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Gene Dmel\fz

General Information
Symbol	Dmel\fz	Species	D. melanogaster
Name	frizzled	Annotation symbol	CG17697
Feature type	protein_coding_gene	FlyBase ID	FBgn0001085
Gene Model Status	Current	Stock availability	37 publicly available
Also Known As	fz1, DFz1, frz, DFz
Genomic Location
Chromosome (arm)	3L	Recombination map	3-41.7
Cytogenetic map	70D4-70D5	Sequence location	3L:14,267,443..14,361,739 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene frizzled is referred to in FlyBase by the symbol Dmel\fz (CG17697, FBgn0001085). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-activated receptor activity. There is experimental evidence for 22 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; biological regulation; sensory organ development; establishment of planar polarity; post-embryonic organ morphogenesis; localization; ommatidial rotation; gland morphogenesis; imaginal disc-derived wing hair organization. 195 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; external compound sense organ; portion of tissue; integumentary specialisation; thoracic segment; appendage segment; peripheral nervous system; non-connected developing system. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Frizzled domain; Frizzled protein; Frizzled/secreted frizzled-related protein; GPCR, family 2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult ovary. Gene sequence location is 3L:14267443..14361739.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fz: frizzled fz: frizzled From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 85. Hairs on thorax directed irregularly toward midline. Thoracic bristles also inturned and often wavy. Postverticals may turn outward. Hairs on wing edge and feet nearly erect; trichomes on wings of flies carrying weaker alleles tend to form swirls rather than lying parallel to one another and pointing distally; stronger alleles can cause random orientation of trichomes. Polarity of chaetae deranged in characteristic ways on wings, notum, halteres, legs, tergites, and sternites; fz M+ clones in M/+ wings cause derangement of polarity in M/+ cells surrounding clone (Gubb and Garcia-Bellido, 1982, J. Embryol. Exp. Morphol. 68: 37-57). In a wild-type background clones of wing cells homozygous for fz alleles that cause eye roughening, but not of those without effect on eye texture, cause adjacent normal trichomes in regions distal, anterior, and posterior, but not proximal to the clone, to orient toward the clone rather than distally as they normally do; no effect on trichomes on opposite surface of the wing (Vinson and Adler, 1987, Nature 329: 549-51). Wing may be reduced. A low level of doubling of trichomes and splitting of chaetae observed. Sex combs may be irregular. Most alleles cause eyes to be rough. Two weak alleles, fz24 and fz34 and two neomorphic alleles, fz13 and fz20, have normal eye textures. Extra leg joints tend to form as mirror-image duplications proximal to the normal joints on tarsal segments one to four. Also polarities of bristles, hairs, and bracts on legs abnormal (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). RK2. fz13 A neomorphic allele causing severe disruption of trichome orientation in the costal wing cell, a region little affected by most alleles; phenotype of homozygote more severe than that of hemizygote. Also unlike other alleles, homozygous clones of fz13 cells in the wing do not affect orientation of trichomes in surrounding normal cells. A third notable feature of fz13 is that it is without effect on eye texture. fz20 Like fu13.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms gonad development regulation of transcription from RNA polymerase II promoter vasculature development embryo development PDZ domain binding neuron projection membrane brain development
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70D4-70D5   Limits computationally determined from genome sequence between P{PZ}l(3)70Da02402&P{PZ}btl00208 and P{PZ}Mpcp00564
Experimentally Determined Cytological Location
Cytogenetic map Notes References 70D4-70D7   (determined by in situ hybridisation)   (Adler et al., 1990) 70D4-70D7   (determined by in situ hybridisation)   (Vinson et al., 1989)
Experimentally Determined Recombination Data
Location	3-41.7   2-42 (Fernandez Gianotti, 1952)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 Stop-codon suppression (UAG) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697 Low-frequency RNA-Seq exon junction(s) not annotated. Transposon inserted in intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fz-RA FBtr0075743  NM_080073   3817   581 fz-RB FBtr0075742  NM_168587   3756   415 fz-RC FBtr0330102  NM_001274907   3817   612
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Vinson et al., 1989) 4.0, >4.0 (northern blot) (Adler et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fz-PA   FBpp0075485   64.8   581   8.22     NP_524812   AAF49746 fz-PB   FBpp0075484   46.1   415   7.78     NP_729970   AAN11810 fz-PC   FBpp0303135   68.0   612   7.95     NP_001261836   AGB94529
Additional Polypeptide Data & Comments
Reported size (kDa)	581 (aa) (Vinson et al., 1989) 581, 415 (aa) (Adler et al., 1990) 62, 60 (kD observed); 62 (kD predicted) (Park et al., 1994) 62, 60 (kD observed) (Park et al., 1994) 60, 42 (kD observed) (Krasnow and Adler, 1994)
Comments	Experiments with heat shock driven transgenes demonstrate that only the longer 581aa form of the fz protein shows any activity and rescues fz mutations. Overexpression results in two distinct tissue polarity phenotypes. (Krasnow and Adler, 1994) Experiments with heat shock driven transgenes demonstrate that the shorter 415aa form of the fz protein is unable to rescue fz mutations. No endogenous protein of this size was detected. (Krasnow and Adler, 1994) The fz protein contains and odd number of transmembrane domains and is glycosylated. (Park et al., 1994) One of a couple of protein products. (FlyBase, 1992-, FlyBase, 1992-) The 415aa fz protein is essentially a carboxy-terminal truncated class I fz protein. It contains the seven transmembrane domains and is also likely to be an integral membrane protein. (Adler et al., 1990) The fz protein has 7 putative transmembrane domains. (Vinson et al., 1989)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GPCR, family 2-like (IPR017981) Frizzled protein (IPR000539) Frizzled/secreted frizzled-related protein (IPR015526) Frizzled domain (IPR020067)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA951534   AA952093   AE014296 AAF49746   AE014296 AAN11810   AE014296 AGB94529   AI519380   AI532227   AI543818   AW943116   AX093877   AY051808 AAK93232   AZ933376   BG633414   BG639627   BI162105   BI164092   BI165032   BI165961   BI169842   BI172180   BI172848   BI173241   BI213065   BI213273   BI214739   BI215177   BI215598   BI216139   BI216461   BI231985   BI232524   BI232715   BI234662   BI234687   BI236646   BI237040   BI239419   BI239546   BI240992   BI241147   BI242073   BI242294   BI242837   BI357809   BI362491   BI362497   BI363808   BI364569   BI365372   BI366072   BI366095   BI368221   BI372060   BI372087   BI374207   BI374223   BI374823   BI375307   BI376061   BI481826   BI482038   BI483689   BI483953   BI578129   BI578382   BI578720   BI580334   BI584411   BI607981   BI610718   BI617419   BI620774   BI623646   BI627891   BP545139   BP553471   CL868592   CO185321   CO187068   CO188273   CO190760   CO190911   CO262712   CO262903   CO263511   CO264536   CO265362   CO266290   CO271711   CO278229   CO285531   CO288792   CO295053   CO298467   CO299177   CO301673   CO303174   CO303696   CO311345   CO314911   CO327622   CO332090   CO335547   CO337507   CO337803   CO338534   CO341281   CZ468672   CZ470087   CZ472260   CZ478448   CZ479142   CZ479504   CZ479505   CZ479546   CZ481175   CZ481176   CZ483452   CZ489475   CZ489476   CZ489683   CZ490629   CZ490630   EC058703   EC061332   EC067757   EC070833   EC071630   EC074254   EC074774   EC074799   EC075182   EC077040   EC082007   EC084651   EC084671   EC088401   EC088529   EC088530   EC194391   EC195603   EC196818   EC198482   EC202652   EC210176   EC213598   EC221491   EC224510   EC228145   EC228801   EC232107   EC240178   EC240447   EC240863   EC242543   EC242757   EC254546   EC258261   EC261563   EC264412   EC267045   EV582678   GH941133   GH941363   GH943413   GH944953   GH945272   GH948712   GH948794   GH949173   GH949750   GH950212   GH951598   GH951806   GH955765   GH963017   GH963688   GH970528   GH970783   GH970946   GH971979   GH972643   GH973688   GH975611   GH978097   GH978734   GH979423   GH981187   GH982030   GH983434   GH983701   X54646 CAA38458   X54647 CAA38459   X54648 CAA38460   X54648 CAA38461   X54649 CAA38460   X54649 CAA38461   X54650 CAA38460   X54650 CAA38461   X54651 CAA38460   X54652 CAA38461
UniProtKB/Swiss-Prot	P18537
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference larval stage   eye-antennal disc   (Zheng et al., 1995) morphogenetic furrow   (Zheng et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Adler et al., 1990) embryonic stage -- pupal stage     (Adler et al., 1990) pupal stage     (Vinson et al., 1989, Adler et al., 1990) adult stage | female     (Adler et al., 1990) oogenesis & adult stage | female   ovary   (Adler et al., 1990) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Park et al., 1994) third instar larval stage   embryonic/larval proventriculus   (Park et al., 1994) embryonic/larval brain   (Park et al., 1994) imaginal disc   (Park et al., 1994) ventral nerve cord   (Park et al., 1994) pupal stage   wing   (Park et al., 1994) central nervous system   (Park et al., 1994) epidermis   (Park et al., 1994) oogenesis & adult stage | female   ovary   (Park et al., 1994)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference pupal stage   wing   (Park et al., 1994) western blot Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   imaginal disc   (Park et al., 1994) embryonic/larval central nervous system   (Park et al., 1994) wing disc   (Park et al., 1994)
