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Gene Dmel\dup

General Information
Symbol	Dmel\dup	Species	D. melanogaster
Name	double parked	Annotation symbol	CG8171
Feature type	protein_coding_gene	FlyBase ID	FBgn0000996
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	CDT1, l(2)k03308, DUP/CDT1, fs(2)PA77, l(2)51Ec, CDT1/DUP, 19k
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51F11-51F11	Sequence location	2R:11,264,124..11,268,493 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene double parked is referred to in FlyBase by the symbol Dmel\dup (CG8171, FBgn0000996). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: chorion-containing eggshell formation; DNA replication checkpoint; mitotic sister chromatid separation; cytokinesis; DNA replication; antimicrobial humoral response; centrosome duplication; DNA endoreduplication. 21 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; mitotic cell cycle; metaphase plate; follicle cell; subperineurial glial cell; imaginal disc; S phase; cycle 16 embryo; mitotic metaphase. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: CDT1 Geminin-binding domain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624994_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dup. Gene sequence location is 2R:11264124..11268493.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51F11-51F11   Limits computationally determined from genome sequence between P{PZ}scb01288 and P{lacW}dupk03308
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51F11-51F12   (determined by in situ hybridisation)   (Spradling et al., 1999) 51F11-51F12     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dup for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dup-RA FBtr0087387  NM_080139   3138   743 dup-RB FBtr0339999     2764   743
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dup-PA   FBpp0086519   83.5   743   10.46     NP_524878   AAF58141 dup-PB   FBpp0309018   83.5   743   10.46
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CDT1 Geminin-binding domain-like (IPR014939)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201680   AA201828   AA201960   AA202804   AA263659   AA263733   AA390385   AA391186   AA392132   AA438439   AA438582   AA439893   AA440311   AA539011   AA539703   AA540370   AA735599   AA816333   AA817065   AA817194   AA940895   AA949036   AA949644   AA950101   AA951295   AA979115   AA979253   AE013599 AAF58141   AF279146 AAF99080   AI455239   AI456177   AI512747   AI515317   AI515518   AI516503   AI517989   AI518051   AI518585   AI518911   AI519301   AI519474   AI519880   AI520434   AQ034142   AQ074067   AX482663   AY118555 AAM49924   AY231682   BI163315   BI164345   BI168167   BI227677   BI231839   BI234251   BI235962   BI237208   BI237567   BI238962   BI240837   BI241256   BI241519   BI241844   BI242759   BI356361   BI362096   BI366508   BI370186   BI370723   BI372468   BI372892   BI374872   BI483813   BI578529   BI579416   BI581504   BI604709   BI633786   BQ103192   CO153134   CO186424   CO266409   CO273203   CO279163   CO288523   CO292427   CO298959   CO302288   CO316260   CO317354   CO318145   CO323414   CO330174   CZ470214   CZ470250   EC051429   EC051882   EC051903   EC053424   EC054412   EC054417   EC056063   EC056519   EC060437   EC061224   EC070093   EC074611   EC076957   EC077948   EC078220   EC078914   EC079807   EC086563   EC203163   EC209616   EC221456   EC221936   EC229221   EC229222   EC245929   EC249929   EC266318   ES695872   ES695875   EV590565   GH760585   GH783996   GH786473   GH819305   GH835139   GH862265   GH864262   GH867189   GH876080   GH882124   GH883643   GH901450   GH914492   GH919838
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JVY2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Whittaker et al., 2000) nuclear origin of replication recognition complex inferred from direct assay (Whittaker et al., 2000) nucleus inferred from direct assay (Whittaker et al., 2000) replication fork inferred from direct assay (Claycomb et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  (1105.8) Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  (1105.8) Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  (1105.8) Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland    39.6 Adult Heart    12.9 Adult VirginFemale Spermatheca    15.7 Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21.3   NA  Eye    11.8   NA  Brain    18.4   376.