• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\E(z)

General Information
Symbol	Dmel\E(z)	Species	D. melanogaster
Name	Enhancer of zeste	Annotation symbol	CG6502
Feature type	protein_coding_gene	FlyBase ID	FBgn0000629
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	EZ, pco, Su(z)301, l(3)1902, E(z)1
Genomic Location
Chromosome (arm)	3L	Recombination map	3-34.0
Cytogenetic map	67E5-67E5	Sequence location	3L:10,627,675..10,631,230 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Enhancer of zeste is referred to in FlyBase by the symbol Dmel\E(z) (CG6502, FBgn0000629). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone methyltransferase activity (H3-K27 specific); protein binding; histone methyltransferase activity (H3-K9 specific); histone methyltransferase activity. There is experimental evidence that it is involved in the biological process: histone methylation; axon guidance; histone H3-K27 methylation; cuticle hydrocarbon biosynthetic process; dendrite morphogenesis; histone H3-K9 methylation; muscle organ development; syncytial blastoderm mitotic cell cycle; neurogenesis. 115 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; thoracic segment; imaginal precursor; dorsal thoracic disc; female germline cyst; larval thorax; adult abdominal segment; somatic cell; egg; embryonic/larval imaginal precursor; cell cycle; adult metathoracic segment; adult mesothoracic segment; adult external prothorax. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: SANT domain, DNA binding; SET domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626696_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of E(z). Gene sequence location is 3L:10627675..10631230.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	E(z): Enhancer of zeste Locus named after original gain-of-function allele E(z)1 (Kalisch and Rasmuson); subsequently designated polycombeotic (pco) (by Phillips and Shearn) based on phenotype of lethal homozygotes. Loss of function alleles recovered as (a) recessive lethal mutations (b) reversions of E(z)1 and (c) reversions of the antimorphic allele, E(z)59. Reduction of E(z)+ activity leads to suppression of the z eye color, whereas gain-of-function alleles are dominant enhancers of zeste eye color [i.e., z w+/Y; E(z)1/+ males have brownish eyes as do z w+/z+ w+; E(z)1/+ females]. E(z)59 an antimorphic allele, is a dominant suppressor of z [i.e. z w+; E(z)59/+ females have orange eyes]. Hemizygosity for E(z)+ produces a very mild suppression of the z eye color. No effects on eye color in z+ or za backgrounds, and effects on eye color not specific to a particular w allele. Reduction of E(z)+ activity also allows ectopic expression of the segment identity genes of the Antennapedia and bithorax gene complexes, resulting in homeotic transformations. This latter effect defines E(z) as a Polycomb-group locus. E(z)61 displays temperature-sensititive suppression of z eye color and homeotic phenotypes. At 22, z wis/Y; E(z)61/Df(3L)E(z)-males have orange eyes and no homeotic transformations. At 29, such males have wild-type red eyes and die as pharate adults with strong homeotic transformations of the mesothoracic and metathoracic legs toward the prothoracic state. Embryos produced by E(z)61 homozygous females at 29C die with homeotic transformations of most segments toward the eighth abdominal segment. Even two copies of paternally contributed E(z)+ does not rescue viability of these embryos. Complete lack of zygotically produced E(z)+ results in early pupal lethality and small imaginal disks. Larval brain squashes from individuals homozygous for an amorphic allele reveal a very low mitotic index; metaphase chromosomes irregularly condensed and fragmented (Gatti and Baker, 1989, Genes Dev. 3: 438-53).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Margueron et al., 2009, Nature 461(7265): 762--767
FB2012_01	Sequence features HFA11147 BKN22825 References Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 Riddle et al., 2011, Genome Res. 21(2): 147--163 Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Guertin and Lis, 2010, PLoS Genet. 6(9):
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67E5-67E5   Limits computationally determined from genome sequence between P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562 and P{PZ}simj01814
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67E3-67E4   (determined by in situ hybridisation)   (Phillips and Shearn, 1993)
Experimentally Determined Recombination Data
Location	3-30.9 +/- 0.7 (Shearn et al., 1978) 3-30.9 (Gatti and Baker, 1989) 3-34.0   3-34.25 +/- 0.5 (Bajusz et al., 2001)
Left of (cM)
Right of (cM)
Notes	Genetic map position contradicts cytological map position.
Gene Model & Products
Please see the GBrowse view of Dmel\E(z) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) E(z)-RA FBtr0076279  NM_079297   2650   760 E(z)-RB FBtr0273338  NM_001144460   2463   760
Additional Transcript Data & Comments
Reported size (kB)	3.3, 2.5 (northern blot) (Jones and Gelbart, 1993) 2.5 (northern blot) (Mounkes et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein E(z)-PA   FBpp0076008   86.9   760   6.29     NP_524021   AAF50149 E(z)-PB   FBpp0271846   86.9   760   6.29     NP_001137932   ACL83287
Additional Polypeptide Data & Comments
Reported size (kDa)	760 (aa); 87 (kD predicted) (Jones and Gelbart, 1993) 89 (kD observed) (Carrington and Jones, 1996)
Comments	E(z) protein was found to bind to 44 identified sites along the polytene chromosomes. (Carrington and Jones, 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SANT domain, DNA binding (IPR001005) SET domain (IPR001214)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439938   AA978408   AE014296 AAF50149   AE014296 ACL83287   AW943033   AY051785 AAK93209   BF491255   BF494501   BI230871   BI234676   BI242049   BI353359   BI368539   BP542552   CO190441   CO307721   CO314017   EC065342   EC226496   EC247228   EV579427   GH941890   GH942015   GH944774   GH946756   GH949152   GH950058   GH952419   GH953883   GH956530   GH961321   GH961846   GH967456   GH968668   GH970517   GH978178   GH979775   GH982816   GH983219   U00180 AAC46462
UniProtKB/Swiss-Prot	P42124
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References insertion site H{}E(z)[60] 3L:10,628,520..10,628,522 evidence=experimental comment=The insertion site maps to codon 523; E(z)60 encodes a C-terminally truncated protein that lacks amino acids 524 to 760. The orientation of the insertion was not reported. (Carrington and Jones, 1996)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Jones and Gelbart, 1993) larval stage & pupal stage     (Jones and Gelbart, 1993) adult stage | male     (Jones and Gelbart, 1993)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Carrington and Jones, 1996) third instar larval stage   organism | ubiquitous   (Carrington and Jones, 1996)
