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Gene Dmel\fzy

General Information
Symbol	Dmel\fzy	Species	D. melanogaster
Name	fizzy	Annotation symbol	CG4274
Feature type	protein_coding_gene	FlyBase ID	FBgn0001086
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	cdc20, Cdc20/Fizzy, BG:DS02740.14
Genomic Location
Chromosome (arm)	2L	Recombination map	2-51
Cytogenetic map	35F1-35F1	Sequence location	2L:16,310,929..16,313,097 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene fizzy is referred to in FlyBase by the symbol Dmel\fzy (CG4274, FBgn0001086). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; female meiosis II; cyclin catabolic process; cellular process; female meiosis I; mitosis; cell cycle; protein catabolic process; neurogenesis; phagocytosis, engulfment. 21 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; embryonic ventral epidermis; mitotic cell cycle; embryonic ventral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1636341_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of fzy. Gene sequence location is 2L:16310929..16313097.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	fzy: fizzy Homozygous lethal; ventral outside and central nervous system degenerate.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA03534 BKN21403
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35F1-35F1   Limits computationally determined from genome sequence between P{lacW}heixk11403&P{lacW}heixk12401 and P{EP}fzyEP1028&P{lacW}mRpL4k14608
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35F8-35F11   (determined by in situ hybridisation)   (Ashburner et al., 1999)
Experimentally Determined Recombination Data
Location	2-51 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fzy for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fzy-RA FBtr0080833  NM_058153   2023   526
Additional Transcript Data & Comments
Reported size (kB)	1.9 (longest cDNA) (Dawson et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fzy-PA   FBpp0080391   57.1   526   8.98     NP_477501   AAF53523
Additional Polypeptide Data & Comments
Reported size (kDa)	526 (aa); 59 (kD observed) (Dawson et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141574   AA264915   AA390445   AA392353   AA438434   AA438914   AA439457   AA538619   AA695117   AA803324   AA816831   AA817243   AA817370   AA820125   AA820352   AA820465   AA820679   AA820827   AA942626   AA950658   AA950942   AA978824   AA979308   AA990693   AE014134 AAF53523   AC092398   AI064676   AI512109   AI514603   AI515743   AI516050   AI516631   AI518579   AI518784   AI519643   AI543056   AI546129   AI546627   AQ025016   BF488493   BF494930   BF504029   BG634608   BG636302   BG638603   BI163785   BI164268   BI164510   BI164693   BI166190   BI166437   BI166471   BI169264   BI170765   BI214617   BI215912   BI227625   BI229836   BI232469   BI233229   BI234085   BI236265   BI239982   BI242071   BI357781   BI357793   BI358465   BI365094   BI366209   BI368407   BI368909   BI482640   BI483063   BI483541   BI638512   BI641119   BI641877   BQ102863   BQ102866   BT010249 AAQ23567   BT056243   CA806324   CK604914   CK604915   CK657875   CO274521   CO275399   CO282072   CO296501   EC060615   EC087186   EC209544   EC213931   EC222433   EV584729   GH750231   GH752526   GH753117   GH753614   GH756179   GH758431   GH760245   GH771889   GH779964   GH781638   GH789081   GH796138   GH803181   GH803867   GH805845   GH811144   GH813516   GH821473   GH823595   GH826373   GH826754   GH836473   GH837846   GH840843   GH854768   GH859422   GH863544   GH873178   GH874969   GH883800   GH884496   GH890817   GH891685   GH892514   GH892770   GH895540   GH904693   GH905325   GH916313   GH923530   GH924480   GH927953   GH928385   GH929602   GH933618   U22419 AAA83150
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24044 Q6NR32
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 10   organism | ubiquitous   (Dawson et al., 1995) embryonic stage 11   presumptive embryonic/larval central nervous system | presumptive   (Dawson et al., 1995) embryonic stage 14   neuroblast | restricted   (Dawson et al., 1995) ganglion mother cell | restricted   (Dawson et al., 1995)
Additional Descriptive Data
