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Gene Dmel\dup

General Information
Symbol	Dmel\dup	Species	D. melanogaster
Name	double parked	Annotation symbol	CG8171
Feature type	protein_coding_gene	FlyBase ID	FBgn0000996
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	CDT1, l(2)k03308, fs(2)PA77, l(2)51Ec, DUP/CDT1, CDT1/DUP, 19k
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51F11-51F11	Sequence location	2R:11,264,124..11,268,465 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene double parked is referred to in FlyBase by the symbol Dmel\dup (CG8171, FBgn0000996). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: chorion-containing eggshell formation; DNA replication checkpoint; mitotic sister chromatid separation; cytokinesis; DNA replication; antimicrobial humoral response; centrosome duplication; DNA endoreduplication. 20 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; mitotic cell cycle; metaphase plate; follicle cell; imaginal disc; S phase; cycle 16 embryo; mitotic metaphase. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA replication factor CDT1-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624994_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dup. Gene sequence location is 2R:11264124..11268465.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Park et al., 2011, PLoS Genet. 7(8): e1002241
FB2012_01	References Ding and Macalpine, 2010, PLoS Genet. 6(9): Sequence features BKN29289 HFA07088
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51F11-51F11   Limits computationally determined from genome sequence between P{PZ}scb01288 and P{lacW}dupk03308
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51F11-51F12   (determined by in situ hybridisation)   (Spradling et al., 1999) 51F11-51F12     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dup for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dup-RA FBtr0087387  NM_080139   3110   743
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dup-PA   FBpp0086519   83.5   743   10.46     NP_524878   AAF58141
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA replication factor CDT1-like (IPR014939)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201680   AA201828   AA201960   AA202804   AA263659   AA263733   AA390385   AA391186   AA392132   AA438439   AA438582   AA439893   AA440311   AA539011   AA539703   AA540370   AA735599   AA816333   AA817065   AA817194   AA940895   AA949036   AA949644   AA950101   AA951295   AA979115   AA979253   AE013599 AAF58141   AF279146 AAF99080   AI455239   AI456177   AI512747   AI515317   AI515518   AI516503   AI517989   AI518051   AI518585   AI518911   AI519301   AI519474   AI519880   AI520434   AQ034142   AQ074067   AX482663   AY118555 AAM49924   AY231682   BI163315   BI164345   BI168167   BI227677   BI231839   BI234251   BI235962   BI237208   BI237567   BI238962   BI240837   BI241256   BI241519   BI241844   BI242759   BI356361   BI362096   BI366508   BI370186   BI370723   BI372468   BI372892   BI374872   BI483813   BI578529   BI579416   BI581504   BI604709   BI633786   BQ103192   CO153134   CO186424   CO266409   CO273203   CO279163   CO288523   CO292427   CO298959   CO302288   CO316260   CO317354   CO318145   CO323414   CO330174   CZ470214   CZ470250   EC051429   EC051882   EC051903   EC053424   EC054412   EC054417   EC056063   EC056519   EC060437   EC061224   EC070093   EC074611   EC076957   EC077948   EC078220   EC078914   EC079807   EC086563   EC203163   EC209616   EC221456   EC221936   EC229221   EC229222   EC245929   EC249929   EC266318   ES695872   ES695875   EV590565   GH760585   GH783996   GH786473   GH819305   GH835139   GH862265   GH864262   GH867189   GH876080   GH882124   GH883643   GH901450   GH914492   GH919838
