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Gene Dmel\eyg

General Information
Symbol	Dmel\eyg	Species	D. melanogaster
Name	eyegone	Annotation symbol	CG10488
Feature type	protein_coding_gene	FlyBase ID	FBgn0000625
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-37--38
Cytogenetic map	69C2-69C2	Sequence location	3L:12,455,637..12,461,121 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eyegone is referred to in FlyBase by the symbol Dmel\eyg (CG10488, FBgn0000625). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II regulatory region sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: notum development; eye development; antennal development; eye-antennal disc development; compound eye development; negative regulation of transcription from RNA polymerase II promoter; compound eye morphogenesis. 56 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; imaginal precursor; adult; thoracic segment; external compound sense organ; multicellular structure; eo support cell; salivary gland imaginal ring. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain-like; Paired domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1632742_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of eyg. Gene sequence location is 3L:12455637..12461121.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	eyg: eye gone Eyes and head much smaller than normal. Considerable pupal mortality, probably from inability to push open pupa cases. Adults normal in viability and productivity. Character subject to genetic modifiers and possibly environmental influences. Expression varies from complete absence of facets to formation of about 100 facets. Homozygotes show reduced larval and pupal survival (Inoue, 1980, DIS 55: 206). Lethal in combination with ey; phenotype described under ey [Hunt, 1970, Genet. Res. 15: 29-34 (fig.)]. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69C2-69C2   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-35.5 (Wurst et al., 1984) 3-37--38 (Robertson and Malpica, 1972)
Left of (cM)
Right of (cM)	Est-6 (Robertson and Malpica, 1972)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eyg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eyg-RA FBtr0075979  NM_079318   2691   670 eyg-RB FBtr0100170  NM_001014582   2624   670 eyg-RC FBtr0339921     3148   670
Additional Transcript Data & Comments
Reported size (kB)	2.655 (longest cDNA) (Jun et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eyg-PA   FBpp0075711   70.1   670   8.11     NP_524042   AAF49918 eyg-PB   FBpp0099525   70.1   670   8.11     NP_001014582   AAX52747 eyg-PC   FBpp0308953   70.1   670   8.11
Additional Polypeptide Data & Comments
Reported size (kDa)	523 (aa) (Jun et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Paired domain (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49918   AE014296 AAX52747   AF091739 AAC78330   AY099362 AAM43805   AY167573 AAN87345   AY167574   BT021470 AAX33618   CZ469827   DQ017410 AAY82192   DQ017411 AAY82193   GH956683   GH977556
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VTX7 Q8MTJ1 O77238 Q7YSG8 Q3YNE2 Q5BHV4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epidermis | segmentally repeated   (Jun et al., 1998) embryonic head | restricted   (Jun et al., 1998) embryonic/larval posterior spiracle | vicinity of   (Jun et al., 1998) embryonic stage 11 -- 17   salivary gland body primordium   (Jun et al., 1998) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   adult eye primordium   (Jang et al., 2003) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland body specific anlage embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) Bolwig organ primordium   (Fisher et al., 2012) Comment:reported as larval eye primordium dorsal epidermis primordium   (Fisher et al., 2012) embryonic optic lobe primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic antennal sense organ   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) second instar larval stage -- third instar larval stage   eye disc   (Jang et al., 2003) Comment:late second/early third instar eye disc | anterior   (Jang et al., 2003) Comment:late second/early third instar third instar larval stage   ventral thoracic disc | restricted   (Jang et al., 2003) eye disc | dorsal & morphogenetic furrow | anterior to   (Jang et al., 2003) antennal disc | central   (Jang et al., 2003) wing disc | restricted   (Jang et al., 2003)