	fzy protein is ubiquitous in stage 5 to 10 embryos, but its expression is restricted to proliferating cells after stage 11. The highest level of fzy protein in stage 11 embryos is found in the CNS precursors. At stage 14, the neuroblasts and ganglion mother cells at the edges of the ventral nerve cord and the brain lobes contain fzy protein. (Dawson et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001086    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001086 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001086 expression level Developmental Stage   Expression Level embryo 00-02hr    11135 embryo 02-04hr    19069 embryo 04-06hr    25073 embryo 06-08hr    16502 embryo 08-10hr    11866 embryo 10-12hr    5203 embryo 12-14hr    3062 embryo 14-16hr    2739 embryo 16-18hr    2071 embryo 18-20hr    1043 embryo 20-22hr    3017 embryo 22-24hr    2824 larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9    1459 white prepupae new    1337 white prepupae 12hr    1943 white prepupae 24hr    2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day    1468 adult female 05day    3551 adult female 30day    3744 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11135) embryo 02-04hr  (19069) embryo 04-06hr  (25073) embryo 06-08hr  (16502) embryo 08-10hr  (11866) embryo 10-12hr  (5203) embryo 12-14hr  (3062) embryo 14-16hr  (2739) embryo 16-18hr  (2071) embryo 18-20hr  (1043) embryo 20-22hr  (3017) embryo 22-24hr  (2824) larva L1  (114) larva L2  (162) larva L3 12hr old  (247) larva L3 puffstage 1-2  (800) larva L3 puffstage 3-6  (1057) larva L3 puffstage 7-9  (1459) white prepupae new  (1337) white prepupae 12hr  (1943) white prepupae 24hr  (2015) pupae 2d postWPP  (936) pupae 3d postWPP  (462) pupae 4d postWPP  (454) adult male 01day  (624) adult male 05day  (988) adult male 30day  (821) adult female 01day  (1468) adult female 05day  (3551) adult female 30day  (3744) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11135) embryo 02-04hr  (19069) embryo 04-06hr  (25073) embryo 06-08hr  (16502) embryo 08-10hr  (11866) embryo 10-12hr  (5203) embryo 12-14hr  (3062) embryo 14-16hr  (2739) embryo 16-18hr  (2071) embryo 18-20hr    1043 embryo 20-22hr  (3017) embryo 22-24hr  (2824) larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9  1459 white prepupae new    1337 white prepupae 12hr  (1943) white prepupae 24hr  (2015) pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day  1468 adult female 05day  (3551) adult female 30day  (3744) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11135) embryo 02-04hr  (19069) embryo 04-06hr  (25073) embryo 06-08hr  (16502) embryo 08-10hr  (11866) embryo 10-12hr    5203 embryo 12-14hr    3062 embryo 14-16hr    2739 embryo 16-18hr    2071 embryo 18-20hr    1043 embryo 20-22hr    3017 embryo 22-24hr    2824 larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9    1459 white prepupae new    1337 white prepupae 12hr    1943 white prepupae 24hr    2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day    1468 adult female 05day    3551 adult female 30day    3744 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11135 embryo 02-04hr    19069 embryo 04-06hr    25073 embryo 06-08hr    16502 embryo 08-10hr    11866 embryo 10-12hr    5203 embryo 12-14hr    3062 embryo 14-16hr    2739 embryo 16-18hr    2071 embryo 18-20hr    1043 embryo 20-22hr    3017 embryo 22-24hr    2824 larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9    1459 white prepupae new    1337 white prepupae 12hr    1943 white prepupae 24hr    2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day    1468 adult female 05day    3551 adult female 30day    3744 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001086 expression level Developmental Stage   Expression Level embryo 00-02hr    11135 embryo 02-04hr    19069 embryo 04-06hr    25073 embryo 06-08hr    16502 embryo 08-10hr    11866 embryo 10-12hr    5203 embryo 12-14hr    3062 embryo 14-16hr    2739 embryo 16-18hr    2071 embryo 18-20hr    1043 embryo 20-22hr    3017 embryo 22-24hr    2824 larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9    1459 white prepupae new    1337 white prepupae 12hr    1943 white prepupae 24hr    2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day    1468 adult female 05day    3551 adult female 