Additional Descriptive Data
	E(z) protein is uniformly distributed in embryos. It is ubiquitously distributed in larvae at lower levels. (Carrington and Jones, 1996)
Marker for
Subcellular Localization
CV Term	nucleus polytene chromosome (Carrington and Jones, 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000629    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000629 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000629 expression level Developmental Stage   Expression Level embryo 00-02hr    3314 embryo 02-04hr    1806 embryo 04-06hr    4164 embryo 06-08hr    2745 embryo 08-10hr    2041 embryo 10-12hr    1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day    1638 adult female 05day    2404 adult female 30day    2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3314) embryo 02-04hr  (1806) embryo 04-06hr  (4164) embryo 06-08hr  (2745) embryo 08-10hr  (2041) embryo 10-12hr  (1444) embryo 12-14hr  (1239) embryo 14-16hr  (1050) embryo 16-18hr  (887) embryo 18-20hr  (710) embryo 20-22hr  (738) embryo 22-24hr  (822) larva L1  (1393) larva L2  (994) larva L3 12hr old  (753) larva L3 puffstage 1-2  (892) larva L3 puffstage 3-6  (999) larva L3 puffstage 7-9  (1178) white prepupae new  (1185) white prepupae 12hr  (1268) white prepupae 24hr  (1333) pupae 2d postWPP  (966) pupae 3d postWPP  (722) pupae 4d postWPP  (598) adult male 01day  (732) adult male 05day  (809) adult male 30day  (960) adult female 01day  (1638) adult female 05day  (2404) adult female 30day  (2305) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3314) embryo 02-04hr  (1806) embryo 04-06hr  (4164) embryo 06-08hr  (2745) embryo 08-10hr  (2041) embryo 10-12hr  1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day  (1638) adult female 05day  (2404) adult female 30day  (2305) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3314 embryo 02-04hr    1806 embryo 04-06hr    4164 embryo 06-08hr    2745 embryo 08-10hr    2041 embryo 10-12hr    1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day    1638 adult female 05day    2404 adult female 30day    2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3314 embryo 02-04hr    1806 embryo 04-06hr    4164 embryo 06-08hr    2745 embryo 08-10hr    2041 embryo 10-12hr    1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day    1638 adult female 05day    2404 adult female 30day    2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000629 expression level Developmental Stage   Expression Level embryo 00-02hr    3314 embryo 02-04hr    1806 embryo 04-06hr    4164 embryo 06-08hr    2745 embryo 08-10hr    2041 embryo 10-12hr    1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day    1638 adult female 05day    2404 adult female 30day    2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3314) embryo 02-04hr  (1806) embryo 04-06hr  (4164) embryo 06-08hr  (2745) embryo 08-10hr  (2041) embryo 10-12hr  (1444) embryo 12-14hr  (1239) embryo 14-16hr  (1050) embryo 16-18hr  (887) embryo 18-20hr  (710) embryo 20-22hr  (738) embryo 22-24hr  (822) larva L1  (1393) larva L2  (994) larva L3 12hr old  (753) larva L3 puffstage 1-2  (892) larva L3 puffstage 3-6  (999) larva L3 puffstage 7-9  (1178) white prepupae new  (1185) white prepupae 12hr  (1268) white prepupae 24hr  (1333) pupae 2d postWPP  (966) pupae 3d postWPP  (722) pupae 4d postWPP  (598) adult male 01day  (732) adult male 05day  (809) adult male 30day  (960) adult female 01day  (1638) adult female 05day  (2404) adult female 30day  (2305) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3314) embryo 02-04hr  1806 embryo 04-06hr  (4164) embryo 06-08hr  (2745) embryo 08-10hr  2041 embryo 10-12hr  1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day  1638 adult female 05day  2404 adult female 30day  2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3314 embryo 02-04hr    1806 embryo 04-06hr    4164 embryo 06-08hr    2745 embryo 08-10hr    2041 embryo 10-12hr    1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day    1638 adult female 05day    2404 adult female 30day    2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3314 embryo 02-04hr    1806 embryo 04-06hr    4164 embryo 06-08hr    2745 embryo 08-10hr    2041 embryo 10-12hr    1444 embryo 12-14hr    1239 embryo 14-16hr    1050 embryo 16-18hr    887 embryo 18-20hr    710 embryo 20-22hr    738 embryo 22-24hr    822 larva L1    1393 larva L2    994 larva L3 12hr old    753 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    999 larva L3 puffstage 7-9    1178 white prepupae new    1185 white prepupae 12hr    1268 white prepupae 24hr    1333 pupae 2d postWPP    966 pupae 3d postWPP    722 pupae 4d postWPP    598 adult male 01day    732 adult male 05day    809 adult male 30day    960 adult female 01day    1638 adult female 05day    2404 adult female 30day    2305 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000629    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000629 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000629 expression level Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000629 expression level Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    141.5 Larval Midgut    29.8 Larval Hindgut    36.5 Larval Malpighian Tubules    73.8 Larval Fat Body    51.4 Larval Salivary Gland    88.8 Larval Trachea    76.725 Larval Carcass    40.95 Adult Head    41 Adult Eye    49.7 Adult Brain    87.5 Adult Thoracic-Abdominal Ganglion    65.6 Adult Crop    44.1 Adult Midgut    49.5 Adult Hindgut    44.2 Adult Malpighian Tubules    66.5 Adult Fat Body    31 Adult Salivary Gland    69.1 Adult Heart    38.325 Adult VirginFemale Spermatheca    45.9 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    183.4 Adult Testis    32.6 Adult Male Accessory Gland    69.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    41   NA  Eye    49.7   NA  Brain    87.5   141.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    65.6   NA  Crop    44.1   29.8  Midgut    49.5   36.5  Hindgut    44.2   73.8  Malpighian Tubules    66.5   51.4  Fat Body    31   88.8  Salivary Gland    69.1   NA  Heart    38.325   76.725  Trachea    NA   NA  VirginFemale Spermatheca    45.9   NA  InseminatedFemale Spermatheca    50.5   NA  Ovary    183.4   NA  Testis    32.6   NA  Male Accessory Gland    69.5   40.