FlyBase Gene Report: Dmel\FER

General Information

Symbol

Dmel\FER

Species

D. melanogaster

Name

FER tyrosine kinase

Annotation Symbol

CG8874

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000723

Gene Model Status

Current

Stock Availability

17 publicly available

Enzyme Name (EC)

Non-specific protein-tyrosine kinase (2.7.10.2)

Gene Summary

Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm. (UniProt, P18106)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Fps85D, dfps85D, DmHD-179, Fps oncogene analog, FPS

Key Links

Genomic Location

Cytogenetic map

85D13-85D15

Sequence location

3R:9,367,603..9,394,546 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:9367603..9394546

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables non-membrane spanning protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

enables phospholipid binding

inferred from sequence model

(Takeda et al., 2013)

enables protein tyrosine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN002521457

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Katzen et al., 1991)

enables signaling receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in actin filament bundle assembly

inferred from mutant phenotype

(Murray et al., 2006)

involved_in axon guidance

inferred from mutant phenotype

(Murray et al., 2006)

involved_in dorsal closure, amnioserosa morphology change

inferred from mutant phenotype

(Murray et al., 2006)

involved_in dorsal closure, elongation of leading edge cells

inferred from mutant phenotype

(Murray et al., 2006)

involved_in dorsal closure

inferred from genetic interaction with FLYBASE:Src42A; FB:FBgn0264959

(Murray et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in innate immune response

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in peptidyl-tyrosine phosphorylation

inferred from electronic annotation with InterPro:IPR016250

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in transmembrane receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

colocalizes_with adherens junction

inferred from direct assay

(Murray et al., 2006)

located_in extrinsic component of membrane

inferred from direct assay

(Paulson et al., 1997)

located_in plasma membrane

inferred from direct assay

(Paulson et al., 1997)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extrinsic component of cytoplasmic side of plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002521528

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NON-RECEPTOR TYROSINE KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (P18106)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.2)

Summaries

Gene Group (FlyBase)

NON-RECEPTOR TYROSINE KINASES -: Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).

Protein Function (UniProtKB)

(UniProt, P18106)

Summary (Interactive Fly)

Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions - regulates dorsal closure

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\FER for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FER-RA

FBtr0082052

NM_079564

4958

1325

FER-RB

FBtr0082051

NM_169274

3395

804

FER-RC

FBtr0082053

NM_169275

2836

475

FER-RD

FBtr0082054

NM_169276

2303

393

FER-RE

FBtr0333295

NM_001275482

3596

871

FER-RF

FBtr0333296

NM_001275483

3599

872

FER-RG

FBtr0479757

NM_001382200

2087

421

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FER-PA

FBpp0081530

150.3

1325

8.09

NP_524288

AAF54367

FER-PB

FBpp0081529

92.4

804

6.76

NP_731341

AAF54366

FER-PC

FBpp0081531

54.2

475

6.30

NP_731342

AAN13420

FER-PD

FBpp0081532

45.2

393

7.06

NP_731343

AAN13421

FER-PE

FBpp0305490

99.9

871

8.17

NP_001262411

AGB95793

FER-PF

FBpp0305491

100.0

872

8.17

NP_001262412

AGB95794

FER-PG

FBpp0428100

48.2

421

8.15

QJC18447

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FER using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FER_1
FER_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with adherens junction

inferred from direct assay

(Murray et al., 2006)

located_in extrinsic component of membrane

inferred from direct assay

(Paulson et al., 1997)

located_in plasma membrane

inferred from direct assay

(Paulson et al., 1997)

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.0}FER^{MI03640-TG4.0}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2018)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\FER in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FER

View exonic expression by tissue for Dmel\FER

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000723

DRscDB

41118/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0000723

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG8874-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8874

Flygut - An atlas of the Drosophila adult midgut

FBgn0000723

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FER

Transgenic constructs containing regulatory region of FER

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)FER-Δ1

(Murray et al., 2006)

Df(3R)PX35

(Hill and Bishop, 2005.11)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage

FER^gof

viable

FER^Δex1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

FER^GD14054

viable, with Scer\GAL4^Mef2.PR

FER^GD14054

viable, with Scer\GAL4^pnr-MD237

FER^GD14054

viable, with Scer\GAL4^tin.CΔ4

FER^GD14054

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

FER^HMS00249

fertile

FER^Δex1

Other Phenotypes

Allele

some die during embryonic stage

FER^gof

Phenotype manifest in

Allele

amnioserosa

FER^gof

embryo | dorsal closure stage

FER^gof

embryonic leading edge cell & actomyosin

FER^gof

embryonic leading edge cell & filopodium

FER^gof

ventral midline of embryo

FER^gof

ventral midline of embryo, with FER^gof, Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^RB.UAS

ventral midline of embryo, with FER^RB.UAS, Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^gof

ventral midline of embryo (with FER^gof), with Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^RB.UAS

ventral midline of embryo (with FER^RB.UAS), with Scer\GAL4^da.G32, Scer\GAL4^wex1.for, Scer\GAL4^wex1.rev

FER^gof

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\FER

12 of 15

Yes

Hsap\FES

11 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Fer

13 of 15

Yes

Mmus\Fes

10 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Fer

10 of 13

Yes

Rnor\Fes

10 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\fes

10 of 12

Yes

Xtro\fer

7 of 12

Yes

Xtro\LOC100490493

1 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\fes

11 of 15

Yes

Drer\fer

9 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (41)

Cele\frk-1

10 of 15

Yes

Cele\kin-14

9 of 15

Yes

Cele\T21G5.1

6 of 15

Yes

Cele\kin-24

5 of 15

Yes

Cele\F26E4.5

4 of 15

Yes

Cele\F59A3.8

4 of 15

Yes

Cele\K09B11.5

4 of 15

Yes

Cele\kin-21

4 of 15

Yes

Cele\spe-8

4 of 15

Yes

Cele\T25B9.5

4 of 15

Yes

Cele\Y52D5A.2

4 of 15

Yes

Cele\Y69E1A.3

4 of 15

Yes

Cele\Y116A8C.24

4 of 15

Yes

Cele\ZK622.1

4 of 15

Yes

Cele\C25A8.5

3 of 15

Yes

Cele\C35E7.10

3 of 15

Yes

Cele\C55C3.4

3 of 15

Yes

Cele\F22B3.8

3 of 15

Yes

Cele\F23C8.7

3 of 15

Yes

Cele\F57B9.8

3 of 15

Yes

Cele\kin-5

3 of 15

Yes

Cele\kin-6

3 of 15

Yes

Cele\kin-26

3 of 15

Yes

Cele\R05H5.4

3 of 15

Yes

Cele\R11E3.1

3 of 15

Yes

Cele\T06C10.3

3 of 15

Yes

Cele\T25B9.4

3 of 15

Yes

Cele\W01B6.5

3 of 15

Yes

Cele\Y116A8C.38

3 of 15

Yes

Cele\ZC581.7

3 of 15

Yes

Cele\C18H7.4

2 of 15

Yes

Cele\kin-31

2 of 15

Yes

Cele\W03F8.2

2 of 15

Yes

Cele\Y4C6A.1

2 of 15

Yes

Cele\Y43C5B.2

2 of 15

Yes

Cele\ZK593.9

2 of 15

Yes

Cele\C34F11.5

1 of 15

Cele\F01D4.3

1 of 15

Yes

Cele\M176.9

1 of 15

Yes

Cele\T08G5.2

1 of 15

Yes

Cele\T08G5.15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (16)