Additional Descriptive Data
	Eye disc primordia express eyg in embryos. Expression of eyg in eye discs is detected at least as early as late second instar. eyg transcript is detected in the anterior of early larval eye discs and is strongly expressed dorsally and anterior to the morphogenetic furrow in late eye discs. Expression also occurs in the central region of antennal discs, the anterior notum, dorsal hinge and a region of the posterior periphery in the wing disc and in several restricted areas of the leg disc. (Jang et al., 2003) eyg is expressed in the salivary gland placode from stage 11. Expression is uniform at first in the placode and later fades in some areas such that a crescent pattern is formed. Expression is also observed in the subantennal region of the head and in a segmentally repeated pattern in the trunk. The segmental pattern begins as a single cell in each segment and develops into a ventrally located patch that fades to a narrow stripe during germ band retraction. Expression is also observed in the region around the posterior spiracle. (Jun et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc | restricted   (Aldaz et al., 2003)
Additional Descriptive Data
	eyg protein can first be detected in third instar wing discs and is restricted to the anterior compartment in a region destined to become the anterior central region of the mesothorax. (Aldaz et al., 2003)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Yao and Sun, 2005)
Expression Deduced from Reporters
Reporter: P{GawB}EM461 Stage Tissue/Position (including subcellular localization) Reference larval stage   wing hinge | presumptive   (Aldaz et al., 2003) scutum | presumptive   (Aldaz et al., 2003) wing disc | anterior compartment & restricted   (Aldaz et al., 2003) adult stage   genitalia   (Aldaz et al., 2003) antenna   (Aldaz et al., 2003) scutum   (Aldaz et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland    512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland  512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland    512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland    512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland    512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland  512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland    512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.225 Larval Midgut    3.4 Larval Hindgut    2.7 Larval Malpighian Tubules    2 Larval Fat Body    2.2 Larval Salivary Gland    216.5 Larval Trachea    2.3 Larval Carcass    11.2 Adult Head    21.2 Adult Eye    60.225 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    1.5 Adult Crop    7 Adult Midgut    5.2 Adult Hindgut    4.7 Adult Malpighian Tubules    1.1 Adult Fat Body    10 Adult Salivary Gland    512.2 Adult Heart    1.425 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.4 Adult Ovary    1.5 Adult Testis    5.1 Adult Male Accessory Gland    93.9 Adult Carcass    12.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    60.225   NA  Brain    3.1   9.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.5   NA  Crop    7   3.4  Midgut    5.2   2.7  Hindgut    4.7   2  Malpighian Tubules    1.1   2.2  Fat Body    no informative data   216.5  Salivary Gland    512.2   NA  Heart    1.425   2.3  Trachea    NA   NA  VirginFemale Spermatheca    5.8   NA  InseminatedFemale Spermatheca    9.4   NA  Ovary    1.5   NA  Testis    5.1   NA  Male Accessory Gland    93.9   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    23 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    5 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • AT09010 