FlyBase Gene Report: Dmel\FER

General Information

Symbol

Dmel\FER

Species

D. melanogaster

Name

FER tyrosine kinase

Annotation Symbol

CG8874

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000723

Gene Model Status

Current

Stock Availability

18 publicly available

Enzyme Name (EC)

non-specific protein-tyrosine kinase (2.7.10.2)

Gene Summary

Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm. (UniProt, P18106)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Fps85D, dfps85D, DmHD-179, Fps oncogene analog, Dfer

Key Links

Genomic Location

Cytogenetic map

85D13-85D15

Sequence location

3R:9,367,603..9,394,546 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:9367603..9394546

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables non-membrane spanning protein tyrosine kinase activity

inferred from electronic annotation with InterPro:IPR016250

(InterPro Project Members, 2004-)

enables phospholipid binding

inferred from sequence model

(Takeda et al., 2013)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266

(InterPro Project Members, 2004-)

enables protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002521457

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Katzen et al., 1991)

inferred from electronic annotation with InterPro:IPR020635

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in actin filament bundle assembly

inferred from mutant phenotype

(Murray et al., 2006)

involved_in axon guidance

inferred from mutant phenotype

(Murray et al., 2006)

involved_in dorsal closure, amnioserosa morphology change

inferred from mutant phenotype

(Murray et al., 2006)

involved_in dorsal closure, elongation of leading edge cells

inferred from mutant phenotype

(Murray et al., 2006)

involved_in dorsal closure

inferred from genetic interaction with FLYBASE:Src42A; FB:FBgn0264959

(Murray et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

colocalizes_with adherens junction

inferred from direct assay

(Murray et al., 2006)

located_in extrinsic component of cytoplasmic side of plasma membrane

inferred from direct assay

(Paulson et al., 1997)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002521457

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NON-RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (P18106)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein tyrosine kinase activity

RHEA 10596: non-membrane spanning protein tyrosine kinase activity

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) (2.7.10.2)

Summaries

Gene Group (FlyBase)

NON-RECEPTOR TYROSINE KINASES -: Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).

Protein Function (UniProtKB)

(UniProt, P18106)

Summary (Interactive Fly)

Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions - regulates dorsal closure

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\FER for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P18106)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 6.32

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FER-RA

FBtr0082052

NM_079564

4958

1325

FER-RB

FBtr0082051

NM_169274

3395

804

FER-RC

FBtr0082053

NM_169275

2836

475

FER-RD

FBtr0082054

NM_169276

2303

393

FER-RE

FBtr0333295

NM_001275482

3596

871

FER-RF

FBtr0333296

NM_001275483

3599

872

FER-RG

FBtr0479757

NM_001382200

2087

421

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FER-PA

FBpp0081530

150.3

1325

8.09

FBpp0081529

92.4

804

6.76

NP_731341

AAF54366

FER-PC

FBpp0081531

54.2

475

6.30

NP_731342

AAN13420

FER-PD

FBpp0081532

45.2

393

7.06

NP_731343

AAN13421

FER-PE

FBpp0305490

99.9

871

8.17

FBpp0305491

100.0

872

8.17

FBpp0428100

48.2

421

8.15

QJC18447

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FER using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FER_1
FER_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.25

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with adherens junction

inferred from direct assay

(Murray et al., 2006)

located_in extrinsic component of cytoplasmic side of plasma membrane

inferred from direct assay

(Paulson et al., 1997)

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.0}FER^{MI03640-TG4.0}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2018)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FER in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FER

View exonic expression by tissue for Dmel\FER

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000723

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41118/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000723

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000723

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000723

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8874

Flygut - An atlas of the Drosophila adult midgut

FBgn0000723

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FER

Transgenic constructs containing regulatory region of FER

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)FER-Δ1

(Murray et al., 2006)

Df(3R)PX35

(Hill and Bishop, 2005.11)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage

FER^gof

viable

FER^Δex1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

FER^GD14054

viable, with Scer\GAL4^Mef2.PR

FER^GD14054

viable, with Scer\GAL4^pnr-MD237

FER^GD14054

viable, with Scer\GAL4^tin.CΔ4

FER^GD14054

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

FER^HMS00249

fertile

FER^Δex1

Other Phenotypes

Allele

some die during embryonic stage

FER^gof

Phenotype manifest in

Allele

amnioserosa

FER^gof

embryo | dorsal closure stage

FER^gof

embryonic leading edge cell & actomyosin

FER^gof

embryonic leading edge cell & filopodium

FER^gof

ventral midline of embryo

FER^gof

ventral midline of embryo, with FER^gof, Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^RB.UAS

ventral midline of embryo, with FER^RB.UAS, Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^gof

ventral midline of embryo (with FER^gof), with Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^RB.UAS

ventral midline of embryo (with FER^RB.UAS), with Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^gof

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (112)

Hsap\FER

12 of 14

Yes

Hsap\FES

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

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2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Hsap\ALK

1 of 14

Hsap\AXL

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZAP70

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (81)