Atha\AT2G19230

1 of 9

Yes

Atha\AT3G22750

1 of 9

Yes

Atha\AT3G50730

1 of 9

Yes

Atha\AT4G14780

1 of 9

Yes

Atha\AT5G01850

1 of 9

Yes

Atha\AT5G40540

1 of 9

Yes

Atha\AT5G47070

1 of 9

Yes

Atha\AT5G50000

1 of 9

Yes

Atha\AT5G50180

1 of 9

Yes

Atha\AT5G57610

1 of 9

Yes

Atha\AT5G66710

1 of 9

Yes

Atha\ATMRK1

1 of 9

Yes

Atha\ATN1

1 of 9

Yes

Atha\HT1

1 of 9

Yes

Atha\RKF1

1 of 9

Yes

Atha\VIK

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\ppk1

1 of 12

Yes

Spom\shk1

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919018J )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21383

Drosophila persimilis

Dper\GL13676

Drosophila willistoni

Dwil\GK11727

Drosophila virilis

Dvir\GJ23577

Drosophila mojavensis

Dmoj\GI23604

Drosophila grimshawi

Dgri\GH18554

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500OQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17020852

Musca domestica

House fly

Mdoa\17007298

Glossina morsitans

Tsetse fly

Gmor\GMOY002025

Mayetiola destructor

Hessian fly

Mdes\Mdes014172

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014512

Anopheles darlingi

American malaria mosquito

Adar\ADAC004454

Anopheles gambiae

Malaria mosquito

Agam\AGAP003651

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005385

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01NV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006417

Bombyx mori

Silkmoth

Bmor\BGIBMGA006416

Danaus plexippus

Monarch butterfly

Dple\DPOGS208227-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008372

Heliconius melpomene

Postman butterfly

Hmel\HMEL008373

Apis florea

Little honeybee

Aflo\2323814004

Apis mellifera

Western honey bee

Amel\GB44062

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21347

Bombus terrestris

Buff-tailed bumblebee

Bter\15215839

Linepithema humile

Argentine ant

Lhum\LH23611

Linepithema humile

Argentine ant

Lhum\LH23606

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002168

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009189

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02601

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00598

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00600

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00599

Tribolium castaneum

Red flour beetle

Tcas\TC031316

Pediculus humanus

Human body louse

Phum\PHUM259640

Rhodnius prolixus

Kissing bug

Rpro\RPRC008886

Rhodnius prolixus

Kissing bug

Rpro\RPRC010636

Cimex lectularius

Bed bug

Clec\CLEC003718

Cimex lectularius

Bed bug

Clec\CLEC003719

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001777

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03551

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01WQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008218

Ixodes scapularis

Black-legged tick

Isca\ISCW019316

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79159.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74587.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79156.1

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (11)

Gene Symbol

Score

Source

Alignment

Abl

2 of 10

Ack

2 of 10

Ack-like

2 of 10

Btk29A

2 of 10

Csk

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Fak

1 of 10

Wsck

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FER; FER tyrosine kinase

12 of 15

176942

FES; FES proto-oncogene, tyrosine kinase

11 of 15

190030

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

FER - bsk

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

FER

suppressible

puc

(Murray et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Src42A

enhanceable

FER

(Murray et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66283

DroID - A comprehensive database of gene and protein interactions.

FBgn0000723

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41118

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85D13-85D15

Sequence location

3R:9,367,603..9,394,546 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85D13-85D15

Limits computationally determined from genome sequence between P{lacW}l(3)L4092^L4092 and P{PZ}ps¹⁰⁶¹⁵&P{PZ}Ras85D⁰⁶⁶⁷⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

85D10-85D13

(Paulson, 1996.3.2)

85D10-85D13

(determined by in situ hybridisation)

(Katzen et al., 1991)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-46.1

(Comeron et al., 2012)

(Paulson, 1996.3.2)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Bloomington

9429

w^*; P{UAS-FER.p92.KM}2

83017

y¹; M{WKO.1-B7}ZH-86Fb

29055

w¹¹¹⁸; Mi{ET1}FER^MB08538

37356

y¹ w^*; Mi{MIC}FER^MI03640

9363

w^*; P{UAS-FER.p45}2; MKRS/TM6B, Tb¹

9364

w^*; P{UAS-FER.p92}2; MKRS/TM6B, Tb¹

9361

w^*; P{lacW}FER^X42/TM6B, Tb¹

9362

w^*; FER^X21, e^s ca¹

9365

w^*; P{UAS-FER.p100}2; MKRS/TM6B, Tb¹

FlyORF

F001720

M{UAS-FER.ORF.3xHA}ZH-86Fb

VDRC

v107266

P{KK102022}VIE-260B

v36054

w¹¹¹⁸; P{GD14054}v36054/CyO

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Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH14840

