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Gene Dmel\Gdh

General Information
Symbol	Dmel\Gdh	Species	D. melanogaster
Name	Glutamate dehydrogenase	Annotation symbol	CG5320
Feature type	protein_coding_gene	FlyBase ID	FBgn0001098
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	GLUD
Genomic Location
Chromosome (arm)	3R	Recombination map	3-81.7
Cytogenetic map	95C13-95D1	Sequence location	3R:19,761,680..19,768,824 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Glutamate dehydrogenase is referred to in FlyBase by the symbol Dmel\Gdh (CG5320, FBgn0001098). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glutamate dehydrogenase [NAD(P)+] activity; glutamate dehydrogenase (NAD+) activity; identical protein binding. There is experimental evidence that it is involved in the biological process: NADH oxidation; aerobic respiration; glutamate metabolic process. 15 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Glutamate dehydrogenase; Glutamate/phenylalanine/leucine/valine dehydrogenase; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult spermathecae, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1640835_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Gdh. Gene sequence location is 3R:19761680..19768824.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Gdh: Glutamate dehydrogenase Structural gene for NAD- dependent glutamate dehydrogenase [GDH (EC1.4.1.4)], which comprises six 57,000 dalton subunits. Enzyme activity inducible by addition of glutamate to medium. Nearly all larval activity can be isolated with the mitochondria.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Jumbo-Lucioni et al., 2010, BMC Genomics 11: 297 Sequence features HFA16679 BKN27890
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95C13-95D1   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95D1-95D4     (Louis, 1997.2.17) 95D1-95D4     (Louis, 1993.12.13) 95D1-95D4   (determined by in situ hybridisation)   (Ranz et al., 1999) 95D-95D   (determined by in situ hybridisation)   (Drosopoulou et al., 1997) 95D1-95D4   (determined by in situ hybridisation)   (Papadopoulou and Louis, 1990)
Experimentally Determined Recombination Data
Location	3-81.7
Left of (cM)	tx
Right of (cM)	hh
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gdh for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gdh-RA FBtr0089498  NM_079746   2192   562 Gdh-RB FBtr0089496  NM_170101   1830   404 Gdh-RF FBtr0089497  NM_206551   2157   549
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gdh-PA   FBpp0088988   62.5   562   8.43     NP_524470   AAF56209 Gdh-PB   FBpp0088496   44.5   404   7.10     NP_732922   AAN13962 Gdh-PF   FBpp0088990   61.1   549   8.58     NP_996274   AAS65200
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutamate/phenylalanine/leucine/valine dehydrogenase (IPR006095) Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (IPR006096) Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (IPR006097) Glutamate dehydrogenase (IPR014362) NAD(P)-binding domain (IPR016040) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05320
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201768   AA202076   AA246551   AA246783   AA263234   AA263497   AA263840   AA264699   AA391167   AA391834   AA392811   AA439936   AA440637   AA441440   AA540881   AA567430   AA698796   AA735289   AA803045   AA817402   AA820373   AA941103   AA941352   AA942515   AA942599   AA949072   AA949246   AA949913   AA949992   AA950116   AA950123   AA950162   AA950738   AA951304   AA952094   AA978925   AA979176   AA979181   AA979353   AA990663   AA990898   AE014297 AAF56209   AE014297 AAN13962   AE014297 AAS65200   AI062154   AI062485   AI062744   AI062748   AI062815   AI062821   AI063965   AI107463   AI107743   AI108533   AI108654   AI109122   AI110089   AI113601   AI134895   AI135847   AI135871   AI238652   AI257835   AI259484   AI259524   AI293099   AI294450   AI294800   AI296319   AI388049   AI388596   AI388651   AI388769   AI401931   AI402372   AI405047   AI455575   AI455647   AI456425   AI456627   AI456790   AI511812   AI512114   AI512348   AI512421   AI515039   AI515184   AI515712   AI516343   AI516514   AI516517   AI516987   AI517658   AI517872   AI518657   AI519373   AI519861   AI546410   AK283983   AQ025137   AQ254883   AW942692   AY061323 AAL28871   BG634580   BI161928   BI161929   BI162608   BI162609   BI164157   BI169329   BI171165   BI172378   BI172433   BI172616   BI173355   BI212535   BI212805   BI214085   BI227797   BI230296   BI230896   BI235011   BI236237   BI236934   BI240120   BI240578   BI243059   BI352555   BI356485   BI358171   BI361340   BI362064   BI362510   BI362563   BI364081   BI364108   BI364177   BI364545   BI364771   BI364811   BI365761   BI366233   BI366389   BI366455   BI366652   BI367275   BI367304   BI367516   BI368392   BI368852   BI368981   BI369084   BI370562   BI370706   BI373997   BI374093   BI374155   BI374306   BI374763   BI375033   BI482904   BI483473   BI483525   BI484312   BI484579   BI484916   BI485420   BI485431   BI485496   BI485959   BI486089   BI486387   BI567018   BI567153   BI567202   BI567250   BI569084   BI569085   BI569723   BI570102   BI570409   BI577577   BI578148   BI578755   BI579171   BI579346   BI579988   BI580269   BI580623   BI580670   BI580673   BI580945   BI580955   BI580956   BI582887   BI584450   BI585651   BI587120   BI589047   BI589731   BI589907   BI590041   BI590153   BI590192   BI590368   BI590390   BI604579   BI605483   BI605980   BI606870   BI608596   BI608676   BI609348   BI609571   BI610592   BI610616   BI612962   BI613057   BI614174   BI615798   BI620459   BI622828   BI622877   BI623311   BI624403   BI624995   BI625181   BI626285   BI627046   BI627856   BI627976   BI629950   BI631460   BI634728   BP548052   BP548341   BP549658   BP549659   BP551626   BP551627   BP554106   BP554107   BP559837   BP559838   BQ103414   BQ103491   BT001501 AAN71256   BT099832   BT128894   CA805802   CA807298   CK131242   CK132078   CK659902   CK660154   CK661531   CL705930   CO192328   CO196243   CO196269   CO267318   CO270504   CO271950   CO276094   