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Gene Dmel\fs(1)Yb

General Information
Symbol	Dmel\fs(1)Yb	Species	D. melanogaster
Name	female sterile (1) Yb	Annotation symbol	CG2706
Feature type	protein_coding_gene	FlyBase ID	FBgn0000928
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Yb, EG:95B7.8
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.8
Cytogenetic map	3B3-3B3	Sequence location	X:2,614,501..2,618,191 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene female sterile (1) Yb is referred to in FlyBase by the symbol Dmel\fs(1)Yb (CG2706, FBgn0000928). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; oogenesis; germ cell development; germ-line stem cell division. 33 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; organ system; anatomical structure; ovariole; cytoplasmic part; acellular anatomical structure; organelle; portion of tissue; stem cell; intracellular non-membrane-bounded organelle; epithelial cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Tudor domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1624187_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of fs(1)Yb. Gene sequence location is X:2614501..2618191.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fs(1)Yb Homozygous females semisterile; lay reduced numbers of eggs, most of which remain vacuolated after deposition; a few develop into normal-appearing adults. Mutation without effect on males.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3B3-3B3   Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3C1-3C1     (King, 1999.4.8) 3B1-3B1   Determined by deficiency mapping (details unspecified).   (Swan et al., 2001)
Experimentally Determined Recombination Data
Location	1-1.8
Left of (cM)	fs(1)Ya dwg
Right of (cM)	l(1)3Bd
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fs(1)Yb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 DGC clone appears problematic (AT22217): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fs(1)Yb-RA FBtr0070484  NM_058146   3502   1042
Additional Transcript Data & Comments
Reported size (kB)	4.1 (northern blot) (King and Lin, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fs(1)Yb-PA   FBpp0070462   117.5   1042   7.02     NP_477494   AAF45815
Additional Polypeptide Data & Comments
Reported size (kDa)	1042 (aa); 117 (kD predicted) (King and Lin, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) Tudor domain (IPR002999)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45815   AF141673 AAD32687   AY113291 AAM29296   BF487420   BG639997
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W4W2 Q8MZ98 Q9UB20
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference larval stage & pupal stage & adult stage     (King and Lin, 1999) adult stage & oogenesis   ovariole   (King and Lin, 1999) epithelial sheath   (King and Lin, 1999) terminal filament   (King and Lin, 1999)
Additional Descriptive Data
	fs(1)Yb transcripts are detected in all stages tested on northern blots (third instar larvae, pupae, and adults). In females, they are detected weakly in third instar larvae, are more abundant in pupae, and decrease in adults. In males, they are highest in third instar larvae and decrease in the pupal and adult stages. fs(1)Yb transcripts are detected by in situ hybridization in ovarioles in the terminal filament and the epithelial sheath that envelopes the terminal filament. (King and Lin, 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Yb body inferred from direct assay (Szakmary et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.475 Larval Midgut    13.6 Larval Hindgut    7.6 Larval Malpighian Tubules    3.9 Larval Fat Body    22.6 Larval Salivary Gland    5.8 Larval Trachea    4.6 Larval Carcass    4.775 Adult Head    9.1 Adult Eye    7.925 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    4.9 Adult Midgut    6.9 Adult Hindgut    4.7 Adult Malpighian Tubules    4.5 Adult Fat Body    6.9 Adult Salivary Gland    4.6 Adult Heart    3.85 Adult VirginFemale Spermatheca    6.1 Adult InseminatedFemale Spermatheca    6.3 Adult Ovary    8.7 Adult Testis    26.3 Adult Male Accessory Gland    4.4 Adult Carcass    8.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    9.1   NA  Eye    7.925   NA  Brain    2.7   4.