FB2019_06, released Dec 19, 2019

Gene: Dmel\fz

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General Information
Symbol
Dmel\fz
Species
D. melanogaster
Name
frizzled
Annotation Symbol
CG17697
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001085
Gene Model Status
Current
Stock Availability
32 publicly available
Gene Snapshot
frizzled (fz) encodes the founding member of the Fz family of receptors for Wnt ligands. It is part of Wnt signaling and planar cell polarity pathways. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
Fz1, Dfz1, Frizzled 1, frz, DFz
Key Links
Genomic Location
Cytogenetic map
70D4-70D5
Sequence location
3L:14,274,343..14,368,639 [+]
Recombination map
3-42
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor Fz/Smo family. (P18537)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Wnt-activated receptor activity; Wnt-protein binding
Predictions / Assertions
Wnt-activated receptor activity; Wnt-protein binding
Summaries
Gene Group (FlyBase)
FRIZZLED-TYPE RECEPTORS -
The frizzled gene family belong to Class F GPCRs. Frizzled GPCRs are characterized by a large N-terminal extracellular domain containing a cysteine-rich ligand-binding domain. The frizzled genes were first identified in Drosophila. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzleds function in three distinct signaling pathways - the planar cell polarity pathway, the canonical Wnt/β-catenin pathway, and the Wnt/calcium pathway. (Adapted from FBrf0222139).
Pathway (FlyBase)
Wnt-TCF Signaling Pathway Core Components -
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Protein Function (UniProtKB)
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
(UniProt, P18537)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
fz: frizzled
thumb
fz: frizzled
From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 85.
Hairs on thorax directed irregularly toward midline. Thoracic bristles also inturned and often wavy. Postverticals may turn outward. Hairs on wing edge and feet nearly erect; trichomes on wings of flies carrying weaker alleles tend to form swirls rather than lying parallel to one another and pointing distally; stronger alleles can cause random orientation of trichomes. Polarity of chaetae deranged in characteristic ways on wings, notum, halteres, legs, tergites, and sternites; fz M+ clones in M/+ wings cause derangement of polarity in M/+ cells surrounding clone (Gubb and Garcia-Bellido, 1982, J. Embryol. Exp. Morphol. 68: 37-57). In a wild-type background clones of wing cells homozygous for fz alleles that cause eye roughening, but not of those without effect on eye texture, cause adjacent normal trichomes in regions distal, anterior, and posterior, but not proximal to the clone, to orient toward the clone rather than distally as they normally do; no effect on trichomes on opposite surface of the wing (Vinson and Adler, 1987, Nature 329: 549-51). Wing may be reduced. A low level of doubling of trichomes and splitting of chaetae observed. Sex combs may be irregular. Most alleles cause eyes to be rough. Two weak alleles, fz24 and fz34 and two neomorphic alleles, fz13 and fz20, have normal eye textures. Extra leg joints tend to form as mirror-image duplications proximal to the normal joints on tarsal segments one to four. Also polarities of bristles, hairs, and bracts on legs abnormal (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). RK2.
fz13
A neomorphic allele causing severe disruption of trichome orientation in the costal wing cell, a region little affected by most alleles; phenotype of homozygote more severe than that of hemizygote. Also unlike other alleles, homozygous clones of fz13 cells in the wing do not affect orientation of trichomes in surrounding normal cells. A third notable feature of fz13 is that it is without effect on eye texture.
fz20
Like fu13.
Summary (Interactive Fly)
transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene - a part of Wnt signaling and planar cell polarity pathways
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\fz or the JBrowse view of Dmel\fz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216884.
gene_with_stop_codon_read_through ; SO:0000697
Transposon inserted in intron
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.53
Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fz-RA
FBtr0075743
NM_080073
3817
581
fz-RC
FBtr0330102
NM_001274907
3817
612
Additional Transcript Data and Comments
Reported size (kB)
4.0, >4.0 (northern blot)
(Adler et al., 1990)
4.0 (northern blot)
(Vinson et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
fz-PA
FBpp0075485
64.8
581
8.22
NP_524812
AAF49746
fz-PC
FBpp0303135
68.0
612
7.95
NP_001261836
AGB94529
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
60, 42 (kD observed)
(Krasnow and Adler, 1994)
62, 60 (kD observed)
(Park et al., 1994)
62, 60 (kD observed); 62 (kD predicted)
(Park et al., 1994)
581, 415 (aa)
(Adler et al., 1990)
581 (aa)
(Vinson et al., 1989)
Comments
Experiments with heat shock driven transgenes demonstrate that the shorter 415aa form of the fz protein is unable to rescue fz mutations. No endogenous protein of this size was detected.
(Krasnow and Adler, 1994)
Experiments with heat shock driven transgenes demonstrate that only the longer 581aa form of the fz protein shows any activity and rescues fz mutations. Overexpression results in two distinct tissue polarity phenotypes.
(Krasnow and Adler, 1994)
The fz protein contains and odd number of transmembrane domains and is glycosylated.
(Park et al., 1994)
One of a couple of protein products.
(FlyBase, 1992-)
The 415aa fz protein is essentially a carboxy-terminal truncated class I fz protein. It contains the seven transmembrane domains and is also likely to be an integral membrane protein.
(Adler et al., 1990)
The fz protein has 7 putative transmembrane domains.
(Vinson et al., 1989)
External Data
Subunit Structure (UniProtKB)
Interacts with ATP6AP2.
(UniProt, P18537)
Domain
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands.
(UniProt, P18537)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fz using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (38 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Wnt-activated receptor activity
inferred from direct assay
(Povelones and Nusse, 2005)
Wnt-protein binding
(Wu and Nusse, 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Wnt-activated receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
Wnt-protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (32 terms)
Terms Based on Experimental Evidence (32 terms)
CV Term
Evidence
References
asymmetric cell division
inferred from mutant phenotype
(Katanaev and Tomlinson, 2006)
axon extension
inferred from mutant phenotype
(Srahna et al., 2006)
border follicle cell migration
inferred from mutant phenotype
(Bastock and Strutt, 2007)
canonical Wnt signaling pathway
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Bhanot et al., 1999, Zhang and Carthew, 1998)
inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084
(Povelones and Nusse, 2005)
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084
(Chen and Struhl, 1999)
cardioblast cell fate specification
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Bhanot et al., 1999)
chitin-based larval cuticle pattern formation
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Povelones and Nusse, 2005)
compound eye morphogenesis
inferred from mutant phenotype
(Kryuchkov et al., 2011)
establishment of cell polarity
inferred from mutant phenotype
(Strutt, 2001)
establishment of epithelial cell apical/basal polarity
inferred from mutant phenotype
(Ma et al., 2003)
establishment of imaginal disc-derived wing hair orientation
inferred from expression pattern
(Strutt, 2001)
inferred from mutant phenotype
(Klein et al., 2006, Strutt, 2001, Usui et al., 1999)
establishment of ommatidial planar polarity
inferred from mutant phenotype
(Klein et al., 2006, Strutt et al., 2006, Yang et al., 2002, Zhang and Carthew, 1998, Zheng et al., 1995)
establishment of planar polarity
inferred from mutant phenotype
(Povelones and Nusse, 2005, Usui et al., 1999)
establishment or maintenance of cell polarity
inferred from mutant phenotype
(assigned by UniProt )
(Vinson et al., 1989)
G protein-coupled receptor signaling pathway
inferred from genetic interaction with FLYBASE:Gαs; FB:FBgn0001123
(Nichols et al., 2013)
germ-line stem-cell niche homeostasis
inferred from mutant phenotype
(Wang et al., 2015)
homophilic cell adhesion via plasma membrane adhesion molecules
inferred from mutant phenotype
(Usui et al., 1999)
imaginal disc-derived wing hair organization
inferred from genetic interaction with FLYBASE:ck; FB:FBgn0000317
(Winter et al., 2001)
inferred from genetic interaction with FLYBASE:sqh; FB:FBgn0003514
(Winter et al., 2001)
inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020
(Winter et al., 2001)
inferred from genetic interaction with FLYBASE:Rok; FB:FBgn0026181
(Winter et al., 2001)
inferred from genetic interaction with FLYBASE:zip; FB:FBgn0265434
(Winter et al., 2001)
imaginal disc-derived wing hair site selection
inferred from mutant phenotype
(Adler et al., 1994)
imaginal disc-derived wing margin morphogenesis
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084
(Chen and Struhl, 1999)
midgut development
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Bhanot et al., 1999)
morphogenesis of a polarized epithelium
inferred from mutant phenotype
(Classen et al., 2005)
neuron fate specification
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Bhanot et al., 1999)
ommatidial rotation
inferred from mutant phenotype
(Fetting et al., 2009, Zheng et al., 1995)
positive regulation of axon extension
inferred from genetic interaction with FLYBASE:DAAM; FB:FBgn0025641
(Gombos et al., 2015)
positive regulation of axon guidance
inferred from mutant phenotype
(Gombos et al., 2015)
R3/R4 cell fate commitment
inferred from mutant phenotype
(Nichols et al., 2013)
regulation of actin filament bundle assembly
inferred from genetic interaction with FLYBASE:Rok; FB:FBgn0026181
(Winter et al., 2001)
regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
regulation of tube length, open tracheal system
inferred from mutant phenotype
(Chung et al., 2009)
salivary gland morphogenesis
inferred from mutant phenotype
(Harris and Beckendorf, 2007)
segment polarity determination
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084
(Chen and Struhl, 1999)
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Povelones and Nusse, 2005, Bhanot et al., 1999)
sensory organ precursor cell fate determination
inferred from mutant phenotype
(Bellaiche et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
establishment of ommatidial planar polarity
traceable author statement
(Tree et al., 2002)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
colocalizes_with endosome
inferred from direct assay
(Shimada et al., 2006)
integral component of plasma membrane
inferred from direct assay
(Povelones and Nusse, 2005, Park et al., 1994)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
non-traceable author statement
(assigned by UniProt )
(Adler et al., 1990)
plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
wing
(Park et al., 1994)
pupal stage P5(ii)
epithelium of wing

