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Gene Dmel\e(y)1

General Information
Symbol	Dmel\e(y)1	Species	D. melanogaster
Name	enhancer of yellow 1	Annotation symbol	CG6474
Feature type	protein_coding_gene	FlyBase ID	FBgn0000617
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	dTAFII40, Taf9, TAFII40, dTAFII42, TFIID, dmTAF9, TAFII40, Taf40, TAF42, TAF40/42
Genomic Location
Chromosome (arm)	X	Recombination map	1-57.9
Cytogenetic map	16E1-16E1	Sequence location	X:17,736,194..17,737,381 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene enhancer of yellow 1 is referred to in FlyBase by the symbol Dmel\e(y)1 (CG6474, FBgn0000617). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly. There is experimental evidence that it is involved in the biological process: transcription from RNA polymerase II promoter. 11 alleles are reported. The phenotypes of these alleles are annotated with: ovary; oocyte; macrochaeta. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone-fold; Transcription factor TAFII-31. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1633139_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of e(y)1. Gene sequence location is X:17736208..17737381.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16E1-16E1   Limits computationally determined from genome sequence between P{EP}EP1464 and P{EP}EP970
Experimentally Determined Cytological Location
Cytogenetic map Notes References 16D4-16D5     (Goodrich, 1994.3.21) 16D-16D   (determined by in situ hybridisation)   (Zoldatov et al., 1997) 16D4-16D5   (determined by in situ hybridisation)   (Goodrich et al., 1993) 16B-16B   (determined by in situ hybridisation)   (Georgiev and Gerasimova, 1989)
Experimentally Determined Recombination Data
Location	1-57.9 (Zoldatov et al., 1997) 1-58.1 (Georgiev and Gerasimova, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\e(y)1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) e(y)1-RA FBtr0074463  NM_078667   1124   278
Additional Transcript Data & Comments
Reported size (kB)	1.3 (northern blot) (Goodrich et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein e(y)1-PA   FBpp0074237   29.3   278   9.93     NP_523391   AAF48767
Additional Polypeptide Data & Comments
Reported size (kDa)	278 (aa); 42 (kD observed); 29 (kD predicted) (Kokubo et al., 1994) 278 (aa); 29.3 (kD) (Goodrich et al., 1993) 40 (kD) (Dynlacht et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor TAFII-31 (IPR003162) Histone-fold (IPR009072) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1TAF
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA942356   AE014298 AAF48767   AW942846   AY061338 AAL28886   AZ877674   BF497861   BG637168   BI354250   BI580801   BI582143   BI582264   BI618566   BI625709   BP548651   BQ103184   BT031154   CO179870   CO180036   CO278873   CO285268   CO301594   CO304639   EC072474   EC079835   EC205768   EC245735   EC245887   ES692253   ES692260   ES692267   ES692268   EV592100   L29540 AAA28488   U06458 AAC47347   Z32473
UniProtKB/Swiss-Prot	Q27272
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	e(y)1 protein was isolated from nuclear extracts. (Goodrich et al., 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Wright et al., 2006, Weake et al., 2011, Hansen and Tjian, 1995, Goodrich et al., 1993, Guelman et al., 2006) SAGA complex inferred from direct assay (Weake et al., 2011, Guelman et al., 2006) inferred from physical interaction with Ada2b AND inferred from physical interaction with Spt3 AND inferred from physical interaction with dik (Kusch et al., 2003) transcription factor TFIID complex inferred from direct assay (Georgieva et al., 2001, Hansen and Tjian, 1995) inferred from physical interaction with Taf4 (Wright et al., 2006) inferred from physical interaction with Taf6 (Wright et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, adult crop, larval Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    242.7 Larval Midgut    64.6 Larval Hindgut    87.7 Larval Malpighian Tubules    106.9 Larval Fat Body    146 Larval Salivary Gland    170.4 Larval Trachea    148.525 Larval Carcass    67.65 Adult Head    88.2 Adult Eye    117.25 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    75 Adult Crop    110.1 Adult Midgut    98 Adult Hindgut    87.8 Adult Malpighian Tubules    75.2 Adult Fat Body    62.9 Adult Salivary Gland    140.8 Adult Heart    67.9 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    72.3 Adult Ovary    247.4 Adult Testis    39.3 Adult Male Accessory Gland    184.8 Adult Carcass    76.