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.6   NA  Crop    4.9   no informative data  Midgut    6.9   7.6  Hindgut    4.7   3.9  Malpighian Tubules    4.5   no informative data  Fat Body    6.9   5.8  Salivary Gland    4.6   NA  Heart    3.85   4.6  Trachea    NA   NA  VirginFemale Spermatheca    6.1   NA  InseminatedFemale Spermatheca    6.3   NA  Ovary    8.7   NA  Testis    26.3   NA  Male Accessory Gland    4.4   4.775  Carcass    8.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1    32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS    35 ovary OSC    44 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4  (28) embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1  (32) embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS  (35) ovary OSC  (44) ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1    32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS    35 ovary OSC    44 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1    32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS    35 ovary OSC    44 ovary OSS    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1    32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS    35 ovary OSC    44 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4  28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1  32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS  (35) ovary OSC  (44) ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1    32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS    35 ovary OSC    44 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    28 embryonic 1182-4H    14 embryonic GM2    13 embryonic Kc167    8 embryonic S1    32 embryonic S3    14 leg disc CME L1    18 wing disc CME-W2    18 wing disc ML-DmD8    8 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    20 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    8 ovary fGS/OSS    35 ovary OSC    44 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000928 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2706-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect | recessive fs(1)Yb1 viable fs(1)Yb72 viable, with Scer\GAL4pnr-MD237 fs(1)YbGD9813 Sterility Allele female fertile fs(1)Ybt8.1 female semi-sterile | recessive fs(1)Yb1 female sterile fs(1)Yb72 female sterile | recessive fs(1)YbM104-1 fs(1)YbM104-2 fs(1)YbM104-3 male fertile fs(1)Yb72 Other Phenotypes Allele wild-type fs(1)Ybhs.T:Zzzz\His6,T:Zzzz\FLAG fs(1)Ybt8.1 Phenotype manifest in Allele basal stalk fs(1)YbM104-1 fs(1)YbM104-3 dorsal appendage fs(1)YbM104-1 fs(1)YbM104-3 egg fs(1)YbM104-1 fs(1)YbM104-3 egg | maternal effect fs(1)Yb1 egg chamber fs(1)Yb1 fs(1)YbM104-1 fs(1)YbM104-3 female germline stem cell | supernumerary, with Scer\GAL4hs.PB fs(1)YbScer\UAS.cKa follicle cell fs(1)Yb1 fs(1)YbM104-1 fs(1)YbM104-3 germarium fs(1)Yb1 fs(1)Yb72 fs(1)YbM104-1 fs(1)YbM104-3 germline cyst fs(1)YbM104-1 germline stem cell fs(1)Yb1 fs(1)YbM104-3 interfollicle cell | supernumerary, with Scer\GAL4hs.PB fs(1)YbScer\UAS.cKa nurse cell spectrosome, with Scer\GAL4hs.PB fs(1)YbScer\UAS.cKa ovariole fs(1)Yb1 fs(1)YbdsRNA.cDa ovary fs(1)YbM104-1 fs(1)YbM104-2 fs(1)YbM104-3 spectrosome fs(1)Yb72
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of fs(1)Yb Class Mutagen Stocks Known lesion fs(1)YbM104-2 loss of function allele ethyl methanesulfonate 2 -- fs(1)YbM104-3 loss of function allele ethyl methanesulfonate 2 Yes fs(1)Yb72 ethyl methanesulfonate 1 Yes fs(1)Yb1 ethyl methanesulfonate 0 Yes fs(1)Yb2 ethyl methanesulfonate 0 -- fs(1)Yb3 ethyl methanesulfonate 0 -- fs(1)YbM104-1 loss of function allele ethyl methanesulfonate 0 Yes fs(1)Ybunspecified 0 --
Alleles Carried on Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fs(1)Yb Class Mutagen Stocks Known lesion fs(1)YbGD9813 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes fs(1)YbGL00053 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fs(1)YbGL00204 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fs(1)Yb5x.T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes fs(1)YbAS10.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - deletion 0 Yes fs(1)YbAS11.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - deletion 0 Yes fs(1)YbAS5.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - deletion 0 Yes fs(1)YbAS6.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct 0 Yes fs(1)YbAS7.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - deletion 0 Yes fs(1)YbAS8.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - deletion 0 Yes fs(1)YbAS9.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - deletion 0 Yes fs(1)YbdsRNA.cDa in vitro construct - RNAi 0 Yes fs(1)YbdsRNA.shRNA.