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General Information
Symbol
Dmel\fj
Species
D. melanogaster
Name
four-jointed
Annotation Symbol
CG10917
Feature Type
FlyBase ID
FBgn0000658
Gene Model Status
Stock Availability
Gene Snapshot
four-jointed (fj) encodes a type II transmembrane kinase. Through phosphorylation of the atypical cadherins encoded by ft and ds, it regulates control of planar polarity in epithelia and also growth via the Hippo/Warts pathway. [Date last reviewed: 2019-03-07]
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:18,232,761..18,236,311 [+]
Recombination map

2-85

RefSeq locus
NT_033778 REGION:18232761..18236311
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the FJX1/FJ family. (P54360)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
Protein Function (UniProtKB)
Golgi serine/threonine protein kinase required for intermediate growth in the proximal-distal axis. Phosphorylates specific residues within extracellular cadherin domains of Fat (ft) and Dachsous (ds) as they transit through the Golgi (PubMed:18635802). Acts in ommatidial polarity determination as a secondary signal downstream of Notch, JAK/STAT and wingless. Also necessary for the initiation, up-regulation or maintenance of Notch ligand, Serrate (Ser) expression in legs, thereby participating in a feedback loop with N signaling. Sufficient for joint formation and growth in the leg (PubMed:10607560, PubMed:11566858, PubMed:14757640, PubMed:7555705, PubMed:8606003).
(UniProt, P54360)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
fj: four jointed
thumb
fj: four jointed
Edith M. Wallace, unpublished.
Similar to d. Tarsi four instead of five jointed. Legs short and stocky, owing to failure of joint formation between second and third tarsal segments (Tokunaga and Gerhart, 1976, Genetics 83: s76). Femur, tibia, and tarsae foreshortened [Tokunaga and Gerhart, 1976; Mikuta, 1979, Genetika (Moscow) 15: 624-32]. Probability of joint failure proportional to degree of shortening of second tarsal segment (Tokunaga and Gerhart, 1976). Joint failure phenotype can extend into fj/+ tissue adjacent to fj/fj clones (Tokunaga and Gerhart, 1976). Leg chaetae show irregularities in the relative orientation of sockets and bracts (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). Enhanced by ssa and ssaB [Villee, 1945, Genetics 30: 26-27; Mglinetz and Ivanov, 1976, Genetika (Moscow) 12: 87-94] and by pb [Kaurov, Ivanov, and Mglinetz, 1978, Genetika (Moscow) 14: 306-12]; also influenced by AntpNs (Mikuta and Mglinetz). fj eyD flies have but three tarsal joints (Postlethwait and Schneiderman, 1975, Ann. Rev. Genet. 7: 381-433). Development similar to that of dachs [Waddington, 1943, J. Genet. 45: 29-43 (fig.)]. Wings shorter and broader with crossveins conspicuously closer together; veins diverge at greater angle (Tokunaga, Michinomae, Sizemore, and Gerhart, 1978, Genetics 88: s98). Effect visible in pupal wing (Waddington, 1940, J. Genet. 41: 75-139). Eyes smaller, ellipsoid, coarse textured; head foreshortened. RK2.
Summary (Interactive Fly)

transmembrane protein kinase that targets Fat and its transmembrane ligand Dachsous - conveys positional information in the leg and eye - regulates control of planar polarity in epithelia and also growth via the Hippo/Warts pathway

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\fj or the JBrowse view of Dmel\fj for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0086754
3551
583
Additional Transcript Data and Comments
Reported size (kB)

3.5 (northern blot)

3.7 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085933
65.5
583
8.74
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

583 (aa); 66 (kD predicted)

Comments

Rabbit antibody raised against amino acids 485-583. Rat antibody raised against amino acids 111-433.

External Data
Post Translational Modification

Proteolytically cleaved to yield a secreted protein.

(UniProt, P54360)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fj using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Wnt4; FB:FBgn0010453
Terms Based on Predictions or Assertions (0 terms)
Biological Process (12 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
inferred from expression pattern
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Wnt4; FB:FBgn0010453
inferred from mutant phenotype
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000322156
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000322156
(assigned by GO_Central )
inferred from sequence or structural similarity
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
dorsal ectoderm anlage

Comment: anlage in statu nascendi

mesoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

Additional Descriptive Data

fj transcripts are expressed at the highest level near the equator of the wing disc, are lower in intermediate regions, and are lowest near the dorsal and ventral poles. In the larval brain, they are expressed in laminar neuronal precursor cells and are again present in a gradient. In the wing disc, fj transcripts are expressed in a large central region including the wing pouch and in the leg disc, they are found in two concentric circles.

