Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Gene model reviewed during 5.54
4.0, 3.8 (northern blot)
None of the polypeptides share 100% sequence identity.
1034 (aa); 115 (kD predicted)
Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large chains (delta and beta3), a medium chain (mu3) and a small chain (sigma3).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\g using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\g in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Shows genomic imprinting on Dp(1;f)LJ9. These variegating phenotypes persist for one generation only, i.e. is reset by passage through the germ line. The imprint is a response to the physiological sex of the parent, and does not depend on the particular allele of g opposite Dp(1;f)LJ9. Factors that affect position effect variegation influence the somatic expression but not the establishment of the imprinting.
The eye pigmentation defect of g mutants suggests the protein is required for proper biogenesis of eye pigment granules.
Eye color brownish, darkening with age; both pteridine and ommochrome pigments variably reduced in different alleles, giving rise to such descriptions as deep purplish ruby, pinkish, brownish, yellowish ruby, orange, etc.
Lesions in g reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules: g is required for normal pigmentation of all four tissues.
Pteridines (neodrosopterin, drosopterin, isodrosopterin, aurodrosopterin, 6-acetyl-dihydrohomopterin, sepiapterin, dihydrobiopterin, biopterin, pterin and isoxanthopterin) have been quantified in single and double mutants.
It is likely that this gene is required for the normal transport of eye-pigment precursors.
Pigmentation of Malpighian tubules also reduced.
Bridges, 19th Feb. 1915.