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes fs(1)Ybhs.T:Zzzz\His6,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fs(1)YbKK105851 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes fs(1)YbScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes fs(1)Ybt1.8 in vitro construct - genomic fragment 0 Yes fs(1)Ybt3.9 in vitro construct - genomic fragment 0 Yes fs(1)Ybt4.6 in vitro construct - genomic fragment 0 Yes fs(1)Ybt6.4 in vitro construct - genomic fragment 0 Yes fs(1)Ybt7.2 in vitro construct - genomic fragment 0 Yes fs(1)Ybt7.7 in vitro construct - genomic fragment 0 Yes fs(1)Ybt8.1 in vitro construct - genomic fragment 0 Yes fs(1)YbT:Avic\GFP in vitro construct - coding region fusion 0 Yes fs(1)YbT:Zzzz\His6,T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)64c4 (Thierry-Mieg, 1982) Df(1)w258-11 (Thierry-Mieg, 1982) Df(1)w258-42 (Thierry-Mieg, 1982) Df(1)w258-45 (Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)w-rJ1 (Thierry-Mieg, 1982) Df(1)X12 (Thierry-Mieg, 1982)
Not disrupted in	Df(1)62g18 (Thierry-Mieg, 1982) Df(1)64f1 (Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)64j4 (Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)65j26 (Thierry-Mieg, 1982) Df(1)K95 (Thierry-Mieg, 1982) Df(1)N-8 (Lin and Wolfner, 1989) Df(1)TEM7 (Thierry-Mieg, 1982) Df(1)w55j (Lin and Wolfner, 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9813} NA P{KK105851} NA P{TRiP.GL00053} NA P{TRiP.GL00204} NA P{UASp-fs(1)Yb.shRNA} NA P{UAS-Yb.K} NA heat-shock construct P{hs-Yb.His6,FLAG} NA characterization construct P{fs(1)Ya+t7.2} NA P{fs(1)Ya+t7.7} NA P{fs(1)Ya+t8.1} NA P{fs(1)Yat3.9} NA P{fs(1)Yb.GFP} NA P{fs(1)Ybt1.8} NA P{fs(1)Ybt4.6} NA P{fs(1)Ybt6.4} NA P{Yb.5xFLAG} NA P{Yb.His6,FLAG.AS5} NA P{Yb.His6,FLAG.AS6} NA P{Yb.His6,FLAG.AS7} NA P{Yb.His6,FLAG.AS8} NA P{Yb.His6,FLAG.AS9} NA P{Yb.His6,FLAG.AS10} NA P{Yb.His6,FLAG.AS11} NA P{Yb.His6,FLAG} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
germ cell development inferred from mutant phenotype (King et al., 2001) germ-line stem cell division inferred from mutant phenotype (King and Lin, 1999) germ-line stem cell maintenance inferred from mutant phenotype (King and Lin, 1999) oogenesis inferred from mutant phenotype (King and Lin, 1999)
Cellular Component
CV term Evidence References
Yb body inferred from direct assay (Szakmary et al., 2009)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
germ-line stem cell division traceable author statement (Lin, 2002, Deng and Lin, 2001) ovarian follicle cell stalk formation traceable author statement (Dobens and Raftery, 2000) somatic stem cell division traceable author statement (Lin, 2002)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity (King and Lin, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
fs(1)Yb - armi western blot, anti bait coimmunoprecipitation (Handler et al., 2011) fs(1)Yb - vret western blot, anti bait coimmunoprecipitation (Handler et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fs(1)Yb allele Gene References fs(1)Yb1 hh (King et al., 2001) fs(1)Yb72 hh (King et al., 2001) fs(1)YbM104-3 ptc (King et al., 2001) unspecified da (Johnson et al., 1995) Dl (Johnson et al., 1995) dl (Johnson et al., 1995) mam (Johnson et al., 1995) N (Johnson et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57793 DroID - A comprehensive database of gene and protein interactions. • FBgn0000928 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31262
Orthologs
OrthoDB Orthologs (11) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WM5DH Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6WM5DH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\fs(1)Yb     Drosophila sechellia   Dsec\GM11189     Drosophila sechellia   Dsec\GM19244 Y   Drosophila erecta   Dere\GG18624 Y   Drosophila yakuba   Dyak\GE16277 Y   Drosophila ananassae   Dana\GF22451 Y   Drosophila willistoni   Dwil\GK24909 Y   Drosophila willistoni   Dwil\GK14800     Drosophila virilis   Dvir\GJ18700 Y   Drosophila mojavensis   Dmoj\GI15873 Y   Drosophila grimshawi   Dgri\GH12780 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM19244 Drosophila erecta Dere\GG18624 Drosophila yakuba Dyak\GE16277 Drosophila ananassae Dana\GF22451 Drosophila willistoni Dwil\GK24909 Drosophila virilis Dvir\GJ18700 Drosophila mojavensis Dmoj\GI15873 Drosophila grimshawi Dgri\GH12780