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000629 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6502-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for E(z) Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | heat sensitive E(z)61 lethal | heat sensitive E(z)12 E(z)32 E(z)61 lethal | larval stage | recessive E(z)5 E(z)son1 E(z)son2 E(z)son3 lethal | maternal effect | recessive | heat sensitive E(z)28 E(z)32 lethal | pharate adult stage (with In(3L)Ez2) E(z)Trm lethal | pharate adult stage | recessive E(z)14 E(z)Trm lethal | recessive E(z)1 E(z)2 E(z)3 E(z)4 E(z)5 E(z)6 E(z)8 E(z)9 E(z)10 E(z)11 E(z)12 E(z)13 E(z)14 E(z)15 E(z)16 E(z)17 E(z)18 E(z)19 E(z)20 E(z)21 E(z)22 E(z)23 E(z)24 E(z)25 E(z)26 E(z)27 E(z)29 E(z)30 E(z)31 E(z)32 E(z)33 E(z)34 E(z)35 E(z)36 E(z)37 E(z)38 E(z)39 E(z)40 E(z)41 E(z)42 E(z)43 E(z)44 E(z)45 E(z)46 E(z)47 E(z)48 E(z)49 E(z)50 E(z)51 E(z)52 E(z)53 E(z)54 E(z)55 E(z)56 E(z)57 E(z)58 E(z)59 E(z)60 E(z)61 E(z)62 E(z)63 E(z)64 E(z)65 E(z)66 E(z)67 E(z)68 E(z)69 E(z)70 E(z)71 E(z)72 E(z)73 E(z)74 E(z)75 lethal | recessive | heat sensitive E(z)28 E(z)61 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 E(z)GD11942 viable (with E(z)32) E(z)61 viable (with E(z)60) E(z)Trm viable (with E(z)61) E(z)32 viable (with E(z)son1) E(z)Trm viable (with E(z)son2) E(z)Trm viable (with E(z)son3) E(z)Trm viable (with E(z)Trm) E(z)60 E(z)son1 E(z)son2 E(z)son3 Sterility Allele female sterile | recessive E(z)12 female sterile | recessive | heat sensitive E(z)28 fertile | poor E(z)Trm Other Phenotypes Allele decreased cell number | somatic clone E(z)731 eye color defective E(z)1 E(z)60 mitotic cell cycle defective E(z)5 mitotic cell cycle defective | embryonic stage E(z)63 E(z)66 mitotic cell cycle defective | recessive E(z)5 mitotic cell cycle defective | somatic clone E(z)731 neuroanatomy defective | somatic clone E(z)63 E(z)731 non-enhancer of variegation, with P{hsp26-pt-T}39C-5 E(z)5 non-suppressor of variegation, with P{hsp26-pt-T}39C-5 E(z)5 non-suppressor of variegation | dominant, with P{RS3}panCB-5204-3 E(z)5 non-suppressor of variegation | dominant, with P{RS5}5-HA-1902 E(z)5 non-suppressor of variegation | dominant, with P{RS5}5-HA-1992 E(z)5 non-suppressor of variegation | dominant, with T(2;3)V21-P{lacW}92E.x3 E(z)5 suppressor of variegation | dominant, with In(1)wm4 E(z)5 visible, with Scer\GAL4pnr-MD237 E(z)GD11942 visible | dominant E(z)Trm visible | dominant | homeotic E(z)60 visible | homeotic (with E(z)32) E(z)61 visible | homeotic (with E(z)61) E(z)32 visible | recessive E(z)5 E(z)12 E(z)14 visible | recessive | heat sensitive E(z)28 E(z)61 visible | somatic clone E(z)32A40 E(z)32B20 E(z)33D9 E(z)33H25 E(z)33M23 E(z)33M30 E(z)33Z14 E(z)143 E(z)328 E(z)731 E(z)914 E(z)1025 E(z)2434 wild-type E(z)+t8.8 E(z)T:Zzzz\FLAG Phenotype manifest in Allele adult abdominal segment 4 | ectopic E(z)Trm adult abdominal segment 4 | ectopic (with E(z)60) E(z)Trm adult abdominal segment 4 | ectopic (with E(z)Trm) E(z)60 adult abdominal segment 4 | ectopic (with In(3L)Ez2) E(z)Trm adult abdominal segment 5 E(z)Trm adult abdominal segment 5 (with E(z)60) E(z)Trm adult abdominal segment 5 (with E(z)Trm) E(z)60 adult abdominal segment 5 (with In(3L)Ez2) E(z)Trm adult abdominal segment 5 | ectopic E(z)Trm adult abdominal segment 5 | ectopic (with In(3L)Ez2) E(z)Trm adult abdominal segment 6 E(z)Trm adult abdominal segment 6 (with In(3L)Ez2) E(z)Trm adult abdominal segment 6 | ectopic E(z)Trm adult abdominal segment 6 | ectopic (with In(3L)Ez2) E(z)Trm adult abdominal segment 7 E(z)Trm adult abdominal segment 7 (with In(3L)Ez2) E(z)Trm adult mesothoracic segment | ectopic E(z)Trm adult mesothoracic segment | ectopic (with E(z)60) E(z)Trm adult mesothoracic segment | ectopic (with E(z)son2) E(z)Trm adult mesothoracic segment | ectopic (with E(z)Trm) E(z)60 E(z)son2 adult metathoracic segment E(z)Trm adult metathoracic segment (with E(z)60) E(z)Trm adult metathoracic segment (with E(z)son2) E(z)Trm adult metathoracic segment (with E(z)Trm) E(z)60 E(z)son2 adult prothoracic segment E(z)Trm adult prothoracic segment (with E(z)60) E(z)Trm adult prothoracic segment (with E(z)Trm) E(z)60 axon | somatic clone E(z)731 cell cycle E(z)5 CNS glial cell | ectopic | somatic clone E(z)731 dendrite & dorsal multidendritic neuron ddaC | somatic clone E(z)63 egg E(z)12 egg chamber E(z)12 eye | somatic clone E(z)T643 eye-antennal disc E(z)5 eye disc | somatic clone E(z)T643 female genitalia | ventral E(z)Trm genital disc E(z)5 haltere E(z)Trm haltere disc E(z)5 E(z)61 humerus E(z)Trm imaginal disc E(z)5 imaginal disc | heat sensitive E(z)12 larval abdominal segment 1 | maternal effect | heat sensitive E(z)32 larval abdominal segment 2 | maternal effect | heat sensitive E(z)32 larval abdominal segment 3 | maternal effect | heat sensitive E(z)32 larval abdominal segment 4 | maternal effect | heat sensitive E(z)32 larval abdominal segment 5 | maternal effect | heat sensitive E(z)32 larval abdominal segment 6 | maternal effect | heat sensitive E(z)32 larval abdominal segment 7 | maternal effect | heat sensitive E(z)32 larval abdominal segment 8 | maternal effect | heat sensitive E(z)32 larval abdominal segment 9 | maternal effect | heat sensitive E(z)32 larval abdominal segment 10 | maternal effect | heat sensitive E(z)32 larval abdominal segment 11 | maternal effect | heat sensitive E(z)32 larval brain & mitosis & nuclear chromosome E(z)5 larval thorax | maternal effect | heat sensitive E(z)32 leg E(z)14 leg | ectopic E(z)Trm male genitalia | ventral E(z)Trm mesothoracic leg E(z)12 E(z)28 E(z)5 E(z)60 mesothoracic leg & sex comb | ectopic E(z)60 mesothoracic tergum, with Scer\GAL4pnr-MD237 E(z)GD11942 metaphase & condensed chromosome & embryo E(z)63 E(z)66 metathoracic leg E(z)12 E(z)28 E(z)5 morphogenetic furrow | somatic clone E(z)T643 neuroblast | somatic clone E(z)731 nurse cell E(z)12 nurse cell | maternal effect | heat sensitive E(z)28 photoreceptor cell | somatic clone E(z)T643 pigment cell E(z)1 E(z)2 E(z)3 E(z)4 E(z)60 polytene chromosome | heat sensitive E(z)61 segment | heat sensitive E(z)61 sex comb E(z)60 E(z)Trm sex comb | ectopic E(z)60 E(z)son2 tergite | ectopic E(z)Trm triple row | ectopic E(z)Trm ventral thoracic disc E(z)5 wing | ectopic E(z)Trm wing | posterior compartment E(z)Trm wing | somatic clone E(z)1025 E(z)2434 E(z)328 E(z)731 E(z)32A40 E(z)32B20 E(z)33D9 E(z)33H25 E(z)33M23 E(z)33M30 E(z)33Z14 E(z)143 E(z)914 wing disc E(z)61 wing disc | somatic clone E(z)63
Classical Alleles ( 101 )
For All Classical Alleles Show