Additional Descriptive Data
	fz protein is detected at low abundance in samples from wing discs, other imaginal discs, and CNS and appears as a doublet. (Park et al., 1994, Park et al., 1994) fz protein is detected at low abundance in all regions of the pupal wing. (Park et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell cortex inferred from direct assay (Strutt, 2001) colocalizes_with endosome inferred from direct assay (Shimada et al., 2006) plasma membrane inferred from direct assay (Park et al., 1994, Povelones and Nusse, 2005)
Expression Deduced from Reporters
Reporter: P{lacW}fj9-II Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc | restricted   (Villano and Katz, 1995) larval outer optic anlage   (Villano and Katz, 1995) eye-antennal disc | restricted   (Villano and Katz, 1995) ventral thoracic disc | restricted   (Villano and Katz, 1995) pupal stage   tibia   (Villano and Katz, 1995) ventral thoracic disc | restricted   (Villano and Katz, 1995) adult stage   wing   (Villano and Katz, 1995) antenna   (Villano and Katz, 1995) leg   (Villano and Katz, 1995)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    6 central nervous system, pupae P8    9 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    18 ovary, mated 4-day female    9 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr    27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr  (27) embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr    27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr    27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr    27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr  27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr    27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    20 embryo 04-06hr    18 embryo 06-08hr    20 embryo 08-10hr    27 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    9 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    11 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    2 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    14 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    17 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    3 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001085 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17697-RA;CG17697-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable fz613 fz619 fzEY13696 fztow viable, with Scer\GAL4pnr-MD237 fzGD4614 Sterility Allele fertile fzEY13696 Other Phenotypes Allele cell polarity defective fz23 fzhs.sev cell polarity defective, with Scer\GAL471B fzScer\UAS.cPa fzWIFCRD.Scer\UAS cell polarity defective, with Scer\GAL4dpp.blk1 fz1-1-1.Scer\UAS.T:Hsap\MYC cell polarity defective, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa cell polarity defective (with fz19) fz20 cell polarity defective (with fz20) fz19 neuroanatomy defective | dominant fz15 planar polarity defective fz1 fz19 fz21 fz23 fz24 fz25 fz30 fzhs.P9 fzhs.P224 fzhs.PP fzhs.sev fzsev.PU fzunspecified planar polarity defective, with Scer\GAL469B fzScer\UAS.cZa planar polarity defective, with Scer\GAL471B fzScer\UAS.T:Hsap\MYC planar polarity defective, with Scer\GAL4ap-md544 fz1-1-1.Scer\UAS.T:Hsap\MYC planar polarity defective, with Scer\GAL4Bx-MS1096 fzScer\UAS.cSa planar polarity defective, with Scer\GAL4C-765 fzScer\UAS.cSa planar polarity defective, with Scer\GAL4Dll-md23 fzScer\UAS.cAa planar polarity defective, with Scer\GAL4dpp.blk1 fz1-1-1.Scer\UAS.T:Hsap\MYC fz1-1-1.ΔSWRNF.Scer\UAS.T:Hsap\MYC fzScer\UAS.cAa planar polarity defective, with Scer\GAL4dpp.PS fzScer\UAS.cAa planar polarity defective, with Scer\GAL4en-e16E fzScer\UAS.cAa fzScer\UAS.cSa planar polarity defective, with Scer\GAL4en-e16E, fz15 fzScer\UAS.cSa planar polarity defective, with Scer\GAL4en-e16E, fzScer\UAS.cSa fz15 planar polarity defective, with Scer\GAL4hh-Gal4 fzScer\UAS.cSa planar polarity defective, with Scer\GAL4hh-Gal4, fz21 fzScer\UAS.cSa planar polarity defective, with Scer\GAL4hh-Gal4, fzScer\UAS.cSa fz21 planar polarity defective, with Scer\GAL4hs.2sev fz1-1-1.Scer\UAS.T:Hsap\MYC fzScer\UAS.cAa fzScer\UAS.cZa fzScer\UAS.N planar polarity defective, with Scer\GAL4hs.2sev, fzarm.T:Avic\GFP-EGFP fzScer\UAS.cAa planar polarity defective, with Scer\GAL4hs.2sev, fzScer\UAS.cAa fzarm.T:Avic\GFP-EGFP planar polarity defective, with Scer\GAL4pnr-MD237 fzGD4614 planar polarity defective, with Scer\GAL4salm-459.2 fzScer\UAS.T:Avic\GFP-EGFP planar polarity defective, with Scer\GAL4sev.PM181 fzAA.Scer\UAS fzEE.Scer\UAS fzScer\UAS.cAa planar polarity defective, with Scer\GAL4αTub84B.PL fzScer\UAS.cSa planar polarity defective (with Df(3L)fz-D21) fz30 planar polarity defective (with fz15) fz25 fz37 planar polarity defective (with fz19) fz20 fz21 planar polarity defective (with fz20) fz19 planar polarity defective (with fz21) fz19 fz23 planar polarity defective (with fz23) fz21 planar polarity defective (with fz25) fz15 planar polarity defective (with fz37) fz15 planar polarity defective | cell autonomous, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa planar polarity defective | cell non-autonomous fz21 fz25 fzHell planar polarity defective | cell non-autonomous, with Scer\GAL4dpp.blk1 fz1-1-1.Scer\UAS.T:Hsap\MYC planar polarity defective | cell non-autonomous | recessive | somatic clone fz23 planar polarity defective | cell non-autonomous | somatic clone fz1 fz15 fz21 fz23 fz25 fzunspecified planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC fzScer\UAS.cSa planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC, fz15 fzScer\UAS.cSa planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC, fzScer\UAS.cSa fz15 planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PP fzScer\UAS.cSa planar polarity defective | dominant | heat sensitive fzI.hs planar polarity defective | heat sensitive fzhs.PP fzI.hs planar polarity defective | recessive fz21 planar polarity defective | recessive | somatic clone fz15 fz37 planar polarity defective | somatic clone fz15 fz21 fz23 fz25 fzhs.sev planar polarity defective | somatic clone, with Scer\GAL4Act5C.PI fzP278L.Scer\UAS.T:Avic\GFP-EGFP fzΔIntra.Scer\UAS.T:Avic\GFP-EGFP planar polarity defective | somatic clone, with Scer\GAL4Ubx.PdC fzScer\UAS.cSa planar polarity defective | somatic clone, with Scer\GAL4Ubx.PdC, fz15 fzScer\UAS.cSa planar polarity defective | somatic clone, with Scer\GAL4Ubx.PdC, fzScer\UAS.cSa fz15 planar polarity defective | somatic clone (with fz19) fz20 planar polarity defective | somatic clone (with fz20) fz19 visible fz1 fz3 fz14 fz17 fz18 fz19 fz21 fz22 fz23 fz24 fz26 fz28 fz29 fz30 fz31 fz32 fz33 fz34 fz35 fz36 fz37 fztow visible, with Scer\GAL469B fzScer\UAS.N visible, with Scer\GAL4C-765 fzScer\UAS.cSa visible, with Scer\GAL4Dll-md23 fzScer\UAS.cAa visible, with Scer\GAL4dpp.blk1 fzScer\UAS.cAa visible, with Scer\GAL4en-e16E fzScer\UAS.cAa visible, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa visible (with fz13) fz30 visible (with fz19) fz30 visible (with fz23) fz30 visible (with fz24) fz30 visible (with fz25) fz30 visible (with fz30) fz13 fz19 fz23 fz24 fz25 fzCK fzCL fzED fzGL31 fzHE11 fzJB fzJW fzKW fzMG fzMP fzRN fzSN fzSY fzTT visible (with fzCK) fz30 visible (with fzCL) fz30 visible (with fzED) fz30 visible (with fzGL31) fz30 visible (with fzHE11) fz30 visible (with fzJB) fz30 visible (with fzJW) fz30 visible (with fzKW) fz30 visible (with fzMG) fz30 visible (with fzMP) fz30 visible (with fzRN) fz30 visible (with fzSN) fz30 visible (with fzSY) fz30 visible (with fzTT) fz30 visible | cold sensitive fzHD21 visible | cold sensitive (with fz30) fzHD21 visible | cold sensitive (with fzHD21) fz30 visible | heat sensitive fzhs.PP fzI.hs visible | recessive fz21 fz24 visible | somatic clone fz21 wild-type fzAct5C.T:Avic\GFP-EGFP fzarm.T:Avic\GFP-EGFP fzI.hs wild-type, with Scer\GAL4Dll-md23 fz1-1-1.Scer\UAS.T:Hsap\MYC Phenotype manifest in Allele axon & dorsal cluster neuron fz15 border follicle cell, with Scer\GAL4slbo.2.6 fzScer\UAS.cAa fzdsRNA.Scer\UAS border follicle cell (with fz15) fz23 border follicle cell (with fz23) fz15 border follicle cell | cell non-autonomous | somatic clone fz15 border follicle cell | somatic clone fz15 bract fz1 denticle belt, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 fzScer\UAS.cAa denticle belt, with Scer\GAL4ptc-559.1 fzScer\UAS.cZa denticle row 1, with Scer\GAL4en-e16E fzScer\UAS.cZa dorsal triple row, with Scer\GAL469B fzScer\UAS.N dorsal wing blade (with fz21) fz23 dorsal wing blade (with fz23) fz21 dorsal wing blade | somatic clone (with fz15) fz23 dorsal wing blade | somatic clone (with fz23) fz15 embryonic/first instar larval cuticle, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 fzScer\UAS.cAa embryonic/larval dorsal trunk (with fz21) fz30 embryonic/larval dorsal trunk (with fz30) fz21 embryonic epidermis fzhs.sev embryonic neuroblast fz23 fz30 external sensory organ precursor cell I fz25 external sensory organ precursor cell I (with fz30) fz37 external sensory organ precursor cell I (with fz37) fz30 external sensory organ precursor cell I & centrosome (with fz30) fz37 external sensory organ precursor cell I & centrosome (with fz37) fz30 external sensory organ precursor cell I & spindle (with fz30) fz37 external sensory organ precursor cell I & spindle (with fz37) fz30 eye fz1 eye, with Scer\GAL4hs.2sev fz1-1-1.Scer\UAS.T:Hsap\MYC fzScer\UAS.N fzScer\UAS.cAa fzScer\UAS.cZa eye (with fz15) fz30 eye (with fz21) fz23 eye (with fz23) fz21 eye (with fz30) fz15 eye | heat sensitive fzI.hs eye photoreceptor cell fz37 eye photoreceptor cell | somatic clone fz25 eye photoreceptor cell | somatic clone (with fz19) fz20 eye photoreceptor cell | somatic clone (with fz20) fz19 joint fz1 joint | ectopic fzunspecified lens (with fz15) fz30 lens (with fz30) fz15 lymph gland derived hemocyte | third instar larval stage, with Scer\GAL4dome-PG14 fzScer\UAS.N macrochaeta fzBG01720 macrochaeta & adult abdomen | somatic clone | cell non-autonomous