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	35181 y1 sc* v1; P{TRiP.GL00053}attP2 35301 y1 sc* v1; P{TRiP.GL00204}attP2 7388 y1 w1118 fs(1)Yb72 P{neoFRT}19A/FM6 4555 C(1;Y)6, y1 fs(1)YbM104-2 cv1 v1/FM7c 4617 y1 fs(1)YbM104-3 cv1 v1 f1/FM0
Kyoto	107794 C(1;Y)6, y1 fs(1)YbM104-2 cv1 v1/FM7c 107824 y1 fs(1)YbM104-3 cv1 v1 f1/FM0
VDRC	v25435 w1118; P{GD9813}v25435 v25437 w1118; P{GD9813}v25437/TM3
Genomic Clones ( 1 )
	BACR30B01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT22217
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	SD10010
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000928 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31262
Antibody Information
	polyclonal (Szakmary et al., 2009)
Other Information
Discoverer
	Young.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: EG:95B7.8 CG2706 (Deng, 1999.11)
Source for database merge of	Source for merge of: fs(1)Yb EG:95B7.8 (FlyBase, 1996-)
Additional comments	Source for merge of fs(1)Yb EG:95B7.8 was sequence comparison (date:991228). (FlyBase, 1996-)
Other Comments
	fs(1)Yb is required for both germline stem cell and somatic stem cell divisions in the ovary. (King et al., 2001) fs(1)Yb is required for the maintenance of germline stem cells during oogenesis. The function of fs(1)Yb is soma-dependent. (King and Lin, 1999) fs(1)Yb is required in the soma for ovary follicle cell differentiation and to support later stages of egg maturation. Mutations at fs(1)Yb show genetic interactions with the N group of neurogenic genes. (Johnson et al., 1995) Mitotic germline recombination demonstrates that fs(1)Yb is soma- dependent. (Johnson et al., 1992) fs(1)Yb gene product affects the asymmetric division of the female germline stem cell (GSC). (Lin and Spradling, 1992) fs(1)Yb is required for oogenesis and embryogenesis. It is tightly linked to fs(1)Ya. (Lin and Wolfner, 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058146 RefSeq (Proteins) • NP_477494 DDBJ / EMBL / GenBank • AAD32687 AAF45815 AAM29296 AF141673 AL021728 AY113291 BF487420 Entrez Gene - A searchable database of RefSeq genes. • 31262 UniProtKB/TrEMBL • Q8MZ98 Q9UB20 Q9W4W2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) Tudor domain (IPR002999)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57793 DroID - A comprehensive database of gene and protein interactions. • FBgn0000928 DRSC - Results from RNAi screens. • FBgn0000928 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000928 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2706-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000928 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31262 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31262 modMine - Data generated by the modENCODE project. • FBgn0000928
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG2706 (Benos, 2000.12.13, Juhola et al., 2000, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) EG:95B7.8 (Benos et al., 2001, Benos, 2000.12.13, ) fs(1)M104   fs(1)Yb (Judd, 1998) fs(1)Yb (Gonzalez-Reyes, 2003, Olivieri et al., 2010, Janic et al., 2010, Handler et al., 2011) nov   Yb (Szakmary et al., 2005, Gilboa and Lehmann, 2004, Deng and Lin, 2001, Lin, 2002, Szakmary and Lin, 2002, King et al., 2001, Nystul and Spradling, 2006, Qi et al., 2011, Smulders-Srinivasan et al., 2010, Xie et al., 2005, Szakmary et al., 2009, Saito et al., 2010, Handler et al., 2011, Olivieri et al., 2012) YB (Lin, 2008)
Name Synonym	female sterile(1)M104   female sterile (1) Yb   female sterile(1)Yb (Janic et al., 2010) no ovaries
Secondary FlyBase IDs
	FBgn0000897 FBgn0024974
References ( 63 )
Generate a list of	All references relating to this gene ( 63 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 15 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 11 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 )
Recent research papers ( 3 )
	Olivieri et al., 2012, Mol. Cell 47(6): 954--969 The Cochaperone Shutdown Defines a Group of Biogenesis Factors Essential for All piRNA Populations in Drosophila. [FBrf0219572] Handler et al., 2011, EMBO J. 30(19): 3977--3993 A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. [FBrf0216344] Qi et al., 2011, J. Biol. Chem. 286(5): 3789--3797 The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells. [FBrf0212916] Show all research papers ...
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	All reviews listed in FlyBase were published before 2011 Show reviews ...