Fps85D, dfps85D, DmHD-179, Fps oncogene analog, Dfer
Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions - regulates dorsal closure
Please see the JBrowse view of Dmel\FER for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 6.32
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FER using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
JBrowse - Visual display of RNA-Seq signals
View Dmel\FER in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
The 92kD and 45kD Fps85D protein isoforms can transform avian and rodent cells when expressed from retroviral vectors.
Phylogenetic analysis of the PTK family.
Isolated using an avian v-fps gene fragment as a probe.
Fps85D has been cloned, sequenced and its expression pattern analysed.
Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
Source for identity of: Fps85D CG8874
Source for identity of: FER Fps85D
Named "FER" after the human ortholog.