fz1 macrochaeta & adult thorax fz14 fz17 fz18 fz19 fz21 fz22 fz23 fz24 fz26 fz28 fz29 fz3 fz30 fz31 fz32 fz33 fz34 fz35 fz36 macrochaeta & eye fz37 macrochaeta | ectopic, with Scer\GAL4ap-md52 fzScer\UAS.cAa macrochaeta | heat sensitive fzI.hs medial triple row, with Scer\GAL469B fzScer\UAS.N mesothoracic tergum, with Scer\GAL4ap-md544 fz1-1-1.Scer\UAS.T:Hsap\MYC mesothoracic tergum & sensory mother cell & spindle (with fz30) fz37 mesothoracic tergum & sensory mother cell & spindle (with fz37) fz30 microchaeta, with Scer\GAL4ap-md52 fzScer\UAS.cAa microchaeta & adult abdomen | somatic clone | cell non-autonomous fz1 microchaeta & adult thorax | somatic clone | cell non-autonomous fz1 ommatidium fz1 fz15 fz37 fzhs.sev fzsev.PU ommatidium, with Scer\GAL4hs.2sev fzScer\UAS.N fzScer\UAS.cAa fzScer\UAS.cZa ommatidium, with Scer\GAL4hs.2sev, fzarm.T:Avic\GFP-EGFP fzScer\UAS.cAa ommatidium, with Scer\GAL4hs.2sev, fzScer\UAS.cAa fzarm.T:Avic\GFP-EGFP ommatidium, with Scer\GAL4sev.PM181 fzScer\UAS.cAa fzAA.Scer\UAS fzEE.Scer\UAS ommatidium, with Scer\GAL4unspecified fzScer\UAS.cSa ommatidium (with fz15) fz30 fz37 ommatidium (with fz19) fz20 fz21 ommatidium (with fz20) fz19 ommatidium (with fz21) fz19 ommatidium (with fz30) fz15 ommatidium (with fz37) fz15 ommatidium | somatic clone fz15 fz25 fz37 fzhs.sev ommatidium | somatic clone (with fz19) fz20 ommatidium | somatic clone (with fz20) fz19 photoreceptor cell R3 | ectopic fzhs.sev photoreceptor cell R3 | ectopic, with Scer\GAL4sev.PM181 fzScer\UAS.cAa fzAA.Scer\UAS photoreceptor cell R3 | supernumerary, with Scer\GAL4hs.2sev fzScer\UAS.cAa photoreceptor cell R4 fzhs.sev photoreceptor cell R4, with Scer\GAL4hs.2sev fzScer\UAS.cAa photoreceptor cell R4, with Scer\GAL4sev.PM181 fzScer\UAS.cAa fzAA.Scer\UAS photoreceptor cell R4 | somatic clone fzhs.sev polar follicle cell, with Scer\GAL4slbo.2.6 fzdsRNA.Scer\UAS polar follicle cell | somatic clone fz15 presumptive embryonic salivary gland fz1 presumptive embryonic salivary gland, with Scer\GAL4fkh.PZ fzScer\UAS.N RP2 motor neuron fz1 fz23 fz30 sensory mother cell fz25 sensory mother cell & spindle, with Scer\GAL4ap-md52 fzScer\UAS.cAa socket | supernumerary (with fz30) fz37 socket | supernumerary (with fz37) fz30 spindle fz25 spindle & external sensory organ precursor cell I (with fz30) fz37 spindle & external sensory organ precursor cell I (with fz37) fz30 tarsal segment fz1 tarsal segment 1 & joint fzunspecified tarsal segment 2 fzunspecified tarsal segment 3 fzunspecified tarsal segment 4 fzunspecified thorax fztow trichogen cell | supernumerary fz30 fz37 trichome & abdominal tergite fzunspecified trichome & adult abdomen, with Scer\GAL4hh-Gal4 fzScer\UAS.cSa trichome & adult abdomen | somatic clone fz15 trichome & adult abdomen | somatic clone | cell non-autonomous fz15 trichome & pleural membrane fzunspecified trichome & pleural membrane, with Scer\GAL4en-e16E fzScer\UAS.cSa trichome & pleural membrane, with Scer\GAL4en-e16E, fz15 fzScer\UAS.cSa trichome & pleural membrane, with Scer\GAL4en-e16E, fzScer\UAS.cSa fz15 trichome & pleural membrane, with Scer\GAL4hh-Gal4 fzScer\UAS.cSa trichome & pleural membrane, with Scer\GAL4hh-Gal4, fz21 fzScer\UAS.cSa trichome & pleural membrane, with Scer\GAL4hh-Gal4, fzScer\UAS.cSa fz21 trichome & pleural membrane, with Scer\GAL4αTub84B.PL fzScer\UAS.cSa trichome & pleural membrane | somatic clone fz15 trichome & pleural membrane | somatic clone, with Scer\GAL4Ubx.PdC fzScer\UAS.cSa trichome & pleural membrane | somatic clone, with Scer\GAL4Ubx.PdC, fz15 fzScer\UAS.cSa trichome & pleural membrane | somatic clone, with Scer\GAL4Ubx.PdC, fzScer\UAS.cSa fz15 trichome & pleural membrane | somatic clone | cell non-autonomous fz15 trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4Ubx.PdC fzScer\UAS.cSa trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4Ubx.PdC, fz15 fzScer\UAS.cSa trichome & pleural membrane | somatic clone | cell non-autonomous, with Scer\GAL4Ubx.PdC, fzScer\UAS.cSa fz15 ventral triple row, with Scer\GAL469B fzScer\UAS.N wing fz122 fz13 fz15 fz16 fz19 fz20 fz21 fz23 fz24 fz30 fzC19 fzEAB2a fzGL31 fzHB41 fzHC52 fzHD21 fzHE11 fzhs.PP fztow wing, with Scer\GAL469B fzScer\UAS.N fzScer\UAS.cZa wing, with Scer\GAL471B fzScer\UAS.T:Hsap\MYC wing, with Scer\GAL4ap-md544 fz1-1-1.Scer\UAS.T:Hsap\MYC wing (with Df(3L)fz-D21) fz30 wing & macrochaeta fz1 wing & microchaeta fz25 fz30 wing & microchaeta, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa wing & microchaeta | distal fzI.hs wing & microchaeta | distal, with Scer\GAL4Dll-md23 fzScer\UAS.cAa wing | anterior/posterior compartment boundary, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa wing | anterior compartment, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa wing | cell non-autonomous | somatic clone fz21 fz23 fz25 fzHell wing | cold sensitive fzHD21 wing | heat sensitive fzI.hs wing | somatic clone fzunspecified wing cell | P-stage fz21 wing cell | P-stage | cell non-autonomous | somatic clone fz23 wing cell | P-stage | somatic clone fz23 wing disc fz1 wing hair fz1 fz14 fz17 fz18 fz19 fz21 fz22 fz23 fz24 fz25 fz26 fz28 fz29 fz3 fz30 fz31 fz32 fz33 fz34 fz35 fz36 fzI.hs fzhs.PP fzunspecified wing hair, with Scer\GAL469B fzScer\UAS.cZa wing hair, with Scer\GAL4Bx-MS1096 fzScer\UAS.cSa wing hair, with Scer\GAL4C-765 fzScer\UAS.cSa wing hair, with Scer\GAL4Dll-md23 fzScer\UAS.cAa wing hair, with Scer\GAL4dpp.blk1 fz1-1-1.ΔSWRNF.Scer\UAS.T:Hsap\MYC fz1-1-1.Scer\UAS.T:Hsap\MYC fzScer\UAS.cAa wing hair, with Scer\GAL4dpp.PS fzScer\UAS.cAa wing hair, with Scer\GAL4en-e16E fzScer\UAS.cAa wing hair, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa wing hair, with Scer\GAL4salm-459.2 fzScer\UAS.T:Avic\GFP-EGFP wing hair (with fz15) fz25 wing hair (with fz21) fz23 wing hair (with fz23) fz21 wing hair (with fz25) fz15 wing hair & 1st posterior cell, with Scer\GAL4ptc-559.1 fzScer\UAS.cAa wing hair | cell non-autonomous, with Scer\GAL4dpp.blk1 fz1-1-1.Scer\UAS.T:Hsap\MYC wing hair | cell non-autonomous | somatic clone fz21 fz23 fz25 fzunspecified wing hair | cold sensitive fzHD21 wing hair | heat sensitive fzI.hs fzhs.PP wing hair | P-stage, with Scer\GAL4dpp.blk1 fzScer\UAS.cAa wing hair | somatic clone fz21 fz23 fz25 fzunspecified wing hair | somatic clone, with Scer\GAL4Act5C.PI fzΔIntra.Scer\UAS.T:Avic\GFP-EGFP fzP278L.Scer\UAS.T:Avic\GFP-EGFP wing hair | supernumerary fzunspecified wing hair | supernumerary, with Scer\GAL4Bx-MS1096 fzScer\UAS.cSa wing hair | supernumerary, with Scer\GAL4salm-459.2 fzScer\UAS.T:Avic\GFP-EGFP wing hair | supernumerary (with fz13) fz30 wing hair | supernumerary (with fz19) fz30 wing hair | supernumerary (with fz23) fz30 wing hair | supernumerary (with fz24) fz30 wing hair | supernumerary (with fz25) fz30 wing hair | supernumerary (with fz30) fz13 fz19 fz23 fz24 fz25 fzCK fzCL fzED fzGL31 fzHE11 fzJB fzJW fzKW fzMG fzMP fzRN fzSN fzSY fzTT wing hair | supernumerary (with fzCK) fz30 wing hair | supernumerary (with fzCL) fz30 wing hair | supernumerary (with fzED) fz30 wing hair | supernumerary (with fzGL31) fz30 wing hair | supernumerary (with fzHE11) fz30 wing hair | supernumerary (with fzJB) fz30 wing hair | supernumerary (with fzJW) fz30 wing hair | supernumerary (with fzKW) fz30 wing hair | supernumerary (with fzMG) fz30 wing hair | supernumerary (with fzMP) fz30 wing hair | supernumerary (with fzRN) fz30 wing hair | supernumerary (with fzSN) fz30 wing hair | supernumerary (with fzSY) fz30 wing hair | supernumerary (with fzTT) fz30 wing hair | supernumerary | cold sensitive (with fz30) fzHD21 wing hair | supernumerary | cold sensitive (with fzHD21) fz30 wing hair | supernumerary | heat sensitive fzI.hs wing margin, with Scer\GAL4C-765 fzScer\UAS.cSa wing margin, with Scer\GAL4en-e16E fz1-1-1.Scer\UAS.T:Hsap\MYC wing margin bristle fzunspecified wing margin bristle, with Scer\GAL469B fzScer\UAS.cZa wing margin bristle, with Scer\GAL4en-e16E fz1-1-1.Scer\UAS.T:Hsap\MYC wing margin bristle | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PP fzScer\UAS.cSa wing margin bristle | ectopic, with Scer\GAL471B fzWIFCRD.Scer\UAS wing margin bristle | somatic clone fzGL31
Classical Alleles ( 98 )
For All Classical Alleles Show
Allele of fz Class Mutagen Stocks Known lesion fz1 hypomorphic allele - genetic evidence spontaneous 5 -- fz21 ethyl methanesulfonate 1 Yes fzBG00824 P-element activity 1 -- fzc03480 piggyBac transposase 1 -- fzc05547 piggyBac transposase 1 -- fzd01490 P-element activity 1 -- fze00573 piggyBac transposase 1 -- fze01331 piggyBac transposase 1 -- fze01695 piggyBac transposase 1 -- fze01735 piggyBac transposase 1 -- fze03401 piggyBac transposase 1 -- fzEY03114 P-element activity 1 -- fzEY13696 P-element activity 1 -- fzf00972 piggyBac transposase 1 -- fzf06745 piggyBac transposase 1 -- fzf06941 piggyBac transposase 1 -- fzf07870 piggyBac transposase 1 -- fzMB07478 1 -- fzMI01820 1 -- fzMI04227 1 -- fzMI06816 1 -- fzNP5457 1 -- fzNP5624 1 -- fzNP5629 1 -- fzNP7514 1 -- fz15 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 Yes fz30 amorphic allele - genetic evidence gamma ray 0 -- fz37 amorphic allele - genetic evidence PM hybrid dysgenesis 0 Yes fz3 amorphic allele - genetic evidence gamma ray X ray 0 Yes fzGE2b amorphic allele - genetic evidence gamma ray 0 Yes fzGN6a amorphic allele - genetic evidence gamma ray 0 Yes fz10 ethyl methanesulfonate 0 -- fz11 ethyl methanesulfonate 0 -- fz122 ethyl methanesulfonate 0 -- fz12 ethyl methanesulfonate 0 -- fz13 neomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes fz14 ethyl methanesulfonate 0 -- fz16 ethyl methanesulfonate 0 Yes fz17 ethyl methanesulfonate 0 -- fz18 ethyl methanesulfonate 0 -- fz19 ethyl methanesulfonate 0 Yes fz20 ethyl methanesulfonate 0 Yes fz22 ethyl methanesulfonate 0 -- fz23 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes fz24 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes fz25 ethyl methanesulfonate 0 Yes fz26 gamma ray 0 Yes fz28 gamma ray 0 Yes fz29 gamma ray 0 -- fz2 spontaneous 0 -- fz31 PM hybrid dysgenesis 0 -- fz32 PM hybrid dysgenesis 0 -- fz33 PM hybrid dysgenesis 0 -- fz34 PM hybrid dysgenesis 0 Yes fz35 PM hybrid dysgenesis 0 -- fz36 PM hybrid dysgenesis 0 -- fz38 PM hybrid dysgenesis 0 Yes fz4 gamma ray 0 -- fz50b spontaneous 0 -- fz50c spontaneous 0 -- fz5 X ray 0 -- fz613 X ray 0 -- fz619 X ray 0 -- fz6 X ray 0 -- fz7 X ray 0 -- fz8 X ray 0 -- fz9131 0 -- fz9 ethyl methanesulfonate 0 -- fzBG01720 P-element activity 0 Yes fzBrd3 0 -- fzC19 ethyl methanesulfonate 0 -- fzCK ethyl nitrosourea 0 Yes fzCL ethyl nitrosourea 0 Yes fzCT8D 0 Yes fzEAB2a ethyl methanesulfonate 0 -- fzED ethyl nitrosourea 0 Yes fzGD4b gamma ray 0 Yes fzGl1a hypomorphic allele - genetic evidence 0 -- fzGL31 ethyl methanesulfonate 0 Yes fzGL3a gamma ray 0 Yes fzH5 0 -- fzHB41 ethyl methanesulfonate 0 Yes fzHC52 ethyl methanesulfonate 0 Yes fzHD21 ethyl methanesulfonate 0 Yes fzHE11 ethyl methanesulfonate 0 Yes fzHell 0 -- fzJB ethyl nitrosourea 0 Yes fzJW ethyl nitrosourea 0 Yes fzKB4b PM hybrid dysgenesis 0 Yes fzKW ethyl nitrosourea 0 Yes fzMG ethyl nitrosourea 0 Yes fzMP ethyl nitrosourea 0 Yes fzRN ethyl nitrosourea 0 Yes fzSN ethyl nitrosourea 0 Yes fzSY ethyl nitrosourea 0 Yes fztow 0 Yes fzTT ethyl nitrosourea 0 Yes fzunspecified 0 --
