goldstein, 2001.6.5)
Additional comments
Other Comments
	eve functions in an eve --> grn --> zfh1 regulatory cascade within the aCC motoneuron, along with suppressing exex expression. By contrast, there is only partial cross-regulation between eve, grn, zfh1 and exex in the RP2 motoneuron. (Garces and Thor, 2006) eve acting as a repressor, regulates axonal projections. (Fujioka et al., 2003) eve represses exex in a gro-dependent fashion. Cross-repressive interactions between exex and eve delimit exex expression to ventral and lateral motor neurons and eve expression to dorsal motor neurons. (Broihier and Skeath, 2002) Cross-repressive interactions between the "identity genes" lbe, lbl, Dr and eve are essential for the specification of cardiac and muscular fates in the developing embryo. (Jagla et al., 2002) Parasegment widths are defined early in the embryo by the relative levels of ftz and eve proteins at stripe junctions. (Hughes and Krause, 2001) ftz and eve are expressed in the pole cells of nos- embryos. (Deshpande et al., 1999) The 7.7kb 3' regulatory region of eve contains both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients. (Fujioka et al., 1999) eve and tup constitute a bimodal switch regulating axonal growth and directing motor axons to ventral (tup) or dorsal (eve) regions of the muscle field during embryogenesis. (Landgraf et al., 1999) eve is needed for the correct differentiation of the eve-expressing subset of pericardial cells, possibly as a direct target of zfh1. (Su et al., 1999) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) The mechanism of transcriptional repression by eve protein involves a direct interaction with the Tbp protein. (Li and Manley, 1998) In vitro DNA-binding studies reveal pros reduces eve regulatory region binding to DNA to very low levels. (Hassan et al., 1997) prd regulates late even skipped expression through a composite binding site for the paired domain and the homeodomain. Mutagenesis of either binding site leads to significant reduction in the activity of the late element, indicating that both domains are required for regulation. (Fujioka et al., 1996) Despite the absence of a syncytium in C.floridanum embryos monoclonal antibodies to en, Ubx and abd-A demonstrate their cognate proteins are expressed in a conserved pattern in the post-gastrulation stages of development. The expression of the eve cognate protein is not completely conserved ad lacks a pair rule phase to its expression. (Grbic et al., 1996) hop may activate Stat92E to regulate transcription of target genes such as eve. (Hou et al., 1996) An injection of a monoclonal antibody against the eve homeodomain, in conjunction with chromophore-assisted laser inactivation (CALI), precisely phenocopies the eve mutant phenotype. (Schroder et al., 1996) The stripe 3+7 enhancer is about 500bp in length and maps about 3.3kb upstream of the transcription start site. The enhancer is regulated by one or more ubiquitously distributed activators. (Small et al., 1996) eve protein has broad DNA recognition properties in vitro that are likely to be important determinants of its distribution on DNA in vivo. (Walter and Biggin, 1996) Two binding sites for Stat92E protein have been identified in the eve stripe 3 enhancer region. (Yan et al., 1996) In vitro transcription experiments suggest that eve protein represses transcription by inhibiting binding of TFIID to the promoter. (Austin and Biggin, 1995) The gt transcriptional repressor defines the anterior border of stripe 2 of eve. A single gt binding site maps 50bp from the nearest activator site in the eve stripe 2 enhancer. (Barolo and Levine, 1995) The full length and 0.9kb fragment of scs and a 430bp fragment from gypsy carrying 12 su(Hw) binding sites (gypsy\su(Hw)BR430) can block the interaction of defined eve stripe enhancers when positioned between the enhancer and target promoter. (Cai and Levine, 1995) cas, eve, unpg and ac are expressed in specific neuroblast sublineages. Expression studies using pbl and stg mutants suggest that neuroblasts have an intrinsic gene regulatory hierarchy controlling unpg and ac expression but that cell cycle- or cytokinesis-dependent mechanisms are required for cas and eve CNS expression. (Cui and Doe, 1995) Early and late eve expression have distinct roles in regulating downstream genes. Early expression is required for the activation of both even and odd numbered en stripes and late eve stripes strengthen the expression of odd numbered en stripes. (Fujioka et al., 1995) Crystallographic of the eve homeodomain complexed to an AT-rich oligonucleotide at 2.0 A resolution reveals a novel