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JVY2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000996    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000996 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000996 expression level Developmental Stage   Expression Level embryo 00-02hr    12041 embryo 02-04hr    10821 embryo 04-06hr    12864 embryo 06-08hr    10907 embryo 08-10hr    7434 embryo 10-12hr    4056 embryo 12-14hr    3435 embryo 14-16hr    3773 embryo 16-18hr    3073 embryo 18-20hr    1596 embryo 20-22hr    6626 embryo 22-24hr    5107 larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day    2265 adult female 05day    5477 adult female 30day    5764 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12041) embryo 02-04hr  (10821) embryo 04-06hr  (12864) embryo 06-08hr  (10907) embryo 08-10hr  (7434) embryo 10-12hr  (4056) embryo 12-14hr  (3435) embryo 14-16hr  (3773) embryo 16-18hr  (3073) embryo 18-20hr  (1596) embryo 20-22hr  (6626) embryo 22-24hr  (5107) larva L1  (747) larva L2  (652) larva L3 12hr old  (486) larva L3 puffstage 1-2  (570) larva L3 puffstage 3-6  (616) larva L3 puffstage 7-9  (639) white prepupae new  (614) white prepupae 12hr  (916) white prepupae 24hr  (716) pupae 2d postWPP  (392) pupae 3d postWPP  (202) pupae 4d postWPP  (311) adult male 01day  (209) adult male 05day  (280) adult male 30day  (234) adult female 01day  (2265) adult female 05day  (5477) adult female 30day  (5764) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12041) embryo 02-04hr  (10821) embryo 04-06hr  (12864) embryo 06-08hr  (10907) embryo 08-10hr  (7434) embryo 10-12hr  (4056) embryo 12-14hr  (3435) embryo 14-16hr  (3773) embryo 16-18hr  (3073) embryo 18-20hr  (1596) embryo 20-22hr  (6626) embryo 22-24hr  (5107) larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day  (2265) adult female 05day  (5477) adult female 30day  (5764) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (12041) embryo 02-04hr  (10821) embryo 04-06hr  (12864) embryo 06-08hr  (10907) embryo 08-10hr    7434 embryo 10-12hr    4056 embryo 12-14hr    3435 embryo 14-16hr    3773 embryo 16-18hr    3073 embryo 18-20hr    1596 embryo 20-22hr    6626 embryo 22-24hr    5107 larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day    2265 adult female 05day    5477 adult female 30day    5764 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12041 embryo 02-04hr    10821 embryo 04-06hr    12864 embryo 06-08hr    10907 embryo 08-10hr    7434 embryo 10-12hr    4056 embryo 12-14hr    3435 embryo 14-16hr    3773 embryo 16-18hr    3073 embryo 18-20hr    1596 embryo 20-22hr    6626 embryo 22-24hr    5107 larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day    2265 adult female 05day    5477 adult female 30day    5764 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000996 expression level Developmental Stage   Expression Level embryo 00-02hr    12041 embryo 02-04hr    10821 embryo 04-06hr    12864 embryo 06-08hr    10907 embryo 08-10hr    7434 embryo 10-12hr    4056 embryo 12-14hr    3435 embryo 14-16hr    3773 embryo 16-18hr    3073 embryo 18-20hr    1596 embryo 20-22hr    6626 embryo 22-24hr    5107 larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day    2265 adult female 05day    5477 adult female 30day    5764 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12041) embryo 02-04hr  (10821) embryo 04-06hr  (12864) embryo 06-08hr  (10907) embryo 08-10hr  (7434) embryo 10-12hr  (4056) embryo 12-14hr  (3435) embryo 14-16hr  (3773) embryo 16-18hr  (3073) embryo 18-20hr  (1596) embryo 20-22hr  (6626) embryo 22-24hr  (5107) larva L1  (747) larva L2  (652) larva L3 12hr old  (486) larva L3 puffstage 1-2  (570) larva L3 puffstage 3-6  (616) larva L3 puffstage 7-9  (639) white prepupae new  (614) white prepupae 12hr  (916) white prepupae 24hr  (716) pupae 2d postWPP  (392) pupae 3d postWPP  (202) pupae 4d postWPP  (311) adult male 01day  (209) adult male 05day  (280) adult male 30day  (234) adult female 01day  (2265) adult female 05day  (5477) adult female 30day  (5764) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12041) embryo 02-04hr  (10821) embryo 04-06hr  (12864) embryo 06-08hr  (10907) embryo 08-10hr  (7434) embryo 10-12hr  (4056) embryo 12-14hr  (3435) embryo 14-16hr  (3773) embryo 16-18hr  (3073) embryo 18-20hr  1596 embryo 20-22hr  (6626) embryo 22-24hr  (5107) larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day  