CO276107   CO277336   CO286706   CO293234   CO301568   CO303688   CO320234   CO321632   CO327013   CO328323   CO342123   CZ470886   DQ311359   EC060276   EC060315   EC065673   EC078367   EC081788   EC088619   EC091039   EC091040   EC194685   EC202935   EC204650   EC211732   EC214686   EC218306   EC220341   EC224223   EC231437   EC232005   EC232165   EC233661   EC234467   EC239903   EC242855   EC252234   EL873497   EL878102   EL878103   EV575518   EV578694   EV584968   EV585570   EV590121   GH747695   GH747982   GH748491   GH748682   GH749854   GH749890   GH751431   GH752665   GH753135   GH753826   GH754552   GH755386   GH755756   GH756293   GH756367   GH756866   GH756955   GH759482   GH760029   GH760374   GH770337   GH770546   GH770820   GH774549   GH774779   GH775005   GH775071   GH776741   GH778838   GH779032   GH780706   GH781229   GH781802   GH781980   GH782579   GH783852   GH784139   GH784806   GH785067   GH786641   GH786941   GH787768   GH788133   GH788731   GH788935   GH789188   GH789471   GH790477   GH790586   GH791484   GH791968   GH792821   GH792990   GH794092   GH794796   GH794872   GH795059   GH796292   GH796420   GH796841   GH797075   GH797777   GH798493   GH798650   GH798681   GH798918   GH801034   GH804364   GH805075   GH805101   GH805320   GH806015   GH808533   GH808751   GH809129   GH809772   GH809858   GH810168   GH810280   GH813630   GH814463   GH814830   GH816275   GH816366   GH816517   GH817101   GH817870   GH817995   GH818184   GH818257   GH818408   GH819379   GH820323   GH820402   GH821737   GH822304   GH823042   GH823391   GH824543   GH824746   GH825437   GH825446   GH825926   GH826073   GH827956   GH828618   GH828995   GH829561   GH830292   GH830355   GH830483   GH831236   GH831332   GH831641   GH831644   GH831915   GH831920   GH832198   GH832208   GH832847   GH832891   GH833493   GH833793   GH834378   GH837810   GH837824   GH837911   GH838538   GH838645   GH839139   GH840149   GH840765   GH842009   GH842588   GH843669   GH844688   GH845794   GH846448   GH846877   GH847321   GH847532   GH848428   GH849708   GH850104   GH850228   GH850682   GH851290   GH851905   GH852034   GH852044   GH854061   GH854606   GH854793   GH855857   GH856338   GH857520   GH857676   GH859067   GH859245   GH859274   GH860148   GH860836   GH861550   GH863301   GH864083   GH864274   GH864607   GH865791   GH865837   GH866124   GH866485   GH866708   GH867025   GH867663   GH868549   GH868671   GH870021   GH870838   GH871044   GH871102   GH871120   GH871360   GH872223   GH872226   GH872240   GH873279   GH875306   GH876469   GH879569   GH879599   GH879708   GH879920   GH880615   GH881046   GH883726   GH883839   GH883850   GH884082   GH884173   GH885429   GH887173   GH887290   GH887846   GH888082   GH888156   GH888957   GH890315   GH891371   GH891781   GH892237   GH893693   GH894408   GH894921   GH895007   GH895658   GH896454   GH897160   GH897979   GH898196   GH898891   GH898994   GH900090   GH900331   GH900630   GH901010   GH901122   GH901146   GH901537   GH902899   GH903390   GH904265   GH904676   GH904988   GH905917   GH906151   GH906533   GH907092   GH907929   GH909386   GH909756   GH909848   GH911506   GH911878   GH912769   GH912793   GH913117   GH913190   GH913214   GH913790   GH914202   GH914641   GH914947   GH915996   GH916212   GH918720   GH919386   GH919625   GH920150   GH920375   GH922429   GH923527   GH923654   GH924318   GH926549   GH926694   GH926779   GH928899   GH930516   GH930660   GH932234   GH932432   GH932696   GH932848   GH933000   GH933788   GH936457   GH936674   GH938181   GH938628   GH939422   GH939467   GH939674   GH940018   GH940020   GH940291   GH940552   GH940740   Y11314 CAA72173   Z28976   Z28977   Z28978   Z28979   Z28980   Z29062 CAA82304   Z29063
UniProtKB/Swiss-Prot	P54385
UniProtKB/TrEMBL	Q8IMY1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   organism | ubiquitous   (Papadopoulou and Louis, 2000) embryonic stage 7   ventral furrow   (Papadopoulou and Louis, 2000) embryonic stage 8 -- 11   somatic mesoderm   (Papadopoulou and Louis, 2000) head mesoderm   (Papadopoulou and Louis, 2000) embryonic stage 12   ventral nerve cord   (Papadopoulou and Louis, 2000) hypopharyngeal lobe   (Papadopoulou and Louis, 2000) embryonic stage 12 -- 16   posterior midgut primordium   (Papadopoulou and Louis, 2000) embryonic hindgut   (Papadopoulou and Louis, 2000) anterior midgut primordium   (Papadopoulou and Louis, 2000) embryonic stage 13 -- 16   embryonic Malpighian tubule   (Papadopoulou and Louis, 2000) embryonic stage 14 -- 16   embryonic fat body   (Papadopoulou and Louis, 2000) embryonic stage 14 -- 17   presumptive embryonic/larval central nervous system   (Papadopoulou and Louis, 2000) embryonic stage 15 -- 17   embryonic somatic muscle   (Papadopoulou and Louis, 2000) third instar larval stage   wing disc   (Papadopoulou and Louis, 2000) ventral thoracic disc   (Papadopoulou and Louis, 2000) eye-antennal disc   (Papadopoulou and Louis, 2000) Comment:except the morphogenetic furrow wing pouch   (Papadopoulou and Louis, 2000) embryonic/larval optic lobe   (Papadopoulou and Louis, 2000) haltere disc   (Papadopoulou and Louis, 2000)
Additional Descriptive Data
	From stage 12, expression is stronger in the posterior regions of the midgut than the anterior part. (Papadopoulou and Louis, 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 5   organism | ubiquitous   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 6 -- 7   ventral furrow   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 8 -- 9   somatic mesoderm   • cytoplasm (Papadopoulou and Louis, 2000) head mesoderm   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 12   ventral nerve cord   • cytoplasm (Papadopoulou and Louis, 2000) hypopharyngeal lobe   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 12 -- 16   anterior midgut primordium   • cytoplasm (Papadopoulou and Louis, 2000) posterior midgut primordium   • cytoplasm (Papadopoulou and Louis, 2000) embryonic hindgut   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 13 -- 16   embryonic Malpighian tubule   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 