Comment: reference states 18h APF

(Hermle et al., 2013)
pupal stage P6
epithelium of wing

Comment: reference states 28h APF

(Hermle et al., 2013)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
imaginal disc
(Park et al., 1994)
embryonic/larval central nervous system
(Park et al., 1994)
wing disc
(Park et al., 1994)
Additional Descriptive Data
fz protein is detected at low abundance in samples from wing discs, other imaginal discs, and CNS and appears as a doublet.
(Park et al., 1994)
fz protein is apically located within pupal wing cells.
(Park et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with endosome
inferred from direct assay
(Shimada et al., 2006)
integral component of plasma membrane
inferred from direct assay
(Povelones and Nusse, 2005, Park et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fz in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 104 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 150 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fz
Transgenic constructs containing regulatory region of fz
Deletions and Duplications ( 27 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with fz19)
viable (with fz21)
viable (with fz23)
Sterility
Allele
fertile
Other Phenotypes
Allele
cell polarity defective
cell polarity defective, with Scer\GAL471B
cell polarity defective, with Scer\GAL4dpp.blk1
cell polarity defective, with Scer\GAL4ptc-559.1
cell polarity defective (with fz19)
cell polarity defective (with fz20)
cell shape defective | embryonic stage, with Scer\GAL4svp.PT
neuroanatomy defective (with fz23)
neuroanatomy defective (with fz30)
neuroanatomy defective | dominant
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
planar polarity defective
planar polarity defective, with Scer\GAL469B
planar polarity defective, with Scer\GAL471B
planar polarity defective, with Scer\GAL4ap-md544
planar polarity defective, with Scer\GAL4Bx-MS1096
planar polarity defective, with Scer\GAL4C-765
planar polarity defective, with Scer\GAL4Dll-md23
planar polarity defective, with Scer\GAL4dpp.blk1
planar polarity defective, with Scer\GAL4dpp.PS
planar polarity defective, with Scer\GAL4en-e16E
planar polarity defective, with Scer\GAL4en-e16E, fz15
planar polarity defective, with Scer\GAL4en-e16E, fzUAS.cSa
planar polarity defective, with Scer\GAL4hh-Gal4
planar polarity defective, with Scer\GAL4hh-Gal4, fz21
planar polarity defective, with Scer\GAL4hh-Gal4, fzUAS.cSa
planar polarity defective, with Scer\GAL4hs.2sev
planar polarity defective, with Scer\GAL4hs.2sev, fzarm.EGFP
planar polarity defective, with Scer\GAL4hs.2sev, fzUAS.cAa
planar polarity defective, with Scer\GAL4pnr-MD237
planar polarity defective, with Scer\GAL4salm-459.2
planar polarity defective, with Scer\GAL4sev.PM181
planar polarity defective, with Scer\GAL4αTub84B.PL
planar polarity defective (with Df(3L)fz-D21)
planar polarity defective (with fz15)
planar polarity defective (with fz19)
planar polarity defective (with fz20)
planar polarity defective (with fz21)
planar polarity defective (with fz23)
planar polarity defective (with fz25)
planar polarity defective (with fz37)
planar polarity defective | adult stage
planar polarity defective | adult stage, with fz3A2.Act5C
planar polarity defective | adult stage, with fz4C3.Act5C
planar polarity defective | adult stage, with fz5E2.Act5C
planar polarity defective | adult stage, with fz6D2.Act5C
planar polarity defective | adult stage, with fz6E3.Act5C
planar polarity defective | adult stage, with fz6H4.Act5C
planar polarity defective | adult stage, with fz7A3.Act5C
planar polarity defective | adult stage, with fz8A4.Act5C
planar polarity defective | adult stage, with fz8D4.Act5C
planar polarity defective | adult stage, with fz8F2.Act5C
planar polarity defective | adult stage, with fz9C2.Act5C
planar polarity defective | adult stage, with fz11A2.Act5C
planar polarity defective | adult stage, with fz12F1.Act5C
planar polarity defective | adult stage, with fz14B2.Act5C
planar polarity defective | adult stage, with fz14D3.Act5C
planar polarity defective | adult stage, with fz15D4.Act5C
planar polarity defective | adult stage, with fz16A3.Act5C
planar polarity defective | adult stage, with fz17A1.Act5C
planar polarity defective | adult stage, with fz18B3.Act5C
planar polarity defective | adult stage, with fz19A3.Act5C
planar polarity defective | adult stage, with fz19B2.Act5C
planar polarity defective | adult stage, with fz19D3.Act5C
planar polarity defective | adult stage, with fz20F4.Act5C
planar polarity defective | adult stage, with fz21
planar polarity defective | adult stage, with fz22E1.Act5C
planar polarity defective | adult stage, with fz24C1.Act5C
planar polarity defective | adult stage, with fz25A3.Act5C
planar polarity defective | adult stage, with fz25B2.Act5C
planar polarity defective | adult stage, with fz26C1.Act5C
planar polarity defective | adult stage, with fz26C2.Act5C
planar polarity defective | adult stage, with fz27C2.Act5C
planar polarity defective | adult stage, with fz29D2.Act5C
planar polarity defective | adult stage, with fz30A3.Act5C
planar polarity defective | adult stage, with fz30E2.Act5C
planar polarity defective | adult stage, with fz34A3.Act5C
planar polarity defective | adult stage, with fz37E2.Act5C
planar polarity defective | adult stage, with fz37F3.Act5C
planar polarity defective | adult stage, with fz39B2.Act5C
planar polarity defective | adult stage, with fz39D1.Act5C
planar polarity defective | adult stage, with fz47B3.Act5C
planar polarity defective | adult stage, with fz49D2.Act5C
planar polarity defective | adult stage, with fz50E1.Act5C
planar polarity defective | adult stage, with fz53B4.Act5C
planar polarity defective | adult stage, with fz53D3.Act5C
planar polarity defective | adult stage, with fz63D2.Act5C
planar polarity defective | adult stage, with fz63E1.Act5C
planar polarity defective | adult stage, with fz68B1.Act5C
planar polarity defective | adult stage, with fz68G2.Act5C
planar polarity defective | adult stage, with fz70A2.1.Act5C
planar polarity defective | adult stage, with fz70A2.3.Act5C
planar polarity defective | adult stage, with fz70B2.Act5C
planar polarity defective | adult stage, with fz70B4.Act5C
planar polarity defective | adult stage, with fz72A4.Act5C
planar polarity defective | adult stage, with fz73A2.Act5C
planar polarity defective | adult stage, with fz76B1.Act5C
planar polarity defective | adult stage, with fz78A1.Act5C
planar polarity defective | adult stage, with fz79F3.Act5C
planar polarity defective | adult stage, with fzAAXXXA.Act5C.EGFP
planar polarity defective | adult stage, with fzIEAA.Act5C.EGFP
planar polarity defective | adult stage, with fzKLAA.Act5C.EGFP
planar polarity defective | adult stage (with fz19)
planar polarity defective | adult stage (with fz21)
planar polarity defective | adult stage (with fz23)
planar polarity defective | adult stage (with fz30)
planar polarity defective | cell autonomous, with Scer\GAL4ptc-559.1
planar polarity defective | cell non-autonomous
planar polarity defective | cell non-autonomous, with Scer\GAL4dpp.blk1
planar polarity defective | cell non-autonomous | recessive | somatic clone
planar polarity defective | cell non-autonomous | somatic clone
planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC
planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC, fz15
planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC, fzUAS.cSa
planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PP
planar polarity defective | cell non-autonomous | somatic clone (with fz15)
planar polarity defective | cell non-autonomous | somatic clone (with fz21)
planar polarity defective | dominant | heat sensitive
planar polarity defective | heat sensitive
planar polarity defective | pupal stage (with fz30)
planar polarity defective | pupal stage (with fz37)
planar polarity defective | recessive
planar polarity defective | recessive | somatic clone
planar polarity defective | somatic clone
planar polarity defective | somatic clone, with Scer\GAL4Ubx.PdC
planar polarity defective | somatic clone, with Scer\GAL4Ubx.PdC, fz15
planar polarity defective | somatic clone, with Scer\GAL4Ubx.PdC, fzUAS.cSa
planar polarity defective | somatic clone (with fz19)
planar polarity defective | somatic clone (with fz20)
visible
visible, with fz4C3.Act5C
visible, with fz6E3.Act5C
visible, with fz7A3.Act5C
visible, with fz8A4.Act5C
visible, with fz8F2.Act5C
visible, with fz11A2.Act5C
visible, with fz14B2.Act5C
visible, with fz17A1.Act5C
visible, with fz18B3.Act5C
visible, with fz19D3.Act5C
visible, with fz21
visible, with fz25A3.Act5C
visible, with fz25B2.Act5C
visible, with fz26C1.Act5C
visible, with fz26C2.Act5C
visible, with fz27C2.Act5C
visible, with fz30A3.Act5C
visible, with fz30E2.Act5C
visible, with fz37E2.Act5C
visible, with fz39B2.Act5C
visible, with fz39D1.Act5C
visible, with fz47B3.Act5C
visible, with fz50E1.Act5C
visible, with fz68G2.Act5C
visible, with fz70A2.1.Act5C
visible, with fz70A2.3.Act5C
visible, with fz70B4.Act5C
visible, with fz72A4.Act5C
visible, with fz73A2.Act5C
visible, with fz76B1.Act5C
visible, with fz79F3.Act5C
visible, with fzAAXXXA.Act5C.EGFP
visible, with fzIEAA.Act5C.EGFP
visible, with fzKLAA.Act5C.EGFP
visible, with Scer\GAL469B
visible, with Scer\GAL4C-765
visible, with Scer\GAL4Dll-md23
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ptc-559.1
visible (with fz13)
visible (with fz19)
visible (with fz23)
visible (with fz24)
visible (with fz25)
visible (with fz30)
visible (with fzCK)
visible (with fzCL)
visible (with fzED)
visible (with fzGL31)
visible (with fzHE11)
visible (with fzJB)
visible (with fzJW)
visible (with fzKW)
visible (with fzMG)
visible (with fzMP)
visible (with fzRN)
visible (with fzSN)
visible (with fzSY)
visible (with fzTT)
visible | adult stage
visible | adult stage (with fz21)
visible | adult stage (with fz30)
visible | cold sensitive
visible | cold sensitive (with fz30)
visible | cold sensitive (with fzHD21)
visible | heat sensitive
