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Gene Dmel\Fps85D

General Information
Symbol	Dmel\Fps85D	Species	D. melanogaster
Name	Fps oncogene analog	Annotation symbol	CG8874
Feature type	protein_coding_gene	FlyBase ID	FBgn0000723
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	FER, Dfer, dfps85D, FPS, DmHD-179, Dfps
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	85D13-85D15	Sequence location	3R:5,193,325..5,220,268 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fps oncogene analog is referred to in FlyBase by the symbol Dmel\Fps85D (CG8874, FBgn0000723). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: dorsal closure, elongation of leading edge cells; dorsal closure; actin filament bundle assembly; axon guidance; photoreceptor cell morphogenesis; dorsal closure, amnioserosa morphology change. 20 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; amnioserosa; ventral midline. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: FCH domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval trachea, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639139_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Fps85D. Gene sequence location is 3R:5193325..5220268.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85D13-85D15   Limits computationally determined from genome sequence between P{lacW}l(3)L4092L4092 and P{PZ}ps10615&P{PZ}Ras85D06677
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85D10-85D13     (Paulson, 1996.3.2) 85D10-85D13   (determined by in situ hybridisation)   (Katzen et al., 1991)
Experimentally Determined Recombination Data
Location	3- (Paulson, 1996.3.2)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fps85D for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fps85D-RA FBtr0082052  NM_079564   4958   1325 Fps85D-RB FBtr0082051  NM_169274   3395   804 Fps85D-RC FBtr0082053  NM_169275   2836   475 Fps85D-RD FBtr0082054  NM_169276   2303   393 Fps85D-RE FBtr0333295  NM_001275482   3596   871 Fps85D-RF FBtr0333296  NM_001275483   3599   872
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fps85D-PA   FBpp0081530   150.3   1325   8.09     NP_524288   AAF54367 Fps85D-PB   FBpp0081529   92.4   804   6.76     NP_731341   AAF54366 Fps85D-PC   FBpp0081531   54.2   475   6.30     NP_731342   AAN13420 Fps85D-PD   FBpp0081532   45.2   393   7.06     NP_731343   AAN13421 Fps85D-PE   FBpp0305490   99.9   871   8.17     NP_001262411   AGB95793 Fps85D-PF   FBpp0305491   100.0   872   8.17     NP_001262412   AGB95794
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) SH2 domain (IPR000980) FCH domain (IPR001060) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567983   AA567993   AE014297 AAF54366   AE014297 AAF54367   AE014297 AAN13420   AE014297 AAN13421   AF392049 AAL60138   AE014297 AGB95793   AE014297 AGB95794   AI386997   AI389640   AJ002916 CAA05751   BF488438   BF493513   BF493514   BF502217   BF503330   BF503380   BG636301   BI233315   BI367838   BI609980   BI639833   BP554539   BP554540   BT003462 AAO39465   CK661333   CO154156   CO183324   CO189511   CO263091   CO266327   CO275902   CO288959   CO297236   CO297633   CO301092   CO310775   CO315545   EC054801   EC055439   EC055892   EC057208   EC057833   EC059233   EC059486   EC073026   EC089957   EC196805   EC203910   EC213745   EC216374   EC220323   EC223080   EC245850   EC247776   EC262785   EL877706   EV595343   U50450 AAA93470   X52844 CAA37036
UniProtKB/Swiss-Prot	P18106
UniProtKB/TrEMBL	Q8WRX4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435225 3R:5,200,244..5,201,243 evidence=Reporter construct (in vivo) (Rouault et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
adherens junction inferred from direct assay (Murray et al., 2006) plasma membrane inferred from direct assay (Paulson et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval trachea, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye    679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop    707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules    500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye  (679.5) Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop  (707.4) Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules  500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye    679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop    707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules    500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye    679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop    707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules    500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye    679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop    707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules    500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye  679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop  707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules  500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye    679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop    707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules    500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    206.475 Larval Midgut    227.9 Larval Hindgut    350.4 Larval Malpighian Tubules    370.5 Larval Fat Body    63 Larval Salivary Gland    61 Larval Trachea    201.75 Larval Carcass    439.7 Adult Head    214.4 Adult Eye    679.5 Adult Brain    98.9 Adult Thoracic-Abdominal Ganglion    128.9 Adult Crop    707.4 Adult Midgut    224.3 Adult Hindgut    494.9 Adult Malpighian Tubules    500.9 Adult Fat Body    94.4 Adult Salivary Gland    71.4 Adult Heart    216.2 Adult VirginFemale Spermatheca    75.5 Adult InseminatedFemale Spermatheca    96.9 Adult Ovary    19.8 Adult Testis    35.5 Adult Male Accessory Gland    134.5 Adult Carcass    196.