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General Information
Symbol
Dmel\Fas2
Species
D. melanogaster
Name
Fasciclin 2
Annotation Symbol
CG3665
Feature Type
FlyBase ID
FBgn0000635
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
FasII, Fasciclin II, Fas II, 1D4, FasciclinII
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:4,132,887..4,206,093 [-]
Recombination map
1-7
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
Summaries
Pathway (FlyBase)
Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Protein Function (UniProtKB)
Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.
(UniProt, P34082)
Summary (Interactive Fly)
transmembrane - NCAM homolog - Ig superfamily - controls number and stability of neuromuscular synapses - regulates brush border length and organization in Drosophila renal tubules
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\Fas2 or the JBrowse view of Dmel\Fas2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.48
Gene model reviewed during 5.55
Gene model reviewed during 6.01
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070665
3439
873
FBtr0070666
2894
773
FBtr0070667
4225
811
FBtr0336882
3352
844
FBtr0336884
4893
859
FBtr0343523
3475
885
FBtr0343524
3260
832
Additional Transcript Data and Comments
Reported size (kB)
3.070, 2.818 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070633
96.9
873
5.89
FBpp0070634
86.3
773
5.73
FBpp0070635
90.1
811
5.75
FBpp0307830
94.1
844
5.89
FBpp0307832
95.9
859
6.02
FBpp0310127
98.4
885
6.02
FBpp0310128
93.1
832
6.01
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
873, 811 (aa); 97, 90 (kD predicted)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fas2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (42 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Appl; FB:FBgn0000108
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
Biological Process (26 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
inferred from expression pattern
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
traceable author statement
non-traceable author statement
traceable author statement
Cellular Component (15 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
(assigned by BHF-UCL )
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
(assigned by UniProt )
colocalizes_with postsynaptic membrane
inferred from direct assay
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
(assigned by BHF-UCL )
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
traceable author statement
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Fas2 transcripts are expressed strongly at the morphogenetic furrow in third instar larval eye discs. Levels are decreased for a few rows posterior to the furrow and then increase again at the posterior end of the disc.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
immunohistochemistry
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
inferred from author statements
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Fas2-XP is excluded from the calyx of the larval mushroom body, but not from the lobes.
Fas2 is enriched in fascicles in the neuropile and motor axons outside the CNS, but very low or absent in somatodendritic areas and nerve roots.
Fas2 protein is strongly upregulated just posterior to the morphogenetic furrow in third instar eye discs. After this initial strong expression in the preclusters, Fas2 expression is low in distinct ommatidial cluster patterns in the cell membranes of most photoreceptors. Eventually, elevated levels of Fas2 protein are seen just in one of the photoreceptor cells, namely R7.
. At late L3, Fas2-expressing cells appear at the boundary of tarsal region 5 and the pretarsus.
Fas2 is used a marker for immature larval photorecetor cells of Bolwig organ.
In stage 12 embryos, Fas2 protein is detected in the primordium of the pars lateralis. In the larva, it labels the axons of the dorsomedial and anteriolateral neurosecretory cells which form the pars intercerebralis and pars lateralis, respectively.
Fas2 is a marker for neural cell membranes
Fas2 is present in the periactive zone of the presynapse, but does not precisely colocalize with Dap-160, endoA, or dynamin.
In the adult prothorax and neck, Fas2 immunoreactivity is observed in the type II boutons of motorneurons innervating ventral cervical muscle 27 and prothoracic sternal anterior rotator muscle 31, but is undetectable in terminals located along the cuticle of the coxal midline. Fas2 is not detected at type I boutons of adult prothoracic neuromuscular junctions, unlike the pattern observed in larval neuromuscular junctions. Fas2 immunoreactivity is also observed in the trunk and branches of the cervical nerve, and in the glial cells surrounding the cervical nerve.
Fas2 protein is expressed in the three longitudinal fascicles of the embryonic longitudinal connectives, and in peripheral motor neurons.
In the developing germarium, Fas2 protein is expressed in all follicle cells during early oogenesis. At stage 7, Fas2 protein becomes apically localized in follicle cells, then is lost in migrating border follicle cells, while being localized to the leading edge of polar follicle cells.
Fas2 is found in the more mature mature, non-core neurons of the pedunculus of the 3rd instar larvae.
Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1, d2, d6, v1-3; deuterocerebrum - d9, d11, v2, v8
Fas2 protein is strongly expressed in the mushroom body alpha and beta lobes, and weakly in the mushroom body gamma-lobe and spur.
At stage 12, two neurons in each hemisphere express Fas2 protein, aCC and pCC. At this stage, the pCC growth cone which pioneers the MP1 pathway expresses Fas2 protein. By stage 13, it is expressed in other cells along the MP1 pathway. By stage 14, the MP1 pathway is continuous from segment to segment and Fas2 protein is expressed along its length as well as in some axons of the intersegmental nerve root including aCC. By stage 16, Fas2 protein is expressed in other longitudinal axon pathways. Outside of the CNS, it is expressed in the periphery in several motoneuron growth cones in each hemisegment including the aCC growth cone. In the PNS, it is expressed in some sensory neurons in most segments. It is expressed in patches in the ectoderm that will give rise to the spiracles, in Malpighian tubules, in the part of the hindgut bordering the Malpighian tubules and in ectodermal patches in the head.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from direct assay
(assigned by BHF-UCL )
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
(assigned by UniProt )
colocalizes_with postsynaptic membrane
inferred from direct assay
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
(assigned by BHF-UCL )
Expression Deduced from Reporters
Reporter: P{A92}A31
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GAL4}Mz507
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}Fas2rG272
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{unk}Fas2GFP397
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Fas2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 52 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 33 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Fas2
Transgenic constructs containing regulatory region of Fas2
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior fascicle & synapse, with Scer\GAL4elav-C155
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
axon & eye photoreceptor cell, with Scer\GAL4GMR.PF
axon & lamina, with Scer\GAL4GMR.PF
eye photoreceptor cell & lamina, with Scer\GAL4GMR.PF
fascicle & mushroom body | somatic clone
synapse & abdominal 2 ventral longitudinal muscle 1, with Scer\GAL4elav-C155
synapse & abdominal 3 ventral longitudinal muscle 1, with Scer\GAL4elav-C155
synapse & abdominal 4 ventral longitudinal muscle 1, with Scer\GAL4elav-C155
synapse & abdominal 5 ventral longitudinal muscle 1, with Scer\GAL4elav-C155
synapse & abdominal 6 ventral longitudinal muscle 1, with Scer\GAL4elav-C155
synapse & abdominal 7 ventral longitudinal muscle 1, with Scer\GAL4elav-C155
synapse & aCC neuron
synapse & aCC neuron, with Scer\GAL4B19
synapse & aCC neuron, with Scer\GAL4eve.RRK
synapse & RP2 neuron
synapse & RP2 neuron, with Scer\GAL4B19
synapse & RP2 neuron, with Scer\GAL4eve.RRK
synapse & RP3 neuron, with Scer\GAL4B19, Scer\GAL4eve.RRK
thorax & macrochaeta | somatic clone
thorax & microchaeta | somatic clone
U neuron & growth cone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
10 of 15
No
Yes
 
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
 
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
 
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
10 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
10 of 13
Yes
Yes
8 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
 
Xenopus tropicalis (Western clawed frog) (4)
4 of 12
Yes
Yes
2 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (12)
12 of 15
Yes
Yes
10 of 15
No
Yes
9 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (8)
5 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902KL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501T4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04IE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01O1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02K3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (18)
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Negative Regulators of Epidermal Growth Factor Receptor Signaling Pathway -
    Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-7
    Cytogenetic map
    Sequence location
    X:4,132,887..4,206,093 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    4B1-4B3
    Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    4B1-4B2
    (determined by in situ hybridisation) 4A--B (determined by in situ hybridisation) 4B (determined by in situ hybridisation) 4B1--4 (determined by in situ hybridisation)
    4A-4B
    (determined by in situ hybridisation) 4B (determined by in situ hybridisation)
    4B-4B
    (determined by in situ hybridisation)
    4B1-4B4
    (determined by in situ hybridisation) 4B (determined by in situ hybridisation)
    4B1-4B2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (26)
    Genomic Clones (41)
    cDNA Clones (122)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    polyclonal
    monoclonal, polyclonal
    Commercially Available Antibodies
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Fas2 CG3665
    Source for database merge of
    Source for merge of: Fas2 l(1)G0081 l(1)G0048 l(1)G0032 l(1)G0336 l(1)G0293
    Additional comments
    FlyBase curator comment: Correspondence with author Guntur confirmed that 'FAS 11' = 'Fas2' (CG3665).