Allele of E(z) Class Mutagen Stocks Known lesion E(z)731 ethyl methanesulfonate 1 Yes E(z)EY21318 P-element activity 1 -- E(z)G4251 P-element activity 1 -- E(z)5 loss of function allele, amorphic allele - genetic evidence, gain of function allele N-methyl-N'-nitro-N-nitrosoguanidine 0 -- E(z)63 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes E(z)64 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- E(z)65 amorphic allele - genetic evidence, loss of function allele gamma ray 0 Yes E(z)68 loss of function allele, amorphic allele - genetic evidence gamma ray 0 -- E(z)74 amorphic allele - genetic evidence, loss of function allele gamma ray 0 -- E(z)75 amorphic allele - genetic evidence, loss of function allele gamma ray 0 -- E(z)su4 amorphic allele - genetic evidence 0 -- E(z)1025 ethyl methanesulfonate 0 Yes E(z)10 loss of function allele ethyl methanesulfonate 0 -- E(z)11 loss of function allele ethyl methanesulfonate 0 -- E(z)12 loss of function allele ethyl methanesulfonate 0 -- E(z)13 loss of function allele ethyl methanesulfonate 0 -- E(z)143 ethyl methanesulfonate 0 -- E(z)14 loss of function allele ethyl methanesulfonate 0 -- E(z)15 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- E(z)16 loss of function allele ethyl methanesulfonate 0 -- E(z)17 loss of function allele ethyl methanesulfonate 0 -- E(z)18 loss of function allele ethyl methanesulfonate 0 -- E(z)19 loss of function allele ethyl methanesulfonate 0 -- E(z)1 neomorphic allele - genetic evidence, antimorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 0 -- E(z)20 loss of function allele ethyl methanesulfonate 0 -- E(z)21 loss of function allele ethyl methanesulfonate 0 -- E(z)22 loss of function allele ethyl methanesulfonate 0 -- E(z)23 loss of function allele ethyl methanesulfonate 0 -- E(z)2434 ethyl methanesulfonate 0 Yes E(z)24 loss of function allele ethyl methanesulfonate 0 -- E(z)25 loss of function allele ethyl methanesulfonate 0 -- E(z)26 loss of function allele ethyl methanesulfonate 0 -- E(z)27 loss of function allele ethyl methanesulfonate 0 -- E(z)28 loss of function allele ethyl methanesulfonate 0 Yes E(z)29 loss of function allele ethyl methanesulfonate 0 -- E(z)2 ethyl methanesulfonate 0 -- E(z)30 loss of function allele ethyl methanesulfonate 0 -- E(z)31 loss of function allele ethyl methanesulfonate 0 -- E(z)328 ethyl methanesulfonate 0 Yes E(z)32 loss of function allele ethyl methanesulfonate 0 Yes E(z)32A40 ethyl methanesulfonate 0 -- E(z)32B20 ethyl methanesulfonate 0 -- E(z)33 loss of function allele ethyl methanesulfonate 0 -- E(z)33D9 ethyl methanesulfonate 0 -- E(z)33H25 ethyl methanesulfonate 0 -- E(z)33M23 ethyl methanesulfonate 0 -- E(z)33M30 ethyl methanesulfonate 0 -- E(z)33Z14 ethyl methanesulfonate 0 -- E(z)34 loss of function allele ethyl methanesulfonate 0 -- E(z)35 loss of function allele ethyl methanesulfonate 0 -- E(z)36 loss of function allele ethyl methanesulfonate 0 -- E(z)37 loss of function allele ethyl methanesulfonate 0 -- E(z)38 loss of function allele ethyl methanesulfonate 0 -- E(z)39 loss of function allele ethyl methanesulfonate 0 -- E(z)3 ethyl methanesulfonate 0 -- E(z)40 loss of function allele ethyl methanesulfonate 0 -- E(z)41 loss of function allele ethyl methanesulfonate 0 -- E(z)42 loss of function allele ethyl methanesulfonate 0 -- E(z)43 loss of function allele ethyl methanesulfonate 0 -- E(z)44 loss of function allele ethyl methanesulfonate 0 -- E(z)45 loss of function allele ethyl methanesulfonate 0 -- E(z)46 loss of function allele ethyl methanesulfonate 0 -- E(z)47 loss of function allele ethyl methanesulfonate 0 -- E(z)48 loss of function allele ethyl methanesulfonate 0 -- E(z)49 loss of function allele ethyl methanesulfonate 0 -- E(z)4 ethyl methanesulfonate 0 -- E(z)50 loss of function allele ethyl methanesulfonate 0 -- E(z)51 loss of function allele ethyl methanesulfonate 0 -- E(z)52 loss of function allele ethyl methanesulfonate 0 -- E(z)53 loss of function allele ethyl methanesulfonate 0 -- E(z)54 loss of function allele ethyl methanesulfonate 0 -- E(z)55 loss of function allele ethyl methanesulfonate 0 -- E(z)56 loss of function allele ethyl methanesulfonate 0 -- E(z)57 loss of function allele ethyl methanesulfonate 0 -- E(z)58 loss of function allele ethyl methanesulfonate 0 -- E(z)59 loss of function allele ethyl methanesulfonate 0 -- E(z)60 antimorphic allele - genetic evidence, gain of function allele ethyl methanesulfonate 0 Yes E(z)61 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes E(z)62 antimorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 -- E(z)66 antimorphic allele - genetic evidence, loss of function allele gamma ray 0 Yes E(z)67 loss of function allele gamma ray 0 -- E(z)69 loss of function allele gamma ray 0 -- E(z)6 loss of function allele ethyl methanesulfonate 0 -- E(z)70 loss of function allele gamma ray 0 -- E(z)71 loss of function allele gamma ray 0 -- E(z)72 loss of function allele gamma ray 0 -- E(z)73 loss of function allele gamma ray 0 -- E(z)7 ethyl methanesulfonate 0 -- E(z)8 loss of function allele ethyl methanesulfonate 0 -- E(z)914 ethyl methanesulfonate 0 -- E(z)9 loss of function allele ethyl methanesulfonate 0 -- E(z)E4G.2 ethyl methanesulfonate 0 Yes E(z)son1 antimorphic allele - genetic evidence ethyl methanesulfonate 0 -- E(z)son2 antimorphic allele - genetic evidence ethyl methanesulfonate 0 -- E(z)son3 antimorphic allele - genetic evidence ethyl methanesulfonate 0 -- E(z)su301 hypomorphic allele - genetic evidence 0 -- E(z)T643 ethyl methanesulfonate 0 -- E(z)Trm gain of function allele 0 Yes E(z)TrmTG 0 Yes E(z)ts 0 -- E(z)unspecified 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of E(z) Class Mutagen Stocks Known lesion E(z)GD11942 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes E(z)GL00486 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes E(z)HMS00066 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes E(z)JF01402 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes E(z)JF02826 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes E(z)KK102729 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes E(z)+t8.8 in vitro construct - genomic fragment 0 Yes E(z)A in vitro construct - genomic fragment 0 Yes E(z)c.hs in vitro construct - regulatory fusion 0 Yes E(z)g.hs in vitro construct - regulatory fusion 0 Yes E(z)H730K.hs in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes E(z)NIG.6502R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes E(z)R699H.hs in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes E(z)T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)E(z)66 (Mounkes et al., 1992, Jones and Gelbart, 1993) Df(3L)lxd6 (Phillips and Shearn, 1990) Df(3L)lxd15 (Phillips and Shearn, 1990) In(3L)Ez2 (Bajusz et al., 2001, Carrington and Jones, 1996) T(2;3)E(z)65 (Mounkes et al., 1992) Tp(3;3)UbxP20 (Phillips and Shearn, 1990)
Duplicated in	Dp(3;3)UbxP20 (Phillips and Shearn, 1990)