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    214.4   NA  Eye    679.5   NA  Brain    98.9   206.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    128.9   NA  Crop    707.4   227.9  Midgut    224.3   350.4  Hindgut    494.9   370.5  Malpighian Tubules    500.9   63  Fat Body    94.4   61  Salivary Gland    71.4   NA  Heart    216.2   201.75  Trachea    NA   NA  VirginFemale Spermatheca    75.5   NA  InseminatedFemale Spermatheca    96.9   NA  Ovary    19.8   NA  Testis    35.5   NA  Male Accessory Gland    134.5   439.7  Carcass    196.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male    26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male  26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male    26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male    26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male    26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male  26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male    26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    20 central nervous system, pupae P8    13 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    10 head, mated 1-day female    19 head, mated 4-day female    15 head, mated 20-day female    10 head, mated 1-day male    26 head, mated 4-day male    25 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    12 carcass, larvae L3 wandering    15 carcass, 1-day adult    9 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    26 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP  26 pupae 3d postWPP  (27) pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    26 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    26 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    26 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP  26 pupae 3d postWPP  27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    26 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    14 embryo 08-10hr    18 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    13 embryo 22-24hr    13 larva L1    8 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    17 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    26 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    21 adult male 05day    24 adult male 30day    23 adult female 01day    11 adult female 05day    5 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    56 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3    36 leg disc CME L1    53 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    30 ovary fGS/OSS    35 ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4  (56) embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3  (36) leg disc CME L1  (53) wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2  (30) ovary fGS/OSS  (35) ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    56 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3    36 leg disc CME L1    53 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    30 ovary fGS/OSS    35 ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    56 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3    36 leg disc CME L1    53 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    30 ovary fGS/OSS    35 ovary OSC    18 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    56 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3    36 leg disc CME L1    53 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    30 ovary fGS/OSS    35 ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4  (56) embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3  (36) leg disc CME L1  (53) wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2  30 ovary fGS/OSS  (35) ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    56 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3    36 leg disc CME L1    53 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    30 ovary fGS/OSS    35 ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    56 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    6 embryonic S1    14 embryonic S3    36 leg disc CME L1    53 wing disc CME-W2    10 wing disc ML-DmD8    20 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    6 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    30 ovary fGS/OSS    35 ovary OSC    18 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • RH14840 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000723 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8874-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage Fps85Dgof viable Fps85DΔex1 viable, with Scer\GAL4pnr-MD237 Fps85DGD14054 Sterility Allele fertile Fps85DΔex1 Phenotype manifest in Allele amnioserosa Fps85Dgof dorsal closure embryo Fps85Dgof embryonic leading edge cell & actomyosin Fps85Dgof embryonic leading edge cell & filopodium Fps85Dgof ventral midline Fps85Dgof ventral midline, with Fps85Dgof, Scer\GAL4da.G32, Scer\GAL4wex1.for, Scer\GAL4wex1.rev Fps85DRB.Scer\UAS ventral midline, with Fps85DRB.Scer\UAS, Scer\GAL4da.G32, Scer\GAL4wex1.for, Scer\GAL4wex1.rev Fps85Dgof ventral midline (with Fps85Dgof), with Scer\GAL4da.G32, Scer\GAL4wex1.for, Scer\GAL4wex1.rev Fps85DRB.Scer\UAS ventral midline (with Fps85DRB.Scer\UAS), with Scer\GAL4da.G32, Scer\GAL4wex1.for, Scer\GAL4wex1.rev Fps85Dgof