    Other Comments
    Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.
    Fas2 and Appl form a biochemical complex in vivo.
    The ability of Fas2 to promote new synapse formation requires an Appl-dependent transduction cascade.
    Fas2 has a role in stabilizing branches during dorsal medial muscle innervation.
    Fas2 is required in the neurosecretory cells innervating the corpus allatum for normal genitalia rotation in males.
    Fas2 is required for the normal development of the lobes and the underlying structure of the mushroom body.
    Fas2 has a role in the molecular operations encoding short-term odour memories and conferring alcohol sensitivity.
    The detachment of the Bolwig's organ precursors from the optic lobe during embryogenesis may involve interaction between beat-Ia and Fas2 proteins.
    Levels of Fas2 protein may vary locally during synaptic growth.
    Relative balance of Sema-2a and Fas2 controls synaptogenesis.
    Target-derived Fas2 product regulates the pattern of synapse formation.
    The C-terminal sequences of Fas2 and Sh are both necessary and sufficient for targeting to the subsynaptic muscle membrane at the larval neuromuscular junction, and this localization depends on the product of dlg1.
    CrebB-17A acts in parallel with Fas2 to cause an increase in synaptic strength. cAMP initiates these parallel changes to achieve long-term synaptic enhancement. Expression of the CrebB-17A repressor in the dnc mutant blocks functional but not structural plasticity. Expression of the CrebB-17A activator increases synaptic strength, but only in Fas2 mutants that increase bouton number, due to increased presynaptic transmitter release. Expression of CrebB-17A in a Fas2 mutant background genetically reconstitutes cAMP-dependent plasticity. Thus, cAMP initiates parallel changes in CrebB-17A and Fas2 to achieve long-term synaptic enhancement.
    After synapse formation, the homophilic cell adhesion molecule Fas2 is localised both pre- and postsynaptically where it controls synapse stabilization. In null mutants synapse formation is normal but boutons retract during larval development. Synapse elimination and resulting lethality are rescued by transgenes that drive Fas2 expression both pre- and postsynaptically, expression on either side alone is not sufficient. Fas2 can also control synaptic growth.
    Downstream regulation of synaptic Fas2 expression is both necessary and sufficient for the long-term synaptic sprouting induced by increase in neuronal activity or increase in cAMP levels. Fas2 down-regulation on its own is not sufficient to alter synaptic strength, down regulation is therefore a step in the pathway controlling a purely structural component in the events of synaptic plasticity. Events downstream of cAMP must in part control the concomitant changes in synaptic function during long-term synaptic plasticity.
    The expression pattern of proneural genes of the AS-C and neurogenic genes of the E(spl)-C are examined in the procephlon and a map of the cells is constructed.
    Fas2 is required for induction of proneural gene expression in certain locations of the eye-antennal imaginal disc.
    Fas2 is required for proper morphogenesis of the neuromuscular junction. The size of the synaptic zone can be changed by altering the levels of Fas2. Results suggest Fas2 may play an important role in mediating structural changes during the activity-dependent events of synaptic plasticity.
    Changes in the pattern and level of Fas2 expression can alter growth cone guidance. Four classes of abnormal phenotypes can be caused by ectopic expression of Fas2 : "bypass" phenotypes, where axons fail to defasciculate at the choice point where they would normally enter their muscle target region; "detour" phenotypes, where bypass growth cones enter their muscle target region at a different location, "stall" phenotypes, where axons that enter their muscle target region fail to defasciculate from one another to probe their muscle targets; and "misroute" phenotypes, in which growth cones are diverted onto abnormal pathways by contact with Fas2-positive cells.
    Loss of function Fas2 mutations lead to the complete or partial defasciculation of the vMP2, MP1 and FN3 pathways. This mutant phenotype can be rescued by overexpression of Fas2. This overexpression can alter fasciculation by abnormally fusing pathways together. The results define an in vivo function for Fas2 as a neuronal recognition molecule that controls one mechanism of growth cone guidance - selective axon fasciculation - and genetically separates this function from other aspects of outgrowth and directional guidance.