visible | recessive
visible | somatic clone
wild-type
wild-type, with Scer\GAL4Dll-md23
Phenotype manifest in
Allele
abdominal sternite bristle (with fz21)
abdominal sternite bristle (with fz30)
anterior-posterior compartment boundary of the wing blade, with Scer\GAL4ptc-559.1
arista lateral
axon & dorsal cluster neuron
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell (with fz15)
border follicle cell (with fz23)
border follicle cell | cell non-autonomous | somatic clone
border follicle cell | somatic clone
bract
denticle belt, with Scer\GAL4ptc-559.1
denticle belt, with Scer\GAL4VP16.mat.αTub67C
denticle row 1, with Scer\GAL4en-e16E
dorsal triple row, with Scer\GAL469B
embryonic/first instar larval cuticle, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval dorsal trunk (with fz21)
embryonic/larval dorsal trunk (with fz30)
embryonic/larval ostium | embryonic stage, with Scer\GAL4svp.PT
embryonic epidermis
embryonic neuroblast
external sensory organ precursor cell I
external sensory organ precursor cell I (with fz30)
external sensory organ precursor cell I (with fz37)
external sensory organ precursor cell I & centrosome (with fz30)
external sensory organ precursor cell I & centrosome (with fz37)
external sensory organ precursor cell I & spindle (with fz30)
external sensory organ precursor cell I & spindle (with fz37)
eye
eye, with Scer\GAL4hs.2sev
eye (with fz15)
eye (with fz21)
eye (with fz23)
eye (with fz30)
eye | heat sensitive
eye photoreceptor cell
eye photoreceptor cell | somatic clone
eye photoreceptor cell | somatic clone (with fz19)
eye photoreceptor cell | somatic clone (with fz20)
joint
joint | ectopic
joint | ectopic, with fz4C3.Act5C
joint | ectopic, with fz6E3.Act5C
joint | ectopic, with fz7A3.Act5C
joint | ectopic, with fz8A4.Act5C
joint | ectopic, with fz8F2.Act5C
joint | ectopic, with fz11A2.Act5C
joint | ectopic, with fz14B2.Act5C
joint | ectopic, with fz17A1.Act5C
joint | ectopic, with fz18B3.Act5C
joint | ectopic, with fz19D3.Act5C
joint | ectopic, with fz21
joint | ectopic, with fz25A3.Act5C
joint | ectopic, with fz25B2.Act5C
joint | ectopic, with fz26C1.Act5C
joint | ectopic, with fz26C2.Act5C
joint | ectopic, with fz27C2.Act5C
joint | ectopic, with fz30A3.Act5C
joint | ectopic, with fz30E2.Act5C
joint | ectopic, with fz37E2.Act5C
joint | ectopic, with fz39B2.Act5C
joint | ectopic, with fz39D1.Act5C
joint | ectopic, with fz47B3.Act5C
joint | ectopic, with fz50E1.Act5C
joint | ectopic, with fz68G2.Act5C
joint | ectopic, with fz70A2.1.Act5C
joint | ectopic, with fz70A2.3.Act5C
joint | ectopic, with fz70B4.Act5C
joint | ectopic, with fz72A4.Act5C
joint | ectopic, with fz73A2.Act5C
joint | ectopic, with fz76B1.Act5C
joint | ectopic, with fz79F3.Act5C
joint | ectopic, with fzAAXXXA.Act5C.EGFP
joint | ectopic, with fzIEAA.Act5C.EGFP
joint | ectopic, with fzKLAA.Act5C.EGFP
leg
leg, with fz4C3.Act5C
leg, with fz6E3.Act5C
leg, with fz7A3.Act5C
leg, with fz8A4.Act5C
leg, with fz8F2.Act5C
leg, with fz11A2.Act5C
leg, with fz14B2.Act5C
leg, with fz17A1.Act5C
leg, with fz18B3.Act5C
leg, with fz19D3.Act5C
leg, with fz21
leg, with fz25A3.Act5C
leg, with fz25B2.Act5C
leg, with fz26C1.Act5C
leg, with fz26C2.Act5C
leg, with fz27C2.Act5C
leg, with fz30A3.Act5C
leg, with fz30E2.Act5C
leg, with fz37E2.Act5C
leg, with fz39B2.Act5C
leg, with fz39D1.Act5C
leg, with fz47B3.Act5C
leg, with fz50E1.Act5C
leg, with fz68G2.Act5C
leg, with fz70A2.1.Act5C
leg, with fz70A2.3.Act5C
leg, with fz70B4.Act5C
leg, with fz72A4.Act5C
leg, with fz73A2.Act5C
leg, with fz76B1.Act5C
leg, with fz79F3.Act5C
leg, with fzAAXXXA.Act5C.EGFP
leg, with fzIEAA.Act5C.EGFP
leg, with fzKLAA.Act5C.EGFP
lens (with fz15)
lens (with fz30)
lymph gland derived hemocyte | third instar larval stage, with Scer\GAL4dome-PG14
macrochaeta
macrochaeta & adult abdomen | somatic clone | cell non-autonomous
macrochaeta & adult thorax
macrochaeta & eye
macrochaeta | ectopic, with Scer\GAL4ap-md52
macrochaeta | heat sensitive
medial triple row, with Scer\GAL469B
mesothoracic tergum, with Scer\GAL4ap-md544
mesothoracic tergum & sensory mother cell & spindle (with fz30)
mesothoracic tergum & sensory mother cell & spindle (with fz37)
microchaeta, with Scer\GAL4ap-md52
microchaeta & adult abdomen | somatic clone | cell non-autonomous
microchaeta & adult thorax | somatic clone | cell non-autonomous
mushroom body medial lobe (with fz23)
mushroom body medial lobe (with fz30)
ommatidium
ommatidium, with Scer\GAL4hs.2sev
ommatidium, with Scer\GAL4hs.2sev, fzarm.EGFP
ommatidium, with Scer\GAL4hs.2sev, fzUAS.cAa
ommatidium, with Scer\GAL4sev.PM181
ommatidium, with Scer\GAL4unspecified
ommatidium (with fz15)
ommatidium (with fz19)
ommatidium (with fz20)
ommatidium (with fz21)
ommatidium (with fz30)
ommatidium (with fz37)
ommatidium | somatic clone
ommatidium | somatic clone (with fz19)
ommatidium | somatic clone (with fz20)
photoreceptor cell R3 | ectopic
photoreceptor cell R3 | ectopic, with Scer\GAL4sev.PM181
photoreceptor cell R3 | supernumerary, with Scer\GAL4hs.2sev
photoreceptor cell R4
photoreceptor cell R4, with Scer\GAL4hs.2sev
photoreceptor cell R4, with Scer\GAL4sev.PM181
photoreceptor cell R4 | somatic clone
polar follicle cell, with Scer\GAL4slbo.2.6
polar follicle cell | somatic clone
presumptive embryonic salivary gland
presumptive embryonic salivary gland, with Scer\GAL4fkh.PZ
RP2 motor neuron
sensory mother cell
sensory mother cell & spindle, with Scer\GAL4ap-md52
spindle
spindle & external sensory organ precursor cell I (with fz30)
spindle & external sensory organ precursor cell I (with fz37)
tarsal segment
tarsal segment 1 & joint
tarsal segment 2
tarsal segment 3
tarsal segment 4
thorax
tormogen cell | supernumerary (with fz30)
tormogen cell | supernumerary (with fz37)
trichogen cell | supernumerary
trichome & abdominal tergite
trichome & adult abdomen, with Scer\GAL4hh-Gal4
trichome & adult abdomen | somatic clone
trichome & adult abdomen | somatic clone | cell non-autonomous
trichome & pleural membrane
trichome & pleural membrane, with Scer\GAL4en-e16E
trichome & pleural membrane, with Scer\GAL4en-e16E, fz15
trichome & pleural membrane, with Scer\GAL4en-e16E, fzUAS.cSa
trichome & pleural membrane, with Scer\GAL4hh-Gal4
trichome & pleural membrane, with Scer\GAL4hh-Gal4, fz21
trichome & pleural membrane, with Scer\GAL4hh-Gal4, fzUAS.cSa
trichome & pleural membrane, with Scer\GAL4αTub84B.PL
trichome & pleural membrane | somatic clone
trichome & pleural membrane | somatic clone, with Scer\GAL4Ubx.PdC
trichome & pleural membrane | somatic clone, with Scer\GAL4Ubx.PdC, fz15
trichome & pleural membrane | somatic clone, with Scer\GAL4Ubx.PdC, fzUAS.cSa
trichome & pleural membrane | somatic clone | cell non-autonomous
trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4Ubx.PdC
trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4Ubx.PdC, fz15
trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4Ubx.PdC, fzUAS.cSa
ventral triple row, with Scer\GAL469B
wing
wing, with Scer\GAL469B
wing, with Scer\GAL471B
wing, with Scer\GAL4ap-md544
wing (with Df(3L)fz-D21)
wing & macrochaeta
wing & microchaeta
wing & microchaeta, with Scer\GAL4ptc-559.1
wing & microchaeta | distal
wing & microchaeta | distal, with Scer\GAL4Dll-md23
wing | cell non-autonomous | somatic clone
wing | cold sensitive
wing | heat sensitive
wing | somatic clone
wing blade anterior compartment, with Scer\GAL4ptc-559.1
wing blade dorsal compartment (with fz21)
wing blade dorsal compartment (with fz23)
wing blade dorsal compartment | somatic clone (with fz15)
wing blade dorsal compartment | somatic clone (with fz23)
wing cell | P-stage
wing cell | P-stage | cell non-autonomous | somatic clone
wing cell | P-stage | somatic clone
wing disc
wing hair
wing hair, with Scer\GAL469B
wing hair, with Scer\GAL4Bx-MS1096
wing hair, with Scer\GAL4C-765
wing hair, with Scer\GAL4Dll-md23
wing hair, with Scer\GAL4dpp.blk1
wing hair, with Scer\GAL4dpp.PS
wing hair, with Scer\GAL4en-e16E
wing hair, with Scer\GAL4ptc-559.1
wing hair, with Scer\GAL4salm-459.2
wing hair (with fz15)
wing hair (with fz21)
wing hair (with fz23)
wing hair (with fz25)
wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1
wing hair | cell non-autonomous, with Scer\GAL4dpp.blk1
wing hair | cell non-autonomous | pupal stage | somatic clone (with fz15)
wing hair | cell non-autonomous | pupal stage | somatic clone (with fz21)
wing hair | cell non-autonomous | somatic clone
wing hair | cold sensitive
wing hair | heat sensitive
wing hair | P-stage, with Scer\GAL4dpp.blk1
wing hair | somatic clone
wing hair | supernumerary
wing hair | supernumerary, with Scer\GAL4Bx-MS1096
wing hair | supernumerary, with Scer\GAL4salm-459.2
wing hair | supernumerary (with fz13)
wing hair | supernumerary (with fz19)
wing hair | supernumerary (with fz23)
wing hair | supernumerary (with fz24)
wing hair | supernumerary (with fz25)
wing hair | supernumerary (with fz30)
wing hair | supernumerary (with fzCK)
wing hair | supernumerary (with fzCL)
wing hair | supernumerary (with fzED)
wing hair | supernumerary (with fzGL31)
wing hair | supernumerary (with fzHE11)
wing hair | supernumerary (with fzJB)
wing hair | supernumerary (with fzJW)
wing hair | supernumerary (with fzKW)
wing hair | supernumerary (with fzMG)
wing hair | supernumerary (with fzMP)
wing hair | supernumerary (with fzRN)
wing hair | supernumerary (with fzSN)
wing hair | supernumerary (with fzSY)
wing hair | supernumerary (with fzTT)
wing hair | supernumerary | cold sensitive (with fz30)
wing hair | supernumerary | cold sensitive (with fzHD21)
wing hair | supernumerary | heat sensitive
wing margin, with Scer\GAL4C-765
wing margin, with Scer\GAL4en-e16E
wing margin bristle
wing margin bristle, with Scer\GAL469B
wing margin bristle, with Scer\GAL4en-e16E
wing margin bristle | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PP
wing margin bristle | ectopic, with Scer\GAL471B
wing margin bristle | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FZD1
13 of 15
Yes
Yes
Hsap\FZD7
13 of 15
Yes
Yes
 