Alleles Carried on Transgenic Constructs ( 97 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fz Class Mutagen Stocks Known lesion fz1-1-1.Scer\UAS.T:Hsap\MYC gain of function allele in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes fzGD4614 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes fzHMS01308 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzJF01258 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzJF01481 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzKK108004 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fz1-1-1.565Stop.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes fz1-1-1.hs.2sev FLPase 0 Yes fz1-1-1.KEP-APD.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.KEP-APD.tub.W in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.M469R.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes fz1-1-1.RT-AA.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.RT-AA.tub.W in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.Scer\FRT.hs.2sev in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fz1-1-1.Scer\FRT.αTub84B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fz1-1-1.tub.W in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fz1-1-1.V559E.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.V559E.tub.W in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.VE-WR.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.VE-WR.tub.W in vitro construct - site directed mutagenesis 0 Yes fz1-1-1.αTub84B FLPase 0 Yes fz1-1-1.ΔCRD.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes fz1-1-1.ΔLQG.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes fz1-1-1.ΔLQG.tub.W in vitro construct - deletion 0 Yes fz1-1-1.ΔSKT.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes fz1-1-1.ΔSKT.tub.W in vitro construct - deletion 0 Yes fz1-1-1.ΔSWRNF.Scer\UAS.T:Hsap\MYC in vitro construct - deletion 0 Yes fz1-1-1.ΔSWRNF.tub.W in vitro construct - deletion 0 Yes fz374-2360 in vitro construct - RNAi 0 Yes fz565Stop.tub.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes fz57.αTub84B in vitro construct - regulatory fusion in vitro construct 0 Yes fz81.αTub84B in vitro construct - regulatory fusion in vitro construct 0 Yes fza.374-2360 in vitro construct - RNAi in vitro construct 0 Yes fzAA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes fzAct5C.PK in vitro construct - regulatory fusion 0 Yes fzAct5C.Scer\FRT.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes fzAct5C.Scer\FRT.T:Avic\GFP-EYFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes fzAct5C.T:Avic\GFP-EGFP FLPase 0 Yes fzAct5C.T:Avic\GFP-EYFP FLPase 0 Yes fzarm.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes fzcPa in vitro construct 0 Yes fzCRD.GPI.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fzCterm.Act5C.T:Avic\GFP in vitro construct - coding region fusion 0 Yes fzdsRNA.A in vitro construct - RNAi 0 Yes fzdsRNA.cLa in vitro construct - RNAi 0 Yes fzdsRNA.cMa in vitro construct - RNAi 0 -- fzdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes fzEE.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes fzGMR.PA in vitro construct - regulatory fusion 0 Yes fzGMR.PZ in vitro construct - regulatory fusion 0 Yes fzGSG15.αTub84B in vitro construct 0 Yes fzGSG18.αTub84B in vitro construct 0 Yes fzhs.P224 in vitro construct - regulatory fusion 0 Yes fzhs.P9 in vitro construct - regulatory fusion 0 Yes fzhs.PP in vitro construct - regulatory fusion 0 Yes fzhs.sev in vitro construct - regulatory fusion 0 Yes fzI.hs in vitro construct - regulatory fusion 0 Yes fzII.hs in vitro construct - regulatory fusion 0 Yes fzM469R.tub.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes fzMtnA.PT in vitro construct - regulatory fusion 0 Yes fzMtnA.PY in vitro construct - regulatory fusion 0 -- fzNIG.17697R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes fzP278L.Act5C.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes fzP278L.Act5C.T:Avic\GFP-EYFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fzP278L.arm.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes fzP278L.Scer\FRT.Act5C.T:Avic\GFP-EYFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 -- fzP278L.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes fzP278L.Scer\UAS in vitro construct - regulatory fusion 0 -- fzScer\UAS.cAa in vitro construct - regulatory fusion 0 -- fzScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes fzScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes fzScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes fzScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes fzScer\UAS.N in vitro construct - regulatory fusion 0 Yes fzScer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes fzScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fzScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fzsev.PT in vitro construct - regulatory fusion 0 Yes fzsev.PU in vitro construct - regulatory fusion 0 Yes fzsevE.SevP.PS in vitro construct - regulatory fusion 0 Yes fzsevE3.SevP.PS in vitro construct - regulatory fusion 0 Yes fzsmoCRD.αTub84B in vitro construct - regulatory fusion in vitro construct 0 Yes fztub.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fzUbi.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes fzWIFCRD.Scer\UAS in vitro construct - regulatory fusion 0 Yes fzWIFCRD.αTub84B in vitro construct - regulatory fusion in vitro construct 0 Yes fzαTub84B.PP in vitro construct - regulatory fusion 0 -- fzΔCRD.tub.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes fzΔCRD.αTub84B.T:SS-wg,T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes fzΔCRD1.αTub84B in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes fzΔCRD3.αTub84B.T:SS-wg,T:Ivir\HA1 in vitro construct - deletion 0 Yes fzΔIntra.Act5C.T:Avic\GFP-EYFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes fzΔIntra.arm.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes fzΔIntra.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes fzΔIntra.Scer\UAS.T:Avic\GFP-EYFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 -- fzΔSKT.tub.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes fzΔSWRNF.tub.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)D-4rv34 (Carpenter, 1994) Df(3L)D4rv42 (Carpenter, 1994) Df(3L)D5 (Carpenter, 1994) Df(3L)Exel6122 (Ryder, 2004.4.26) Df(3L)fz-D21 (Freeman et al., 1986, Adler et al., 1994, Park et al., 1994) Df(3L)fz-GF3b (Carpenter, 1994) In(3L)Brd3 (Leviten and Posakony, 1996) In(3L)fzK21 (Park et al., 1994)
Not disrupted in	Df(3L)DTS5-3 (Velissariou and Ashburner, 1981) Df(3L)DTS5-4 (Velissariou and Ashburner, 1981) Df(3L)st2 (Velissariou and Ashburner, 1981) Df(3L)st3 (Velissariou and Ashburner, 1981) Df(3L)st4 (Velissariou and Ashburner, 1981) Df(3L)st6 (Velissariou and Ashburner, 1981) Df(3L)st7 (Velissariou and Ashburner, 1981) Df(3L)st103 (Velissariou and Ashburner, 1981) Df(3L)st106 (Velissariou and Ashburner, 1981) Df(3L)th1 (Velissariou and Ashburner, 1981) Df(3L)th2 (Velissariou and Ashburner, 1981) Df(3L)th45 (Velissariou and Ashburner, 1981) Df(3L)th102 (Velissariou and Ashburner, 1981) Df(3L)th112 (Velissariou and Ashburner, 1981) Df(3L)th113 (Velissariou and Ashburner, 1981) Df(3L)th117 (Velissariou and Ashburner, 1981) In(3L)st5 (Velissariou and Ashburner, 1981)
Duplicated in	Dp(3;4)D4rv42 (Carpenter, 1994)
Partially disrupted in	In(3L)towfz (Chung et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
UAS construct	Name Expression Data P{GD4614} NA P{KK108004} NA P{NIG.17697R} NA P{TRiP.HMS01308} NA P{TRiP.JF01258} NA P{TRiP.JF01481} NA P{UAS-fz1-1-1.565Stop.MYC} NA P{UAS-fz1-1-1.KEP-APD} NA P{UAS-fz1-1-1.M469R.MYC} NA P{UAS-fz1-1-1.RT-AA} NA P{UAS-fz1-1-1.V559E} NA P{UAS-fz1-1-1.VE-WR} NA P{UAS-fz1-1-1.ΔLQG} NA P{UAS-fz1-1-1.ΔSKT} NA P{UAS-fz1-1-1.ΔSWRNF} NA P{UAS-fz1-1} NA P{UAS-fz.A} NA P{UAS-fz.AA} NA P{UAS-fz.CRD-GPI} NA P{UAS-fz.EE} NA P{UAS-fz.GFP} NA P{UAS-fz.HA} NA P{UAS-fz.myc} NA P{UAS-fz.N} NA P{UAS-fz.P278L.GFP} NA P{UAS-fz.P278L} NA P{UAS-fz.RNAi} NA P{UAS-fz.S} NA P{UAS-fz.U} NA P{UAS-fz.WIFCRD} NA P{UAS-fz.Z} NA P{UAS-fz.ΔCRD.MYC} NA P{UAS-fz.ΔIntra.EYFP} NA P{UAS-fz.ΔIntra.GFP} NA
heat-shock construct	Name Expression Data P{hs.2sev(FRT.wGMR)fz.1-1-1} NA P{hs.2sev(-FRT)fz.1-1-1} NA P{hs-fz.9} NA P{hs-fz.224} NA P{hs-fz} NA P{hsfzI} NA P{hsfzII} NA P{sev-fz.T} NA