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000625 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10488-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for eyg Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal eyg54A3 eygP20MD1 lethal | pharate adult stage | recessive eyg94-4 lethal | pupal stage | recessive eygM3-12 lethal | recessive eygPxA1 partially lethal - majority die eyg1 viable eyg37-1 eygc05307 eygXE119 eygXS496 viable, with Scer\GAL4pnr-MD237 eygGD1442 Sterility Allele fertile eygc05307 Other Phenotypes Allele cell growth defective | somatic clone eygP20MD1 hyperplasia, with Scer\GAL4dpp.blk1 eygScer\UAS.lune increased cell death eyg1 planar polarity defective, with Scer\GAL4455.2 eygScer\UAS.cAa planar polarity defective, with Scer\GAL4MD-638 eygScer\UAS.cAa planar polarity defective, with Scer\GAL4MS248 eygScer\UAS.cAa planar polarity defective, with Scer\GAL4pnr-MD237 eygScer\UAS.cAa planar polarity defective, with Scer\GAL4ush-MD751 eygScer\UAS.cAa visible eyg1 eygM3-12 visible, with Scer\GAL4CD eygScer\UAS.T:Hsim\VP16 visible, with Scer\GAL4MS248 eygScer\UAS.cAa visible, with Scer\GAL4pnr-MD237 eygGD1442 visible, with Scer\GAL80ts.αTub84B eygScer\UAS.T:Hsim\VP16 visible | semidominant eyg64e Phenotype manifest in Allele adult cuticle | ectopic, with Scer\GAL4ey.PH eygScer\UAS.lune adult head eygM3-12 adult head, with Scer\GAL4CD eygScer\UAS.T:Hsim\VP16 adult head | heat sensitive, with Scer\GAL4CD, Scer\GAL80ts.αTub84B eygScer\UAS.T:Hsim\VP16 adult head | ventral, with Scer\GAL4ey.PH eygScer\UAS.lune adult thorax eygM3-12 dorsocentral bristle (with Df(3L)iro-2) eygSA2 eyggv5 embryonic/larval salivary gland duct | embryonic stage eygC53 eye eyg1 eyg37-1 eyg94-4 eygXE119 eye, with Scer\GAL4CD eygScer\UAS.T:Hsim\VP16 eye, with Scer\GAL4dpp.blk1 eygScer\UAS.T:Hsim\VP16 eye, with Scer\GAL4ey.PH eygScer\UAS.lune eye, with Scer\GAL4eyg-22-2 eygΔPD.Scer\UAS eye (with eyg1) eygM3-12 eye (with eygM3-12) eyg1 eygXE119 eye (with eygXE119) eygM3-12 eye (with In(3L)gvU) eyg1 eye | ectopic, with Scer\GAL4ey.PH eygScer\UAS.lune eye | ectopic, with Scer\GAL4eyg-22-2 eygΔPAI.Scer\UAS eygen.Scer\UAS eye | ectopic, with Scer\GAL4upd-E132 eygScer\UAS.lune eye | ectopic | ventral, with Scer\GAL4dpp.blk1 eygΔC.Scer\UAS eyg325.Scer\UAS eyg554.Scer\UAS.T:SV40\nls2 eye | heat sensitive, with Scer\GAL4CD, Scer\GAL80ts.αTub84B eygScer\UAS.T:Hsim\VP16 eye | pharate adult stage, with Scer\GAL4eyg-22-2, eyg22-2/eygM3-12 eygΔL.ΔRED.Scer\UAS eygΔPAI.ΔL.Scer\UAS eygΔPD.Scer\UAS eygΔRED.Scer\UAS eygC.Scer\UAS eye | pharate adult stage (with eyg22-2) eygM3-12 eye | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygC.Scer\UAS eygM3-12 eye | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔL.ΔRED.Scer\UAS eygM3-12 eye | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔPAI.ΔL.Scer\UAS eygM3-12 eye | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔPD.Scer\UAS eygM3-12 eye | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔRED.Scer\UAS eygM3-12 eye | pharate adult stage (with eygM3-12) eyg22-2 eye | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygC.Scer\UAS eyg22-2 eye | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔL.ΔRED.Scer\UAS eyg22-2 eye | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔPAI.ΔL.Scer\UAS eyg22-2 eye | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔPD.Scer\UAS eyg22-2 eye | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔRED.Scer\UAS eyg22-2 eye | somatic clone eygP20MD1 eye | supernumerary | ventral, with Scer\GAL4dpp.blk1 eyg438.Scer\UAS eyg554.Scer\UAS eyg643.Scer\UAS eyg670.Scer\UAS eye | supernumerary | ventral, with Scer\GAL4dpp.blk1, eygmHD.Scer\UAS eygmPD.Scer\UAS eye | supernumerary | ventral, with Scer\GAL4dpp.blk1, eygmPD.Scer\UAS eygmHD.Scer\UAS eye-antennal disc eyg158M26 eygM3-12 eygP20MD1 eye-antennal disc, with Scer\GAL4dpp.blk1 eygScer\UAS.lune eye-antennal disc, with Scer\GAL4ey.PH eygScer\UAS.lune eye-antennal disc | proximal | somatic clone, with Scer\GAL4Act5C.PI eygScer\UAS.lune eye-antennal disc | somatic clone eygP20MD1 eye disc eyg1 eyg123M11 eyg158M26 eyg54A3 eyg76M26 eygM26 eygP20MD1 eye disc (with Df(3L)eygC1) eyg1 eye disc (with Df(3L)iro-2) eygP20MD1 eye disc | cell non-autonomous | somatic clone eygP20MD1 head eyg1 eyg94-4 eygM3-12 eygP20MD1 eygPxA1 head, with Scer\GAL4eyg-22-2 eygScer\UAS.T:Hsim\VP16 head, with Scer\GAL4eyg-22-2, eyg22-2/eygM3-12 eygScer\UAS.T:Hsim\VP16 eygmPD.mHD.Scer\UAS head (with eyg22-2), with Scer\GAL4eyg-22-2, eygmPD.mHD.Scer\UAS eygM3-12 head (with eyg22-2), with Scer\GAL4eyg-22-2, eygScer\UAS.T:Hsim\VP16 eygM3-12 head (with eygM3-12), with Scer\GAL4eyg-22-2, eygmPD.mHD.Scer\UAS eyg22-2 head (with eygM3-12), with Scer\GAL4eyg-22-2, eygScer\UAS.T:Hsim\VP16 eyg22-2 head (with In(3L)gvU) eygEq-2-d2-2 head | pharate adult stage eygM3-12 head | pharate adult stage, with Scer\GAL4eyg-22-2, eyg22-2/eygM3-12 eygScer\UAS.T:Hsim\VP16 eygmPD.mHD.Scer\UAS head | pharate adult stage (with eyg22-2) eygM3-12 head | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygmPD.mHD.Scer\UAS eygM3-12 head | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygScer\UAS.T:Hsim\VP16 eygM3-12 head | pharate adult stage (with eygM3-12) eyg22-2 head | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygmPD.mHD.Scer\UAS eyg22-2 head | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygScer\UAS.T:Hsim\VP16 eyg22-2 macrochaeta & scutum, with Scer\GAL4455.2 eygScer\UAS.cAa macrochaeta & scutum, with Scer\GAL4MD-638 eygScer\UAS.cAa macrochaeta & scutum, with Scer\GAL4MS248 eygScer\UAS.cAa macrochaeta & scutum, with Scer\GAL4pnr-MD237 eygScer\UAS.cAa macrochaeta & scutum, with Scer\GAL4ush-MD751 eygScer\UAS.cAa macrochaeta | ectopic, with Scer\GAL4MS248 eygScer\UAS.cAa mesothoracic tergum (with Df(3L)iro-2) eygSA2 eyggv5 microchaeta (with Df(3L)iro-2) eygSA2 eyggv5 microchaeta | ectopic, with Scer\GAL4455.2 eygScer\UAS.cAa microchaeta | ectopic, with Scer\GAL4ap-md544 eygScer\UAS.cAa microchaeta | ectopic, with Scer\GAL4MD-638 eygScer\UAS.cAa microchaeta | ectopic, with Scer\GAL4MS248 eygScer\UAS.cAa microchaeta | ectopic, with Scer\GAL4pnr-MD237 eygScer\UAS.cAa microchaeta | ectopic, with Scer\GAL4ush-MD751 eygScer\UAS.cAa photoreceptor cell (with Df(3L)iro-2) eyg1 retina (with Df(3L)eygC1) eyg1 retina | somatic clone eygP20MD1 salivary gland imaginal ring eygC53 scutellum, with Scer\GAL4455.2 eygScer\UAS.cAa scutellum, with Scer\GAL4ap-md544 eygScer\UAS.cAa scutellum, with Scer\GAL4MD-638 eygScer\UAS.cAa scutellum, with Scer\GAL4MS248 eygScer\UAS.cAa scutellum, with Scer\GAL4pnr-MD237 eygScer\UAS.cAa scutellum, with Scer\GAL4ush-MD751 eygScer\UAS.cAa scutum, with Scer\GAL4455.2 eygScer\UAS.cAa scutum, with Scer\GAL4MD-638 eygScer\UAS.cAa scutum, with Scer\GAL4MS248 eygScer\UAS.cAa scutum, with Scer\GAL4pnr-MD237 eygScer\UAS.cAa scutum, with Scer\GAL4ush-MD751 eygScer\UAS.cAa scutum | ectopic, with Scer\GAL4MS248 eygScer\UAS.cAa thorax eyg123M11 eyg158M26 eyg54A3 eyg76M26 eygM26 eygPxA1 thorax, with Scer\GAL4eyg-22-2 eygΔPD.Scer\UAS eygScer\UAS.T:Hsim\VP16 thorax (with eygM3-12) eygXE119 thorax (with eygXE119) eygM3-12 thorax | pharate adult stage, with Scer\GAL4eyg-22-2, eyg22-2/eygM3-12 eygΔL.ΔRED.Scer\UAS eygΔPAI.ΔL.Scer\UAS eygΔPD.Scer\UAS eygΔRED.Scer\UAS eygC.Scer\UAS eygScer\UAS.T:Hsim\VP16 eygmPD.Scer\UAS thorax | pharate adult stage (with eyg22-2) eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygC.Scer\UAS eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygmPD.Scer\UAS eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygScer\UAS.T:Hsim\VP16 eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔL.ΔRED.Scer\UAS eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔPAI.ΔL.Scer\UAS eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔPD.Scer\UAS eygM3-12 thorax | pharate adult stage (with eyg22-2), with Scer\GAL4eyg-22-2, eygΔRED.Scer\UAS eygM3-12 thorax | pharate adult stage (with eygM3-12) eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygC.Scer\UAS eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygmPD.Scer\UAS eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygScer\UAS.T:Hsim\VP16 eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔL.ΔRED.Scer\UAS eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔPAI.ΔL.Scer\UAS eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔPD.Scer\UAS eyg22-2 thorax | pharate adult stage (with eygM3-12), with Scer\GAL4eyg-22-2, eygΔRED.Scer\UAS eyg22-2 trichogen cell, with Scer\GAL4pnr-MD237 eygGD1442 wing, with Scer\GAL4MD-638 eygScer\UAS.cAa wing disc, with Scer\GAL4dpp.blk1 eyg554.Scer\UAS.T:SV40\nls2