arrangement of two homeodomains bound to one 10bp DNA sequence in tandem fashion. (Hirsch and Aggarwal, 1995) The physical association of exd protein with Ubx protein and other HOM proteins is studied using a yeast two-hybrid system. (Johnson et al., 1995) The development of eve cells (cells from parasegments 4-12 that give rise to the pericardial cells of the heart) depends on at least wg and hh. Mosaic analysis demonstrates wg produced in the mesoderm alone is sufficient to generate eve cells. Also action of wg+ in the wild type ectoderm can restore the eve cells in the underlying wg- mesoderm. These two classes of mosaic clones demonstrate that wg protein in either germ layer is sufficient for the development of eve cells in the mesoderm and the patterning the mesoderm. Uniform expression of wg in the mesoderm only is sufficient to rescue the repeated clusters of eve expressing cells. (Lawrence et al., 1995) Dpic\eve has been cloned and sequenced and compared with D.melanogaster eve. (Sackerson, 1995) eve stripe 2 and 3 enhancers have been used to misexpress segmentation and homeotic genes. (Small and Kosman, 1995) eve efficiently blocks, or "squelches", Tbp-enhanced transcription in cotransfected Schneider L2 cells. Squelching does not require eve DNA-binding sites on the reporter plasmids used, but is dependent on the presence of the eve repression domain. (Um et al., 1995) Cell cycle progression and progression through S phase is required for eve expression in the CNS, cytokinesis is not required. Pc group genes are required for the repression of eve expression in the CNS. (Weigmann and Lehner, 1995) Within the hierarchy of genes expressed in GMC4-2a nub and pdm2 lie downstream of pros and ftz and upstream of eve. (Yeo et al., 1995) sna can repress a heterologous enhancer. (Gray et al., 1994) A potent repressor domain within the eve protein has been identified; localised between amino acids 212 and 245 and rich in Pro and hydrophobic amino acids. (Licht et al., 1994) Comparisons of early development to that in other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events. (Patel, 1994) In vivo crosslinking has been used to directly measure DNA binding of the homeodomain protein eve. eve protein binds at uniformly high levels throughout the length of their genetically identified target genes and at a lower, but significant level to genes eve is not expected to regulate. Studies suggest that ftz and eve has similar DNA binding specificities in vivo. (Walter et al., 1994) The eve product represses wg expression and transforms cells that would normally secrete naked cuticle into denticle secreting cells. (Brand and Perrimon, 1993) Ectopic ttk causes complete or near complete repression of ftz and significant repression of eve, odd, h and runt. (Brown and Wu, 1993) Expression of eve has been used as a marker for a subset of neuroblasts in study of requirement for wg gene product for neuroblast specification and formation in the CNS. (Chu-LaGraff and Doe, 1993) Complementation group identified in an EMS and DEB screen to isolate deficiencies that uncover Jra. (Goldstein et al., 1993) Expression of prd depends on activation by gap gene hb, Kr, kni and gt products. Primary pair rule gene products act primarily in subsequent modulation rather than activation of prd stripes. Factors activating prd expression in the pair rule mode interact with those activating it along the dorso-ventral axis. (Gutjahr et al., 1993) The eve gene product is a direct repressor that can repress activated transcription but does not function by binding to the TATA box of promoters. Deletion analysis reveals that both the proline and alanine rich regions of the eve gene product are required for maximal repression. (Han and Manley, 1993) wg expression is aberrantly activated and regulated in pair rule mutant embryos. (Ingham and Hidalgo, 1993) The role of eve in the regulation of run mRNA expression in the early embryo has been investigated. (Klingler and Gergen, 1993) Activation of en at the anterior margins of the parasegments requires repression of run and odd by eve. (Manoukian and Krause, 1993) Elements redundantly involved in enhancer activity in the autoregulatory domain of ftz are conserved in the AE homologs of D.virilis and D.hydei and in the developmentally regulated genes eve and Ubx. (Schier and Gehring, 1993) The eve stripe 3 enhancer lies 1.7kb upstream of the stripe 2 enhancer. The two enhancers must be separated by a minimum distance for proper stripe expression, though the order of enhancers can be reversed without affecting the normal expression pattern. (Small et al., 1993) eve can