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    18.8   NA  Crop    25.3   40.7  Midgut    36.5   56.4  Hindgut    17.3   26.8  Malpighian Tubules    28.3   27.9  Fat Body    25.2   200.8  Salivary Gland    no informative data   NA  Heart    12.9   85.025  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    16.9   NA  Ovary    1105.8   NA  Testis    40.4   NA  Male Accessory Gland    26.2   100.1  Carcass    39 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    176 ovary, mated 4-day female    185 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (176) ovary, mated 4-day female  (185) testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (176) ovary, mated 4-day female  (185) testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    176 ovary, mated 4-day female    185 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    176 ovary, mated 4-day female    185 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (176) ovary, mated 4-day female  (185) testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (176) ovary, mated 4-day female  (185) testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    26 central nervous system, pupae P8    3 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    10 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    14 carcass, 1-day adult    4 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    176 ovary, mated 4-day female    185 testis, mated 4-day male    5 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    157 embryo 02-04hr    141 embryo 04-06hr    167 embryo 06-08hr    142 embryo 08-10hr    97 embryo 10-12hr    53 embryo 12-14hr    45 embryo 14-16hr    49 embryo 16-18hr    40 embryo 18-20hr    21 embryo 20-22hr    86 embryo 22-24hr    66 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    29 adult female 05day    71 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (157) embryo 02-04hr  (141) embryo 04-06hr  (167) embryo 06-08hr  (142) embryo 08-10hr  (97) embryo 10-12hr  (53) embryo 12-14hr  (45) embryo 14-16hr  (49) embryo 16-18hr  (40) embryo 18-20hr    21 embryo 20-22hr  (86) embryo 22-24hr  (66) larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day  (29) adult female 05day  (71) adult female 30day  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (157) embryo 02-04hr  (141) embryo 04-06hr  (167) embryo 06-08hr  (142) embryo 08-10hr    97 embryo 10-12hr    53 embryo 12-14hr    45 embryo 14-16hr    49 embryo 16-18hr    40 embryo 18-20hr    21 embryo 20-22hr    86 embryo 22-24hr    66 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    29 adult female 05day    71 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    157 embryo 02-04hr    141 embryo 04-06hr    167 embryo 06-08hr    142 embryo 08-10hr    97 embryo 10-12hr    53 embryo 12-14hr    45 embryo 14-16hr    49 embryo 16-18hr    40 embryo 18-20hr    21 embryo 20-22hr    86 embryo 22-24hr    66 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    29 adult female 05day    71 adult female 30day    75 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    157 embryo 02-04hr    141 embryo 04-06hr    167 embryo 06-08hr    142 embryo 08-10hr    97 embryo 10-12hr    53 embryo 12-14hr    45 embryo 14-16hr    49 embryo 16-18hr    40 embryo 18-20hr    21 embryo 20-22hr    86 embryo 22-24hr    66 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    29 adult female 05day    71 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (157) embryo 02-04hr  (141) embryo 04-06hr  (167) embryo 06-08hr  (142) embryo 08-10hr  (97) embryo 10-12hr  (53) embryo 12-14hr  (45) embryo 14-16hr  (49) embryo 16-18hr  (40) embryo 18-20hr    21 embryo 20-22hr  (86) embryo 22-24hr  (66) larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day  29 adult female 05day  (71) adult female 30day  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (157) embryo 02-04hr  141 embryo 04-06hr  (167) embryo 06-08hr  142 embryo 08-10hr    97 embryo 10-12hr    53 embryo 12-14hr    45 embryo 14-16hr    49 embryo 16-18hr    40 embryo 18-20hr    21 embryo 20-22hr    86 embryo 22-24hr    66 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    29 adult female 05day    71 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    157 embryo 02-04hr    141 embryo 04-06hr    167 embryo 06-08hr    142 embryo 08-10hr    97 embryo 10-12hr    53 embryo 12-14hr    45 embryo 14-16hr    49 embryo 16-18hr    40 embryo 18-20hr    21 embryo 20-22hr    86 embryo 22-24hr    66 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    8 white prepupae new    8 white prepupae 12hr    12 white prepupae 24hr    9 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    29 adult female 05day    71 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    99 embryonic S1    29 embryonic S3    39 leg disc CME L1    50 wing disc CME-W2    32 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    91 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    204 ovary OSC    66 