FB2020_03, released Jun 16, 2020

Gene: Dmel\FER

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General Information
Symbol
Dmel\FER
Species
D. melanogaster
Name
FER tyrosine kinase
Annotation Symbol
CG8874
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000723
Gene Model Status
Current
Stock Availability
18 publicly available
Enzyme Name (EC)
Non-specific protein-tyrosine kinase (2.7.10.2)
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

Fps85D, dfps85D, DmHD-179, FPS, Dfer

Key Links
Genomic Location
Cytogenetic map
85D13-85D15
Sequence location
3R:9,367,603..9,394,546 [-]
Recombination map

3-48

RefSeq locus
NT_033777 REGION:9367603..9394546
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
non-membrane spanning protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
phospholipid binding
inferred from sequence model
(Takeda et al., 2013)
protein tyrosine kinase activity
inferred from sequence or structural similarity
(Katzen et al., 1991)
signaling receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
actin filament bundle assembly
inferred from mutant phenotype
(Murray et al., 2006)
axon guidance
inferred from mutant phenotype
(Murray et al., 2006)
dorsal closure
inferred from genetic interaction with FLYBASE:Src42A; FB:FBgn0264959
(Murray et al., 2006)
dorsal closure, amnioserosa morphology change
inferred from mutant phenotype
(Murray et al., 2006)
dorsal closure, elongation of leading edge cells
inferred from mutant phenotype
(Murray et al., 2006)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
cell migration
inferred from biological aspect of ancestor with PANTHER:PTN002400919
(assigned by GO_Central )
(Gaudet et al., 2011)
peptidyl-tyrosine autophosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
(Murray et al., 2006)
extrinsic component of membrane
inferred from direct assay
(Paulson et al., 1997)
plasma membrane
inferred from direct assay
(Paulson et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
extrinsic component of cytoplasmic side of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002521528
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (P18106)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.2)
Summaries
Gene Group (FlyBase)
NON-RECEPTOR TYROSINE KINASES -
Non-Receptor Tyrosine kinases (nRTK) are cytoplasmic protein kinases that specifically phosphorylate tyrosine residues. nRTKs are involved in signalling cascades and possess targeting domains such as SH2 domains. (Adapted from FBrf0132098).
Protein Function (UniProtKB)
Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm.
(UniProt, P18106)
Summary (Interactive Fly)

Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions - regulates dorsal closure

