fliA, l(1)2Cb, a-actinin, EG:133E12.1 , Alpha-actinin
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Shares 5' UTR with upstream gene.
Gene model reviewed during 5.46
Gene model reviewed during 5.56
3.4, 1.9 (northern blot)
895 (aa); 98 (kD)
partial CDS encoded by alternate exon
The EF hands of the Drosophila Actn protein are theoretically capable of binding Ca2+ and this portion of the protein is more similar to the nonmuscle isoform of chicken and the alpha-actinin of Dictyostelium than to the vertebrate sarcomeric and smooth muscle isoforms. Drosophila Actn protein is recognized by a monoclonal antibody made against Lethocerus alpha-actinin.
Homodimer; antiparallel. Interacts with Smn; the interaction occurs in adult thoracic tissues.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Actn using the Feature Mapper tool.
The 3.4kb Actn transcripts are found at all stages of development tested including early embryos and early pupae, times at which no muscles are present.
Actn protein is organized in a dynamic manner in follicle cells during oogenesis.
Actn protein can be detected in scattered aggregates dispersed in the cytoplasm of muscle cell precursors as early at 30 hrs APF. By 48 hours Actn, along with other myofibrillar proteins, have organized into Z-bands.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Actn in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
A protein of the Z-bands of all muscles.
The structure and function of Actn and related microfilament cross-linking proteins is investigated.
The structural gene for α Actinin.
Both lethal and viable alleles recovered. Lethal alleles die in late larval or early pupal stages; homozygous maternal germ-line clones produce normal ova. Viable alleles unconditionally flightless; wing position normal, but unable to fly or beat wings; jump abnormally short distances. Gynandromorph studies of Actn1 indicate a bilateral pair of submissive foci located mid ventrally close to the embryonic midline (FBrf0048188). ERG normal (FBrf0050364).