characterization construct	Name Expression Data P{1Xsev-fz.T} NA P{Act5C(FRT.polyA)fz.EGFP} NA P{Act5C(FRT.polyA)fz.EYFP} NA P{Act5C(-FRT)fz.EGFP} NA P{Act5C(-FRT)fz.EYFP} NA P{Act5C-fz.P278L.EYFP} NA P{Act5C-fz.P278L.GFP} NA P{Act5C-fz.P278L.YFP} NA P{Act5C-fz.ΔIntra.EYFP} NA P{arm-fz.GFP} NA P{arm-fz.P278L.GFP} NA P{arm-fz.ΔIntra.GFP} NA P{Glfz} NA P{GMR-fz.A} NA P{hs.2sev(FRT.wGMR)fz::fz2.1-1-2} NA P{hs.2sev(FRT.wGMR)fz::fz2.1-2-1} NA P{hs.2sev(FRT.wGMR)fz::fz2.1-2-2} NA P{hs.2sev(FRT.wGMR)fz::fz2.2-1-1} NA P{hs.2sev(FRT.wGMR)fz::fz2.2-2-1} NA P{hs.2sev(-FRT)fz::fz2.1-1-2} NA P{hs.2sev(-FRT)fz::fz2.1-2-1} NA P{hs.2sev(-FRT)fz::fz2.1-2-2} NA P{hs.2sev(-FRT)fz::fz2.2-1-1} NA P{hs.2sev(-FRT)fz::fz2.2-2-1} NA P{SevE3.SevP-fz.S} NA P{SevE.SevP-fz.S} NA P{sev-fz.U} NA P{tub-fz1-1-1.C2} NA P{tub-fz1-1-1.KEP-APD} NA P{tub-fz1-1-1.RT-AA} NA P{tub-fz1-1-1.V559E} NA P{tub-fz1-1-1.VE-WR} NA P{tub-fz1-1-1.ΔLQG} NA P{tub-fz1-1-1.ΔSKT} NA P{tub-fz1-1-1.ΔSWRNF} NA P{tub-fz1-1-1} NA P{tub-fz1-1-2} NA P{tub-fz1-1-2S} NA P{tub-fz1-2-1} NA P{tub-fz1-2-2S} NA P{tub-fz1-2} NA P{tub-fz2-1} NA P{tub-fz2-2-1} NA P{tub-fz::fz2.2-1-1.MYC} NA P{tub-fz.565Stop.MYC} NA P{tub-fz.M469R.MYC} NA P{tub-fz.MYC} NA P{tub-fz.ΔCRD.MYC} NA P{tub-fz.ΔSKT.MYC} NA P{tub-fz.ΔSWRNF.MYC} NA P{Tubα1-fzΔCRD3.HA} NA P{Tubα1-fzΔCRD.HA} NA P{UAS-fz1-1-1.C2} NA P{UAS-fz1-1-2} NA P{UAS-fz1-1-2S} NA P{UAS-fz1-2-1} NA P{UAS-fz1-2-2S} NA P{UAS-fz1-2} NA P{UAS-fz2-1-2} NA P{UAS-fz2-1} NA P{UAS-fz2-2-1} NA P{UAS-fz2CRD.fz} NA P{UAS-fz::fz2.1-1-2} NA P{UAS-fz::fz2.1-2-2} NA P{UAS-fz::fz2.2-1-1} NA P{UAS-fz::smo.FFS} NA P{UAS-fz::smo.FSF} NA P{UAS-fz::smo.FSS} NA P{UAS-fz::smo.SFF} NA P{UAS-fz::smo.SFS} NA P{UAS-fz::smo.SSF} NA P{UAS-fz::wntD.ΔCRD} NA P{UAS-fzCRD.fz2} NA P{Ubi-fz.3xEGFP} NA P{αTub84B(FRT.wGMR)fz::fz2.1-1-2} NA P{αTub84B(FRT.wGMR)fz::fz2.1-2-1} NA P{αTub84B(FRT.wGMR)fz::fz2.1-2-2} NA P{αTub84B(FRT.wGMR)fz::fz2.2-1-1} NA P{αTub84B(FRT.wGMR)fz::fz2.2-2-1} NA P{αTub84B(FRT.wGMR)fz.1-1-1} NA P{αTub84B(-FRT)fz::fz2.1-1-2} NA P{αTub84B(-FRT)fz::fz2.1-2-1} NA P{αTub84B(-FRT)fz::fz2.1-2-2} NA P{αTub84B(-FRT)fz::fz2.2-1-1} NA P{αTub84B(-FRT)fz::fz2.2-2-1} NA P{αTub84B(-FRT)fz.1-1-1} NA P{αTub84B-fz::wg.δCRD} NA P{αTub84B-fz::wntD.ΔCRD} NA P{αTub84B-fz.57} NA P{αTub84B-fz.81} NA P{αTub84B-fz.CRD1} NA P{αTub84B-fz.GSG15} NA P{αTub84B-fz.GSG18} NA P{αTub84B-fz.P} NA P{αTub84B-fz.smoCRD} NA P{αTub84B-fz.WIFCRD} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}fz21 NA ?{}fz28 NA ?{}fzGD4b NA ?{}fzGL3a NA Mi{MIC}fzMI01820 NA Mi{MIC}fzMI04227 NA Mi{MIC}fzMI06816 NA P{}fz34 NA P{GT1}BG01047BG01047 NA P{GT1}fzBG00824 NA P{GT1}fzBG01720 NA PBac{PB}fzc03480 NA PBac{PB}fzc05547 NA PBac{RB}fze00573 NA PBac{RB}fze01331 NA PBac{RB}fze01695 NA PBac{RB}fze01735 NA PBac{RB}fze03401 NA PBac{WH}fzf00972 NA PBac{WH}fzf06745 NA PBac{WH}fzf06941 NA PBac{WH}fzf07870 NA insertion of mobile activating element P{EPgy2}fzEY03114 NA P{EPgy2}fzEY13696 NA P{XP}fzd01490 NA insertion of enhancer trap binary system Mi{ET1}fzMB07478 No P{GawB}fzNP5457 No P{GawB}fzNP5624 No P{GawB}fzNP5629 No P{GawB}fzNP7514 No
Gene Ontology: Function, Process & Cellular Component ( 44 unique terms )
Terms Based on Experimental Evidence ( 27 terms )
Molecular Function
CV term Evidence References
Wnt-activated receptor activity inferred from direct assay (Povelones and Nusse, 2005) Wnt-protein binding inferred from physical interaction with wg, Wnt2, Wnt4 (Wu and Nusse, 2002)
Biological Process
CV term Evidence References
asymmetric cell division inferred from mutant phenotype (Katanaev and Tomlinson, 2006) axon extension inferred from mutant phenotype (Srahna et al., 2006) border follicle cell migration inferred from mutant phenotype (Bastock and Strutt, 2007) canonical Wnt receptor signaling pathway inferred from genetic interaction with wg (Povelones and Nusse, 2005) compound eye morphogenesis inferred from mutant phenotype (Kryuchkov et al., 2011) establishment of cell polarity inferred from mutant phenotype (Strutt, 2001) establishment of epithelial cell apical/basal polarity inferred from mutant phenotype (Ma et al., 2003) establishment of imaginal disc-derived wing hair orientation inferred from expression pattern AND inferred from mutant phenotype (Strutt, 2001) inferred from mutant phenotype (Usui et al., 1999, Klein et al., 2006) establishment of ommatidial planar polarity inferred from mutant phenotype (Zheng et al., 1995, Yang et al., 2002, Strutt et al., 2006, Klein et al., 2006) establishment of planar polarity inferred from mutant phenotype (Usui et al., 1999) establishment or maintenance of cell polarity inferred from mutant phenotype (Povelones and Nusse, 2005) inferred from mutant phenotype (assigned by UniProtKB) (Vinson et al., 1989) homophilic cell adhesion inferred from mutant phenotype (Usui et al., 1999) imaginal disc-derived wing hair organization inferred from genetic interaction with ck (Winter et al., 2001) inferred from genetic interaction with Rho1 (Winter et al., 2001) inferred from genetic interaction with rok (Winter et al., 2001) inferred from genetic interaction with sqh (Winter et al., 2001) inferred from genetic interaction with zip (Winter et al., 2001) imaginal disc-derived wing hair site selection inferred from mutant phenotype (Adler et al., 1994) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) morphogenesis of a polarized epithelium inferred from mutant phenotype (Classen et al., 2005) ommatidial rotation inferred from mutant phenotype (Zheng et al., 1995) regulation of actin filament bundle assembly inferred from genetic interaction with rok (Winter et al., 2001) regulation of hemocyte proliferation inferred from mutant phenotype (Sinenko et al., 2010) regulation of tube length, open tracheal system inferred from mutant phenotype (Chung et al., 2009) salivary gland morphogenesis inferred from mutant phenotype (Harris and Beckendorf, 2007) sensory organ precursor cell fate determination inferred from mutant phenotype (Bellaiche et al., 2001)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Strutt, 2001) colocalizes_with endosome inferred from direct assay (Shimada et al., 2006) plasma membrane inferred from direct assay (Park et al., 1994, Povelones and Nusse, 2005)
Terms Based on Predictions or Assertions ( 24 terms )
Molecular Function
CV term Evidence References
PDZ domain binding inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) transmembrane signaling receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) Wnt-activated receptor activity traceable author statement (Zhang and Carthew, 1998) Wnt-protein binding inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity (assigned by UniProtKB) (Swiss-Prot Project Members, 1990.11.1)
Biological Process
CV term Evidence References
asymmetric protein localization traceable author statement (Wedlich, 2002) brain development inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) embryo development inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) establishment of imaginal disc-derived wing hair orientation traceable author statement (Strutt and Strutt, 2002) establishment of ommatidial planar polarity traceable author statement (Strutt and Strutt, 2002, McNeill, 2002, Wedlich, 2002, Tree et al., 2002) establishment of planar polarity traceable author statement (Torban et al., 2004, Mlodzik, 2002) establishment of tissue polarity non-traceable author statement (Van Aelst and Symons, 2002, Wedlich, 2002) gonad development inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) heart development non-traceable author statement (Cripps and Olson, 2002) ommatidial rotation traceable author statement (Van Aelst and Symons, 2002) protein localization traceable author statement (Van Aelst and Symons, 2002, Cadigan, 2002) R3/R4 cell fate commitment non-traceable author statement (Mlodzik, 2002) traceable author statement (Wedlich, 2002) regulation of transcription from RNA polymerase II promoter inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) signal transduction inferred from sequence or structural similarity (Brody and Cravchik, 2000) vasculature development inferred from biological aspect of ancestor with PANTHER:PTN000139394 (assigned by RefGenome) (Gaudet et al., 2010) Wnt receptor signaling pathway inferred from sequence or structural similarity (assigned by UniProtKB) (Swiss-Prot Project Members, 1990.11.1) non-traceable author statement (Van Aelst and Symons, 2002) traceable author statement (Zhang and Carthew, 1998)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Brody and Cravchik, 2000) non-traceable author statement (assigned by UniProtKB) (Adler et al., 1990, Swiss-Prot Project Members, 1990.11.1) integral to plasma membrane traceable author statement (Zheng et al., 1995) neuron projection membrane inferred from biological aspect of ancestor with PANTHER:PTN000139573 (assigned by RefGenome) (Gaudet et al., 2010) plasma membrane inferred from sequence or structural similarity (assigned by UniProtKB) (Vinson et al., 1989, Adler et al., 1990)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
fz - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - VhaM8.9 anti tag coimmunoprecipitation, anti tag western blot (Buechling et al., 2010) fz - fax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - scf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) fz - wg inferred by author, affinity technology, fluorescence microscopy (Mulligan et al., 2012)
RNA-protein
Interacting group Assay References