The fj transcript expression pattern closely resembles the enhancer trap staining pattern. Transcripts are expressed in concentric circles in leg discs from third instar larvae. At 4-6hrs after puparium formation, the disc has everted and the future tarsal segment boundaries are visible. A line of positive cells is seen adjacent to each tarsal furrow, with additional strong staining in the first tarsal segment and in the tibia. Weak expression in semicircular arcs is seen in the third instar antennal disc. Expression in the wing disc is concentrated in the prospective wing blade region. In eye discs, the strongest expression is observed in the central portion of the disc just anterior to the morphogenetic furrow, with no expression in the lateral portions of the disc. A gradient of expression is seen declining toward the posterior tip of the disc. In the larval brain, expression is concentrated in the outer optic anlage

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

fj protein is observed to be localized in a gradient ahead of the morphogenetic furrow in the eye disc, with highest expression near the dorsal-ventral midline. fj protein expression in the leg disc is observed in weak concentric rings, possibly corresponding to segment boundaries. Expression is weak in the pupal leg disc, with a stripe at the presumptive tarsal segment 1. Wing disc expression of fj protein is observed in the wing pouch in larval and pupal discs.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{GawB}fjVG1
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}fjp1
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}fjp2
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}fjp3
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}fjp4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}fjp5
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}fjp6
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}P55Cg4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}P55Ci10
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}P55Ci20
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fj in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fj
Transgenic constructs containing regulatory region of fj
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
abdominal segment 2 & macrochaeta
abdominal segment 2 & microchaeta
trichome & tergite | cell non-autonomous | somatic clone
trichome & tergite | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PL
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
 
Rattus norvegicus (Norway rat) (1)
12 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
6 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
5 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907HU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502NI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0676 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X062M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0L1D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map

    2-85

    Cytogenetic map
    Sequence location
    2R:18,232,761..18,236,311 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    55C1-55C1
    Limits computationally determined from genome sequence between P{PZ}Hsf03091&P{EP}Dgp-1EP731 and P{PZ}sbb04525&P{EP}EP1081EP1081
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    55B-55C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location

    2-81.5

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (20)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (39)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    polyclonal antibody

    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    Mutation of the DNE motif in fj abolishes its biological activity.

    fj regulates ft signaling by phosphorylating cadherin domains of ft and ds as they transit through the golgi.

    Gradients of fj and ds expression appear to provide partially redundant positional information essential for specifying the polarisation axis in the eye. The fidelity of planar cell polarity in the eye appears to result from the combined action of the fj and ds gradients acting through ft.

    In the wing, as well as in the eye, fj, ds and ft orient the direction of the fz-mediated intercellular feedback loop.

    fj play an important role in the regulation planar polarity in the compound eye.

    fj can direct ectopic growth and joint initiation in the leg when its normal pattern of expression is disturbed.

    fj has roles in anterior posterior growth of the abdominal segments and patterning of the wing veins.

    fj appears to act in ommatidial polarity as a second signal downstream of wg,hop and wg.

    The fj gene was identified in a screen for genes expressed in a non-uniform pattern along the dorsal-ventral axis of the eye. fj is required for proper leg, wing and eye development. Analysis of mutant phenotypes and expression patterns suggests that fj is required for cell-cell signalling during disc development.

    fj plays a role in a polar coordinate system of positional values in leg tissue.

    Analysis of the fj phenotype, expression pattern, molecular identity and biochemistry strongly supports previous work that suggests fj functions as a regional signalling molecule regulating growth and differentiation in specific portions of the leg and wing proximal distal axis. An in vitro transcription-translation-coupled translocation assay indicates that fj encodes a type II membrane glycoprotein and that in this in vitro system fj is synthesised in both a membrane bound and a secreted form.

    Origin and Etymology
    Discoverer

    Schultz, 1st April 1931.

    Etymology
    Identification
    External Crossreferences and Linkouts ( 38 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (9)
    Reported As
    Symbol Synonym
    fj
    (Gou et al., 2018, Mangione and Martín-Blanco, 2018, Montes and Morata, 2017, Gomez et al., 2016, Sarov et al., 2016, Willsey et al., 2016, Doggett et al., 2015, Enomoto et al., 2015, Hale et al., 2015, Kwon et al., 2015, Okumura et al., 2015, Parker and Struhl, 2015, Spratford and Kumar, 2015, Wang and Baker, 2015, Bossuyt et al., 2014, Mouri et al., 2014, Qing et al., 2014, Sing et al., 2014, Sopko et al., 2014, Djiane et al., 2013, Hazelwood and Hancock, 2013, Irvine, 2013.3.28, Kwon et al., 2013, Perea et al., 2013, Sharma and McNeill, 2013, Webber et al., 2013, Zhao et al., 2013, Ambegaonkar et al., 2012, Ambegaonkar et al., 2012, Bosveld et al., 2012, Bosveld et al., 2012, Brittle et al., 2012, Matakatsu and Blair, 2012, Bao et al., 2011, Boggiano et al., 2011, Genevet and Tapon, 2011, Goodrich and Strutt, 2011, Hogan et al., 2011, Richter et al., 2011, Slattery et al., 2011, Brittle et al., 2010, Frise et al., 2010, Grzeschik et al., 2010, Herz et al., 2010, Li et al., 2010, McNeill, 2010, Reddy et al., 2010, Shao et al., 2010, Zecca and Struhl, 2010, Aerts et al., 2009, Chung et al., 2009, Feng and Irvine, 2009, Sopko et al., 2009, Rogulja et al., 2008, Terriente et al., 2008, Willecke et al., 2008, Arbouzova and McNeill, 2007, Beltran et al., 2007, Buszczak et al., 2007, Christensen et al., 2007.10.29, Lawrence et al., 2007, Tyler et al., 2007, Casal et al., 2006, Cho et al., 2006, Willecke et al., 2006, Lim et al., 2005, Strutt and Strutt, 2005, Fanto and McNeill, 2004, Strutt et al., 2004, Tsai and Sun, 2004, Fanto et al., 2003)
    Secondary FlyBase IDs
      Datasets (1)
      Study focus (1)
      Experimental Role
      Project
      Project Type
      Title
      • bait_protein
      Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
      References (218)