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Gene Dmel\bnb

General Information
Symbol	Dmel\bnb	Species	D. melanogaster
Name	bangles and beads	Annotation symbol	CG7088
Feature type	protein_coding_gene	FlyBase ID	FBgn0001090
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	17D6-17D6	Sequence location	X:18,688,553..18,691,712 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bangles and beads is referred to in FlyBase by the symbol Dmel\bnb (CG7088, FBgn0001090). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: multicellular organismal development; gliogenesis. 4 alleles are reported. The phenotypes of these alleles are annotated with: embryonic epidermis; presumptive embryonic/larval central nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632734_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of bnb. Gene sequence location is X:18688553..18691712.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17D6-17D6   Limits computationally determined from genome sequence between P{EP}Pk17EEP438 and P{EP}EP1597
Experimentally Determined Cytological Location
Cytogenetic map Notes References 17E3-17E9   (determined by in situ hybridisation)   (Ng et al., 1989)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bnb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bnb-RA FBtr0074658  NM_167633   2095   442 bnb-RB FBtr0074656  NM_167634   2124   442 bnb-RC FBtr0074657  NM_078682   1939   442 bnb-RD FBtr0074659  NM_167635   1820   442
Additional Transcript Data & Comments
Reported size (kB)	2.4, 2.0 (northern blot) (Ng et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bnb-PA   FBpp0074429   45.8   442   4.30     NP_728201   AAN09476 bnb-PB   FBpp0074427   45.8   442   4.30     NP_728202   AAF48888 bnb-PC   FBpp0074428   45.8   442   4.30     NP_523406   AAN09477 bnb-PD   FBpp0074430   45.8   442   4.30     NP_728203   AAN09478
Additional Polypeptide Data & Comments
Reported size (kDa)	441 (aa) (Ng et al., 1989)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142231   AA263413   AA433285   AA440369   AA536290   AA567701   AA697521   AA697751   AA697925   AA698433   AA698453   AA698556   AA801513   AA801515   AA941323   AA950434   AA950524   AE014298 AAF48888   AE014298 AAN09476   AE014298 AAN09477   AE014298 AAN09478   AI107023   AI107152   AI108645   AI108723   AI109141   AI109658   AI113388   AI134576   AI134939   AI135802   AI237985   AI238815   AI258416   AI292810   AI292983   AI296819   AI387255   AI388238   AI389706   AI389951   AI402517   AI403344   AI404996   AI405146   AI456759   AI457065   AI516464   AI516983   AI517110   AI519650   AI543884   AW940448   AY060682 AAL28230   BG638596   BI164212   BI164224   BI165197   BI165722   BI167045   BI169744   BI169800   BI170814   BI171715   BI172507   BI212292   BI213900   BI214220   BI215821   BI232472   BI234389   BI237107   BI237926   BI239760   BI240743   BI243475   BI243666   BI357105   BI357106   BI362053   BI363687   BI364539   BI365990   BI366880   BI367495   BI370859   BI371046   BI373421   BI373452   BI373632   BI374235   BI374945   BI375575   BI375753   BI375791   BI483379   BI483537   BI483888   BI483902   BI484304   BI565653   BI568712   BI574295   BI574642   BI575151   BI578693   BI578822   BI579974   BI580193   BI581199   BI581226   BI584630   BI585466   BI586405   BI604243   BI604394   BI606889   BI608329   BI610174   BI614138   BI616818   BI616867   BI619182   BI619356   BI620810   BI622974   BI629866   BI629945   BI629976   BP548985   BP548986   BP550682   BP550683   BP554922   BQ103072   BQ103291   CK604581   CK604842   CK604843   CK604916   CK604917   CK604966   CK604967   CK605008   CK605009   CK658468   CK658756   CK660540   CK660884   CK662058   CK662184   CK662201   CO185740   CO187634   CO190365   CO191020   CO195911   CO196035   CO263188   CO264412   CO265106   CO274914   CO281367   CO282284   CO282304   CO286542   CO287113   CO287340   CO287881   CO295280   CO296201   CO297562   CO299378   CO305691   CO307774   CO309317   CO311846   CO312360   CO312892   CO317087   CO318782   CO322351   CO322742   CO323492   CO326325   CO330855   CO337639   EC056669   EC057524   EC059256   EC061571   EC064354   EC064955   EC065086   EC071457   EC075587   EC088132   EC090586   EC194583   EC196099   EC198811   EC200619   EC201821   EC206957   EC207046   EC207390   EC210908   EC216107   EC218118   EC218443   EC220261   EC220874   EC224710   EC225687   EC230258   EC234140   EC234979   EC235021   EC235281   EC236747   EC237061   EC239483   EC241984   EC246555   EC247531   EC249295   EC249470   EC254390   EC264315   EL870106   EL873648   EL873649   EL885634   EL885635   EL885744   EL885745   EL885875   EL885876   GH758679   GH798048   GH819466   GH835174   GH861459   GH863196   GH870260   GH886127   GH925570   GH934611   GH944012   GH946007   GH957542   GH957580   GH965821   GH967590   GH972181   GH982483   X63828 CAA45323
