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General Information
Symbol
Dmel\for
Species
D. melanogaster
Name
foraging
Annotation Symbol
CG10033
Feature Type
FlyBase ID
FBgn0000721
Gene Model Status
Stock Availability
Enzyme Name (EC)
cGMP-dependent protein kinase (2.7.11.12)
Gene Snapshot
foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function. [Date last reviewed: 2019-03-07]
Also Known As
dg2, PKG, l(2)06860, FOR/PKG
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:3,622,074..3,656,953 [-]
Recombination map
2-10
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. (P32023Q03043)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
Catalytic Activity (EC)
Experimental Evidence
ATP + a protein = ADP + a phosphoprotein (2.7.11.12)
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
PROTEIN KINASE G FAMILY -
The Protein Kinase G (PKG) family are serine/threonine kinases activated by cGMP. PKG forms homodimers and are regulated by auto-inhibition through a pseudosubstrate motif. (Adapted from PMID:20027184).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
for: foraging
The major gene responsible for foraging strategy of feeding larvae. Larvae from so-called sitter strains move about 6.5 cm in five minutes while feeding on a yeasted surface, whereas those from so-called rover strains travel some 17 cm; heterozygotes are rovers. Several X-ray induced reversions of the dominant rover phenotype shown to be non-complementing lethals which map to 10 on chromosome 2, thus localizing a major behavioral locus.
Pkg2
Encodes products with putative cGMP-dependent protein kinase activities (indicated by sequencing data obtained for all but two of the predicted proteins). The role of the gene and its enzymes in the organism as a whole is unknown at present.
Summary (Interactive Fly)
cGMP-dependent protein kinase - controls feeding behavior and locomotion - regulates motor axon guidance in Drosophila by suppressing Lola function - inhibition of For extends the upper temperature limit of stimulus-evoked calcium responses in motoneuronal boutons of Drosophila larvae behavior
Gene Model and Products
Number of Transcripts
13
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\for or the JBrowse view of Dmel\for for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 6.12
Gene model reviewed during 6.01
Transposon inserted in intron
Annotated transcripts do not represent all supported alternative splices within 5' UTRs.
Gene model reviewed during 5.49
Gene model reviewed during 6.19
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089304
4595
1088
FBtr0089307
3778
894
FBtr0089308
4218
894
FBtr0089306
4338
934
FBtr0089309
3826
894
FBtr0089310
4316
1088
FBtr0089312
4581
1088
FBtr0100363
3886
934
FBtr0301399
3223
894
FBtr0446099
3436
742
FBtr0473363
3016
568
FBtr0473364
2737
568
FBtr0473365
2467
471
Additional Transcript Data and Comments
Reported size (kB)
4.6, 4.4, 3.6 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088350
121.3
1088
6.15
FBpp0088353
101.1
894
8.32
FBpp0088354
101.1
894
8.32
FBpp0088352
105.9
934
8.32
FBpp0088924
101.1
894
8.32
FBpp0088922
121.3
1088
6.15
FBpp0088923
121.3
1088
6.15
FBpp0099769
105.9
934
8.32
FBpp0290613
101.1
894
8.32
FBpp0402801
83.3
742
5.84
FBpp0422967
65.1
568
5.51
FBpp0422968
65.1
568
5.51
FBpp0422969
54.1
471
5.61
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

934 aa isoforms: for-PE, for-PJ
894 aa isoforms: for-PC, for-PD, for-PG, for-PK
1088 aa isoforms: for-PA, for-PH, for-PI
568 aa isoforms: for-PM, for-PN
Additional Polypeptide Data and Comments
Reported size (kDa)
1088, 934, 919, 894, 742, 567 (aa)
Comments
One of several protein products.
One of several protein products
Putative product of the "T3a" transcript.
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\for using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (16 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
traceable author statement
traceable author statement
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: Expression specific to for-T2 transcripts (for-RC, -RD, -RF, -RG, -RK)

RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
enzyme assay or biochemical detection
Stage
Tissue/Position (including subcellular localization)
Reference
epitope tag
Stage
Tissue/Position (including subcellular localization)
Reference

Comment: tightly localized;expression assayed in cultured cells

immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult head

Comment: Antibody specific to for-T1 (for-PA, -PI, -PH) and for-T3 (for-PB) isoforms

Additional Descriptive Data
for protein is detected in the adult optic lobe, mushroom body, a cluster of cells in the dorsal protocerebrum (DPC's) and in one cell in the lateral dorsal protocerebrum (LC). Expression of for protein is similar to that of Scer\GAL4for-11.247 and Scer\GAL4NP2614 except that the DPC's are only labelled by the for protein.
for protein is expressed in five cell clusters in the adult brain. One cluster contains an average of 27 neurons per hemisphere and is located dorsolaterally to the antennal lobes, and whose projections extend to the ellipsoid body. These cells could correspond to large- and small-field neurons that innervate the ellipsoid body. The second cluster is composed of 4 to 5 neurons with large cell bodies at the dorsoposterior tip of the central brain. The third cluster of neurons is located in the medial optic lobe. Most of these neurons have weak expression of for protein in the nucleus, and are scattered dorsoventrally; one neuron of this optic lobe cluster can be distinguished from the rest because of its more dorsal position, its large diameter and strong cytoplasmic and/or plasma membrane staining. A fourth cluster of neurons labeled by for protein is scattered in the anterior and frontal region of the brain, dorsal to the subesophageal ganglion and ventral to the antennal lobes. The fifth cluster of cells is not neuronal and is located in the outer medulla, in the lateral optic lobe. for protein also strongly labels three nerve fibres. One is the antennal nerve, its ventrolateral entry point to the antennal lobes and the antennal mechanosensory and motor center where it projects to. The other two are a pair of nerves that innervate the subesophageal ganglion. Diffuse expression of for protein is seen throughout the brain, most frequently in the mushroom bodies and in the ellipsoid body.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{GawB}for11.247
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}forNP0285
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}forNP2614
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}lilli189Y
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain cell body rind

Comment: low expression in the adult brain cortex

Reporter: TI{TI}forV5
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\for in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 84 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of for
Transgenic constructs containing regulatory region of for
Deletions and Duplications ( 20 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
4 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
5 of 13
No
Yes
 