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    88.2   NA  Eye    117.25   NA  Brain    84   242.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    75   NA  Crop    110.1   no informative data  Midgut    98   87.7  Hindgut    87.8   106.9  Malpighian Tubules    75.2   146  Fat Body    62.9   170.4  Salivary Gland    140.8   NA  Heart    67.9   148.525  Trachea    NA   NA  VirginFemale Spermatheca    60.8   NA  InseminatedFemale Spermatheca    72.3   NA  Ovary    247.4   NA  Testis    39.3   NA  Male Accessory Gland    184.8   67.65  Carcass    76.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3  26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female  (27) testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3  26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female  27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    26 central nervous system, pupae P8    9 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    7 fat body, white prepupae    13 fat body, pupae P8    3 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    27 testis, mated 4-day male    10 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    90 embryo 04-06hr    83 embryo 06-08hr    82 embryo 08-10hr    70 embryo 10-12hr    58 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    30 adult female 05day    34 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (90) embryo 04-06hr  (83) embryo 06-08hr  (82) embryo 08-10hr  (70) embryo 10-12hr  (58) embryo 12-14hr  (33) embryo 14-16hr  (39) embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day  (30) adult female 05day  (34) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    90 embryo 04-06hr    83 embryo 06-08hr    82 embryo 08-10hr    70 embryo 10-12hr    58 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    30 adult female 05day    34 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    90 embryo 04-06hr    83 embryo 06-08hr    82 embryo 08-10hr    70 embryo 10-12hr    58 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    30 adult female 05day    34 adult female 30day    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    90 embryo 04-06hr    83 embryo 06-08hr    82 embryo 08-10hr    70 embryo 10-12hr    58 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    30 adult female 05day    34 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (90) embryo 04-06hr  (83) embryo 06-08hr  (82) embryo 08-10hr  (70) embryo 10-12hr  (58) embryo 12-14hr  (33) embryo 14-16hr  (39) embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day  30 adult female 05day  (34) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    90 embryo 04-06hr    83 embryo 06-08hr    82 embryo 08-10hr    70 embryo 10-12hr    58 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    30 adult female 05day    34 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    90 embryo 04-06hr    83 embryo 06-08hr    82 embryo 08-10hr    70 embryo 10-12hr    58 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    25 embryo 18-20hr    15 embryo 20-22hr    15 embryo 22-24hr    13 larva L1    18 larva L2    16 larva L3 12hr old    13 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    12 adult male 30day    13 adult female 01day    30 adult female 05day    34 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    19 embryonic Kc167    19 embryonic S1    34 embryonic S3    26 leg disc CME L1    37 wing disc CME-W2    15 wing disc ML-DmD8    26 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    68 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    23 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (44) Schneider line 2 Sg4  (39) embryonic 1182-4H  (37) embryonic GM2    19 embryonic Kc167    19 embryonic S1  (34) embryonic S3  26 leg disc CME L1  (37) wing disc CME-W2    15 wing disc ML-DmD8  26 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (41) wing disc ML-DmD21  (68) wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11  (35) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (31) CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    23 ovary fGS/OSS  (29) ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    19 embryonic Kc167    19 embryonic S1    34 embryonic S3    26 leg disc CME L1    37 wing disc CME-W2    15 wing disc ML-DmD8    26 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    68 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    