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (76) Schneider line 2 Sg4  (48) embryonic 1182-4H  (31) embryonic GM2  (30) embryonic Kc167  (99) embryonic S1  (29) embryonic S3  (39) leg disc CME L1  (50) wing disc CME-W2  (32) wing disc ML-DmD8  (35) wing disc ML-DmD9  (30) wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (37) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (91) CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS  (204) ovary OSC  (66) ovary OSS  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    99 embryonic S1    29 embryonic S3    39 leg disc CME L1    50 wing disc CME-W2    32 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    91 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS  (204) ovary OSC    66 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    99 embryonic S1    29 embryonic S3    39 leg disc CME L1    50 wing disc CME-W2    32 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    91 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    204 ovary OSC    66 ovary OSS    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    99 embryonic S1    29 embryonic S3    39 leg disc CME L1    50 wing disc CME-W2    32 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    91 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    204 ovary OSC    66 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (76) Schneider line 2 Sg4  (48) embryonic 1182-4H  31 embryonic GM2  30 embryonic Kc167  (99) embryonic S1  29 embryonic S3  (39) leg disc CME L1  (50) wing disc CME-W2  32 wing disc ML-DmD8  (35) wing disc ML-DmD9  30 wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (37) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (91) CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS  (204) ovary OSC  (66) ovary OSS  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    99 embryonic S1    29 embryonic S3    39 leg disc CME L1    50 wing disc CME-W2    32 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    91 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS  (204) ovary OSC    66 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    31 embryonic GM2    30 embryonic Kc167    99 embryonic S1    29 embryonic S3    39 leg disc CME L1    50 wing disc CME-W2    32 wing disc ML-DmD8    35 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    91 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    204 ovary OSC    66 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    143 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    81 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    114 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    120 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    66 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (28) cold shock, 4-day adult    19 heat shock, 4-day adult  (50) Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  (54) Cadmium 100 mM 48 hrs, 4-day adult  (143) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (81) Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (114) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (120) Caffeine 25 mg/ml 48 hrs, 4-day adult  (41) Paraquat 5 mM 48 hrs, 4-day adult  (98) Paraquat 10 mM 48 hrs, 4-day adult  (66) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult  (143) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    81 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3  (114) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (120) Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    66 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    143 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    81 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    114 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    120 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    66 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    143 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    81 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    114 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    120 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    66 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  28 cold shock, 4-day adult    19 heat shock, 4-day adult  (50) Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  (54) Cadmium 100 mM 48 hrs, 4-day adult  (143) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (81) Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (114) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (120) Caffeine 25 mg/ml 48 hrs, 4-day adult  (41) Paraquat 5 mM 48 hrs, 4-day adult  (98) Paraquat 10 mM 48 hrs, 4-day adult  (66) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult  143 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    81 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3  114 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  120 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    66 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    19 heat shock, 4-day adult    50 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    54 Cadmium 100 mM 48 hrs, 4-day adult    143 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    81 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    114 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    120 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    98 Paraquat 10 mM 48 hrs, 4-day adult    66 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000996 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8171-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dupCB04090 dupl5 lethal, with Scer\GAL4pnr-MD237 dupGD13203 lethal | embryonic stage | recessive dupa1 dupa2 dupa3 dupa4 lethal | recessive dupk03308 Sterility Allele female sterile dupPA77 Other Phenotypes Allele cytokinesis defective dupa1 decreased cell size, with Scer\GAL4moody.PS dupGD13203 decreased cell size, with Scer\GAL4Mz97 dupGD13203 endomitotic cell cycle defective, with Scer\GAL4moody.PS dupGD13203 endomitotic cell cycle defective, with Scer\GAL4Mz97 dupGD13203 increased cell death dup10(A).hsp70.T:Hsap\MYC dupdsRNA.cRa duphsp70.T:Hsap\MYC mitotic cell cycle defective dupa1 dupa3 dupPA77 mitotic cell cycle defective (with dupa1) dupPA77 mitotic cell cycle defective (with dupPA77) dupa1 mitotic cell cycle defective | maternal effect dupunspecified Phenotype manifest in Allele cycle 16 embryo dupa1 dupa3 eye disc duphsp70.T:Hsap\MYC follicle cell dup10(A).hsp70.T:Hsap\MYC dupC.hsp70.T:Hsap\MYC duphsp70.T:Hsap\MYC imaginal disc dup10(A).hsp70.T:Hsap\MYC duphsp70.T:Hsap\MYC dupk03308 kinetochore | maternal effect dupunspecified metaphase plate dupa1 mitosis & nuclear chromosome dupa1 dupa3 mitotic cell cycle dupPA77 dupa1 dupa3 mitotic cell cycle (with dupa1) dupPA77 mitotic cell cycle (with dupPA77) dupa1 mitotic metaphase dupa1 dupa3 S phase dupa1 dupunspecified S phase | embryonic cycle 16 dupa1 subperineurial glial cell, with Scer\GAL4moody.PS dupGD13203 subperineurial glial cell, with Scer\GAL4Mz97 dupGD13203
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of dup Class Mutagen Stocks Known lesion dupk03308 P-element activity 4 Yes dupPA77 ethyl methanesulfonate 2 Yes dupa1 1 Yes dupa3 1 Yes dupa2 0 -- dupA3 0 -- dupa4 0 -- dupc05735 piggyBac transposase 0 -- dupc05782 piggyBac transposase 0 -- dupCB04090 P-element activity 0 Yes dupEP2060 P-element activity 0 -- dupl5 gamma ray 0 -- dupunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dup Class Mutagen Stocks Known lesion dupGD13203 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dupJF03241 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dup10(A).hsp70.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes dupC.hsp70.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dupdsRNA.cRa in vitro construct - RNAi 0 Yes duphsp70.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dupN.hsp70.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes dupNIG.8171R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC346 (Christensen and Cook, 2007.10.29) Df(2R)Exel9015 (Ryder, 2004.4.26) Df(2R)Jp1 (Spradling et al., 1999, Sekelsky et al., 2000, Whittaker et al., 2000, BDGP Project Members, 1994-1999) Df(2R)l4 (Underwood et al., 1990) Df(2R)l13 (Underwood et al., 1990, Smith et al., 1993) Df(2R)XTE-11 (Underwood et al., 1990) Df(2R)XTE-18 (Sekelsky et al., 2000, Underwood et al., 1990, Schupbach and Wieschaus, 1991) Df(2R)XTED4 (Underwood et al., 1990)
Not disrupted in	Df(2R)Jp4 (Spradling et al., 1999, Sekelsky et al., 2000, BDGP Project Members, 1994-1999) Df(2R)Jp5 (BDGP Project Members, 1994-1999) Df(2R)knSA3 (Sekelsky et al., 2000) Df(2R)l4 (Underwood et al., 1990) Df(2R)XTE-58 (Underwood et al., 1990) Df(2R)XTED1 (Underwood et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13203} NA P{NIG.8171R} NA P{TRiP.JF03241} NA heat-shock construct P{hsp70-dup.10(A).MYC} NA P{hsp70-dup.C.MYC} NA P{hsp70-dup.MYC} NA P{hsp70-dup.N.