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General Information
Symbol
Dmel\fs(1)Ya
Species
D. melanogaster
Name
female sterile (1) Young arrest
Annotation Symbol
CG2707
Feature Type
FlyBase ID
FBgn0000927
Gene Model Status
Stock Availability
Gene Snapshot
female sterile (1) Young arrest (fs(1)Ya) encodes a maternally-expressed protein that is required for mitotic phase initiation during early embryogenesis. It localizes in the nuclear lamina of the embryo, and binds DNA and the product of His2B. In developing oocytes the product of fs(1)Ya is cytoplasmic, but enters nuclei when it is dephosphorylated during egg activation. [Date last reviewed: 2019-09-26]
Also Known As
YA, fs(1)M12, EG:95B7.4 , Young Arrest, fs(1)73
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:2,724,286..2,726,577 [+]
Recombination map
1-1.5
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Molecular Function (GO)
    [Detailed GO annotations]
    Experimental Evidence
    Predictions / Assertions
    -
    Summaries
    Protein Function (UniProtKB)
    Cell cycle-dependent nuclear envelope component required for embryonic mitosis.
    (UniProt, P25028)
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    fs(1)Ya: female sterile of Young
    Homozygous females completely sterile; lay normal numbers of eggs. Eggs remain vacuolated after deposition. No evidence of syngamy (Zalokar, Audit, and Erk, 1975, Dev. Biol. 47: 419-32).
    Gene Model and Products
    Number of Transcripts
    1
    Number of Unique Polypeptides
    1

    Please see the GBrowse view of Dmel\fs(1)Ya or the JBrowse view of Dmel\fs(1)Ya for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Gene model reviewed during 5.50
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0070485
    2235
    696
    Additional Transcript Data and Comments
    Reported size (kB)
    2.4 (northern blot)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    FBpp0070463
    77.7
    696
    9.97
    Polypeptides with Identical Sequences

    There is only one protein coding transcript and one polypeptide associated with this gene

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    708 (aa); 112 (kD observed); 91 (kD predicted)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fs(1)Ya using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Gene Ontology (10 terms)
    Molecular Function (1 term)
    Terms Based on Experimental Evidence (1 term)
    CV Term
    Evidence
    References
    inferred from physical interaction with FLYBASE:Lam; FB:FBgn0002525
    Terms Based on Predictions or Assertions (0 terms)
    Biological Process (6 terms)
    Terms Based on Experimental Evidence (6 terms)
    CV Term
    Evidence
    References
    inferred from mutant phenotype
    inferred from mutant phenotype
    inferred from genetic interaction with FLYBASE:gnu; FB:FBgn0001120
    inferred from mutant phenotype
    inferred from mutant phenotype
    inferred from mutant phenotype
    Terms Based on Predictions or Assertions (0 terms)
    Cellular Component (3 terms)
    Terms Based on Experimental Evidence (3 terms)
    CV Term
    Evidence
    References
    inferred from direct assay
    colocalizes_with nuclear lamina
    inferred from direct assay
    inferred from physical interaction with FLYBASE:Lam; FB:FBgn0002525
    Terms Based on Predictions or Assertions (0 terms)
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    in situ
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    organism

