tudor domain RNA helicase, post-transcriptional gene regulation - regulates transposon silencing via the piRNA pathway - component of the Yb body, a site for Piwi-associated RNA biogenesis, regulates Piwi transport to the nucleus
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
1042 (aa); 117 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fs(1)Yb using the Feature Mapper tool.
fs(1)Yb transcripts are detected in all stages tested on northern blots (third instar larvae, pupae, and adults). In females, they are detected weakly in third instar larvae, are more abundant in pupae, and decrease in adults. In males, they are highest in third instar larvae and decrease in the pupal and adult stages. fs(1)Yb transcripts are detected by in situ hybridization in ovarioles in the terminal filament and the epithelial sheath that envelopes the terminal filament.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fs(1)Yb in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
fs(1)Yb is required for both germline stem cell and somatic stem cell divisions in the ovary.
fs(1)Yb is required in the soma for ovary follicle cell differentiation and to support later stages of egg maturation. Mutations at fs(1)Yb show genetic interactions with the N group of neurogenic genes.
fs(1)Yb gene product affects the asymmetric division of the female germline stem cell (GSC).