UniProtKB/Swiss-Prot	P29746
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Ng et al., 1989) subesophageal ganglion   (Ng et al., 1989) epidermis   (Ng et al., 1989) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   amnioserosa   (Ng et al., 1989) glial cell   (Ng et al., 1989) mesectoderm   (Ng et al., 1989) supraesophageal ganglion   (Ng et al., 1989) embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi hindgut anlage in statu nascendi   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium inclusive hindgut primordium   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) apoptotic amnioserosa   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012)
Additional Descriptive Data
	bnb transcripts are present throughout development with peaks at 4-13hr of embryogenesis and 0-24hr of pupation. Prior to dorsal closure, bnb is expressed in a number of tissues and is most prominant in the mesectoderm and in the presumptive ectoderm. Expression is highest in the dorsal most cells of the epidermis and, along the anterior posterior axis, it is most prominent just anterior to the segment borders. After dorsal closure, expression is restricted to the nervous system and occurs in a segmentally repeating pattern along the periphery of the nervous system. bnb-expressing cells in the CNS include some glial cells. (Ng et al., 1989)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    692.5 Larval Midgut    11.6 Larval Hindgut    1307.7 Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head    1342.1 Adult Eye    2019.15 Adult Brain    1604.7 Adult Thoracic-Abdominal Ganglion    1882.5 Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut    779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (692.5) Larval Midgut    11.6 Larval Hindgut  (1307.7) Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head  (1342.1) Adult Eye  (2019.15) Adult Brain  (1604.7) Adult Thoracic-Abdominal Ganglion  (1882.5) Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut  (779) Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    692.5 Larval Midgut    11.6 Larval Hindgut  (1307.7) Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head  (1342.1) Adult Eye  (2019.15) Adult Brain  (1604.7) Adult Thoracic-Abdominal Ganglion  (1882.5) Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut    779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    692.5 Larval Midgut    11.6 Larval Hindgut    1307.7 Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head    1342.1 Adult Eye    2019.15 Adult Brain    1604.7 Adult Thoracic-Abdominal Ganglion    1882.5 Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut    779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    692.5 Larval Midgut    11.6 Larval Hindgut    1307.7 Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head    1342.1 Adult Eye    2019.15 Adult Brain    1604.7 Adult Thoracic-Abdominal Ganglion    1882.5 Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut    779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  692.5 Larval Midgut    11.6 Larval Hindgut  (1307.7) Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head  (1342.1) Adult Eye  (2019.15) Adult Brain  (1604.7) Adult Thoracic-Abdominal Ganglion  (1882.5) Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut  779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    692.5 Larval Midgut    11.6 Larval Hindgut  1307.7 Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head  1342.1 Adult Eye  (2019.15) Adult Brain  1604.7 Adult Thoracic-Abdominal Ganglion  (1882.5) Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut    779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    692.5 Larval Midgut    11.6 Larval Hindgut    1307.7 Larval Malpighian Tubules    10.3 Larval Fat Body    37.6 Larval Salivary Gland    8.6 Larval Trachea    120.45 Larval Carcass    199 Adult Head    1342.1 Adult Eye    2019.15 Adult Brain    1604.7 Adult Thoracic-Abdominal Ganglion    1882.5 Adult Crop    27.4 Adult Midgut    1.7 Adult Hindgut    779 Adult Malpighian Tubules    4.5 Adult Fat Body    23.4 Adult Salivary Gland    12.8 Adult Heart    26.025 Adult VirginFemale Spermatheca    16.4 Adult InseminatedFemale Spermatheca    24 Adult Ovary    33.7 Adult Testis    146 Adult Male Accessory Gland    16.8 Adult Carcass    170.