    Comment: maternally deposited

    Comment: reference states 0-2 hr AEL

    Additional Descriptive Data
    fs(1)Ya is expressed in nurse cells and oocytes, and in 0-2 hour embryos.
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    immunolocalization
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    western blot
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Additional Descriptive Data
    fs(1)Ya protein is excluded from the nucleus in nurse cells and the oocyte and is found in the cytoplasm. The protein is found in nuclei in embryos. fs(1)Ya protein aquires the ability to enter nuclei upon egg activation and the switch correlates with the phosphorylation state of the protein.
    fs(1)Ya protein is detected in mature eggs and embryos but not in adult males, females or ovaries. Its translation is independent of fertilization. fs(1)Ya protein persists throughout embryogenesis with its levels gradually decreasing to barely detectable in 24hr embryos. The level of protein does not decrease in unfertilized eggs for at least 8 hrs.
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    inferred from direct assay
    colocalizes_with nuclear lamina
    inferred from direct assay
    inferred from physical interaction with FLYBASE:Lam; FB:FBgn0002525
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\fs(1)Ya in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 11 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 34 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of fs(1)Ya
    Transgenic constructs containing regulatory region of fs(1)Ya
    Deletions and Duplications ( 14 )
    Phenotypes
    Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905LM )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila melanogaster
    fruit fly
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila sechellia
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501RX )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Glossina morsitans
    Tsetse fly
    Mayetiola destructor
    Hessian fly
    Aedes aegypti
    Yellow fever mosquito
    Anopheles darlingi
    American malaria mosquito
    Anopheles gambiae
    Malaria mosquito
    Culex quinquefasciatus
    Southern house mosquito
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v7.1)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser

      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-1.5
      Cytogenetic map
      Sequence location
      X:2,724,286..2,726,577 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      3B3-3B3
      Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      3B3-3B4
      (determined by in situ hybridisation)
      Experimentally Determined Recombination Data
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (6)
      Genomic Clones (14)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (19)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: fs(1)Ya CG2707
        Source for database merge of
        Additional comments
        Other Comments
        fs(1)Ya protein binds to chromatin directly and specifically. It also binds to His2B protein. This binding involves four chromatin-binding domains in fs(1)Ya, all of which bind to both DNA and His2B protein.
        The RpLP0 containing 20S cytoplasmic complex may retain hyperphosphorylated ovarian fs(1)Ya in the cytoplasm.
        The ability of fs(1)Ya gene product to enter nuclei is modulated during development. The phosphorylation state of T443 is implicated in the nuclear entry of fs(1)Ya.
        Lam protein interacts with both Ote and fs(1)Ya in a yeast two-hybrid system.
        Recruitment of fs(1)Ya and Lam to the male pronucleus occurs prior to or during the early stages of pronuclear migration and this accompanies or requires reorganisation of the sperm nucleus. fs(1)Ya normally performs a function permissive for DNA replication.
        fs(1)Ya protein is capable of associating with decondensed chromatin.
        fs(1)Ya protein is a maternally encoded nuclear envelope protein, a component of the nuclear lamina. Phenotypic analysis of mutant embryos suggest that the fs(1)Ya protein may be essential for the cleavage divisions as well as the first mitotic division.
        The fs(1)Ya protein might interact with itself, either directly or indirectly.
        Molecular and phenotypic analysis of mutant alleles suggests that fs(1)Ya function is required during and after egg maturation to facilitate proper chromatin condensation, rather than to allow a lamin-containing nuclear envelope to form.
        In a yeast two hybrid system no interactions between lamin or otefin and the fs(1)Ya product, nor between the fs(1)Ya product and itself were detected.
        Immunoelectron microscopy data and staining reveals fs(1)Ya is a functional component unique to embryonic nuclei but its presence does not depend solely on embryo-specific molecules. Results suggest fs(1)Ya protein is required but not sufficient for cleavage divisions to occur in embryos.
        fs(1)Ya is a maternal-effect gene specifically involved in embryonic mitosis. fs(1)Ya gene function is required for the first embryonic mitosis, and may also be required for the normal progression of the subsequent embryonic mitoses.
        fs(1)Ya is required for the fusion of the apposed sperm and egg pronuclei (syngamy) following fertilization. It is tightly linked to fs(1)Yb.
        Lack of the fs(1)Ya gene product causes homozygous females to arrest development at the syncytial cleavage stage.
        fs(1)Ya gene product is required for nuclear divisions.
        Origin and Etymology
        Discoverer
        Young.
        Etymology
        Identification
        External Crossreferences and Linkouts ( 32 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (13)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (81)