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
1 of 12
Yes
No
1 of 12
Yes
No
1 of 12
Yes
Yes
1 of 12
Yes
No
1 of 12
Yes
No
Danio rerio (Zebrafish) (11)
11 of 15
Yes
Yes
9 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
No
3 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
7 of 15
Yes
No
5 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
6 of 9
Yes
Yes
1 of 9
No
Yes
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
2 of 15
Yes
No
2 of 15
Yes
No
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190290 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915018Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03T0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03Q7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0S9R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
7 of 10
7 of 10
3 of 10
3 of 10
3 of 10
3 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-10
    Cytogenetic map
    Sequence location
    2L:3,622,074..3,656,953 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    24A2-24A4
    Limits computationally determined from genome sequence between P{PZ}oddrF111&P{PZ}for06860 and P{EP}EP2595EP2595
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    24A1-24A2
    (determined by in situ hybridisation)
    24A1-24A2
    24A3--3 24A3--4
    24A-24A
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Right of (cM)
    Notes
    Maps adjacent to cutlet.
    Stocks and Reagents
    Stocks (54)
    Genomic Clones (19)
    cDNA Clones (261)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Source for merge of: for l(2)06860
      Source for merge of: for CG10033
      Source for merge of: for BcDNA:GM08338
      Source for merge of: for anon-WO0140519.260 anon-WO02059370.47
      Additional comments
      Source for merge of for BcDNA:GM08338 was a shared cDNA ( date:020730 ).
      Source for merge of for anon-WO0140519.260 anon-WO02059370.47 was sequence comparison ( date:051113 ).
      Other Comments
      Duplicate transcripts identified and eliminated during the migration of annotations from the release 5 genome assembly to the release 6 assembly.
      When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, aneuploidy, an increase in mitotic index and a whole range of mitotic abnormalities are seen.
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      "Rover" and "sitter" variants isolated from natural populations show distinct excitability patterns, with spontaneous activities and excessive evoked firing in sitter but not rover neurons. Sitter neurons show reduced voltage dependent K+ currents and excitable synapses. Axon terminal projections are altered in sitter strains.
      for activity levels influence adult olfactory trap response to a food medium attractant.
      Csr and nob interact with for.
      Rover and sitter larvae derived from nature differ in the distance adults walk after feeding, and this variation maps to the for locus.
      The observation that three of five cutlet alleles have a coincident altered larval foraging phenotype leads to speculate that for and cutlet may constitute a complex locus.
      The major gene responsible for foraging strategy of feeding larvae.
      Larvae from so-called "sitter" strains move about 6.5 cm in five minutes while feeding on a yeasted surface, whereas those from so-called "rover" strains travel some 17 cm; heterozygotes are rovers. Several X-ray induced reversions of the dominant "rover" phenotype shown to be non-complementing lethals which map to 10 on chromosome 2, thus localizing a major behavioral locus.
      Isolated from a genomic library using a Pka-C1 probe.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 153 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (17)
      Reported As
      Symbol Synonym
      BcDNA:GM08338
      Dg2
      Pkg2
      Pkg24A
      anon-WO0140519.260
      anon-WO02059370.47
      for
      (Dason et al., 2019, Kelly and Dawson-Scully, 2019, Kockel et al., 2019, Song et al., 2019, Allen et al., 2018, Gene Disruption Project members, 2018-, Hughson et al., 2018, Lee et al., 2018, Allen et al., 2017, Anreiter et al., 2017, Wang and Sokolowski, 2017, Carbone et al., 2016, Gene Disruption Project members, 2016-, Kang et al., 2016, Lefebvre et al., 2016, Levinson and Cagan, 2016, Myat and Patel, 2016, Peng et al., 2016, Philippe et al., 2016, Spong et al., 2016, Aradska et al., 2015, Dissel et al., 2015, Fernando et al., 2015, Gene Disruption Project members, 2015-, Morozova et al., 2015, Schleede and Blair, 2015, Shiao et al., 2015, Yurgel et al., 2015, Ashwal-Fluss et al., 2014, Camiletti et al., 2014, Chandran et al., 2014, DeSalvo et al., 2014, FlyBase Genome Annotators, 2014, Sopko et al., 2014, Caplan et al., 2013, de Celis et al., 2013.9.11, Foucaud et al., 2013, Kohn et al., 2013, Patel and Myat, 2013, Yin et al., 2013, Bendena et al., 2012, Donlea et al., 2012, Eddison et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Patel et al., 2012, Arthaud et al., 2011, Chen et al., 2011, Chow et al., 2011, Hou et al., 2011, Müller et al., 2011, Reaume et al., 2011, Simon et al., 2011, Toku et al., 2011, Dawson-Scully et al., 2010, Keene et al., 2010, Kong et al., 2010, Sokolowski, 2010, Gioia and Zars, 2009, Kent et al., 2009, Li et al., 2009, Kaun et al., 2008, Wang et al., 2008, Belay et al., 2007, Buszczak et al., 2007, Dawson-Scully et al., 2007, Fitzpatrick et al., 2007, Kaun et al., 2007, Kaun et al., 2007, Mery et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Stahl et al., 2007, Zhang et al., 2007, Brandt, 2006, Molnar et al., 2006, Reaume and Sokolowski, 2006, Riedl et al., 2005, MacPherson et al., 2004, Scheiner et al., 2004, Tinette et al., 2004, Hall, 2003, Osborne et al., 2001, Engel et al., 2000)
      Secondary FlyBase IDs
      • FBgn0000443
      • FBgn0010629
      • FBgn0031555
      • FBgn0044607
      • FBgn0063202
      • FBgn0066013
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (264)