Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fy using the Feature Mapper tool.
Low levels of fy expression are detected in all developmental stages. High levels are detected in 2 day-old pupae, at the time of prehair initiation. Significant expresssion levels are detected in embryos and adult females. fy transcript is detected in all wing cells of 2 day old pupae.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fy in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Functions downstream of fz for planar polarity in the wing. in and fy are needed in cells receiving and responding to a fz dependent intercellular signal. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy.
Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. Vinblastine enhances the multiple wing hair phenotype of in and fy mutants indicating that the microtubule cytoskeleton has a function independent of the fz pathway. In the wing as in the abdomen in and fy are epistatic to fz as double mutants resemble in and fy and not fz. In the eye fz is epistatic to in and fy. In terms of the wing eversion phenotype of fz, in and fy appear to be epistatic to fz.
Ives, Jan. 1939.