23 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    19 embryonic Kc167    19 embryonic S1    34 embryonic S3    26 leg disc CME L1    37 wing disc CME-W2    15 wing disc ML-DmD8    26 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    68 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    23 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    19 embryonic Kc167    19 embryonic S1    34 embryonic S3    26 leg disc CME L1    37 wing disc CME-W2    15 wing disc ML-DmD8    26 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    68 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    23 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (44) Schneider line 2 Sg4  (39) embryonic 1182-4H  (37) embryonic GM2    19 embryonic Kc167    19 embryonic S1  (34) embryonic S3  26 leg disc CME L1  (37) wing disc CME-W2    15 wing disc ML-DmD8  26 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (41) wing disc ML-DmD21  (68) wing disc ML-DmD32  (33) haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11  (35) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  31 CNS ML-DmBG1-c1  (33) CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    23 ovary fGS/OSS  29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    19 embryonic Kc167    19 embryonic S1    34 embryonic S3    26 leg disc CME L1    37 wing disc CME-W2    15 wing disc ML-DmD8    26 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    68 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    23 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    39 embryonic 1182-4H    37 embryonic GM2    19 embryonic Kc167    19 embryonic S1    34 embryonic S3    26 leg disc CME L1    37 wing disc CME-W2    15 wing disc ML-DmD8    26 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    41 wing disc ML-DmD21    68 wing disc ML-DmD32    33 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    33 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    23 ovary fGS/OSS    29 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    22 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    22 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD26511 RE24789 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000617 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6474-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable e(y)11 Sterility Allele female fertile e(y)1P1 female sterile | recessive e(y)11 e(y)12 Other Phenotypes Allele visible | male | recessive e(y)1P1 wild-type e(y)1+tSa Phenotype manifest in Allele macrochaeta e(y)1P1 oocyte e(y)11 ovary e(y)11
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of e(y)1 Class Mutagen Stocks Known lesion e(y)11 Stalker-hybrid dysgenesis 0 Yes e(y)12 Stalker-hybrid dysgenesis 0 Yes e(y)1BG00948 P-element activity 0 -- e(y)1P1 PM hybrid dysgenesis 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of e(y)1 Class Mutagen Stocks Known lesion e(y)1HMS00336 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes e(y)1+tSa in vitro construct - genomic fragment 0 Yes e(y)11.tSa in vitro construct 0 Yes e(y)1Act5C.PF in vitro construct - regulatory fusion 0 Yes e(y)1dsRNA.cWa in vitro construct - RNAi 0 Yes e(y)1GD4407 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes e(y)1NIG.6474R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4407} NA P{NIG.6474R} NA P{TRiP.HMS00336} NA characterization construct P{e(y)11.tSa} NA P{e(y)1+tSa} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}e(y)1P1 NA P{GT1}e(y)1BG00948 NA Stalker{}e(y)11 NA Stalker{}e(y)12 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
contributes_to RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly inferred from direct assay (Hansen and Tjian, 1995) transcription factor binding inferred from physical interaction with e(y)2 (Georgieva et al., 2001)
Biological Process
CV term Evidence References