13 -- 17   embryonic somatic muscle   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 14 -- 16   embryonic fat body   • cytoplasm (Papadopoulou and Louis, 2000) embryonic stage 14 -- 17   presumptive embryonic/larval central nervous system   • cytoplasm (Papadopoulou and Louis, 2000) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Muscles are strongly stained from stage 13 on. This is earlier than seen with in situ hybridization. High magnification shows that muscles are not stained evenly with the antibody. Stain accumulates at the ends and in the center of the muscles. (Papadopoulou and Louis, 2000)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001098    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001098 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001098 expression level Developmental Stage   Expression Level embryo 00-02hr    13383 embryo 02-04hr    14809 embryo 04-06hr    6726 embryo 06-08hr    3054 embryo 08-10hr    4475 embryo 10-12hr    8540 embryo 12-14hr    14547 embryo 14-16hr    38781 embryo 16-18hr    36076 embryo 18-20hr    32430 embryo 20-22hr    35097 embryo 22-24hr    32614 larva L1    69335 larva L2    57266 larva L3 12hr old    54410 larva L3 puffstage 1-2    18909 larva L3 puffstage 3-6    10450 larva L3 puffstage 7-9    6055 white prepupae new    5373 white prepupae 12hr    5675 white prepupae 24hr    6482 pupae 2d postWPP    8533 pupae 3d postWPP    32704 pupae 4d postWPP    15986 adult male 01day    15379 adult male 05day    13507 adult male 30day    10635 adult female 01day    17739 adult female 05day    12591 adult female 30day    12531 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13383) embryo 02-04hr  (14809) embryo 04-06hr  (6726) embryo 06-08hr  (3054) embryo 08-10hr  (4475) embryo 10-12hr  (8540) embryo 12-14hr  (14547) embryo 14-16hr  (38781) embryo 16-18hr  (36076) embryo 18-20hr  (32430) embryo 20-22hr  (35097) embryo 22-24hr  (32614) larva L1  (69335) larva L2  (57266) larva L3 12hr old  (54410) larva L3 puffstage 1-2  (18909) larva L3 puffstage 3-6  (10450) larva L3 puffstage 7-9  (6055) white prepupae new  (5373) white prepupae 12hr  (5675) white prepupae 24hr  (6482) pupae 2d postWPP  (8533) pupae 3d postWPP  (32704) pupae 4d postWPP  (15986) adult male 01day  (15379) adult male 05day  (13507) adult male 30day  (10635) adult female 01day  (17739) adult female 05day  (12591) adult female 30day  (12531) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13383) embryo 02-04hr  (14809) embryo 04-06hr  (6726) embryo 06-08hr  (3054) embryo 08-10hr  (4475) embryo 10-12hr  (8540) embryo 12-14hr  (14547) embryo 14-16hr  (38781) embryo 16-18hr  (36076) embryo 18-20hr  (32430) embryo 20-22hr  (35097) embryo 22-24hr  (32614) larva L1  (69335) larva L2  (57266) larva L3 12hr old  (54410) larva L3 puffstage 1-2  (18909) larva L3 puffstage 3-6  (10450) larva L3 puffstage 7-9  (6055) white prepupae new  (5373) white prepupae 12hr  (5675) white prepupae 24hr  (6482) pupae 2d postWPP  (8533) pupae 3d postWPP  (32704) pupae 4d postWPP  (15986) adult male 01day  (15379) adult male 05day  (13507) adult male 30day  (10635) adult female 01day  (17739) adult female 05day  (12591) adult female 30day  (12531) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (13383) embryo 02-04hr  (14809) embryo 04-06hr    6726 embryo 06-08hr    3054 embryo 08-10hr    4475 embryo 10-12hr    8540 embryo 12-14hr  (14547) embryo 14-16hr  (38781) embryo 16-18hr  (36076) embryo 18-20hr  (32430) embryo 20-22hr  (35097) embryo 22-24hr  (32614) larva L1  (69335) larva L2  (57266) larva L3 12hr old  (54410) larva L3 puffstage 1-2  (18909) larva L3 puffstage 3-6  10450 larva L3 puffstage 7-9    6055 white prepupae new    5373 white prepupae 12hr    5675 white prepupae 24hr    6482 pupae 2d postWPP    8533 pupae 3d postWPP  (32704) pupae 4d postWPP  (15986) adult male 01day  (15379) adult male 05day  (13507) adult male 30day  10635 adult female 01day  (17739) adult female 05day  (12591) adult female 30day  (12531) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13383 embryo 02-04hr    14809 embryo 04-06hr    6726 embryo 06-08hr    3054 embryo 08-10hr    4475 embryo 10-12hr    8540 embryo 12-14hr    14547 embryo 14-16hr    38781 embryo 16-18hr    36076 embryo 18-20hr    32430 embryo 20-22hr    35097 embryo 22-24hr    32614 larva L1    69335 larva L2    57266 larva L3 12hr old    54410 larva L3 puffstage 1-2    18909 larva L3 puffstage 3-6    10450 larva L3 puffstage 7-9    6055 white prepupae new    5373 white prepupae 12hr    5675 white prepupae 24hr    6482 pupae 2d postWPP    8533 pupae 3d postWPP    32704 pupae 4d postWPP    15986 adult male 01day    15379 adult male 05day    13507 adult male 30day    10635 adult female 01day    17739 adult female 05day    12591 adult female 30day    12531 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001098 expression level Developmental Stage   Expression Level embryo 00-02hr    13383 embryo 02-04hr    14809 embryo 04-06hr    6726 embryo 06-08hr    3054 embryo 08-10hr    4475 embryo 10-12hr    8540 embryo 12-14hr    14547 embryo 14-16hr    38781 embryo 16-18hr    36076 embryo 18-20hr    32430 embryo 20-22hr    35097 embryo 22-24hr    32614 larva L1    69335 larva L2    57266 larva L3 12hr old    54410 larva L3 puffstage 1-2    18909 larva L3 puffstage 3-6    10450 larva L3 puffstage 7-9    6055 white prepupae new    5373 white prepupae 12hr    5675 white prepupae 24hr    6482 pupae 2d postWPP    8533 pupae 3d postWPP    32704 pupae 4d postWPP    15986 adult male 01day    15379 adult male 05day    13507 adult male 30day    10635 adult female 01day    17739 adult female 05day    12591 adult female 30day    12531 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13383) embryo 02-04hr  (14809) embryo 04-06hr  (6726) embryo 06-08hr  (3054) embryo 08-10hr  (4475) embryo 10-12hr  (8540) embryo 12-14hr  (14547) embryo 14-16hr  (38781) embryo 16-18hr  (36076) embryo 18-20hr  (32430) embryo 20-22hr  (35097) embryo 22-24hr  (32614) larva L1  (69335) larva L2  (57266) larva L3 12hr old  (54410) larva