fz - B52 electrophoretic mobility shift assay, autoradiography, systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing (Kim et al., 2003)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fz allele Gene References fz1 fy (Lee and Adler, 2002) in (Lee and Adler, 2002) Vang (Taylor et al., 1998) fz15 ft (Yang et al., 2002) fz2 (Chen and Struhl, 1999) fz19 aos (Strutt and Strutt, 2003) dsh (Strutt and Strutt, 2003) Ras85D (Strutt and Strutt, 2003) sty (Strutt and Strutt, 2003) fz20 aos (Strutt and Strutt, 2003) dsh (Strutt and Strutt, 2003) Ras85D (Strutt and Strutt, 2003) sty (Strutt and Strutt, 2003) fz21 fz::fz2 (Wu et al., 2004) in (Lee and Adler, 2002) fz23 dsh (Lee and Adler, 2002) fy (Lee and Adler, 2002) fz::fz2 (Wu et al., 2004) mwh (Lee and Adler, 2002) pk (Adler et al., 2000, Jenny et al., 2003) stan (Chae et al., 1999) Vang (Taylor et al., 1998) fz24 ds (Adler et al., 1998) fy (Lee and Adler, 2002) grh (Lee and Adler, 2004) in (Lee and Adler, 2002) Vang (Taylor et al., 1998) fz25 fy (Lee and Adler, 2002) pk (Adler et al., 2000) Vang (Taylor et al., 1998) fz30 numb (Bellaiche et al., 2001) pk (Jenny et al., 2003) fz37 ft (Yang et al., 2002) numb (Bellaiche et al., 2001) fz374-2360 fz2 (Kennerdell and Carthew, 1998) wg (Kennerdell and Carthew, 1998) fza.374-2360 fz2 (Kennerdell and Carthew, 1998) wg (Kennerdell and Carthew, 1998) fzdsRNA.A fz2 (Kennerdell and Carthew, 1998) fzHD21 in (Lee and Adler, 2002) fzhs.PP dsh (Lee and Adler, 2002) nkd (Rousset et al., 2001) stan (Chae et al., 1999) fzhs.sev Dl (Fanto and Mlodzik, 1999) N (Fanto and Mlodzik, 1999) fzI.hs ck (Winter et al., 2001) ds (Adler et al., 1998) dsh (Winter et al., 2001) Rho1 (Winter et al., 2001) rok (Winter et al., 2001) sqh (Winter et al., 2001) wg (Axelrod et al., 1998) zip (Winter et al., 2001) fzScer\UAS.cAa bsk (Strutt et al., 1997) dsh (Strutt et al., 1997) ft (Ma et al., 2003) kay (Ciapponi et al., 2001) Rho1 (Strutt et al., 1997) fzScer\UAS.cSa Gαo (Katanaev et al., 2005) fzScer\UAS.cZa wg (Moline et al., 2000) fzScer\UAS.N arm (Zhang and Carthew, 1998) dsh (Zhang and Carthew, 1998) fz2 (Zhang and Carthew, 1998) sgg (Zhang and Carthew, 1998) fzunspecified ds (Adler et al., 1998) Gαo (Katanaev et al., 2005) unspecified dco (Strutt et al., 2006, Klein et al., 2006) dgo (Jenny et al., 2005) dsh (Strutt et al., 2006) fy (Lee and Adler, 2002) fz2 (Bhanot et al., 1999, Povelones and Nusse, 2005) in (Lee and Adler, 2002) Jra (Weber et al., 2000) sha (Ren et al., 2006) tow (Chung et al., 2007) Vang (Taylor et al., 1998) wg (Zhang and Carthew, 1998) Wnt5 (Srahna et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69580 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001085 DroID - A comprehensive database of gene and protein interactions. • FBgn0001085 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45307 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18537
Orthologs
OrthoDB Orthologs (101) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6B5PQR Dipteran inclusive ortholog search EOG641QKN Insect inclusive ortholog search EOG6CZ9B0 Arthropod inclusive ortholog search EOG65QFVB Metazoa inclusive ortholog search EOG6QRVX3
Orthologs in Drosophila Species (EOG6B5PQR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\fz     Drosophila simulans   Dsim\GD14489 Y   Drosophila sechellia   Dsec\GM25464 Y   Drosophila erecta   Dere\GG15682 Y   Drosophila yakuba   Dyak\GE22012 Y   Drosophila ananassae   Dana\GF24601 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14615 Y   Drosophila persimilis   Dper\GL21009 Y   Drosophila willistoni   Dwil\GK12696 Y   Drosophila virilis   Dvir\fz Y   Drosophila mojavensis   Dmoj\GI11701 Y   Drosophila grimshawi   Dgri\GH17099 Y
Orthologs in non-Drosophila Dipterans (EOG641QKN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009986   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015190   Anopheles gambiae Malaria mosquito  Agam\GPRFZ1A   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007676
Orthologs in non-Dipteran Insects (EOG6CZ9B0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\fz   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008241   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16279   Atta cephalotes Leafcutter ant  Acep\ACEP16664   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17421   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12454   Linepithema humile Argentine ant  Lhum\LH21660   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11622   Solenopsis invicta Red fire ant  Sinv\SINV13229   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007768   Bombyx mori Silkmoth  Bmor\BGIBMGA005935   Pediculus humanus Human body louse  Phum\PHUM074510   Tribolium castaneum Red flour beetle  Tcas\Fz
Orthologs in non-Insect Arthropods (EOG65QFVB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\FZ1.2 Y Daphnia pulex Water flea  Dpux\Epm2aip1 Y Ixodes scapularis Deer tick  Isca\ISCW003177 Y Ixodes scapularis Deer tick  Isca\ISCW004077 Y
Orthologs in non-Arthropod Metazoa (EOG6QRVX3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mom-5 Y Caenorhabditis elegans Nematode  Cele\cfz-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008022gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004062gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022916gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003655gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023014gn Y Danio rerio Zebrafish  Drer\fzd2 Y Danio rerio Zebrafish  Drer\fzd8a Y Danio rerio Zebrafish  Drer\fzd10 Y Danio rerio Zebrafish  Drer\fzd9b Y Danio rerio Zebrafish  Drer\fzd4 Y Danio rerio Zebrafish  Drer\fzd9a Y Danio rerio Zebrafish  Drer\fzd7a Y Danio rerio Zebrafish  Drer\fzd8b Y Danio rerio Zebrafish  Drer\fzd3a Y Danio rerio Zebrafish  Drer\fzd3l Y Danio rerio Zebrafish  Drer\fzd6 Y Danio rerio Zebrafish  Drer\fzd1 Y Danio rerio Zebrafish  Drer\fzd7b Y Danio rerio Zebrafish  Drer\fzd8c Y Xenopus tropicalis Western clawed frog  Xtro\fzd8 Y Xenopus tropicalis Western clawed frog  Xtro\fzd3 Y Xenopus tropicalis Western clawed frog  Xtro\fzd2 Y Xenopus tropicalis Western clawed frog  Xtro\fzd5 Y Xenopus tropicalis Western clawed frog  Xtro\fzd7 Y Xenopus tropicalis Western clawed frog  Xtro\fzd4 Y Xenopus tropicalis Western clawed frog  Xtro\fzd9 Y Xenopus tropicalis Western clawed frog  Xtro\fzd10 Y Xenopus tropicalis Western clawed frog  Xtro\fzd6 Y Gallus gallus Domestic chicken  Ggal\FZD10 Y Gallus gallus Domestic chicken  Ggal\FZD7 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000008433 Y Gallus gallus Domestic chicken  Ggal\FZD1 Y Gallus gallus Domestic chicken  Ggal\FZD5 Y Gallus gallus Domestic chicken  Ggal\FZD3 Y Gallus gallus Domestic chicken  Ggal\FZD4 Y Gallus gallus Domestic chicken  Ggal\FZD6 Y Mus musculus House mouse  Mmus\Fzd2 Y Mus musculus House mouse  Mmus\Fzd3 Y Mus musculus House mouse  Mmus\Fzd9 Y Mus musculus House mouse  Mmus\Fzd7 Y Mus musculus House mouse  Mmus\Fzd8 Y Mus musculus House mouse  Mmus\Fzd10 Y Mus musculus House mouse  Mmus\Fzd5 Y Mus musculus House mouse  Mmus\Fzd4 Y Mus musculus House mouse  Mmus\Fzd6 Y Mus musculus House mouse  Mmus\Fzd1 Y Rattus norvegicus Norway rat  Rnor\Fzd1 Y Rattus norvegicus Norway rat  Rnor\Fzd8 Y Rattus norvegicus Norway rat  Rnor\Fzd6 Y Rattus norvegicus Norway rat  Rnor\Fzd4 Y Rattus norvegicus Norway rat  Rnor\Fzd5 Y Rattus norvegicus Norway rat  Rnor\Fzd2 Y Rattus norvegicus Norway rat  Rnor\Fzd9 Y Rattus norvegicus Norway rat  Rnor\LOC100360552 Y Homo sapiens Human  Hsap\FZD9 Y Homo sapiens Human  Hsap\FZD1 Y Homo sapiens Human  Hsap\FZD3 Y Homo sapiens Human  Hsap\FZD2 Y Homo sapiens Human  Hsap\FZD8 Y Homo sapiens Human  Hsap\FZD4 Y Homo sapiens Human  Hsap\FZD5 Y Homo sapiens Human  Hsap\FZD7 Y Homo sapiens Human  Hsap\FZD10 Y Homo sapiens Human  Hsap\FZD6 Y
Human Orthologs (10)
Gene OMIM HGNC Hsap\FZD9     Hsap\FZD1     Hsap\FZD3     Hsap\FZD2     Hsap\FZD8     Hsap\FZD4     Hsap\FZD5     Hsap\FZD7     Hsap\FZD10     Hsap\FZD6
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14489 Drosophila sechellia Dsec\GM25464 Drosophila erecta Dere\GG15682 Drosophila yakuba Dyak\GE22012 Drosophila ananassae Dana\GF24601 Drosophila pseudoobscura pseudoobscura Dpse\GA14615 Drosophila persimilis Dper\GL21009 Drosophila willistoni Dwil\GK12696 Drosophila virilis Dvir\fz Drosophila mojavensis Dmoj\GI11701 Drosophila grimshawi Dgri\GH17099
Stocks & Reagents
Stocks Listed in FlyBase ( 37 )
Bloomington	1676 fz1/TM1
Harvard	- P{XP}fzd01490 - PBac{PB}fzc03480 - PBac{PB}fzc05547 - PBac{RB}fze00573 - PBac{RB}fze01331 - PBac{RB}fze01695 - PBac{RB}fze01735 - PBac{RB}fze03401 - PBac{WH}fzf00972
Kyoto	106445 fz1/TM1
VDRC	v105493 P{KK108004}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR05B23 BACR16J19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 163 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32066
Other clones	DPiM_LD32066
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26617 LD29144 LD38941 LD38953 RE01518 RE03664 RE04833 RE05965 RE11131 RE14465 RE15538 RE16022 RE18378 RE20853 RE21516 RE22153 RE23067 RE23596 RE25174 RE28605 RE28833 RE30405 RE30435 RE32727 RE33186 RE35903 RE36064 RE37962 RE38164 RE39289 RE39584 RE40278 RE44386 RE47059 RE47067 RE48756 RE49724 RE50656 RE51516 RE51549 RE54152 RE57830 RE58606 RE61741 RE61761 RE62492 RE63081 RE63986 RE64431 RE64681 RE66612 RE66931 RE71946 RE72249 RE72635 RE74514 RH12094 RH16372 RH23606 RH47749 RH51988 RH55960 RH69361 SD03643
Other clones	17319 30414 31670 32162 38299 38608 58756 65877 66138 72966 77546 102010 106627 118979 120653 214251.47 214411.53 274519 274551 569179 569649 572769 CK01.3B.E8 CK01.16B.C1 CK01.18C.H12 CK01.29C.C12 CK01.62B.E4 CK01.87D.H2 CK01.102B.F4 CK01.104D.A10 CK01.106B.C7 CK01.114D.G5 CK01.168D.E10 CK01.170B.E3 Dmel_dig_011364_0677_0491 EK008037 EK026044 EK038909 EK049541 EK050038 EK069361 EK086154 EK086802 EK088712 EK104418 EK129362 EK139515 EK142454 EK145906 EK169208 EK173059 EK174663 EK181859 EK208447 EK224224 EK238353 EK240353 EK242553 EK302505 EN10663 EN14662 EN15327 EN17030 EP07727 EP12151 FGC029F10 FGM224F02 RE18640 RP004092395 RP004153451 RP004156430 RP004175427 RP004183017 RP004189187 RP004194103 RP004194881 RP004207252 RP004209825 RP004225630 RP004231976 RP004233948 RP004236642 RP004250301 RP004252926 RP004256292 RP004264022 RP004269319 RP004270404 RP004339057 RP004377661 RP004394749 RP004404372 RP004420062 RP004422225 RP004425647 RP004510932 RP004518821
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001085 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45307
Antibody Information
	monoclonal, polyclonal (Park et al., 1994)
Other Information
Discoverer
	Bridges, 18th Feb. 1938.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: fz CG3646 (Bayraktaroglu, 1999.11)
Source for database merge of	Source for merge of: fz CG3646 CG17697 (Bayraktaroglu, 2000.4.17)
Additional comments	Most alleles fit into a hypomorphic to amorphic series with many hemizygotes displaying a more severe phenotype than homozygotes.