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}dupk03308 No P{lacW}l(2)SH0686SH0686 No miscellaneous insertions P{PTT-GB}dupCB04090 NA PBac{PB}dupc05735 NA PBac{PB}dupc05782 NA insertion of mobile activating element P{EP}dupEP2060 NA P{Mae-UAS.6.11}B0323B0323 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) centrosome duplication inferred from mutant phenotype (Pandey et al., 2005) chorion-containing eggshell formation inferred from mutant phenotype (Schupbach and Wieschaus, 1991) cytokinesis inferred from mutant phenotype (Pandey et al., 2005) DNA endoreduplication inferred from mutant phenotype (Park and Asano, 2008) DNA replication inferred from mutant phenotype (Whittaker et al., 2000) DNA replication checkpoint inferred from mutant phenotype (Whittaker et al., 2000) mitotic sister chromatid separation inferred from mutant phenotype (Pandey et al., 2005)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Whittaker et al., 2000) nuclear origin of replication recognition complex inferred from direct assay (Whittaker et al., 2000) nucleus inferred from direct assay (Whittaker et al., 2000) replication fork inferred from direct assay (Claycomb et al., 2002)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Whittaker, 2000.6.15)
Biological Process
CV term Evidence References
DNA-dependent DNA replication non-traceable author statement (Whittaker, 2000.6.15) DNA replication traceable author statement (Lee and Orr-Weaver, 2003) eggshell chorion gene amplification traceable author statement (Lee and Orr-Weaver, 2003)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex non-traceable author statement (Whittaker, 2000.6.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dup - CG10158 experimental knowledge based (Guruharsha et al., 2011) dup - CG17494 experimental knowledge based (Guruharsha et al., 2011) dup - CG9754 experimental knowledge based (Guruharsha et al., 2011) dup - Cen experimental knowledge based (Guruharsha et al., 2011) dup - RAF2 experimental knowledge based (Guruharsha et al., 2011) dup - Ubqn experimental knowledge based (Guruharsha et al., 2011) dup - cmet experimental knowledge based (Guruharsha et al., 2011) dup - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dup - geminin experimental knowledge based (Guruharsha et al., 2011) dup - nxf2 experimental knowledge based (Guruharsha et al., 2011) dup - tlk experimental knowledge based (Guruharsha et al., 2011) dup - woc experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dup allele Gene References dupa1 geminin (Quinn et al., 2001) dupa3 BubR1 (Garner et al., 2001) mei-41 (Garner et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70606 DroID - A comprehensive database of gene and protein interactions. • FBgn0000996 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47121
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6F4SWP Dipteran inclusive ortholog search EOG6K9BMF Insect inclusive ortholog search EOG60ZPT3 Arthropod inclusive ortholog search EOG6X3FGS Metazoa inclusive ortholog search EOG6RJTVB
Orthologs in Drosophila Species (EOG6F4SWP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dup     Drosophila simulans   Dsim\GD25618 Y   Drosophila sechellia   Dsec\GM20140 Y   Drosophila erecta   Dere\GG22355 Y   Drosophila yakuba   Dyak\dup Y   Drosophila ananassae   Dana\GF11870 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20864 Y   Drosophila persimilis   Dper\GL20043 Y   Drosophila willistoni   Dwil\GK23207 Y   Drosophila virilis   Dvir\GJ19871 Y   Drosophila mojavensis   Dmoj\GI20103 Y   Drosophila grimshawi   Dgri\GH21650 Y
Orthologs in non-Drosophila Dipterans (EOG6K9BMF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008519   Anopheles gambiae Malaria mosquito  Agam\AGAP005321   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015848   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009958
Orthologs in non-Dipteran Insects (EOG60ZPT3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\dup   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000162   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22412   Atta cephalotes Leafcutter ant  Acep\ACEP23486   Atta cephalotes Leafcutter ant  Acep\ACEP25020   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22626   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22624   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14091   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15622   Linepithema humile Argentine ant  Lhum\LH21075   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13068   Solenopsis invicta Red fire ant  Sinv\SINV10210   Acyrthosiphon pisum Pea aphid  Apim\ACYPI060727   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009088   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000196   Acyrthosiphon pisum Pea aphid  Apim\ACYPI35312   Bombyx mori Silkmoth  Bmor\BGIBMGA011818   Pediculus humanus Human body louse  Phum\PHUM232500   Tribolium castaneum Red flour beetle  Tcas\TC003416
Orthologs in non-Insect Arthropods (EOG6X3FGS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW002268   Ixodes scapularis Deer tick  Isca\ISCW003133