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Fps85D Class Mutagen Stocks Known lesion Fps85DE134 1 Yes Fps85Df04954 1 -- Fps85DMB08538 1 -- Fps85DMI03640 1 -- Fps85DX21 loss of function allele X ray 1 Yes Fps85DX42 X ray 1 Yes Fps85DB363 0 -- Fps85Dgof gain of function allele P-element activity 0 Yes Fps85DΔex1 hypomorphic allele - genetic evidence P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fps85D Class Mutagen Stocks Known lesion Fps85DGD14054 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Fps85DdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Fps85DHMS00249 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fps85DKK102022 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fps85Dp100.Scer\UAS in vitro construct - regulatory fusion 1 Yes Fps85Dp45.Scer\UAS in vitro construct - regulatory fusion 1 Yes Fps85Dp92.KM.Scer\UAS in vitro construct - regulatory fusion in vitro construct 1 Yes Fps85Dp92.Scer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Fps85Dp92.Scer\UAS in vitro construct - regulatory fusion 1 Yes Fps85DAct5C.PG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes Fps85DRB.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Fps85D-Δ1 (Murray et al., 2006) Df(3R)PX35 (Hill and Bishop, 2005.11)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14054} NA P{KK102022} NA P{TRiP.HMS00249} NA P{UAS-DFer.DB} NA P{UAS-Fps85D.dsRNA} NA P{UAS-Fps85D.p45} NA P{UAS-Fps85D.p92.KM} NA P{UAS-Fps85D.p92.myr} NA P{UAS-Fps85D.p92} NA P{UAS-Fps85D.p100} NA characterization construct P{GawB-wex1} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Fps85DMI03640 NA P{?lacW}Fps85DX21 NA P{GawB-wex1}Fps85Dgof NA PBac{5HPw+}Fps85DB363 NA PBac{WH}Fps85Df04954 NA insertion of enhancer trap binary system Mi{ET1}Fps85DMB08538 No P{GawB}Fps85DΔex1 No P{GawB}MZ465 No insertion of enhancer trap P{lacW}Fps85DE134 No P{lacW}Fps85DX42 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament bundle assembly inferred from mutant phenotype (Murray et al., 2006) axon guidance inferred from mutant phenotype (Murray et al., 2006) dorsal closure inferred from genetic interaction with Src42A (Murray et al., 2006) dorsal closure, amnioserosa morphology change inferred from mutant phenotype (Murray et al., 2006) dorsal closure, elongation of leading edge cells inferred from mutant phenotype (Murray et al., 2006) photoreceptor cell morphogenesis inferred from mutant phenotype (Hill et al., 2001)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Murray et al., 2006) plasma membrane inferred from direct assay (Paulson et al., 1997)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity inferred from sequence or structural similarity (Katzen et al., 1991) inferred from sequence or structural similarity with UniProtKB:P00541 (FlyBase, 1992-) non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000, Swiss-Prot Project Members, 1990.11.1)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Hill, 2001.6.15) membrane non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fps85D allele Gene References unspecified puc (Murray et al., 2006) Src42A (Murray et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66283 DroID - A comprehensive database of gene and protein interactions. • FBgn0000723 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41118 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18106
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6V17K4 Dipteran inclusive ortholog search EOG6XPQPW Insect inclusive ortholog search EOG6SF81S Arthropod inclusive ortholog search EOG602V74 Metazoa inclusive ortholog search EOG6W195V
Orthologs in Drosophila Species (EOG6V17K4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Fps85D     Drosophila simulans   Dsim\GD20803 Y   Drosophila sechellia   Dsec\GM26266 Y   Drosophila erecta   Dere\GG17381 Y   Drosophila yakuba   Dyak\GE24784 Y   Drosophila ananassae   Dana\GF17770 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21383 Y   Drosophila persimilis   Dper\GL13676 Y   Drosophila willistoni   Dwil\GK11727 Y   Drosophila virilis   Dvir\GJ23577 Y   Drosophila mojavensis   Dmoj\GI23604 Y   Drosophila grimshawi   Dgri\GH18554 Y
Orthologs in non-Drosophila Dipterans (EOG6XPQPW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014512   Anopheles gambiae Malaria mosquito  Agam\AGAP003651   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005385
Orthologs in non-Dipteran Insects (EOG6SF81S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44062   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009189   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19479   Atta cephalotes Leafcutter ant  Acep\ACEP16335   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22021   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13027   Linepithema humile Argentine ant  Lhum\LH23606   Linepithema humile Argentine ant  Lhum\LH23611   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24250   Solenopsis invicta Red fire ant  Sinv\SINV14948   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001777   Bombyx mori Silkmoth  Bmor\BGIBMGA006417   Pediculus humanus Human body louse  Phum\PHUM259640   Tribolium castaneum Red flour beetle  Tcas\TC004367