repress transcription at a distance. Tissue culture cell, in vitro transcription and DNaseI footprinting assays suggest that repression involves cooperative binding between eve molecules bound at distant sites in a manner similar to that used by some prokaryotic repressors. (TenHarmsel et al., 1993) Expression analysed in CNS study of neuroblasts and ganglion mother cells. (Doe, 1992) In vitro studies showed that Ubx and eve protein exert active and opposite effects on in vitro transcription when bound to a common site upstream of a target (Adh) core promoter: Ubx acts as an activator and eve acts as a repressor, and both affect the extent of preinitiation complex formation. A subsequent step renders mature complexes transiently refractory to activation and repression. (Johnson and Krasnow, 1992) Heat shock inducible eve transgene has been used to test the effects of eve expression on transcription of ftz, odd, run, prd, wg (proposed to be direct targets of eve), and eve, h and en (proposed to be indirect targets of eve). Delayed effects on eve and en appear to be mediated by odd and run. Ectopically expressed eve acts in a concentration-dependent manner on its different target genes. (Manoukian and Krause, 1992) eve protein expression during embryogenesis has been studied in D.melanogaster and grasshopper. (Patel et al., 1992) The 69kD ttk protein isoform binds multiple sites in the promoter and genetically defined autoregulatory element of eve. (Read and Manley, 1992) Maternally supplied ttk protein helps to establish the timing of the onset of zygotic expression of eve and ftz thereby preventing premature activation. (Read et al., 1992) Comparison of CpG distribution in the coding region of 121 genes from six species supports the mCpG mutational hotspot explanation of CpG suppression in methylated species at position II-III and III-I. (Schorderet and Gartler, 1992) Mutant analysis shows that wild type eve function is required to set up expression of ac in row D of the embryonic proneural cluster. (Skeath et al., 1992) Promoter fusions and expression pattern analysis show that a 480bp region is necessary and sufficient to direct eve stripe 2 expression. The gene products of bcd, hb, Kr and gt all bind within this 480bp region. (Small et al., 1992) Apical localization of pair-rule transcripts restricts lateral protein diffusion allowing pair-rule proteins to define sharp boundaries and precise spatial domains. (Davis and Ish-Horowicz, 1991) The cis and trans activating factors responsible for autoregulation are characterised using a combination of DNA binding and P-element transformation assays. Ecol\lacZ reporter gene studies demonstrate that eve autoregulation is mediated, at least in part, by a 100bp minimal autoregulatory sequence (MAS) located about 5kb upstream from the eve transcription start site. Results provide evidence that the eve protein acts combinatorially with other transcription factors to enhance its own expression. (Jiang et al., 1991) Mutations in zygotic pair rule gene eve interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) DNA binding assays and transient co-transfection assays in cultured cells suggest that repression of eve stripe 2 expression involves competition or short-range quenching mechanism. The binding of gt and Kr interferes with the binding of bcd and hb activators at overlapping or neighbouring sites within the eve stripe 2 promoter element. (Small et al., 1991) Ecol\lacZ reporter gene constructs carrying an eve promoter fragment were used to analyse the bcd, hb, Kr and gt binding sites present in the eve promoter. bcd, hb, Kr and gt are responsible for the expression of stripe 2. Mutations in the bcd or hb protein binding sites cause reduced expression of stripe 2 but do not alter the spatial limits. Mutations in Kr or gt protein binding sites do change the spatial limits of stripe 2. (Stanojevic et al., 1991) eve does not affect transcription from the mus209 promoter of mus209-Ecol\CAT reporter constructs. (Yamaguchi et al., 1991) The effects of an altered nucleocytoplasmic ratio on transcripts that normally undergo changes in transcript pattern in cell cycle 14 is studied. The development of the seven-striped transcript pattern of the segmentation gene eve is independent of the nuclear density and cell cycle program. (Yasuda et al., 1991) prd RNA expression has been studied in eve- embryos. (Baumgartner and Noll, 1990) The product of the eve gene probably interacts with a subset of the 'pair-rule' repressor elements located in the ftz promoter. (Dearolf et al., 1990) eve amorphic mutants eliminate all segmental periodicity. (Gaul