Not disrupted in	Df(3L)vin2 (Phillips and Shearn, 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-E(z)H730K} NA P{hs-E(z)R699H} NA P{hs-E(z)cDNA} NA P{hs-E(z)genomic} NA UAS construct P{GD11942} NA P{KK102729} NA P{TRiP.GL00486} NA P{TRiP.HMS00066} NA P{TRiP.JF01402} NA P{TRiP.JF02826} NA characterization construct P{E(z)B} NA P{FLAG-E(z).W} NA P{hayA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions H{}E(z)60 NA insertion of mobile activating element P{EP}E(z)G4251 NA P{EPgy2}E(z)EY21318 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
histone methyltransferase activity inferred from direct assay (Joshi et al., 2008) inferred from mutant phenotype (Czermin et al., 2002) contributes_to histone methyltransferase activity inferred from direct assay (Ohno et al., 2008, Ketel et al., 2005) histone methyltransferase activity (H3-K9 specific) inferred from direct assay (Czermin et al., 2002) histone methyltransferase activity (H3-K27 specific) inferred from direct assay (Muller et al., 2002, Czermin et al., 2002) inferred from mutant phenotype (Joshi et al., 2008) contributes_to histone methyltransferase activity (H3-K27 specific) inferred from mutant phenotype (Ketel et al., 2005) protein binding inferred from physical interaction with Pcl (assigned by UniProtKB) (Tie et al., 2003) inferred from physical interaction with UniProtKB:P41046 (assigned by UniProtKB) (Salvaing et al., 2003)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Wang et al., 2006) cuticle hydrocarbon biosynthetic process inferred from mutant phenotype (Wicker-Thomas and Jallon, 2000) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) histone H3-K9 methylation inferred from direct assay (Czermin et al., 2002) histone H3-K27 methylation inferred from direct assay (Czermin et al., 2002) inferred from mutant phenotype (Joshi et al., 2008) histone methylation inferred from direct assay AND inferred from mutant phenotype (Muller et al., 2002) inferred from mutant phenotype (Czermin et al., 2002) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) neurogenesis inferred from mutant phenotype (Bello et al., 2007) syncytial blastoderm mitotic cell cycle inferred from mutant phenotype (O'Dor et al., 2006)
Cellular Component
CV term Evidence References
ESC/E(Z) complex inferred from direct assay (Muller et al., 2002, Czermin et al., 2002, Ohno et al., 2008) histone methyltransferase complex inferred from direct assay (Ketel et al., 2005) nucleus inferred from direct assay (Tie et al., 2001, Czermin et al., 2002)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001005 (FlyBase Curators et al., 2004-) histone methyltransferase activity (H3-K27 specific) traceable author statement (Simms et al., 2003, Heinkoff et al., 2004)
Biological Process
CV term Evidence References
chromatin silencing non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) histone methylation traceable author statement (Simms et al., 2003, Heinkoff et al., 2004) pheromone metabolic process non-traceable author statement (Wicker and Jallon, 1995)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions E(z) allele Gene References E(z)1 ash1 (LaJeunesse and Shearn, 1996) w (Erhardt et al., 2003) z (Kalisch and Rasmuson, 1974, Jones and Gelbart, 1990) E(z)2 z (Kalisch and Rasmuson, 1974) E(z)3 z (Kalisch and Rasmuson, 1974) E(z)4 z (Kalisch and Rasmuson, 1974) E(z)5 ash1 (LaJeunesse and Shearn, 1996, Gildea et al., 2000) E(z)32 Sir2 (Furuyama et al., 2004) E(z)60 corto (Kodjabachian et al., 1998) ct (Melnikova et al., 1996) dom (Ruhf et al., 2001) mxc (Docquier et al., 1996, Saget et al., 1998) Snr1 (Marenda et al., 2004) Su(var)2-1 (Bajusz et al., 2001) w (Netter et al., 1998) z (Wu et al., 1989, Jones and Gelbart, 1990, Jones and Gelbart, 1993, Peterson et al., 1994) E(z)61 nos (Pelegri and Lehmann, 1994) Sir2 (Furuyama et al., 2004) z (Wu et al., 1989, Jones and Gelbart, 1990) E(z)62 corto (Lopez et al., 2001) E(z)+t8.8 esc (Campbell et al., 1995) Pc (Campbell et al., 1995) E(z)son1 nos (Pelegri and Lehmann, 1994) E(z)son2 nos (Pelegri and Lehmann, 1994) E(z)son3 nos (Pelegri and Lehmann, 1994) E(z)Trm ash1 (Bajusz et al., 2001) Asx (Bajusz et al., 2001) aur (Bajusz et al., 2001) brm (Bajusz et al., 2001) E(Pc) (Bajusz et al., 2001) esc (Bajusz et al., 2001) kto (Bajusz et al., 2001) Mi-2 (Bajusz et al., 2001) osa (Bajusz et al., 2001) Pc (Bajusz et al., 2001) Pcl (Bajusz et al., 2001) pho (Bajusz et al., 2001) ph-p (Bajusz et al., 2001) Pp1-87B (Bajusz et al., 2001) Psc (Bajusz et al., 2001) Sce (Bajusz et al., 2001) Scm (Bajusz et al., 2001) skd (Bajusz et al., 2001) sls (Bajusz et al., 2001) Snr1 (Bajusz et al., 2001) Su(var)2-1 (Bajusz et al., 2001) sxc (Bajusz et al., 2001) Trl (Bajusz et al., 2001) urd (Bajusz et al., 2001) vtd (Bajusz et al., 2001) z (Bajusz et al., 2001) unspecified ara (Netter et al., 1998) ash2 (Bajusz et al., 2001) Pcl (Campbell et al., 1995) Sce (Campbell et al., 1995) Scm (Campbell et al., 1995) Scr (Gindhart and Kaufman, 1995) trx (Bajusz et al., 2001) z
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64582 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000629 DroID - A comprehensive database of gene and protein interactions. • FBgn0000629 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39203
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23825 Dere\GG13968 Dgri\GH16544 Dmoj\GI13833 Dper\GL15590 Dpse\GA19644 Dsec\GM24804 Dsim\GD12857 Dvir\GJ11699 Dwil\GK12358 Dyak\GE20265
Curated drosophilid orthologs	Dpse\GA19644
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013213-PA Aedes aegypti (mosquito) AGAP012516-PA Anopheles gambiae (mosquito) XP_624614.2 Apis mellifera (honey bee) XP_001947303.1 Acyrthosiphon pisum (pea aphid) At2g23380.1 Arabidopsis thaliana (wall cress) 250067 Branchiostoma floridae (lancelet) XP_001902470.1 Brugia malayi (roundworm nematode) BGIBMGA014476-PA Bombyx mori (silk worm) ENSBTAP00000012405 Bos taurus (bovine) CN16103 Caenorhabditis brenneri (small nematode) CBP33838 Caenorhabditis briggsae (nematode) CE28067 Caenorhabditis elegans (worm) ENSCAFP00000005090 Canis familiaris (dog) ENSCINP00000016340 Ciona intestinalis (sea squirt) CMQ156C Cyanidioschyzon merolae (red alga) cn11239 Cryptococcus neoformans (yeast-like fungus) CPIJ006484 Culex pipens (mosquito) ENSCPOP00000003350 Cavia porcellus (guinea pig) RP34400 Caenorhabditis remanei (nematode) ENSCSAVP00000003370 Ciona savignyi (sedentary tunicate) 20226 Capitella spl (polychaete worm) 300071 Daphnia pulex (daphnia) ENSDARP00000023693 Danio rerio (zebra fish) ENSECAP00000019360 Equus caballus (horse) ENSGACP00000007295 Gymnopilus aculeatus (mushroom) ENSGACP00000016542 Gymnopilus aculeatus (mushroom) ENSGALP00000020236 Gallus gallus (chicken) 99557 Hypsipyla robusta (cedar shoot borer) ENSP00000320147 Homo sapiens (human) ISCW020151-PA Ixodes scapularis (deer tick) 200654 Lottia gigantea (owl limpet) ENSMODP00000002264 Monodelphis domestica (gray opossum) ENSMMUP00000017740 Macaca mulatta (rhesus monkey) ENSMUSP00000080419 Mus musculus (house mouse) 195312 Nematostella vectensis (starlet anemone) XP_001599059.1 Nasonia vitripennis (wasp) ENSOANP00000000475 Ornithorynchus anatinus (platypus) ENSORLP00000003830 Oryzias latipes (japanese killifish) LOC_Os08g45130.1 Oryza sativa (asian rice) PHUM000843-PA Pediculus humanus (human body louse) ENSPPYP00000020354 Pongo pygmaeus (orangutan) 73447 Phytophthora ramorum (sudden oak death pathogen) 129422 Phytophthora sojae (root rot pathogen) 409555 Populus trichocarpa (black cottonwood) 818400 Populus trichocarpa (black cottonwood) ENSPTRP00000033970 Pan troglodytes (chimpanzee) ENSRNOP00000008149 Rattus norvegicus (norway rat) 4834595 Sorghum bicolor (sorghum) Smp_078900 Schistosoma mansoni (trematode parasite) XP_001195253.1 Strongylocentrotus purpuratus (purple sea urchin) 54464 Trichoplax adhaerens (metazoa) XP_001811652.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014645 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011299 Takifugu rubripes (pufferfish Takifugu) 3691.m00104 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000043568 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17647 NV18919 LH16500 ISCW020151 FBgn0237584 FBgn0214368 FBgn0198953 FBgn0184582 FBgn0179666 JGI_V11_300071 FBgn0079640 FBgn0153194 FBgn0136587 FBgn0124015 FBgn0106230 FBgn0100819 CPIJ006484 BGIBMGA014476 ACYPI009110 GB15558 AGAP012516 AAEL013213 AAEL012995 PHUM294210 GLEAN_03094
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	27993 y1 v1; P{TRiP.JF02826}attP2 31617 y1 v1; P{TRiP.JF01402}attP2 27149 y1 w*; P{EP}E(z)G4251 22471 y1 w67c23; P{EPgy2}E(z)EY21318 33659 y1 sc* v1; P{TRiP.HMS00066}attP2 36068 y1 sc* v1; P{TRiP.GL00486}attP40 24470 w*; E(z)731 P{1xFRT.G}2A/TM6C, Sb1 Tb1
VDRC	v107072 P{KK102729}VIE-260B v27645 w1118 P{GD11942}v27645 v27646 w1118; P{GD11942}v27646/TM3
Genomic Clones ( 1 )
	BACR10M10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD30505
Other clones	DPiM_LD30505
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03143 AT27956 GM23282 LD14652 RE16131 RE30421 RE39265 RE54527
Other clones	74628 108197 149691 Dmel_dig_014282_0693_0325 EK048205 EK234719 EK255413 FGC014D03 RP004076361 RP004122691 RP004144705 RP004177225 RP004191172 RP004212753 RP004216263 RP004216318 RP004236780 RP004246052 RP004260208 RP004261376 RP004263519 RP004425914 RP004451537 RP004467178 RP004531236 RP004536534
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000629 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39203
Antibody Information
	polyclonal (Carrington and Jones, 1996, Gambetta et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: E(z) CG6502 (Zhang, 1999.11)
Source for database merge of	Source for merge of: l(3)ds12 l(3)SG17 (Shearn, 1995.5.3)
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for E(z) protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) E(z) is required for normal neuroblast proliferation in postembryonic central nervous system development. (Bello et al., 2007) dsRNA has been made from templates generated with primers directed against this gene. RNAi of E(z) causes an increase in branch number and an expansion of the receptive field of class I neurons. RNAi also causes defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) E(z) is a Polycomb group protein. (Muller et al., 2002) esc protein, together with that of E(z), is present in a 600kD complex that is distinct from complexes containing other PcG proteins. The complex also includes the Rpd3 and Caf1 proteins. (Tie et al., 2001) Evidence of physical interaction between esc and E(z) in vitro and in vivo and coimmunoprecipitation in vivo suggests the proteins are direct partners in Pc-G mediated repression and this relationship has been evolutionarily conserved. (Jones et al., 1998) The gene products of esc and E(z) bind directly to each other and co-localize at multiple chromosomal sites. (Tie et al., 1998) E(z) protein is ubiquitously distributed in embryonic and larval nuclei and binds many of the same polytene chromosome nuclei as other Pc-G proteins. Lack of E(z) protein activity disrupts chromosome binding by trx protein. (Carrington and Jones, 1996) Although E(z) has been classified as a member of the Polycomb group of genes, it can also be classified as a member of the trithorax group. The requirement for E(z) activity as either a trithorax group or Polycomb group gene depends on the homeotic selector gene locus as well as on spatial and temporal cues. (LaJeunesse and Shearn, 1996) In an effort to subdivide the Pc-group genes functionally, the phenotypes of adult flies heterozygous for every pairwise combination of Pc-group mutation were examined. Genetic interactions have been demonstrated between esc, Asx, E(Pc), Pcl, E(z) and sxc. Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model. Duplications of E(z) enhance homeotic phenotypes of esc mutants. (Campbell et al., 1995) Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes. (Gindhart and Kaufman, 1995) E(z) activity is required for expression in the imaginal discs of Antp, Ubx, Scr and en. E(z) mutations exhibit interallelic non-complementation with ash1 mutations. (LaJeunesse and Shearn, 1995) E(z) mutations can express phenotypes characteristic of mutations in the trx-group of genes. Loss of function for E(z) during early development results in homeotic gene expression defects reminiscent of a trx-group mutation, while loss later in development results in gene expression defects characteristic of a Pc-group mutation. (LaJeunesse and Shearn, 1995) The effect of mutations in the E(z) locus on mutagenesis in the y2ns scme double superunstable system has been analysed. (Elagin et al., 1994) The intensity of trx binding to larval salivary gland polytene chromosomes is strongly decreased in larvae carrying mutations in E(z). (Kuzin et al., 1994) A screen for suppressors of nos mutations identified alleles of E(z). E(z) is a negative transcriptional regulator of kni and gt and is required to maintain their expression domain initiated by the maternal hb gradient. A small region of the kni promoter mediates regulation by E(z) and hb. Imprinting at the chromatin level may underlie the determination of anteroposterior polarity in the early embryo. (Pelegri and Lehmann, 1994) Molecular analysis of the E(z) gene. (Jones and Gelbart, 1993) The association of