30day    3744 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11135) embryo 02-04hr  (19069) embryo 04-06hr  (25073) embryo 06-08hr  (16502) embryo 08-10hr  (11866) embryo 10-12hr  (5203) embryo 12-14hr  (3062) embryo 14-16hr  (2739) embryo 16-18hr  (2071) embryo 18-20hr  (1043) embryo 20-22hr  (3017) embryo 22-24hr  (2824) larva L1  114 larva L2  (162) larva L3 12hr old  (247) larva L3 puffstage 1-2  (800) larva L3 puffstage 3-6  (1057) larva L3 puffstage 7-9  (1459) white prepupae new  (1337) white prepupae 12hr  (1943) white prepupae 24hr  (2015) pupae 2d postWPP  (936) pupae 3d postWPP  (462) pupae 4d postWPP  (454) adult male 01day  (624) adult male 05day  (988) adult male 30day  (821) adult female 01day  (1468) adult female 05day  (3551) adult female 30day  (3744) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11135) embryo 02-04hr  (19069) embryo 04-06hr  (25073) embryo 06-08hr  (16502) embryo 08-10hr  (11866) embryo 10-12hr  (5203) embryo 12-14hr  (3062) embryo 14-16hr  (2739) embryo 16-18hr  2071 embryo 18-20hr    1043 embryo 20-22hr  (3017) embryo 22-24hr  (2824) larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9  1459 white prepupae new    1337 white prepupae 12hr  1943 white prepupae 24hr  2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day  1468 adult female 05day  (3551) adult female 30day  (3744) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11135 embryo 02-04hr  19069 embryo 04-06hr  (25073) embryo 06-08hr  16502 embryo 08-10hr  11866 embryo 10-12hr    5203 embryo 12-14hr    3062 embryo 14-16hr    2739 embryo 16-18hr    2071 embryo 18-20hr    1043 embryo 20-22hr    3017 embryo 22-24hr    2824 larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9    1459 white prepupae new    1337 white prepupae 12hr    1943 white prepupae 24hr    2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day    1468 adult female 05day    3551 adult female 30day    3744 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11135 embryo 02-04hr    19069 embryo 04-06hr    25073 embryo 06-08hr    16502 embryo 08-10hr    11866 embryo 10-12hr    5203 embryo 12-14hr    3062 embryo 14-16hr    2739 embryo 16-18hr    2071 embryo 18-20hr    1043 embryo 20-22hr    3017 embryo 22-24hr    2824 larva L1    114 larva L2    162 larva L3 12hr old    247 larva L3 puffstage 1-2    800 larva L3 puffstage 3-6    1057 larva L3 puffstage 7-9    1459 white prepupae new    1337 white prepupae 12hr    1943 white prepupae 24hr    2015 pupae 2d postWPP    936 pupae 3d postWPP    462 pupae 4d postWPP    454 adult male 01day    624 adult male 05day    988 adult male 30day    821 adult female 01day    1468 adult female 05day    3551 adult female 30day    3744 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001086    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001086 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001086 expression level Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary  (596.2) Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001086 expression level Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary  596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    318.875 Larval Midgut no informative data Larval Hindgut    11.9 Larval Malpighian Tubules    1.5 Larval Fat Body    52.9 Larval Salivary Gland    4.8 Larval Trachea    58.425 Larval Carcass    37.65 Adult Head    0.6 Adult Eye    0.725 Adult Brain    1.1 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    4.6 Adult Midgut    6.8 Adult Hindgut    1.2 Adult Malpighian Tubules    3.1 Adult Fat Body    0.5 Adult Salivary Gland    1.1 Adult Heart    1.725 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    596.2 Adult Testis    203 Adult Male Accessory Gland    0.6 Adult Carcass    6.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    0.6   NA  Eye    0.725   NA  Brain    1.1   318.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    0.9   NA  Crop    4.6   no informative data  Midgut    6.8   11.9  Hindgut    1.2   1.5  Malpighian Tubules    3.1   52.9  Fat Body    0.5   4.8  Salivary Gland    1.1   NA  Heart    1.725   58.425  Trachea    NA   NA  VirginFemale Spermatheca    1.3   NA  InseminatedFemale Spermatheca    0.8   NA  Ovary    596.2   NA  Testis    203   NA  Male Accessory Gland    0.6   37.65  Carcass    6.