L3 puffstage 1-2  (18909) larva L3 puffstage 3-6  (10450) larva L3 puffstage 7-9  (6055) white prepupae new  (5373) white prepupae 12hr  (5675) white prepupae 24hr  (6482) pupae 2d postWPP  (8533) pupae 3d postWPP  (32704) pupae 4d postWPP  (15986) adult male 01day  (15379) adult male 05day  (13507) adult male 30day  (10635) adult female 01day  (17739) adult female 05day  (12591) adult female 30day  (12531) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13383) embryo 02-04hr  (14809) embryo 04-06hr  (6726) embryo 06-08hr  (3054) embryo 08-10hr  (4475) embryo 10-12hr  (8540) embryo 12-14hr  (14547) embryo 14-16hr  (38781) embryo 16-18hr  (36076) embryo 18-20hr  (32430) embryo 20-22hr  (35097) embryo 22-24hr  (32614) larva L1  (69335) larva L2  (57266) larva L3 12hr old  (54410) larva L3 puffstage 1-2  (18909) larva L3 puffstage 3-6  (10450) larva L3 puffstage 7-9  (6055) white prepupae new  (5373) white prepupae 12hr  (5675) white prepupae 24hr  (6482) pupae 2d postWPP  (8533) pupae 3d postWPP  (32704) pupae 4d postWPP  (15986) adult male 01day  (15379) adult male 05day  (13507) adult male 30day  (10635) adult female 01day  (17739) adult female 05day  (12591) adult female 30day  (12531) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  13383 embryo 02-04hr  14809 embryo 04-06hr    6726 embryo 06-08hr    3054 embryo 08-10hr    4475 embryo 10-12hr    8540 embryo 12-14hr  14547 embryo 14-16hr  (38781) embryo 16-18hr  (36076) embryo 18-20hr  (32430) embryo 20-22hr  (35097) embryo 22-24hr  (32614) larva L1  (69335) larva L2  (57266) larva L3 12hr old  (54410) larva L3 puffstage 1-2  18909 larva L3 puffstage 3-6  10450 larva L3 puffstage 7-9    6055 white prepupae new    5373 white prepupae 12hr    5675 white prepupae 24hr    6482 pupae 2d postWPP    8533 pupae 3d postWPP  (32704) pupae 4d postWPP  15986 adult male 01day  15379 adult male 05day  13507 adult male 30day  10635 adult female 01day  17739 adult female 05day  12591 adult female 30day  12531 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13383 embryo 02-04hr    14809 embryo 04-06hr    6726 embryo 06-08hr    3054 embryo 08-10hr    4475 embryo 10-12hr    8540 embryo 12-14hr    14547 embryo 14-16hr    38781 embryo 16-18hr    36076 embryo 18-20hr    32430 embryo 20-22hr    35097 embryo 22-24hr    32614 larva L1    69335 larva L2    57266 larva L3 12hr old    54410 larva L3 puffstage 1-2    18909 larva L3 puffstage 3-6    10450 larva L3 puffstage 7-9    6055 white prepupae new    5373 white prepupae 12hr    5675 white prepupae 24hr    6482 pupae 2d postWPP    8533 pupae 3d postWPP    32704 pupae 4d postWPP    15986 adult male 01day    15379 adult male 05day    13507 adult male 30day    10635 adult female 01day    17739 adult female 05day    12591 adult female 30day    12531 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001098    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001098 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult spermathecae, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001098 expression level Tissue   Expression Level Larval Central Nervous System    1362.075 Larval Midgut    3652.9 Larval Hindgut    4089.6 Larval Malpighian Tubules    856.8 Larval Fat Body    1134.7 Larval Salivary Gland    1595.3 Larval Trachea    2118.65 Larval Carcass    3289.25 Adult Head    1906.5 Adult Eye    3655.95 Adult Brain    1457.3 Adult Thoracic-Abdominal Ganglion    1881.8 Adult Crop    2108.9 Adult Midgut    1711 Adult Hindgut    4508.5 Adult Malpighian Tubules    3675.3 Adult Fat Body    662.1 Adult Salivary Gland    572.4 Adult Heart    1314.875 Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary    974 Adult Testis    364.3 Adult Male Accessory Gland    700.1 Adult Carcass    1568.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1362.075) Larval Midgut  (3652.9) Larval Hindgut  (4089.6) Larval Malpighian Tubules  (856.8) Larval Fat Body  (1134.7) Larval Salivary Gland  (1595.3) Larval Trachea  (2118.65) Larval Carcass  (3289.25) Adult Head  (1906.5) Adult Eye  (3655.95) Adult Brain  (1457.3) Adult Thoracic-Abdominal Ganglion  (1881.8) Adult Crop  (2108.9) Adult Midgut  (1711) Adult Hindgut  (4508.5) Adult Malpighian Tubules  (3675.3) Adult Fat Body  (662.1) Adult Salivary Gland  (572.4) Adult Heart  (1314.875) Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary  (974) Adult Testis    364.3 Adult Male Accessory Gland  (700.1) Adult Carcass  (1568.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1362.075) Larval Midgut  (3652.9) Larval Hindgut  (4089.6) Larval Malpighian Tubules    856.8 Larval Fat Body  (1134.7) Larval Salivary Gland  (1595.3) Larval Trachea  (2118.65) Larval Carcass  (3289.25) Adult Head  (1906.5) Adult Eye  (3655.95) Adult Brain  (1457.3) Adult Thoracic-Abdominal Ganglion  (1881.8) Adult Crop  (2108.9) Adult Midgut  (1711) Adult Hindgut  (4508.5) Adult Malpighian Tubules  (3675.3) Adult Fat Body    662.1 Adult Salivary Gland    572.4 Adult Heart  (1314.875) Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary    974 Adult Testis    364.3 Adult Male Accessory Gland    700.1 Adult Carcass  (1568.9) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1362.075 Larval Midgut    3652.9 Larval Hindgut    4089.6 Larval Malpighian Tubules    856.8 Larval Fat Body    1134.7 Larval Salivary Gland    1595.3 Larval Trachea    2118.65 Larval Carcass    3289.25 Adult Head    1906.5 Adult Eye    3655.95 Adult Brain    1457.3 Adult Thoracic-Abdominal Ganglion    1881.8 Adult Crop    2108.9 Adult Midgut    1711 Adult Hindgut    4508.5 Adult Malpighian Tubules    3675.3 Adult Fat Body    662.1 Adult Salivary Gland    572.4 Adult Heart    1314.875 Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary    974 Adult Testis    364.3 Adult Male Accessory Gland    700.1 Adult Carcass    1568.