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\FER or the JBrowse view of Dmel\FER for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FER-RA
FBtr0082052
NM_079564
4958
1325
FER-RB
FBtr0082051
NM_169274
3395
804
FER-RC
FBtr0082053
NM_169275
2836
475
FER-RD
FBtr0082054
NM_169276
2303
393
FER-RE
FBtr0333295
NM_001275482
3596
871
FER-RF
FBtr0333296
NM_001275483
3599
872
FER-RG
FBtr0479757
NM_001382200
2087
421
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FER-PA
FBpp0081530
150.3
1325
8.09
NP_524288
AAF54367
FER-PB
FBpp0081529
92.4
804
6.76
NP_731341
AAF54366
FER-PC
FBpp0081531
54.2
475
6.30
NP_731342
AAN13420
FER-PD
FBpp0081532
45.2
393
7.06
NP_731343
AAN13421
FER-PE
FBpp0305490
99.9
871
8.17
NP_001262411
AGB95793
FER-PF
FBpp0305491
100.0
872
8.17
NP_001262412
AGB95794
FER-PG
FBpp0428100
48.2
421
8.15
QJC18447
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FER using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
eye
(Xu et al., 2004)
Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with adherens junction
inferred from direct assay
(Murray et al., 2006)
extrinsic component of membrane
inferred from direct assay
(Paulson et al., 1997)
plasma membrane
inferred from direct assay
(Paulson et al., 1997)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.0}FERMI03640-TG4.0
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\FER in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of FER
Transgenic constructs containing regulatory region of FER
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FER
12 of 15
Yes
Yes
Hsap\FES
11 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Fer
13 of 15
Yes
Yes
Mmus\Fes
10 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Fer
10 of 13
Yes
Yes
Rnor\Fes
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\fes
10 of 12
Yes
Yes
Xtro\fer
7 of 12
No
Yes
Xtro\LOC100490493
1 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\fes
11 of 15
Yes
Yes
Drer\fer
9 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (41)
Cele\frk-1
10 of 15
Yes
Yes
Cele\kin-14
9 of 15
No
Yes
Cele\T21G5.1
6 of 15
No
Yes
Cele\kin-24
5 of 15
No
Yes
Cele\F26E4.5
4 of 15
No
Yes
Cele\F59A3.8
4 of 15
No
Yes
Cele\K09B11.5
4 of 15
No
Yes
Cele\kin-21
4 of 15
No
Yes
Cele\spe-8
4 of 15
No
Yes
Cele\T25B9.5
4 of 15
No
Yes
Cele\Y52D5A.2
4 of 15
No
Yes
Cele\Y69E1A.3
4 of 15
No
Yes
Cele\Y116A8C.24
4 of 15
No
Yes
Cele\ZK622.1
4 of 15
No
Yes
Cele\C25A8.5
3 of 15
No
Yes
Cele\C35E7.10
3 of 15
No
Yes
Cele\C55C3.4
3 of 15
No
Yes
Cele\F22B3.8
3 of 15
No
Yes
Cele\F23C8.7
3 of 15
No
Yes
Cele\F57B9.8
3 of 15
No
Yes
Cele\kin-5
3 of 15
No
Yes
Cele\kin-6
3 of 15
No
Yes
Cele\kin-26
3 of 15
No
Yes
Cele\R05H5.4
3 of 15
No
Yes
Cele\R11E3.1
3 of 15
No
Yes
Cele\T06C10.3
3 of 15
No
Yes
Cele\T25B9.4
3 of 15
No
Yes
Cele\W01B6.5
3 of 15
No
Yes
Cele\Y116A8C.38
3 of 15
No
Yes
Cele\ZC581.7
3 of 15
No
Yes
Cele\C18H7.4
2 of 15
No
Yes
Cele\kin-31
2 of 15
No
Yes
Cele\W03F8.2
2 of 15
No
Yes
Cele\Y4C6A.1
2 of 15
No
Yes
Cele\Y43C5B.2
2 of 15
No
Yes
Cele\ZK593.9
2 of 15
No
Yes
Cele\C34F11.5
1 of 15
No
No
Cele\F01D4.3
1 of 15
No
Yes
Cele\M176.9
1 of 15
No
Yes
Cele\T08G5.2
1 of 15
No
Yes
Cele\T08G5.15
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (16)
Atha\AT2G19230
1 of 9
Yes
Yes
Atha\AT3G22750
1 of 9
Yes
No
Atha\AT3G50730
1 of 9
Yes
No
Atha\AT4G14780
1 of 9
Yes
No
Atha\AT5G01850
1 of 9
Yes
Yes
Atha\AT5G40540
1 of 9
Yes
Yes
Atha\AT5G47070
1 of 9
Yes
Yes
Atha\AT5G50000
1 of 9
Yes
No
Atha\AT5G50180
1 of 9
Yes
Yes
Atha\AT5G57610
1 of 9
Yes
Yes
Atha\AT5G66710
1 of 9
Yes
No
Atha\ATMRK1
1 of 9
Yes
No
Atha\ATN1
1 of 9
Yes
Yes
Atha\HT1
1 of 9
Yes
No
Atha\RKF1
1 of 9
Yes
Yes
Atha\VIK
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ppk1
1 of 12
Yes
Yes
Spom\shk1
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919018J )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010313
Drosophila simulans
Dsim\GD20803
Drosophila sechellia
Dsec\GM26266
Drosophila erecta
Dere\GG17381
Drosophila yakuba
Dyak\GE24784
Drosophila ananassae
Dana\GF17770
Drosophila pseudoobscura pseudoobscura
Dpse\GA21383
Drosophila persimilis
Dper\GL13676
Drosophila willistoni
Dwil\GK11727
Drosophila virilis
Dvir\GJ23577
Drosophila mojavensis
Dmoj\GI23604
Drosophila grimshawi
Dgri\GH18554
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500OQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020852
Musca domestica
House fly
Mdoa\17007298
Glossina morsitans
Tsetse fly
Gmor\GMOY002025
Mayetiola destructor
Hessian fly
Mdes\Mdes014172
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014512
Anopheles darlingi
American malaria mosquito
Adar\ADAC004454
Anopheles gambiae
Malaria mosquito
Agam\AGAP003651
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005385
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01NV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006417
Bombyx mori
Silkmoth
Bmor\BGIBMGA006416
Danaus plexippus
Monarch butterfly
Dple\DPOGS208227-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008372
Heliconius melpomene
Postman butterfly
Hmel\HMEL008373
Apis florea
Little honeybee
Aflo\2323814004
Apis mellifera
Western honey bee
Amel\GB44062
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21347
Bombus terrestris
Buff-tailed bumblebee
Bter\15215839
Linepithema humile
Argentine ant
Lhum\LH23611
Linepithema humile
Argentine ant
Lhum\LH23606
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002168
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009189
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02601
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00598
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00600
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00599
Tribolium castaneum
Red flour beetle
Tcas\TC031316
Pediculus humanus
Human body louse
Phum\PHUM259640
Rhodnius prolixus
Kissing bug
Rpro\RPRC008886
Rhodnius prolixus
Kissing bug
Rpro\RPRC010636
Cimex lectularius
Bed bug
Clec\CLEC003718
Cimex lectularius
Bed bug
Clec\CLEC003719
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001777
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03551
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01WQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008218
Ixodes scapularis
Black-legged tick
Isca\ISCW019316
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79159.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74587.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79156.1
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (11)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Abl
2 of 10
Ack
2 of 10
Ack-like
2 of 10
Btk29A
2 of 10
Csk
2 of 10
Shark
2 of 10
Src42A
2 of 10
Src64B
2 of 10
CG10702
1 of 10
Fak
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FER; FER tyrosine kinase
    12 of 15
    176942
        FES; FES proto-oncogene, tyrosine kinase
        11 of 15
        190030
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            FER - bsk
            anti tag coimmunoprecipitation, anti tag western blot
            (Li et al., 2019)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            FER
            suppressible
            puc
            (Murray et al., 2006)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Src42A
            enhanceable
            FER
            (Murray et al., 2006)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-48