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001086 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • LD44795;CG4274-RA;Stencil:U:4573297:4567654:GENSCAN FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for fzy Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 fzyGD11268 lethal, with Scer\GAL4pnr-MD237 fzyGD11268 lethal | embryonic stage | recessive fzy1 fzy2 fzy3 fzy6 fzyID fzyunspecified lethal | pupal stage, with Scer\GAL4ptc-559.1 fzyScer\UAS.cSa lethal | pupal stage | heat sensitive, with Scer\GAL4en-e16E fzyScer\UAS.cSa lethal | recessive | heat sensitive fzy4 fzy5 fzy6 fzy7 Sterility Allele female sterile | recessive fzy1 fzy6 fzyID Other Phenotypes Allele meiotic cell cycle defective | heat sensitive (with fzy6) fzy7 meiotic cell cycle defective | heat sensitive (with fzy7) fzy6 neuroanatomy defective | larval stage, with Scer\GAL41407 fzyGD11268 visible, with Scer\GAL4en-e16E fzyScer\UAS.cSa visible, with Scer\GAL4pnr-MD237 fzyGD11268 wild-type fzytDa Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 fzyGD11268 embryonic ventral epidermis fzy3 fzyunspecified embryonic ventral nervous system fzyunspecified female germline stem cell | germline clone fzy1 ganglion mother cell | larval stage, with Scer\GAL41407 fzyGD11268 mitosis & nuclear chromosome fzy3 mitotic cell cycle fzy3 mitotic cell cycle & epidermis & embryo | ventral fzy1 mitotic cell cycle & spindle & epidermis & embryo | ventral fzy1 spindle | embryonic stage fzy6 fzy7 trichogen cell, with Scer\GAL4pnr-MD237 fzyGD11268 wing | posterior compartment, with Scer\GAL4en-e16E fzyScer\UAS.cSa
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of fzy Class Mutagen Stocks Known lesion fzy1 amorphic allele - genetic evidence ethyl methanesulfonate 3 -- fzy3 amorphic allele - genetic evidence ethyl methanesulfonate 1 -- fzyEP1028 P-element activity 1 -- fzy2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- fzy4 hypomorphic allele - genetic evidence 0 -- fzy5 hypomorphic allele - genetic evidence 0 -- fzy6 hypomorphic allele - genetic evidence 0 -- fzy7 hypomorphic allele - genetic evidence 0 -- fzy8 0 -- fzyID X ray 0 -- fzyunspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fzy Class Mutagen Stocks Known lesion fzyGD11268 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes fzyGL00442 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzyHM04081 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzyHMS00964 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzyKK101352 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fzydsRNA.cHa in vitro construct - RNAi 0 Yes fzydsRNA.cMa in vitro construct - RNAi 0 -- fzyScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes fzytDa in vitro construct - genomic fragment 0 Yes fzyUbi-p63E.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7065 (Ryder, 2004.4.26) Df(2L)H60-3 (Ashburner et al., 1999, Dawson et al., 1995, Roth et al., 1995) Df(2L)II30 (Roote, 1996.8) Df(2L)III18 (Ashburner et al., 1999, Roth et al., 1995, Bergmann et al., 1996, Roote, 1996.8) Df(2L)k08106-rv4 (Roote, 2000.6.13) Df(2L)k08106-rv6 (Roote, 1999.7.7, Roote, 2000.6.13) Df(2L)k08106-rv15 (Roote, 1999.7.7, Roote, 2000.6.13) Df(2L)k14608-mr15 (Roote, 2000.6.13) Df(2L)r10 (Ashburner et al., 1990, Dawson et al., 1993) Df(2L)RA5 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)RN2 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1993, Dawson et al., 1995, Sigrist et al., 1995) Df(2L)Scorv16 (Ashburner et al., 1990) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990, Dawson et al., 1995) Df(2L)TE35D-23 (Ashburner et al., 1990)
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A72 (Ashburner et al., 1990) Df(2L)A267 (Ashburner et al., 1990) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)cact-255rv64 (Dawson et al., 1995, Roote, 1996.1.11, Roote, 1996.8) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)k17027rv1 (Roote, 2000.6.13) Df(2L)k17027rv3 (Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp29 (Eberl et al., 1998) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990) Df(2L)Scorv25 (Ashburner et al., 1990) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-34 (Ashburner et al., 1990) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-13 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) Df(2L)TE35D-14 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-22 (Ashburner et al., 1990) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990)