the Psc and Su(z)2 proteins with the chromosomes is dependent on the presence of active E(z) protein. (Rastelli et al., 1993) The bithorax complex genes are regulated by the Pc group of genes, acting via 'Pc group response elements' (PREs), that can work even when removed from the normal bithorax complex context. The Pc group products apparently provide stable memory or imprinting of boundaries which are specified by gap and pair-rule regulators. (Simon et al., 1993) Embryos mutant for two or more Pc group genes (Pc, Scm, Pcl, Psc, Asx, E(Pc), E(z), ph-d, pho and esc) show strong ectopic en expression, but only weak derepression occurs if embryo is mutant at only one of the Pc group genes. This effect is independent of the function of en itself, and wg. (Moazed and O'Farrell, 1992) Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Scm, Pcl, Sce, Asx, Psc, pho and Antp) cause abnormal segmental development due to the ectopic expression of abd-A and Abd-B. Embryos lacking both maternal and zygotic E(z) product were generated to determine abd-A and Abd-B expression patterns. (Simon et al., 1992) Reduction of E(z)+ activity suppresses the z1 eye colour. Maternally and zygotically produced E(z)+ activity is required to correctly regulate the segment identity genes during embryonic and imaginal development. (Jones and Gelbart, 1990) E(z) locus is involved in the suppression of the z1 eye colour and is also associated with homeotic transformations. (Wu et al., 1989) Locus named after original gain-of-function allele E(z)1 (Kalisch and Rasmuson, 1974); subsequently designated polycombeotic (pco) (by Phillips and Shearn, 1980) based on phenotype of lethal homozygotes. Loss of function alleles recovered as (a) recessive lethal mutations (b) reversions of E(z)1 and (c) reversions of the antimorphic allele, E(z)59. Reduction of E(z)+ activity leads to suppression of the z eye color, whereas gain-of-function alleles are dominant enhancers of zeste eye color <up>i.e., z w+/Y; E(z)1/+ males have brownish eyes as do z w+/z+ w+; E(z)1/+ females</up>. E(z)59 an antimorphic allele, is a dominant suppressor of z <up>i.e. z w+; E(z)59/+ females have orange eyes</up>. Hemizygosity for E(z)+ produces a very mild suppression of the z eye color. No effects on eye color in z+ or za backgrounds and effects on eye color not specific to a particular w allele. Reduction of E(z)+ activity also allows ectopic expression of the segment identity genes of the Antennapedia and bithorax gene complexes, resulting in homeotic transformations. This latter effect defines E(z) as a Polycomb-group locus. E(z)61 displays temperature-sensitive suppression of z eye color and homeotic phenotypes. At 22oC, z wis/Y; Hemizygous E(z)61 males have orange eyes and no homeotic transformations. At 29oC, such males have wild-type red eyes and die as pharate adults with strong homeotic transformations of the mesothoracic and metathoracic legs toward the prothoracic state. Embryos produced by E(z)61 homozygous females at 29oC die with homeotic transformations of most segments toward the eighth abdominal segment. Even two copies of paternally contributed E(z)+ does not rescue viability of these embryos. Complete lack of zygotically produced E(z)+ results in early pupal lethality and small imaginal discs. Larval brain squashes from individuals homozygous for an amorphic allele reveal a very low mitotic index; metaphase chromosomes irregularly condensed and fragmented (Gatti and Baker, 1989).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079297 NM_001144460 RefSeq (Proteins) • NP_524021 NP_001137932 DDBJ / EMBL / GenBank • AA978408 AAC46462 AAF50149 AAK93209 ACL83287 AW943033 AY051785 U00180 Entrez Gene - A searchable database of RefSeq genes. • 39203 UniProtKB/Swiss-Prot • P42124
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SANT domain, DNA binding (IPR001005) SET domain (IPR001214)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64582 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000629 DroID - A comprehensive database of gene and protein interactions. • FBgn0000629 DRSC - Results from RNAi screens. • FBgn0000629 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000629 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6502-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000629 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39203 InParanoid A subset of ortholog calls from InParanoid. • AAEL013213-PA Aedes aegypti (mosquito) AGAP012516-PA Anopheles gambiae (mosquito) XP_624614.2 Apis mellifera (honey bee) XP_001947303.1 Acyrthosiphon pisum (pea aphid) At2g23380.1 Arabidopsis thaliana (wall cress) 250067 Branchiostoma floridae (lancelet) XP_001902470.1 Brugia malayi (roundworm nematode) BGIBMGA014476-PA Bombyx mori (silk worm) ENSBTAP00000012405 Bos taurus (bovine) CN16103 Caenorhabditis brenneri (small nematode) CBP33838 Caenorhabditis briggsae (nematode) CE28067 Caenorhabditis elegans (worm) ENSCAFP00000005090 Canis familiaris (dog) ENSCINP00000016340 Ciona intestinalis (sea squirt) CMQ156C Cyanidioschyzon merolae (red alga) cn11239 Cryptococcus neoformans (yeast-like fungus) CPIJ006484 Culex pipens (mosquito) ENSCPOP00000003350 Cavia porcellus (guinea pig) RP34400 Caenorhabditis remanei (nematode) ENSCSAVP00000003370 Ciona savignyi (sedentary tunicate) 20226 Capitella spl (polychaete worm) 300071 Daphnia pulex (daphnia) ENSDARP00000023693 Danio rerio (zebra fish) ENSECAP00000019360 Equus caballus (horse) ENSGACP00000007295 Gymnopilus aculeatus (mushroom) ENSGACP00000016542 Gymnopilus aculeatus (mushroom) ENSGALP00000020236 Gallus gallus (chicken) 99557 Hypsipyla robusta (cedar shoot borer) ENSP00000320147 Homo sapiens (human) ISCW020151-PA Ixodes scapularis (deer tick) 200654 Lottia gigantea (owl limpet) ENSMODP00000002264 Monodelphis domestica (gray opossum) ENSMMUP00000017740 Macaca mulatta (rhesus monkey) ENSMUSP00000080419 Mus musculus (house mouse) 195312 Nematostella vectensis (starlet anemone) XP_001599059.1 Nasonia vitripennis (wasp) ENSOANP00000000475 Ornithorynchus anatinus (platypus) ENSORLP00000003830 Oryzias latipes (japanese killifish) LOC_Os08g45130.1 Oryza sativa (asian rice) PHUM000843-PA Pediculus humanus (human body louse) ENSPPYP00000020354 Pongo pygmaeus (orangutan) 73447 Phytophthora ramorum (sudden oak death pathogen) 129422 Phytophthora sojae (root rot pathogen) 409555 Populus trichocarpa (black cottonwood) 818400 Populus trichocarpa (black cottonwood) ENSPTRP00000033970 Pan troglodytes (chimpanzee) ENSRNOP00000008149 Rattus norvegicus (norway rat) 4834595 Sorghum bicolor (sorghum) Smp_078900 Schistosoma mansoni (trematode parasite) XP_001195253.1 Strongylocentrotus purpuratus (purple sea urchin) 54464 Trichoplax adhaerens (metazoa) XP_001811652.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014645 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011299 Takifugu rubripes (pufferfish Takifugu) 3691.m00104 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000043568 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/enhzeste.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39203 modMine - Data generated by the modENCODE project. • FBgn0000629 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17647 NV18919 LH16500 ISCW020151 FBgn0237584 FBgn0214368 FBgn0198953 FBgn0184582 FBgn0179666 JGI_V11_300071 FBgn0079640 FBgn0153194 FBgn0136587 FBgn0124015 FBgn0106230 FBgn0100819 CPIJ006484 BGIBMGA014476 ACYPI009110 GB15558 AGAP012516 AAEL013213 AAEL012995 PHUM294210 GLEAN_03094