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1342.1   NA  Eye    2019.15   NA  Brain    1604.7   692.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1882.5   NA  Crop    27.4   no informative data  Midgut    1.7   1307.7  Hindgut    779   no informative data  Malpighian Tubules    4.5   37.6  Fat Body    no informative data   8.6  Salivary Gland    no informative data   NA  Heart    26.025   120.45  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    24   NA  Ovary    33.7   NA  Testis    146   NA  Male Accessory Gland    no informative data   199  Carcass    170.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    514 central nervous system, larvae L3    346 central nervous system, pupae P8    724 head, virgin 1-day female    515 head, virgin 4-day female    396 head, virgin 20-day female    203 head, mated 1-day female    504 head, mated 4-day female    264 head, mated 20-day female    245 head, mated 1-day male    725 head, mated 4-day male    515 head, mated 20-day male    436 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    12 fat body, white prepupae    65 fat body, pupae P8    421 carcass, larvae L3 wandering    248 carcass, 1-day adult    76 carcass, 4-day adult    56 carcass, 20-day adult    81 ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male    33 accessory gland, mated 4-day male    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (514) central nervous system, larvae L3  (346) central nervous system, pupae P8  (724) head, virgin 1-day female  (515) head, virgin 4-day female  (396) head, virgin 20-day female  (203) head, mated 1-day female  (504) head, mated 4-day female  (264) head, mated 20-day female  (245) head, mated 1-day male  (725) head, mated 4-day male  (515) head, mated 20-day male  (436) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult  (29) fat body, larvae L3 wandering    12 fat body, white prepupae  (65) fat body, pupae P8  (421) carcass, larvae L3 wandering  (248) carcass, 1-day adult  (76) carcass, 4-day adult  (56) carcass, 20-day adult  (81) ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male  (33) accessory gland, mated 4-day male  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (514) central nervous system, larvae L3  (346) central nervous system, pupae P8  (724) head, virgin 1-day female  (515) head, virgin 4-day female  (396) head, virgin 20-day female  (203) head, mated 1-day female  (504) head, mated 4-day female  (264) head, mated 20-day female  (245) head, mated 1-day male  (725) head, mated 4-day male  (515) head, mated 20-day male  (436) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    12 fat body, white prepupae    65 fat body, pupae P8  (421) carcass, larvae L3 wandering  (248) carcass, 1-day adult    76 carcass, 4-day adult    56 carcass, 20-day adult    81 ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male    33 accessory gland, mated 4-day male    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    514 central nervous system, larvae L3    346 central nervous system, pupae P8    724 head, virgin 1-day female    515 head, virgin 4-day female    396 head, virgin 20-day female    203 head, mated 1-day female    504 head, mated 4-day female    264 head, mated 20-day female    245 head, mated 1-day male    725 head, mated 4-day male    515 head, mated 20-day male    436 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    12 fat body, white prepupae    65 fat body, pupae P8    421 carcass, larvae L3 wandering    248 carcass, 1-day adult    76 carcass, 4-day adult    56 carcass, 20-day adult    81 ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male    33 accessory gland, mated 4-day male    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    514 central nervous system, larvae L3    346 central nervous system, pupae P8    724 head, virgin 1-day female    515 head, virgin 4-day female    396 head, virgin 20-day female    203 head, mated 1-day female    504 head, mated 4-day female    264 head, mated 20-day female    245 head, mated 1-day male    725 head, mated 4-day male    515 head, mated 20-day male    436 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    12 fat body, white prepupae    65 fat body, pupae P8    421 carcass, larvae L3 wandering    