    The phenotypes of Fas1, Fas2, Fas3 and nac mutants were analysed in the developing wing: the axon tracts in the CNS for the most part remain unaltered, and none of the phenotypes are 100% penetrant, indicating a fine-tuning role for these molecules in both the PNS and CNS.
    Antibody to Fas2 used in a screen for mutations affecting neuromuscular connectivity.
    The Fas2 gene has been isolated, and mutants generated, to study Fas2 function. Fas2 functions as a neuronal recognition molecule for the MP1 axon pathway.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 165 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (51)
    Reported As
    Symbol Synonym
    EG:EG0007.3
    Fas2
    (Tran et al., 2018, Wang et al., 2018, Bernardo-Garcia et al., 2017, Kline et al., 2017, Rohde et al., 2017, Wilson and Bergstralh, 2017, Battistini and Tamagnone, 2016, Gene Disruption Project members, 2016-, Krieger et al., 2016, Malartre, 2016, Ng et al., 2016, Quan et al., 2016, Schwartz et al., 2016, Aradska et al., 2015, Bergstralh et al., 2015, Bouleau and Tricoire, 2015, Duff et al., 2015, Grotewiel and Bettinger, 2015, Petsakou et al., 2015, Ashwal-Fluss et al., 2014, Cantera et al., 2014, Depetris-Chauvin et al., 2014, DeSalvo et al., 2014, FlyBase Genome Annotators, 2014, Hsieh et al., 2014, Hughes et al., 2014, Lee et al., 2014, Lotz et al., 2014, Stratoulias et al., 2014, Wolfram et al., 2014, Aleksic et al., 2013, Buhl et al., 2013, Coutinho-Budd and Freeman, 2013, Diaper et al., 2013, Huang et al., 2013, Marinho et al., 2013, Masoner et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Ozkan et al., 2013, Sen et al., 2013, Sivachenko et al., 2013, Alves-Silva et al., 2012, Gomez et al., 2012, Haberman et al., 2012, Kucherenko et al., 2012, Manning et al., 2012, Mosca et al., 2012, Mosca et al., 2012, Nose, 2012, Oyallon et al., 2012, Plavicki et al., 2012, Syed et al., 2012, Tsai et al., 2012, Yang et al., 2012, Zappia et al., 2012, Zarin et al., 2012, Awasaki et al., 2011, Awasaki et al., 2011, Baas et al., 2011, Franco et al., 2011, Guan et al., 2011, Hwang and Rulifson, 2011, Pandey et al., 2011, Rees et al., 2011, Xin et al., 2011, Xu et al., 2011, Aerts et al., 2010, Biehs et al., 2010, Inaki et al., 2010, Levine et al., 2010, Quinones et al., 2010, Reis et al., 2010, Silicheva et al., 2010, Stacey et al., 2010, von Hilchen et al., 2010, Williamson et al., 2010, Bottenberg et al., 2009, Defaye et al., 2009, Hazelett et al., 2009, Mao and Freeman, 2009, Merino et al., 2009, Seugnet et al., 2009, Tan et al., 2009, Allen and Spradling, 2008, Bogdanik et al., 2008, Gilestro, 2008, Miller et al., 2008, Vömel and Wegener, 2008, von Hilchen et al., 2008, Zhao et al., 2008, Aerts et al., 2007, Buszczak et al., 2007, Firth and Baker, 2007, Garbe et al., 2007, Kohsaka et al., 2007, Maines et al., 2007, Minidorff et al., 2007, Sakurai et al., 2007, Santos et al., 2007, Szafranski and Goode, 2007, Wang et al., 2007, Alekseyenko et al., 2006, Boyle et al., 2006, Garces and Thor, 2006, Molnar et al., 2006, Parker et al., 2006, Santos et al., 2006, Serpe and O'Connor, 2006, Terry et al., 2006, Zhang et al., 2006, Flatt et al., 2005, Haddrill et al., 2005, Mehta et al., 2005, Mehta et al., 2005, Tonning et al., 2005)