Duplicated in	Dp(2;3)osp3 (Ashburner et al., 1990)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11268} NA P{KK101352} NA P{TRiP.GL00442} NA P{TRiP.HM04081} NA P{TRiP.HMS00964} NA P{UAS-fzy.S} NA characterization construct P{fzytDa} NA P{Ubi-p63E-fzy.GFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}fzyEP1028 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Kiger et al., 2003) cellular process inferred from mutant phenotype (Boutros et al., 2004) cyclin catabolic process inferred from direct assay (Dawson et al., 1995) inferred from mutant phenotype (Swan and Schupbach, 2007) female meiosis I inferred from genetic interaction with cort (Swan and Schupbach, 2007) female meiosis II inferred from mutant phenotype (Swan and Schupbach, 2007) germ-line stem cell maintenance inferred from mutant phenotype (Chen et al., 2009) mitosis inferred from mutant phenotype (Ducat et al., 2008) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) protein catabolic process inferred from mutant phenotype (Raff et al., 2002)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Raff et al., 2002) kinetochore inferred from direct assay (Raff et al., 2002) spindle inferred from direct assay (Raff et al., 2002)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of exit from mitosis traceable author statement (Lee and Orr-Weaver, 2003) regulation of proteolysis traceable author statement (Lee and Orr-Weaver, 2003)
Cellular Component
CV term Evidence References
centrosome traceable author statement (Lee and Orr-Weaver, 2003) cytoplasm traceable author statement (Lee and Orr-Weaver, 2003) kinetochore traceable author statement (Lee and Orr-Weaver, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fzy allele Gene References fzyunspecified pim (Leismann et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60979 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001086 DroID - A comprehensive database of gene and protein interactions. • FBgn0001086 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34968
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14581 Dere\GG25203 Dgri\GH10315 Dmoj\GI17076 Dper\GL16343 Dpse\GA18074 Dsec\GM18667 Dsim\GD24052 Dvir\GJ10640 Dwil\GK23987 Dyak\GE21464
Curated drosophilid orthologs	Dpse\GA18074
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014025-PA Aedes aegypti (mosquito) AGAP009338-PA Anopheles gambiae (mosquito) XP_624567.2 Apis mellifera (honey bee) XP_001946920.1 Acyrthosiphon pisum (pea aphid) At4g33260.1 Arabidopsis thaliana (wall cress) At4g33270.1 Arabidopsis thaliana (wall cress) 2171 Batrachochytrium dendrobatidis (chytrid fungus) 124768 Branchiostoma floridae (lancelet) XP_001893850.1 Brugia malayi (roundworm nematode) ENSBTAP00000012945 Bos taurus (bovine) CN04610 Caenorhabditis brenneri (small nematode) ENSCAFP00000007875 Canis familiaris (dog) ENSCINP00000012774 Ciona intestinalis (sea squirt) JA10428 Caenorhabditis japonica (nematode) CMA138C Cyanidioschyzon merolae (red alga) cn07097 Cryptococcus neoformans (yeast-like fungus) CPIJ014702 Culex pipens (mosquito) ENSCPOP00000005494 Cavia porcellus (guinea pig) 130713 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000009432 Ciona savignyi (sedentary tunicate) 152549 Capitella spl (polychaete worm) DDB0237885 Dictyostelium discoideum (amoeba) 308214 Daphnia pulex (daphnia) ENSDARP00000006680 Danio rerio (zebra fish) ENSECAP00000017512 Equus caballus (horse) ENSGACP00000018020 Gymnopilus aculeatus (mushroom) ENSGALP00000016189 Gallus gallus (chicken) ENSP00000308450 Homo sapiens (human) 193514 Lottia gigantea (owl limpet) 10098 Monocosta brevicollis (choanoflagellate) ENSMODP00000014173 Monodelphis domestica (gray opossum) ENSMMUP00000004215 Macaca mulatta (rhesus monkey) ENSMUSP00000006565 Mus musculus (house mouse) 192701 Nematostella vectensis (starlet anemone) XP_001606012.1 Nasonia vitripennis (wasp) ENSOANP00000013047 Ornithorynchus anatinus (platypus) ENSORLP00000020595 Oryzias latipes (japanese killifish) LOC_Os02g47180.1 Oryza sativa (asian rice) 10799 Ostreococcus tauri (green alga) PF10_0261 Plasmodium falciparum (protozoal parasite) PHUM001792-PA Pediculus humanus (human body louse) 130843 Physcomitrella patens (moss) ENSPPYP00000001678 Pongo pygmaeus (orangutan) 77091 Phytophthora ramorum (sudden oak death pathogen) 129188 Phytophthora sojae (root rot pathogen) 571123 Populus trichocarpa (black cottonwood) 738273 Populus trichocarpa (black cottonwood) ENSPTRP00000001089 Pan troglodytes (chimpanzee) ENSRNOP00000037772 Rattus norvegicus (norway rat) 5055010 Sorghum bicolor (sorghum) Smp_004060 Schistosoma mansoni (trematode parasite) SPAC821.08c Schizosaccharomyces pombe (fission yeast) XP_001175927.1 Strongylocentrotus purpuratus (purple sea urchin) 58017 Trichoplax adhaerens (metazoa) XP_969612.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018324 Tetraodon nigroviridis (green spotted pufferfish) 31062 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019538 Takifugu rubripes (pufferfish Takifugu) 21.m00369 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008405 Xenopus tropicalis (frog) YALI0C03377g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15992 NV11981 LH11647 FBgn0238721 FBgn0225949 FBgn0197918 FBgn0195410 FBgn0173573 FBgn0250544 JGI_V11_308214 FBgn0243739 FBgn0078082 FBgn0164565 FBgn0153947 FBgn0139821 FBgn0117796 FBgn0117327 FBgn0091608 CPIJ014702 CPIJ014700 BGIBMGA011028 ACYPI008457 GB10871 AGAP009338 AAEL014025 PHUM195130 GLEAN_01383
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	31768 y1 v1; P{TRiP.HM04081}attP2 2492 fzy1 cn1 bw1 sp1/CyO 34001 y1 sc* v1; P{TRiP.HMS00964}attP2 35805 y1 sc* v1; P{TRiP.GL00442}attP40 26661 Su(H)IB115 fzy1 cn1 bw1 sp1/CyO 25143 b1 fzy3 pr1 cn1 wxwxt bw1/CyO
Kyoto	122033 w1118; P{EP}fzyEP1028 107364 fzy1 cn1 bw1 sp1/CyO
VDRC	v105114 P{KK101352}VIE-260B v40500 w1118; P{GD11268}v40500 v44834 w1118; P{GD11268}v44834
Genomic Clones ( 1 )
	BACR01N08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 133 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE39287
Other clones	FI02843
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03715 AT05305 AT23782 AT30869 GH02903 GM02166 GM10572 LD08545 LD08754 LD11224 LD12520 LD13309 LD14034 LD18042 LD18190 LD22440 LD22633 LD22763 LD23923 LD24209 LD24520 LD24735 LD26949 LD31127 LD32995 LD33694 LD34516 LD38169 LD38520 LD39303 LD41402 LD41786 LD42559 LD43828 LD46133 LD46217 RE03286 RE03916 RE04209 RE04417 RE06234 RE06557 RE06602 RE10385 RE12339 RE20580 RE22681 RE24728 RE27707 RE28541 RE29108 RE29524 RE29723 RE32303 RE36621 RE44344 RE44364 RE45240 RE50321 RE51703 RE54372 RE54968 RE65355 RE65903 RE66452 SD09437 SD09641 SD13940 SD20814 SD24320 SD25528
Other clones	13088 14845 44196 80706 106064 Dmel_dig_014764_0659_2411 EK114338 EK117510 EK159458 EK213833 ESG012d.E21_C07 LD30572 RP003011356 RP003025013 RP003042982 RP003049082 RP003084424 RP003087096 RP003097798 RP003106156 RP003126963 RP003144322 RP003161639 RP003168546 RP003171328 RP003239599 RP003241386 RP003248631 RP003257097 RP003261667 RP003273405 RP003305457 RP003308682 RP003310918 RP003311434 RP003313407 RP003329320 RP003339588 RP003343164 RP003354658 RP003407144 RP003430896 RP003445096 RP003463244 RP003472318 RP003472556 RP003474610 RP003486019 RP003512788 RP003536501 RP003567052 RP003583023 RP003594334 RP003596486 RP003609459 RP003642979 RP003669142 UT01535 UUGC0256 UUGC0259
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001086 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34968
Antibody Information
	monoclonal (Dawson et al., 1995)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: fzy CG4274 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Eggs derived from mutant females almost invariably arrest in anaphase of meiosis II. (Swan and Schupbach, 2007) cort and fzy are required for anaphase progression in both female meiotic divisions, performing partially redundant roles in meiosis I and non-redundant roles in meiosis II. (Swan and Schupbach, 2007) SL2 cells treated with dsRNA against fzy show a clear increase in the mitotic index compared to control cells. (Muller et al., 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell morphology is aberrant and there is an increased frequency of microtubule-based mitotic spindles, indicative of a failure in mitosis. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) fzy is required for timely disengagement of mother and daughter centrioles in embryos. (Vidwans et al., 1999) The metaphase arrest seen in fzy mutants persists in the absence of pim or thr function. (Philp and Glover, 1997) fzy has been cloned and sequenced, and its expression pattern has been analysed. (Dawson et al., 1995) Mutations in fzy result in metaphase arrest, neither CycA, CycB or CycB3 are degraded in this arrest. Comparison of the fzy mutant phenotype with the phenotype resulting from expression of N-terminal truncated CycA, CycB or CycB3 suggests that fzy is not only required for mitotic cyclin degradation because fzy mutations, but not truncated cyclins, block chromosome separation. Inactivation of a temperature sensitive cdc2 in fzy metaphase arrest causes a reversion to interphase morphology. This reversion is not accompanied by completion of mitosis so there is no increase in anaphase cells or change in cell number or size. (Sigrist et al., 1995) The fizzy gene function is required maternally and zygotically for dividing cells to exit metaphase and complete mitosis. Zygotic fzy is required for normal differentiation of the ventral neurogenic ectoderm. Double mutant analysis shows that stg is epistatic to fzy. (Dawson et al., 1993) 3 additional alleles are discussed but are not named. (Ashburner et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058153 RefSeq (Proteins) • NP_477501 DDBJ / EMBL / GenBank • AA141574 AA264915 AA390445 AA392353 AA438434 AA438914 AA439457 AA538619 AA695117 AA803324 AA816831 AA817243 AA817370 AA820125 AA820352 AA820465 AA820679 AA820827 AA942626 AA950658 AA950942 AA978824 AA979308 AA990693 AAA83150 AAF53523 AAQ23567 AC092398 AE003415 AI064676 AQ025016 BI242071 BT010249 U22419 Entrez Gene - A searchable database of RefSeq genes. • 34968 UniProtKB/TrEMBL • Q6NR32 Q24044
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60979 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001086 DroID - A comprehensive database of gene and protein interactions. • FBgn0001086 DRSC - Results from RNAi screens. • FBgn0001086 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001086 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • LD44795;CG4274-RA;Stencil:U:4573297:4567654:GENSCAN FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001086 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34968 InParanoid A subset of ortholog calls from InParanoid. • AAEL014025-PA Aedes aegypti (mosquito) AGAP009338-PA Anopheles gambiae (mosquito) XP_624567.2 Apis mellifera (honey bee) XP_001946920.1 Acyrthosiphon pisum (pea aphid) At4g33260.1 Arabidopsis thaliana (wall cress) At4g33270.1 Arabidopsis thaliana (wall cress) 2171 Batrachochytrium dendrobatidis (chytrid fungus) 124768 Branchiostoma floridae (lancelet) XP_001893850.1 Brugia malayi (roundworm nematode) ENSBTAP00000012945 Bos taurus (bovine) CN04610 Caenorhabditis brenneri (small nematode) ENSCAFP00000007875 Canis familiaris (dog) ENSCINP00000012774 Ciona intestinalis (sea squirt) JA10428 Caenorhabditis japonica (nematode) CMA138C Cyanidioschyzon merolae (red alga) cn07097 Cryptococcus neoformans (yeast-like fungus) CPIJ014702 Culex pipens (mosquito) ENSCPOP00000005494 Cavia porcellus (guinea pig) 130713 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000009432 Ciona savignyi (sedentary tunicate) 152549 Capitella spl (polychaete worm) DDB0237885 Dictyostelium discoideum (amoeba) 308214 Daphnia pulex (daphnia) ENSDARP00000006680 Danio rerio (zebra fish) ENSECAP00000017512 Equus caballus (horse) ENSGACP00000018020 Gymnopilus aculeatus (mushroom) ENSGALP00000016189 Gallus gallus (chicken) ENSP00000308450 Homo sapiens (human) 193514 Lottia gigantea (owl limpet) 10098 Monocosta brevicollis (choanoflagellate) ENSMODP00000014173 Monodelphis domestica (gray opossum) ENSMMUP00000004215 Macaca mulatta (rhesus monkey) ENSMUSP00000006565 Mus musculus (house mouse) 192701 Nematostella vectensis (starlet anemone) XP_001606012.1 Nasonia vitripennis (wasp) ENSOANP00000013047 Ornithorynchus anatinus (platypus) ENSORLP00000020595 Oryzias latipes (japanese