Classical Alleles ( 28 )
For All Classical Alleles Show
Allele of eyg Class Mutagen Stocks Known lesion eygU gamma ray 3 -- eyg1 spontaneous 2 -- eygc05259 piggyBac transposase 1 -- eygc05307 piggyBac transposase 1 -- eygMB07856 1 -- eyg123M11 gene conversion 0 Yes eyg158M26 gene conversion 0 Yes eyg20MD1 P-element activity 0 Yes eyg22-2 hypomorphic allele - genetic evidence P-element activity 0 Yes eyg2 0 -- eyg37-1 P-element activity 0 Yes eyg54A3 gene conversion 0 Yes eyg64e X ray 0 -- eyg685 loss of function allele 0 -- eyg76M26 gene conversion 0 Yes eyg94-4 P-element activity 0 Yes eygc1 0 -- eygC53 0 Yes eygEq-2-d2-2 loss of function allele P-element activity 0 -- eyggv5 P-element activity 0 Yes eygM26 gene conversion 0 Yes eygM3-12 loss of function allele gamma ray 0 Yes eygP20MD1 loss of function allele P-element activity 0 Yes eygPxA1 loss of function allele P-element activity 0 Yes eygSA1 P-element activity 0 Yes eygSA2 P-element activity 0 Yes eygXE119 X ray 0 -- eygXS496 X ray 0 --
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eyg Class Mutagen Stocks Known lesion eygGD1442 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eygJF02124 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eygScer\UAS.lune in vitro construct - regulatory fusion 1 Yes eygT:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes eyg325.Scer\UAS in vitro construct - deletion 0 Yes eyg438.Scer\UAS in vitro construct - deletion 0 Yes eyg554.Scer\UAS.T:SV40\nls2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eyg554.Scer\UAS in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes eyg643.Scer\UAS in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes eyg670.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eygC.Scer\UAS antimorphic allele - genetic evidence in vitro construct - deletion 0 Yes eygen.Scer\UAS in vitro construct - coding region fusion 0 Yes eyghs.lune in vitro construct - regulatory fusion 0 Yes eyghs.PJ in vitro construct - regulatory fusion 0 Yes eygmHD.Scer\UAS in vitro construct - amino acid replacement 0 Yes eygmPD.mHD.Scer\UAS in vitro construct - amino acid replacement 0 Yes eygmPD.Scer\UAS in vitro construct - amino acid replacement 0 Yes eygNIG.10488R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes eygScer\UAS.cAa in vitro construct - regulatory fusion 0 Yes eygScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes eygScer\UAS.T:Hsim\VP16 antimorphic allele - genetic evidence in vitro construct - coding region fusion 0 Yes eygΔC.Scer\UAS in vitro construct - deletion 0 Yes eygΔHD.Scer\UAS in vitro construct - deletion 0 Yes eygΔL.ΔRED.Scer\UAS antimorphic allele - genetic evidence in vitro construct - deletion 0 Yes eygΔPAI.Scer\UAS in vitro construct - deletion 0 Yes eygΔPAI.ΔL.Scer\UAS antimorphic allele - genetic evidence in vitro construct - deletion 0 Yes eygΔPD.Scer\UAS antimorphic allele - genetic evidence in vitro construct - deletion 0 Yes eygΔRED.Scer\UAS antimorphic allele - genetic evidence in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC380 (Christensen et al., 2007.10.29) Df(3L)BSC730 (Christensen et al., 2009.2.28) Df(3L)C1 (Jones et al., 1997) Df(3L)eygC1 (Jones et al., 1998) Df(3L)iro-2 (Aldaz et al., 2003) Df(3L)iro-DFM1 (Aldaz et al., 2003) Df(3L)TP32 (Bishop et al., 1999) In(3L)C53 (Jones et al., 1997) In(3L)eygC53 (Jones et al., 1998)