    FasII
    (Goyal et al., 2019, Coelho et al., 2018, Hur et al., 2018, Rieche et al., 2018, Busto et al., 2017, Nahm et al., 2016, Spring et al., 2016, Bornstein et al., 2015, Doll and Broadie, 2015, Harris and Littleton, 2015, Bulat et al., 2014, Coyle, 2014, Ghosh et al., 2014, Issman-Zecharya and Schuldiner, 2014, Lacin et al., 2014, Lacin et al., 2014, Luhur et al., 2014, Selcho et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Xing et al., 2014, Buhl et al., 2013, Chang et al., 2013, Diaper et al., 2013, Enneking et al., 2013, Gillespie and Hodge, 2013, He and Noll, 2013, Karsai et al., 2013, Khuong et al., 2013, Lee et al., 2013, Lerner et al., 2013, Lin et al., 2013, Masoner et al., 2013, McIlroy et al., 2013, Rallis et al., 2013, Riemensperger et al., 2013, Shen et al., 2013, Timmerman et al., 2013, Vandewalle et al., 2013, Wong et al., 2013, Yu et al., 2013, Yu et al., 2013, Boulanger et al., 2012, Celotto et al., 2012, Cho et al., 2012, Dani et al., 2012, Jeong et al., 2012, Kallijärvi et al., 2012, Kapfhamer et al., 2012, Krüttner et al., 2012, Kucherenko et al., 2012, Moraru et al., 2012, Osterloh et al., 2012, Sadananda et al., 2012, Takaesu et al., 2012, Wang et al., 2012, Yaniv et al., 2012, Zappia et al., 2012, Ayyub, 2011, Belacortu et al., 2011, Biersmith et al., 2011, Ding et al., 2011, Freeman et al., 2011, Goguel et al., 2011, Gonçalves-Pimentel et al., 2011, Henthorn et al., 2011, Keene et al., 2011, King et al., 2011, Koon et al., 2011, Miller et al., 2011, O'Keefe et al., 2011, Pappu et al., 2011, Pilgram et al., 2011, Tian et al., 2011, Weng et al., 2011, Xin et al., 2011, Zheng et al., 2011, Zhu and Bhat, 2011, Banovic et al., 2010, Chu-Lagraff et al., 2010, Coleman et al., 2010, Dorsten et al., 2010, Evans and Bashaw, 2010, Evans and Bashaw, 2010, Gong et al., 2010, Hebbar and Fernandes, 2010, Higashi-Kovtun et al., 2010, Kim et al., 2010, Liu et al., 2010, Malartre et al., 2010, Morimoto et al., 2010, Pauls et al., 2010, Pauls et al., 2010, Rohrbough and Broadie, 2010, Spitzweck et al., 2010, Wright et al., 2010, Yamamoto-Hino et al., 2010, Al-Anzi and Wyman, 2009, Bhuin and Roy, 2009, Campbell et al., 2009, Cardona et al., 2009, Chanana et al., 2009, Clements et al., 2009, Darya et al., 2009, Edwards and Meinertzhagen, 2009, Fuentes-Medel et al., 2009, Giagtzoglou et al., 2009, Honjo and Furukubo-Tokunaga, 2009, Jansen et al., 2009, Kim et al., 2009, Kim et al., 2009, Kumar et al., 2009, Kurusu et al., 2009, Leal et al., 2009, Lee et al., 2009, Lim and Kraut, 2009, Lin et al., 2009, Lin et al., 2009, Mao and Davis, 2009, Massaro et al., 2009, Massarwa et al., 2009, Meyer and Moussian, 2009, Sun et al., 2009, Syu et al., 2009, Urbano et al., 2009, Yan et al., 2009, Zhang et al., 2009, Berni et al., 2008, Bury et al., 2008, Chen et al., 2008, Daniels et al., 2008, Denef et al., 2008, Fung et al., 2008, Hoopfer et al., 2008, Learte et al., 2008, Lee et al., 2008, Lin et al., 2008, Mendoza-Topaz et al., 2008, Miller et al., 2008, Ostrowski et al., 2008, Pauli et al., 2008, Pauli et al., 