Orthologs in non-Insect Arthropods (EOG602V74)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW019316
Orthologs in non-Arthropod Metazoa (EOG6W195V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\kin-14   Caenorhabditis elegans Nematode  Cele\T21G5.1   Caenorhabditis elegans Nematode  Cele\ZK622.1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20803 Drosophila sechellia Dsec\GM26266 Drosophila erecta Dere\GG17381 Drosophila yakuba Dyak\GE24784 Drosophila ananassae Dana\GF17770 Drosophila pseudoobscura pseudoobscura Dpse\GA21383 Drosophila persimilis Dper\GL13676 Drosophila willistoni Dwil\GK11727 Drosophila virilis Dvir\GJ23577 Drosophila mojavensis Dmoj\GI23604 Drosophila grimshawi Dgri\GH18554
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	9429 w*; P{UAS-Fps85D.p92.KM}2 9359 w*; P{lacW}Fps85DE134 29055 w1118; Mi{ET1}Fps85DMB08538 37356 y1 w*; Mi{MIC}Fps85DMI03640 9363 w*; P{UAS-Fps85D.p45}2; MKRS/TM6B, Tb1 9364 w*; P{UAS-Fps85D.p92}2; MKRS/TM6B, Tb1 9361 w*; P{lacW}Fps85DX42/TM6B, Tb1 9362 w*; Fps85DX21, es ca1
Harvard	- PBac{WH}Fps85Df04954
VDRC	v107266 P{KK102022}VIE-260B v36053 w1118; P{GD14054}v36053/TM3 v36054 w1118; P{GD14054}v36054/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR19J06 BACR32M04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH14840
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17877 AT19293 AT19350 AT23718 GH17404 GH20864 HL02082 HL02094 LP20758 RE53686 SD13939 SD22527
Other clones	AT01796 Dmel_neb_015175_0579_3610 EC25462 EC054801 EC055439 EC055892 EK044433 EK069745 EK087430 EK119064 EK146042 EK170236 EK180045 EK216440 EK222505 EK261814 EN03616 FGM230D08 IP07683 RE29626
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000723 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41118
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Fps85D CG8874 (Li, 1999.11)
Source for database merge of
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The 92kD and 45kD Fps85D protein isoforms can transform avian and rodent cells when expressed from retroviral vectors. (Paulson et al., 1997) Phylogenetic analysis of the PTK family. (Suga et al., 1997) Isolated using an avian v-fps gene fragment as a probe. (Katzen et al., 1991) Fps85D has been cloned, sequenced and its expression pattern analysed. (Katzen et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079564 NM_169274 NM_169275 NM_169276 NM_001275482 NM_001275483 RefSeq (Proteins) • NP_524288 NP_731341 NP_731342 NP_731343 NP_001262411 NP_001262412 DDBJ / EMBL / GenBank • AAA93470 AAF54366 AAF54367 AAL60138 AAN13420 AAN13421 AAO39465 AF392049 AGB95793 AGB95794 AJ002916 BF493513 BF493514 BI609980 BT003462 CAA05751 CAA37036 U50450 X52844 Entrez Gene - A searchable database of RefSeq genes. • 41118 UniProtKB/Swiss-Prot • P18106 UniProtKB/TrEMBL • Q8WRX4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) SH2 domain (IPR000980) FCH domain (IPR001060) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH14840
Linkouts
	BioGRID - A database of protein and genetic interactions • 66283 DroID - A comprehensive database of gene and protein interactions. • FBgn0000723 DRSC - Results from RNAi screens. • FBgn0000723 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000723 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8874-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000723 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41118 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/fps_fer1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41118 modMine - Data generated by the modENCODE project. • FBgn0000723 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18106
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	CG8874 (Murray, 2002.12.6, Morrison et al., 2000, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) Dfer (Murray et al., 2001, ) DFER (Hill et al., 2001) dFer (Juang and Hoffmann, 1999) DFer (Van Vactor et al., 1998, Paulson et al., 1997) dfer (Murray et al., 2006) Dfps (Oates et al., 1998) dfps (Shishido et al., 1991) dfps 85D (Jackson, 1990.5.30) dfps85D (Suga et al., 1997, Paulson et al., 1997, Katzen et al., 1991, Katzen, 1990) Dm FPS (Gibson and Spring, 1998) DmHD-179 (Oates, 1997.11.10, Oates et al., 1998, ) FER (Hill and Bishop, 2004, Bakal et al., 2008) fer (Hill, 2001.6.15, Paulson, 1996.3.2, ) Fer (Fashena and Zinn, 1997, Gertler et al., 1995) FPS (Morrison et al., 2000, Morrison et al., 2000) fps (Hoffmann, 1991) fps85D   Fps85D (Akdemir et al., 2007, Liu and Lehmann, 2008, Jiang et al., 2009, Mudiganti et al., 2010, Choksi et al., 2006, Flaherty et al., 2009, Cook et al., 2010.2.12) HD-179
Name Synonym	Fps oncogene analog (Flaherty et al., 2009)
Secondary FlyBase IDs
	FBgn0022798
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Thesis  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 )
Recent research papers (0)
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Recent reviews (0)
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