YA, fs(1)M12, EG:95B7.4 , fs(1)73, Young Arrest
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
708 (aa); 112 (kD observed); 91 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fs(1)Ya using the Feature Mapper tool.
fs(1)Ya protein is excluded from the nucleus in nurse cells and the oocyte and is found in the cytoplasm. The protein is found in nuclei in embryos. fs(1)Ya protein aquires the ability to enter nuclei upon egg activation and the switch correlates with the phosphorylation state of the protein.
fs(1)Ya protein is detected in mature eggs and embryos but not in adult males, females or ovaries. Its translation is independent of fertilization. fs(1)Ya protein persists throughout embryogenesis with its levels gradually decreasing to barely detectable in 24hr embryos. The level of protein does not decrease in unfertilized eggs for at least 8 hrs.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fs(1)Ya in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: fs(1)Ya CG2707
fs(1)Ya protein binds to chromatin directly and specifically. It also binds to His2B protein. This binding involves four chromatin-binding domains in fs(1)Ya, all of which bind to both DNA and His2B protein.
Recruitment of fs(1)Ya and Lam to the male pronucleus occurs prior to or during the early stages of pronuclear migration and this accompanies or requires reorganisation of the sperm nucleus. fs(1)Ya normally performs a function permissive for DNA replication.
fs(1)Ya protein is a maternally encoded nuclear envelope protein, a component of the nuclear lamina. Phenotypic analysis of mutant embryos suggest that the fs(1)Ya protein may be essential for the cleavage divisions as well as the first mitotic division.
Molecular and phenotypic analysis of mutant alleles suggests that fs(1)Ya function is required during and after egg maturation to facilitate proper chromatin condensation, rather than to allow a lamin-containing nuclear envelope to form.
Immunoelectron microscopy data and staining reveals fs(1)Ya is a functional component unique to embryonic nuclei but its presence does not depend solely on embryo-specific molecules. Results suggest fs(1)Ya protein is required but not sufficient for cleavage divisions to occur in embryos.
fs(1)Ya is a maternal-effect gene specifically involved in embryonic mitosis. fs(1)Ya gene function is required for the first embryonic mitosis, and may also be required for the normal progression of the subsequent embryonic mitoses.
Lack of the fs(1)Ya gene product causes homozygous females to arrest development at the syncytial cleavage stage.