Not disrupted in	Df(3L)P20 (Hoogwerf et al., 1988) Df(3L)vin2 (Hoogwerf et al., 1988) Df(3L)vin3 (Hoogwerf et al., 1988) Df(3L)vin4 (Hoogwerf et al., 1988) Df(3L)vin5 (Hoogwerf et al., 1988) Df(3L)vin6 (Hoogwerf et al., 1988) Df(3L)vin7 (Akam et al., 1978, Hoogwerf et al., 1988) Df(3L)vin8 (Hoogwerf et al., 1988) Df(3L)vin9 (Hoogwerf et al., 1988) Df(3L)vin10 (Hoogwerf et al., 1988) Df(3L)vin11 (Hoogwerf et al., 1988) Df(3L)vin66 (Hoogwerf et al., 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1442} NA P{NIG.10488R} NA P{TRiP.JF02124} NA P{UAS-eyg.325} NA P{UAS-eyg.438} NA P{UAS-eyg.554.nls} NA P{UAS-eyg.554} NA P{UAS-eyg.643} NA P{UAS-eyg.670} NA P{UAS-eyg.A} NA P{UAS-eyg.C} NA P{UAS-eyg.en} NA P{UAS-eyg.lune} NA P{UAS-eyg.mPDmHD} NA P{UAS-eyg.U} NA P{UAS-eyg.ΔC} NA P{UAS-eyg.ΔHD} NA P{UAS-eyg.ΔL.ΔRED} NA P{UAS-eyg.ΔPAI.ΔL} NA P{UAS-eyg.ΔPAI} NA P{UAS-eyg.ΔPD} NA heat-shock construct P{hs-eyg.J} NA P{hs-eyg.lune} NA GAL4 construct P{eyg.E2.Ex-Gal4} No P{wg-GAL4.eyg.B} No P{wg-GAL4.eyg.HD} No P{wg-GAL4.mPDmHD} No characterization construct P{UAS-ey::eyg.EEEGEE} NA P{UAS-ey::eyg.EEEGEG} NA P{UAS-ey::eyg.EEEGGG} NA P{UAS-ey::eyg.EEGEEE} NA P{UAS-ey::eyg.EEGEGE} NA P{UAS-ey::eyg.EEGGGE} NA P{UAS-ey::eyg.EEGGGG} NA P{UAS-ey::eyg.EGGGGE} NA P{UAS-ey::eyg.EGGGGG} NA P{UAS-ey::eyg.GEEEEE} NA P{UAS-ey::eyg.GEEEEG} NA P{UAS-ey::eyg.GGEEEE} NA P{UAS-ey::eyg.GGEEEG} NA P{UAS-ey::eyg.GGEGEG} NA P{UAS-ey::eyg.GGGEGE} NA P{UAS-ey::eyg.GGGGEG} NA P{UAS-ey::eyg.GGGGGE} NA PBac{eyg-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{3'lacW}eygP20MD1b NA PBac{PB}eygc05259 NA PBac{PB}eygc05307 NA insertion of mobile activating element P{XP}d01629d01629 NA insertion of enhancer trap binary system Mi{ET1}eygMB07856 No P{GAL4}eyggv5 No P{GawB}EM458 No P{GawB}EM461 No P{GawB}eyg22-2 No P{GawB}eyg37-1 No P{GawB}eyg54A3 No P{GawB}eyg76M26 No P{GawB}eyg94-4 No P{GawB}eyg123M11 No P{GawB}eyg158M26 No P{GawB}eygM26 No insertion of enhancer trap P{lacW}eygM3-12 No P{lacW}eygP20MD1a No P{lacW}eygPxA1a No P{lacW}eygPxA1b No P{lacZ}eyg20MD1 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
RNA polymerase II regulatory region sequence-specific DNA binding inferred from direct assay (Yao and Sun, 2005)
Biological Process
CV term Evidence References
antennal development inferred from mutant phenotype (Wang et al., 2008) compound eye development inferred from mutant phenotype (Wang et al., 2008) compound eye morphogenesis inferred from mutant phenotype (Dominguez et al., 2004, Yao and Sun, 2005) eye-antennal disc development inferred from mutant phenotype (Wang et al., 2008) eye development inferred from mutant phenotype (Jang et al., 2003) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Yao and Sun, 2005) notum development inferred from mutant phenotype (Wang et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Yao and Sun, 2005)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with mouse Pax3 (FlyBase, 1992-) non-traceable author statement (Calleja et al., 2002)
Biological Process
CV term Evidence References
salivary gland morphogenesis traceable author statement (Bradley et al., 2001)
Cellular Component
CV term Evidence References
transcription factor complex inferred from sequence or structural similarity with mouse Pax3 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eyg allele Gene References eyg1 ey (Hunt, 1970, Jang et al., 2003) H (Chao et al., 2004) N (Chao et al., 2004) os (Chao et al., 2004) pan (Hazelett et al., 1998) Ras85D (Hazelett et al., 1998) sgg (Hazelett et al., 1998) Su(H) (Chao et al., 2004) eyggv5 toe (Aldaz et al., 2003) eygM3-12 ey (Jang et al., 2003) H (Chao et al., 2004) N (Chao et al., 2004) os (Chao et al., 2004) Su(H) (Chao et al., 2004) eygScer\UAS.lune ey (Jang et al., 2003) fng (Dominguez et al., 2004) H (Chao et al., 2004) N (Dominguez et al., 2004, Chao et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64769 DroID - A comprehensive database of gene and protein interactions. • FBgn0000625 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39419