2008, Pielage et al., 2008, Sawaya et al., 2008, Schuldiner et al., 2008, Stork et al., 2008, Tien et al., 2008, Tran and Doe, 2008, Yang et al., 2008, Zhu et al., 2008, Akan et al., 2007, Baker et al., 2007, Banerjee et al., 2007, de Velasco et al., 2007, Dorsten et al., 2007, Garbe et al., 2007, Griffiths et al., 2007, Grueber et al., 2007, Hattori et al., 2007, Kazama et al., 2007, Koh et al., 2007, Lee and Lundell, 2007, Ohyama et al., 2007, Pack-Chung et al., 2007, Pereanu et al., 2007, Qurashi et al., 2007, Rickmyre et al., 2007, Rogulja-Ortmann et al., 2007, Sprecher et al., 2007, Tajiri et al., 2007, Wu et al., 2007, Zhang et al., 2007, Ashraf et al., 2006, Awasaki et al., 2006, Ayoob et al., 2006, Brankatschk and Dickson, 2006, Choksi et al., 2006, Dickman et al., 2006, Didelot, 2006, Godenschwege et al., 2006, Hebbar et al., 2006, Hiramoto and Hiromi, 2006, Iyengar et al., 2006, Johnson et al., 2006, Kang et al., 2006, Layden et al., 2006, Meyer and Aberle, 2006, Pielage et al., 2006, Sarkar et al., 2006, Schmid et al., 2006, Sprecher and Hirth, 2006, Staudt et al., 2006, Strigini et al., 2006, Sun et al., 2006, Younossi-Hartenstein et al., 2006, Zhu et al., 2006, Ashley et al., 2005, Bhat, 2005, Carhan et al., 2005, Carthew, 2005, de Velasco and Hartenstein, 2005, Hoehne et al., 2005, Ice et al., 2005, Kristiansen et al., 2005, Labrador, 2005, Labrador et al., 2005, Merianda et al., 2005, Murthy et al., 2005, Nicolas and Preat, 2005, Pascual et al., 2005, Pereanu et al., 2005, Pütz et al., 2005, Rasse et al., 2005, Sakurai et al., 2005, Sanchez-Soriano and Prokop, 2005, Wu et al., 2005, Wu et al., 2005, Adolfsen et al., 2004, Awasaki and Ito, 2004, Broihier et al., 2004, Carhan et al., 2004, Cheesman et al., 2004, De Velasco et al., 2004, Dunlop et al., 2004, Forni et al., 2004, Fradkin et al., 2004, Griffiths and Hidalgo, 2004, Ivanov et al., 2004, Jefferis et al., 2004, Johnson et al., 2004, Lee et al., 2004, Marie et al., 2004, Marrus et al., 2004, Michel et al., 2004, Pascual et al., 2004, Rivlin et al., 2004, Schenck et al., 2004, Sprecher et al., 2004, Steigemann et al., 2004, Stewart and McLean, 2004, Wei et al., 2004, Zhan et al., 2004, Bolatto et al., 2003, Chang et al., 2003, Chang et al., 2003, Clements et al., 2003, Davis et al., 2003, Fan et al., 2003, Goode and Szafranski, 2003, Hartenstein et al., 2003, Hebbar et al., 2003, Mathew et al., 2003, McCabe et al., 2003, Nassif et al., 2003, Orihara et al., 2003, Ragone et al., 2003, Rawson et al., 2003, Reuter et al., 2003, Ritzenthaler and Chiba, 2003, Rothenberg et al., 2003, Shandala et al., 2003, Song and Taylor, 2003, Watts et al., 2003, Wucherpfennig et al., 2003, Younossi-Hartenstein et al., 2003, Zlatic et al., 2003, Baines et al., 2002, Bossing and Brand, 2002, Dumstrei et al., 2002, Emerson and Van Vactor, 2002, Hakeda-Suzuki et al., 2002, Hebbar and Fernandes, 2002, Jefferis et al., 2002, Jin, 2002, Kim et al., 2002, Koh et al., 2002, Mathew et al., 2002, Mellerick and Modica, 2002, Ng et al., 2002, Odden et al., 2002, Pennetta et al., 2002, Song et al., 2002, Stewart et al., 2002, Wang et al., 2002, Abrell and Jackle, 2001, Awasaki and Ito, 