2265 adult female 05day  (5477) adult female 30day  (5764) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  12041 embryo 02-04hr  10821 embryo 04-06hr  12864 embryo 06-08hr  10907 embryo 08-10hr    7434 embryo 10-12hr    4056 embryo 12-14hr    3435 embryo 14-16hr    3773 embryo 16-18hr    3073 embryo 18-20hr    1596 embryo 20-22hr    6626 embryo 22-24hr    5107 larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day    2265 adult female 05day    5477 adult female 30day    5764 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12041 embryo 02-04hr    10821 embryo 04-06hr    12864 embryo 06-08hr    10907 embryo 08-10hr    7434 embryo 10-12hr    4056 embryo 12-14hr    3435 embryo 14-16hr    3773 embryo 16-18hr    3073 embryo 18-20hr    1596 embryo 20-22hr    6626 embryo 22-24hr    5107 larva L1    747 larva L2    652 larva L3 12hr old    486 larva L3 puffstage 1-2    570 larva L3 puffstage 3-6    616 larva L3 puffstage 7-9    639 white prepupae new    614 white prepupae 12hr    916 white prepupae 24hr    716 pupae 2d postWPP    392 pupae 3d postWPP    202 pupae 4d postWPP    311 adult male 01day    209 adult male 05day    280 adult male 30day    234 adult female 01day    2265 adult female 05day    5477 adult female 30day    5764 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000996    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000996 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000996 expression level Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  (1105.8) Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  (1105.8) Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000996 expression level Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  (1105.8) Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary  1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    376.4 Larval Midgut    40.7 Larval Hindgut    56.4 Larval Malpighian Tubules    26.8 Larval Fat Body    27.9 Larval Salivary Gland    200.8 Larval Trachea    85.025 Larval Carcass    100.1 Adult Head    21.3 Adult Eye    11.8 Adult Brain    18.4 Adult Thoracic-Abdominal Ganglion    18.8 Adult Crop    25.3 Adult Midgut    36.5 Adult Hindgut    17.3 Adult Malpighian Tubules    28.3 Adult Fat Body    25.2 Adult Salivary Gland no informative data Adult Heart    12.9 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    16.9 Adult Ovary    1105.8 Adult Testis    40.4 Adult Male Accessory Gland    26.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    21.3   NA  Eye    11.8   NA  Brain    18.4   376.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    18.8   NA  Crop    25.3   40.7  Midgut    36.5   56.4  Hindgut    17.3   26.8  Malpighian Tubules    28.3   27.9  Fat Body    25.2   200.8  Salivary Gland    no informative data   NA  Heart    12.9   85.025  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    16.9   NA  Ovary    1105.8   NA  Testis    40.4   NA  Male Accessory Gland    26.2   100.1  Carcass    39 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000996 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8171-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dupCB04090 dupl5 lethal, with Scer\GAL4pnr-MD237 dupGD13203 lethal | embryonic stage | recessive dupa1 dupa2 dupa3 dupa4 lethal | recessive dupk03308 Sterility Allele female sterile dupPA77 Other Phenotypes Allele cytokinesis defective dupa1 increased cell death dup10(A).hsp70.T:Hsap\MYC dupdsRNA.cRa duphsp70.T:Hsap\MYC mitotic cell cycle defective dupa1 dupa3 dupPA77 mitotic cell cycle defective (with dupa1) dupPA77 mitotic cell cycle defective (with dupPA77) dupa1 mitotic cell cycle defective | maternal effect dupunspecified Phenotype manifest in Allele cycle 16 embryo dupa1 dupa3 eye disc duphsp70.T:Hsap\MYC follicle cell dup10(A).hsp70.T:Hsap\MYC dupC.hsp70.T:Hsap\MYC duphsp70.T:Hsap\MYC imaginal disc dup10(A).hsp70.T:Hsap\MYC duphsp70.T:Hsap\MYC dupk03308 kinetochore | maternal effect dupunspecified metaphase plate dupa1 mitosis & nuclear chromosome dupa1 dupa3 mitotic cell cycle dupPA77 dupa1 dupa3 mitotic cell cycle (with dupa1) dupPA77 mitotic cell cycle (with dupPA77) dupa1 mitotic metaphase dupa1 dupa3 S phase dupa1 dupunspecified S phase | embryonic cycle 16 dupa1