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12719 Drosophila sechellia Dsec\GM24656 Drosophila erecta Dere\GG13831 Drosophila yakuba Dyak\GE20121 Drosophila ananassae Dana\GF24979 Drosophila pseudoobscura pseudoobscura Dpse\GA10346 Drosophila persimilis Dper\GL24956 Drosophila willistoni Dwil\GK12628 Drosophila virilis Dvir\GJ13265 Drosophila mojavensis Dmoj\GI12327 Drosophila grimshawi Dgri\GH16064
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	26809 w*; P{UAS-eyg.lune}2 503 snaSco/CyO; eyg1 25574 w1118; Mi{ET1}eygMB07856 26226 y1 v1; P{TRiP.JF02124}attP2 38643 w1118; PBac{eyg-GFP.FPTB}VK00037/SM5 17700 w1118; PBac{PB}CG16884c05307/CyO; PBac{PB}eygc05307 1325 In(3L)gvU, ru1 h1 gvU eygU gl2 e4/TM3, Sb1 Ser1
Harvard	- PBac{PB}eygc05259
Kyoto	105943 eyg1 106277 In(3L)gvU, ru1 h1 gvU eygU gl2 e4/TM3, Sb1 Ser1
VDRC	v2952 w1118; P{GD1442}v2952 v2954 w1118; P{GD1442}v2954
	More stocks available...
Genomic Clones ( 2 )
	BACR26C20 BACR48G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT09010
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	RP004073786 RP004287210
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000625 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39419
Antibody Information
	polyclonal (Aldaz et al., 2003, Yao et al., 2008)
Other Information
Discoverer
	Ives, 20th July 1940.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: eyg CG10488 (Bayraktaroglu, 1999.11)
Source for database merge of
Additional comments
Other Comments
	eyg induces expression of dac. (Anderson et al., 2006) The DNA binding activity of eyg relies on the L, RED and HD domains. (Yao and Sun, 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Loss of N signaling in the eye can be compensated by overexpressing eyg, whereas loss of eyg function blocks effects of N signaling in the eye. (Chao et al., 2004) Regulation of eyg by N involves Dl and Ser and requires the activity of Su(H) but is independent of E(spl)-mediated repression of genes. (Dominguez et al., 2004) eyg is essential for eye growth but is dispensible for specification of the eye. (Dominguez et al., 2004) eyg and ey act co-operatively in promoting eye development. (Jang et al., 2003) eyg is required for embryonic salivary duct development. (Jones et al., 1998) lune is stated to be the same as eyg demonstrated by lune rescue of the eyg mutant phenotype. There are no mutations of lune so allelism cannot be tested. (Jones, 1997.4.17) Most metazoan homeodomains share a preference for the TAAT motif, they can differ from each other in their preference for the bases immediately 3' to this core. This preference is determined, in part, by the identity of amino acid position 50. Because homeodomain sequences have been identified that possess at least 10 different amino acids at position 50 it is investigated whether multiple DNA binding specificities can be conferred by changing this position to a variety of amino acid side chains. (Wilson et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079318 NM_001014582 RefSeq (Proteins) • NP_524042 NP_001014582 DDBJ / EMBL / GenBank • AAC78330 AAF49918 AAF49918.2 AAM43805 AAN87345 AAN87346 AAX33618 AAX52747 AAY82192 AAY82193 AF091739 AY099362 AY167573 AY167574 BT021470 CZ469827 DQ017410 DQ017411 Entrez Gene - A searchable database of RefSeq genes. • 39419 UniProtKB/TrEMBL • O77238 Q3YNE2 Q5BHV4 Q7YSG8 Q8MTJ1 Q9VTX7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Paired domain (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT09010
Linkouts
	BioGRID - A database of protein and genetic interactions • 64769 DroID - A comprehensive database of gene and protein interactions. • FBgn0000625 DRSC - Results from RNAi screens. • FBgn0000625 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000625 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10488-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000625 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39419 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/eyegon1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39419 modMine - Data generated by the modENCODE project. • FBgn0000625
