dg2, PKG, l(2)06860, FOR/PKG
cGMP-dependent protein kinase - controls feeding behavior and locomotion - regulates motor axon guidance in Drosophila by suppressing Lola function - inhibition of For extends the upper temperature limit of stimulus-evoked calcium responses in motoneuronal boutons of Drosophila larvae behavior
Please see the JBrowse view of Dmel\for for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 6.12
Gene model reviewed during 6.01
Transposon inserted in intron
Annotated transcripts do not represent all supported alternative splices within 5' UTRs.
Gene model reviewed during 5.49
Gene model reviewed during 6.19
4.6, 4.4, 3.6 (northern blot)
1088, 934, 919, 894, 742, 567 (aa)
One of several protein products
Putative product of the "T3a" transcript.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\for using the Feature Mapper tool.
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalon primordium
Comment: reported as procephalon primordium
Comment: reported as procephalon primordium
Comment: reported as procephalon primordium
Comment: reported as procephalon primordium
Comment: reported as procephalon primordium
Comment: Expression specific to for-T2 transcripts (for-RC, -RD, -RF, -RG, -RK)
Comment: tightly localized;expression assayed in cultured cells
Comment: Antibody specific to for-T1 (for-PA, -PI, -PH) and for-T3 (for-PB) isoforms
for protein is detected in the adult optic lobe, mushroom body, a cluster of cells in the dorsal protocerebrum (DPC's) and in one cell in the lateral dorsal protocerebrum (LC). Expression of for protein is similar to that of Scer\GAL4for-11.247 and Scer\GAL4NP2614 except that the DPC's are only labelled by the for protein.
for protein is expressed in five cell clusters in the adult brain. One cluster contains an average of 27 neurons per hemisphere and is located dorsolaterally to the antennal lobes, and whose projections extend to the ellipsoid body. These cells could correspond to large- and small-field neurons that innervate the ellipsoid body. The second cluster is composed of 4 to 5 neurons with large cell bodies at the dorsoposterior tip of the central brain. The third cluster of neurons is located in the medial optic lobe. Most of these neurons have weak expression of for protein in the nucleus, and are scattered dorsoventrally; one neuron of this optic lobe cluster can be distinguished from the rest because of its more dorsal position, its large diameter and strong cytoplasmic and/or plasma membrane staining. A fourth cluster of neurons labeled by for protein is scattered in the anterior and frontal region of the brain, dorsal to the subesophageal ganglion and ventral to the antennal lobes. The fifth cluster of cells is not neuronal and is located in the outer medulla, in the lateral optic lobe. for protein also strongly labels three nerve fibres. One is the antennal nerve, its ventrolateral entry point to the antennal lobes and the antennal mechanosensory and motor center where it projects to. The other two are a pair of nerves that innervate the subesophageal ganglion. Diffuse expression of for protein is seen throughout the brain, most frequently in the mushroom bodies and in the ellipsoid body.
Comment: low expression in the adult brain cortex
GBrowse - Visual display of RNA-Seq signals
View Dmel\for in GBrowse 22-8.9
Maps adjacent to cutlet.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: for l(2)06860
Source for merge of: for CG10033
Source for merge of: for BcDNA:GM08338
Source for merge of: for anon-WO0140519.260 anon-WO02059370.47
Source for merge of for BcDNA:GM08338 was a shared cDNA ( date:020730 ).
Source for merge of for anon-WO0140519.260 anon-WO02059370.47 was sequence comparison ( date:051113 ).
Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, aneuploidy, an increase in mitotic index and a whole range of mitotic abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
"Rover" and "sitter" variants isolated from natural populations show distinct excitability patterns, with spontaneous activities and excessive evoked firing in sitter but not rover neurons. Sitter neurons show reduced voltage dependent K+ currents and excitable synapses. Axon terminal projections are altered in sitter strains.
for activity levels influence adult olfactory trap response to a food medium attractant.
Rover and sitter larvae derived from nature differ in the distance adults walk after feeding, and this variation maps to the for locus.
The major gene responsible for foraging strategy of feeding larvae.
Larvae from so-called "sitter" strains move about 6.5 cm in five minutes while feeding on a yeasted surface, whereas those from so-called "rover" strains travel some 17 cm; heterozygotes are rovers. Several X-ray induced reversions of the dominant "rover" phenotype shown to be non-complementing lethals which map to 10 on chromosome 2, thus localizing a major behavioral locus.
Isolated from a genomic library using a Pka-C1 probe.