and Jaeckle, 1990) Ubx, Kr and eve expression are altered in fs(1)h mutant embryos. (Huang and Dawid, 1990) Transcription of eve has been studied in vitro. (Read et al., 1990) In vitro DNA footprinting analysis shows that eve and zen can bind to sites in the mus209 5' flanking region. (Yamaguchi et al., 1990) eve can repress transcription from the Ubx promoter. (Biggin and Tjian, 1989) Injection of protein synthesis inhibitors into early embryos induces expression of eve mRNA in virtually all regions of the embryo. (Edgar et al., 1989) Analysis of eve gene expression reveals that distinct regulatory programs are required to first establish and then refine the periodic pattern of eve expression. (Goto et al., 1989) A transient expression assay has been employed to investigate the potential of homeobox genes to function as transcriptional activators. (Han et al., 1989) Ecol\lacZ reporter gene constructs have been used to identify cis control elements within the eve promoter that might mediate interactions with trans-acting factors encoded by gap and pair-rule genes. (Harding et al., 1989) The development of the eve and ftz stripes in h-, run-, eve- and en- embryos demonstrates that individual cells are allocated to parasegments with respect to the anterior margins of the eve and ftz stripes. (Lawrence and Johnston, 1989) Mutations in eve do not affect the spatial expression pattern of gt. (Mohler et al., 1989) The on/off periodicity of the pair-rule gene eve involves the interaction of the hb and Kr proteins with defined eve promoter elements. (Stanojevic et al., 1989) Genetic analysis demonstrates that eve is required for efficient homeotic gene expression in the visceral mesoderm. (Tremml and Bienz, 1989) The DNA binding activities of the en, eve, prd and zen proteins have been compared. (Hoey and Levine, 1988) eve protein expression has been analysed in various mutants that disrupt segmentation. (Frasch and Levine, 1987) Homozygous lethal; embryos homozygous for a null allele or a deficiency fail to undergo segmentation and their ventral surfaces are covered by a lawn of short denticles pointed toward the midline; denticles in the anterior region show thoracic characteristics suggesting that segmental identities persist in the absence of segmentation. All derivatives of gnathal segments are missing, such as maxillary sense organs, cirri, mouth hooks, labial sense organs and the mandibular parts of the cephalopharyngeal skeleton; the labrum, antennal sense organs and a rudimentary skeleton are the only remains of the larval head. Posteriorally, anal plates and some sensory organs persist as do remnants of spiracles, filzkorper and tufts. Homozygotes and hemizygotes for hypomorphic alleles display pair-rule segmentation defects. Denticle bands and adjacent naked cuticle of the prothoracic, metathoracic and even-numbered abdominal segments removed; some naked cuticle of the adjacent segment removed as well (i.e., the odd numbered parasegments are removed). Combinations of alleles with Df(2R)eve raised at different temperatures can achieve an array of phenotypes between these extremes. Expression of eve is first detected at the eleventh nuclear division following fertilization; at this stage, eve protein is uniformly distributed among the nuclei, both at the periphery and deep within the egg; by the thirteenth nuclear division, the anterior one-third of the embryo is devoid of detectable protein; over the next 20 minutes, the antibody staining in the posterior two-thirds of the embryo becomes concentrated in seven transverse stripes four or five cells wide separated by stripes three to four cells wide with lower levels of staining. By the time of germ-band elongation, the seven stripes have become narrowed and sharply defined and seven new weakly expressing stripes, one to two cells wide, appear between the major stripes; during germ-band elongation all stripes gradually disappear. As eve stripes become more sharply defined so too do ftz stripes, no longer overlapping eve stripes, but forming a complementary pattern. At the same time, a group of expressing cells appears at the posterior end of the germ band; these cells form a ring around the anal plate during germ-band shortening. Also during germ-band shortening, a specific subset of sixteen neurons in each hemisegment of the CNS expresses eve product as does a row of cell clusters on either side of the dorsal midline; lateral to these clusters are curious rings of weakly staining cells; the dorsal cells do not appear to be neuronal (Frasch, Hoey, Rushlow, Doyle and Levine, 1987; Frasch and Levine, 1987). In homozygous eve1 