Hsap\FZD2
11 of 15
No
Yes
Hsap\FZD3
4 of 15
No
Yes
Hsap\FZD6
4 of 15
No
Yes
Hsap\FZD4
2 of 15
No
No
Hsap\FZD5
2 of 15
No
No
 
Hsap\FZD8
2 of 15
No
No
Hsap\FZD9
2 of 15
No
Yes
Hsap\FZD10
2 of 15
No
Yes
Hsap\SMO
2 of 15
No
No
Hsap\CORIN
1 of 15
No
No
Hsap\FRZB
1 of 15
No
No
Hsap\MFRP
1 of 15
No
No
Hsap\SFRP1
1 of 15
No
No
Hsap\SFRP2
1 of 15
No
No
Hsap\SFRP4
1 of 15
No
No
Hsap\SFRP5
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Fzd1
13 of 15
Yes
Yes
Mmus\Fzd7
13 of 15
Yes
Yes
Mmus\Fzd2
10 of 15
No
Yes
Mmus\Fzd3
4 of 15
No
Yes
 
Mmus\Fzd6
4 of 15
No
Yes
 
Mmus\Fzd4
2 of 15
No
No
 
Mmus\Fzd5
2 of 15
No
No
Mmus\Fzd8
2 of 15
No
No
 
Mmus\Fzd9
2 of 15
No
Yes
Mmus\Fzd10
2 of 15
No
Yes
Mmus\Corin
1 of 15
No
No
Mmus\Frzb
1 of 15
No
No
Mmus\Mfrp
1 of 15
No
No
Mmus\Sfrp1
1 of 15
No
No
 
Mmus\Sfrp2
1 of 15
No
No
Mmus\Sfrp4
1 of 15
No
No
Mmus\Sfrp5
1 of 15
No
No
Mmus\Smo
1 of 15
No
No
Rattus norvegicus (Norway rat) (18)
Rnor\Fzd1
12 of 13
Yes
Yes
 