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001098 expression level Tissue   Expression Level Larval Central Nervous System    1362.075 Larval Midgut    3652.9 Larval Hindgut    4089.6 Larval Malpighian Tubules    856.8 Larval Fat Body    1134.7 Larval Salivary Gland    1595.3 Larval Trachea    2118.65 Larval Carcass    3289.25 Adult Head    1906.5 Adult Eye    3655.95 Adult Brain    1457.3 Adult Thoracic-Abdominal Ganglion    1881.8 Adult Crop    2108.9 Adult Midgut    1711 Adult Hindgut    4508.5 Adult Malpighian Tubules    3675.3 Adult Fat Body    662.1 Adult Salivary Gland    572.4 Adult Heart    1314.875 Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary    974 Adult Testis    364.3 Adult Male Accessory Gland    700.1 Adult Carcass    1568.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1362.075) Larval Midgut  (3652.9) Larval Hindgut  (4089.6) Larval Malpighian Tubules  (856.8) Larval Fat Body  (1134.7) Larval Salivary Gland  (1595.3) Larval Trachea  (2118.65) Larval Carcass  (3289.25) Adult Head  (1906.5) Adult Eye  (3655.95) Adult Brain  (1457.3) Adult Thoracic-Abdominal Ganglion  (1881.8) Adult Crop  (2108.9) Adult Midgut  (1711) Adult Hindgut  (4508.5) Adult Malpighian Tubules  (3675.3) Adult Fat Body  662.1 Adult Salivary Gland  572.4 Adult Heart  (1314.875) Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary  (974) Adult Testis    364.3 Adult Male Accessory Gland  700.1 Adult Carcass  (1568.9) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1362.075 Larval Midgut  (3652.9) Larval Hindgut  (4089.6) Larval Malpighian Tubules    856.8 Larval Fat Body  1134.7 Larval Salivary Gland  1595.3 Larval Trachea  (2118.65) Larval Carcass  (3289.25) Adult Head  (1906.5) Adult Eye  (3655.95) Adult Brain  1457.3 Adult Thoracic-Abdominal Ganglion  (1881.8) Adult Crop  (2108.9) Adult Midgut  1711 Adult Hindgut  (4508.5) Adult Malpighian Tubules  (3675.3) Adult Fat Body    662.1 Adult Salivary Gland    572.4 Adult Heart  1314.875 Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary    974 Adult Testis    364.3 Adult Male Accessory Gland    700.1 Adult Carcass  1568.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1362.075 Larval Midgut    3652.9 Larval Hindgut    4089.6 Larval Malpighian Tubules    856.8 Larval Fat Body    1134.7 Larval Salivary Gland    1595.3 Larval Trachea    2118.65 Larval Carcass    3289.25 Adult Head    1906.5 Adult Eye    3655.95 Adult Brain    1457.3 Adult Thoracic-Abdominal Ganglion    1881.8 Adult Crop    2108.9 Adult Midgut    1711 Adult Hindgut    4508.5 Adult Malpighian Tubules    3675.3 Adult Fat Body    662.1 Adult Salivary Gland    572.4 Adult Heart    1314.875 Adult VirginFemale Spermatheca    441.6 Adult InseminatedFemale Spermatheca    478.5 Adult Ovary    974 Adult Testis    364.3 Adult Male Accessory Gland    700.1 Adult Carcass    1568.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1906.5   NA  Eye    3655.95   NA  Brain    1457.3   1362.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1881.8   NA  Crop    2108.9   3652.9  Midgut    1711   4089.6  Hindgut    4508.5   856.8  Malpighian Tubules    3675.3   1134.7  Fat Body    662.1   1595.3  Salivary Gland    572.4   NA  Heart    1314.875   2118.65  Trachea    NA   NA  VirginFemale Spermatheca    441.6   NA  InseminatedFemale Spermatheca    478.5   NA  Ovary    974   NA  Testis    364.3   NA  Male Accessory Gland    700.1   3289.25  Carcass    1568.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001098 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5320-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gdh Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable GdhEY07150 viable, with Scer\GAL4pnr-MD237 GdhGD11605 Sterility Allele fertile GdhEY07150 Other Phenotypes Allele electrophoretic variant GdhF GdhS Phenotype manifest in Allele
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Gdh Class Mutagen Stocks Known lesion Gdh5-HA-1122 1 -- Gdhc06642 piggyBac transposase 1 -- GdhEY07150 P-element activity 1 -- GdhNP0546 1 -- Gdh1156G natural population 0 -- Gdh5-HA-5059 0 -- Gdh986T natural population 0 -- GdhCPTI001709 piggyBac transposase 0 Yes GdhEP327 P-element activity 0 -- GdhEP656 P-element activity 0 -- GdhF 0 -- GdhS 0 -- GdhTG natural population 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gdh Class Mutagen Stocks Known lesion GdhGD11605 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GdhKK107890 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6196 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11605} NA P{KK107890} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP1171 NA P{EP}GdhEP327 NA P{EP}GdhEP656 NA P{EPgy2}GdhEY07150 NA P{GSV1}C919C919 NA P{XP}Gdhd08449 NA miscellaneous insertions P{GT1}BG02181BG02181 NA P{RS5}Gdh5-HA-1122 NA P{RS5}Gdh5-HA-5059 NA PBac{681.P.FSVS-1}GdhCPTI001709 NA PBac{PB}Gdhc06642 NA insertion of enhancer trap binary system P{GawB}GdhNP0546 No insertion of enhancer trap P{luc-sniffer}3-89 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
glutamate dehydrogenase (NAD+) activity inferred from direct assay (Bond and Sang, 1968) glutamate dehydrogenase [NAD(P)+] activity inferred from direct assay (Prezioso et al., 1985, Caggese et al., 1982, Nowak and Piechowska, 1986, Bond and Sang, 1968) identical protein binding inferred from direct assay (Caggese et al., 1982)
Biological Process
CV term Evidence References
aerobic respiration inferred from direct assay (Nowak and Piechowska, 1986) glutamate metabolic process inferred from direct assay (Caggese et al., 1982, Bond and Sang, 1968) NADH oxidation inferred from direct assay (Caggese et al., 1982)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from direct assay (Nowak and Piechowska, 1986) mitochondrion inferred from direct assay (Bond and Sang, 1968)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
glutamate dehydrogenase [NAD(P)+] activity inferred from sequence or structural similarity with mouse Glud (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P00367 AND inferred from sequence or structural similarity with UniProt:P49448 (Sardiello et al., 2003.6.11) nucleotide binding inferred from electronic annotation with InterPro:IPR016040 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