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of dup Class Mutagen Stocks Known lesion dupk03308 P-element activity 3 Yes dupPA77 ethyl methanesulfonate 2 Yes dupa1 1 Yes dupa3 1 Yes dupa2 0 -- dupA3 0 -- dupa4 0 -- dupc05735 piggyBac transposase 0 -- dupc05782 piggyBac transposase 0 -- dupCB04090 P-element activity 0 Yes dupEP2060 P-element activity 0 -- dupl5 gamma ray 0 -- dupunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dup Class Mutagen Stocks Known lesion dupGD13203 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dupJF03241 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dup10(A).hsp70.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes dupC.hsp70.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dupdsRNA.cRa in vitro construct - RNAi 0 Yes duphsp70.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dupN.hsp70.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC346 (Christensen and Cook, 2007.10.29) Df(2R)Exel9015 (Ryder, 2004.4.26) Df(2R)Jp1 (Spradling et al., 1999, Sekelsky et al., 2000, Whittaker et al., 2000, BDGP Project Members, 1994-1999) Df(2R)l4 (Underwood et al., 1990) Df(2R)l13 (Underwood et al., 1990, Smith et al., 1993) Df(2R)XTE-11 (Underwood et al., 1990) Df(2R)XTE-18 (Sekelsky et al., 2000, Underwood et al., 1990, Schupbach and Wieschaus, 1991) Df(2R)XTED4 (Underwood et al., 1990)
Not disrupted in	Df(2R)Jp4 (Spradling et al., 1999, Sekelsky et al., 2000, BDGP Project Members, 1994-1999) Df(2R)Jp5 (BDGP Project Members, 1994-1999) Df(2R)knSA3 (Sekelsky et al., 2000) Df(2R)l4 (Underwood et al., 1990) Df(2R)XTE-58 (Underwood et al., 1990) Df(2R)XTED1 (Underwood et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13203} NA P{TRiP.JF03241} NA heat-shock construct P{hsp70-dup.10(A).MYC} NA P{hsp70-dup.C.MYC} NA P{hsp70-dup.MYC} NA P{hsp70-dup.N.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}dupk03308 No P{lacW}l(2)SH0686SH0686 No miscellaneous insertions P{PTT-GB}dupCB04090 NA PBac{PB}dupc05735 NA PBac{PB}dupc05782 NA insertion of mobile activating element P{EP}dupEP2060 NA P{Mae-UAS.6.11}B0323B0323 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) centrosome duplication inferred from mutant phenotype (Pandey et al., 2005) chorion-containing eggshell formation inferred from mutant phenotype (Schupbach and Wieschaus, 1991) cytokinesis inferred from mutant phenotype (Pandey et al., 2005) DNA endoreduplication inferred from mutant phenotype (Park and Asano, 2008) DNA replication inferred from mutant phenotype (Whittaker et al., 2000) DNA replication checkpoint inferred from mutant phenotype (Whittaker et al., 2000) mitotic sister chromatid separation inferred from mutant phenotype (Pandey et al., 2005)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Whittaker et al., 2000) nuclear origin of replication recognition complex inferred from direct assay (Whittaker et al., 2000) nucleus inferred from direct assay (Whittaker et al., 2000) replication fork inferred from direct assay (Claycomb et al., 2002)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Whittaker, 2000.6.15)
Biological Process
CV term Evidence References
DNA-dependent DNA replication non-traceable author statement (Whittaker, 2000.6.15) DNA replication traceable author statement (Lee and Orr-Weaver, 2003) eggshell chorion gene amplification traceable author statement (Lee and Orr-Weaver, 2003)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex non-traceable author statement (Whittaker, 2000.6.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dup allele Gene References dupa1 geminin (Quinn et al., 2001) dupa3 BubR1 (Garner et al., 2001) mei-41 (Garner et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70606 DroID - A comprehensive database of gene and protein interactions. • FBgn0000996 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47121
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11870 Dere\GG22355 Dgri\GH21650 Dmoj\GI20103 Dper\GL20043 Dpse\GA20864 Dsec\GM20140 Dsim\GD25618 Dvir\GJ19871 Dwil\GK23207 Dyak\dup