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000723

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000723

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41118

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Fps85D CG8874

(Li, 1999.11)

Source for identity of: FER Fps85D

(Paulson et al., 1997)

Source for database merge of

Additional comments

Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

(Oates, 1997.11.10)

Other Comments

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The 92kD and 45kD Fps85D protein isoforms can transform avian and rodent cells when expressed from retroviral vectors.

(Paulson et al., 1997)

Phylogenetic analysis of the PTK family.

(Suga et al., 1997)

Isolated using an avian v-fps gene fragment as a probe.

(Katzen et al., 1991)

Fps85D has been cloned, sequenced and its expression pattern analysed.

(Katzen et al., 1991)

Origin and Etymology

Discoverer

Etymology

Named "FER" after the human ortholog.

(FlyBase, 2009-)

Identification

External Crossreferences and Linkouts ( 75 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41118

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P18106

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000723

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000723

DRscDB

41118/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0000723

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FER_1
FER_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8874

Flygut - An atlas of the Drosophila adult midgut

FBgn0000723

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

41118

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031316

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8874

MARRVEL_MODEL

41118

modMine - A data warehouse for the modENCODE project

FBgn0000723

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P18106

Linkouts

BioGRID - A database of protein and genetic interactions.

66283

DroID - A comprehensive database of gene and protein interactions.

FBgn0000723

DRSC - Results frm RNAi screens

FBgn0000723

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG8874-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000723

FlyMine - An integrated database for Drosophila genomics

FBgn0000723

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

41118

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

CG8874

(Ashraf et al., 2020, Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Murray, 2002.12.6, Morrison et al., 2000)

DFER

(Hill et al., 2001)

DFer

(Van Vactor et al., 1998, Paulson et al., 1997)

Dfer

(Murray et al., 2001)

Dfps

(Oates et al., 1998)

Dm FPS

(Gibson and Spring, 1998)

DmHD-179

(Oates et al., 1998, Oates, 1997.11.10)

FER

(Guzman et al., 2021, Ashraf et al., 2020, Jevitt et al., 2020, FlyBase Genome Annotators, 2019-, Meltzer et al., 2019, Lopez et al., 2018, Lobell et al., 2017, Gene Disruption Project members, 2016-, Sopko et al., 2014, Bakal et al., 2008, Hill and Bishop, 2004)

FPS

(Morrison et al., 2000, Morrison et al., 2000)

Fer

(Fashena and Zinn, 1997, Gertler et al., 1995)

FpS95D

(Dequéant et al., 2015)

Fps85D

(Hoi et al., 2016, Ashwal-Fluss et al., 2014, Schertel et al., 2013, Sen et al., 2013, Takeda et al., 2013, Yin et al., 2013, Cook et al., 2010.2.12, Mudiganti et al., 2010, Flaherty et al., 2009, Jiang et al., 2009, Liu and Lehmann, 2008, Akdemir et al., 2007, Choksi et al., 2006, Pickeral et al., 2000)

HD-179

dFer

(Juang and Hoffmann, 1999)

dfer

(Murray et al., 2006)

dfps

(Shishido et al., 1991)

dfps 85D

(Jackson, 1990.5.30)

dfps85D

(Paulson et al., 1997, Suga et al., 1997, Katzen et al., 1991, Katzen, 1990)

fer

(Hill, 2001.6.15, Paulson, 1996.3.2)

fps

(Hoffmann, 1991)

fps85D

Name Synonyms

FER ortholog

FER tyrosine kinase

Fps oncogene analog

(Flaherty et al., 2009)

Secondary FlyBase IDs

FBgn0022798

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (96)

Report Sections

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