Rnor\Fer

11 of 14

Yes

Rnor\Fes

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zap70

1 of 14

Mus musculus (laboratory mouse) (86)

Mmus\Fer

12 of 14

Yes

Mmus\Fes

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Vav2

1 of 14

Mmus\Zap70

1 of 14

Xenopus tropicalis (Western clawed frog) (70)

Xtro\fer

10 of 13

Yes

Xtro\fes

9 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\yes1

1 of 13

Xtro\zap70

1 of 13

Danio rerio (Zebrafish) (108)

Drer\fer

11 of 14

Yes

Drer\fes

10 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

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2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ntrk2a

1 of 14

Drer\ntrk2b

1 of 14

Yes

Drer\ntrk3a

1 of 14

Drer\ntrk3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (97)

Cele\kin-14

9 of 14

Yes

Cele\frk-1

8 of 14

Yes

Cele\T21G5.1

8 of 14

Yes

Cele\F59A3.8

6 of 14

Yes

Cele\ZK622.1

6 of 14

Yes

Cele\C25A8.5

5 of 14

Yes

Cele\C55C3.4

5 of 14

Yes

Cele\F22B3.8

5 of 14

Yes

Cele\F23C8.7

5 of 14

Yes

Cele\F57B9.8

5 of 14

Yes

Cele\kin-5

5 of 14

Yes

Cele\kin-26

5 of 14

Yes

Cele\R11E3.1

5 of 14

Yes

Cele\T06C10.3

5 of 14

Yes

Cele\T25B9.4

5 of 14

Yes

Cele\W01B6.5

5 of 14

Yes

Cele\C18H7.4

4 of 14

Yes

Cele\C35E7.10

4 of 14

Yes

Cele\kin-24

4 of 14

Yes

Cele\M176.9

4 of 14

Yes

Cele\R05H5.4

4 of 14

Yes

Cele\ZC581.7

4 of 14

Yes

Cele\abl-1

3 of 14

Cele\kin-21

3 of 14

Yes

Cele\T25B9.5

3 of 14

Yes

Cele\Y43C5B.2

3 of 14

Yes

Cele\Y52D5A.2

3 of 14

Yes

Cele\Y69E1A.3

3 of 14

Yes

Cele\Y116A8C.24

3 of 14

Yes

Cele\Y116A8C.38

3 of 14

Yes

Cele\csk-1

2 of 14

Cele\egl-15

2 of 14

Cele\F26E4.5

2 of 14

Yes

Cele\K09B11.5

2 of 14

Yes

Cele\spe-8

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\T08G5.15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\W04G5.10

1 of 14

Cele\Y4C6A.1

1 of 14

Yes

Cele\Y50D4B.6

1 of 14

Cele\zak-1

1 of 14

Cele\ZK593.9

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (41)

Agam\AgaP_AGAP003651

10 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (42)

Atha\STY8

3 of 13

Yes

Atha\STY17

3 of 13

Yes

Atha\STY46

3 of 13

Yes

Atha\VIK

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Atha\AT1G53440

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G24715

1 of 13

Atha\AT3G46930

1 of 13

Atha\AT3G56050

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\LSB1

1 of 13

Yes

Scer\PIN3

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\skb5

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:FER. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (44)

Abl

7 of 13

Btk

6 of 13

Csk

6 of 13

Src42A

6 of 13

Src64B

6 of 13

Ack

4 of 13

Ack-like

3 of 13

btl

3 of 13

Fak

3 of 13

htl

3 of 13

Shark

3 of 13

Alk

2 of 13

Cad96Ca

2 of 13

Eph

2 of 13

Nrk

2 of 13

Ret

2 of 13

Ror

2 of 13

sev

2 of 13

slpr

2 of 13

cdi

1 of 13

CG3277

1 of 13

CG10702

1 of 13

Cip4

1 of 13

Crk

1 of 13

Ddr

1 of 13

dnt

1 of 13

drk

1 of 13

Drl-2

1 of 13

drl

1 of 13

Egfr

1 of 13

hop

1 of 13

InR

1 of 13

LIMK1

1 of 13

otk2

1 of 13

otk

1 of 13

Pi3K21B

1 of 13

PVRAP

1 of 13

Pvr

1 of 13

Raf

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

FER^HMS00249

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^fl.SCA3.UAS

(Ashraf et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FER; FER tyrosine kinase

12 of 14

176942

FES; FES proto-oncogene, tyrosine kinase

11 of 14

190030

ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase

3 of 14

189980

chronic myeloid leukemia

ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase

3 of 14

164690

MATK; megakaryocyte-associated tyrosine kinase

3 of 14

600038

TXK; TXK tyrosine kinase

3 of 14

600058

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

FER - bsk

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

FER

suppressible

puc

(Murray et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Src42A

enhanceable

FER

(Murray et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66283

DroID - A comprehensive database of gene and protein interactions.