Curated drosophilid orthologs	Dpse\GA20864   Dyak\dup
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008519-PA Aedes aegypti (mosquito) AGAP005321-PA Anopheles gambiae (mosquito) XP_393349.3 Apis mellifera (honey bee) XP_001949671.1 Acyrthosiphon pisum (pea aphid) At3g54710.1 Arabidopsis thaliana (wall cress) 85078 Batrachochytrium dendrobatidis (chytrid fungus) XP_001893106.1 Brugia malayi (roundworm nematode) BGIBMGA011818-PA Bombyx mori (silk worm) ENSBTAP00000048486 Bos taurus (bovine) CBP30849 Caenorhabditis briggsae (nematode) CE22447 Caenorhabditis elegans (worm) ENSCAFP00000029426 Canis familiaris (dog) CPIJ009958 Culex pipens (mosquito) ENSCPOP00000018827 Cavia porcellus (guinea pig) RP29297 Caenorhabditis remanei (nematode) ENSCSAVP00000004973 Ciona savignyi (sedentary tunicate) ENSDARP00000068049 Danio rerio (zebra fish) ENSECAP00000004068 Equus caballus (horse) ENSGACP00000003139 Gymnopilus aculeatus (mushroom) ENSP00000301019 Homo sapiens (human) ISCW003133-PA Ixodes scapularis (deer tick) ENSMODP00000004984 Monodelphis domestica (gray opossum) ENSMMUP00000018173 Macaca mulatta (rhesus monkey) ENSMUSP00000006760 Mus musculus (house mouse) XP_001603997.1 Nasonia vitripennis (wasp) ENSOANP00000021918 Ornithorynchus anatinus (platypus) ENSORLP00000000507 Oryzias latipes (japanese killifish) LOC_Os04g10650.1 Oryza sativa (asian rice) PHUM007792-PA Pediculus humanus (human body louse) PP18695 Pristionchus pacificus (nematode) 68809 Physcomitrella patens (moss) ENSPPYP00000008626 Pongo pygmaeus (orangutan) 831622 Populus trichocarpa (black cottonwood) ENSPTRP00000014432 Pan troglodytes (chimpanzee) ENSRNOP00000018923 Rattus norvegicus (norway rat) 5061292 Sorghum bicolor (sorghum) Smp_167540 Schistosoma mansoni (trematode parasite) XP_001197647.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969028.1 Tribolium castaneum (red flour beetle) ENSTNIP00000006540 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000012243 Takifugu rubripes (pufferfish Takifugu) 3694.m00045 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000024578 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13068 NV10080 LH21075 ISCW003133 ISCW002268 FBgn0067985 FBgn0225169 FBgn0207013 FBgn0196904 FBgn0175023 FBgn0080854 FBgn0157640 FBgn0142839 FBgn0129111 FBgn0114527 FBgn0088910 CPIJ015848 CPIJ009958 CPIJ008600 CPIJ018653 BGIBMGA011818 ACYPI35312 ACYPI009088 ACYPI000196 GB12839 AGAP005321 AAEL008519 PHUM232500 GLEAN_03416
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	7275 dupa1/CyO 7276 dupa3/CyO 29562 y1 v1; P{TRiP.JF03241}attP2 10530 y1 w67c23; P{lacW}dupk03308/CyO 4983 cn1 dupPA77 bw1/CyO, l(2)DTS5131
Kyoto	108857 y1 w67c23; P{lacW}dupk03308/CyO 107982 cn1 dupPA77 bw1/CyO, l(2)DTS5131 111160 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}dupk03308 /CyO y+
VDRC	v23131 w1118; P{GD13203}v23131 v23130 w1118; P{GD13203}v23130/TM3
Genomic Clones ( 1 )
	BACR03D24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 127 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35784
Other clones	yak-em_dup
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01230 LD03122 LD04783 LD05049 LD06804 LD06824 LD09281 LD09327 LD11105 LD12389 LD12533 LD14575 LD15242 LD18007 LD18708 LD19840 LD21604 LD22083 LD22176 LD22368 LD23219 LD27778 LD28630 LD29611 LD31683 LD33380 LD33619 LD36041 LD37362 LD37458 LD38182 LD38837 LD39081 LD39714 LD40596 LD42392 LD44737 LD47078 LD47385 RE02680 RE04007 RE08736 RE24378 RE24786 RE29925 RE31933 RE33392 RE33815 RE35338 RE37772 RE38283 RE38609 RE39030 RE40177 RE42483 RE46567 RE52061 RE56615 RE57451 RE59437 RE60084 RE62557 RE66762 RE72410 RE73443 RH18987 RH70160
Other clones	10109 16644 19060 21396 35574 55710 63657 71752 119921 121701 160863 163316 165900 191959 522089 CK01.16B.D8 CK01.21A.H2 CK01.21A.H3 CK01.84B.C7 Dmel_neb_014744_0315_1997 EC051429 EC051882 EC051903 EC053424 EC054412 EC054417 EC056063 EC056519 EK019461 EK068812 EK110030 EK133657 EK146261 EK174202 EK183828 EK190421 EK200151 EK264239 EK267759 EK270447 EK294648 EN01341 RP003051820 RP003165830 RP003186590 RP003219066 RP003222466 RP003225854 RP003291359 RP003338304 RP003356089 RP003370276 RP003420183 RP003439533 RP003452892 RP003467493 SD27946 UUGC0591