embryos switched to restrictive temperature during neurogenesis, four specifically studied eve-expressing neurons in each hemisegment are found to persist; two of them develop normally, but two send axonal processes to abnormal destinations (Doe, Smouse and Goodman, 1988). Frasch and Levine observe that segmentation-gene-mutations generally have reciprocal effects on the expression of eve and ftz, leading them to postulate that their promoters respond reciprocally to the same positional cues. eve concluded to be an early pair-rule gene, since its expression is modified by gap-gene mutations, but not by most other pair-rule gene mutations nor by segment-polarity gene mutations. Three pair-rule genes do influence eve expression: in either eve or h genotypes, eve expression is reduced and in run embryos eve is overexpressed (Frasch and Levine, 1987). In eve embryos, en stripes do not appear (Macdonald, Ingham, and Struhl, 1986). Ubx protein is detected at high level in odd-numbered parasegments from 7 through 13 rather than in every parasegment from 6 through 12 (Martinez-Arias and White, 1988). ftz stripes are disrupted in regularity of position, size and timing (Carroll and Scott, 1986).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078946 RefSeq (Proteins) • NP_523670 DDBJ / EMBL / GenBank • AAA28522 AAB05358 AAB05359 AAB05360 AAB05361 AAB05362 AAF58865 AF042709 CAA28784 CAA28785 M14767 S81995 U32087 U32088 U32089 U32090 U32091 X05138 X78903 Entrez Gene - A searchable database of RefSeq genes. • 36039 UniProtKB/Swiss-Prot • P06602
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 15016 InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeobox, eukaryotic (IPR020479) Homeodomain-related (IPR012287) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1JGG
Linkouts
	BioGRID - A database of protein and genetic interactions • 61867 DroID - A comprehensive database of gene and protein interactions. • FBgn0000606 DRSC - Results from RNAi screens. • FBgn0000606 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000606 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2328-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000606 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36039 InParanoid A subset of ortholog calls from InParanoid. • AAEL007369-PA Aedes aegypti (mosquito) AGAP010279-PA Anopheles gambiae (mosquito) XP_001120749.1 Apis mellifera (honey bee) XP_001947366.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000027866 Bos taurus (bovine) CE42059 Caenorhabditis elegans (worm) ENSCAFP00000004404 Canis familiaris (dog) JA01226 Caenorhabditis japonica (nematode) CPIJ013533 Culex pipens (mosquito) RP43575 Caenorhabditis remanei (nematode) 104183 Daphnia pulex (daphnia) ENSECAP00000011978 Equus caballus (horse) ENSGACP00000006040 Gymnopilus aculeatus (mushroom) ENSGALP00000037900 Gallus gallus (chicken) ENSP00000222761 Homo sapiens (human) ISCW018031-PA Ixodes scapularis (deer tick) ENSMMUP00000017697 Macaca mulatta (rhesus monkey) ENSMUSP00000107621 Mus musculus (house mouse) ENSOANP00000002362 Ornithorynchus anatinus (platypus) ENSORLP00000006363 Oryzias latipes (japanese killifish) PHUM007829-PA Pediculus humanus (human body louse) ENSPPYP00000019836 Pongo pygmaeus (orangutan) ENSPTRP00000032506 Pan troglodytes (chimpanzee) ENSRNOP00000010605 Rattus norvegicus (norway rat) ENSTNIP00000004184 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044950 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/evenskp1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36039 modMine - Data generated by the modENCODE project. • FBgn0000606 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15848 LH15244 ISCW001025 FBgn0236181 FBgn0024766 FBgn0064268 FBgn0040404 FBgn0176053 FBgn0020474 FBgn0154372 FBgn0142756 FBgn0015087 FBgn0024802 FBgn0088337 CPIJ013533 BGIBMGA009710 ACYPI005576 ACYPI003551 GB10623 AGAP010279 AAEL007369 PB23087 PHUM236390 GLEAN_09469 REDfly - A database of transcriptional regulatory elements. • FBgn0000606
Synonyms & Secondary IDs ( 34 )
Reported As
