Fmrf, dFMRFa, dFMRFamide, DPKQDFMRFamide, FMRFamide-related
neuropeptide of unknown function in Drosophila expressed in sets of brain and ventral cord neurons - induces contractions in Drosophila body wall muscle fibers in a Ca2+ -dependent manner - Retrograde Gbb signaling through the Bmp type 2 receptor Wishful Thinking regulates systemic FMRFa expression
Gene model reviewed during 5.39
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Small FMRFa-derived neuropeptides identified by 2D capillary LC/ESI-MS/MS: DPKQDFMRF-amide, MDSNFIRF-amide, PDNFMRF-amide, SDNFMRF-amide, SVQDNFMHF-amide, TPAEDFMRF-amide.
Small FMRFa-derived neuropeptides identified by LC-MS/MS: DPKQDFMRF-amide, TPAEDFMRF-amide, SDNFMRF-amide, PDNFMRF-amide.
This precursor includes 13 peptides that have FMRF or related sequences at their C-termini, and other putative neuropeptides.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FMRFa using the Feature Mapper tool.
FMRFa protein is detected in fibers running dorsally and laterally on the fan-shaped body which seem to innervate layer 4. Co-localisation with Scer\GAL4Gad1.3.098 is observed in a pair of neurons in the posterior lateral protocerebrum and often, another pair at the base of the optic lobes.
Fmrf is expressed in the peptidergic Tv neurons in the larval thoracic ventral nerve cord.
Fmrf protein expression correlates with Fmrf transcript expression. Fmrf protein continues to be detected in prepupal through adult stages. Many larval neuronal signals continue to be detected in the adult. In addition, adult-specific signals are detected in the adult brain and ventral ganglion.
GBrowse - Visual display of RNA-Seq signalsView Dmel\FMRFa in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: FMRFa Fmrf
FlyBase curator comment: Renamed from 'Fmrf/FMRFamide-related' to 'FMRFa/FMRFamide' to reflect usage in the literature and introduce consistency in the nomenclature between this gene and 'FMRFaR'.
Genetic and molecular analysis of the 46C-46D region suggests that Fmrf is not an essential gene.
The Fmrf peptides may play a number of functional roles, perhaps affecting both physiological and developmental phenomena.
Isolated from a genomic library using an Aplysia cDNA encoding most of the FMRFamide coding region as a probe.
Fmrf encodes multiple copies of related neuropeptides within a single precursor protein.
Encodes the precursor polypeptide that is processed to generate a nonapeptide, DPKQDFMRFamide, that shares homology with the FMRFamide neuropeptide from molluscs. Gene appears to be expressed from late embryogenesis through the adult stage (see also White, Hurteau and Punsal, 1986).