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000996 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47121
Antibody Information
	polyclonal (May et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: dup anon-WO0257455.31 (Whittaker, 1999.3.27, FlyBase, 1996-) Source for merge of: dup l(2)51Ec (Orr-Weaver, 1999.10.30) Source for merge of: dup l(2)k03308 (Whittaker et al., 2000) Source for merge of: speckled fs(2)PA77 (Yu et al., 1994)
Additional comments	Source for merge of dup anon-WO0257455.31 was sequence comparison (date:051113). (Whittaker, 1999.3.27, FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of compact chromatin when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells. (Kleino et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) dup plays a direct role in DNA replication. (Whittaker et al., 2000) Homozygous embryos show dramatically reduced levels of DNA replication after the 15th S phase. (Whittaker et al., 1999) Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology. (Roch et al., 1998) Embryonic lethal alleles show increased epithelial apoptosis, incomplete cuticle formation and cessation of post-blastoderm DNA replication. Female sterile alleles result in either failure of pronuclear fusion or arrest during early mitotic divisions. (Bruce et al., 1995) dup gene product is essential for proper DNA replication. (Smith et al., 1993) Mutations at the fs(2)51Fa locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080139 RefSeq (Proteins) • NP_524878 DDBJ / EMBL / GenBank • AA201828 AA438582 AAF58141 AAF99080 AAM49924 AF279146 AI518911 AQ034142 AQ074067 AX482663 AY118555 CZ470214 CZ470250 Entrez Gene - A searchable database of RefSeq genes. • 47121 UniProtKB/TrEMBL • Q7JVY2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA replication factor CDT1-like (IPR014939)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70606 DroID - A comprehensive database of gene and protein interactions. • FBgn0000996 DRSC - Results from RNAi screens. • FBgn0000996 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000996 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8171-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000996 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47121 InParanoid A subset of ortholog calls from InParanoid. • AAEL008519-PA Aedes aegypti (mosquito) AGAP005321-PA Anopheles gambiae (mosquito) XP_393349.3 Apis mellifera (honey bee) XP_001949671.1 Acyrthosiphon pisum (pea aphid) At3g54710.1 Arabidopsis thaliana (wall cress) 85078 Batrachochytrium dendrobatidis (chytrid fungus) XP_001893106.1 Brugia malayi (roundworm nematode) BGIBMGA011818-PA Bombyx mori (silk worm) ENSBTAP00000048486 Bos taurus (bovine) CBP30849 Caenorhabditis briggsae (nematode) CE22447 Caenorhabditis elegans (worm) ENSCAFP00000029426 Canis familiaris (dog) CPIJ009958 Culex pipens (mosquito) ENSCPOP00000018827 Cavia porcellus (guinea pig) RP29297 Caenorhabditis remanei (nematode) ENSCSAVP00000004973 Ciona savignyi (sedentary tunicate) ENSDARP00000068049 Danio rerio (zebra fish) ENSECAP00000004068 Equus caballus (horse) ENSGACP00000003139 Gymnopilus aculeatus (mushroom) ENSP00000301019 Homo sapiens (human) ISCW003133-PA Ixodes scapularis (deer tick) ENSMODP00000004984 Monodelphis domestica (gray opossum) ENSMMUP00000018173 Macaca mulatta (rhesus monkey) ENSMUSP00000006760 Mus musculus (house mouse) XP_001603997.1 Nasonia vitripennis (wasp) ENSOANP00000021918 Ornithorynchus anatinus (platypus) ENSORLP00000000507 Oryzias latipes (japanese killifish) LOC_Os04g10650.1 Oryza sativa (asian rice) PHUM007792-PA Pediculus humanus (human body louse) PP18695 Pristionchus pacificus (nematode) 68809 Physcomitrella patens (moss) ENSPPYP00000008626 Pongo pygmaeus (orangutan) 831622 Populus trichocarpa (black cottonwood) ENSPTRP00000014432 Pan troglodytes (chimpanzee) ENSRNOP00000018923 Rattus norvegicus (norway rat) 5061292 Sorghum bicolor (sorghum) Smp_167540 Schistosoma mansoni (trematode parasite) XP_001197647.