transcription from RNA polymerase II promoter inferred from direct assay (Hansen and Tjian, 1995)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Wright et al., 2006, Weake et al., 2011, Hansen and Tjian, 1995, Goodrich et al., 1993, Guelman et al., 2006) SAGA complex inferred from direct assay (Weake et al., 2011, Guelman et al., 2006) inferred from physical interaction with Ada2b AND inferred from physical interaction with Spt3 AND inferred from physical interaction with dik (Kusch et al., 2003) transcription factor TFIID complex inferred from direct assay (Georgieva et al., 2001, Hansen and Tjian, 1995) inferred from physical interaction with Taf4 (Wright et al., 2006) inferred from physical interaction with Taf6 (Wright et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from electronic annotation with InterPro:IPR009072 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with human TAF9B AND inferred from sequence or structural similarity with Saccharomyces TAF17 (Aoyagi and Wassarman, 2000)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:Q62880 (FlyBase, 1992-) transcription factor TFIID complex inferred from sequence or structural similarity with human TAF9B AND inferred from sequence or structural similarity with Saccharomyces TAF17 (Aoyagi and Wassarman, 2000) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
e(y)1 - CG13026 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) e(y)1 - CG4962 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) e(y)1 - His2B:CG33868 experimental knowledge based (Guruharsha et al., 2011) e(y)1 - His4r experimental knowledge based (Guruharsha et al., 2011) e(y)1 - Nplp2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) e(y)1 - Rfabg experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) e(y)1 - Taf10 anti bait coimmunoprecipitation, western blot (Georgieva et al., 2001) e(y)1 - Tbp anti bait coimmunoprecipitation, western blot (Georgieva et al., 2001) e(y)1 - e(y)2 anti bait coimmunoprecipitation, western blot (Georgieva et al., 2001)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions e(y)1 allele Gene References e(y)11 e(y)3 (Soldatov et al., 1999) sc (Gause et al., 1996) w (Soldatov et al., 1999) y (Georgiev and Gerasimova, 1989, Soldatov et al., 1999) z (Georgiev, 1994) e(y)12 y (Georgiev and Gerasimova, 1989) e(y)1P1 ph-p (Soldatov et al., 1999) y (Georgiev and Gerasimova, 1989) unspecified ct (Melnikova et al., 1996) w (Georgiev, 1994)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59084 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000617 DroID - A comprehensive database of gene and protein interactions. • FBgn0000617 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32762
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TQMWD Dipteran inclusive ortholog search EOG65MNFF Insect inclusive ortholog search EOG6H18S5 Arthropod inclusive ortholog search EOG60VT5X Metazoa inclusive ortholog search EOG6PP9B4
Orthologs in Drosophila Species (EOG6TQMWD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\e(y)1     Drosophila simulans   Dsim\GD17368 Y   Drosophila sechellia   Dsec\GM22857 Y   Drosophila erecta   Dere\GG19133 Y   Drosophila yakuba   Dyak\GE17689 Y   Drosophila ananassae   Dana\GF21106 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26884 Y   Drosophila persimilis   Dper\GL14751 Y   Drosophila willistoni   Dwil\GK25325 Y   Drosophila virilis   Dvir\GJ23848 Y   Drosophila mojavensis   Dmoj\GI22602 Y   Drosophila grimshawi   Dgri\GH19399 Y
Orthologs in non-Drosophila Dipterans (EOG65MNFF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006789   Anopheles gambiae Malaria mosquito  Agam\AGAP003094   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001398
Orthologs in non-Dipteran Insects (EOG6H18S5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52516   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002195   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002199   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22063   Atta cephalotes Leafcutter ant  Acep\ACEP15170   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19298   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21259   Linepithema humile Argentine ant  Lhum\LH18010   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10782   Acyrthosiphon pisum Pea aphid  Apim\ACYPI071333   Acyrthosiphon pisum Pea aphid  Apim\ACYPI060797   Acyrthosiphon pisum Pea aphid  Apim\ACYPI066001   Acyrthosiphon pisum Pea aphid  Apim\ACYPI064182   Acyrthosiphon pisum Pea aphid  Apim\ACYPI085994   Acyrthosiphon pisum Pea aphid  Apim\ACYPI089480   Acyrthosiphon pisum Pea aphid  Apim\ACYPI43415   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002736   Acyrthosiphon pisum Pea aphid  Apim\ACYPI071209   Acyrthosiphon pisum Pea aphid  Apim\ACYPI30466   Acyrthosiphon pisum Pea aphid  Apim\ACYPI073872   Bombyx mori Silkmoth  Bmor\BGIBMGA007359   Pediculus humanus Human body louse  Phum\PHUM076550   Tribolium castaneum Red flour beetle  Tcas\TC004292