Orthologs in non-Arthropod Metazoa (EOG6RJTVB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cdt-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002046gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002045gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003658gn   Danio rerio Zebrafish  Drer\cdt1   Xenopus tropicalis Western clawed frog  Xtro\cdt1   Gallus gallus Domestic chicken  Ggal\CDT1   Mus musculus House mouse  Mmus\Cdt1   Rattus norvegicus Norway rat  Rnor\Cdt1   Homo sapiens Human  Hsap\CDT1
Human Orthologs (1)
Gene OMIM HGNC Hsap\CDT1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25618 Drosophila sechellia Dsec\GM20140 Drosophila erecta Dere\GG22355 Drosophila yakuba Dyak\dup Drosophila ananassae Dana\GF11870 Drosophila pseudoobscura pseudoobscura Dpse\GA20864 Drosophila persimilis Dper\GL20043 Drosophila willistoni Dwil\GK23207 Drosophila virilis Dvir\GJ19871 Drosophila mojavensis Dmoj\GI20103 Drosophila grimshawi Dgri\GH21650
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	7275 dupa1/CyO 7276 dupa3/CyO 29562 y1 v1; P{TRiP.JF03241}attP2 10530 y1 w67c23; P{lacW}dupk03308/CyO 4983 cn1 dupPA77 bw1/CyO, l(2)DTS5131 8542 y1 w*/Dp(1;Y)y+; Dp(2;2)Cam12a, dpov1 b1 P{lacW}dupk03308/CyO
Kyoto	108857 y1 w67c23; P{lacW}dupk03308/CyO 107982 cn1 dupPA77 bw1/CyO, l(2)DTS5131 111160 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}dupk03308 /CyO y+
VDRC	v23131 w1118; P{GD13203}v23131 v23130 w1118; P{GD13203}v23130/TM3
Genomic Clones ( 1 )
	BACR03D24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 127 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35784
Other clones	yak-em_dup
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01230 LD03122 LD04783 LD05049 LD06804 LD06824 LD09281 LD09327 LD11105 LD12389 LD12533 LD14575 LD15242 LD18007 LD18708 LD19840 LD21604 LD22083 LD22176 LD22368 LD23219 LD27778 LD28630 LD29611 LD31683 LD33380 LD33619 LD36041 LD37362 LD37458 LD38182 LD38837 LD39081 LD39714 LD40596 LD42392 LD44737 LD47078 LD47385 RE02680 RE04007 RE08736 RE24378 RE24786 RE29925 RE31933 RE33392 RE33815 RE35338 RE37772 RE38283 RE38609 RE39030 RE40177 RE42483 RE46567 RE52061 RE56615 RE57451 RE59437 RE60084 RE62557 RE66762 RE72410 RE73443 RH18987 RH70160
Other clones	10109 16644 19060 21396 35574 55710 63657 71752 119921 121701 160863 163316 165900 191959 522089 CK01.16B.D8 CK01.21A.H2 CK01.21A.H3 CK01.84B.C7 Dmel_neb_014744_0315_1997 EC051429 EC051882 EC051903 EC053424 EC054412 EC054417 EC056063 EC056519 EK019461 EK068812 EK110030 EK133657 EK146261 EK174202 EK183828 EK190421 EK200151 EK264239 EK267759 EK270447 EK294648 EN01341 RP003051820 RP003165830 RP003186590 RP003219066 RP003222466 RP003225854 RP003291359 RP003338304 RP003356089 RP003370276 RP003420183 RP003439533 RP003452892 RP003467493 SD27946 UUGC0591
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000996 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47121
Antibody Information
	polyclonal (May et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: dup anon-WO0257455.31 (Whittaker, 1999.3.27, FlyBase, 1996-) Source for merge of: dup l(2)51Ec (Orr-Weaver, 1999.10.30) Source for merge of: dup l(2)k03308 (Whittaker et al., 2000) Source for merge of: speckled fs(2)PA77 (Yu et al., 1994)
Additional comments	Source for merge of dup anon-WO0257455.31 was sequence comparison (date:051113). (Whittaker, 1999.3.27, FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of compact chromatin when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells. (Kleino et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) dup plays a direct role in DNA replication. (Whittaker et al., 2000) Homozygous embryos show dramatically reduced levels of DNA replication after the 15th S phase. (Whittaker et al., 1999) Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology. (Roch et al., 1998) Embryonic lethal alleles show increased epithelial apoptosis, incomplete cuticle formation and cessation of post-blastoderm DNA replication. Female sterile alleles result in either failure of pronuclear fusion or arrest during early mitotic divisions. (Bruce et al., 1995) dup gene product is essential for proper DNA replication. (Smith et al., 1993) Mutations at the fs(2)51Fa locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080139 RefSeq (Proteins) • NP_524878 DDBJ / EMBL / GenBank • AA201828 AA438582 AAF58141 AAF99080 AAM49924 AF279146 AI518911 AQ034142 AQ074067 AX482663 AY118555 CZ470214 CZ470250 Entrez Gene - A searchable database of RefSeq genes. • 47121 UniProtKB/TrEMBL • Q7JVY2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CDT1 Geminin-binding domain-like (IPR014939)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70606 DroID - A comprehensive database of gene and protein interactions. • FBgn0000996 DRSC - Results from RNAi screens. • FBgn0000996 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000996 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8171-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000996 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47121 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/doubpkd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47121 modMine - Data generated by the modENCODE project. • FBgn0000996