Symbol Synonym	10.5 (Currie and Sullivan, 1994) 10.9 (Currie and Sullivan, 1994) 14.10 (Currie and Sullivan, 1994) 20.35 (Currie and Sullivan, 1994) CG2328 (Zhang et al., 2002, Berman, 2003.1.15, Sackerson, 2003.3.7, Kreiman, 2004, Perkins et al., 2009, Ni et al., 2010.12.1, Hazelett et al., 2009, Keleman et al., 2009.8.5) E(eve) (Przeworski et al., 2001, Andolfatto and Przeworski, 2000) eve (Kozlov et al., 2009, Pearson et al., 2005, Peel et al., 2005, Grosskortenhaus et al., 2006, Struffi and Arnosti, 2005, Hallikas, 2006, Tucker and Chiquet-Ehrismann, 2006, Layden et al., 2006, Biemar et al., 2006, Wheeler et al., 2006, Hoskins et al., 2005, Bartolome and Charlesworth, 2006, Morais da Silva and Vincent, 2007, Surkova et al., 2007, Lemons and McGinnis, 2006, Sandmann et al., 2007, Halfon and Arnosti, 2007, Morozova et al., 2003, Kreiman, 2004, Mizutani et al., 2005, Stathopoulos and Levine, 2005, Zeremski et al., 2003, Aerts et al., 2007, Myasnikova et al., 2009, McDonald et al., 2003, Venken et al., 2009, Park et al., 2008, Segal et al., 2008, Hanyu-Nakamura et al., 2008, Nibu et al., 2003, Bergmann et al., 2007, Thomas and van Meyel, 2007, Jennings et al., 2006, Ludlam et al., 2002, Surkova et al., 2008, Andrioli et al., 2008, Schroeder and Gaul, 2008, Kim et al., 2008, Ullah et al., 2007, Philippakis et al., 2006, Goldstein et al., 2005, Xing et al., 2007, Holloway et al., 2006, Hare et al., 2008, Fowlkes et al., 2008, Clyde et al., 2003, Sandmann et al., 2006, Blankenship et al., 2006, Choksi et al., 2006, da Silva and Vincent, 2007, Fujimoto et al., 2008, Carrasco-Rando and Ruiz-Gómez, 2008, Fujioka et al., 2008, Estrada et al., 2007, Bhat, 2007, Liu et al., 2008, Surkova et al., 2008, Bosveld et al., 2008, Lott et al., 2007, Tögel et al., 2008, Lucchetta et al., 2008, Pym et al., 2006, Yu and Small, 2008, Hewitt et al., 1999, Chandraratna et al., 2007, Berger et al., 2008, Sellin et al., 2009, Lim and Kraut, 2009, Liu et al., 2009, Oktaba et al., 2008, van Impel et al., 2009, Kadam et al., 2009, Leal et al., 2009, Larsen et al., 2008, Gaziova and Bhat, 2009, Peterson et al., 2009, Shevelyov et al., 2009, Ochoa-Espinosa et al., 2009, Liu et al., 2009, Leaman et al., 2005, Lee et al., 2009, Nanda et al., 2009, Crocker and Erives, 2008, Weber et al., 2009, Buechling et al., 2009, Fang et al., 2009, Pisarev et al., 2009, Grimm et al., 2009, Butler et al., 2009, Schaaf et al., 2009, Fernandez-Gonzalez et al., 2009, Klingseisen et al., 2009, MacArthur et al., 2009, Janssens et al., 2006, Grosskortenhaus et al., 2005, Garces and Thor, 2006, Zhu et al., 2008, Babaoglan et al., 2009, Bertet et al., 2009, Fujioka et al., 2009, Payankaulam and Arnosti, 2009, Surkova et al., 2008, Lüer and Technau, 2009, Venken et al., 2009, Lacin et al., 2009, Leung and Eisen, 2009, Lucchetta et al., 2009, Wilkie et al., 2001, Grad et al., 2004, Luengo Hendriks et al., 2006, Keranen et al., 2006, de Wit et al., 2008, Neely et al., 2010, Satija et al., 2008, Braid et al., 2010, Gurunathan et al., 2004, Wang et al., 2010, Bauer and Bailey, 2008, Curtis et al., 2007, Zhang et al., 2010, Lusk and Eisen, 2010, Spirov and Holloway, 2003, Prazak et al., 2010, Lee et al., 1999, Walrad et al., 2011, Liu and Ma, 2011, Zhang and Arnosti, 2011, Stone et al., 2008, Roy et al., 2007, Tulin and Stathopoulos, 2010, Hazelett et al., 2009, Li and Arnosti, 2011, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Goto et al., 2011, Zhang et al., 2011, Bataillé et al., 2010, Ribeiro et al., 2010, Simões et al., 2010, Gursky et al., 2001, Bhat et al., 2011, Helman et al., 2011, Vorwald-Denholtz and De Robertis, 2011, Tchuraev and Galimzyanov, 2009, Fowlkes et al., 2011) EVE (Hartmann et al., 2000, Papatsenko et al., 2006, Shelton et al., 2009, MacArthur et al., 2009, Kanai et al., 2005, Udolph et al., 2009, Ho et al., 2009) Eve (Rogulja-Ortmann et al., 2007, Lacin et al., 2007, Sellin et al., 2006, Betschinger et al., 2006, Liu et al., 2006, Veitia, 2006, Alexander et al., 2006, Menon et al., 2005, Han et al., 2006, Zaffran et al., 2006, Ogawa, 2006, Monier et al., 2007, Merianda et al., 2005, Beckett and Baylies, 2006, Cheesman et al., 2004, Albrecht et al., 2006, Song and Taylor, 2003, Rawson et al., 2003, Benchabane et al., 2011, Liu et al., 2006, Vichas and Zallen, 2008, Lacin et al., 2008, Loer et al., 2008, Jain and Gavis, 2008, Mellerick and Liu, 2004, Johnson et al., 2007, Kim et al., 2007, Massarwa et al., 2007, Toledano-Katchalski et al., 2007, Haecker et al., 2008, Tsuji et al., 2008, Beckett and Baylies, 2007, Wong et al., 2008, Speicher et al., 2008, Walthall et al., 2007, Schafer et al., 2007, Junion et al., 2007, Mann et al., 2009, Huh et al., 2009, Noyes et al., 2008, Stagg et al., 2011, Bhuin and Roy, 2009, Umulis et al., 2010, Wei et al., 2007, Das et al., 2008, Bulchand et al., 2010, Grigorian et al., 2011, Meyer et al., 2009, Kitajima et al., 2010, Morton de Lachapelle and Bergmann, 2010, Mace et al., 2010, Slack et al., 2006) eve2 (Ochoa-Espinosa, 2006) F (Bour et al., 1995) l(2)46Ce (O'Brien et al., 1994, ) l(2)46CFg   l(2)46CFh   l(2)46CFj   l(2)46CFp   l(2)46Cg   unnamed (Yamamura and Nomura, 2001, Park and Datta, 1998, Goldstein et al., 1993) V (O'Brien et al., 1994) VI (O'Brien et al., 1994)