248 carcass, 1-day adult    76 carcass, 4-day adult    56 carcass, 20-day adult    81 ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male    33 accessory gland, mated 4-day male    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (514) central nervous system, larvae L3  (346) central nervous system, pupae P8  (724) head, virgin 1-day female  (515) head, virgin 4-day female  (396) head, virgin 20-day female  (203) head, mated 1-day female  (504) head, mated 4-day female  (264) head, mated 20-day female  (245) head, mated 1-day male  (725) head, mated 4-day male  (515) head, mated 20-day male  (436) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult  29 fat body, larvae L3 wandering    12 fat body, white prepupae  (65) fat body, pupae P8  (421) carcass, larvae L3 wandering  (248) carcass, 1-day adult  (76) carcass, 4-day adult  (56) carcass, 20-day adult  (81) ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male  (33) accessory gland, mated 4-day male  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (514) central nervous system, larvae L3  (346) central nervous system, pupae P8  (724) head, virgin 1-day female  (515) head, virgin 4-day female  (396) head, virgin 20-day female  (203) head, mated 1-day female  (504) head, mated 4-day female  (264) head, mated 20-day female  (245) head, mated 1-day male  (725) head, mated 4-day male  (515) head, mated 20-day male  (436) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    12 fat body, white prepupae    65 fat body, pupae P8  (421) carcass, larvae L3 wandering  (248) carcass, 1-day adult    76 carcass, 4-day adult    56 carcass, 20-day adult    81 ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male    33 accessory gland, mated 4-day male    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    514 central nervous system, larvae L3    346 central nervous system, pupae P8    724 head, virgin 1-day female    515 head, virgin 4-day female    396 head, virgin 20-day female    203 head, mated 1-day female    504 head, mated 4-day female    264 head, mated 20-day female    245 head, mated 1-day male    725 head, mated 4-day male    515 head, mated 20-day male    436 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    11 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    12 fat body, white prepupae    65 fat body, pupae P8    421 carcass, larvae L3 wandering    248 carcass, 1-day adult    76 carcass, 4-day adult    56 carcass, 20-day adult    81 ovary, virgin 4-day female    1 ovary, mated 4-day female    6 testis, mated 4-day male    33 accessory gland, mated 4-day male    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    803 embryo 04-06hr    942 embryo 06-08hr    560 embryo 08-10hr    493 embryo 10-12hr    401 embryo 12-14hr    437 embryo 14-16hr    226 embryo 16-18hr    103 embryo 18-20hr    163 embryo 20-22hr    102 embryo 22-24hr    97 larva L1    70 larva L2    101 larva L3 12hr old    70 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    69 white prepupae new    84 white prepupae 12hr    123 white prepupae 24hr    5782 pupae 2d postWPP    285 pupae 3d postWPP    85 pupae 4d postWPP    93 adult male 01day    77 adult male 05day    60 adult male 30day    44 adult female 01day    49 adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40) embryo 02-04hr  (803) embryo 04-06hr  (942) embryo 06-08hr  (560) embryo 08-10hr  (493) embryo 10-12hr  (401) embryo 12-14hr  (437) embryo 14-16hr  (226) embryo 16-18hr  (103) embryo 18-20hr  (163) embryo 20-22hr  (102) embryo 22-24hr  (97) larva L1  (70) larva L2  (101) larva L3 12hr old  (70) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9  (69) white prepupae new  (84) white prepupae 12hr  (123) white prepupae 24hr  (5782) pupae 2d postWPP  (285) pupae 3d postWPP  (85) pupae 4d postWPP  (93) adult male 01day  (77) adult male 05day  (60) adult male 30day  (44) adult female 01day  (49) adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr  (803) embryo 04-06hr  (942) embryo 06-08hr  (560) embryo 08-10hr  (493) embryo 10-12hr  (401) embryo 12-14hr  (437) embryo 14-16hr  (226) embryo 16-18hr  103 embryo 18-20hr  (163) embryo 20-22hr  102 embryo 22-24hr    97 larva L1    70 larva L2  101 larva L3 12hr old    70 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    69 white prepupae new    84 white prepupae 12hr  (123) white prepupae 24hr  (5782) pupae 2d postWPP  (285) pupae 3d postWPP    85 pupae 4d postWPP    93 adult male 01day    77 adult male 05day    60 adult