            Cytogenetic map
            85D13-85D15
            Sequence location
            3R:9,367,603..9,394,546 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            85D13-85D15
            Limits computationally determined from genome sequence between P{lacW}l(3)L4092L4092 and P{PZ}ps10615&P{PZ}Ras85D06677
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            85D10-85D13
            (Paulson, 1996.3.2)
            85D10-85D13
            (determined by in situ hybridisation)
            (Katzen et al., 1991)
            Experimentally Determined Recombination Data
            Location

            3-48

            (FlyBase, 2016)

            3-46.1

            (Comeron et al., 2012)

            3-

            (Paulson, 1996.3.2)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (18)
            Genomic Clones (35)
            cDNA Clones (29)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Fps85D CG8874

              (Li, 1999.11)

              Source for identity of: FER Fps85D

              (Paulson et al., 1997)
              Source for database merge of
              Additional comments

              Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

              (Oates, 1997.11.10)
              Other Comments

              Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

              (Liu and Lehmann, 2008)

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              The 92kD and 45kD Fps85D protein isoforms can transform avian and rodent cells when expressed from retroviral vectors.

              (Paulson et al., 1997)

              Phylogenetic analysis of the PTK family.

              (Suga et al., 1997)

              Isolated using an avian v-fps gene fragment as a probe.

              (Katzen et al., 1991)

              Fps85D has been cloned, sequenced and its expression pattern analysed.

              (Katzen et al., 1991)
              Origin and Etymology
              Discoverer
              Etymology

              Named "FER" after the human ortholog.

              (FlyBase, 2009-)
              Identification
              External Crossreferences and Linkouts ( 72 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (24)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (93)