glutamate catabolic process to 2-oxoglutarate inferred from sequence or structural similarity with UniProtKB:P00367 AND inferred from sequence or structural similarity with UniProt:P49448 (Sardiello et al., 2003.6.11) NOT sperm storage traceable author statement (Chapman, 2001)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from sequence or structural similarity (Swiss-Prot Project Members, 2001.8.20) inferred from sequence or structural similarity with UniProtKB:P00367 AND inferred from sequence or structural similarity with UniProt:P49448 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gdh allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67768 DroID - A comprehensive database of gene and protein interactions. • FBgn0001098 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42832
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17976 Dere\GG12388 Dgri\GH19680 Dmoj\GI22276 Dper\GL24163 Dpse\GA18802 Dsec\GM23525 Dsim\GD18335 Dvir\GJ24069 Dwil\GK11603 Dyak\GE10843
Curated drosophilid orthologs	Daur\Gdh   Dbio\Gdh   Dbuz\Gdh (Ranz et al., 1999) Dgri\Gdh (Sztal et al., 2007) Djam\Gdh   Dkik\Gdh   Dmoj\Gdh (Sztal et al., 2007) Dpse\GA18802   Drep\Gdh (Ranz et al., 1999) Dsec\Gdh   Dseg\Gdh   Dser\Gdh   Dsim\Gdh   Dvir\Gdh (Ranz et al., 1999)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010464-PB Aedes aegypti (mosquito) AGAP004362-PA Anopheles gambiae (mosquito) XP_392776.2 Apis mellifera (honey bee) XP_001951708.1 Acyrthosiphon pisum (pea aphid) 34107 Batrachochytrium dendrobatidis (chytrid fungus) 130686 Branchiostoma floridae (lancelet) XP_001893113.1 Brugia malayi (roundworm nematode) BGIBMGA006507-PA Bombyx mori (silk worm) ENSBTAP00000009923 Bos taurus (bovine) CAL0004374 Candida albicans (a form of yeast) CBP01582 Caenorhabditis briggsae (nematode) CE06652 Caenorhabditis elegans (worm) ENSCAFP00000023709 Canis familiaris (dog) ENSCINP00000014974 Ciona intestinalis (sea squirt) JA06996 Caenorhabditis japonica (nematode) CML049C Cyanidioschyzon merolae (red alga) CPIJ014605 Culex pipens (mosquito) ENSCPOP00000004647 Cavia porcellus (guinea pig) 82916 Chlamidomonas reinhardtii (green alga) RP21258 Caenorhabditis remanei (nematode) ENSCSAVP00000014453 Ciona savignyi (sedentary tunicate) 158397 Capitella spl (polychaete worm) DDB0231438 Dictyostelium discoideum (amoeba) DEHA2C17204g Debaryomyces Hansenii (yeast) 187316 Daphnia pulex (daphnia) ENSDARP00000008646 Danio rerio (zebra fish) ENSECAP00000006100 Equus caballus (horse) ENSGACP00000003729 Gymnopilus aculeatus (mushroom) ENSGALP00000003139 Gallus gallus (chicken) GL50803_21942 Giardia lamblia (flagellated protozoan) 186449 Hypsipyla robusta (cedar shoot borer) ENSP00000277865 Homo sapiens (human) ISCW000393-PA Ixodes scapularis (deer tick) KLLA0F00594g Kluyveromyces lactis (yeast) 177468 Lottia gigantea (owl limpet) LmjF28.2910 Leishmania major (virus) 33746 Monocosta brevicollis (choanoflagellate) ENSMODP00000034856 Monodelphis domestica (gray opossum) ENSMMUP00000029068 Macaca mulatta (rhesus monkey) ENSMUSP00000022322 Mus musculus (house mouse) 243194 Nematostella vectensis (starlet anemone) XP_001607265.1 Nasonia vitripennis (wasp) ENSORLP00000013067 Oryzias latipes (japanese killifish) PF14_0286 Plasmodium falciparum (protozoal parasite) PHUM005743-PA Pediculus humanus (human body louse) PP18922 Pristionchus pacificus (nematode) 190253 Physcomitrella patens (moss) ENSPPYP00000003292 Pongo pygmaeus (orangutan) 71959 Phytophthora ramorum (sudden oak death pathogen) 108919 Phytophthora sojae (root rot pathogen) 571209 Populus trichocarpa (black cottonwood) 575509 Populus trichocarpa (black cottonwood) 826140 Populus trichocarpa (black cottonwood) 828764 Populus trichocarpa (black cottonwood) ENSPTRP00000004734 Pan troglodytes (chimpanzee) ENSRNOP00000013789 Rattus norvegicus (norway rat) Smp_093820 Schistosoma mansoni (trematode parasite) XP_001192018.1 Strongylocentrotus purpuratus (purple sea urchin) 36699 Trichoplax adhaerens (metazoa) XP_968936.1 Tribolium castaneum (red flour beetle) Tc00.1047053507875.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508111.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008014 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009100 Takifugu rubripes (pufferfish Takifugu) 3758.m00216 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000017882 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14079 LH16933 ISCW000393 FBgn0228680 FBgn0213614 FBgn0211154 FBgn0189864 FBgn0178391 JGI_V11_187316 FBgn0078802 FBgn0161753 FBgn0145004 FBgn0127144 FBgn0104676 FBgn0094994 CPIJ014605 BGIBMGA006507 ACYPI010216 GB15079 AGAP004362 AAEL010464 PB23534 PHUM106580 GLEAN_04929 GLEAN_02057
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	20165 y1 w67c23; P{EPgy2}GdhEY07150
Harvard	- PBac{PB}Gdhc06642
Kyoto	125088 w1118; P{RS5}Gdh5-HA-1122 103646 w*; P{GawB}GdhNP0546 / TM3, Ser1
VDRC	v22059 w1118; P{GD11605}v22059
Genomic Clones ( 2 )
	BACR05C11 BACR15J11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 572 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23954 LD34409
Other clones	MIP08329 RE31353
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT30830 GH02059 GH02065 GH02159 GH02165 GH04091 GH05158 GH05578 GH07715 GH07864 GH09548 GH09968 GH12471 GH13746 GH14737 GH16190 GH19553 GH19616 GH19771 GH21576 GH24947 GH24955 GH27607 GH28705 GM06874 GM19778 HL05710 LD04974 LD05491 LD05725 LD06510 LD07046 LD09243 LD14647 LD15482 LD20727 LD28476 LD28649 LD31704 LD33867 LD35177 LD36444 LD36710 LD36921 LD38287 LD38940 LD39685 LD41361 LD42179 LD42407 LD42410 LD43340 LD43839 LD44195 LD44293 LD46710 LD46901 LD47974 LP02907 LP02956 LP07827 LP08260 LP10179 LP13321 LP18031 LP18460 LP21112 RE03760 RE44860 RE49125 RE51730 RE53043 RE53294 RE57429 RE61677 RE61862 RE62436 RE66436 RE67705 RE68831 RE69323 RE71278 RE72669 RE74104 RE74433 RE74839 RH02354 RH03209 RH03429 RH03735 RH03976 RH04010 RH14370 RH36845 RH37016 RH42126 RH54751 RH54912 RH58893 RH65419 RH68238 RH69320 RH69995 RH71103 RH72019