Name Synonym	Complementation group F (Goldstein et al., 2001, Bour et al., 1995) evenskip (Morozova et al., 2003) even-skiped (Gutierrez and Müller, 2008) even-skipped (Schmidt-Ott et al., 2005, Skeath and Thor, 2003, Holloway et al., 2002, Dworak and Sink, 2002, Andrioli and Small, 2002, Klingler and Bucher, 2002, Liu and Kaufman, 2002, Stanojevic, 1994.5.2, Frasch, 1994.6.3, Schwartz and Pirrotta, 2007, Riley, 2006, Payankaulam and Arnosti, 2007, Silva and Vincent, 2007, Lott et al., 2007, Payankaulam et al., 2006, Bird et al., 2006, Tucker and Chiquet-Ehrismann, 2006, Biemar et al., 2006, Veitia, 2006, Morais da Silva and Vincent, 2007, Halfon and Arnosti, 2007, Zeremski et al., 2003, Albrecht et al., 2006, Myasnikova et al., 2009, Park et al., 2008, Brown et al., 2005, Sanchez-Soriano and Prokop, 2005, Muller and Kassis, 2006, Lott et al., 2008, Kim et al., 2008, Levine and Tjian, 2003, Ullah et al., 2007, Philippakis et al., 2006, Goldstein et al., 2005, Xing et al., 2007, Holloway et al., 2006, Hare et al., 2008, DeFalco et al., 2008, Fujimoto et al., 2008, Liu et al., 2008, Bosveld et al., 2008, Zhang et al., 2004, Tögel et al., 2008, Lucchetta et al., 2008, Yu and Small, 2008, Oktaba et al., 2008, van Impel et al., 2009, Peterson et al., 2009, Ochoa-Espinosa et al., 2009, Lee et al., 2009, Crocker and Erives, 2008, Weber et al., 2009, Buechling et al., 2009, Pisarev et al., 2009, Butler et al., 2009, Leal et al., 2009, MacArthur et al., 2009, Garces and Thor, 2006, Surkova et al., 2008, Lüer and Technau, 2009, Wilkie et al., 2001, Keranen et al., 2006, Braid et al., 2010, Hsouna and VanBerkum, 2008, Zamparo and Perkins, 2009, Wang et al., 2010, Lusk and Eisen, 2010, Liu and Ma, 2011, Zhang and Arnosti, 2011, Singh et al., 2011, Bataillé et al., 2010, Ribeiro et al., 2010, Gursky et al., 2001, Helman et al., 2011, Vorwald-Denholtz and De Robertis, 2011, Mace et al., 2010) Even-skipped (Baum, 2004, Newfeld and Johnson, 2007, Mahr and Aberle, 2006, Tögel et al., 2007, Kolsch et al., 2007, Song and Taylor, 2003, Hsouna et al., 2003, McDonald et al., 2003, Vichas and Zallen, 2008, Hampoelz et al., 2005, Megason and Fraser, 2007, Mellerick and Liu, 2004, Massarwa et al., 2007, Cinnamon et al., 2008, Tsuji et al., 2008, Bhat, 2007, Chandraratna et al., 2007, Schafer et al., 2007, Bhuin and Roy, 2009, Ly et al., 2008, Udolph et al., 2009, Das et al., 2008, Prazak et al., 2010, Grigorian et al., 2011, Zhang et al., 2011, Kitajima et al., 2010, Morton de Lachapelle and Bergmann, 2010) evenskipped (Leatherman and Jongens, 2003, Beilfuss et al., 2003, Li et al., 2008, Walthall et al., 2007, Shi et al., 2009, Roy et al., 2007) Even Skipped (Carmena and Baylies, 2001, Bushati et al., 2008) even skipped (Jones et al., 2006, Wheeler et al., 2006, Pilot et al., 2006, Hanyu-Nakamura et al., 2008, Osterwalder et al., 2004, Choksi et al., 2006, da Silva and Vincent, 2007, Fujioka et al., 2008, Li et al., 2008, Kadam et al., 2009, Fang et al., 2009, Janssens et al., 2006, Babaoglan et al., 2009, Fujioka et al., 2009, Zhang et al., 2010, Lee et al., 1999, Li and Arnosti, 2011) Even skipped (Monier et al., 2007, Rawson et al., 2003, Kim et al., 2007, Toledano-Katchalski et al., 2007, Haecker et al., 2008, Estrada et al., 2007, Gaziova and Bhat, 2009) Even-Skipped (Reig et al., 2007, Speicher et al., 2008, Prazak et al., 2010) EVEN-SKIPPED (Ho et al., 2009) Group V (O'Brien et al., 1994) Group VI (O'Brien et al., 1994) lethal(2)46Ce (O'Brien et al., 1994)
Secondary FlyBase IDs
	FBgn0014159 FBgn0014984 FBgn0015483 FBgn0017400 FBgn0019712 FBgn0019718 FBgn0019720 FBgn0019721 FBgn0019816 FBgn0023205
References ( 1222 )
Generate a list of	All references relating to this gene ( 1222 )
List References by type	Research paper  ( 771 ) Supplementary material  ( 11 ) Review  ( 234 ) Erratum  ( 2 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 170 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 7 ) Conference report  ( 2 ) Stock list  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Obituary  ( 1 ) Automatic genome annotation  ( 1 ) Interview  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 ) Letter  ( 1 ) Poem  ( 1 )
Recent research papers ( 36 )