killifish) LOC_Os02g47180.1 Oryza sativa (asian rice) 10799 Ostreococcus tauri (green alga) PF10_0261 Plasmodium falciparum (protozoal parasite) PHUM001792-PA Pediculus humanus (human body louse) 130843 Physcomitrella patens (moss) ENSPPYP00000001678 Pongo pygmaeus (orangutan) 77091 Phytophthora ramorum (sudden oak death pathogen) 129188 Phytophthora sojae (root rot pathogen) 571123 Populus trichocarpa (black cottonwood) 738273 Populus trichocarpa (black cottonwood) ENSPTRP00000001089 Pan troglodytes (chimpanzee) ENSRNOP00000037772 Rattus norvegicus (norway rat) 5055010 Sorghum bicolor (sorghum) Smp_004060 Schistosoma mansoni (trematode parasite) SPAC821.08c Schizosaccharomyces pombe (fission yeast) XP_001175927.1 Strongylocentrotus purpuratus (purple sea urchin) 58017 Trichoplax adhaerens (metazoa) XP_969612.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018324 Tetraodon nigroviridis (green spotted pufferfish) 31062 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019538 Takifugu rubripes (pufferfish Takifugu) 21.m00369 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008405 Xenopus tropicalis (frog) YALI0C03377g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/fizzy1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34968 modMine - Data generated by the modENCODE project. • FBgn0001086 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15992 NV11981 LH11647 FBgn0238721 FBgn0225949 FBgn0197918 FBgn0195410 FBgn0173573 FBgn0250544 JGI_V11_308214 FBgn0243739 FBgn0078082 FBgn0164565 FBgn0153947 FBgn0139821 FBgn0117796 FBgn0117327 FBgn0091608 CPIJ014702 CPIJ014700 BGIBMGA011028 ACYPI008457 GB10871 AGAP009338 AAEL014025 PHUM195130 GLEAN_01383
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	BG:DS02740.14 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) cdc20 (Muller et al., 2006, Slack et al., 2007, Chen et al., 2009, Buttitta et al., 2010) CDC20 (Swan et al., 2005, Peters, 1999, Papoulas et al., 2010) Cdc20 (Raff et al., 2002, Karess, 2005, Swan and Schupbach, 2007, Chia et al., 2008, Somma et al., 2008, Tanaka-Matakatsu et al., 2007, Narbonne-Reveau et al., 2008, Oliveira et al., 2010, Li et al., 2010) Cdc20/Fizzy (van Roessel et al., 2004) cdc20/fizzy (Li and White, 2003) Cdc20/Fzy (Swan and Schüpbach, 2007) Cdc20fizzy (Marshall, 2001) Cdc20Fzy (Grosskortenhaus and Sprenger, 2002) CG4274 (Ducat et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) dCDC20 (Chen et al., 2009) dFZY (Dobie et al., 1999) Fizzy (Lehner, 2003) fzy (Liu et al., 2005, Stroschein-Stevenson et al., 2006, Hueber et al., 2007, Savoian and Rieder, 2002, Swan and Schupbach, 2007, Ma et al., 2006, Pesin and Orr-Weaver, 2007, Somma et al., 2008, Slack et al., 2007, Dworkin et al., 2009, Chen et al., 2009, Scaria et al., 2008, Tanaka-Matakatsu et al., 2007, Magalhaes et al., 2007, Zhang et al., 2011, Neumüller et al., 2011) Fzy (Li et al., 2007, Huang and Raff, 2002, Acquaviva and Pines, 2006, Narbonne-Reveau et al., 2008, Pandey et al., 2007, Khan et al., 2009, Buttitta et al., 2010) FZY (Papoulas et al., 2010) Fzy/Cdc20 (Garcia et al., 2007)
Name Synonym	Cdc20 (Pines, 2006) fizzy (Pines, 2006, Liu et al., 2005, Siegrist and Doe, 2005, Savoian and Rieder, 2002, Pesin and Orr-Weaver, 2007, Somma et al., 2008, Scaria et al., 2008, Chen et al., 2009) Fizzy (Acquaviva and Pines, 2006, Ducat et al., 2008)
Secondary FlyBase IDs
References ( 130 )
Generate a list of	All references relating to this gene ( 130 )
List References by type	Research paper  ( 68 ) Supplementary material  ( 8 ) Review  ( 20 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 2 )
Recent research papers ( 7 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Buttitta et al., 2010, J. Cell Biol. 189(6): 981--996 A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. [FBrf0211029] Li et al., 2010, Mol. Cell. Biol. 30(13): 3384--3395 Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster. [FBrf0210988] Oliveira et al., 2010, Nat. Cell Biol. 12(2): 185--192 Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. [FBrf0209876] Papoulas et al., 2010, Development 137(24): 4201--4209 dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. [FBrf0212321] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...