Rnor\Fzd7
11 of 13
No
Yes
Rnor\Fzd2
9 of 13
No
Yes
 
Rnor\Fzd3
3 of 13
No
Yes
Rnor\Fzd6
3 of 13
No
Yes
Rnor\Fzd4
2 of 13
No
No
Rnor\Fzd9
2 of 13
No
Yes
Rnor\LOC100909849
2 of 13
No
No
Rnor\Cdk15
1 of 13
No
Yes
Rnor\Corin
1 of 13
No
No
Rnor\Frzb
1 of 13
No
No
Rnor\Fzd5
1 of 13
No
No
Rnor\Fzd8
1 of 13
No
No
Rnor\Mfrp
1 of 13
No
No
Rnor\Sfrp1
1 of 13
No
No
Rnor\Sfrp2
1 of 13
No
Yes
Rnor\Sfrp5
1 of 13
No
No
Rnor\Smo
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\fzd7
9 of 12
Yes
Yes
Xtro\fzd2
6 of 12
No
Yes
Xtro\fzd4
2 of 12
No
Yes
Xtro\fzd5
2 of 12
No
No
Xtro\fzd8
2 of 12
No
No
Xtro\fzd9
2 of 12
No
Yes
Xtro\fzd10
2 of 12
No
Yes
Xtro\col18a1
1 of 12
No
No
Xtro\corin
1 of 12
No
No
Xtro\frzb2
1 of 12
No
Yes
Xtro\frzb
1 of 12
No
No
Xtro\fzd1
1 of 12
No
Yes
Xtro\fzd3
1 of 12
No
Yes
Xtro\fzd6
1 of 12
No
Yes
Xtro\mfrp
1 of 12
No
Yes
Xtro\sfrp1
1 of 12
No
Yes
Xtro\sfrp2
1 of 12
No
Yes
Xtro\sfrp5
1 of 12
No
Yes
Xtro\sfrpx
1 of 12
No
Yes
Xtro\smo
1 of 12
No
No
Xtro\szl
1 of 12
No
Yes
Danio rerio (Zebrafish) (26)
Drer\fzd7b
13 of 15
Yes
Yes
Drer\fzd7a
12 of 15
No
Yes
Drer\fzd2
7 of 15
No
Yes
Drer\fzd3a
4 of 15
No
Yes
Drer\fzd3b
4 of 15
No
Yes
Drer\fzd1
3 of 15
No
Yes
Drer\fzd5
2 of 15
No
No
Drer\fzd6
2 of 15
No
Yes
Drer\fzd8a
2 of 15
No
No
Drer\fzd10
2 of 15
No
Yes
Drer\smo
2 of 15
No
No
Drer\corin
1 of 15
No
No
Drer\frzb
1 of 15
No
No
Drer\fzd4
1 of 15
No
No
Drer\fzd8b
1 of 15
No
No
Drer\fzd9a
1 of 15
No
No
Drer\fzd9b
1 of 15
No
No
Drer\LOC101884738
1 of 15
No
Yes
Drer\rcvrnb
1 of 15
No
No
Drer\sfrp1a
1 of 15
No
No
Drer\sfrp1b
1 of 15
No
Yes
Drer\sfrp2
1 of 15
No
No
Drer\sfrp2l
1 of 15
No
Yes
Drer\sfrp5
1 of 15
No
No
Drer\si:cabz01033205.3
1 of 15
No
No
Drer\szl
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\mom-5
14 of 15
Yes
Yes
Cele\cfz-2
3 of 15
No
No
Cele\lin-17
2 of 15
No
Yes
Cele\sfrp-1
2 of 15
No
Yes
Cele\mig-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT1G27135
1 of 9
Yes
Yes
Atha\AT4G15953
1 of 9
Yes
Yes
Atha\AT5G50345
1 of 9
Yes
Yes
Atha\OPT8
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919043M )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\fz
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004048
Drosophila simulans
Dsim\GD14489
Drosophila sechellia
Dsec\GM25464
Drosophila erecta
Dere\GG15682
Drosophila yakuba
Dyak\GE22012
Drosophila ananassae
Dana\GF24601
Drosophila pseudoobscura pseudoobscura
Dpse\GA14615
Drosophila persimilis
Dper\GL21009
Drosophila willistoni
Dwil\GK12696
Drosophila virilis
Dvir\fz
Drosophila mojavensis
Dmoj\GI11701
Drosophila grimshawi
Dgri\GH17099
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502Z7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004203
Musca domestica
House fly
Mdoa\17023407
Musca domestica
House fly
Mdoa\17026499
Glossina morsitans
Tsetse fly
Gmor\GMOY011100
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13221
Mayetiola destructor
Hessian fly
Mdes\Mdes019679
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRFZ6
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRFZ5
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRFZ1
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007679
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EHP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004639
Bombyx mori
Silkmoth
Bmor\BGIBMGA005935
Danaus plexippus
Monarch butterfly
Dple\DPOGS214208-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212368-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010187
Heliconius melpomene
Postman butterfly
Hmel\HMEL006805
Apis florea
Little honeybee
Aflo\3134249748
Apis florea
Little honeybee
Aflo\2162518388
Apis mellifera
Western honey bee
Amel\fz
Apis mellifera
Western honey bee
Amel\GB53589
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11697
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19278
Bombus terrestris
Buff-tailed bumblebee
Bter\15204088
Bombus terrestris
Buff-tailed bumblebee
Bter\15213945
Linepithema humile
Argentine ant
Lhum\LH21660
Linepithema humile
Argentine ant
Lhum\LH22279
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0016cc
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0002cc
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008241
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG030435
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08262
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05088
Tribolium castaneum
Red flour beetle
Tcas\Fz
Tribolium castaneum
Red flour beetle
Tcas\Fz2
Pediculus humanus
Human body louse
Phum\PHUM188130
Pediculus humanus
Human body louse
Phum\PHUM074510
Rhodnius prolixus
Kissing bug
Rpro\RPRC000842
Rhodnius prolixus
Kissing bug
Rpro\RPRC004621
Cimex lectularius
Bed bug
Clec\CLEC025149
Cimex lectularius
Bed bug
Clec\CLEC013254
Cimex lectularius
Bed bug
Clec\CLEC013254-PB
Cimex lectularius
Bed bug
Clec\CLEC013254-PC
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007768
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003976
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17750
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13395
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EGU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014833
Strigamia maritima
European centipede
Smar\SMAR012389
Ixodes scapularis
Black-legged tick
Isca\ISCW003177
Ixodes scapularis
Black-legged tick
Isca\ISCW004077
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61394.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63933.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g02450
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g01770
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g00140
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g01850
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_346805
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347539
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N5M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Frizz
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Frizz4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Frizz9/10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Frizz5/8
Ciona intestinalis
Vase tunicate
Cint\LOC100180303
Ciona intestinalis
Vase tunicate
Cint\cifrz
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002422
Ciona intestinalis
Vase tunicate
Cint\LOC100180069
Ciona intestinalis
Vase tunicate
Cint\sfrp3/4-b
Ciona intestinalis
Vase tunicate
Cint\LOC778717
Ciona intestinalis
Vase tunicate
Cint\fz3/6
Gallus gallus
Domestic chicken
Ggal\FZD10
Gallus gallus
Domestic chicken
Ggal\FZD7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008433
Gallus gallus
Domestic chicken
Ggal\FZD1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028487
Gallus gallus
Domestic chicken
Ggal\FZD3
Gallus gallus
Domestic chicken
Ggal\FZD4
Gallus gallus
Domestic chicken
Ggal\FZD6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
fz2
4 of 10
smo
4 of 10
fz4
3 of 10
fz3
2 of 10
CG1632
1 of 10
Corin
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    fzJB
    exacerbates  acute myeloid leukemia
    modeled by Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa
    (Sinenko et al., 2010)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FZD1; frizzled class receptor 1
    13 of 15
    603408
        FZD7; frizzled class receptor 7
        13 of 15
        603410
             