Other clones	281 5338 7777 37892 54916 60222 73271 118091 121456 122265 145349 173377 177511 214381.22 282414 CK01.12D.C8 CK01.60C.G5 CK01.96B.G10 CK01.109D.A6 CK01.113A.F10 CK01.145C.C11 CK01.145C.F8 Dmel_dig_000491_0691_3726 Dmel_dig_007806_0709_2843 Dmel_dig_008446_0594_3673 Dmel_dig_016084_0699_2725 Dmel_neb_010335_0344_0525 EC33536 EK002341 EK002541 EK063627 EK099135 EK105256 EK119656 EK119710 EK123859 EK149428 EK181427 EK186051 EK202216 EK242511 EK282958 EP05507 EP09005 EP13864 ESG017b.E21_E02 ESG0119d.B21_C08 FGH123E04 FGH126F12 FGM102G04 FGM213H08 FGM228A07 FGM323C01 GH01254 GH01707 GH03849 GH13773 GH18785 HL01176 IP05348 IP08008 LD03817 LD04008 LD06543 LD08527 LD10729 LD12117 LD16377 LD22669 LD25065 LD25454 LD26773 LD26914 LD27827 LD28069 LD28581 LD28658 LD29145 LD29834 LD30102 LD30845 LD33130 LD33465 LD33474 LD34473 LD43002 LP06322 RE01387 RE01882 RE08976 RE10469 RE12862 RE14840 RE14922 RE15149 RE16158 RE16256 RE17640 RE18044 RE19791 RE25048 RE30805 RE32269 RE33065 RE36769 RE37451 RE40604 RE42652 RE45515 RE46527 RE47085 RE47159 RE49155 RE49240 RE49696 RE49949 RE49995 RE51140 RE51916 RE51996 RE52235 RE53011 RE54357 RE54904 RE55051 RE55167 RE57235 RE61487 RE61611 RE62745 RE65713 RE66375 RE67394 RE68106 RE68739 RE68751 RE69462 RE69805 RE71960 RE73159 RE73365 RE74888 RE74891 RE75195 RH01006 RH01283 RH01861 RH02731 RH03592 RH03778 RH13159 RH13301 RH14120 RH16105 RH16143 RH21310 RH23658 RH25273 RH27389 RH30720 RH37068 RH37145 RH38946 RH41987 RH43486 RH45581 RH51613 RH55438 RH61037 RH63955 RH64783 RH66856 RH69487 RH73713 RP003001024 RP003002055 RP003002478 RP003003595 RP003006131 RP003008350 RP003008787 RP003008869 RP003009878 RP003010504 RP003015536 RP003015678 RP003017958 RP003018173 RP003022949 RP003026504 RP003026679 RP003028649 RP003035393 RP003035534 RP003037422 RP003038208 RP003041165 RP003041516 RP003047186 RP003051980 RP003057016 RP003061657 RP003065879 RP003066978 RP003067650 RP003067857 RP003068711 RP003072892 RP003074466 RP003078566 RP003079921 RP003081906 RP003083655 RP003086072 RP003086902 RP003090306 RP003091662 RP003092218 RP003096173 RP003097835 RP003107419 RP003112698 RP003114966 RP003116548 RP003118381 RP003120957 RP003132068 RP003134905 RP003136550 RP003137665 RP003141022 RP003146936 RP003148972 RP003149017 RP003149196 RP003150960 RP003155828 RP003156136 RP003156450 RP003157947 RP003158623 RP003160710 RP003162620 RP003173879 RP003174862 RP003175717 RP003178243 RP003178378 RP003185302 RP003185874 RP003187119 RP003187891 RP003188563 RP003190107 RP003192339 RP003192623 RP003197365 RP003201510 RP003201598 RP003201613 RP003201685 RP003202221 RP003202880 RP003203897 RP003206014 RP003206617 RP003207888 RP003210006 RP003214219 RP003215154 RP003215317 RP003217501 RP003219395 RP003219539 RP003220951 RP003224086 RP003226243 RP003226272 RP003227930 RP003232133 RP003233686 RP003241242 RP003242697 RP003245502 RP003246396 RP003248206 RP003248808 RP003249501 RP003251335 RP003252165 RP003259815 RP003262873 RP003263133 RP003263805 RP003266594 RP003267383 RP003268560 RP003272394 RP003275802 RP003277633 RP003278014 RP003283149 RP003283494 RP003284164 RP003288361 RP003290085 RP003293018 RP003293471 RP003295216 RP003296850 RP003298331 RP003299494 RP003299816 RP003299881 RP003301587 RP003301831 RP003301891 RP003302910 RP003303302 RP003303345 RP003304341 RP003310715 RP003315415 RP003320672 RP003324079 RP003330028 RP003333339 RP003335140 RP003335751 RP003337900 RP003340760 RP003342197 RP003342214 RP003345200 RP003345610 RP003346677 RP003347002 RP003349398 RP003352931 RP003353037 RP003361297 RP003364275 RP003377358 RP003381558 RP003382281 RP003382626 RP003391211 RP003392036 RP003392263 RP003392346 RP003393474 RP003393958 RP003394970 RP003395262 RP003395464 RP003396255 RP003397072 RP003400373 RP003404158 RP003417448 RP003419369 RP003424660 RP003429576 RP003430492 RP003430687 RP003432234 RP003435894 RP003443901 RP003445623 RP003454035 RP003454558 RP003460459 RP003461391 RP003466322 RP003467220 RP003470045 RP003472795 RP003473001 RP003475421 RP003480538 RP003480569 RP003481613 RP003481885 RP003483187 RP003485437 RP003485483 RP003485604 RP003486098 RP003490807 RP003491316 RP003495929 RP003496666 RP003497699 RP003500059 RP003503748 RP003509707 RP003512628 RP003515010 RP003516261 RP003517062 RP003517735 RP003518128 RP003520600 RP003526179 RP003528570 RP003532920 RP003534122 RP003537571 RP003539782 RP003544402 RP003544930 RP003545840 RP003549178 RP003552244 RP003556902 RP003558039 RP003558282 RP003562620 RP003570753 RP003576287 RP003576683 RP003579907 RP003580163 RP003585774 RP003587753 RP003587907 RP003588870 RP003590339 RP003591047 RP003598839 RP003599179 RP003601903 RP003607704 RP003607949 RP003608931 RP003612075 RP003615264 RP003616516 RP003622248 RP003626128 RP003628459 RP003629365 RP003632417 RP003635693 RP003642428 RP003642464 RP003644940 RP003647356 RP003648340 RP003649021 RP003649089 RP003654630 RP003662021 RP003662574 RP003668728 RP003674594 RP003675826 RP003675947 RP003677044 RP003680925 RP003682040 UUGC0819 UUGC0897
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001098 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42832
Antibody Information
	polyclonal (Papadopoulou and Louis, 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gdh CG5320 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Gdh has been isolated and characterised. (Papadopoulou and Louis, 1990) The distribution of Gdh enzyme in the larva and adult has been studied. (Chase and Kankel, 1987) Gdh enzyme has been isolated from the larvae of two D.melanogaster strains and characterised biochemically. (Prezioso et al., 1985) Structural gene for NAD+-dependent glutamate dehydrogenase (GDH), which comprises six 57,000 dalton subunits. Enzyme activity inducible by addition of glutamate to medium. Nearly all larval activity can be isolated with the mitochondria.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079746 NM_170101 NM_206551 RefSeq (Proteins) • NP_524470 NP_732922 NP_996274 DDBJ / EMBL / GenBank • AA820373 AA990898 AAF56209 AAL28871 AAN13962 AAN71256 AAS65200 AQ025137 AQ254883 AW942692 AY061323 BT001501 CAA72173 CAA82304 CL705930 CZ470886 Y11314 Z28976 Z28977 Z28978 Z28979 Z28980 Z29062 Z29063 Entrez Gene - A searchable database of RefSeq genes. • 42832 UniProtKB/Swiss-Prot • P54385 UniProtKB/TrEMBL • Q8IMY1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glutamate/phenylalanine/leucine/valine dehydrogenase (IPR006095) Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (IPR006096) Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (IPR006097) Glutamate dehydrogenase (IPR014362) NAD(P)-binding domain (IPR016040) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05320