male 30day    44 adult female 01day    49 adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    803 embryo 04-06hr    942 embryo 06-08hr    560 embryo 08-10hr    493 embryo 10-12hr    401 embryo 12-14hr    437 embryo 14-16hr    226 embryo 16-18hr    103 embryo 18-20hr    163 embryo 20-22hr    102 embryo 22-24hr    97 larva L1    70 larva L2    101 larva L3 12hr old    70 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    69 white prepupae new    84 white prepupae 12hr    123 white prepupae 24hr    5782 pupae 2d postWPP    285 pupae 3d postWPP    85 pupae 4d postWPP    93 adult male 01day    77 adult male 05day    60 adult male 30day    44 adult female 01day    49 adult female 05day    16 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    803 embryo 04-06hr    942 embryo 06-08hr    560 embryo 08-10hr    493 embryo 10-12hr    401 embryo 12-14hr    437 embryo 14-16hr    226 embryo 16-18hr    103 embryo 18-20hr    163 embryo 20-22hr    102 embryo 22-24hr    97 larva L1    70 larva L2    101 larva L3 12hr old    70 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    69 white prepupae new    84 white prepupae 12hr    123 white prepupae 24hr    5782 pupae 2d postWPP    285 pupae 3d postWPP    85 pupae 4d postWPP    93 adult male 01day    77 adult male 05day    60 adult male 30day    44 adult female 01day    49 adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40) embryo 02-04hr  (803) embryo 04-06hr  (942) embryo 06-08hr  (560) embryo 08-10hr  (493) embryo 10-12hr  (401) embryo 12-14hr  (437) embryo 14-16hr  (226) embryo 16-18hr  (103) embryo 18-20hr  (163) embryo 20-22hr  (102) embryo 22-24hr  (97) larva L1  (70) larva L2  (101) larva L3 12hr old  (70) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9  (69) white prepupae new  (84) white prepupae 12hr  (123) white prepupae 24hr  (5782) pupae 2d postWPP  (285) pupae 3d postWPP  (85) pupae 4d postWPP  (93) adult male 01day  (77) adult male 05day  (60) adult male 30day  (44) adult female 01day  (49) adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr  (803) embryo 04-06hr  (942) embryo 06-08hr  (560) embryo 08-10hr  (493) embryo 10-12hr  (401) embryo 12-14hr  (437) embryo 14-16hr  (226) embryo 16-18hr  103 embryo 18-20hr  (163) embryo 20-22hr  102 embryo 22-24hr    97 larva L1    70 larva L2  101 larva L3 12hr old    70 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    69 white prepupae new    84 white prepupae 12hr  123 white prepupae 24hr  (5782) pupae 2d postWPP  (285) pupae 3d postWPP    85 pupae 4d postWPP    93 adult male 01day    77 adult male 05day    60 adult male 30day    44 adult female 01day    49 adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    803 embryo 04-06hr    942 embryo 06-08hr    560 embryo 08-10hr    493 embryo 10-12hr    401 embryo 12-14hr    437 embryo 14-16hr    226 embryo 16-18hr    103 embryo 18-20hr    163 embryo 20-22hr    102 embryo 22-24hr    97 larva L1    70 larva L2    101 larva L3 12hr old    70 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    69 white prepupae new    84 white prepupae 12hr    123 white prepupae 24hr    5782 pupae 2d postWPP    285 pupae 3d postWPP    85 pupae 4d postWPP    93 adult male 01day    77 adult male 05day    60 adult male 30day    44 adult female 01day    49 adult female 05day    16 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC    148 ovary OSS    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC  (148) ovary OSS  (101) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC  (148) ovary OSS  101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC    148 ovary OSS    101 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC    148 ovary OSS    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC  (148) ovary OSS  (101) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC  (148) ovary OSS  101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    5 ovary OSC    148 ovary OSS    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    154 cold shock, 4-day adult    151 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    93 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    130 Zinc 4.5 mM 48 hrs, 4-day adult    89 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (154) cold shock, 4-day adult  (151) heat shock, 4-day adult  (34) Cadmium 50 mM 6 hrs, larvae L3  (42) Cadmium 50 mM 12 hrs, larvae L3  (44) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3  (93) Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3  (130) Zinc 4.5 mM 48 hrs, 4-day adult  (89) Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3  (27) Ethanol 10% 3 hrs, larvae L3  (41) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (53) Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult  (60) Paraquat 10 mM 48 hrs, 4-day adult  (48) Rotenone 2 μg 12 hrs, larvae L3  (28) Rotenone 8 μg 12 hrs, larvae L3  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (154) cold shock, 4-day adult  (151) heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    93 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3  (130) Zinc 4.5 mM 48 hrs, 4-day adult    89 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    154 cold shock, 4-day adult    151 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    93 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    130 Zinc 4.5 mM 48 hrs, 4-day adult    89 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    154 cold shock, 4-day adult    151 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    93 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    130 Zinc 4.5 mM 48 hrs, 4-day adult    89 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (154) cold shock, 4-day adult  (151) heat shock, 4-day adult  (34) Cadmium 50 mM 6 hrs, larvae L3  (42) Cadmium 50 mM 12 hrs, larvae L3  (44) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3  (93) Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3  (130) Zinc 4.5 mM 48 hrs, 4-day adult  (89) Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3  27 Ethanol 10% 3 hrs, larvae L3  (41) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (53) Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult  (60) Paraquat 10 mM 48 hrs, 4-day adult  (48) Rotenone 2 μg 12 hrs, larvae L3  28 Rotenone 8 μg 12 hrs, larvae L3  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (154) cold shock, 4-day adult  (151) heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    93 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3  130 Zinc 4.5 mM 48 hrs, 4-day adult    89 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    154 cold shock, 4-day adult    151 heat shock, 4-day adult    34 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    93 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    130 Zinc 4.5 mM 48 hrs, 4-day adult    89 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    48 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH12078 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001090 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7088-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for bnb Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | heat sensitive bnbhs.PE Phenotype manifest in Allele embryonic epidermis bnbhs.PE presumptive embryonic/larval central nervous system bnbhs.PE
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of bnb Class Mutagen Stocks Known lesion bnbG1175 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bnb Class Mutagen Stocks Known lesion bnbGD6524 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes bnbhs.PE in vitro construct - regulatory fusion 0 Yes bnbtEa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel7464 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-bnb.E} NA UAS construct P{GD6524} NA characterization construct P{bnb+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Pk17EG1175 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
gliogenesis inferred from expression pattern (Egger et al., 2002) multicellular organismal development inferred from mutant phenotype (Eberl et al., 1992)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
bnb - CG17754 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bnb - CG4198 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) bnb - Cg25C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bnb - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bnb - RpS15Ab experimental knowledge based (Guruharsha et al., 2011) bnb - snRNP-U1-70K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bnb allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59181 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001090 DroID - A comprehensive database of gene and protein interactions. • FBgn0001090 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32872
Orthologs
OrthoDB Orthologs (79) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6282KZ Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG65J4QR
