transmembrane - novel serine esterase homolog - functions in glia to ensure a secure blood-brain barrier - located to tricellular junctions and is critical for the formation of tricellular and septate junctions and permeability barrier function
Gene model reviewed during 5.45
Gene model reviewed during 5.48
1023 (aa); 155 (kD observed)
Extensively O-glycosylated and also N-glycosylated.
About four tyrosines are sulfated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Glt using the Feature Mapper tool.
In situ hybridization shows that Glt is enriched in border follicle cells relative to follicle cells in stage S9 or S10 egg chambers.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Glt in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In vitro fusion of the homologous extracellular domain of Egfr and Glt to the Nrt cytoplasmic domain can mediate aggregation of cells incubated with a soluble crude fraction containg Nrt ligand activity. The binding site for the Nrt ligand is localised within the extracellular domain. A stretch of 25 amino acids forms an alpha-helix located close to the pseudocatalytic site and is crucial for the adhesive function.
Encodes an acidic sulfated glycoprotein of basement membranes.