	Bhat et al., 2011, Dev. Biol. 351(1): 186--198 Neuralized mediates asymmetric division of neural precursors by two distinct and sequential events: promoting asymmetric localization of Numb and enhancing activation of Notch-signaling. [FBrf0214081] Clark et al., 2011, Development 138(13): 2705--2715 Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila. [FBrf0213889] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Dobi et al., 2011, Fly 5(2): 68--75 Characterization of early steps in muscle morphogenesis in a Drosophila primary culture system. [FBrf0213797] Fowlkes et al., 2011, PLoS Genet. 7(10): e1002346 A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila. [FBrf0216666] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Grigorian et al., 2011, Dev. Biol. 353(1): 105--118 The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. [FBrf0213410] Helman et al., 2011, Curr. Biol. 21(13): 1102--1110 Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. [FBrf0214255] Li and Arnosti, 2011, Curr. Biol. 21(5): 406--412 Long- and short-range transcriptional repressors induce distinct chromatin States on repressed genes. [FBrf0213170] Liu and Ma, 2011, Nat. Cell Biol. 13(1): 22--29 Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos. [FBrf0212612] McHale et al., 2011, Dev. Biol. 360(1): 230--240 Gene length may contribute to graded transcriptional responses in the Drosophila embryo. [FBrf0216627] Sayal et al., 2011, Fly 5(1): 47--52 Optimization of reporter gene architecture for quantitative measurements of gene expression in the Drosophila embryo. [FBrf0213005] Singh et al., 2011, Dev. Biol. 352(1): 104--115 The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo. [FBrf0213172] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Struffi et al., 2011, Development 138(19): 4291--4299 Combinatorial activation and concentration-dependent repression of the Drosophila even skipped stripe 3+7 enhancer. [FBrf0215233] Tsurumi et al., 2011, PLoS Genet. 7(5): e1002086 STAT Is an Essential Activator of the Zygotic Genome in the Early Drosophila Embryo. [FBrf0214235] Vorwald-Denholtz and De Robertis, 2011, Gene Expr. Patterns 11(7): 456--463 Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm. [FBrf0214814] Walrad et al., 2011, Mol. Biol. Cell 22(8): 1364--1374 Hairless is a cofactor for Runt-dependent transcriptional regulation. [FBrf0213441] Zhang and Arnosti, 2011, Mol. Cell. Biol. 31(2): 375--384 Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development. [FBrf0212606] Zhang et al., 2011, Dev. Biol. 353(2): 259--265 Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation. [FBrf0213522] Bataillé et al., 2010, Dev. Cell 19(2): 317--328 Downstream of Identity Genes: Muscle-Type-Specific Regulation of the Fusion Process. [FBrf0211535] Braid et al., 2010, Dev. Biol. 343(1-2): 178--189 Nemo phosphorylates Even-skipped and promotes Eve-mediated repression of odd-skipped in even parasegments during Drosophila embryogenesis. [FBrf0211008] Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707 Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459] Kitajima et al., 2010, Dev. Biol. 347(1): 9--23 Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. [FBrf0211968] Lusk and Eisen, 2010, PLoS Genet. 6(1): e1000829 Evolutionary mirages: selection on binding site composition creates the illusion of conserved grammars in Drosophila enhancers. [FBrf0209873] Mace et al., 2010, Bioinformatics 26(6): 761--769 Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization images. [FBrf0210155] Morton de Lachapelle and Bergmann, 2010, Mol. Syst. Biol. 6: 351 Precision and scaling in morphogen gradient read-out. [FBrf0210151] Neely et al., 2010, Cell 141(1): 142--153 A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. [FBrf0210524] Prazak et al., 2010, Dev. Biol. 344(2): 1048--1059 Non-additive interactions involving two distinct elements mediate sloppy-paired regulation by pair-rule transcription factors. [FBrf0211418] Repnikova et al., 2010, J. Neurosci. 30(18): 6466--6476 Sialyltransferase regulates nervous system function in Drosophila. [FBrf0210736] Ribeiro et al., 2010, Dev. Dyn. 239(11): 2989--2999 Investigating giant (Gt) repression in the formation of partially overlapping pair-rule stripes. [FBrf0212178] Simões et al., 2010, Dev. Cell 19(3): 377--388 Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation. [FBrf0211783] Tulin and Stathopoulos, 2010, BMC Dev. Biol. 10: 83 Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs. [FBrf0211620] Umulis et al., 2010, Dev. Cell 18(2): 260--274 Organism-Scale Modeling of Early Drosophila Patterning via Bone Morphogenetic Proteins. [FBrf0210054] Wang et al., 2010, PLoS ONE 5(7): e11498 NELF Potentiates Gene Transcription in the Drosophila Embryo. [FBrf0211281] Zhang et al., 2010, Mol. Cell. Biol. 30(5): 1158--1170 Sterile Alpha Motif Domain-Mediated Self-Association Plays an Essential Role in Modulating the Activity of the Drosophila ETS Family Transcriptional Repressor Yan. [FBrf0209952] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...