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	19k (Whittaker, 1999.3.27, Whittaker et al., 1999) anon-WO0257455.31   CDT1 (Higa et al., 2003, Higa et al., 2006) Cdt1 (Christensen and Tye, 2003, Manak et al., 2003, Machida et al., 2005, Ghorbani et al., 2011, Lee et al., 2010, May et al., 2005, Purdy et al., 2005, Zielke et al., 2008, Narbonne-Reveau and Lilly, 2009, Hall et al., 2008, Lin et al., 2009) cdt1 (Hong et al., 2007, Unhavaithaya and Orr-Weaver, 2012) CDT1/DUP (Lipsick, 2004) cdt1/dup (Lee and Orr-Weaver, 2003) CG8171 (Boutros et al., 2004, Ramet et al., 2002, Altenhein et al., 2006, Goshima et al., 2007, Molnar et al., 2006, Grieder et al., 2007, Guo et al., 2011, Perkins et al., 2009) Dup (Christensen and Tye, 2003, Mihaylov et al., 2002, Maqbool et al., 2010, Lin et al., 2009, Ding and Macalpine, 2010) DUP (Tower, 2004, Park et al., 2007, Macalpine et al., 2010, Belyaeva et al., 2012) dup (Sandmann et al., 2007, Christensen and Cook, 2007.10.29, Buszczak et al., 2007, Goshima et al., 2007, Cayirlioglu et al., 2003, Hartl et al., 2007, Shibutani et al., 2007, Molnar et al., 2006, Grieder et al., 2007, Somma et al., 2008, Ghorbani et al., 2011, Hong et al., 2007, Pandey et al., 2005, May et al., 2005, Park and Asano, 2008, Zielke et al., 2008, Mehrotra et al., 2008, McGraw et al., 2008, Narbonne-Reveau and Lilly, 2009, Gause et al., 2010, Longworth et al., 2012, Park et al., 2011, Japanese National Institute of Genetics, 2012.5.21) DUP/CDT1 (Dove, 2002, Claycomb et al., 2002, Belyaeva et al., 2012) fs(2)51Fa (Underwood et al., 1990, ) fs(2)ltoPA77 (Schupbach and Wieschaus, 1991, ) fs(2)PA77 (Tower, 2004, Calvi et al., 1998, Orr-Weaver, 1991, ) l(2)51Ec (Whittaker, 1999.3.27, Smith et al., 1993, Underwood et al., 1990, ) l(2)k03308 (Wakabayashi-Ito et al., 2001, Sekelsky et al., 2000, Spradling et al., 1999, Roch et al., 1998, )
Name Synonym	double park (Purdy et al., 2005) Double-parked (Tower, 2004, Lin et al., 2009) double parked (Park et al., 2001, Whittaker, 1999.3.27, Foglietti et al., 2006, Lee et al., 2010, McGraw et al., 2008, Park et al., 2011, Érdi et al., 2012) double-parked (Garcia et al., 2007, Pandey et al., 2005, Mehrotra et al., 2008, Hall et al., 2008) Double parked (Mihaylov et al., 2002, May et al., 2005) doubleparked (Somma et al., 2008) Double Parked (Narbonne-Reveau and Lilly, 2009) female sterile(2)51Fa   lethal(2)51Ec   speckled (Bruce et al., 1995, )
Secondary FlyBase IDs
	FBgn0004160 FBgn0022220 FBgn0034016 FBgn0063791
References ( 114 )
Generate a list of	All references relating to this gene ( 114 )
List References by type	Research paper  ( 64 ) Supplementary material  ( 10 ) Review  ( 10 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 12 ) FlyBase analysis  ( 2 ) Conference report  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Patent  ( 1 )
Recent research papers ( 11 )
	Ables and Drummond-Barbosa, 2013, Development 140(3): 530--540 Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. [FBrf0220400] Kondo and Hayashi, 2013, Nature 494(7435): 125--129 Mitotic cell rounding accelerates epithelial invagination. [FBrf0220776] Belyaeva et al., 2012, PLoS ONE 7(1): e30035 Late Replication Domains in Polytene and Non-Polytene Cells of Drosophila melanogaster. [FBrf0217200] Liu et al., 2012, Mol. Biol. Cell 23(1): 200--212 Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex. [FBrf0217098] Longworth et al., 2012, PLoS Genet. 8(4): e1002618 A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity. [FBrf0218058] Unhavaithaya and Orr-Weaver, 2012, Genes Dev. 26(1): 31--36 Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity. [FBrf0217041] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Érdi et al., 2012, Autophagy 8(7): 1124--1135 Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. [FBrf0219844] Ghorbani et al., 2011, Dev. Biol. 358(1): 213--223 Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila. [FBrf0215247] Guo et al., 2011, Mol. Cell. Biol. 31(4): 639--651 Poly(A) Signals Located near the 5' End of Genes Are Silenced by a General Mechanism That Prevents Premature 3'-End Processing. [FBrf0212905] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...