FBgn0000723

MIST (protein-protein) - An integrated Molecular Interaction Database

41118

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P18106

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85D13-85D15

Sequence location

3R:9,367,603..9,394,546 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85D13-85D15

Limits computationally determined from genome sequence between P{lacW}l(3)L4092^L4092 and P{PZ}ps¹⁰⁶¹⁵&P{PZ}Ras85D⁰⁶⁶⁷⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

85D10-85D13

(Paulson, 1996.3.2)

85D10-85D13

(determined by in situ hybridisation)

(Katzen et al., 1991)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-46.1

(Comeron et al., 2012)

(Paulson, 1996.3.2)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

9429

w^*; P{UAS-FER.p92.KM}2

83017

y¹; M{WKO.1-B7}ZH-86Fb

29055

w¹¹¹⁸; Mi{ET1}FER^MB08538

37356

y¹ w^*; Mi{MIC}FER^MI03640

9363

w^*; P{UAS-FER.p45}2; MKRS/TM6B, Tb¹

9364

w^*; P{UAS-FER.p92}2; MKRS/TM6B, Tb¹

9366

w^*; P{UAS-FER.RNAi}SK-2; P{UAS-FER.RNAi}SK-3

9361

w^*; P{lacW}FER^X42/TM6B, Tb¹

9362

w^*; FER^X21, e^s ca¹

FlyORF

F001720

M{UAS-FER.ORF.3xHA}ZH-86Fb

VDRC

v107266

P{KK102022}VIE-260B

v36054

w¹¹¹⁸; P{GD14054}v36054/CyO

More stocks available...

Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (23)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH14840

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000723

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000723

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The 92kD and 45kD Fps85D protein isoforms can transform avian and rodent cells when expressed from retroviral vectors.

(Paulson et al., 1997)

Phylogenetic analysis of the PTK family.

(Suga et al., 1997)

Isolated using an avian v-fps gene fragment as a probe.

(Katzen et al., 1991)

Fps85D has been cloned, sequenced and its expression pattern analysed.

(Katzen et al., 1991)

Relationship to Other Genes

Source for database merge of

Additional comments

Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

(Oates, 1997.11.10)

Nomenclature History

Source for database identify of

Source for identity of: Fps85D CG8874

(Li, 1999.11)

Source for identity of: FER Fps85D

(Paulson et al., 1997)

Nomenclature comments

Etymology

Named "FER" after the human ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CG8874

(Ashraf et al., 2020, Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Murray, 2002.12.6, Morrison et al., 2000)

DFER

(Hill et al., 2001)

DFer

(Van Vactor et al., 1998, Paulson et al., 1997)

Dfer

(Murray et al., 2001)

Dfps

(Oates et al., 1998)

Dm FPS

(Gibson and Spring, 1998)

DmHD-179

(Oates et al., 1998, Oates, 1997.11.10)

FER

(Deshpande et al., 2022, Ding et al., 2022, Guzman et al., 2021, Ashraf et al., 2020, Jevitt et al., 2020, FlyBase Genome Annotators, 2019-, Meltzer et al., 2019, Lopez et al., 2018, Lobell et al., 2017, Gene Disruption Project members, 2016-, Sopko et al., 2014, Bakal et al., 2008, Hill and Bishop, 2004)

FPS

(Morrison et al., 2000, Morrison et al., 2000)

Fer

(Fashena and Zinn, 1997, Gertler et al., 1995)

FpS95D

(Dequéant et al., 2015)

Fps85D

(Hoi et al., 2016, Ashwal-Fluss et al., 2014, Schertel et al., 2013, Sen et al., 2013, Takeda et al., 2013, Yin et al., 2013, Cook et al., 2010.2.12, Mudiganti et al., 2010, Flaherty et al., 2009, Jiang et al., 2009, Liu and Lehmann, 2008, Akdemir et al., 2007, Choksi et al., 2006, Pickeral et al., 2000)

HD-179

dFer

(Juang and Hoffmann, 1999)

dfer

(Murray et al., 2006)

dfps

(Shishido et al., 1991)

dfps 85D

(Jackson, 1990.5.30)

dfps85D

(Paulson et al., 1997, Suga et al., 1997, Katzen et al., 1991, Katzen, 1990)

fer

(Hill, 2001.6.15, Paulson, 1996.3.2)

fps

(Hoffmann, 1991)

fps85D

Name Synonyms

FER ortholog

FER tyrosine kinase

Fps oncogene analog

(Flaherty et al., 2009)

Secondary FlyBase IDs

FBgn0022798

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 79 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41118

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P18106

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P18106

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P18106

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000723

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41118/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000723

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000723

FlyMine - An integrated database for Drosophila genomics

FBgn0000723

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8874

MARRVEL_MODEL - MARRVEL (model organism gene)

41118

Linkouts

BioGRID - A database of protein and genetic interactions.

66283

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000723

DroID - A comprehensive database of gene and protein interactions.

FBgn0000723

DRSC - Results frm RNAi screens

FBgn0000723

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FER_1
FER_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000723

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000723

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8874

Flygut - An atlas of the Drosophila adult midgut

FBgn0000723

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0000723

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031316

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

41118

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P18106

References (99)

The following external sites may use different assemblies or annotations than FlyBase.

-1.25

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