            FZD2; frizzled class receptor 2
            11 of 15
            600667
            FZD3; frizzled class receptor 3
            4 of 15
            606143
                FZD6; frizzled class receptor 6
                4 of 15
                603409
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                fz - ATP6AP2
                anti tag coimmunoprecipitation, anti tag western blot
                (Buechling et al., 2010)
                fz - Appl
                anti tag coimmunoprecipitation, anti tag western blot
                (Soldano et al., 2013)
                fz - Nhe2
                anti tag coimmunoprecipitation, anti tag western blot
                (Simons et al., 2009)
                fz - Patj
                anti tag coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography
                (Djiane et al., 2005)
                fz - Rab5
                pull down, anti tag western blot
                (Lin and Katanaev, 2013)
                fz - Vang
                inferred by author, affinity technology, tag visualisation by alkaline phosphatase activity, pull down, western blot
                (Wu and Mlodzik, 2008)
                fz - Wnt2
                affinity technology, enzyme linked immunosorbent assay, inferred by author
                (Wu and Nusse, 2002)
                fz - Wnt4
                affinity technology, enzyme linked immunosorbent assay, inferred by author
                (Wu and Nusse, 2002)
                fz - aPKC
                anti tag coimmunoprecipitation, western blot
                (Djiane et al., 2005)
                fz - baz
                anti tag coimmunoprecipitation, anti tag western blot, western blot
                (Banerjee et al., 2017, Djiane et al., 2005)
                fz - dsh
                two hybrid
                (Wong et al., 2003)
                fz - fw
                anti tag coimmunoprecipitation, anti tag western blot
                (Chin and Mlodzik, 2013)
                fz - meru
                anti tag coimmunoprecipitation, anti tag western blot
                (Banerjee et al., 2017)
                fz - mop
                anti bait coimmunoprecipitation, western blot
                (Pradhan-Sundd and Verheyen, 2015)
                fz - otk
                anti tag coimmunoprecipitation, anti tag western blot
                (Linnemannstöns et al., 2014)
                fz - otk2
                anti tag coimmunoprecipitation, anti tag western blot
                (Linnemannstöns et al., 2014)
                fz - stan
                anti tag coimmunoprecipitation, western blot, anti tag western blot
                (Chen et al., 2008)
                fz - wg
                affinity technology, enzyme linked immunosorbent assay, inferred by author, fluorescence microscopy
                (Mulligan et al., 2012, Wu and Nusse, 2002, Bhanot et al., 1996)
                RNA-protein
                Physical Interaction
                Assay
                References
                fz - B52
                electrophoretic mobility shift assay, autoradiography, systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing
                (Kim et al., 2003)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                fz
                enhanceable
                aos
                (Strutt and Strutt, 2003)
                fz
                enhanceable
                arm
                (Zhang and Carthew, 1998)
                fz2|fz
                suppressible
                arm
                (Chen and Struhl, 1999)
                fz
                suppressible
                ATP6AP2
                (Buechling et al., 2010, Hermle et al., 2010)
                fz
                enhanceable
                ATP6AP2
                (Hermle et al., 2010)
                fz
                enhanceable
                bdg
                (Rawls et al., 2007)
                fz
                suppressible
                bsk
                (Strutt et al., 1997)
                fz
                suppressible
                ck
                (Winter et al., 2001)
                fz
                enhanceable
                dco
                (Klein et al., 2006, Strutt et al., 2006)
                fz
                suppressible
                dco
                (Klein et al., 2006)
                fz
                suppressible
                dgo
                (Wu et al., 2008)
                fz
                enhanceable
                dgo
                (Wu et al., 2008)
                fz
                enhanceable
                Dl
                (Fanto and Mlodzik, 1999)
                fz
                enhanceable
                drl
                (Harris and Beckendorf, 2007)
                fz
                enhanceable
                ds
                (Adler et al., 1998)
                fz
                enhanceable
                dsh
                (Strutt et al., 2006, Wu et al., 2004, Strutt and Strutt, 2003, Lee and Adler, 2002, Zhang and Carthew, 1998)
                fz
                suppressible
                dsh
                (Wu et al., 2004, Lee and Adler, 2002, Winter et al., 2001, Strutt et al., 1997)
                fz
                enhanceable
                ed
                (Fetting et al., 2009)
                fz
                suppressible
                Egfr
                (Weber et al., 2008)
                fz
                enhanceable
                ft
                (Ma et al., 2003)
                fz
                suppressible
                ft
                (Yang et al., 2002)
                fz
                suppressible
                fw
                (Chin and Mlodzik, 2013)
                fz
                suppressible
                fy
                (Lee and Adler, 2002)
                fz
                suppressible
                fz2
                (Zhang and Carthew, 1998)
                fz
                suppressible
                fz::fz2
                (Wu et al., 2004, Strapps and Tomlinson, 2001, Rulifson et al., 2000)
                fz
                enhanceable
                grh
                (Lee and Adler, 2004)
                fz
                enhanceable
                Gαo
                (Katanaev et al., 2005)
                fz
                suppressible
                in
                (Lee and Adler, 2002)
                fz
                enhanceable
                in
                (Lee and Adler, 2002)
                fz
                suppressible
                Jra
                (Weber et al., 2000)
                fz
                suppressible
                kay
                (Ciapponi et al., 2001)
                fz
                suppressible
                mwh
                (Lee and Adler, 2002)
                fz
                enhanceable
                N
                (Fanto and Mlodzik, 1999)
                fz
                suppressible
                Nhe2
                (Simons et al., 2009)
                fz
                suppressible
                nkd
                (Rousset et al., 2001)
                fz
                enhanceable
                numb
                (Bellaiche et al., 2001)
                fz
                enhanceable
                pk
                (Lawrence et al., 2004, Adler et al., 2000)
                fz
                enhanceable
                Rab23
                (Pataki et al., 2010)
                fz
                enhanceable
                Ras85D
                (Strutt and Strutt, 2003)
                fz
                suppressible
                Rho1
                (Winter et al., 2001, Strutt et al., 1997)
                fz
                suppressible
                Rok
                (Winter et al., 2001)
                fz
                suppressible
                sgg
                (Zhang and Carthew, 1998)
                fz
                suppressible
                sqh
                (Winter et al., 2001)
                fz
                suppressible
                stan
                (Lawrence et al., 2004, Chae et al., 1999)
                fz
                enhanceable
                stan
                (Chae et al., 1999)
                fz
                enhanceable
                sty
                (Strutt and Strutt, 2003)
                fz
                enhanceable
                tow
                (Chung et al., 2007)
                fz
                suppressible
                tow
                (Chung et al., 2007)
                fz
                suppressible
                Vang
                (Lawrence et al., 2004, Taylor et al., 1998)
                fz
                enhanceable
                Vang
                (Taylor et al., 1998)
                fz
                suppressible
                wg
                (Axelrod et al., 1998, Zhang and Carthew, 1998)
                fz
                suppressible
                Wnt4
                (Lim et al., 2005)
                fz
                enhanceable
                Wnt5
                (Srahna et al., 2006)
                fz
                enhanceable
                zip
                (Winter et al., 2001)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                DAAM
                enhanceable
                fz
                (Gombos et al., 2015)
                dco
                enhanceable
                fz
                (Klein et al., 2006)
                dgo
                suppressible
                fz
                (Jenny et al., 2005)
                drl
                enhanceable
                fz
                (Harris and Beckendorf, 2007)
                ds
                suppressible
                fz
                (Adler et al., 1998)
                dsh
                suppressible
                fz
                (Tree et al., 2002)
                Egfr
                suppressible
                fz
                (Weber et al., 2008)
                fw
                suppressible
                fz
                (Chin and Mlodzik, 2013)
                fy
                enhanceable
                fz
                (Lee and Adler, 2002)
                fy|in
                suppressible
                fz
                (Wang et al., 2014)
                fz2
                suppressible
                fz
                (Zhang and Carthew, 1998)
                fz2
                enhanceable
                fz
                (Chen and Struhl, 1999)
                grh
                enhanceable
                fz
                (Lee and Adler, 2004)
                Gαo
                enhanceable
                fz
                (Katanaev et al., 2005)
                Gαo
                suppressible
                fz
                (Katanaev and Tomlinson, 2006, Katanaev et al., 2005)
                Hrs
                suppressible
                fz
                (Seto and Bellen, 2006)
                in
                suppressible
                fz
                (Lee and Adler, 2002)
                in
                enhanceable
                fz
                (Lee and Adler, 2002)
                kermit
                enhanceable
                fz
                (Lin and Katanaev, 2013)
                meru
                enhanceable
                fz
                (Banerjee et al., 2017)
                pk
                suppressible
                fz
                (Jenny et al., 2003)
                pk
                enhanceable
                fz
                (Jenny et al., 2003)
                pwn|stan
                suppressible
                fz
                (Lawrence et al., 2004)
                Rab23
                enhanceable
                fz
                (Pataki et al., 2010)
                Rho1
                suppressible
                fz
                (Bastock and Strutt, 2007)
                sha
                enhanceable
                fz
                (Ren et al., 2006)
                stan
                suppressible
                fz
                (Lawrence et al., 2004)
                Vang
                suppressible
                fz
                (Wu and Mlodzik, 2008, Lawrence et al., 2004, Taylor et al., 1998)
                Vang
                enhanceable
                fz
                (Taylor et al., 1998)
                wg
                suppressible
                fz
                (Moline et al., 2000)
                Wnt5
                enhanceable
                fz
                (Srahna et al., 2006)
                zip
                enhanceable
                fz
                (Franke et al., 2010)
                External Data
                Subunit Structure (UniProtKB)
                Interacts with ATP6AP2.
                (UniProt, P18537 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Wnt-TCF Signaling Pathway Core Components -
                The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
                Metabolic Pathways
                External Data
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3L
                Recombination map
                3-42
                Cytogenetic map
                70D4-70D5
                Sequence location
                3L:14,274,343..14,368,639 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                70D4-70D5
                Limits computationally determined from genome sequence between P{PZ}l(3)70Da02402&P{PZ}btl00208 and P{PZ}Mpcp00564
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                70D4-70D7
                (determined by in situ hybridisation)
                (Adler et al., 1990, Vinson et al., 1989)
                Experimentally Determined Recombination Data
                Location
                3-42
                (FlyBase, 2016)
                3-36.0
                (Comeron et al., 2012)
                2-42
                (Fernandez Gianotti, 1952)
                3-41.7
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (32)
                Genomic Clones (43)
                cDNA Clones (147)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                monoclonal, polyclonal
                (Park et al., 1994)
                Commercially Available Antibodies
                 