2001, Badenhorst, 2001, Baines et al., 2001, Baines et al., 2001, Billuart et al., 2001, Bodily et al., 2001, Chang et al., 2001, Chen and Olson, 2001, Emerson and Van Vactor, 2001, Gibbs, 2001, Kammermeier et al., 2001, Loureiro et al., 2001, Paradis et al., 2001, Pascual and Preat, 2001, Philip et al., 2001, Pipes et al., 2001, Sink et al., 2001, Sone et al., 2001, Tear, 2001, Waddell and Quinn, 2001, Whitford and Ghosh, 2001, Winberg et al., 2001, Booth et al., 2000, Certel et al., 2000, Chen and Rebay, 2000, Fritz and VanBerkum, 2000, Galindo and Couso, 2000, Kojima et al., 2000, Nagao et al., 2000, Rajagopalan et al., 2000, Schuster et al., 2000, Sigrist et al., 2000, Simpson et al., 2000, Sone et al., 2000, Strigini and Cohen, 2000, Sun et al., 2000, Suzuki and Saigo, 2000, van Meyel et al., 2000, Vogel, 2000, Wan et al., 2000, Yagi et al., 2000, Yu et al., 2000, Zaffran et al., 2000, Battye et al., 1999, Daniel et al., 1999, Desai et al., 1999, Fremion et al., 1999, Gorczyca et al., 1999, Hiesinger et al., 1999, Holmes and Heilig, 1999, Hsueh and Sheng, 1999, Hughes and Salinas, 1999, Kidd et al., 1999, Koh et al., 1999, Lamprecht, 1999, Landgraf et al., 1999, Lee et al., 1999, Lee et al., 1999, Scully et al., 1999, Siegler and Jia, 1999, Sigrist et al., 1999, Van Etten, 1999, Wills et al., 1999, Yu and Kolodkin, 1999, Abel et al., 1998, Brosamle, 1998, Chu et al., 1998, Davis and Goodman, 1998, Dormand and Brand, 1998, Eisen, 1998, Giniger, 1998, Halaby and Mornon, 1998, Hartenstein et al., 1998, Heilig, 1998.10.3, Hoch and Jackle, 1998, Kidd et al., 1998, Kidd et al., 1998, Kopczynski et al., 1998, Landmesser, 1998, Lekven et al., 1998, Loureiro and Peifer, 1998, Nassif et al., 1998, Nassif et al., 1998, O'Brien et al., 1998, Prokop et al., 1998, Speicher et al., 1998, Tissot et al., 1998, Winberg et al., 1998, Davis et al., 1997, Davis et al., 1997, Dittrich et al., 1997, Forjanic et al., 1997, Goodman, 1997, Goodman et al., 1997, Hall and Bieber, 1997, Hartenstein, 1997, Landmesser, 1997, Nose et al., 1997, Pan and Rubin, 1997, Petersen et al., 1997, Raghavan and White, 1997, Schmucker et al., 1997, Sun et al., 1997, Thomas et al., 1997, Thor and Thomas, 1997, Umemiya et al., 1997, Younossi-Hartenstein et al., 1997, Zaffran et al., 1997, Zito et al., 1997, Fambrough and Goodman, 1996, Fambrough et al., 1996, Koushika et al., 1996, Parras et al., 1996, Prokop et al., 1996, Romani et al., 1996, Roush, 1996, Sawamoto et al., 1996, Schuster et al., 1996, Younossi-Hartenstein et al., 1996, Brand and Dormand, 1995, Davis et al., 1995, Kania and Bellen, 1995, Keynes and Cook, 1995, Schuster et al., 1995, Desai et al., 1994, Lin and Goodman, 1994, Lin et al., 1994, Nose et al., 1994, Bodmer, 1993, Kania et al., 1993, van Vactor et al., 1993)
    anon-EST:Liang-1.60
    fas-II
    fasciclin II
    Name Synonyms
    Fasciclin II