Linkouts
	BioGRID - A database of protein and genetic interactions • 67768 DroID - A comprehensive database of gene and protein interactions. • FBgn0001098 DRSC - Results from RNAi screens. • FBgn0001098 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001098 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5320-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001098 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42832 InParanoid A subset of ortholog calls from InParanoid. • AAEL010464-PB Aedes aegypti (mosquito) AGAP004362-PA Anopheles gambiae (mosquito) XP_392776.2 Apis mellifera (honey bee) XP_001951708.1 Acyrthosiphon pisum (pea aphid) 34107 Batrachochytrium dendrobatidis (chytrid fungus) 130686 Branchiostoma floridae (lancelet) XP_001893113.1 Brugia malayi (roundworm nematode) BGIBMGA006507-PA Bombyx mori (silk worm) ENSBTAP00000009923 Bos taurus (bovine) CAL0004374 Candida albicans (a form of yeast) CBP01582 Caenorhabditis briggsae (nematode) CE06652 Caenorhabditis elegans (worm) ENSCAFP00000023709 Canis familiaris (dog) ENSCINP00000014974 Ciona intestinalis (sea squirt) JA06996 Caenorhabditis japonica (nematode) CML049C Cyanidioschyzon merolae (red alga) CPIJ014605 Culex pipens (mosquito) ENSCPOP00000004647 Cavia porcellus (guinea pig) 82916 Chlamidomonas reinhardtii (green alga) RP21258 Caenorhabditis remanei (nematode) ENSCSAVP00000014453 Ciona savignyi (sedentary tunicate) 158397 Capitella spl (polychaete worm) DDB0231438 Dictyostelium discoideum (amoeba) DEHA2C17204g Debaryomyces Hansenii (yeast) 187316 Daphnia pulex (daphnia) ENSDARP00000008646 Danio rerio (zebra fish) ENSECAP00000006100 Equus caballus (horse) ENSGACP00000003729 Gymnopilus aculeatus (mushroom) ENSGALP00000003139 Gallus gallus (chicken) GL50803_21942 Giardia lamblia (flagellated protozoan) 186449 Hypsipyla robusta (cedar shoot borer) ENSP00000277865 Homo sapiens (human) ISCW000393-PA Ixodes scapularis (deer tick) KLLA0F00594g Kluyveromyces lactis (yeast) 177468 Lottia gigantea (owl limpet) LmjF28.2910 Leishmania major (virus) 33746 Monocosta brevicollis (choanoflagellate) ENSMODP00000034856 Monodelphis domestica (gray opossum) ENSMMUP00000029068 Macaca mulatta (rhesus monkey) ENSMUSP00000022322 Mus musculus (house mouse) 243194 Nematostella vectensis (starlet anemone) XP_001607265.1 Nasonia vitripennis (wasp) ENSORLP00000013067 Oryzias latipes (japanese killifish) PF14_0286 Plasmodium falciparum (protozoal parasite) PHUM005743-PA Pediculus humanus (human body louse) PP18922 Pristionchus pacificus (nematode) 190253 Physcomitrella patens (moss) ENSPPYP00000003292 Pongo pygmaeus (orangutan) 71959 Phytophthora ramorum (sudden oak death pathogen) 108919 Phytophthora sojae (root rot pathogen) 571209 Populus trichocarpa (black cottonwood) 575509 Populus trichocarpa (black cottonwood) 826140 Populus trichocarpa (black cottonwood) 828764 Populus trichocarpa (black cottonwood) ENSPTRP00000004734 Pan troglodytes (chimpanzee) ENSRNOP00000013789 Rattus norvegicus (norway rat) Smp_093820 Schistosoma mansoni (trematode parasite) XP_001192018.1 Strongylocentrotus purpuratus (purple sea urchin) 36699 Trichoplax adhaerens (metazoa) XP_968936.1 Tribolium castaneum (red flour beetle) Tc00.1047053507875.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508111.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008014 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009100 Takifugu rubripes (pufferfish Takifugu) 3758.m00216 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000017882 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42832 modMine - Data generated by the modENCODE project. • FBgn0001098 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14079 LH16933 ISCW000393 FBgn0228680 FBgn0213614 FBgn0211154 FBgn0189864 FBgn0178391 JGI_V11_187316 FBgn0078802 FBgn0161753 FBgn0145004 FBgn0127144 FBgn0104676 FBgn0094994 CPIJ014605 BGIBMGA006507 ACYPI010216 GB15079 AGAP004362 AAEL010464 PB23534 PHUM106580 GLEAN_04929 GLEAN_02057
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG5320 (Stempfl et al., 2002, Whitfield, 2000.9.6, Molnar et al., 2006, Mohammad et al., 2009, Baltzer et al., 2009, Tiefenböck et al., 2010, Keleman et al., 2009.8.5, Cammarato et al., 2011) DHE3 (Mushegian et al., 1998) Gdh (Turner et al., 2008, Papadopoulou and Louis, 2000, Molnar et al., 2006, Mohammad et al., 2009, Laayouni et al., 2007, Wasbrough et al., 2010, Jumbo-Lucioni et al., 2010) GDH (Chapman, 2001, Chase and Kankel, 1987, Caggese et al., 1982, Nowak and Piechowska, 1986, Baltzer et al., 2009, Tiefenböck et al., 2010) gdh (Louis, 1997.2.17) GLUD (Louis, 1993.12.13, Louis, 1993.12.13, Louis, 1993.12.13, Louis, 1993.12.13, Louis, 1993.12.13, Louis, 1993.12.13) GLU-D (Choudhary et al., 1992) Glud (Papadopoulou and Louis, 1990, ) GLUD pre-mRNA (Louis, 1993.12.13)
Name Synonym	Glutamate dehydrogenase (Sambandan et al., 2006, Caggese et al., 1982, Baltzer et al., 2009, Tiefenböck et al., 2010, Robinson et al., 2010, Cammarato et al., 2011) glutamate dehydrogenase (Nowak and Piechowska, 1986, Bond and Sang, 1968) NAD-dependent glutamate dehydrogenase (Laayouni et al., 2007)
Secondary FlyBase IDs
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 8 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Jumbo-Lucioni et al., 2010, BMC Genomics 11: 297 Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. [FBrf0210956] Robinson et al., 2010, Mech. Ageing Dev. 131(9): 584--590 Insights into aging through measurements of the Drosophila proteome as a function of temperature. [FBrf0211959] Tiefenböck et al., 2010, EMBO J. 29(1): 171--183 The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. [FBrf0209639] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...