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for identity of: fz CG3646
                (Bayraktaroglu, 1999.11)
                Source for database merge of
                Source for merge of: fz CG3646 CG17697
                (Bayraktaroglu, 2000.4.17)
                Additional comments
                Most alleles fit into a hypomorphic to amorphic series with many hemizygotes displaying a more severe phenotype than homozygotes.
                Other Comments
                Mutations in fz influence the arrangement of ommatidia at the micro-scale but have no effect on the ommatidium nano-scale structure.
                (Kryuchkov et al., 2011)
                fz is required for normal salivary gland migration in the embryo. It is required in the second phase of salivary gland migration, as the gland moves posteriorly within the embryo.
                (Harris and Beckendorf, 2007)
                Clonal analysis indicates that the ds/ft system and the stan/fz system act independently to confer planar cell polarity in the adult abdomen; each system confers and propagates polarity and can do so in the absence of the other.
                (Casal et al., 2006)
                dsRNA made from templates generated with primers directed against this gene.
                (Klein et al., 2006)
                fz is transported to the distal sides of developing wing blade cells during pupal stages by transport in microtubules associated endosomes.
                (Shimada et al., 2006)
                Molecular analyses suggest that the cysteine-rich domain of fz recruits wg, and bound wg interacts with the membrane portion of the receptor to initiate signalling. RNAi knockdown experiments show that fz and wg also require the receptor Arr1 to initiate arm signalling.
                (Povelones and Nusse, 2005)
                The wg morphogen gradient appears to be established by the cooperative action of fz and Heparan Sulfate Proteoglycan receptors.
                (Baeg et al., 2004)
                Vang acts together with fz and stan to mediate apicolateral recruitment of planar polarity proteins including dsh and pk.
                (Bastock et al., 2003)
                The Vang/pk complex appears to modulate fz/dsh activity, resulting in a symmetry-breaking step during polarity signalling.
                (Jenny et al., 2003)
                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                (Kiger et al., 2003)
                The fz feedback loop, acting to propagate polarity from cell to cell, is sufficient to align planar polarity of cells in the wing.
                (Ma et al., 2003)
                in and fy are needed in cells receiving and responding to a fz dependent intercellular signal. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy.
                (Lee and Adler, 2002)
                Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. In the wing as in the abdomen in and fy are epistatic to fz as double mutants resemble in and fy and not fz. fz and Vang show complementary domineering nonautonomy in the wing and abdomen. The domineering nonautonomy in the abdomen of fz clones is not blocked by cells also being mutant for in. In the eye fz is epistatic to in and fy. In terms of the wing eversion phenotype of fz, in and fy appear to be epistatic to fz.
                (Lee and Adler, 2002)
                fz play an important role in the regulation planar polarity in the compound eye.
                (Yang et al., 2002)
                fz participates in the pIIa vs pIIb fate decision in the external sensory organ lineage.
                (Bellaiche et al., 2001)
                Area matching Drosophila Frizzled gene Acc. No. X54648.
                (Davies, 2001.3.15)
                the asymmetric localisation of fz in adult wing cells may be an instructive cue in the determination of cell polarity.
                (Strutt, 2001)
                fz and fz2 function as redundant receptors for wg during embryonic development.
                (Bhanot et al., 1999)
                Mutant embryos lacking maternal fz, zygotic fz and zygotic fz2 show defects in the epidermis, CNS, heart and midgut that are indistinguishable from the defects observed for wg mutants.
                (Bhanot et al., 1999)
                fz and fz2 are required during embryogenesis to maintain epidermal en and wg expression.
                (Bhanot et al., 1999)
                fz and fz2 are functionally redundant and act as the primary receptors for wg protein.
                (Chen and Struhl, 1999)
                wg signal transduction is abolished in virtually all cells lacking both fz and fz2 in embryos as well as in imaginal discs.
                (Chen and Struhl, 1999)
                fz appears to function in the wg pathway to pattern sensory organs.
                (Lu et al., 1999)
                Wing cells appear acquire proximo-distal polarity by way of the fz-dependant boundary localisation of stan.
                (Usui et al., 1999)
                Mutations in ds cause a tissue polarity phenotype in the wing by altering the direction of fz signaling.
                (Adler et al., 1998)
                fz and fz2 play a partially redundant role in wg signalling during neurogenesis.
                (Bhat, 1998)
                dsh functions in both fz and fz2 signalling, but distinct dsh protein domains feature in the two pathways.
                (Boutros et al., 1998)
                fz-mediated signalling provides polarity information to pI, specifying the orientation of mitotic spindles. The orientations of the pIIa and pIIb divisions are independent of fz signalling and are instead defined by the axis of the previous pI division.
                (Gho and Schweisguth, 1998)
                fz and fz2 function redundantly, downstream of wg and upstream of sgg, in the wg signalling pathway in the establishment of segment polarity in the embryo.
                (Kennerdell and Carthew, 1998)
                The Vang gene product is essential for fz signalling.
                (Taylor et al., 1998)
                fz2 and not fz acts in the wg signalling pathway for wing margin development.
                (Zhang and Carthew, 1998)
                A single dominant negative form of fz or fz2 can block more than one type of Wnt signalling pathway implying that truncated proteins of the Fz family lose some aspect of signaling specificity.
                (Zhang and Carthew, 1998)
                Cells can assess the level of fz protein on neighbouring cells and use this as a source of polarity information.
                (Adler et al., 1997)
                Mutants do not exhibit defects in the denticle belt of hairs of the larvae.
                (Dickinson and Thatcher, 1997)
                Genetic interactions indicate that Rho1 has a role in signalling mediated by fz.
                (Strutt et al., 1997)
                Planar polarity phenotypes of loss of function and overexpression of fz in the developing eye is studied, the phenotype is almost identical to loss of function or overexpression of dsh, or overexpression of sgg. Overexpression of fz in the developing eye has a potent polarizing effect on the retinal epithelium.
                (Tomlinson et al., 1997)
                Cell nonautonomous fz alleles are associated with mutations that alter amino acids in all regions of the encoded protein. The four cell autonomous mutations fall in a proline residue in the presumptive first cytoplasmic loop of the protein. Comparison of fz with Dvir\fz revealed that the protein is unusually well conserved: in the putative cytoplasmic domains the two proteins are identical.
                (Jones et al., 1996)
                dsh function is required for endogenous fz activity. fz activity is directly proportional to dsh gene dosage.
                (Krasnow et al., 1995)
                Loss of fz function affects the rotation and breaking of symmetry of photoreceptor cell preclusters. Clonal analysis reveals that fz acts non-autonomously. Mitotic clones affect the polarity of neighboring wild-type ommatidia distal, but not proximal to the equatorial midline, suggesting that fz might mediate a signal in the developing eye transmitted bidirectionally from the equator to the opposite poles.
                (Zheng and Carthew, 1995)
                The function of fz is required in the establishment of mirror-image symmetry about the equatorial midline in the compound eye.
                (Zheng and Carthew, 1995)
                Mutant phenotype suggests fz is required for the correct rotational direction, the precise 90o turn and the correct asymmetry arrangement of R3 and R4 cells. fz is not required for the synchronous movement of photoreceptor cells within individual clusters since photoreceptor cells in each fz mutant ommatidium still rotate as a unit. Mosaic analysis demonstrates fz has non-autonomous effects on eye development. Double mutant analysis suggests that nmo and fz functional synergistically in directing ommatidial rotation.
                (Zheng et al., 1995)
                A cold sensitive allele of fz has been isolated and study of the mutant argues that fz has a regulatory function in specifying where the prehair forms, but has no role in the actual morphogenesis of the prehair.
                (Adler et al., 1994)
                Comparisons between fz and in alleles reveals that at equivalent fractions of the wing showing abnormal polarity, in mutant wings have many fold more multiple hair cells than fz mutant wings.
                (Krasnow and Adler, 1994)
                The longer, more abundant form of the two mRNA variants transcribed from fz encodes both the cell autonomous and non-autonomous functions of fz that have been revealed in mosaic experiments.
                (Krasnow and Adler, 1994)
                Western blot analysis of fz protein accumulation in wing discs and pupal wings demonstrates fz is expressed in all regions of the epidermis before, during and after the fz cold sensitive period and prehair morphogenesis. fz function is not required for normal fz expression and mutations in other tissue polarity genes does not alter the amount or size of fz protein.
                (Park et al., 1994)
                fz protein is an integral membrane protein with an odd number of transmembrane domains. Immunostaining of pupal wings reveals that the fz protein is evenly distributed across the wing and concentrates in the apical region of the pupal wing cells.
                (Park et al., 1994)
                Two similar proteins identified in rat.
                (Chan et al., 1992)
                Cloning and characterisation of the fz locus has shown that this locus is very large (over 90kb) and probably encodes an integral membrane protein.
                (Adler et al., 1990)