    (Wilson and Bergstralh, 2017, Zinn and Özkan, 2017, Cassar and Kretzschmar, 2016, Bergstralh et al., 2015, Bulat et al., 2014, Coyle, 2014, Diaper et al., 2013, Lee et al., 2013, Ozkan et al., 2013, Dani et al., 2012, Giachello et al., 2012, Kapfhamer et al., 2012, Moraru et al., 2012, Plavicki et al., 2012, Ayyub, 2011, Copf et al., 2011, Godena et al., 2011, King et al., 2011, Mast et al., 2011, Mochizuki et al., 2011, Moua et al., 2011, Rodrigues et al., 2011, Shimizu et al., 2011, Weng et al., 2011, Bates et al., 2010, Chu-Lagraff et al., 2010, Coleman et al., 2010, Dorsten et al., 2010, Higashi-Kovtun et al., 2010, Jiao et al., 2010, Knight et al., 2010, Lee and Wu, 2010, Mosca and Schwarz, 2010, Pauls et al., 2010, Pauls et al., 2010, Sánchez-Soriano et al., 2010, Wright et al., 2010, Adolph et al., 2009, Al-Anzi and Wyman, 2009, Clements et al., 2009, Edwards and Meinertzhagen, 2009, Higuchi et al., 2009, Ho et al., 2009, Jansen et al., 2009, Kim et al., 2009, Leal et al., 2009, Lee et al., 2009, Massaro et al., 2009, Nagaraj et al., 2009, Palgi et al., 2009, Wolfstetter et al., 2009, Zlatic et al., 2009, Albornoz et al., 2008, Boone and Doe, 2008, Chen et al., 2008, Denef et al., 2008, Dorsten and VanBerkum, 2008, Hsouna and VanBerkum, 2008, Jeon et al., 2008, Lee et al., 2008, Liévens et al., 2008, Miller et al., 2008, Petrovic and Hummel, 2008, Schwenkert et al., 2008, Stork et al., 2008, Ayyub and Rodrigues, 2007, Beuchle et al., 2007, Dorsten et al., 2007, Gates et al., 2007, Grueber et al., 2007, Huang et al., 2007, Hülsmeier et al., 2007, Kazama et al., 2007, Ohyama et al., 2007, Pack-Chung et al., 2007, Rickmyre et al., 2007, Sterling et al., 2007, Whited et al., 2007, Zhang et al., 2007, Meier et al., 2006, Meyer and Aberle, 2006, Pielage et al., 2006, Sprecher et al., 2006, Sun et al., 2006, Ashley et al., 2005, Olofsson and Page, 2005, Savare et al., 2005, Collins and DiAntonio, 2004, Page, 2004, Stewart and McLean, 2004, Szafranski et al., 2004, Bolatto et al., 2003, Giesen et al., 2003, Hoeffer et al., 2003, Hsouna et al., 2003, Huang et al., 2003, Rawson et al., 2003, Ritzenthaler and Chiba, 2003, Song and Taylor, 2003, Vogel et al., 2003, Brody et al., 2002, Broihier and Skeath, 2002, Crowner et al., 2002, Fradkin et al., 2002, Fritz and VanBerkum, 2002, Niimi et al., 2002, Overton et al., 2002, Page, 2002, Reiff et al., 2002, Saito et al., 2002, Sedaghat and Sonnenfeld, 2002, Uhler et al., 2002, de Jong et al., 2001, De Jong et al., 2001, Kim et al., 2001, Milan et al., 2001, Schimmelpfeng et al., 2001, Sharrow and Tiemeyer, 2001, Lanoue et al., 2000, Radovic et al., 2000, Ruiz-Gomez et al., 2000, Schmucker et al., 2000, Sepp et al., 2000, Taniguchi et al., 2000, Teleman and Cohen, 2000, Anonymous, 1999, Auld, 1999, Baines et al., 1999, Hausser, 1999, Koh et al., 1999, Narayanan et al., 1999, Schau et al., 1999, Scully et al., 1999, Anonymous, 1998, Connolly and Tully, 1998, Deitcher et al., 1998, Hirth et al., 1998, Sanchez Soriano and Russell, 1998, Yu et al., 1998, Iwai et al., 1997, Jack and Myette, 1997, Stemerdink and Jacobs, 1997, Guan et al., 1996, Hartenstein et al., 1996, Mitchell et al., 1996, Goodman, 1995, Littleton et al., 1995, Goodman and Doe, 1993)
    Fasciculin II
    Fasiclin II
    fasciclin-2
    Secondary FlyBase IDs
    • FBgn0026682
    • FBgn0027230
    • FBgn0028323
    • FBgn0040201
    • FBgn0040202
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (1,035)