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	Bk27 (Wilson et al., 1996) BK27 (Wilson et al., 1996, ) CG10488 (Datta et al., 2011, Perkins et al., 2009.3.31) eyg (Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Datta, 2007, Sato and Tomlinson, 2007, Roignant et al., 2010, Roederer et al., 2005, Salvany et al., 2007, Anderson et al., 2006, Luque and Milan, 2007, Duong et al., 2008, Christensen et al., 2007.10.29, de Navascués and Modolell, 2007, Estella and Mann, 2010, Moberg et al., 2005, Chattopadhyay et al., 2008, Wang and Sun, 2008, Anderson and Kumar, 2008, Datta et al., 2011, Kankel et al., 2007, Devineni et al., 2011, Bao and Friedrich, 2009, Jiang et al., 2009, Rusten et al., 2006, Yao et al., 2008, Christensen et al., 2009.2.28, Wang et al., 2008, Dworkin et al., 2009, Wang and Huang, 2009, Brás-Pereira and Casares, 2008, Grieder et al., 2009, Martinez et al., 2009, Gutierrez-Aviño et al., 2009, Wang et al., 2010, Spokony and White, 2012.5.22, Blanco et al., 2010, Salzer et al., 2010, Chatterjee et al., 2011, Brown and Feder, 2005, Chopra et al., 2011, Classen et al., 2009, Friedrich and Caravas, 2011, Vallejo et al., 2011, Del Signore et al., 2012, McNeil et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Eyg (Ekas et al., 2006, Wang et al., 2007, Lu and Bilder, 2005, Tsai et al., 2008, Grieder et al., 2007, Estella and Mann, 2010, Lee et al., 2009, Maybeck and Röper, 2009, Raja et al., 2010, de Navascués and Modolell, 2010) EYG (Prince et al., 2008) lun (Sun et al., 1997, )
Name Synonym	eye gone (Jang and Sun, 2001, Roederer et al., 2005, Wang and Sun, 2008, Wang et al., 2010) eyegone (Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Datta, 2007, Roignant et al., 2010, Fernald, 2006, Luque and Milan, 2007, Estella and Mann, 2010, Chattopadhyay et al., 2008, Kankel et al., 2007, Rusten et al., 2006, Yao et al., 2008, Protzer et al., 2008, Brás-Pereira and Casares, 2008, Grieder et al., 2009, Blanco et al., 2010, Chatterjee et al., 2011, Chopra et al., 2011, Friedrich and Caravas, 2011) Eyegone (Ekas et al., 2006, Sato and Tomlinson, 2007, Tsai et al., 2008, Bao and Friedrich, 2009) eyeone (Martinez et al., 2009) Eygone (Estella and Mann, 2010, Grieder et al., 2007) eygone (Vallejo et al., 2011) lune (Jones et al., 1997, Jones, 1997.4.17, )
Secondary FlyBase IDs
	FBgn0011647
References ( 159 )
Generate a list of	All references relating to this gene ( 159 )
List References by type	Research paper  ( 76 ) Supplementary material  ( 5 ) Review  ( 16 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 42 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 11 )
	Del Signore et al., 2012, Mech. Dev. 129(5-8): 147--161 odd-skipped genes and lines organize the notum anterior-posterior axis using autonomous and non-autonomous mechanisms. [FBrf0219018] Salvany et al., 2012, Mol. Cell. Biol. 32(13): 2407--2415 Functional Association between Eyegone and HP1a Mediates wingless Transcriptional Repression during Development. [FBrf0218589] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Chopra et al., 2011, Mol. Cell 42(6): 837--844 The Polycomb Group Mutant esc Leads to Augmented Levels of Paused Pol II in the Drosophila Embryo. [FBrf0214009] Datta et al., 2011, Evol. Dev. 13(1): 58--71 Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs. [FBrf0212714] Devineni et al., 2011, Fly 5(3): 191--199 The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. [FBrf0214716] Friedrich and Caravas, 2011, J. Exp. Zool. B Mol. Dev. Evol. 316(6): 387--392 New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone. [FBrf0214613] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] McNeil et al., 2011, G3 (Bethesda) 1(5): 343--351 Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. [FBrf0217624] Vallejo et al., 2011, EMBO J. 30(4): 756--769 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. [FBrf0213063] Yorimitsu et al., 2011, Dev. Biol. 356(2): 598--607 Defective proventriculus specifies the ocellar region in the Drosophila head. [FBrf0214458] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...