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969028.1 Tribolium castaneum (red flour beetle) ENSTNIP00000006540 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000012243 Takifugu rubripes (pufferfish Takifugu) 3694.m00045 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000024578 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/doubpkd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47121 modMine - Data generated by the modENCODE project. • FBgn0000996 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13068 NV10080 LH21075 ISCW003133 ISCW002268 FBgn0067985 FBgn0225169 FBgn0207013 FBgn0196904 FBgn0175023 FBgn0080854 FBgn0157640 FBgn0142839 FBgn0129111 FBgn0114527 FBgn0088910 CPIJ015848 CPIJ009958 CPIJ008600 CPIJ018653 BGIBMGA011818 ACYPI35312 ACYPI009088 ACYPI000196 GB12839 AGAP005321 AAEL008519 PHUM232500 GLEAN_03416
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	19k (Whittaker, 1999.3.27, Whittaker et al., 1999) anon-WO0257455.31   CDT1 (Higa et al., 2003, Higa et al., 2006) Cdt1 (Christensen and Tye, 2003, Manak et al., 2003, Machida et al., 2005, May et al., 2005, Purdy et al., 2005, Zielke et al., 2008, Narbonne-Reveau and Lilly, 2009, Hall et al., 2008, Lin et al., 2009) cdt1 (Hong et al., 2007) CDT1/DUP (Lipsick, 2004) cdt1/dup (Lee and Orr-Weaver, 2003) CG8171 (Boutros et al., 2004, Ramet et al., 2002, Altenhein et al., 2006, Goshima et al., 2007, Molnar et al., 2006, Grieder et al., 2007, Perkins et al., 2009) Dup (Christensen and Tye, 2003, Mihaylov et al., 2002, Lin et al., 2009, Ding and Macalpine, 2010) DUP (Tower, 2004, Park et al., 2007, Macalpine et al., 2010) dup (Sandmann et al., 2007, Christensen and Cook, 2007.10.29, Buszczak et al., 2007, Goshima et al., 2007, Cayirlioglu et al., 2003, Hartl et al., 2007, Shibutani et al., 2007, Molnar et al., 2006, Grieder et al., 2007, Somma et al., 2008, Hong et al., 2007, Pandey et al., 2005, May et al., 2005, Park and Asano, 2008, Zielke et al., 2008, Mehrotra et al., 2008, McGraw et al., 2008, Narbonne-Reveau and Lilly, 2009, Gause et al., 2010, Park et al., 2011) DUP/CDT1 (Dove, 2002, Claycomb et al., 2002) fs(2)51Fa (Underwood et al., 1990, ) fs(2)ltoPA77 (Schupbach and Wieschaus, 1991, ) fs(2)PA77 (Tower, 2004, Calvi et al., 1998, Orr-Weaver, 1991, ) l(2)51Ec (Whittaker, 1999.3.27, Smith et al., 1993, Underwood et al., 1990, ) l(2)k03308 (Wakabayashi-Ito et al., 2001, Sekelsky et al., 2000, Spradling et al., 1999, Roch et al., 1998, )
Name Synonym	double park (Purdy et al., 2005) Double-parked (Tower, 2004, Lin et al., 2009) double parked (Park et al., 2001, Whittaker, 1999.3.27, Foglietti et al., 2006, McGraw et al., 2008, Park et al., 2011) double-parked (Garcia et al., 2007, Pandey et al., 2005, Mehrotra et al., 2008, Hall et al., 2008) Double parked (Mihaylov et al., 2002, May et al., 2005) doubleparked (Somma et al., 2008) Double Parked (Narbonne-Reveau and Lilly, 2009) female sterile(2)51Fa   lethal(2)51Ec   speckled (Bruce et al., 1995, )
Secondary FlyBase IDs
	FBgn0004160 FBgn0022220 FBgn0034016 FBgn0063791
References ( 98 )
Generate a list of	All references relating to this gene ( 98 )
List References by type	Research paper  ( 52 ) Supplementary material  ( 8 ) Review  ( 10 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 12 ) FlyBase analysis  ( 2 ) Conference report  ( 2 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 1 ) Patent  ( 1 )
Recent research papers ( 4 )
	Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Ding and Macalpine, 2010, PLoS Genet. 6(9): Preferential Re-Replication of Drosophila Heterochromatin in the Absence of Geminin. [FBrf0211780] Gause et al., 2010, Mol. Cell. Biol. 30(20): 4940--4951 Dosage-sensitive regulation of Cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl. [FBrf0211896] Macalpine et al., 2010, Genome Res. 20(2): 201--211 Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. [FBrf0209851] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...