Other Comments
	Mutations in fz influence the arrangement of ommatidia at the micro-scale but have no effect on the ommatidium nano-scale structure. (Kryuchkov et al., 2011) fz is required for normal salivary gland migration in the embryo. It is required in the second phase of salivary gland migration, as the gland moves posteriorly within the embryo. (Harris and Beckendorf, 2007) Clonal analysis indicates that the ds/ft system and the stan/fz system act independently to confer planar cell polarity in the adult abdomen; each system confers and propagates polarity and can do so in the absence of the other. (Casal et al., 2006) dsRNA made from templates generated with primers directed against this gene. (Klein et al., 2006) fz is transported to the distal sides of developing wing blade cells during pupal stages by transport in microtubules associated endosomes. (Shimada et al., 2006) Molecular analyses suggest that the cysteine-rich domain of fz recruits wg, and bound wg interacts with the membrane portion of the receptor to initiate signalling. RNAi knockdown experiments show that fz and wg also require the receptor Arr1 to initiate arm signalling. (Povelones and Nusse, 2005) The wg morphogen gradient appears to be established by the cooperative action of fz and Heparan Sulfate Proteoglycan receptors. (Baeg et al., 2004) Vang acts together with fz and stan to mediate apicolateral recruitment of planar polarity proteins including dsh and pk. (Bastock et al., 2003) The Vang/pk complex appears to modulate fz/dsh activity, resulting in a symmetry-breaking step during polarity signalling. (Jenny et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The fz feedback loop, acting to propagate polarity from cell to cell, is sufficient to align planar polarity of cells in the wing. (Ma et al., 2003) in and fy are needed in cells receiving and responding to a fz dependent intercellular signal. Genetic analysis is not consistent with fz-like class of genes fz, pk, Vang, stan and dsh acting simply as positive or negative regulators of in and fy. (Lee and Adler, 2002) Mutations in fz-like class of genes fz, pk, Vang, stan and dsh act as strong enhancers of weak in or fy phenotypes. In the wing as in the abdomen in and fy are epistatic to fz as double mutants resemble in and fy and not fz. fz and Vang show complementary domineering nonautonomy in the wing and abdomen. The domineering nonautonomy in the abdomen of fz clones is not blocked by cells also being mutant for in. In the eye fz is epistatic to in and fy. In terms of the wing eversion phenotype of fz, in and fy appear to be epistatic to fz. (Lee and Adler, 2002) fz play an important role in the regulation planar polarity in the compound eye. (Yang et al., 2002) fz participates in the pIIa vs pIIb fate decision in the external sensory organ lineage. (Bellaiche et al., 2001) Area matching Drosophila Frizzled gene Acc. No. X54648. (Davies, 2001.3.15) the asymmetric localisation of fz in adult wing cells may be an instructive cue in the determination of cell polarity. (Strutt, 2001) Mutant embryos lacking maternal fz, zygotic fz and zygotic fz2 show defects in the epidermis, CNS, heart and midgut that are indistinguishable from the defects observed for wg mutants. (Bhanot et al., 1999) fz and fz2 function as redundant receptors for wg during embryonic development. (Bhanot et al., 1999) fz and fz2 are required during embryogenesis to maintain epidermal en and wg expression. (Bhanot et al., 1999) fz and fz2 are functionally redundant and act as the primary receptors for wg protein. (Chen and Struhl, 1999) wg signal transduction is abolished in virtually all cells lacking both fz and fz2 in embryos as well as in imaginal discs. (Chen and Struhl, 1999) fz appears to function in the wg pathway to pattern sensory organs. (Lu et al., 1999) Wing cells appear acquire proximo-distal polarity by way of the fz-dependant boundary localisation of stan. (Usui et al., 1999) Mutations in ds cause a tissue polarity phenotype in the wing by altering the direction of fz signaling. (Adler et al., 1998) fz and fz2 play a partially redundant role in wg signalling during neurogenesis. (Bhat, 1998) dsh functions in both fz and fz2 signalling, but distinct dsh protein domains feature in the two pathways. (Boutros et al., 1998) fz-mediated signalling provides polarity information to pI, specifying the orientation of mitotic spindles. The orientations of the pIIa and pIIb divisions are independent of fz signalling and are instead defined by the axis of the previous pI division. (Gho and Schweisguth, 1998) fz and fz2 function redundantly, downstream of wg and upstream of sgg, in the wg signalling pathway in the establishment of segment polarity in the embryo. (Kennerdell and Carthew, 1998) The Vang gene product is essential for fz signalling. (Taylor et al., 1998) fz2 and not fz acts in the wg signalling pathway for wing margin development. (Zhang and Carthew, 1998) A single dominant negative form of fz or fz2 can block more than one type of Wnt signalling pathway implying that truncated proteins of the Fz family lose some aspect of signaling specificity. (Zhang and Carthew, 1998) Cells can assess the level of fz protein on neighbouring cells and use this as a source of polarity information. (Adler et al., 1997) Mutants do not exhibit defects in the denticle belt of hairs of the larvae. (Dickinson and Thatcher, 1997) Genetic interactions indicate that Rho1 has a role in signalling mediated by fz. (Strutt et al., 1997) Planar polarity phenotypes of loss of function and overexpression of fz in the developing eye is studied, the phenotype is almost identical to loss of function or overexpression of dsh, or overexpression of sgg. Overexpression of fz in the developing eye has a potent polarizing effect on the retinal epithelium. (Tomlinson et al., 1997) Cell nonautonomous fz alleles are associated with mutations that alter amino acids in all regions of the encoded protein. The four cell autonomous mutations fall in a proline residue in the presumptive first cytoplasmic loop of the protein. Comparison of fz with Dvir\fz revealed that the protein is unusually well conserved: in the putative cytoplasmic domains the two proteins are identical. (Jones et al., 1996) dsh function is required for endogenous fz activity. fz activity is directly proportional to dsh gene dosage. (Krasnow et al., 1995) Loss of fz function affects the rotation and breaking of symmetry of photoreceptor cell preclusters. Clonal analysis reveals that fz acts non-autonomously. Mitotic clones affect the polarity of neighboring wild-type ommatidia distal, but not proximal to the equatorial midline, suggesting that fz might mediate a signal in the developing eye transmitted bidirectionally from the equator to the opposite poles. (Zheng and Carthew, 1995) The function of fz is required in the establishment of mirror-image symmetry about the equatorial midline in the compound eye. (Zheng and Carthew, 1995) Mutant phenotype suggests fz is required for the correct rotational direction, the precise 90o turn and the correct asymmetry arrangement of R3 and R4 cells. fz is not required for the synchronous movement of photoreceptor cells within individual clusters since photoreceptor cells in each fz mutant ommatidium still rotate as a unit. Mosaic analysis demonstrates fz has non-autonomous effects on eye development. Double mutant analysis suggests that nmo and fz functional synergistically in directing ommatidial rotation. (Zheng et al., 1995) A cold sensitive allele of fz has been isolated and study of the mutant argues that fz has a regulatory function in specifying where the prehair forms, but has no role in the actual morphogenesis of the prehair. (Adler et al., 1994) Comparisons between fz and in alleles reveals that at equivalent fractions of the wing showing abnormal polarity, in mutant wings have many fold more multiple hair cells than fz mutant wings. (Krasnow and Adler, 1994) The longer, more abundant form of the two mRNA variants transcribed from fz encodes both the cell autonomous and non-autonomous functions of fz that have been revealed in mosaic experiments. (Krasnow and Adler, 1994) fz protein is an integral membrane protein with an odd number of transmembrane domains. Immunostaining of pupal wings reveals that the fz protein is evenly distributed across the wing and concentrates in the apical region of the pupal wing cells. (Park et al., 1994) Western blot analysis of fz protein accumulation in wing discs and pupal wings demonstrates fz is expressed in all regions of the epidermis before, during and after the fz cold sensitive period and prehair morphogenesis. fz function is not required for normal fz expression and mutations in other tissue polarity genes does not alter the amount or size of fz protein. (Park et al., 1994) Two similar proteins identified in rat. (Chan et al., 1992) Cloning and characterisation of the fz locus has shown that this locus is very large (over 90kb) and probably encodes an integral membrane protein. (Adler et al., 1990) Hairs on thorax directed irregularly toward midline. Thoracic bristles also inturned and often wavy. Postverticals may turn outward. Hairs on wing edge and feet nearly erect; trichomes on wings of flies carrying weaker alleles tend to form swirls rather than lying parallel to one another and pointing distally; stronger alleles can cause random orientation of trichomes. Polarity of chaetae deranged in characteristic ways on wings, notum, halteres, legs, tergites and sternites; fz M+ clones in M/+ wings cause derangement of polarity in M/+ cells surrounding clone (Gubb and Garcia-Bellido, 1982). In a wild-type background clones of wing cells homozygous for fz alleles that cause eye roughening, but not of those without effect on eye texture, cause adjacent normal trichomes in regions distal, anterior and posterior, but not proximal to the clone, to orient toward the clone rather than distally as they normally do; no effect on trichomes on opposite surface of the wing (Vinson and Adler, 1987). Wing may be reduced. A low level of doubling of trichomes and splitting of chaetae observed. Sex combs may be irregular. Most alleles cause eyes to be rough Extra leg joints tend to form as mirror-image duplications proximal to the normal joints on tarsal segments one to four. Also polarities of bristles, hairs, and bracts on legs abnormal (Held, Duarte and Derakhshanian, 1986).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080073 NM_168587 NM_001274907 RefSeq (Proteins) • NP_524812 NP_729970 NP_001261836 DDBJ / EMBL / GenBank • AA951534 AAF49746 AAK93232 AAN11810 AGB94529 AW943116 AX093877 AY051808 AZ933376 CAA38458 CAA38459 CAA38460 CAA38461 CL868592 CZ468672 CZ470087 CZ472260 CZ478448 CZ479142 CZ479504 CZ479505 CZ479546 CZ481175 CZ481176 CZ483452 CZ489475 CZ489476 CZ489683 CZ490629 CZ490630 X54646 X54647 X54648 X54649 X54650 X54651 X54652 Entrez Gene - A searchable database of RefSeq genes. • 45307 UniProtKB/Swiss-Prot • P18537