Orthologs in non-Insect Arthropods (EOG60VT5X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Ixodes scapularis Deer tick  Isca\ISCW005230   Ixodes scapularis Deer tick  Isca\ISCW012450
Orthologs in non-Arthropod Metazoa (EOG6PP9B4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\taf-9   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021928gn   Danio rerio Zebrafish  Drer\taf9   Xenopus tropicalis Western clawed frog  Xtro\taf9b   Gallus gallus Domestic chicken  Ggal\TAF9   Mus musculus House mouse  Mmus\Taf9   Mus musculus House mouse  Mmus\Taf9b   Rattus norvegicus Norway rat  Rnor\Taf9b   Homo sapiens Human  Hsap\TAF9B
Human Orthologs (1)
Gene OMIM HGNC Hsap\TAF9B
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17368 Drosophila sechellia Dsec\GM22857 Drosophila erecta Dere\GG19133 Drosophila yakuba Dyak\GE17689 Drosophila ananassae Dana\GF21106 Drosophila pseudoobscura pseudoobscura Dpse\GA26884 Drosophila persimilis Dper\GL14751 Drosophila willistoni Dwil\GK25325 Drosophila virilis Dvir\GJ23848 Drosophila mojavensis Dmoj\GI22602 Drosophila grimshawi Dgri\GH19399
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	32345 y1 sc* v1; P{TRiP.HMS00336}attP2
Genomic Clones ( 1 )
	BACR01N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD26511 RE24789
Other clones	DPiM_LD26511
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12164 GM16103 RE75037 RH20078 RH20229 RH49429 RH66184 SD15039
Other clones	15327 52863 55036 CK01.16C.C10 CK01.117B.G12 Dmel_neb_013165_0642_0673 EC00413 EC00813 EK131945 EK168640 EK181619 EK245403 FGM001A06 RC0-DA0007-130700-013-B12 RC0-DA0007-130700-013-D11 RC0-DA0007-130700-013-G10 RC0-DA0007-130700-013-G12 UUGC0582
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000617 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32762
Antibody Information
	monoclonal, polyclonal (Goodrich et al., 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: e(y)1 e(y)4 (Soldatov et al., 1999)
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Marr et al., 2006) The proteins encoded by Taf4, Taf5, Taf6, e(y)1 and Taf12 form a core sub-complex of TFIID. (Wright et al., 2006) Expression of the y and w genes is sensitive to the level of e(y)1 expression. (Soldatov et al., 1999) Does not interact, in vitro, with human thryroid-hormone receptor-β. (Petty et al., 1996) The amino terminal portions of e(y)1 and Taf6 adopt the canonical histone fold, consisting of two short α-helices flanking a long central α helix. e(y)1 and Taf6 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules. In solution and in the crystalline state the e(y)1/Taf6 complex exists as a heterotetramer, resembling the (His3/His4)2 heterotetrameric core of the histone octamer, suggesting that TFIID contains a histone octamer-like substructure. (Xie et al., 1996) The assembly and purification of various functional Tbp TAF complexes demonstrate that Tbp plus the TAFs is sufficient to replace endogenous TFIID to support activated transcription in vitro. (Chen et al., 1994) TFIID subunit proteins and the Tbp protein can interact in pairwise combinations with several subunits in a network of interactions within TFIID. (Kokubo et al., 1994) The TFIID complex interacts with the promoters of Hsp70Bb, Hsp70Bc, Hsp26 and His3 making contacts at the TATA element, initiator, +18 and +28 regions. (Purnell et al., 1994) A number of polypeptides (encoded by Taf1, Taf4, Taf5, Taf6, e(y)1 and Taf12) that are tightly associated with Tbp and are native TFIID components have been purified. Protein blotting experiments suggest that one of these proteins, Taf1, interacts directly with Tbp, while the association between Tbp and the other proteins is either weak or is an indirect association via Taf1. (Kokubo et al., 1993) The e(y)1 protein interacts directly with the Taf6 protein. Tbp, Taf1, Taf4 and Taf6 products can assemble into a mini-complex in vitro, showing that Taf6 and Taf4 occupy distinct binding sites on the C terminal part of Taf1. (Weinzierl et al., 1993) The effects of all e(y) alleles on bristle color persist in the presence of su(Hw)2. No effect on the phenotype of y+. (Lindsley and Zimm, 1992) e(y)1 modifies the expression of y2, a gypsy-induced allele, but not other gypsy-induced mutations. (Lindsley and Zimm, 1992) Mutations at the e(y)1 loci enhance the phenotypic expression of several insertion mutations of y without exerting any effect on gypsy induced mutations at other loci. Some mutations in e(y)1 are due to insertion of a Stalker element. (Georgiev et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078667 RefSeq (Proteins) • NP_523391 DDBJ / EMBL / GenBank • AA942356 AAA28488 AAC47347 AAF48767 AAL28886 AW942846 AY061338 AZ877674 L29540 U06458 Z32473 Entrez Gene - A searchable database of RefSeq genes. • 32762 UniProtKB/Swiss-Prot • Q27272