                Hairs on thorax directed irregularly toward midline. Thoracic bristles also inturned and often wavy. Postverticals may turn outward. Hairs on wing edge and feet nearly erect; trichomes on wings of flies carrying weaker alleles tend to form swirls rather than lying parallel to one another and pointing distally; stronger alleles can cause random orientation of trichomes. Polarity of chaetae deranged in characteristic ways on wings, notum, halteres, legs, tergites and sternites; fz M+ clones in M/+ wings cause derangement of polarity in M/+ cells surrounding clone (Gubb and Garcia-Bellido, 1982). In a wild-type background clones of wing cells homozygous for fz alleles that cause eye roughening, but not of those without effect on eye texture, cause adjacent normal trichomes in regions distal, anterior and posterior, but not proximal to the clone, to orient toward the clone rather than distally as they normally do; no effect on trichomes on opposite surface of the wing (Vinson and Adler, 1987). Wing may be reduced. A low level of doubling of trichomes and splitting of chaetae observed. Sex combs may be irregular. Most alleles cause eyes to be rough Extra leg joints tend to form as mirror-image duplications proximal to the normal joints on tarsal segments one to four. Also polarities of bristles, hairs, and bracts on legs abnormal (Held, Duarte and Derakhshanian, 1986).
                Origin and Etymology
                Discoverer
                Bridges, 18th Feb. 1938.
                Etymology
                Identification
                External Crossreferences and Linkouts ( 89 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (24)
                Reported As
                Symbol Synonym
                CG17697
                (Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Carrera et al., 2008, Holloway et al., 2008, Ni et al., 2008)
                CG3646
                (Norga et al., 2003)
                DFZ1
                (Rehn et al., 1998)
                DFz
                (Hermle et al., 2010, Wehrli et al., 2002, Wehrli et al., 2001)
                DFz1
                (He, 2003, Eroglu et al., 2002)
                Dfz
                (Huang and Klein, 2004)
                Dfz1
                (Bovolenta et al., 2006, Schweizer and Varmus, 2003, Yanagawa et al., 1998, Perrimon, 1996, Wang et al., 1996)
                Dm Fz1
                (Konikoff et al., 2010)
                FZ
                (Bayly and Axelrod, 2011, Dawes-Hoang and Wieschaus, 2001, Tree et al., 2000)
                FZ1
                (Ferrandon, 2013)
                Frizzled
                (Schenkelaars et al., 2016)
                Frz
                (Nagaraj and Banerjee, 2009)
                Fz
                (Bonello and Peifer, 2019, Strutt et al., 2019, Humphries and Mlodzik, 2018, Lippert et al., 2017, Carvajal-Gonzalez et al., 2016, Carvajal-Gonzalez et al., 2016, Chen et al., 2016, Yadav et al., 2016, Bouleau and Tricoire, 2015, Galic and Matis, 2015, Schweisguth, 2015, Jenny and Basler, 2014, Rousselle et al., 2014, Bejsovec, 2013, Bischof et al., 2013, Ezan and Montcouquiol, 2013, Fischer et al., 2013, Lawrence and Casal, 2013, Lu and Johnston, 2013, Matis and Axelrod, 2013, Mbodj et al., 2013, Serysheva et al., 2013, Serysheva et al., 2013, Shimmi and Newfeld, 2013, Zuo et al., 2013, Mouri et al., 2012, Mulligan et al., 2012, Muñoz-Soriano et al., 2012, Pirooznia et al., 2012, Singh and Mlodzik, 2012, Singh and Mlodzik, 2012, Tan et al., 2012, Weber et al., 2012, Buechling et al., 2011, Erickson, 2011, Hermle et al., 2011, Yanfeng et al., 2011, Buechling et al., 2010, Djiane and Mlodzik, 2010, Hermle et al., 2010, McNeill, 2010, Mottola et al., 2010, Ségalen et al., 2010, Kopein and Katanaev, 2009, Jenny et al., 2008, Ma et al., 2008, Sánchez et al., 2008, Segalen et al., 2007, Walthall et al., 2007, Wu and Mlodzik, 2007, Blair et al., 2006, Chin and Yeston, 2006, Halbleib and Nelson, 2006, He and Axelrod, 2006, Humbert et al., 2006, Jankovics and Brunner, 2006, Klein et al., 2006, Quaiser, 2006, Torban et al., 2004, Baeg et al., 2003, Kockel et al., 2001, Rulifson et al., 2000, Wu et al., 2000, Kudoh, 1999)
                Fz1
                (Jiang et al., 2016, Djiane and Mlodzik, 2010, Chaudhary and Strutt, 2007, Wu et al., 2004, Johnson et al., 2000, Perrimon and Nusse, 1998)
                dFz
                (Soldano et al., 2013)
                frizzled
                (Furman and Bukharina, 2011)
                frz
                (Ayroles et al., 2009, Gubb et al., 1999, Novak and Dedhar, 1999)
                fz
                (Meltzer et al., 2019, Steinhauer et al., 2019, Strutt et al., 2019, Thuveson et al., 2019, Billmann et al., 2018, Garrido-Jimenez et al., 2018, Katanaev et al., 2018, Kim et al., 2018, Li-Kroeger et al., 2018, Ripp et al., 2018, Banerjee et al., 2017, Ewen-Campen et al., 2017, Tian et al., 2017, Wang et al., 2017, Aigouy and Le Bivic, 2016, Carbone et al., 2016, Carvajal-Gonzalez et al., 2016, Cate et al., 2016, Clandinin and Owens, 2016-, Dollar et al., 2016, Duun Rohde et al., 2016, Gene Disruption Project members, 2016-, Gomez et al., 2016, Kelly et al., 2016, Kim et al., 2016, Kockel et al., 2016, Morimoto et al., 2016, Mottier-Pavie et al., 2016, Strutt et al., 2016, Vega-Macaya et al., 2016, Wang et al., 2016, Besson et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Gombos et al., 2015, Hsu et al., 2015, Kallsen et al., 2015, Morozova et al., 2015, Yang and Mlodzik, 2015, Yasunaga et al., 2015, Ashwal-Fluss et al., 2014, Kerr et al., 2014, Toshima et al., 2014, Wang et al., 2014, Abley et al., 2013, Brown et al., 2013, Chin and Mlodzik, 2013, Harbison et al., 2013, Hazelwood and Hancock, 2013, Hermle et al., 2013, Jin et al., 2013, Lawrence and Casal, 2013, Lin and Katanaev, 2013, Marcinkevicius and Zallen, 2013, Pancratov et al., 2013, Schertel et al., 2013, Sharma and McNeill, 2013, Shen et al., 2013, Strutt et al., 2013, Webber et al., 2013, Wu et al., 2013, Brittle et al., 2012, Capilla et al., 2012, Gault et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kuroda et al., 2012, Muñoz-Soriano et al., 2012, Strutt et al., 2012, Tan et al., 2012, Weber et al., 2012, Carreira et al., 2011, Cernilogar et al., 2011, Cho and Fischer, 2011, Cho et al., 2011, Goodrich and Strutt, 2011, Jungreis et al., 2011, Kryuchkov et al., 2011, Matsubara et al., 2011, Mirkovic et al., 2011, Olguín et al., 2011, Olguín et al., 2011, Shimizu et al., 2011, Toku et al., 2011, Vincent et al., 2011, Zhu, 2011, Cordero and Cagan, 2010, Franke et al., 2010, Harumoto et al., 2010, Hermle et al., 2010, Ho et al., 2010, Li et al., 2010, Lu et al., 2010, Pataki et al., 2010, Repiso et al., 2010, Sinenko et al., 2010, Singh et al., 2010, Ayroles et al., 2009, Blanco et al., 2009, Burak and Shraiman, 2009, Chung et al., 2009, Fetting et al., 2009, Gomes et al., 2009, Hazelett et al., 2009, Piddini and Vincent, 2009, Seugnet et al., 2009, Simons et al., 2009, Sinenko et al., 2009, Steinel and Whitington, 2009, Yan et al., 2009, Zhu, 2009, Carrera et al., 2008, Chen et al., 2008, Doyle et al., 2008, Fabre et al., 2008, Fiehler and Wolff, 2008, Holloway et al., 2008, Lin et al., 2008, Strutt and Strutt, 2008, Strutt and Warrington, 2008, Todi et al., 2008, Weber et al., 2008, Wu and Mlodzik, 2008, Wu et al., 2008, Yan et al., 2008, Aerts et al., 2007, Bastock and Strutt, 2007, Beltran et al., 2007, Bhat, 2007, Chung et al., 2007, DasGupta et al., 2007, Fiehler and Wolff, 2007, Grillenzoni et al., 2007, Harris and Beckendorf, 2007, Kankel et al., 2007, Lawrence et al., 2007, Madder and Strutt, 2007, Rawls et al., 2007, Silver et al., 2007, Strutt and Strutt, 2007, Tyler et al., 2007, Zeitlinger et al., 2007, Bartscherer et al., 2006, Casal et al., 2006, del Alamo and Mlodzik, 2006, Edwards et al., 2006, Gordon and Nusse, 2006, Jaiswal et al., 2006, Le Garrec et al., 2006, Ma et al., 2006, Mirkovic and Mlodzik, 2006, Price et al., 2006, Ren et al., 2006, Rives et al., 2006, Sato et al., 2006, Seto and Bellen, 2006, Shimada et al., 2006, Strutt et al., 2006, Walters et al., 2006, Cabernard and Affolter, 2005, Classen et al., 2005, DasGupta et al., 2005, David et al., 2005, Furlong, 2005, Jenny et al., 2005, Lim et al., 2005, Lipatov et al., 2005, Strutt and Strutt, 2005, Fanto and McNeill, 2004, Huang and Klein, 2004, Lawrence et al., 2004, He and Adler, 2002, Strutt, 2001, Winter et al., 2001, Goo et al., 1999)
                fz1
                (Djiane et al., 2005, Anonymous, 2004, Lum et al., 2003)
                fz1
                (Baena-Lopez and Garcia-Bellido, 2006)
                Name Synonyms
                Frizzled
                (Ahmed-de-Prado and Baonza, 2018, Saito et al., 2018, Ahmad, 2017, Baker, 2017, Richardson and Portela, 2017, Carvajal-Gonzalez et al., 2016, Cate et al., 2016, Shilo, 2016, Veeman and McDonald, 2016, Wang et al., 2016, Pradhan-Sundd and Verheyen, 2015, Jenny and Basler, 2014, Linnemannstöns et al., 2014, Sadeqzadeh et al., 2014, Chin and Mlodzik, 2013, Ezan and Montcouquiol, 2013, Giannios and Tsitilou, 2013, Hazelwood and Hancock, 2013, Sharma and McNeill, 2013, Zhang et al., 2013, Gault et al., 2012, Koles and Budnik, 2012, Pirooznia et al., 2012, Singh and Mlodzik, 2012, Singh and Mlodzik, 2012, Tan et al., 2012, Weber et al., 2012, Strutt et al., 2011, Hermle et al., 2010, Li et al., 2010, Mottola et al., 2010, Ségalen et al., 2010, Swaminathan et al., 2010, Blanco et al., 2009, Gomes et al., 2009, Kopein and Katanaev, 2009, Chen et al., 2008, Lin et al., 2008, Strutt and Strutt, 2008, Todi et al., 2008, Wu et al., 2008, Bhat, 2007, Coudreuse and Korswagen, 2007, Kerszberg and Wolpert, 2007, Lecuit and Le Goff, 2007, Strutt and Strutt, 2007, Tountas and Fortini, 2007, Walthall et al., 2007, Warrington and Strutt, 2007, Wu and Mlodzik, 2007, Anonymous, 2006, Blair et al., 2006, Djiane et al., 2006, Hariharan, 2006, Heeg-Truesdell, 2006, Price et al., 2006, Quaiser, 2006, Srahna et al., 2006, Stadeli, 2006, David et al., 2005, Lim et al., 2005, Marques, 2005, Voas and Rebay, 2004, Pandur et al., 2002, Dawes-Hoang and Wieschaus, 2001)
                Frizzled 1
                (Niehrs, 2012, Eroglu et al., 2002, Johnson et al., 2000)
                Frizzled1
                (Martinez Arias, 2005)
                frizzled
                (Waghmare and Page-McCaw, 2018, Mottier-Pavie et al., 2016, Yang and Mlodzik, 2015, Yasunaga et al., 2015, Faisal et al., 2014, Toshima et al., 2014, Abley et al., 2013, Bausek, 2013, Harbison et al., 2013, Lawrence and Casal, 2013, Erickson, 2011, Kryuchkov et al., 2011, Shimizu et al., 2011, Zhu, 2011, Franke et al., 2010, Lu et al., 2010, Pataki et al., 2010, Sinenko et al., 2010, Fetting et al., 2009, Curtis et al., 2007, Fiehler and Wolff, 2007, Harris and Beckendorf, 2007, Kankel et al., 2007, Lawrence et al., 2007, Silver et al., 2007, Zeitouni et al., 2007, Edwards et al., 2006, Le Garrec et al., 2006, Sambandan et al., 2006, Seto and Bellen, 2006, Burnette et al., 2005, Burnette et al., 2005, Leptin, 2005, Strutt, 2005, Strutt and Strutt, 2005, Fanto and McNeill, 2004, Huang and Klein, 2004, He and Adler, 2002, Lee and Adler, 2002, Winter et al., 2001)
                frizzled 1
                (Zahner et al., 2000)
                frizzled1
                (Baena-Lopez and Garcia-Bellido, 2006)
                Secondary FlyBase IDs
                • FBgn0036418
                • FBgn0036420
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (799)