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GPCR, family 2-like (IPR017981) Frizzled protein (IPR000539) Frizzled/secreted frizzled-related protein (IPR015526) Frizzled domain (IPR020067)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69580 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001085 DroID - A comprehensive database of gene and protein interactions. • FBgn0001085 DRSC - Results from RNAi screens. • FBgn0001085 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001085 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17697-RA;CG17697-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001085 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 90585 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45307 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/frizzled.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45307 modMine - Data generated by the modENCODE project. • FBgn0001085 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P18537
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	CG3646 (Norga et al., 2003, ) CG17697 (Holloway et al., 2008, Carrera et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1) DFz (Wehrli et al., 2002, Wehrli et al., 2001, Hermle et al., 2010) DFz1 (He, 2003, Eroglu et al., 2002) DFZ1 (Rehn et al., 1998) Dfz1 (Yanagawa et al., 1998, Wang et al., 1996, Perrimon, 1996, Bovolenta et al., 2006, Schweizer and Varmus, 2003) Dm Fz1 (Konikoff et al., 2010) frz (Novak and Dedhar, 1999, Gubb et al., 1999, Ayroles et al., 2009) Frz (Nagaraj and Banerjee, 2009) fz (Edwards et al., 2006, Lawrence et al., 2004, DasGupta et al., 2005, Lawrence et al., 2007, Ren et al., 2006, Tyler et al., 2007, Rives et al., 2006, Strutt et al., 2006, Strutt and Strutt, 2005, Winter et al., 2001, Furlong, 2005, Bartscherer et al., 2006, Mirkovic and Mlodzik, 2006, Madder and Strutt, 2007, Gordon and Nusse, 2006, Todi et al., 2008, Aerts et al., 2007, Holloway et al., 2008, Chung et al., 2007, Classen et al., 2005, Olguín et al., 2011, Walters et al., 2006, Goo et al., 1999, Mirkovic et al., 2011, Seto and Bellen, 2006, Casal et al., 2006, Ma et al., 2006, Jenny et al., 2005, Wu et al., 2008, Shimada et al., 2006, Strutt, 2001, Lim et al., 2005, Fanto and McNeill, 2004, Fabre et al., 2008, Cordero and Cagan, 2010, Harris and Beckendorf, 2007, Le Garrec et al., 2006, Zhu, 2011, Sinenko et al., 2010, Vincent et al., 2011, Cho et al., 2011, David et al., 2005, Rawls et al., 2007, Kankel et al., 2007, Hermle et al., 2013, Shimizu et al., 2011, Singh et al., 2010, Zhu, 2009, Jungreis et al., 2011, Toku et al., 2011, del Alamo and Mlodzik, 2006, Wu and Mlodzik, 2008, Bastock and Strutt, 2007, Grillenzoni et al., 2007, Strutt and Strutt, 2007, Chen et al., 2008, Strutt and Warrington, 2008, Bhat, 2007, Fiehler and Wolff, 2007, Fiehler and Wolff, 2008, Weber et al., 2008, Price et al., 2006, Piddini and Vincent, 2009, Strutt and Strutt, 2008, Steinel and Whitington, 2009, Cabernard and Affolter, 2005, Lin et al., 2008, Ayroles et al., 2009, Simons et al., 2009, He and Adler, 2002, Lipatov et al., 2005, Gomes et al., 2009, Yan et al., 2008, Carrera et al., 2008, Blanco et al., 2009, Sinenko et al., 2009, Seugnet et al., 2009, Zeitlinger et al., 2007, Jaiswal et al., 2006, Fetting et al., 2009, Yan et al., 2009, Burak and Shraiman, 2009, DasGupta et al., 2007, Chung et al., 2009, Doyle et al., 2008, Li et al., 2010, Ho et al., 2010, Hermle et al., 2010, Pataki et al., 2010, Lu et al., 2010, Sato et al., 2006, Harumoto et al., 2010, Beltran et al., 2007, Repiso et al., 2010, Hazelett et al., 2009, Cho and Fischer, 2011, Silver et al., 2007, Franke et al., 2010, Olguín et al., 2011, Kryuchkov et al., 2011, Matsubara et al., 2011, Cernilogar et al., 2011, Brittle et al., 2012, Carreira et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Kuroda et al., 2012, Gault et al., 2012, Capilla et al., 2012, Tan et al., 2012, Weber et al., 2012) Fz (Kockel et al., 2001, Torban et al., 2004, Baeg et al., 2003, Wu et al., 2000, Rulifson et al., 2000, Kudoh, 1999, Humbert et al., 2006, Wu and Mlodzik, 2007, Chin and Yeston, 2006, Klein et al., 2006, Quaiser, 2006, He and Axelrod, 2006, Blair et al., 2006, Segalen et al., 2007, Halbleib and Nelson, 2006, Mouri et al., 2012, Jenny et al., 2008, Sánchez et al., 2008, Jankovics and Brunner, 2006, Walthall et al., 2007, Ma et al., 2008, Kopein and Katanaev, 2009, Djiane and Mlodzik, 2010, Buechling et al., 2010, Hermle et al., 2010, Mottola et al., 2010, Ségalen et al., 2010, Buechling et al., 2011, Yanfeng et al., 2011, Weber et al., 2012, Singh and Mlodzik, 2012, Tan et al., 2012) FZ (Tree et al., 2000, Dawes-Hoang and Wieschaus, 2001) fz1 (Anonymous, 2004, Lum et al., 2003, Djiane et al., 2005) Fz1 (Wu et al., 2004, Johnson et al., 2000, Perrimon and Nusse, 1998, Chaudhary and Strutt, 2007, Djiane and Mlodzik, 2010) fz1 (Baena-Lopez and Garcia-Bellido, 2006)
Name Synonym	frazzled (Kryuchkov et al., 2011) frizzled (Edwards et al., 2006, Lee and Adler, 2002, Lawrence et al., 2007, Strutt, 2005, Leptin, 2005, Burnette et al., 2005, Strutt and Strutt, 2005, Winter et al., 2001, Sambandan et al., 2006, Seto and Bellen, 2006, Fanto and McNeill, 2004, Harris and Beckendorf, 2007, Le Garrec et al., 2006, Zeitouni et al., 2007, Zhu, 2011, Kankel et al., 2007, Shimizu et al., 2011, Fiehler and Wolff, 2007, He and Adler, 2002, Fetting et al., 2009, Pataki et al., 2010, Lu et al., 2010, Curtis et al., 2007, Silver et al., 2007, Franke et al., 2010, Sinenko et al., 2010) Frizzled (Pandur et al., 2002, Djiane et al., 2006, Wu and Mlodzik, 2007, Heeg-Truesdell, 2006, Quaiser, 2006, Stadeli, 2006, Blair et al., 2006, Warrington and Strutt, 2007, Anonymous, 2006, Tountas and Fortini, 2007, Todi et al., 2008, Srahna et al., 2006, Coudreuse and Korswagen, 2007, Wu et al., 2008, Lim et al., 2005, Dawes-Hoang and Wieschaus, 2001, Marques, 2005, Hariharan, 2006, Lecuit and Le Goff, 2007, Kerszberg and Wolpert, 2007, Voas and Rebay, 2004, David et al., 2005, Strutt and Strutt, 2007, Chen et al., 2008, Bhat, 2007, Price et al., 2006, Walthall et al., 2007, Strutt and Strutt, 2008, Lin et al., 2008, Gomes et al., 2009, Blanco et al., 2009, Kopein and Katanaev, 2009, Li et al., 2010, Hermle et al., 2010, Mottola et al., 2010, Ségalen et al., 2010, Gault et al., 2012, Singh and Mlodzik, 2012, Tan et al., 2012, Weber et al., 2012) frizzled 1 (Zahner et al., 2000) Frizzled 1 (Johnson et al., 2000, Eroglu et al., 2002) Frizzled1 (Martinez Arias, 2005) frizzled1 (Baena-Lopez and Garcia-Bellido, 2006)
Secondary FlyBase IDs
	FBgn0036418 FBgn0036420
References ( 630 )
Generate a list of	All references relating to this gene ( 630 )
List References by type	Research paper  ( 287 ) Supplementary material  ( 11 ) Review  ( 193 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 96 ) FlyBase analysis  ( 2 ) Conference report  ( 11 ) Stock list  ( 2 ) Curated genome annotation  ( 3 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 2 ) Letter  ( 1 )
Recent research papers ( 32 )
	Hermle et al., 2013, EMBO J. 32(2): 245--259 Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. [FBrf0220613] Pitsouli and Perrimon, 2013, Sci. Signal. 6(263): ra12 The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. [FBrf0220848] Warrington et al., 2013, Development 140(5): 1045--1054 The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2. [FBrf0220829] Brittle et al., 2012, Curr. Biol. 22(10): 907--914 Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous. [FBrf0219618] Capilla et al., 2012, Development 139(14): 2584--2593 Planar cell polarity controls directional Notch signaling in the Drosophila leg. [FBrf0218695] Gault et al., 2012, J. Cell Biol. 196(5): 605--621 Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. [FBrf0217630] Kuroda et al., 2012, Mech. Dev. 128(11-12): 625--639 Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut. [FBrf0217619] Mouri et al., 2012, Genes Cells 17(6): 509--524 Cohesin controls planar cell polarity by regulating the level of the seven-pass transmembrane cadherin Flamingo. [FBrf0218403] Mulligan et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(2): 370--377 Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. [FBrf0217131] Ng, 2012, Development 139(1): 165--177 Wnt/PCP proteins regulate stereotyped axon branch extension in Drosophila. [FBrf0216855] Singh and Mlodzik, 2012, Dev. Cell 23(1): 82--96 Hibris, a Drosophila Nephrin Homolog, Is Required for Presenilin-Mediated Notch and APP-like Cleavages. [FBrf0218978] Struhl et al., 2012, Development 139(19): 3665--3674 Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity. [FBrf0220280] Strutt et al., 2012, Genetics 192(4): 1295--1313 Structure-Function Dissection of the Frizzled Receptor in Drosophila melanogaster Suggests Different Mechanisms of Action in Planar Polarity and Canonical Wnt Signaling. [FBrf0220129] Tan et al., 2012, PLoS Genet. 8(5): e1002681 MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. [FBrf0218227] Tauc et al., 2012, genesis 50(6): 466--481 A role for Drosophila Wnt-4 in heart development. [FBrf0218607] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Behura et al., 2011, PLoS ONE 6(7): e21504 Comparative Genomic Analysis of Drosophila melanogaster and Vector Mosquito Developmental Genes. [FBrf0214308] Buechling et al., 2011, EMBO Rep. 12(12): 1265--1272 p24 proteins are required for secretion of Wnt ligands. [FBrf0216831] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Cernilogar et al., 2011, Nature 480(7377): 391--395 Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila. [FBrf0216979] Cho et al., 2011, PLoS ONE 6(7): e22703 Wolbachia bacteria reside in host Golgi-related vesicles whose position is regulated by polarity proteins. [FBrf0214605] Cho and Fischer, 2011, Development 138(7): 1349--1359 Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. [FBrf0213208] Donoughe and Dinardo, 2011, Development 138(13): 2751--2759 dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis. [FBrf0213896] Kryuchkov et al., 2011, PLoS ONE 6(7): e22237 Analysis of micro- and nano-structures of the corneal surface of Drosophila and its mutants by atomic force microscopy and optical diffraction. [FBrf0214595] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Olguín et al., 2011, Curr. Biol. 21(3): 236--242 Intertissue mechanical stress affects frizzled-mediated planar cell polarity in the Drosophila notum epidermis. [FBrf0212947] Shimizu et al., 2011, J. Neurosci. 31(13): 4944--4954 The wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron. [FBrf0213382] Strutt et al., 2011, Dev. Cell 20(4): 511--525 Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains. [FBrf0214246] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vincent et al., 2011, Dev. Cell 21(2): 366--374 Steep differences in wingless signaling trigger myc-independent competitive cell interactions. [FBrf0214665] Yanfeng et al., 2011, Dev. Biol. 360(1): 132--142 Functional dissection of phosphorylation of Disheveled in Drosophila. [FBrf0216602] Zhu, 2011, J. Theor. Biol. 268(1): 131--140 Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control. [FBrf0212388] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...