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor TAFII-31 (IPR003162) Histone-fold (IPR009072) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1TAF BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD26511 RE24789
Linkouts
	BioGRID - A database of protein and genetic interactions • 59084 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000617 DroID - A comprehensive database of gene and protein interactions. • FBgn0000617 DRSC - Results from RNAi screens. • FBgn0000617 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000617 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6474-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000617 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32762 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32762 modMine - Data generated by the modENCODE project. • FBgn0000617
Synonyms & Secondary IDs ( 40 )
Reported As
Symbol Synonym	CG6474 (Aoyagi and Wassarman, 2000, Weake et al., 2009, Ni et al., 2010.12.1, Riedl et al., 2005) d40 (Pugh, 2000) dme-TAFII40 (Baxevanis et al., 1995) dmTAF9 (Lebedeva, 2005, Lebedeva et al., 2005, Muratoglu et al., 2003, Lebedeva et al., 2004) dmTaf9 (Kusch et al., 2003) dTAF9 (Chen and Manley, 2003, Guelman et al., 2006) dTAF42 (Nogales, 2000, Hoffmann et al., 1996) dTAF40 (Burke and Kadonaga, 1997) dTAFII40 (Georgieva et al., 2001, Gangloff et al., 2001, Veenstra and Wolffe, 2001, Lively et al., 2001, Park et al., 2001, Pugh, 2000, Aasland, 1999, Georgieva et al., 2000, Albright and Tjian, 2000, Mantovani, 1999, Naar et al., 1998, Burke et al., 1998, Zhou et al., 1998, Kobayashi et al., 1998, Mahanta et al., 1997, Chen and Tjian, 1996, Damania and Alwine, 1996, Goodrich and Tjian, 1994, Yokomori et al., 1993, Goodrich et al., 1993, Wright et al., 2006) dTAFII42 (Pugh, 2000, Burley, 1998, Maity and de Crombrugghe, 1998, Felsenfeld, 1996, Xie et al., 1996, Surridge, 1996, Nakatani et al., 1996) dTAFII42 (Saurin et al., 2001) e(y)1 (Georgieva et al., 2001, Toku et al., 2011, Kind et al., 2008, Guelman et al., 2006, Japanese National Institute of Genetics, 2012.5.21) E(y)1 (Riedl et al., 2005) e(y)4   e(y)1 (Georgiev et al., 1990) p42 (Kokubo et al., 1994, Kokubo et al., 1993) Taf9 (Lebedeva, 2005, Lebedeva et al., 2005, Marr et al., 2006, Spedale et al., 2012) TAF9 (Tora, 2002, Maile et al., 2004, Wright et al., 2006, Metcalf and Wassarman, 2007, Vorobyeva et al., 2009, Weake et al., 2011, Wright and Tjian, 2009, Weake et al., 2009, Santoso and Kadonaga, 2006, Vorobyeva et al., 2009, Lebedeva et al., 2007, Soshnikova et al., 2008, Vorobyeva et al., 2008) Taf40 (Struhl and Moqtaderi, 1998, ) TAF40 (Hansen et al., 1997, Farmer et al., 1996) TAF40/42 (Green, 2000, Hahn, 1998) TAF40/42/e(y)1 (Aoyagi and Wassarman, 2000) taf40/e(y)1 (Simonova and Modestova, 2003) TAF42 (Sandaltzopoulos and Becker, 1998, Hoey et al., 1993) Taf42 (Madueno et al., 1995, ) TAFII (Arnosti, 2002) TAFII40 (Lebedeva, 2005, Lebedeva et al., 2005, Butler and Kadonaga, 2002, Tora, 2002, Sauer et al., 1996, Hansen and Tjian, 1995) TafII40 (Chen et al., 1994) TAFII40/42 (Shen et al., 1998, Tansey and Herr, 1997) TAFII42 (Tsukiyama and Wu, 1997, Wang and Brock, 2003) TAFII40 (Kennett et al., 2002) TAFII40 (Georgieva et al., 2001, Goodrich, 1994.3.21, Dynlacht et al., 1993, Dynlacht et al., 1991) TAFII40(42) (Berk, 1999) TFIID (Butler and Kadonaga, 2002, Simon and Tamkun, 2002, Hochheimer et al., 2002, Gu et al., 2002, Stathopoulos and Levine, 2002, Mizuguchi et al., 2001) TFIID 42 (Nakatani, 1994.2.8) TFIID-p42
Name Synonym	enhancer of yellow 1   enhancer of yellow 4   TBP-associated factor (Schuettengruber et al., 2007) TBP-associated factor 40kD
Secondary FlyBase IDs
	FBgn0000620 FBgn0011302
References ( 133 )
Generate a list of	All references relating to this gene ( 133 )
List References by type	Research paper  ( 76 ) Supplementary material  ( 5 ) Review  ( 29 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Letter  ( 2 ) Stock list  ( 1 ) Book  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews ( 1 )
	Spedale et al., 2012, Genes Dev. 26(6): 527--541 ATAC-king the complexity of SAGA during evolution. [FBrf0219841] Show all reviews ...