Orthologs in Drosophila Species (EOG6282KZ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\bnb     Drosophila melanogaster fruit fly  Dmel\Cht6     Drosophila simulans   Dsim\GD16968   Y Drosophila simulans   Dsim\GD22496   Y Drosophila sechellia   Dsec\GM10968   Y Drosophila sechellia   Dsec\GM14907   Y Drosophila sechellia   Dsec\GM25606   Y Drosophila sechellia   Dsec\GM11311   Y Drosophila sechellia   Dsec\GM16144   Y Drosophila sechellia   Dsec\GM22783 Y Y Drosophila sechellia   Dsec\GM23125   Y Drosophila sechellia   Dsec\GM17175   Y Drosophila sechellia   Dsec\GM16940   Y Drosophila sechellia   Dsec\GM13565   Y Drosophila sechellia   Dsec\GM11401   Y Drosophila sechellia   Dsec\GM21851   Y Drosophila sechellia   Dsec\GM10786   Y Drosophila yakuba   Dyak\GE17825   Y Drosophila yakuba   Dyak\GE17119   Y Drosophila ananassae   Dana\GF19856   Y Drosophila willistoni   Dwil\GK24942 Y Y Drosophila willistoni   Dwil\GK25829   Y Drosophila willistoni   Dwil\GK10816   Y Drosophila willistoni   Dwil\GK22460   Y Drosophila willistoni   Dwil\GK16213   Y Drosophila virilis   Dvir\GJ18726   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG65J4QR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cht-1 Y Caenorhabditis elegans Nematode  Cele\R09D1.10 Y Caenorhabditis elegans Nematode  Cele\C08H9.14 Y Caenorhabditis elegans Nematode  Cele\R09D1.6 Y Caenorhabditis elegans Nematode  Cele\T19H5.6 Y Caenorhabditis elegans Nematode  Cele\Y22D7AL.14 Y Caenorhabditis elegans Nematode  Cele\R09D1.8 Y Caenorhabditis elegans Nematode  Cele\T10D4.3 Y Caenorhabditis elegans Nematode  Cele\T01C4.1 Y Caenorhabditis elegans Nematode  Cele\T19H5.1 Y Caenorhabditis elegans Nematode  Cele\M01B2.6 Y Caenorhabditis elegans Nematode  Cele\C08H9.13 Y Caenorhabditis elegans Nematode  Cele\C45E5.3 Y Caenorhabditis elegans Nematode  Cele\R09D1.5 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020550gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005754gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009442gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020549gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018092gn Y Danio rerio Zebrafish  Drer\ENSDARG00000075745 Y Danio rerio Zebrafish  Drer\chia.6 Y Danio rerio Zebrafish  Drer\chia.4 Y Danio rerio Zebrafish  Drer\chia.3 Y Danio rerio Zebrafish  Drer\si:ch211-226m16.2 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000011839 Y Xenopus tropicalis Western clawed frog  Xtro\ctbs Y Xenopus tropicalis Western clawed frog  Xtro\chia Y Xenopus tropicalis Western clawed frog  Xtro\chit1 Y Gallus gallus Domestic chicken  Ggal\CTBS Y Gallus gallus Domestic chicken  Ggal\CHIA Y Gallus gallus Domestic chicken  Ggal\LOC768786 Y Gallus gallus Domestic chicken  Ggal\CHIA Y Mus musculus House mouse  Mmus\Chi3l1 Y Mus musculus House mouse  Mmus\Chi3l4 Y Mus musculus House mouse  Mmus\BC051070 Y Mus musculus House mouse  Mmus\ENSMUSG00000074340 Y Mus musculus House mouse  Mmus\Chit1 Y Mus musculus House mouse  Mmus\Ctbs Y Mus musculus House mouse  Mmus\Chi3l7 Y Rattus norvegicus Norway rat  Rnor\Chit1 Y Rattus norvegicus Norway rat  Rnor\Ctbs Y Rattus norvegicus Norway rat  Rnor\Chia Y Rattus norvegicus Norway rat  Rnor\Chi3l3 Y Rattus norvegicus Norway rat  Rnor\RGD1309110 Y Rattus norvegicus Norway rat  Rnor\Chi3l1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037116 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032282 Y Homo sapiens Human  Hsap\CHIA Y Homo sapiens Human  Hsap\CHI3L2 Y Homo sapiens Human  Hsap\OVGP1 Y Homo sapiens Human  Hsap\CTBS Y Homo sapiens Human  Hsap\CHI3L1 Y Homo sapiens Human  Hsap\CHIT1 Y
Human Orthologs (6)
Gene OMIM HGNC Hsap\CHIA     Hsap\CHI3L2     Hsap\OVGP1     Hsap\CTBS     Hsap\CHI3L1     Hsap\CHIT1
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\bnb Drosophila sechellia Dsec\GM22783 Drosophila erecta Dere\GG18091 Drosophila yakuba Dyak\GE15487 Drosophila ananassae Dana\GF19170 Drosophila pseudoobscura pseudoobscura Dpse\GA22338 Drosophila persimilis Dper\GL27007 Drosophila willistoni Dwil\GK24942 Drosophila grimshawi Dgri\GH12548
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	33540 w* P{EP}Pk17EG1175 bnbG1175
Genomic Clones ( 2 )
	BACR14D22 BACR25O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 239 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12078
Other clones	DPiM_GH12078