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	CG6502 (Klebes et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) E(z) (Breiling et al., 2004, Chen and Rasmuson-Lestander, 2009, Talbert and Henikoff, 2006, Brown et al., 2005, Maeda and Karch, 2006, Schuettengruber, 2006, Wang et al., 2006, Papp and Muller, 2006, Parrish et al., 2006, Klymenko et al., 2006, Siebold et al., 2010, Joanis and Lloyd, 2002, Mishra et al., 2007, Nowak et al., 2011, Kalmykova et al., 2005, Gan et al., 2010, Lam et al., 2005, Huang et al., 2002, Chen et al., 2008, Bello et al., 2007, Muller and Kassis, 2006, Chen et al., 2008, Ringrose and Paro, 2007, Wicker-Thomas and Jallon, 2000, Simmons et al., 2007, de Ayala Alonso et al., 2007, Ali and Bender, 2004, Ketel et al., 2005, Nekrasov et al., 2007, Savla et al., 2008, Fujioka et al., 2008, Andreyeva et al., 2005, Parrish et al., 2007, Fanti et al., 2008, Phalke et al., 2009, Khan et al., 2009, Joshi et al., 2008, Gambetta et al., 2009, Gambetta et al., 2009, Tie et al., 2009, Classen et al., 2009, Goodliffe et al., 2007, Saj et al., 2010, Herz et al., 2010, Lee et al., 2010, Wilkinson et al., 2010, Gan et al., 2010, Pruteanu-Malinici et al., 2011) E(Z) (de la Cruz et al., 2005, Chopra and Mishra, 2005, Orlando, 2003, Kurzhals and Harte, 2003, Tie, 2002, Chang et al., 2002, Furuyama et al., 2001, Hart et al., 2001, Rusch and Kaufman, 2000, Ng et al., 2000, Wang et al., 2000, Ng et al., 2000, Wang et al., 2006, Schwartz and Pirrotta, 2007, Grewal and Elgin, 2007, Tie et al., 2007, Grimaud et al., 2006, Furuyama et al., 2003, Kahn et al., 2006, Tie et al., 2005, Joshi et al., 2008, Braunschweig et al., 2009, Taylor-Harding et al., 2004, Wang et al., 2006, Tie et al., 2007, Srinivasan et al., 2008, Kurzhals et al., 2008, Salvaing et al., 2006, Bartkuhn et al., 2009, Schwartz et al., 2006, Ohno et al., 2008, Wang et al., 2010, Schwartz et al., 2010, Filion et al., 2010, Margueron et al., 2009, Vatolina et al., 2011, Vatolina et al., 2011) E(z)1 (Naumova et al., 2000, Paro, 1990) E[z] (van Lohuizen, 1999) EZ (Henikoff et al., 2009, Craig, 2005, Orlando and Jones, 2002, Mito et al., 2007, Deal et al., 2010, Weber et al., 2010) Ez (Zuckerkandl, 1999, Bhadra et al., 2007, Guertin and Lis, 2010) l(3)67Fa (Jones and Gelbart, 1990, ) l(3)1902 (Gatti and Baker, 1989, Ripoll et al., 1987, Shearn et al., 1978, ) l(3)B12   l(3)ds12   l(3)SG17   pco (Fauvarque et al., 1995, Moazed and O'Farrell, 1992, Paro, 1990, Phillips and Shearn, 1990, Pirrotta, 1990, ) pco/E(z)   Su(z)301 (Melnikova et al., 1996, Docquier et al., 1996, Pirrotta, 1990)
Name Synonym	Enhancer of zeste (Breiling et al., 2004, Maeda and Karch, 2006, Schuettengruber, 2006, O'Dor et al., 2006, Mishra et al., 2007, Kavi et al., 2006, Chen et al., 2008, Bello et al., 2007, Muller and Kassis, 2006, Eissenberg, 2006, Wicker-Thomas and Jallon, 2000, Ali and Bender, 2004, Bartkuhn et al., 2009, Joshi et al., 2008, Classen et al., 2009, Balasov, 2002) Enhancer-of-Zeste (Henikoff et al., 2009) Enhancer-of-zeste (Schneider et al., 2002) enhancer of zeste (Leatherman and Jongens, 2003, Fanti et al., 2008, Deal et al., 2010) Enhancer of Zeste (Bienz, 2006, Huang et al., 2002, Braunschweig et al., 2009, Lee et al., 2010, Gan et al., 2010) enhancer-of-zeste (Weber et al., 2010) polycombeotic (Netter et al., 1998, Phillips and Shearn, 1990, )
Secondary FlyBase IDs
	FBgn0004710
References ( 317 )
Generate a list of	All references relating to this gene ( 317 )
List References by type	Research paper  ( 160 ) Supplementary material  ( 4 ) Review  ( 76 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 57 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Letter  ( 1 )
Recent research papers ( 18 )
	Nowak et al., 2011, J. Biol. Chem. 286(26): 23388--23396 Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites. [FBrf0213994] Pruteanu-Malinici et al., 2011, PLoS Comput. Biol. 7(7): e1002098 Automatic Annotation of Spatial Expression Patterns via Sparse Bayesian Factor Models. [FBrf0214618] Riddle et al., 2011, Genome Res. 21(2): 147--163 Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin. [FBrf0213099] Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 [Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster]. [FBrf0214456] Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster. [FBrf0216692] Deal et al., 2010, Science 328(5982): 1161--1164 Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. [FBrf0210910] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Gan et al., 2010, Genome Biol. 11(4): R42 Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. [FBrf0211027] Guertin and Lis, 2010, PLoS Genet. 6(9): Chromatin Landscape Dictates HSF Binding to Target DNA Elements. [FBrf0211835] Herz et al., 2010, Mol. Cell. Biol. 30(10): 2485--2497 The H3K27me3 demethylase dUTX is a suppressor of notch- and Rb-dependent tumors in Drosophila. [FBrf0210661] Lee et al., 2010, Mol. Cell. Biol. 30(10): 2563--2577 Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. [FBrf0210656] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Schwartz et al., 2010, PLoS Genet. 6(1): e1000805 Alternative epigenetic chromatin states of polycomb target genes. [FBrf0209708] Siebold et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(1): 169--174 Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. [FBrf0209752] Wang et al., 2010, Mol. Cell. Biol. 30(11): 2584--2593 Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a drosophila Hox gene. [FBrf0210763] Weber et al., 2010, Nat. Struct. Mol. Biol. 17(12): 1500--1507 H2A.Z nucleosomes enriched over active genes are homotypic. [FBrf0212462] Wilkinson et al., 2010, J. Cell. Biochem. 109(3): 478--486 PcG recruitment by the YY1 REPO domain can be mediated by Yaf2. [FBrf0209787] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...