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06308 GH07854 GH07950 GH08249 GH08905 GH12527 GH13916 GH14934 GH15811 GH16034 GH17734 GH19063 GH20944 GH21272 GH21753 GH22762 GH24887 GH25071 HL02708 HL03103 HL04710 HL04922 LD07275 LD14950 LD16817 LD25401 LD30213 LD36880 LD37291 LP01615 LP10909 LP19176 LP19828 LP21992 LP22236 RE03840 RE03852 RE05037 RE05667 RE07325 RE11011 RE11078 RE12406 RE13545 RE17353 RE19538 RE19965 RE22545 RE28546 RE30081 RE33270 RE34260 RE36342 RE37658 RE41129 RE41372 RE43476 RE43477 RE46513 RE48607 RE49688 RE51407 RE52514 RE53269 RE57627 RE57855 RE60694 RE60737 RE60974 RE61775 RE62641 RE63425 RE63624 RE63664 RE66264 RE66448 RE66849 RE66865 RE67386 RE72591 RE72751 RE74086 RE74341 RH12740 RH18552 RH18587 RH23060 RH23879 RH25056 RH43443 RH46905 RH50162 RH52042 RH55025 RH58793 RH58888 RH58924 RH63460 RH69544 RH69728 RH73738 UT01293 UT01611
Other clones	11678 31453 35673 44587 47009 62129 62722 63186 63685 66492 78743 79240 79628 81750 81983 101606 103577 105385 105574 107528 146625 149489 181860 192931 214257.60 274456 569477 AA433285 CK01.8D.C7 CK01.30D.D1 CK01.51A.D4 CK01.59A.G9 CK01.62C.H8 CK01.66B.F6 CK01.72D.F12 CK01.77B.E9 CK01.82B.B4 CK01.84C.B2 CK01.104D.F1 CK01.111A.G8 CK01.141D.E11 CK01.142C.F11 CK00093 EC43522 EK000257 EK011412 EK031002 EK047920 EK050464 EK063146 EK064938 EK065607 EK067028 EK087721 EK115922 EK139102 EK141541 EK157003 EK160138 EK160201 EK170102 EK175206 EK187942 EK188762 EK190616 EK209324 EK213027 EK217333 EK226960 EK228541 EK230512 EK249245 EK255549 EK267102 EK274109 EK296320 EN14950 EP03649 FGM003A02 FGM208E07 FGM232D12 GH06465 GH09004 GH13683 GH27602 GH27746 HL01654 HL03468 HL04501 HL06502 HL06504 IP02213 IP13742 IP16989 IP17089 IP17189 LD30353 LD39312 LD42341 LD45548 LP15410 LP15976 LP22209 RE15022 RH15132 RH25948 RH26348 RH28428 RH40388 RH46976 RH50377 RP003144084 RP003178612 RP003216337 RP003267892 RP003372905 RP003374989 RP003467946 RP003506448 RP003521851 RP003597108 RP004055331 RP004056152 RP004220437 RP004225148 RP004246773 RP004401077 RP004464713 RP004487248 UT01480 UT01536 UT01576 UUGC0469 UUGC0694
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001090 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32872
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: bnb CG7088 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Pilot et al., 2006) A 6.7kb fragment including the bnb coding region, 2.6kb of upstream and 1.0kb downstream sequences, is sufficient to direct bnb epidermal ('bangles') and neural ('beads') expression. (Eberl et al., 1992) Prior to dorsal closure bnb expression is observed in the mesectoderm and presumptive epidermis in metameric pattern, expression becomes restricted after closure to segmentally reiterated sets of cells along the nervous system periphery. (Ng et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078682 NM_167633 NM_167634 NM_167635 RefSeq (Proteins) • NP_523406 NP_728201 NP_728202 NP_728203 DDBJ / EMBL / GenBank • AAF48888 AAL28230 AAN09476 AAN09477 AAN09478 AI134576 AW940448 AY060682 CAA45323 X63828 Entrez Gene - A searchable database of RefSeq genes. • 32872 UniProtKB/Swiss-Prot • P29746
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH12078
Linkouts
	BioGRID - A database of protein and genetic interactions • 59181 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001090 DroID - A comprehensive database of gene and protein interactions. • FBgn0001090 DRSC - Results from RNAi screens. • FBgn0001090 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001090 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7088-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001090 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32872 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32872 modMine - Data generated by the modENCODE project. • FBgn0001090
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	bnb (Jordan et al., 2005, Terry et al., 2006, Lott et al., 2011, Southall and Brand, 2009, Buffin and Gho, 2010, Nagoshi et al., 2010) Bnb (Anholt and Williams, 2010) CG7088 (Lebo et al., 2009) Gap43
Name Synonym	bangles and beads (Terry et al., 2006, Pilot et al., 2006, Lebo et al., 2009, Buffin and Gho, 2010) Bangles and beads (Robinson et al., 2010) Bangles-n-beads (Jordan et al., 2005)
Secondary FlyBase IDs
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 1 ) Website  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 2 )
	Fisher et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(52): 21330--21335 DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila. [FBrf0220344] Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...